KAIST

<(From left) Ph. D Candidate Ju Yeon Chung, Prof.Hyun Jung Chung, Ph.D candidate Seungju Yang, Ph.D candidate Ayoung Park, Dr. Yoon-Kyoung Hong from Asan Medical Center, Prof. Yong Pil Chong, Dr. Eunhee Jeon> Candida, a type of fungus, which can spread throughout the body via the bloodstream, leading to organ damage and sepsis. Recently, the incidence of candidiasis has surged due to the increase in immunosuppressive therapies, medical implants, and transplantation. Korean researchers have successfully developed a next-generation treatment that, unlike existing antifungals, selectively acts only on Candida, achieving both high therapeutic efficacy and low side effects simultaneously. KAIST (President Kwang Hyung Lee) announced on the 8th that a research team led by Professor Hyun-Jung Chung of the Department of Biological Sciences, in collaboration with Professor Yong Pil Jeong's team at Asan Medical Center, developed a gene-based nanotherapy (FTNx) that simultaneously inhibits two key enzymes in the Candida cell wall. Current antifungal drugs for Candida have low target selectivity, which can affect human cells. Furthermore, their therapeutic efficacy is gradually decreasing due to the emergence of new resistant strains. Especially for immunocompromised patients, the infection progresses rapidly and has a poor prognosis, making the development of new treatments to overcome the limitations of existing therapies urgent. The developed treatment can be administered systemically, and by combining gene suppression technology with nanomaterial technology, it effectively overcomes the structural limitations of existing compound-based drugs and successfully achieves selective treatment against only Candida. The research team created a gold nanoparticle-based complex loaded with short DNA fragments called antisense oligonucleotides (ASO), which simultaneously target two crucial enzymes—β-1,3-glucan synthase (FKS1) and chitin synthase (CHS3)—important for forming the cell wall of the Candida fungus. By applying a surface coating technology that binds to a specific glycolipid structure (a structure combining sugar and fat) on the Candida cell wall, a targeted delivery device was implemented. This successfully achieved a precise targeting effect, ensuring the complex is not delivered to human cells at all but acts selectively only on Candida. <Figure 1: Overview of antifungal therapy design and experimental approach> This complex, after entering Candida cells, cleaves the mRNA produced by the FKS1 and CHS3 genes, thereby inhibiting translation and simultaneously blocking the synthesis of cell wall components β-1,3-glucan and chitin. As a result, the Candida cell wall loses its structural stability and collapses, suppressing bacterial survival and proliferation. In fact, experiments using a systemic candidiasis model in mice confirmed the therapeutic effect: a significant reduction in Candida count in the organs, normalization of immune responses, and a notable increase in survival rates were observed in the treated group. Professor Hyun-Jung Chung, who led the research, stated, "This study presents a method to overcome the issues of human toxicity and drug resistance spread with existing treatments, marking an important turning point by demonstrating the applicability of gene therapy for systemic infections". She added, "We plan to continue research on optimizing administration methods and verifying toxicity for future clinical application." This research involved Ju Yeon Chung and Yoon-Kyoung Hong as co-first authors , and was published in the international journal 'Nature Communications' on July 1st. Paper Title: Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis DOI: 10.1038/s41467-025-60684-7 This research was supported by the Ministry of Health and Welfare and the National Research Foundation of Korea.  

<(From the left) Prof. Hyun Uk Kim, Ph.D candiate Hae Deok Jung, Ph.D candidate Jina Lim, Prof.Yoosik Kim from the Department of Chemical and Biomolecular Engineering> One of the biggest obstacles in cancer treatment is drug resistance in cancer cells. Conventional efforts have focused on identifying new drug targets to eliminate these resistant cells, but such approaches can often lead to even stronger resistance. Now, researchers at KAIST have developed a computational framework to predict key metabolic genes that can re-sensitize resistant cancer cells to treatment. This technique holds promise not only for a variety of cancer therapies but also for treating metabolic diseases such as diabetes. On the 7th of July, KAIST (President Kwang Hyung Lee) announced that a research team led by Professors Hyun Uk Kim and Yoosik Kim from the Department of Chemical and Biomolecular Engineering had developed a computational framework that predicts metabolic gene targets to re-sensitize drug-resistant breast cancer cells. This was achieved using a metabolic network model capable of simulating human metabolism. Focusing on metabolic alterations—key characteristics in the formation of drug resistance—the researchers developed a metabolism-based approach to identify gene targets that could enhance drug responsiveness by regulating the metabolism of drug-resistant breast cancer cells. < Computational framework that can identify metabolic gene targets to revert the metabolic state of the drug-resistant cells to that of the drug-sensitive parental cells> The team first constructed cell-specific metabolic network models by integrating proteomic data obtained from two different types of drug-resistant MCF7 breast cancer cell lines: one resistant to doxorubicin and the other to paclitaxel. They then performed gene knockout simulations* on all of the metabolic genes and analyzed the results.  *Gene knockout simulation: A computational method to predict changes in a biological network by virtually removing specific genes. As a result, they discovered that suppressing certain genes could make previously resistant cancer cells responsive to anticancer drugs again. Specifically, they identified GOT1 as a target in doxorubicin-resistant cells, GPI in paclitaxel-resistant cells, and SLC1A5 as a common target for both drugs. The predictions were experimentally validated by suppressing proteins encoded by these genes, which led to the re-sensitization of the drug-resistant cancer cells. Furthermore, consistent re-sensitization effects were also observed when the same proteins were inhibited in other types of breast cancer cells that had developed resistance to the same drugs. Professor Yoosik Kim remarked, “Cellular metabolism plays a crucial role in various intractable diseases including infectious and degenerative conditions. This new technology, which predicts metabolic regulation switches, can serve as a foundational tool not only for treating drug-resistant breast cancer but also for a wide range of diseases that currently lack effective therapies.” Professor Hyun Uk Kim, who led the study, emphasized, “The significance of this research lies in our ability to accurately predict key metabolic genes that can make resistant cancer cells responsive to treatment again—using only computer simulations and minimal experimental data. This framework can be widely applied to discover new therapeutic targets in various cancers and metabolic diseases.” The study, in which Ph.D. candidates JinA Lim and Hae Deok Jung from KAIST participated as co-first authors, was published online on June 25 in Proceedings of the National Academy of Sciences (PNAS), a leading multidisciplinary journal that covers top-tier research in life sciences, physics, engineering, and social sciences. ※ Title: Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets ※ DOI: https://doi.org/10.1073/pnas.2425384122 ※ Authors: JinA Lim (KAIST, co-first author), Hae Deok Jung (KAIST, co-first author), Han Suk Ryu (Seoul National University Hospital, corresponding author), Yoosik Kim (KAIST, corresponding author), Hyun Uk Kim (KAIST, corresponding author), and five others. This research was supported by the Ministry of Science and ICT through the National Research Foundation of Korea, and the Electronics and Telecommunications Research Institute (ETRI).    

    Latest generative AI models such as OpenAI's ChatGPT-4 and Google's Gemini 2.5 require not only high memory bandwidth but also large memory capacity. This is why generative AI cloud operating companies like Microsoft and Google purchase hundreds of thousands of NVIDIA GPUs. As a solution to address the core challenges of building such high-performance AI infrastructure, Korean researchers have succeeded in developing an NPU (Neural Processing Unit)* core technology that improves the inference performance of generative AI models by an average of over 60% while consuming approximately 44% less power compared to the latest GPUs. *NPU (Neural Processing Unit): An AI-specific semiconductor chip designed to rapidly process artificial neural networks.   On the 4th, Professor Jongse Park's research team from KAIST School of Computing, in collaboration with HyperAccel Inc. (a startup founded by Professor Joo-Young Kim from the School of Electrical Engineering), announced that they have developed a high-performance, low-power NPU (Neural Processing Unit) core technology specialized for generative AI clouds like ChatGPT. The technology proposed by the research team has been accepted by the '2025 International Symposium on Computer Architecture (ISCA 2025)', a top-tier international conference in the field of computer architecture. The key objective of this research is to improve the performance of large-scale generative AI services by lightweighting the inference process, while minimizing accuracy loss and solving memory bottleneck issues. This research is highly recognized for its integrated design of AI semiconductors and AI system software, which are key components of AI infrastructure. While existing GPU-based AI infrastructure requires multiple GPU devices to meet high bandwidth and capacity demands, this technology enables the configuration of the same level of AI infrastructure using fewer NPU devices through KV cache quantization*. KV cache accounts for most of the memory usage, thereby its quantization significantly reduces the cost of building generative AI clouds. *KV Cache (Key-Value Cache) Quantization: Refers to reducing the data size in a type of temporary storage space used to improve performance when operating generative AI models (e.g., converting a 16-bit number to a 4-bit number reduces data size by 1/4). The research team designed it to be integrated with memory interfaces without changing the operational logic of existing NPU architectures. This hardware architecture not only implements the proposed quantization algorithm but also adopts page-level memory management techniques* for efficient utilization of limited memory bandwidth and capacity, and introduces new encoding technique optimized for quantized KV cache. *Page-level memory management technique: Virtualizes memory addresses, as the CPU does, to allow consistent access within the NPU. Furthermore, when building an NPU-based AI cloud with superior cost and power efficiency compared to the latest GPUs, the high-performance, low-power nature of NPUs is expected to significantly reduce operating costs. Professor Jongse Park stated, "This research, through joint work with HyperAccel Inc., found a solution in generative AI inference lightweighting algorithms and succeeded in developing a core NPU technology that can solve the 'memory problem.' Through this technology, we implemented an NPU with over 60% improved performance compared to the latest GPUs by combining quantization techniques that reduce memory requirements while maintaining inference accuracy, and hardware designs optimized for this". He further emphasized, "This technology has demonstrated the possibility of implementing high-performance, low-power infrastructure specialized for generative AI, and is expected to play a key role not only in AI cloud data centers but also in the AI transformation (AX) environment represented by dynamic, executable AI such as 'Agentic AI'."     This research was presented by Ph.D. student Minsu Kim and Dr. Seongmin Hong from HyperAccel Inc. as co-first authors at the '2025 International Symposium on Computer Architecture (ISCA)' held in Tokyo, Japan, from June 21 to June 25. ISCA, a globally renowned academic conference, received 570 paper submissions this year, with only 127 papers accepted (an acceptance rate of 22.7%). ※Paper Title: Oaken: Fast and Efficient LLM Serving with Online-Offline Hybrid KV Cache Quantization ※DOI: https://doi.org/10.1145/3695053.3731019 Meanwhile, this research was supported by the National Research Foundation of Korea's Excellent Young Researcher Program, the Institute for Information & Communications Technology Planning & Evaluation (IITP), and the AI Semiconductor Graduate School Support Project.  

