Science+and+Technology
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New drug targeting method for microbial pathogens developed using in silico cell
A ripple effect is expected on the new antibacterial discovery using “in silico” cells
Featured as a journal cover paper of Molecular BioSystems
A research team of Distinguished Professor Sang Yup Lee at KAIST recently constructed an in silico cell of a microbial pathogen that is resistant to antibiotics and developed a new drug targeting method that could effectively disrupt the pathogen"s growth using the in silico cell.
Hyun Uk Kim, a graduate research assistant at the Department of Chemical and Biomolecular Engineering, KAIST, conducted this study as a part of his thesis research, and the study was featured as a journal cover paper in the February issue of Molecular BioSystems this year, published by The Royal Society of Chemistry based in Europe.
It was relatively easy to treat infectious microbes using antibiotics in the past. However, the overdose of antibiotics has caused pathogens to increase their resistance to various antibiotics, and it has become more difficult to cure infectious diseases these days.
A representative microbial pathogen is Acinetobacter baumannaii. Originally isolated from soils and water, this microorganism did not have resistance to antibiotics, and hence it was easy to eradicate them if infected. However, within a decade, this miroorganism has transformed into a dreadful super-bacterium resistant to antibiotics and caused many casualties among the U.S. and French soldiers who were injured from the recent Iraqi war and infected with Acinetobacter baumannaii.
Professor Lee’s group constructed an in silico cell of this A. baumannii by computationally collecting, integrating, and analyzing the biological information of the bacterium, scattered over various databases and literatures, in order to study this organism"s genomic features and system-wide metabolic characteristics. Furthermore, they employed this in silico cell for integrative approaches, including several network analysis and analysis of essential reactions and metabolites, to predict drug targets that effectively disrupt the pathogen"s growth. Final drug targets are the ones that selectively kill pathogens without harming human body.
Here, essential reactions refer to enzymatic reactions required for normal metabolic functioning in organisms, while essential metabolites indicate chemical compounds required in the metabolism for proper functioning, and their removal brings about the effect of simultaneously disrupting their associated enzymes that interact with them.
This study attempted to predict highly reliable drug targets by systematically scanning biological components, including metabolic genes, enzymatic reactions, that constitute an in silico cell in a short period of time.
This research achievement is highly regarded as it, for the first time, systematically scanned essential metabolites for the effective drug targets using the concept of systems biology, and paved the way for a new antibacterial discovery. This study is also expected to contribute to elucidating the infectious mechanism caused by pathogens.
"Although tons of genomic information is poured in at this moment, application research that efficiently converts this preliminary information into actually useful information is still lagged behind. In this regard, this study is meaningful in that medically useful information is generated from the genomic information of Acinetobacter baumannii," says Professor Lee. "In particular, development of this organism"s in silico cell allows generation of new knowledge regarding essential genes and enzymatic reactions under specific conditions," he added.
This study was supported by the Korean Systems Biology Project of the Ministry of Education, Science and Technology, and the patent for the development of in silico cells of microbial pathogens and drug targeting methods has been filed.
[Picture 1 Cells in silico]
[Picture 2 A process of generating drug targets without harming human body while effectively disrupting the growth of a pathogen, after predicting metabolites from in silico cells]
2010.04.05 View 14577 -
KAIST Commencement 2010 was held on February 26, 2010.
A total of 2,205 are the newly conferred degree holders: 479 for Ph.D., 988 for Master’s, and 738 for B.S. degrees. Since its foundation in 1971, KAIST has so far produced 38,882 graduates.
KAIST held the 2010 graduation ceremony on February 26, 2010 at its newly built place, called “Sports Complex Building.” Approximately 2,500 guests including Minister Byung-Man Ahn, Education, Science and Technology Ministry; Chairman Mun-Sul Jeong, KAIST Board of Trustees; representatives from the KAIST alumni; graduating students; and faculty joined the ceremony to celebrate the commencement.
Honorary Doctorates
At the ceremony, KAIST has conferred four honorary doctorate degrees in recognition of recipients’ contribution to the advancement of science and technology and development of science and engineering education in Korea and the world. The recipients were Arden L. Bement Jr., Director of US National Science Foundation; Lars Pallesen, President of Technical University of Denmark; Donald C.W. Kim, Chairman of AMKOR A&E, Inc.; and Beang-Ho Kim, Chairman of Seojeon Farm.
