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KAIST Industrial Design’s Professor Sangmin Bae’s team selected as Top 20 of James Dyson Award 2024
KAIST (President Kwang-Hyung Lee) announced that the 'Oxynizer', a non-electrical medical oxygen generator for developing countries designed by Professor Sangmin Bae's team in the Department of Industrial Design, has been selected to be the Top 20 of the James Dyson Award 2024. At the same time, it was announced on the 16th that it was selected as one of the top 100 ‘Prototypes for Humanity’ 2024 and will be exhibited in Dubai in November.
< Photo 1. Photo of the award-winning team of Professor Sangmin Bae’s students of KAIST Department of Industrial Designs at the James Dyson Award 2024 announcement of the National Winners >
The James Dyson Award is a design award hosted by Sir James Dyson, founder of Dyson, and receives ideas for solving everyday problems from next-generation engineers and designers around the world, and selects and awards innovative and excellent designs every year.
The ‘Oxynizer’ developed by Professor Sangmin Bae’s team was selected as the winner of the screening within Korea in September after competing with 122 domestic teams, and was awarded a prize of 5,000 pounds for idea advancement, product development, and commercialization.
< Photo 2. A photo of Professor Sangmin Bae’s students’ award-winning achievement, ‘Oxynizer’ >
In addition, on October 16th, it was selected as one of the top 20 international winners among 1,911 competing works from 29 countries around the world. The international winner will be selected by Sir James Dyson and announced on November 13th. The international competition winner will receive a prize of £5,000, and the winner will receive an additional £30,000, giving them the opportunity to commercialize their idea.
‘Prototype for Humanity’ is a global project hosted by Art Dubai Group and carried out in collaboration with Dubai Future Foundation, Dubai Arts & Culture Authority, and Dubai International Financial Center. It is a forum for international cooperation where leading universities around the world, including Harvard University and MIT, participate to discuss global problems and solutions.
‘Oxynizer’ was selected on September 11 as one of the top 100 out of 3,000 entries submitted by universities in over 100 countries, and will be exhibited at the Jumeirah Emirates Towers of Dubai Future Foundation from November 17 to 22. The organizers will select the top five during the exhibition period, and will award a total of $100,000 in prize money to the winners to support their research.
The ‘Oxynizer’ is a device developed by students Jiwon Kim, Kyeongho Park, Seung-Jun Lee, Jiwon Lee, Yeohyeon Jeong, and Jungwoo Kim under the guidance of Professor Sangmin Bae of KAIST, and is the result of research conducted in the ‘Design Project 1’ class for the graduate students of the Department of Industrial Design at KAIST.
< Photo 3. A photo of Professor Sangmin Bae’s students’ award-winning achievement, ‘Oxynizer’ >
This device was designed to solve the problem of difficulty in supplying oxygen in developing countries due to high installation and maintenance costs. The device was designed to create concentrated oxygen to supply it to a patient in urgent need using an air pump for bicycles, which should be found more easily than a medical oxygen tank.
Professor Sangmin Bae said, “This device creates oxygen using a bicycle air pump and supplies it to patients, and it can separate water vapor and nitrogen in the air using silica gel and zeolite, which are the main materials of the filter, to supply oxygen with a concentration of up to 50%.” “In addition, the filter can be heated and reused after 120 hours of use, so it has the advantage of being able to be used semi-permanently,” he emphasized.
< Photo 4. A photo of Professor Sangmin Bae’s students’ award-winning achievement, ‘Oxynizer’ >
The results of the self-research derived from the KAIST Industrial Design Department class were selected as a world-class award winner and exhibition piece in competition with excellent universities around the world, once again proving the global competitiveness of the KAIST Industrial Design Department.
2024.10.16 View 987 -
KAIST President Kwang-Hyung Lee receives honorary doctorate from Université de Montréal
KAIST (President Kwang-Hyung Lee) announced on June 16th that President Kwang-Hyung Lee received an honorary doctorate on the 15th, local time, from the Université de Montréal in Canada, one of the largest French-speaking universities in North America.
< Image. (from left) Mr. Pierre Lassonde, Chairman of the Board of Polytechnique Montréal, President Maud Cohen of Polytechnique Montréal, President Kwang-Hyung Lee of KAIST, Chancellor Frantz Saintellemy of Université de Montréal and Mr. Alexandre Chabot, Secretary General of Université de Montéal. >
President Lee was selected as the recipient of the honorary doctorate from the Université de Montréal upon the recommendation of Polytechnique Montréal in recognition of his contributions in pioneering the multidisciplinary approach to integrate a number of fields studies including computer science, biology, and nanotechnology.