<(From left)Professor Kyung Cheol Choi,  Hyunjoo J. Lee, Somin Lee from the School of Electrical Engineering> Optogenetics is a technique that controls neural activity by stimulating neurons expressing light-sensitive proteins with specific wavelengths of light. It has opened new possibilities for identifying causes of brain disorders and developing treatments for intractable neurological diseases. Because this technology requires precise stimulation inside the human brain with minimal damage to soft brain tissue, it must be integrated into a neural probe—a medical device implanted in the brain. KAIST researchers have now proposed a new paradigm for neural probes by integrating micro OLEDs into thin, flexible, implantable medical devices. KAIST (President Kwang Hyung Lee) announced on the 6th of July that Professor Kyung Cheol Choi and researcher Hyunjoo J. Lee from the School of Electrical Engineering have jointly succeeded in developing an optogenetic neural probe integrated with flexible micro OLEDs. Optical fibers have been used for decades in optogenetic research to deliver light to deep brain regions from external light sources. Recently, research has focused on flexible optical fibers and ultra-miniaturized neural probes that integrate light sources for single-neuron stimulation. The research team focused on micro OLEDs due to their high spatial resolution and flexibility, which allow for precise light delivery to small areas of neurons. This enables detailed brain circuit analysis while minimizing side effects and avoiding restrictions on animal movement. Moreover, micro OLEDs offer precise control of light wavelengths and support multi-site stimulation, making them suitable for studying complex brain functions. However, the device's electrical properties degrade easily in the presence of moisture or water, which limited their use as implantable bioelectronics. Furthermore, optimizing the high-resolution integration process on thin, flexible probes remained a challenge. To address this, the team enhanced the operational reliability of OLEDs in moist, oxygen-rich environments and minimized tissue damage during implantation. They patterned an ultrathin, flexible encapsulation layer* composed of aluminum oxide and parylene-C (Al₂O₃/parylene-C) at widths of 260–600 micrometers (μm) to maintain biocompatibility.  *Encapsulation layer: A barrier that completely blocks oxygen and water molecules from the external environment, ensuring the longevity and reliability of the device. When integrating the high-resolution micro OLEDs, the researchers also used parylene-C, the same biocompatible material as the encapsulation layer, to maintain flexibility and safety. To eliminate electrical interference between adjacent OLED pixels and spatially separate them, they introduced a pixel define layer (PDL), enabling the independent operation of eight micro OLEDs. Furthermore, they precisely controlled the residual stress and thickness in the multilayer film structure of the device, ensuring its flexibility even in biological environments. This optimization allowed for probe insertion without bending or external shuttles or needles, minimizing mechanical stress during implantation. Advanced Functional Materials-Conceptual diagram of a flexible neural probe for integrated optogenetics (Micro-OLED)> As a result, the team developed a flexible neural probe with integrated micro OLEDs capable of emitting more than one milliwatt per square millimeter (mW/mm²) at 470 nanometers (nm), the optimal wavelength for activating channelrhodopsin-2. This is a significantly high light output for optogenetics and biomedical stimulation applications. The ultrathin flexible encapsulation layer exhibited a low water vapor transmission rate of 2.66×10⁻⁵ g/m²/day, allowing the device to maintain functionality for over 10 years. The parylene-C-based barrier also demonstrated excellent performance in biological environments, successfully enabling the independent operation of the integrated OLEDs without electrical interference or bending issues. Dr. Somin Lee, the lead author from Professor Choi’s lab, stated, “We focused on fine-tuning the integration process of highly flexible, high-resolution micro OLEDs onto thin flexible probes, enhancing their biocompatibility and application potential. This is the first reported development of such flexible OLEDs in a probe format and presents a new paradigm for using flexible OLEDs as implantable medical devices for monitoring and therapy.” This study, with Dr. Somin Lee as the first author, was published online on March 26 in Advanced Functional Materials (IF 18.5), a leading international journal in the field of nanotechnology, and was selected as the cover article for the upcoming July issue.  ※ Title: Advanced Micro-OLED Integration on Thin and Flexible Polymer Neural Probes for Targeted Optogenetic Stimulation ※ DOI: https://doi.org/10.1002/adfm.202420758 The research was supported by the Ministry of Science and ICT and the National Research Foundation of Korea through the Electronic Medicine Technology Development Program (Project title: Development of Core Source Technologies and In Vivo Validation for Brain Cognition and Emotion-Enhancing Light-Stimulating Electronic Medicine).