Graduation Honors: President’s List
Dong-Han Kim, majoring in Mathematical Sciences, College of Natural Science, was nominated as President’s List. He received an award for an outstanding academic achievement from the Minister of Education, Science and Technology and gave a gradation speech on behalf of the graduating class.
Birthplace of Promising Young Scientists in Korea
KAIST has earned a reputation for training the next generation of young scientists in Korea, and its 2010 Commencement has confirmed such fame. Among 479 Ph.D. degree holders, 151 (31%) students are in their 20s. The youngest who has received a doctoral degree is Jin-Ah Lee, graduating from College of Life Science and Bioengineering.
Commencing International Students
Among international students graduating this year, two students from India received their doctoral degrees in Biological Sciences: Kataru Raghu Prasad and Chaya Mohan. They are a married couple and now both postdoctoral researchers, working at KAIST labs. Wearing academic regalia and standing together to take a picture, the couple said, “We would definitely recommend KAIST to prospective international students because it offers the best education and research facilities comparable to those of any leading universities in the world. With the knowledge and experience acquired from studying at KAIST, we hope to contribute to the development of our country in the future.”
2010.03.04 View 13613
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KAIST Undergraduates Open Four-Day International Conference
The ICISTS-KAIST, an annual international conference organized by KAIST undergraduate students, opened on Thursday (Aug. 20) at the KAIST"s main campus in Daejeon.
The 2009 ICISTS (International Conference for the Integration of Science and Technology into Society) drew around 200 experts and students from 44 countries. Since its inception in 2005 to promote discourse on important science and technology issues affecting modern society, the conference has served as an opportunity for academic networking among students in various parts of the world.
The four-day conference consists of lectures, open discussions among lecturers and students, field trips to help students to understand actual applications, and team projects.
This year"s conference offers three workshops under the themes of "Climate Change: Merging Technology and Policy for Green Solutions"; "Human-Computer Interaction: Designing Computer System for Intuitive Human Access"; and "Nano Clinic: Breakthrough in Conquering Disease."
Lectures by invited experts in various scientific fields will help broaden students" perspectives particularly from interdisciplinary viewpoints, said an organizer of the conference.
2009.08.28 View 13499
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Int'l Conference for Integration of Science & Technology into Society Opens
The 2008 International Conference for the Integration of Science and Technology into Society (ICISTS-KAIST) opened a four-day meeting on Tuesday (July 15) at Daejeon KAIST campus. The conference is an annual event organized by a group of KAIST undergraduate students.
The fifth-year gathering is designed to provide participants with an opportunity to broaden their scientific perspectives by sharing ideas and experiences in related topics, as well as building an international human network. This year"s event has drawn about 200 students from 40 countries.
The centerpiece of the conference is three workshops on the following themes; Human-Robot Symbiotic Society, Neo-brain Science and Trafficmatics. Myung-Ja Kim, former Korean Environment Minister, will appear as a keynote speaker.
In the workshop sessions, two speakers will discuss specific issues and arrive at a tentative conclusion. Participants will have the opportunity to participate in the debate through Q&A for each session.
The first theme "Human-Robot Symbiotic Society" delves into the current trend that robot is being transformed into a perceivable and touchable concept from an abstract one. Guests for the workship include June-Ho Oh, professor at the Department of Mechanical Engineering, KAIST; James Dater, professor at the Department of Political Science, University of Hawaii at Manoa, and Director of the Hawaii Research Center for Future; Michael Pollitt, CEO of Shadow Robot Company; and Steven Dubowsky, professor at the Department of Mechanical Engineering, MIT.
The second theme "Neo-Brain Science" focuses on attempts to shed light on brain from diverse perspectives including psychology, economics and art. Among invited speakers are Prof. Jai-Seung Jung at the Department of Bio and Brain Engineering, KAIST; Prof. Un-Jung Kang at the University of Chicago Medical Center; and Peter Geyer, a consultant for the Association for Psychological Type.