Polytechnique Montréal is a university in affiliation with the University of Montréal and is one of the largest engineering education and research institutions of Canada. President Lee's honorary doctorate was awarded at the Convocation Ceremony of Polytechnique Montréal held for the Class of 2024. On this day, Mr. Serge Gendron, a businessman, a philanthropist and an alum of Polytechnique Montréal, also had the honor of receiving an honorary doctorate along with President Lee.
President Kwang-Hyung Lee is internationally recognized for his contributions in various fields, including engineering education, multidisciplinary research, strategy establishment, and future prospects. President Lee is also well known to have had significant influence on the first-generation venture entrepreneurs, a large portion of which are from KAIST, who have now grown into full-fledged entrepreneurs. For these activities, President Lee received numerous decorations and commendations within Korea, including the National Order of Civil Merit - Camellia Medal, and in 2003, he received the ‘Légion d’Honneur Chevalier’ from the French government as well.
Through his speech at the ceremony, KAIST President Kwang-Hyung Lee expressed his gratitude to the Université de Montréal and Polytechnique Montréal, while congratulating and encouraging the graduates who are poised to start anew as they part from the school. “Hold on to your dreams, try looking at the world from a different perspective, and enjoy the challenges without being afraid of failures.” With these three pieces of advice, President Lee cheered on the graduates saying, “The future belongs to those of you who challenge them.”
Maud Cohen, the President of Polytechnique Montréal, commented on President Kwang-Hyung Lee's honorary doctorate, that Polytechnique Montréal is proud to award an honorary doctorate to Mr. Lee for his exceptional career path, his holistic, multidisciplinary and undeniably forward-looking vision, which strongly echoes the values of Polytechnique Montréal, and for his involvement in and commitment to education, research and the future of the next generation.
* Established in 1873, Polytechnique Montréal is one of Canada’s largest engineering education and research universities, and is located on the Université de Montréal campus – North America’s largest Francophone university campus. Joshua Bengio, who won the Turing Award for establishing the foundations of deep learning, is gaining international recognition in artificial intelligence and other related fields at Polytechnique Montréal. Polytechnique Montréal chose KAIST as the first Korean university establish partnership with and has continued to build up close cooperative relationship since 1998.
* The Université de Montréal (UdeM) is a public university founded in 1878. It is located in Montréal, in the French-speaking province of Québec, Canada. It is one of Canada's five major universities, and the second largest in terms of student enrollment. The Université de Montréal is the largest in the French-speaking world in terms of both student enrollment and research. The Université de Montréal enjoys an excellent reputation as one of the best French-language post-secondary institutions. Its rector is Mr. Daniel Jutras.
2024.06.16 View 2961 -
World-renowned Soprano Sumi Jo and Broadcom CEO Hock Tan awarded honorary doctorate from KAIST
< (From left) Sumi Jo, Distinguished Visiting Professor at the Graduate School of Culture and Technology, and Broadcom President and CEO Hock Tan >
KAIST (President Kwang-Hyung Lee) announced that it awarded honorary doctorates to world-renowned soprano Sumi Jo, a distinguished visiting professor at the Graduate School of Culture and Technology, and the President and Chief Executive Officer of Broadcom Inc., Hock Tan, at the graduation ceremony held on the 16th of February, 2024.
Professor Sumi Jo, who received an honorary doctorate in science and technology, was appointed as a visiting professor at KAIST Graduate School of Culture and Technology in 2021 and established the "Sumi Jo Performing Arts Research Center" and have been involved in research providing valuable feedback on projects to put on stage performances utilizing AI-orchestrated musical ensemble technology and research on virtual voices using vocal synthesis technology, as well as participating in the demonstration of the technological performance showcased at KAIST. Also, she held a special lecture and a talk concert for KAIST students, sharing her experience as a celebrated soprano on the world stage and having honest conversations with students.
KAIST said, “The doctorate is being awarded in recognition of her contributions that is broadening the spectrum of research in the field of science and technology to lead the digital era by suggesting a direction for future
science and technology to take led by culture. Also, her significant contribution to promoting necessary internationalization capabilities helps KAIST as it is growing into a world-class university through new academic challenges.”
< Professor Sumi Jo (left), who received an honorary doctorate in science and technology, and President Kwang-Hyung Lee >
Professor Sumi Jo, who debuted as Gilda in the opera in 1986, has performed with world-class conductors such as Herbert von Karajan, Georg Solti, Zubin Mehta, and James Levine. She has released over 40 full-length albums and continues to excel in all areas of vocal performances, including film scores, songs, and musicals.
