Engineering
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Quantum Dot Film Can Withstand High Temperatures and Humidity
The joint KAIST research team of Professor Byeong-Soo Bae of the Department of Materials Science and Engineering and Professor Doh Chang Lee of the Department of Chemical and Biomolecular Engineering was able to fabricate a siloxane-encapsulated quantum dot film, which exhibits stable emission intensity over one month even at high temperatures and humidity.
The results of this study were published in the Journal of the American Chemical Society (JACS) on November 29, 2016. The research article is entitled “Quantum Dot/Siloxane Composite Film Exceptionally Stable against Oxidation under Heat and Moisture.” (DOI: 10.1021/jacs.6b10681)
Quantum dots (QDs), light-emitting diodes (LEDs) for next-generation displays, are tiny particles or nanocrystals of semiconducting materials. Their emission wavelength can easily be adjusted by changing their sizes, which are just a few nanometers. A wide spectrum of their colors can also achieve ultra-high definition displays.
Due to these characteristics, QDs are coated on a film as a polymer resin in dispersed form, or they are spread on an LED light source. They are thus considered to be crucial for next generation displays.
Despite their exceptional optical properties, however, QDs are easily oxidized in a high temperature and high humidity environment, and, as a result, this greatly deteriorates their luminescence quality (quantum efficiency). Therefore, they are encapsulated in an extra thin layer to block oxygen and moisture.
QD displays in the current market have a film inserted to separate them from LEDs, which create heat. The high unit cost of this protective layer, however, increases the overall cost of displays, lowering their price competitiveness in the market.
For a solution, the research team applied the sol-gel condensation reaction of silane precursors with QDs. This technology uses the reactions of chemical substances to synthesize ceramics or glass at a low temperature.
The team applied QDs in a heat resistant siloxane polymer by employing this technology. The siloxane resin acted as a cup holding the QDs and also blocked heat and moisture. Thus, their performance can be maintained without an extra protective film.
QDs are evenly dispersed into the resin from a chemical process to fabricate a QD embedded film and retained the high quality luminescence not only at a high temperature of 85°C and in a high humidity of 85%, but also in a high acid and high base environment. Remarkably though, the luminescence actually increased in the high humidity environment.
If this technology is used, the overall price of displays will decrease by producing a stable QD film without an extra protective barrier. In the future, the QD film can be directly applied to a blue LED light source. As a result, it will be possible to develop a QD display that can reduce the amount of QDs needed and improve its performance.
Professor Bae said, “We have proposed a way to make quantum dots overcome their limitations and have wide applications as they are being developed for next-generation displays. Our technology will make significant contributions to the display industry in the country.”
He also added, “In the future, we plan to cooperate with companies both in and out of the country to improve the performance of quantum dots and concentrate on their commercialization.”
The research team is currently applying for related patents both in and out of the country. The team is also plan ning to transfer the patents to Sol Ip Technology Inc., a company founded at KAIST, to start the commercialization.
Picture 1:
Siloxane-encapsulated quantum dot (QD) films showing performance stability in boiling water
Picture 2 and 3:
So-gel condensation reaction in silane precursors between Methacryloxypropyltrimethoxysilane (MPTS) and diphenylsilanediol (DPSD). The inset shows photographs of a QD-oligosiloxane resin under room light (left) and a UV lamp (λ = 365 nm) (right).
Free radical addition reactions among carbon double bonds of methacryl functional groups and oleic acids. The inset shows photographs of a QD-silox film under room light (left) and a UV lamp (λ = 365 nm) (right).
2017.02.24 View 9475 -
Prof. Woo Chang Kim Is Appointed as Managing Editor of Quantitative Finance
Professor Woo Chang Kim of the Industrial and Systems Engineering Department has been elected as the Managing Editor of Quantitative Finance.
Founded in 2001, Quantitative Finance has been an internationally-acclaimed peer-reviewed journal in the field of financial engineering, along with Mathematical Finance.