The third workshop on "Traffimatics" will deal with "intelligent transport systems (ITS)" which will discusst new paradigm in transportation policy and traffic engineering. On the list of speakers are Assaf Biderman, assistant director, SENSEable City Laboratory, MIT; Prof. Richard Tay, at the Department of Civil Engineering, University of Calgary; Prof. Shoshi Mizokami at Kumamoto University; and Ho-Jong Baik, research associate professor of Virginia Tech.
2008.07.16 View 17261 -
Super-Fast Internet Data Chip Developed
A KAIST research team led by Prof. Kyoung-Hoon Yang of the Electrical Engineering & Computer Science Department developed a super-fast chip that could lead to huge advancements in broadband Internet technology, the Korean Ministry of Education, Science and Technology said on Thursday (June 26).
The multiplexer chip is the first of its kind to be developed using the quantum effect of resonant tunnelling diode, according to the Ministry.
The integrated circuit chip built at the university laboratory has an operating speed of 45 gigabits per second (Gb/s), while using roughly 75 percent less energy than the previous version. The speed enables the transfer of about 4 full-length movies in one second.
The best operational broadband Internet services provide users with data transfer speed of 40 Gb/s, while most other high-speed online connections offer 10 Gb/s.
"Besides speed, the greatest achievement is low energy use," Prof. Yang said. He stressed that energy use in chips is a crucial factor because power creates heat that can melt circuits and make them inoperable.
"By cutting down on energy use, the new chips can be made smaller and with faster data transfer speed," the scientist said.
He added that efforts are underway to increase operational speed to 100 Gb/s, with energy consumption to be cut to 10 percent of current chips like the high electron mobility transistor, the heterojunction bipolar transistor and the complementary metal oxide semiconductor.
The researcher speculated that such revolutionary chips could be developed in 1-2 years and become the new benchmark in this field since existing chips have limited development capabilities.
The project has received funding from the Education-Science-Technology Ministry since 2000. The Ministry"s financial support will last until 2010.
2008.06.26 View 12101 -
KAIST, ICU Agree to Merge
KAIST and the Information and Communications University, a state-run institution, decided to merge as they signed a memorandum of understanding for unification at the Westin Chosun Hotel in Seoul on May 23.
The MOU signing ceremony was attended by representatives of the two universities and related high-ranking government officials from the Ministry of Knowledge Economy and the Ministry of Education, Science and Technology.
Under the agreement, the two universities will form a joint committee to complete the merger process by the end of this year. According to the MOU, ICU will become the "IT Convergence Campus" (ICC) which will include KAIST"s IT related departments and research institutes. The projected ICC will be headed by a KAIST vice president, KAIST authorities said.
With the merger, the number of KAIST students in the IT area will increase to 2,850 from 1,951, while the number of IT-related faculty members will rise to 157 from 99.
ICU was established in 1997 by the Korean Ministry of Information and Communication, the Electronics and Telecommunications Research Institute, and some major Korean IT companies. Located in Daedeok Science Town in Daejeon where KAIST is also situated, ICU started as a graduate school and added the undergraduate course in 2002. It currently has a total enrollment of 1,121 students -- 481undergraduate students, 324 graduate students and 316 doctorate students.
KAIST said that it will treat ICU professors and staff equally after the merger. This year, the two universities will separately conduct freshmen recruitment procedures for 2009, but will then unify recruitment.
The unification of the two institutions is expected to give KAIST the competitive edge through a larger faculty, student body, and expanded facilities.
The agreement put an end to extended negotiations for merger which started in July 2006. The talk of merging the two universities surfaced when the Board of Audit and Inspection concluded that the government"s direct financial support for ICU was unlawful as ICU was established as a private school. When ICU was established in 1997, the Ministry of Information and Communication provided 200 billion won as the basic endowment and has continually provided 10 billion won in operating funds each year.
2008.05.22 View 13363
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KAIST Takes Merging Steps with ICU
Plans to begin the merging of Korea Advanced Institute of Science and Technology (KAIST) and Information and Communications University (ICU) have emerged.
ICU board members and Ministry of Information and Communications (MIC) officials held a meeting at Lotte Hotel, Seoul, on November 21st. The two parties agreed upon the merging of KAIST and ICU; and an interim organization to carry out the merging procedures was to be established. In addition, a preliminary road-map was presented during the meeting.