Professor Sumi Jo said, “When I received a proposal from President Kwang-Hyung Lee of KAIST to convey what I experienced and felt on the world stage to students of science at KAIST under the topic of ‘Music and My Life,’ questions started to swirl inside of me.”
She continued, “Singing on stage is about ‘expressing,’ and it is a comprehensive artistic process that unfolding the artist’s inner self (expression) and showing it (presentation) in a way that the audience can best feel it through
methods such as sound, lighting, and directing. And I realized that, I was singing all my life in an environment where science and technology coexisted with culture and art.”
“When I worked with the students here at KAIST, I came to realize that when scientific and technologically talented people are set free to really enjoy their ideas and explore them on their own terms, their insight become sharper and their creativity become richer,” she said. She went on to add, “I am proud to be able to join the graduates at the ceremony and would like to express my gratitude for awarding me the honorary doctorate.”
< (From left) President Hock Tan, who received the honorary doctorate in engineering, Mrs. Lya Trung Tan, and President Kwang-Hyung Lee >
Hock Tan received an honorary doctorate in engineering. He is a highly successful businessman who demonstrated entrepreneurship based on a profound understanding of science and technology, which transformed Broadcom into a global enterprise in technology that provides semiconductor and software solutions.
Broadcom has achieved advancement and technological innovation in the semiconductor industry tailored to computer and telecommunication networks, and is evaluated as having played a major role in bringing about the digital transformation movement that is now encompassing the global communities.
Tan attributes the secret to his success to ‘the considerate decision made by the university to award him the scholarship which enabled him to pursue his degree’ and ‘the great team members working with him’..’ Also, he is well-known as a person who considers giving back to society his most important mission.
To support effective medical treatment and identification of the cause of autism, Tan has made large donations to MIT and Harvard University since 2017 several times, and during the COVID-19 pandemic, he reinforced his support to improve the treatment of workers at community medical institutions and non-profit organizations. He also founded the Broadcom Foundation, which supports science, technology, engineering, and mathematics (STEM) education programs for students in and outside the United States.
KAIST said, “We are awarding CEO Hock Tan the honorary doctorate in recognition of his contribution to KAIST’s emergence as a world-class university, as he emphasized the importance of convergence research and
internationalization of KAIST during his time serving as an overseas member of the KAIST President's Advisory Council from 2006 to 2013, while providing policy advices built on his experiences of innovations from various parts around the world.”
Tan emphasized, “KAIST has been vital to Korea’s advancement in the global economy. (KAIST) remains a source of technological innovation,” and that, “It is truly an honor to be recognized by an institution with such a distinguished record of excellence in science, engineering and research.”
President Kwang-Hyung Lee said, “Professor Sumi Jo’s exploration into the future of performing arts through science and technology helps to expand KAIST’s scope and enhance our creative capabilities, while the dedication and humane efforts Hock Tan demonstrates as he contributes to digital innovation through corporate management and engages in various social contribution activities serves as a superb example to all members of KAIST.”
He continued, “These two have lived out the values of challenge and innovation and became examples for many, and we are very pleased to welcome them as the newest members of the KAIST family. On behalf of all members of KAIST, I deliver our sincere congratulations.”
2024.02.17 View 6541 -
Team KAIST placed among top two at MBZIRC Maritime Grand Challenge
Representing Korean Robotics at Sea: KAIST’s 26-month strife rewarded
Team KAIST placed among top two at MBZIRC Maritime Grand Challenge
- Team KAIST, composed of students from the labs of Professor Jinwhan Kim of the Department of Mechanical Engineering and Professor Hyunchul Shim of the School of Electrical and Engineering, came through the challenge as the first runner-up winning the prize money totaling up to $650,000 (KRW 860 million).
- Successfully led the autonomous collaboration of unmanned aerial and maritime vehicles using cutting-edge robotics and AI technology through to the final round of the competition held in Abu Dhabi from January 10 to February 6, 2024.
KAIST (President Kwang-Hyung Lee), reported on the 8th that Team KAIST, led by students from the labs of Professor Jinwhan Kim of the Department of Mechanical Engineering and Professor Hyunchul Shim of the School of Electrical Engineering, with Pablo Aviation as a partner, won a total prize money of $650,000 (KRW 860 million) at the Maritime Grand Challenge by the Mohamed Bin Zayed International Robotics Challenge (MBZIRC), finishing first runner-up.
This competition, which is the largest ever robotics competition held over water, is sponsored by the government of the United Arab Emirates and organized by ASPIRE, an organization under the Abu Dhabi Ministry of Science, with a total prize money of $3 million.