<(From Left)Prof. Yong Man Ro and Ph.D. candidate Sejin Park> Se Jin Park, a researcher from Professor Yong Man Ro’s team at KAIST, has announced 'SpeechSSM', a spoken language model capable of generating long-duration speech that sounds natural and remains consistent. An efficient processing technique based on linear sequence modeling overcomes the limitations of existing spoken language models, enabling high-quality speech generation without time constraints. It is expected to be widely used in podcasts, audiobooks, and voice assistants due to its ability to generate natural, long-duration speech like humans. Recently, Spoken Language Models (SLMs) have been spotlighted as next-generation technology that surpasses the limitations of text-based language models by learning human speech without text to understand and generate linguistic and non-linguistic information. However, existing models showed significant limitations in generating long-duration content required for podcasts, audiobooks, and voice assistants. Now, KAIST researcher has succeeded in overcoming these limitations by developing 'SpeechSSM,' which enables consistent and natural speech generation without time constraints. KAIST(President Kwang Hyung Lee) announced on the 3rd of July that Ph.D. candidate Sejin Park from Professor Yong Man Ro's research team in the School of Electrical Engineering has developed 'SpeechSSM,' a spoken. a spoken language model capable of generating long-duration speech.   This research is set to be presented as an oral paper at ICML (International Conference on Machine Learning) 2025, one of the top machine learning conferences, selected among approximately 1% of all submitted papers. This not only proves outstanding research ability but also serves as an opportunity to once again demonstrate KAIST's world-leading AI research capabilities.   A major advantage of Spoken Language Models (SLMs) is their ability to directly process speech without intermediate text conversion, leveraging the unique acoustic characteristics of human speakers, allowing for the rapid generation of high-quality speech even in large-scale models. However, existing models faced difficulties in maintaining semantic and speaker consistency for long-duration speech due to increased 'speech token resolution' and memory consumption when capturing very detailed information by breaking down speech into fine fragments. To solve this problem, Se Jin Park developed 'SpeechSSM,' a spoken language model using a Hybrid State-Space Model, designed to efficiently process and generate long speech sequences. This model employs a 'hybrid structure' that alternately places 'attention layers' focusing on recent information and 'recurrent layers' that remember the overall narrative flow (long-term context). This allows the story to flow smoothly without losing coherence even when generating speech for a long time. Furthermore, memory usage and computational load do not increase sharply with input length, enabling stable and efficient learning and the generation of long-duration speech. SpeechSSM effectively processes unbounded speech sequences by dividing speech data into short, fixed units (windows), processing each unit independently, and then combining them to create long speech. Additionally, in the speech generation phase, it uses a 'Non-Autoregressive' audio synthesis model (SoundStorm), which rapidly generates multiple parts at once instead of slowly creating one character or one word at a time, enabling the fast generation of high-quality speech. While existing models typically evaluated short speech models of about 10 seconds, Se Jin Park created new evaluation tasks for speech generation based on their self-built benchmark dataset, 'LibriSpeech-Long,' capable of generating up to 16 minutes of speech. Compared to PPL (Perplexity), an existing speech model evaluation metric that only indicates grammatical correctness, she proposed new evaluation metrics such as 'SC-L (semantic coherence over time)' to assess content coherence over time, and 'N-MOS-T (naturalness mean opinion score over time)' to evaluate naturalness over time, enabling more effective and precise evaluation. Through these new evaluations, it was confirmed that speech generated by the SpeechSSM spoken language model consistently featured specific individuals mentioned in the initial prompt, and new characters and events unfolded naturally and contextually consistently, despite long-duration generation. This contrasts sharply with existing models, which tended to easily lose their topic and exhibit repetition during long-duration generation. PhD candidate Sejin Park explained, "Existing spoken language models had limitations in long-duration generation, so our goal was to develop a spoken language model capable of generating long-duration speech for actual human use." She added, "This research achievement is expected to greatly contribute to various types of voice content creation and voice AI fields like voice assistants, by maintaining consistent content in long contexts and responding more efficiently and quickly in real time than existing methods." This research, with Se Jin Park as the first author, was conducted in collaboration with Google DeepMind and is scheduled to be presented as an oral presentation at ICML (International Conference on Machine Learning) 2025 on July 16th. Paper Title: Long-Form Speech Generation with Spoken Language Models DOI: 10.48550/arXiv.2412.18603   Ph.D. candidate Se Jin Park has demonstrated outstanding research capabilities as a member of Professor Yong Man Ro's MLLM (multimodal large language model) research team, through her work integrating vision, speech, and language. Her achievements include a spotlight paper presentation at 2024 CVPR (Computer Vision and Pattern Recognition) and an Outstanding Paper Award at 2024 ACL (Association for Computational Linguistics). For more information, you can refer to the publication and accompanying demo: SpeechSSM Publications.