In the event that a company would show a willingness to financially support ICU, the parties agreed to take this path into consideration as well.
Also at this meeting, the resignation of ICU President Huh Unna was accepted by the board members of ICU. President Huh and the executive board have opposed any proposals of unification between the two universities. The president called for an independent ICU in response to MIC’s withdrawal of funding.
On November 27th, ICU Electrical Engineering Professor Hyuck Jae Lee was appointed as ICU president.
The talk of merging the two universities surfaced when the Board of Audit and Inspection concluded that financial support of ICU from the government was illegal as ICU was established under the private school law exempting the institution from governmental support. When ICU was established in 1997, MIC provided 200 billion Korean Won and has continually supported the university financially with 10 billion Korean Won per year.
Both universities have not released official statements regarding the merging of the respective institutions.
ICU has a student body of about 400 undergraduate students and 600 graduate students. On the other hand, KAIST has a student body of around 3000 undergraduate students, 2000 graduate students, and 2000 doctorate students. Both institutions are located in Daejeon, Korea.
Talk of establishing a single-department IT-convergence university where ICU is currently located surfaced as a possible merging-concept by KAIST.
Organizations and groups opposing the unification of the two technology-related institutions are concerned with details of the merger, such as the personnel management of ICU professors. However, analyses demonstrate that the unification will give KAIST the competitive edge through a larger faculty, student body, and increased facilities.
In July, an in-house poll was conducted at ICU and the results showed that 15 percent of graduate school students and undergraduate students were against the merger while 82.6 percent of undergraduate students and 84.8 percent of graduate students were in favor. 88.6 percent of ICU professors supported the unification of the two universities.By KAIST Herald on December, 2007
2007.12.21 View 12175
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S&T Policy Agenda of Major Presidential Candidates
Science and Technology Policy Agenda of Major Presidential Candidates
The KAIST TIMES recently reviewed science and technology policy suggestions made by five major presidential candidates. Below is a summary of the information assembled based on written interviews conducted by The KAIST TIMES, gatherings on science and technology policies, and press conferences.
Chung Dong-young of the United New Democratic Party
The UNDP’s Chung Dong-young presented a vision to join the world’s top seven aerospace leaders in an effort to transform Korea into a science-technology powerhouse.
In order to achieve this goal, he suggested five policy strategies: support research and development of creative, innovative science and technology, ; expand resources for the innovation of science and technology, ; promote academia and business partnerships, ; strengthen infrastructure to innovate scientific and technological fields, ; boost the morale of scientists and engineers, ; and promote the dissemination of scientific culture.
The most noticeable striking part element of his vision is to make add Korea to join the list of the world’s top seven aerospace powerhouses. Chung included the this vision in his 20 key 20 pledges, underscoring his commitment to the aerospace industry. He said that the aerospace industry can produce simultaneous growth of various high-tech industries.
Chung also vowed that he would extensively foster high-value added assembly industry in conjunction with a scheme to nurture parts and material industries.
As detailed action plans to achieve his vision, he cited development of small and medium-sized aircraft carriers and upgrading air control systems as part of the efforts to make Korea as a stronghold of popular aviation of in Northeast Asia. He also revealed plans to embark on a project to explore the Moon and send an unmanned probe there by 2020.
To implement aerospace development plans systematically, he suggested inaugurating the envisioned Korean Aeronautics and Space Administration, modeled after the NASA of the United States and JAXA of Japan.
Lee Myung-bak of the National Grand Party
Presidential candidate Lee pointed out basic sciences and open-source technologies as crucial prerequisites to achieve economic growth. As five implementation strategies to promote the development of these areas, he called for the fostering of more scientific and technological talents; a drastic increase in investment in science and technology; creation of new fusion industries that will serve as future growth engines; promotion of autonomy and creativity; and popularization of science and technology.
He also pledged to carry out two large-scale projects, the creation of “an international scientific-corporate city belt” and the technological development of new renewable energy.