In the competition, which started at the end of 2021, 52 teams from around the world participated and five teams were selected to go on to the finals in February 2023 after going through the first and second stages of screening. The final round was held from January 10 to February 6, 2024, using actual unmanned ships and drones in a secluded sea area of 10 km2 off the coast of Abu Dhabi, the capital of the United Arab Emirates. A total of 18 KAIST students and Professor Jinwhan Kim and Professor Hyunchul Shim took part in this competition at the location at Abu Dhabi.
Team KAIST will receive $500,000 in prize money for taking second place in the final, and the team’s prize money totals up to $650,000 including $150,000 that was as special midterm award for finalists.
The final mission scenario is to find the target vessel on the run carrying illegal cargoes among many ships moving within the GPS-disabled marine surface, and inspect the deck for two different types of stolen cargo to recover them using the aerial vehicle to bring the small cargo and the robot manipulator topped on an unmanned ship to retrieve the larger one. The true aim of the mission is to complete it through autonomous collaboration of the unmanned ship and the aerial vehicle without human intervention throughout the entire mission process. In particular, since GPS cannot be used in this competition due to regulations, Professor Jinwhan Kim's research team developed autonomous operation techniques for unmanned ships, including searching and navigating methods using maritime radar, and Professor Hyunchul Shim's research team developed video-based navigation and a technology to combine a small autonomous robot with a drone.
The final mission is to retrieve cargo on board a ship fleeing at sea through autonomous collaboration between unmanned ships and unmanned aerial vehicles without human intervention. The overall mission consists the first stage of conducting the inspection to find the target ship among several ships moving at sea and the second stage of conducting the intervention mission to retrieve the cargoes on the deck of the ship. Each team was given a total of three opportunities, and the team that completed the highest-level mission in the shortest time during the three attempts received the highest score.
In the first attempt, KAIST was the only team to succeed in the first stage search mission, but the competition began in earnest as the Croatian team also completed the first stage mission in the second attempt. As the competition schedule was delayed due to strong winds and high waves that continued for several days, the organizers decided to hold the finals with the three teams, including the Team KAIST and the team from Croatia’s the University of Zagreb, which completed the first stage of the mission, and Team Fly-Eagle, a team of researcher from China and UAE that partially completed the first stage. The three teams were given the chance to proceed to the finals and try for the third attempt, and in the final competition, the Croatian team won, KAIST took the second place, and the combined team of UAE-China combined team took the third place. The final prize to be given for the winning team is set at $2 million with $500,000 for the runner-up team, and $250,000 for the third-place.
Professor Jinwhan Kim of the Department of Mechanical Engineering, who served as the advisor for Team KAIST, said, “I would like to express my gratitude and congratulations to the students who put in a huge academic and physical efforts in preparing for the competition over the past two years. I feel rewarded because, regardless of the results, every bit of efforts put into this up to this point will become the base of their confidence and a valuable asset in their growth into a great researcher.” Sol Han, a doctoral student in mechanical engineering who served as the team leader, said, “I am disappointed of how narrowly we missed out on winning at the end, but I am satisfied with the significance of the output we’ve got and I am grateful to the team members who worked hard together for that.”
HD Hyundai, Rainbow Robotics, Avikus, and FIMS also participated as sponsors for Team KAIST's campaign.
2024.02.09 View 6405 -
A biohybrid system to extract 20 times more bioplastic from CO2 developed by KAIST researchers
As the issues surrounding global climate change intensify, more attention and determined efforts are required to re-grasp the issue as a state of “crisis” and respond to it properly. Among the various methods of recycling CO2, the electrochemical CO2 conversion technology is a technology that can convert CO2 into useful chemical substances using electrical energy. Since it is easy to operate facilities and can use the electricity from renewable sources like the solar cells or the wind power, it has received a lot of attention as an eco-friendly technology can contribute to reducing greenhouse gases and achieve carbon neutrality.
KAIST (President Kwang Hyung Lee) announced on the 30th that the joint research team led by Professor Hyunjoo Lee and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering succeeded in developing a technology that produces bioplastics from CO2 with high efficiency by developing a hybrid system that interlinked the electrochemical CO2 conversion and microbial bio conversion methods together. The results of the research, which showed the world's highest productivity by more than 20 times compared to similar systems, were published online on March 27th in the "Proceedings of the National Academy of Sciences (PNAS)".