This is the first time for a Korean researcher to be named for the editorial board, which consists of eminent scholars from around the world, including four Nobel laureates.
Professor Kim’s expertise lies in financial optimization, portfolio management, and asset liability management. In recent years, he has focused his research on robo-advisors in the area of FinTech, and for this contribution, he was appointed as managing editor.
Professor Kim also served as an editor, deputy editor, and a member of the editorial boards for various journals, including the Journal of Portfolio Management and Optimization and Engineering. Currently, he serves as a member of the Korean National Pension Fund’s Electoral Commission, an adviser to Samsung Asset Management Co., Ltd., and the director of the KAIST Asset Management for Future Technology Research Center that was opened in October 2016.
2017.02.23 View 7403 -
Controlling Turtle Motion with Human Thought
KAIST researchers have developed a technology that can remotely control an animal’s movement with human thought.
In the 2009 blockbuster “Avatar,” a human remotely controls the body of an alien. It does so by injecting human intelligence into a remotely located, biological body. Although still in the realm of science fiction, researchers are nevertheless developing so-called ‘brain-computer interfaces’ (BCIs) following recent advances in electronics and computing. These technologies can ‘read’ and use human thought to control machines, for example, humanoid robots.
New research has demonstrated the possibility of combining a BCI with a device that transmits information from a computer to a brain, or known as a ‘computer-to-brain interface’ (CBI). The combination of these devices could be used to establish a functional link between the brains of different species. Now, researchers from the Korea Advanced Institute of Science and Technology (KAIST) have developed a human-turtle interaction system in which a signal originating from a human brain can affect where a turtle moves.
Unlike previous research that has tried to control animal movement by applying invasive methods, most notably in insects, Professors Phill-Seung Lee of the Mechanical Engineering Department and Sungho Jo of the Computing School propose a conceptual system that can guide an animal’s moving path by controlling its instinctive escape behavior. They chose a turtle because of its cognitive abilities as well as its ability to distinguish different wavelengths of light. Specifically, turtles can recognize a white light source as an open space and so move toward it. They also show specific avoidance behavior to things that might obstruct their view. Turtles also move toward and away from obstacles in their environment in a predictable manner. It was this instinctive, predictable behavior that the researchers induced using the BCI.
The entire human-turtle setup is as follows: A head-mounted display (HMD) is combined with a BCI to immerse the human user in the turtle’s environment. The human operator wears the BCI-HMD system, while the turtle has a 'cyborg system'—consisting of a camera, Wi-Fi transceiver, computer control module, and battery—all mounted on the turtle’s upper shell. Also included on the turtle’s shell is a black semi-cylinder with a slit, which forms the ‘stimulation device.’ This can be turned ±36 degrees via the BCI.
The entire process works like this: the human operator receives images from the camera mounted on the turtle. These real-time video images allow the human operator to decide where the turtle should move. The human provides thought commands that are recognized by the wearable BCI system as electroencephalography (EEG) signals. The BCI can distinguish between three mental states: left, right, and idle. The left and right commands activate the turtle’s stimulation device via Wi-Fi, turning it so that it obstructs the turtle’s view. This invokes its natural instinct to move toward light and change its direction. Finally, the human acquires updated visual feedback from the camera mounted on the shell and in this way continues to remotely navigate the turtle’s trajectory.
The research demonstrates that the animal guiding scheme via BCI can be used in a variety of environments with turtles moving indoors and outdoors on many different surfaces, like gravel and grass, and tackling a range of obstacles, such as shallow water and trees. This technology could be developed to integrate positioning systems and improved augmented and virtual reality techniques, enabling various applications, including devices for military reconnaissance and surveillance.
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Reference: “Remote Navigation of Turtle by Controlling Instinct Behavior via Human Brain-computer Interface,” Journal of Bionic Engineering, July 2016 (DOI: 10.1016/S1672-6529(16)60322-0)
Depiction of Cyborg System
A human controller influences the turtle’s escape behavior by sending left and right signals via Wi-Fi to a control system on the back of the turtle.