Among them, drawing the largest attention is the creation of an “international scientific-corporate city belt” connecting several technological complexes located in Chungcheong Provinces. The city belt is envisioned to connect the Daedok Innopolis in Daejeon, the proposed Bio-Health Science Technopolis in Osong, Sceintific Industrial Complex in Ochang, and the new administrative town under construction in Yeongi-Gongju. At a lecture hosted by the Science and Technology Forum and the Korean Engineers Club, Lee said that the project has been motivated by the idea of locating research and corporate complexes in close proximity to bring about maximum efficiency of commercializing research results.
Kwon Young-ghil of the Democratic Labor Party
In a written interview with The KAIST TIMES, Kwon summed up his vision for science and technology as shifting from “science-technology for the rich and privileged” to “science and technology to promote public interest and participation.”
As action plans to realize his vision, he suggested increasing investment into public-interest research and development projects and building the necessary infrastructure as well as boosting relevance between science-technology policies and various welfare sectors including environment, health, and medicare. He also wishes to pay greater attention to improving the treatment of young engineers and scientists.
Moon Kook-hyun of the Creative Korea Party
Moon Kook-hyun’s science and technology policy proposals focus on nurturing more experts in the fields of science and technology. As specific action plans to ease the tendency among high-school graduates to shun the fields engineering and science as their majors, he revealed a plan to appoint a Prime Minister with an engineering or scientific background and positively expand social participation of engineering or science graduates.
He also expressed strong commitment to making Korea a technological power house, focusing on convergence of various high-tech industries including BT and IT. He would also build infrastructure to increase cooperation for technological development among large and mid and small-sized companies, and among Korea and many other countries.
Independent Candidate Lee Hoi-chang
Lee Hoi-chang’s vision for science and technology can be highlighted by his strong commitment to greatly increasing R& D investment in this area. He said that the move is aimed at expanding science and technology capital, which will serve as a fundamental infrastructure for corporate activities.
In particular, he said that he would concentrate on fostering eight core technologies based on individual knowledge and creativity: IT, BT, NT, ST, ET (Environment Technology), CT, MT(Marine Technology), and FT (Fusion Technology).
2007.12.17 View 15283
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Dual Degree Programs with TU Berlin
Dual Degree Programs with TU Berlin- Five students to be exchanged each year from this year, receive degrees from both schools- Final stage of negotiation with GIT, UCSB- On-going DDP negotiations with Delft University of Technology in Netherlands, Royal Institute of Technology in Sweden, Technical University of Denmark, Norwegian University of Science and Technology, Tsinghua University in China, Tokyo Institute of Technology- DDPs with Ecole Polytechnique, INSA Lyon of France, and University of Karlsruhe of Germany underway at department levels
KAIST (President Nam-Pyo Suh) will begin Dual Degree Programs (DDP) with Technical University of Berlin (TU Berlin).
The both recently reached an accord on the implementation of DDP and will exchange maximum five students each year, starting this year. The DDP allows each school involved to exchange students who meet the counterpart’s requirements one-by-one with prior consensus of departments to accept the students and to confer its own diplomas on students who complete the prescribed graduation requirements.
TU Berlin, established in 1770, currently holds 28,344 enrolled students, among which 5,829 students are from abroad (over 20%) and provides lectures for more than 50 subjects in the fields of Humanities, Social Sciences, Economics and so on with its emphases on Natural Science and Engineering. TU Berlin has fostered a multitude of distinguished scientists, including 1986 Nobel Prize Recipient in Physics Ernst Ruska who developed an electronic microscope for the first time in the world.
KAIST has now been eagerly promoting the DDPs with many distinguished foreign universities. It is on the final stage of the DDP negotiation with Georgia Institute of Technology (GIT) and University of California Santa Barbara (UCSB), and has already agreed with Tsinghua University in China to implement the DDPs in several advanced fields. Also, an agreement with Tokyo Institute of Technology (TIT) is soon to be made.
With Ecole Polytechnique and INSA Lyon of France, and University of Karlsruhe of Germany, the negotiation is underway at department levels, and the DDPs are also being promoted with Milan Technical University of Italy, Delft University of Technology of Netherlands, Royal Institute of Technology (KTH) of Sweden, Technical University of Denmark (DTU), Norwegian University of Science and Technology (NUNT).