※ Paper title: Biohybrid CO2 electrolysis for the direct synthesis of polyesters from CO2
※ Author information: Jinkyu Lim (currently at Stanford Linear Accelerator Center, co-first author), So Young Choi (KAIST, co-first author), Jae Won Lee (KAIST, co-first author), Hyunjoo Lee (KAIST, corresponding author), Sang Yup Lee (KAIST, corresponding author)
For the efficient conversion of CO2, high-efficiency electrode catalysts and systems are actively being developed. As conversion products, only compounds containing one or up to three carbon atoms are produced on a limited basis. Compounds of one carbon, such as CO, formic acid, and ethylene, are produced with relatively high efficiency. Liquid compounds of several carbons, such as ethanol, acetic acid, and propanol, can also be produced by these systems, but due to the nature of the chemical reaction that requires more electrons, there are limitations involving the conversion efficiency and the product selection.
Accordingly, a joint research team led by Professor Hyunjoo Lee and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST developed a technology to produce bioplastics from CO2 by linking electrochemical conversion technology with bioconversion method that uses microorganisms.
This electrochemical-bio hybrid system is in the form of having an electrolyzer, in which electrochemical conversion reactions occur, connected to a fermenter, in which microorganisms are cultured. When CO2 is converted to formic acid in the electrolyzer, and it is fed into the fermenter in which the microbes like the Cupriavidus necator, in this case, consumes the carbon source to produce polyhydroxyalkanoate (PHA), a microbial-derived bioplastic.
According to the research results of the existing hybrid concepts, there was a disadvantage of having low productivity or stopping at a non-continuous process due to problems of low efficiency of the electrolysis and irregular results arising from the culturing conditions of the microbes.
In order to overcome these problems, the joint research team made formic acid with a gas diffusion electrode using gaseous CO2. In addition, the team developed a 'physiologically compatible catholyte' that can be used as a culture medium for microorganisms as well as an electrolyte that allows the electrolysis to occur sufficiently without inhibiting the growth of microorganisms, without having to have a additional separation and purification process, which allowed the acide to be supplied directly to microorganisms.
Through this, the electrolyte solution containing formic acid made from CO2 enters the fermentation tank, is used for microbial culture, and enters the electrolyzer to be circulated, maximizing the utilization of the electrolyte solution and remaining formic acid. In addition, a filter was installed to ensure that only the electrolyte solution with any and all microorganisms that can affect the electrosis filtered out is supplied back to the electrolyzer, and that the microorganisms exist only in the fermenter, designing the two system to work well together with utmost efficiency.
Through the developed hybrid system, the produced bioplastic, poly-3-hydroxybutyrate (PHB), of up to 83% of the cell dry weight was produced from CO2, which produced 1.38g of PHB from a 4 cm2 electrode, which is the world's first gram(g) level production and is more than 20 times more productive than previous research. In addition, the hybrid system is expected to be applied to various industrial processes in the future as it shows promises of the continuous culture system.
The corresponding authors, Professor Hyunjoo Lee and Distinguished Professor Sang Yup Lee noted that “The results of this research are technologies that can be applied to the production of various chemical substances as well as bioplastics, and are expected to be used as key parts needed in achieving carbon neutrality in the future.”
This research was received and performed with the supports from the CO2 Reduction Catalyst and Energy Device Technology Development Project, the Heterogeneous Atomic Catalyst Control Project, and the Next-generation Biorefinery Source Technology Development Project to lead the Biochemical Industry of the Oil-replacement Eco-friendly Chemical Technology Development Program by the Ministry of Science and ICT.
Figure 1. Schematic diagram and photo of the biohybrid CO2 electrolysis system.
(A) A conceptual scheme and (B) a photograph of the biohybrid CO2 electrolysis system. (C) A detailed scheme of reaction inside the system. Gaseous CO2 was converted to formate in the electrolyzer, and the formate was converted to PHB by the cells in the fermenter. The catholyte was developed so that it is compatible with both CO2 electrolysis and fermentation and was continuously circulated.
2023.03.30 View 6555 -
KAIST confers Honorary Doctorate of Science on NYU President Emeritus John Edward Sexton
< Photo 1. NYU President Emeritus John Edward Sexton posing with KAIST President Kwang Hyung Lee holding the Honorary Doctorate at the KAIST Commencement Ceremony >
KAIST (President Kwang Hyung Lee) announced that it conferred an honorary doctorate of science degree on NYU President Emeritus John Edward Sexton at the Commencement Ceremony held on the 17th.
An official from KAIST explained, "KAIST is conferring an honorary doctorate for President Sexton's longstanding leadership in higher education, and for his contributions to the process of establishing the groundwork for collaboration with NYU through which KAIST is to become a leading global value-creating university."