<From left> President Abdulla Al-Salman(King Saud University), President Kwang Hyung Lee(KAIST) KAIST (President Kwang Hyung Lee) and King Saud University (President Abdulla Al-Salman) held a meeting on July 3 at the KAIST Campus in Seoul and agreed to pursue strategic cooperation in AI and digital platform development. The global AI landscape is increasingly polarized between closed models developed by the U.S. and China’s nationally focused technology ecosystems. In this context, many neutral countries have consistently called for an alternative third model that promotes both technological diversity and open access. President Lee has previously advocated for a "Tripartite Platform Strategy" (三分之計), proposing an international collaboration framework based on open-source principles to be free from binary digital power structures and foster cooperative coexistence. This KAIST-KSU collaboration represents a step toward developing a new, inclusive AI model. The collaboration aims to establish an innovative multilateral framework, especially within the MENA, Japan, Korea, and Southeast Asia, by building an open-source-based AI alliance. Both institutions bring complementary strengths to the table. Saudi Arabia possesses large-scale capital and digital infrastructure, while Korea leads in core AI and semiconductor technologies, applied research, and talent cultivation. Together, the two nations aim to establish a sustainable collaboration model that creates a virtuous cycle of investment, technology, and talent. This initiative is expected to contribute to the development of an open AI platform and promote diversity in the global AI ecosystem. During the meeting, the two sides discussed key areas of future cooperation, including: ·         Joint development of open-source AI technologies and digital platforms ·         Launch of a KAIST-KSU dual graduate degree program ·         Expansion of exchange programs for students, faculty, and researchers ·         Collaborative research in basic science and STEM disciplines In particular, the two institutions discussed to establish a joint AI research center to co-develop open AI models and explore practical industrial applications. The goal is to broaden access to AI technology and create an inclusive innovation environment for more countries and institutions. President Abdulla Al-Salman stated, "Under Saudi Vision 2030, we are driving innovation in science and technology through new leadership, openness, and strategic investment. This partnership with KAIST will serve as a critical foundation for building a competitive AI ecosystem in the Middle East." President Kwang Hyung Lee emphasized, "By combining Saudi Arabia's leadership, market, and investment capacity with KAIST's technological innovation and the rich talent pools from both countries, we will significantly contribute to diversifying the global AI ecosystem." Both leaders further noted, "Through joint research leading to an independent AI model, our two institutions could establish a new axis beyond the existing US-China digital order—realizing a 'Tripartite AI Strategy' that will propel us into global markets extending far beyond the MENA and ASEAN regions." KAIST and KSU plan to formalize this agreement by signing an MOU in the near future, followed by concrete actions such as launching the joint research institute and global talent development programs. This collaboration was initiated under the Korea Foundation’s Distinguished Guests Invitation Program, overseen by the Ministry of Foreign Affairs, and is expected to grow into a long-term strategic partnership with continued support from KF. About King Saud University (KSU) Founded in 1957, KSU is Saudi Arabia’s first and leading national university. As a top research-oriented institution in the Middle East, it has achieved international recognition in fields such as AI, energy, and biotechnology. It plays a central role in nurturing talent and driving innovation aligned with Saudi Arabia’s Vision 2030, and is expanding global partnerships to further strengthen its research capabilities. About the Korea Foundation (KF) Established in 1991 under the Ministry of Foreign Affairs, the Korea Foundation is a public diplomacy institution dedicated to strengthening international understanding and friendship with Korea. KF plays a key role in expanding Korea’s soft power through academic and cultural exchange, people-to-people networks, and global Korean studies programs. Its Distinguished Guests Invitation Program fosters strategic partnerships with global leaders in government, academia, and industry.      