“As global interests in East Asia arise, interests in KAIST by many foreign universities also increase. We are planning to expand the scope of this program to provide KAIST students with more opportunities of studying abroad and to attract more outstanding foreign students,” KAIST Dean of Academic Affairs Kwang-Hyung Lee explained.
- Dual Degree Program (DDP)In DDP, schools involved can maintain their own curriculums and confer their own degrees on students who complete the graduation requirements. Therefore, students can receive degrees from both schools involved. Meanwhile, DDP is not the same concept with Joint Degree Program (JDP), in which schools involved establish a joint curriculum and confer a single joint degree on students.
2007.03.19 View 17907
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Professor Jongwon Lee wins Korean Engineering Award
Professor Jongwon Lee wins Korean Engineering Award
Professor Jongwon Lee of the department of Mechanical Engineering won the 7th Korean Engineering Award conferred by the Ministry of Science and Technology and Korean Science and Engineering Foundation.
Professor Lee is a world-famous scholar in the field of ‘dynamics and vibration of rotors’ and his work in 1993, ‘Vibration Analysis of Rotors’, is highly recognized as a creative and practical research on the dynamics of rotors.
The Korean Engineering Award is conferred on domestic scientists who have made world-level research achievements in the engineering field by the Ministry of Science and Technology and Korean Science and Technology Foundation every two years.
2007.01.11 View 12142
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KAIST hosts Korea-China High-tech Expo
KAIST hosts Korea-China High-tech Expo
- Three days from Tuesday, December 12 at Beijing International Convention Center in China
- 30 Korean companies and 40 Chinese companies will participate and exhibit cutting-edge technologies
KAIST (President Nam-Pyo Suh) will host ‘Korea-China High-Tech EXPO 2006’ with Chinese Association for Science and Technology (CAST) at Beijing International Convention Center in China for three days from Tuesday, December 12.
‘Korea-China High-Tech EXPO’ is an event which has taken place annually since the conclusion of the Memorandum Of Understanding (MOU) for the enhancement of international joint researches and mutual exchanges between KAIST and Tsinghua University in the year of 2002 and faces the 4th time this year.
The event began for the activation of technical exchanges between top venture enterprises of the both countries and the enhancement of academic exchanges between top technical universities of the both countries and now has grown into a business stage for the enhancement of competitiveness of venture enterprises and the creation of new markets.
In the event, 30 companies, including Golfzon Co,. Ltd. etc., and 4 institutes, including KAIST Human-Friendly Welfare Robot System Engineering Research Center, etc., from Korea and 40 companies from China will participate and exhibit their cutting-edge technologies. The participants have been selected with the focus on technologies requested by China-side, and each participant will be provided with opportunities of detailed consultation with buyers from ten companies of China. During the event, subsidiary events like excellent technology exhibition, Korea-China technical business forum, special introductions of goods by Mosin Biotech, Inc. and Daeduk Lab Inc., etc. will take place.
2006.12.11 View 13956
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Retirement of Professor Jung-Woong Ra
Retirement of Professor Jung-Woong Ra
The first professor of KAIST Electrical Engineering and Computer Science Department Jung-Woon Ra, who is also the former president of Gwangju Institute of Science and Technology (GIST), retired.
Professor Ra joined KAIST as professor in 1971, the year of KAIST foundation, and established the Department of Electrical Engineering and Computer Science. He has significantly contributed to the development of the department and is recognized for his sincere devotion to the rapid growth of GIST into a specialized research-oriented university as the head of GIST Foundation Committee and the third president of GIST.
For the past 35 years in KAIST, Professor Ra has educated 37 Ph.Ds and 90 masters, and presented 113 papers in domestic and world renowned journals and 93 academic papers.
Particularly, Professor Ra, world-class scholar in the field of electromagnetic wave utilization and application, invented ‘successive electromagnetic wave ground penetrating radar’, with which he discovered the fourth tunnel made by North Korean Military Forces in 1989.
In recognition of his contribution to manpower education and development of science and technology, he won Moran medal of Order of Civil Merit in 1999 and was awarded as a man of merit for electromagnetic wave development in 2005.
Retirement ceremony for Professor Jung was held at Dream Hall in ChungMoonSoul building last Friday, September 29, and Professor Jung was named as Emeritus Professor at the ceremony.
2006.10.10 View 14925