President Emeritus Sexton served as the president of NYU from 2002 to 2015, establishing two degree-granting campuses and several global academic sites of NYU around the world. Because of its steady rise in university rankings, such as its medical school earning the number two position in the United States, not only has NYU joined the ranks of first-class universities, but it has also achieved remarkable growth, with the number of students increasing dramatically from 29,000 to 60,000.
In addition, during his tenure as president at NYU, President Emeritus Sexton successfully expanded fundraising to support the University’s academic goals. During his 14-year tenure as president, he organized initiatives such as 'Raise $1 Million Every Day' and 'Call to Action' to raise $4.9 billion in donations, the largest in NYU history to date.
President Emeritus Sexton is famous for teaching full time even during his presidential tenure and for the anecdotes about his special care for students, addressing the school members as “family”. In particular, he is famous for giving hugs to all graduates at the commencement ceremony. Minister Park Jin of the Ministry of Foreign Affairs of Korea, who graduated from NYU School of Law in 1999 with a Master of Studies in Law, is one of the graduates who received President Sexton's hug.
President Emeritus Sexton, born in 1942, visited KAIST on the 17th to receive the honorary doctorate and to encourage the expedited development of the KAIST-NYU Joint Campus, for which he helped lay the foundation.
President Emeritus Sexton said, "I like the slogan, 'Onward and upward together,'" and added, "I look forward to having the two universities achieve their shared vision of becoming the world-class universities together through cooperation to establish the KAIST-NYU Joint Campus."
< Photo 2. NYU President Emeritus John Edward Sexton giving the acceptance speech at the KAIST Commencement Ceremony >
The US Ambassador to Korea, the Honorable Philip Goldberg, also attended the commencement ceremony at KAIST to congratulate President Emeritus Sexton on the conferment of the honorary doctorate. Ambassador Goldberg has been serving as the US Ambassador to Korea since July of last year.
President Kwang Hyung Lee said, “President Emeritus Sexton was a president best described as an innovator who promoted diversity in education and pursued academic excellence throughout his life.” He went on to say, “The KAIST-NYU Joint Campus, which will be completed on the foundation laid by President Emeritus Sexton, will serve as the focal point that will attract global talents flooding into New York by the driving force created from the synergy of the two universities as well as serving as a starting point for KAIST's outstanding talents to pursue their dreams toward the world.”
KAIST signed a cooperation agreement with NYU in June of 2022 to build a joint campus, and held a presentation of signage for the KAIST-NYU Joint Campus in September. Currently, about 60 faculty members are planning to begin joint research initiatives in seven fields, including robotics, AI, brain sciences, and climate change. In addition, cooperation in the field of education, including student exchange, minors, double majors, and joint degrees, is under discussion.
2023.02.17 View 6577 -
Scientists re-writes FDA-recommended equation to improve estimation of drug-drug interaction
Drugs absorbed into the body are metabolized and thus removed by enzymes from several organs like the liver. How fast a drug is cleared out of the system can be affected by other drugs that are taken together because added substance can increase the amount of enzyme secretion in the body. This dramatically decreases the concentration of a drug, reducing its efficacy, often leading to the failure of having any effect at all. Therefore, accurately predicting the clearance rate in the presence of drug-drug interaction* is critical in the process of drug prescription and development of a new drug in order to ensure its efficacy and/or to avoid unwanted side-effects.
*Drug-drug interaction: In terms of metabolism, drug-drug interaction is a phenomenon in which one drug changes the metabolism of another drug to promote or inhibit its excretion from the body when two or more drugs are taken together. As a result, it increases the toxicity of medicines or causes loss of efficacy.
Since it is practically impossible to evaluate all interactions between new drug candidates and all marketed drugs during the development process, the FDA recommends indirect evaluation of drug interactions using a formula suggested in their guidance, first published in 1997, revised in January of 2020, in order to evaluate drug interactions and minimize side effects of having to use more than one type of drugs at once.
The formula relies on the 110-year-old Michaelis-Menten (MM) model, which has a fundamental limit of making a very broad and groundless assumption on the part of the presence of the enzymes that metabolizes the drug. While MM equation has been one of the most widely known equations in biochemistry used in more than 220,000 published papers, the MM equation is accurate only when the concentration of the enzyme that metabolizes the drug is almost non-existent, causing the accuracy of the equation highly unsatisfactory – only 38 percent of the predictions had less than two-fold errors.
“To make up for the gap, researcher resorted to plugging in scientifically unjustified constants into the equation,” Professor Jung-woo Chae of Chungnam National University College of Pharmacy said. “This is comparable to having to have the epicyclic orbits introduced to explain the motion of the planets back in the days in order to explain the now-defunct Ptolemaic theory, because it was 'THE' theory back then.”