* Focusing on nurturing talent and dedicating to R&D to become a G3 AI powerhouse (Top 3 AI Nations). * Leading the realization of an "AI-driven Basic Society for All" and developing technologies that leverage AI to overcome the crisis in Korea's manufacturing sector. * 50 years ago, South Korea emerged as a scientific and technological powerhouse from the ashes, with KAIST at its core, contributing to the development of scientific and technological talent, innovative technology, national industrial growth, and the creation of a startup innovation ecosystem. As public interest in AI and science and technology has significantly grown with the inauguration of the new government, KAIST (President Kwang Hyung Lee) announced its plan, on June 24th, to transform into an "AI-centric, Value-Creating Science and Technology University" that leads national innovation based on science and technology and spearheads solutions to global challenges. At a time when South Korea is undergoing a major transition to a technology-driven society, KAIST, drawing on its half-century of experience as a "Starter Kit" for national development, is preparing to leap beyond being a mere educational and research institution to become a global innovation hub that creates new social value. In particular, KAIST has presented a vision for realizing an "AI-driven Basic Society" where all citizens can utilize AI without alienation, enabling South Korea to ascend to the top three AI nations (G3). To achieve this, through the "National AI Research Hub" project (headed by Kee Eung Kim), led by KAIST representing South Korea, the institution is dedicated to enhancing industrial competitiveness and effectively solving social problems based on AI technology. < KAIST President Kwang Hyung Lee > KAIST's research achievements in the AI field are garnering international attention. In the top three machine learning conferences (ICML, NeurIPS, ICLR), KAIST ranked 5th globally and 1st in Asia over the past five years (2020-2024). During the same period, based on the number of papers published in top conferences in machine learning, natural language processing, and computer vision (ICML, NeurIPS, ICLR, ACL, EMNLP, NAACL, CVPR, ICCV, ECCV), KAIST ranked 5th globally and 4th in Asia. Furthermore, KAIST has consistently demonstrated unparalleled research capabilities, ranking 1st globally in the average number of papers accepted at ISSCC (International Solid-State Circuits Conference), the world's most prestigious academic conference on semiconductor integrated circuits, for 19 years (2006-2024). KAIST is continuously expanding its research into core AI technologies, including hyper-scale AI models (Korean LLM), neuromorphic semiconductors, and low-power AI processors, as well as various application areas such as autonomous driving, urban air mobility (UAM), precision medicine, and explainable AI (XAI). In the manufacturing sector, KAIST's AI technologies are also driving on-site innovation. Professor Young Jae Jang's team has enhanced productivity in advanced manufacturing fields like semiconductors and displays through digital twins utilizing manufacturing site data and AI-based prediction technology. Professor Song Min Kim's team developed ultra-low power wireless tag technology capable of tracking locations with sub-centimeter precision, accelerating the implementation of smart factories. Technologies such as industrial process optimization and equipment failure prediction developed by INEEJI Co., Ltd., founded by Professor Jaesik Choi, are being rapidly applied in real industrial settings, yielding results. INEEJI was designated as a national strategic technology in the 'Explainable AI (XAI)' field by the government in March. < Researchers performing data analysis for AI research > Practical applications are also emerging in the robotics sector, which is closely linked to AI. Professor Jemin Hwangbo's team from the Department of Mechanical Engineering garnered attention by newly developing RAIBO 2, a quadrupedal robot usable in high-risk environments such as disaster relief and rough terrain exploration. Professor Kyoung Chul Kong's team and Angel Robotics Co., Ltd. developed the WalkOn Suit exoskeleton robot, significantly improving the quality of life for individuals with complete lower body paralysis or walking disabilities. Additionally, remarkable research is ongoing in future core technology areas such as AI semiconductors, quantum cryptography communication, ultra-small satellites, hydrogen fuel cells, next-generation batteries, and biomimetic sensors. Notably, space exploration technology based on small satellites, asteroid exploration projects, energy harvesting, and high-speed charging technologies are gaining attention. Particularly in advanced bio and life sciences, KAIST is collaborating with Germany's Merck company on various research initiatives, including synthetic biology and mRNA. KAIST is also contributing to the construction of a 430 billion won Merck Bio-Center in Daejeon, thereby stimulating the local economy and creating jobs. Based on these cutting-edge research capabilities, KAIST continues to expand its influence not only within the industry but also on the global stage. It has established strategic partnerships with leading universities worldwide, including MIT, Stanford University, and New York University (NYU). Notably, KAIST and NYU have established a joint campus in New York to strengthen human exchange and collaborative research. Active industry-academia collaborations with global companies such as Google, Intel, and TSMC are also ongoing, playing a pivotal role in future technology development and the creation of an innovation ecosystem. These activities also lead to a strong startup ecosystem that drives South Korean industries. The flow of startups, which began with companies like Qnix Computer, Nexon, and Naver, has expanded to a total of 1,914 companies to date. Their cumulative assets amount to 94 trillion won, with sales reaching 36 trillion won and employing approximately 60,000 people. Over 90% of these are technology-based startups originating from faculty and student labs, demonstrating a model that makes a tangible economic contribution based on science and technology. < Students at work > Having consistently generated diverse achievements, KAIST has already produced approximately 80,000 "KAISTians" who have created innovation through challenge and failure, and is currently recruiting new talent to continue driving innovation that transforms South Korea and the world. President Kwang Hyung Lee emphasized, "KAIST will establish itself as a global leader in science and technology, designing the future of South Korea and humanity and creating tangible value." He added, "We will focus on talent nurturing and research and development to realize the new government's national agenda of becoming a G3 AI powerhouse." He further stated, "KAIST's vision for the AI field, in which it places particular emphasis, is to strive for a society where everyone can freely utilize AI. We will contribute to significantly boosting productivity by recovering manufacturing competitiveness through AI and actively disseminating physical AI, AI robots, and AI mobility technologies to industrial sites."