2017.02.21 View 13797 -
An Improved Carbon Nanotube Semiconductor
Professor Yang-Kyu Choi and his research team of the School of Electrical Engineering at KAIST collaborated with Professor Sung-Jin Choi of Kookmin University to develop a large-scale carbon nanotube semiconductor by using a 3-D fin-gate structure with carbon nanotubes on its top.
Dong Il Lee, a postdoctoral researcher at KAIST’s Electrical Engineering School, participated in this study as the first author. It was published in ACS Nano on November 10, 2016, and was entitled “Three-Dimensional Fin-Structured Semiconducting Carbon Nanotube Network Transistor.”
A semiconductor made with carbon nanotubes operates faster than a silicon semiconductor and requires less energy, yielding higher performance.
Most electronic equipment and devices, however, use silicon semiconductors because it is difficult to fabricate highly purified and densely packed semiconductors with carbon nanotubes (CNTs).
To date, the performance of CNTs was limited due to their low density. Their purity was also low, so it was impossible to make products that had a constant yield on a large-surface wafer or substrate. These characteristics made the mass production of semiconducting CNTs difficult.
To solve these difficulties, the research team used a 3-D fin-gate to vapor-deposit carbon nanotubes on its top. They developed a semiconductor that had a high current density with a width less than 50 nm.
The three-dimensional fin structure was able to vapor-deposit 600 carbon nanotubes per micrometer. This structure could have 20 times more nanotubes than the two dimensional structure, which could only vapor-deposit thirty in the same 1 micrometer width.
In addition, the research team used semi-conductive carbon nanotubes having a purity rating higher than 99.9% from a previous study to obtain a high yield semiconductor.
The semiconductor from the research group has a high current density even with a width less than 50 μm. The new semiconductor is expected to be five times faster than a silicon-based semiconductor and will require five times less electricity during operation.
Furthermore, the new semiconductor can be made by or will be compatible with the equipment for producing silicon-based semiconductors, so there will be no additional costs.
Researcher Lee said, “As a next generation semiconductor, the carbon nanotube semiconductor will have better performance, and its effectiveness will be higher.” He also added, “Hopefully, the new semiconductor will replace the silicon-based semiconductors in ten years.”
This study received support from the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT & Future Planning of Korea as the Global Frontier Project, and from the CMOS (Complementary Metal-Oxide-Semiconductor) THz Technology Convergence Center of the Pioneer Research Center Program sponsored by the National Research Foundation of Korea.
Picture 1: 3D Diagram of the Carbon Nanotube Electronic Device and Its Scanning Electron Microscope (SEM) Image
Picture 2: 3D Transistor Device on an 8-inch Base and the SEM Image of Its Cross Section
2017.02.16 View 9617 -
EWB-KAIST Wraps up Five-Year Project in Nepal
‘Engineers Without Borders-KAIST (EWB-KAIST)’ led by Professor Tae-ho Song from the Department of Mechanical Engineering returned to Korea on January 10 after a two-week project in Nangi, Nepal.
EWB-KAIST was established in 2012 by KAIST students and professors. Since then, the team visited Nangi, in the Annapurna region of Nepal, to engage in Appropriate Technology (AT) development projects. The projects included building passive houses and small hydroelectric power, and teaching science education. In particular, passive houses that use straw as an insulator received great a reception from the locals.
This was their last visit to Nepal, since the five-year project has now come to an end. Future projects in Mongolia will be led by Professor Buhm Soon Park from the Graduate School of Science and Technology Policy.
Professor Song commented, “I am glad that the Nepal project was successfully conducted over the last five years. To make sure the support does not end here, I will personally continue to visit the Himalayas to assist the villagers.”