< (From left) Ph.D. student Yun Min Song (KAIST, co-first authors), Professor Sang Kyum Kim (Chungnam National University, co-corresponding author), Jae Kyoung Kim, CI (KAIST, co-corresponding author), Professor Jung-woo Chae (Chungnam National University, co-corresponding author), Ph.D. students Quyen Thi Tran and Ngoc-Anh Thi Vu (Chungnam National University, co-first authors) >
A joint research team composed of mathematicians from the Biomedical Mathematics Group within the Institute for Basic Science (IBS) and the Korea Advanced Institute of Science and Technology (KAIST) and pharmacological scientists from the Chungnam National University reported that they identified the major causes of the FDA-recommended equation’s inaccuracies and presented a solution.
When estimating the gut bioavailability (Fg), which is the key parameter of the equation, the fraction absorbed from the gut lumen (Fa) is usually assumed to be 1. However, many experiments have shown that Fa is less than 1, obviously since it can’t be expected that all of the orally taken drugs to be completely absorbed by the intestines. To solve this problem, the research team used an “estimated Fa” value based on factors such as the drug’s transit time, intestine radius, and permeability values and used it to re-calculate Fg.
Also, taking a different approach from the MM equation, the team used an alternative model they derived in a previous study back in 2020, which can more accurately predict the drug metabolism rate regardless of the enzyme concentration. Combining these changes, the modified equation with re-calculated Fg had a dramatically increased accuracy of the resulting estimate. The existing FDA formula predicted drug interactions within a 2-fold margin of error at the rate of 38%, whereas the accuracy rate of the revised formula reached 80%.
“Such drastic improvement in drug-drug interaction prediction accuracy is expected to make great contribution to increasing the success rate of new drug development and drug efficacy in clinical trials. As the results of this study were published in one of the top clinical pharmacology journal, it is expected that the FDA guidance will be revised according to the results of this study.” said Professor Sang Kyum Kim from Chungnam National University College of Pharmacy.
Furthermore, this study highlights the importance of collaborative research between research groups in vastly different disciplines, in a field that is as dynamic as drug interactions.
“Thanks to the collaborative research between mathematics and pharmacy, we were able to recify the formula that we have accepted to be the right answer for so long to finally grasp on the leads toward healthier life for mankind.,” said Professor Jae Kyung Kim. He continued, “I hope seeing a ‘K-formula’ entered into the US FDA guidance one day.”
The results of this study were published in the online edition of Clinical Pharmacology and Therapeutics (IF 7.051), an authoritative journal in the field of clinical pharmacology, on December 15, 2022 (Korean time).
Thesis Title: Beyond the Michaelis-Menten: Accurate Prediction of Drug Interactions through Cytochrome P450 3A4 Induction (doi: 10.1002/cpt.2824)
< Figure 1. The formula proposed by the FDA guidance for predicting drug-drug interactions (top) and the formula newly derived by the researchers (bottom). AUCR (the ratio of substrate area under the plasma concentration-time curve) represents the rate of change in drug concentration due to drug interactions. The research team more than doubled the accuracy of drug interaction prediction compared to the existing formula. >
< Figure 2. Existing FDA formulas tend to underestimate the extent of drug-drug interactions (gray dots) than the actual measured values. On the other hand, the newly derived equation (red dot) has a prediction rate that is within the error range of 2 times (0.5 to 2 times) of the measured value, and is more than twice as high as the existing equation. The solid line in the figure represents the predicted value that matches the measured value. The dotted line represents the predicted value with an error of 0.5 to 2 times. >
For further information or to request media assistance, please contact Jae Kyoung Kim at Biomedical Mathematics Group, Institute for Basic Science (IBS) (jaekkim@ibs.re.kr) or William I. Suh at the IBS Communications Team (willisuh@ibs.re.kr).
- About the Institute for Basic Science (IBS)
IBS was founded in 2011 by the government of the Republic of Korea with the sole purpose of driving forward the development of basic science in South Korea. IBS has 4 research institutes and 33 research centers as of January 2023. There are eleven physics, three mathematics, five chemistry, nine life science, two earth science, and three interdisciplinary research centers.
2023.01.18 View 9712 -
UAE Space Program Leaders named to be the 1st of the honorees of KAIST Alumni Association's special recognition for graduates of foreign nationality
The KAIST Alumni Association (Chairman, Chil-Hee Chung) announced on the 12th that the winners of the 2023 KAIST Distinguished Alumni Award and International Alumni Award has been selected.