< Distinguished Professor Sang Yup Lee (Senior Vice President for Research) from the Department of Chemical & Biomolecular Engineering > KAIST announced on the 20th that Professor Sang Yup Lee, who serves as the Vice President for Research and a Distinguished Professor at our university, has been awarded the '2025 Gregory N. Stephanopoulos Award for Metabolic Engineering' by the International Metabolic Engineering Society (IMES). Professor Lee delivered his award lecture at the 16th Metabolic Engineering Conference (ME16), held in Copenhagen, Denmark, from June 15th to 19th. This award was established through contributions from the American Institute of Chemical Engineers (AIChE) Foundation, as well as fellow colleagues and acquaintances, to honor the achievements of Dr. Gregory Stephanopoulos, widely recognized as one of the pioneers of metabolic engineering. Presented biennially, the award recognizes scientists who have successfully commercialized fundamental research in metabolic engineering or have made outstanding contributions to the quantitative analysis, design, and modeling of metabolic pathways. Professor Sang Yup Lee boasts an impressive record of over 770 journal papers and more than 860 patents. His groundbreaking research in metabolic engineering and biochemical engineering is highly acclaimed globally. Throughout his 31 years as a professor at KAIST, Professor Lee has developed various metabolic engineering-based technologies and strategies. These advancements have been transferred to industries, facilitating the production of bulk chemicals, polymers, natural products, pharmaceuticals, and health functional foods. He has also founded companies and actively engages in advisory roles with various enterprises. The International Metabolic Engineering Society (IMES) defines metabolic engineering as the manipulation of metabolic pathways in microorganisms or cells to produce useful substances (such as pharmaceuticals, biofuels, and chemical products). It utilizes tools like systems biology, synthetic biology, and computational modeling with the aim of enhancing the economic viability and sustainability of bio-based processes. Furthermore, Professor Lee previously received the Merck Metabolic Engineering Award, a prominent international award in the field, in 2008. In 2018, he was honored with the Eni Award, often referred to as the Nobel Prize in energy, presented by the President of Italy. Professor Sang Yup Lee remarked, "Metabolic engineering is a discipline that leads the current and future of biotechnology. It is a tremendous honor to receive this meaningful award at a time when the transition to a bio-based economy is accelerating. Together with my students and fellow researchers, we have generated numerous patents and transferred technologies to industry, and also established startups in the fields of biofuels, wound healing, and cosmetics. I will continue to pursue research that encompasses both fundamental research and technological commercialization." The 'International Metabolic Engineering Society (IMES)' is a specialized society under the American Institute of Chemical Engineers. Its mission is to enable the production of various bio-based products, including pharmaceuticals, food additives, chemicals, and fuels, through metabolic engineering. The society hosts the Metabolic Engineering Conference biennially, offering researchers opportunities for knowledge exchange and collaboration.