EWB-KAIST is a non-profit organization that conducts activities with the aim of AT development and providing support for less-developed countries in need of the benefits of technology.
( Passive house made of straws by EWB-KAIST team in Nangi, Nepal.)
2017.02.01 View 6269 -
KAIST Joins IoF 2020 with 'Oliot'
KAIST will take part in the Internet of Food & Farm 2020 (IoF 2020) project with its international standard IoT open source platform ‘Oliot’ (Open Language for the Internet of Things, http://oliot.org), developed by a research team under Professor Daeyoung Kim from the School of Computing. Dr. Kim is also the director at the Auto-ID Labs at KAIST (http://autoidlabs.org).
IoF 2020 is a project to provide solutions and facilitate the large-scale uptake of IoT by addressing the organizational and technological challenges the European farming and food sectors face today. The project will develop innovative IoT solutions by fostering co-creation in interactive improvement cycles focusing on user acceptability and business models to boost technology and market-readiness levels.
Along with 71 partners from 16 countries, Professor Kim’s ‘Oliot’ will play a part in creating an ecosystem for providing safe and healthy agrifood, incorporating ICT(information and communications technologies) into the areas of smart farms and the agrifood service sector over the next four years. The project received €30 million in funding from Horizon 2020, the largest research and innovation program in the EU. KAIST is the only Korean institution to participate in this project.
For the project, Professor Kim’s team will initially establish smart farm and food service testbeds for the domestic agrifood industry with ‘Oliot’ prior to connecting to the European one. Professor Kim said he will leverage Artificial Intelligence (AI) and deep learning in order to analyze the data collected from the ecosystems in the EU. He aims to open an integrated IoT platform system incorporated with AI technologies to serve governments, institutions, corporations, and farmers.
It is expected that technologies developed for IoF 2020 will also benefit the domestic agrifood market and its supply chain infrastructure. Oliot will also be expected to further advance domestic smart industries including health care and connected vehicles.
George Beers, project manager at Wageningen University & Research and the IoF 2020 project coordinator said, “IoF 2020 has the potential to transform the paradigm of the supply chain of agrifood from the farm to consumers’ dining tables. We believe this project will contribute to enhance European competitiveness and excellence in the food commerce industry.”
Professor Kim said, “Technological applications of international standard IoT have already started in the domestic agrifood industry in collaboration with KAIST. We are working now with Asian and South American countries, as well as European nations, for the integration of a global agrifood business ecosystem.”
Auto-ID Labs are a global research consortium of seven academic institutions that research and develop new technologies for advancing global commerce, partnering with GS1 (Global Standard 1), a non-profit organization that established standards for global commerce such as introducing barcodes to the retail industry. The Auto-ID Labs include MIT, University of Cambridge, Keio University, Fudan University, and ETH Zurich/University of St. Gallen as well as KAIST.
2017.01.18 View 6946 -
KAIST Undergraduates Win the Innovative Design Contest 2016
A team of KAIST students, consisting of five undergraduates (Do-Hoon Kwon, Tae-Hyun Kim, Hak-Gi Do, Hyun-Joo Lee, and Jong-Ho Jeong) from the Department of Mechanical Engineering, won the grand prize at the Innovative Design Contest held at Osaka University in Japan on December 12-13, 2016. The event took place during the 16th Asia Design Engineering Workshop (A-DEWS).
For this year’s contest, a total of ten student teams from such countries as Korea, Japan, Taiwan, and Malaysia participated, and Team KAIST earned the highest scores. The five KAIST students, all taking the course entitled “Production of Creative Systems,” developed a manual wheelchair accessory called “Safe Attachable Wheelchair Assistive Device in Capstone Design (SAWADiCap).
SAWADiCap is a detachable auxiliary power device that increases the range and mobility of manual wheelchairs. The device can easily be installed and removed, compared to existing add-on attachments for wheelchairs. Users can also enjoy similar advantages offered by powered wheelchairs at a lower cost. In their presentation on the device, the KAIST students introduced their design to improve the power of manual wheelchairs employing the magnetic reinforcement effect and to include the safety features necessary for users to install or operate the device.
Do-Hoon Kwon said, “Our team had a great experience participating in the contest—we met people with diverse backgrounds and expanded our understanding in the field.”
Professor Seibum B. Choi of the Mechanical Engineering Department, who advises the KAIST team, added, “I hope our technology can help the spread of affordable wheelchairs and increase mobility for the disabled.”
Established in 2000, A-DEWS is held annually by the Asian branch of the Design Engineering Workshop to provide an international forum for researchers and practitioners in the field of design engineering by facilitating the exchange of recent research results and sharing knowledge about design strategies and methods. This year’s theme for the workshop was “Innovation of Life.”
A-DEWS hosts the Innovative Design Contest to encourage young engineers, researchers, and students who are creating innovative products, services, and product-services and to show appreciation for their efforts.
Pictured below from left to right are Hyun-Joo Lee, Do-Hoon Kwon, Jong-Ho Jeong, and Hak-Gi Do.
2017.01.03 View 8184 -
KAIST Ph.D. Candidate Wins the Next Generation of Engineers Award
Joo-Sung Kim, a doctoral student at the EEWS (Environment, Energy, Water and Sustainability) Graduate School won the inaugural Next Generation of Engineers Award in Leadership on December 14, 2016.
The National Academy of Engineering of Korea hosts this award to support creative and ambitious students who have the potential to become leaders in engineering and who will serve as role models for future Korean engineers. Based on the recommendations of university professors in engineering and members of the academy, seven students are selected for the award in the categories of leadership and entrepreneurship.
With his research focus on the development of high-performance, next-generation secondary cells for wearable devices such as smart watches, health bands, and smart eyewear, Joo-Sung created a startup, Lithium-ion Battery Energy Science and Technology (LiBEST), Inc. He plans to base his company at the Office of University and Industry Cooperation, KAIST, where he can receive assistance for launching the mass-production system for his technology.
His adviser, Professor Jang-Wook Choi of the EEWS Graduate School, noted, “Joo-Sung has been a great student who has a strong sense of curiosity and perseverance. The award is the by-product of his hard work.”
“I have always enjoyed my work and study as a researcher, but eventually would like to expand my career into business based on the results of my research. It would be wonderful if I could become a businessman like Elon Musk, Masayoshi Son, or Ma Yun and create a role model for aspiring engineers in Korea by combining science and technology with business demand to create social values that benefit many people,” Joo-Young said.
2016.12.26 View 8876 -
EEWS Graduate School Team Receives the S-Oil Best Paper Award
Professor Hyungjun Kim and Dr. He-Young Shin from the EEWS (Energy, Environment, Water and Sustainability) Graduate School at KAIST received the Best Paper Award in Chemistry from S-Oil, a Korean petroleum and refinery company, on November 29, 2016.
Established in 2011, the S-Oil Best Paper Awards are bestowed annually upon ten young scientists in the fields of five basic sciences: mathematics, physics, chemistry, biology, and earth science. The scientists are selected at the recommendation of the Korean Academy of Science and Technology and the Association of Korean Universities. The awards grant a total of USD 230,000 for research funding.
Dr. Shin, the lead author of the awarded research paper, said, “My research interest has been catalyst studies based on theoretical chemistry. I am pleased to accept this award that will support my studies, and will continue to research catalyst design that can predict parameters and integrate them into catalytic systems.”
Professor Hyungjun Kim (left) and Dr. He-Young Shin (right)
2016.12.23 View 8340 -
Professor Dongman Lee Wins the 2016 Korea Internet Award
Professor Dongman Lee of KAIST’s School of Computing received the 11th Korea Internet Award in the category of personal achievement on December 13 at the Creative Economy and Innovation Center in Gyeonggi province.