KAIST announced on the 16th of June that it has launched the ‘InnoCORE (Innovation-Core) Research Group,’ which will lead advanced strategic research in AI convergence (AI+S&T), in cooperation with the Ministry of Science and ICT (Minister Yoo Sang-im, hereinafter referred to as MSIT) and DGIST, GIST, and UNIST*. Through this, the group plans to actively recruit up to 200 world-class postdoctoral researchers. DGIST (Daegu Gyeongbuk Institute of Science & Technology), GIST (Gwangju Institute of Science & Technology), UNIST (Ulsan National Institute of Science and Technology) The ‘InnoCORE Research Group’ aims to foster core research personnel who will lead innovation in the field of AI convergence, focusing on nurturing and attracting high-level research talent in AI+Science & Technology. This is a strategic response to prevent brain drain of domestic talent and attract excellent overseas talent amidst the accelerating global competition for AI talent. Through this initiative, our university plans to accelerate AI-based science and technology innovation and disseminate research achievements across industries and the economy by supporting top domestic and international postdoctoral researchers to dedicate themselves to developing AI convergence technologies in an advanced collaborative research environment. The InnoCORE project for advanced AI+S&T convergence research and global talent attraction is jointly promoted by four science and technology institutes, including KAIST. It is structured around AI core technologies (such as hyper-scale language models, AI semiconductors) and AI convergence technologies (such as bio, manufacturing, energy, and aerospace). As the leading institution, our university operates the following four research groups: Hyper-scale Language Model Innovation Research Group: Advancement of LLM technology and research on generative AI, multimodal AI, and ensuring reliability. AI-based Intelligent Design-Manufacturing Integration Research Group: Establishment of an AI platform for the entire lifecycle of the manufacturing industry and innovation in design and processes. AI-Innovation Drug Research Group: Securing AI-based drug development technologies across the entire lifecycle and overcoming intractable diseases. AI-Transformed Aerospace Research Group: AI transformation of aerospace systems throughout their lifecycle and development of new technologies such as autonomous flight and space communication. < Poster on the InnoCORE Global Jobfair for Recruitment of Postdoctoral Researchers > In addition, a total of eight research groups are formed to promote global collaborative convergence research, including those led by DGIST, GIST, and UNIST: ▲Bio-Integrated Physical AI, ▲Early Diagnosis of Brain Diseases AI+Nano Convergence, ▲Intelligent Hydrogen Technology Innovation, and ▲AI-Space Solar Power Research Group. Starting in 2025, the four science and technology institutes, including KAIST, will officially begin recruiting 400 postdoctoral researchers in the AI+S&T fields. Selected postdoctoral researchers will be guaranteed high-level treatment with an annual salary of over 90 million KRW, and additional support through matching with companies and research projects is also planned. In particular, global recruitment fairs will be held in major US regions to expand the attraction of excellent overseas talent. Local recruitment fairs will be held in Boston (Harvard, MIT), New York (NYU), and Silicon Valley (Stanford) in June, along with promotions through global academic journals such as Nature and Science, and LinkedIn. KAIST plans to provide multiple mentor programs, global joint research opportunities, and excellent infrastructure (such as supercomputers, semiconductor fabs, and AI research platforms) within the research groups to enable postdoctoral researchers to collaborate with experts from various academic and industrial fields. President Kwang Hyung Lee emphasized, “Through this InnoCORE project, KAIST will leap forward as a Global Hub for AI+S&T convergence research. Young researchers from around the world will challenge themselves and grow at KAIST, and our country will play a pivotal role in establishing itself as a leading nation in global AI convergence research and industry. To achieve this, we will spare no effort in providing the best research environment and active support.” KAIST plans to actively pursue the InnoCORE project to secure global competitiveness in AI convergence research and contribute to the development of advanced industries. The eight selected research groups will finalize their detailed research plans by the end of June and commence full-scale research in July.

KAIST held a ceremony to declare their renewed "Commitment for Ethical Management" to raise awareness and solidify the commitment its members to faithfully fulfill ethical responsibilities and duties. Last March, the university established the 'Special Committee for Ethical Management,' chaired by the Provost, and under the leadership of this committee, a new 'Code of Ethics' and 'Code of Conduct' were prepared, containing ethical standards that members must adhere to across all areas of education, research, and administration. < Photo 1. Attendees pledge to practice ethics during the declaration for the ethical management. > This ceremony was arranged as an occasion for the president, key executives, and representatives from each university constituent to share the purpose and direction of the newly established ethical standards and to pledge their commitment to practicing them. The Ethical Management Declaration consisted of: ▲ a progress report by the KAIST Special Committee for Ethical Management, ▲ a commemorative address by the president, ▲ an oath of the Code of Ethics and Code of Conduct, and ▲ the presentation of the 'Excellent Ethics Professor Award' organized by the Graduate Student Human Rights Center. Attendees shared the values and meaning of ethical management pursued by KAIST. Particularly at this ceremony, six representatives – faculty, staff, and students – selected to reflect KAIST's values encompassing diversity in position, role, gender, and future generations, took the oath for the Code of Ethics and Code of Conduct. < Photo 2. Attendees pledge to practice ethics during the Ethical Management Declaration. > Also introduced at the ceremony was the "Ethical Excellence Award for Professors". It is an award that was organized by the Graduate Student Human Rights Center under the KAIST Student Council to recognize the faculty members for their outstanding ethical conduct in the laboratory setting. The 2025 recipients of the newly established award were the honored at the declaration ceremony for added significance. Taking this declaration ceremony as an example, KAIST plans to actively encourage each departments, divisions and offices to also hold ethical management declarations of their own to establish a trustworthy, healthy, and transparent organizational culture through the daily practice of ethical responsibilities, and to continuously spread the practice of ethical management among all members. President Kwang Hyung Lee emphasized, "Adhering to research and social ethics must be the foundation for KAIST to become a university trusted globally," and expressed, "I hope this ceremony serves as a turning point for all members to more faithfully practice their ethical responsibilities and duties."

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