Hosted by the Ministry of Science, ICT and Future Planning of Korea, the Internet Award recognizes leaders in the Internet industry and their contributions.
Since 2010, Professor Lee has conducted research on the Internet of Things (IoT) platforms, resulting in the publication of five research papers in Science Citation Index (SCI) journals, ten papers in Korean journals, 30 best papers nominations at international conferences, and the registration of eleven patents. He has also worked on the creation of an IoT ecosystem through his research on object interworking platforms that can provide diverse user-customized services in the IoT environment.
His research team built a test bed for applicable IoT platforms on the 8th floor of the IT Convergence Center on campus to implement experiments and collect various data, thereby creating a foundation to carry out research projects in this field.
Professor Lee has helped the advancement of an Internet governance system in Korea by researching Internet governance policies, holding important posts in related academic societies including the Chairman of the Korea Internet Governance Alliance (KIGA) Council, and hosting major conferences such as the Asia Pacific Regional Internet Governance Forum (APrIGF).
2016.12.20 View 7086 -
Professor Suck-Joo Na Receives the 2016 Humboldt Research Award
The Alexander von Humboldt Foundation, established by the German government in 1953, promotes academic cooperation and exchange among scientists and scholars from Germany and abroad. The foundation has bestowed this year's award to Professor Suck-Joo Na of KAIST's Mechanical Engineering Department in recognition of his lifetime achievements.
Professor Na's main interests are in the fields of arc and laser welding, computational fluid dynamics simulation, residual stress and distortion, and design of welded structures. He has received numerous honors and awards including the Research Fellowship Award from the Alexander von Humboldt Foundation (1989), the Excellent Research Paper Award from the Korean Welding and Joining Society (1993), the Charles H. Jennings Memorial Award from the American Welding Society (2003), and the Yoshiaki Arata Award from the International Institute of Welding (2014).
The Humboldt Research Award is granted annually to up to 100 academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future.
The award winners also receive a research grant of 60,000 Euros and are invited to work up to one year with colleagues at research institutions in Germany. Nominations for the award are made only by established academic institutions in Germany.
Professor Na will collaborate with a research team led by Professor Michael Rethmeier at the Berlin-based Federal Institute for Materials Research and Testing (BAM) to conduct research in laser welding and selective laser melting, as well as the mathematical analysis of these manufacturing processes from July 2017 to the end of February 2018.
2016.12.19 View 7067 -
The Antibody That Normalizes Tumor Vessels
Researchers also discover that their antisepsis antibody reduces glioma, lung and breast cancer progression in mice.
A research team at the Center for Vascular Research within the Institute for Basic Science (IBS) discovered that the antisepsis antibody ABTAA (Ang2-Binding and Tie2-Activating Antibody) reduces tumor volume and improves the delivery of anti-cancer drugs. Published in Cancer Cell, this study demonstrates that ABTAA restores the structural and functional integrity of tumor blood vessels in three different tumor models: breast, lungs, and brain.
Blood vessels inside and around an established tumor can be described as a chaotic and dysfunctional labyrinth. While the inner walls of healthy blood vessels are surrounded and supported by endothelial cells and other cells called pericytes, in the established tumor, the endothelial junctions are broken apart and pericytes are also detached. Blood flow into and from the tumor is severely retarded and tumor vessels lacking an intact vessel wall become leaky. This microenvironment causes limited drug delivery to the tumor and leads to inadequate oxygen supply (hypoxia) and even metastasis.
The research team led by Professor Gou-Young Koh at KAIST’s Graduate School of Medical Science and Engineering found that the antibody ABTAA normalizes the tumor vessels and hence, change the whole tumor microenvironment. “We call it normalization of tumor vessels, because it resembles closely the wall architecture of healthy, normal vessels,” explains PARK Jin-Sung, first author of the study. And continues: “Tumor can adapt to hypoxia and get more aggressive, so we tried to prevent this transition by normalizing tumor vessels. ABTAA changes the whole tumor environment, oxygenation status and level of lactate, so that the immune cells and drugs can reach the core regions of the tumor more easily. In this way, we create a favorable ground for tumor treatment.”
In an attempt to generate antibodies targeting the protein Ang2, which is specifically expressed by endothelial cells in stressful conditions like in tumor, the team unexpectedly discovered that ABTAA has a peculiar way of working and a dual function. ABTAA indeed not only blocks Ang2, but also activates Tie2 at the same time. Tie2 is a receptor present on the cell membrane of endothelial cells. ABTAA causes Ang2 to cluster together and to strongly activate Tie2 receptors. “If we activate Tie2, we can efficiently normalize tumor vessels, enhance drug delivery and change the whole microenvironment,” explains KOH Gou Young, Director of the Center for Vascular Research.
Several pharmaceutical companies are developing Ang2-blocking antibodies to cure cancer. However, even if these antibodies significantly inhibit tumor progression, they do not stop tumor hypoxia. Moreover, most of the anti-cancer drugs target the tumor at its early stage, when tumors are still hard to diagnose. ABTAA, instead, works with tumors that are already rooted: “When the tumor is established, hypoxia is the main driver of tumor progression. So, if we eliminate hypoxia, we make the tumor milder, by reducing its progression and metastasis,” comments Koh.
Figure: Schematic drawing of a blood vessel around tumors before and after treatment with ABTAA. The picture above shows a typical tumor vasculature characterized by damaged walls, red blood cells leakage and detached pericytes. Activating Tie2 on endothelial cells with the antibody ABTAA restores the normal vessel architecture: endothelial and pericytes on the vessel walls are stabilized, the delivery of blood is improved, and the anticancer drugs are more likely to reach the tumor core.
The researchers tested ABTAA in mice with three different types of tumors that show high levels of Ang2: glioma (a type of a brain tumor), lung carcinoma, and breast cancer. They also compared the effect of ABTAA with ABA, another antibody that blocks Ang2 but misses the Tie2 activating properties. In all three cases, ABTAA was superior to ABA in inducing tumor vessel normalization, which led to a better delivery of the anti-cancer drugs into the tumor core region.
Glioma is one of the so-called intractable diseases, because of its poor prognosis and treatment. Professor Koh’s team found that the glioma volume was reduced 39% by ABTAA and 17% by ABA. ABTAA profoundly reduced vascular leakage and edema formation in glioma through promoting vascular tightening. Moreover, when ABTAA was administered together with the chemotherapeutic drug temozolomide (TMZ), the tumor volume reduces further (76% by ABTAA+TMZ, 51% by ABA+TMZ, and 36% by TMZ).
In the Lewis Lung Carcinoma (LLC) tumor model, the team administered ABTAA together with a chemotherapeutic drug called cisplatin (Cpt) and observed a greater suppression of tumor growth (52%) compared with the controls and increased overall survival. Moreover, ABTAA+Cpt led to a marked increase in necrotic area within tumors.
Finally, in a spontaneous breast cancer model, ABTAA delayed tumor growth and enhanced the anti-tumor effect of Cpt.
Courtesy of the Institute for Basic Sciences (IBS)
Figure: The antibody ABTAA alone and in combination with other anti-cancer drugs have a beneficial effect in reducing tumor volume. ABTAA was tested in mice with brain tumor (glioma), lung or breast cancer. The image shows the improvements: reduction in glioma tumor size, reduction in metastatic colonies in lung tumor and decrease in necrotic regions in breast tumor.
In the future, the team would like to further understand the underlying relationship between faulty blood vessels and diseases. “We would like to apply this antibody to an organ that is rich in blood vessels, that is the eye, and see if this antibody can be useful to treat eye diseases such as age-related macular degeneration and diabetic retinopathy,” concludes Koh.
Professor Gou-Young Koh (left) and Jin-Sung Park (right)
2016.12.16 View 8224