The KAIST Distinguished Alumni Award, which produced the first recipient in 1992, is an award given to alumni who have contributed to the development of the nation and society, or who have glorified the honor of their alma mater with outstanding academic achievements and social and/or communal contributions.
On a special note, this year, there has been an addition to the honors, “the KAIST Distinguished International Alumni Award” to honor and encourage overseas alumni who are making their marks in the international community that will boost positive recognition of KAIST in the global setting and will later become a bridge that will expedite Korea's international efforts in the future.
As of 2022, the number of international students who succeeded in earning KAIST degrees has exceeded 1,700, and they are actively doing their part back in their home countries as leaders in various fields in which they belong, spanning from science and technology, to politics, industry and other corners of the society.
(From left) Omran Sharaf, the Assistant Minister of UAE Foreign Affairs and International Cooperation for Advanced Science and Technology, Amer Al Sayegh the Director General of Space Project at MBRSC, and Mohammed Al Harmi the Director General of Administration at MBRSC (Photos provided by the courtesy of MBRSC)
To celebrate and honor their outstanding achievements, the KAIST Alumni Association selected a team of three alumni of the United Arab Emirates (UAE) to receive the Distinguished International Alumni Award for the first time. The named honorees are Omran Sharaf, a master’s graduate from the Graduate School of Science and Technology Policy, and Amer Al Sayegh and Mohammed Al Harmi, master’s graduates of the Department of Aerospace Engineering - all three of the class of 2013 in leading positions in the UAE space program to lead the advancement of the science and technology of the country.
Currently, the three alums are in directorship of the Mohammed Bin Rashid Space Centre (MBRSC) with Mr. Omran Sharaf, who has recently been appointed as the Assistant Minister in charge of Advanced Science and Technology at the UAE Ministry of Foreign Affairs and International Cooperation, being the Project Director of the Emirates Mars Mission of MBRSC and Mr. Amer Al Sayegh in the Director General position in charge of Space Project and Mr. Mohammed Al Harmi, the Director General of Administration, at MBRSC.
They received technology transfer from “SatRec I”, Korea's first satellite system exporter and KAIST alumni company, for about 10 years from 2006, while carrying out their master’s studies at the same time.
Afterwards, they returned to UAE to lead the Emirates Mars Mission, which is already showing tangible progress including the successful launch of the Mars probe "Amal" (ال امل, meaning ‘Hope’ in Arabic), which was the first in the Arab world and the fifth in the world to successfully enter into orbit around Mars, and the UAE’s first independently developed Earth observation satellite "KhalifaSat".
An official from the KAIST Alumni Association said, "We selected the Distinguished International Alumni after evaluating their industrious leadership in promoting various space industry strategies, ranging from the development of Mars probes and Earth observation satellites, as well as lunar exploration, asteroid exploration, and Mars residence plans."
(From left) Joo-Sun Choi, President & CEO of Samsung Display Co. Ltd., Jung Goo Cho, the CEO of Green Power Co. Ltd., Jong Seung Park, the President of Agency for Defense Development (ADD), Kyunghyun Cho, Professor of New York University (NYU)
Also, four of the Korean graduates, Joo-Sun Choi, the CEO of Samsung Display, Jung Goo Cho, the CEO of Green Power Co. Ltd., Jong Seung Park, the President of Agency for Defense Development (ADD), and Kyunghyun Cho, a Professor of New York University (NYU), were selected as the winners of the “Distinguished Alumni Award”.
Mr. Joo-Sun Choi (Electrical and Electronic Engineering, M.S. in 1989, Ph.D. in 1995), the CEO of Samsung Display, led the successful development and mass-production of the world's first ultra-high-definition QD-OLED Displays, and preemptively transformed the structure of business of the industry and has been leading the way in technological innovation.
Mr. Jung Goo Cho (Electrical and Electronic Engineering, M.S. in 1988, Ph.D. in 1992), the CEO of Green Power Co. Ltd., developed wireless power technology for the first time in Korea in the early 2000s and applied it to semiconductor/display lines and led the wireless power charging technology in various fields, such as developing KAIST On-Line Electric Vehicles (OLEV) and commercializing the world's first wireless charger for 11kW electric vehicles.
Mr. Jong Seung Park (Mechanical Engineering, M.S. in 1988, Ph.D., in 1991), The President of ADD is an expert with abundant science and technology knowledge and organizational management capabilities. He is contributing greatly to national defense and security through science and technology.
Mr. Kyunghyun Cho (Computer Science, B.S., in 2009), the Professor of Computer Science and Data Science at NYU, is a world-renowned expert in Artificial Intelligence (AI), advancing the concept of 'Neural Machine Translation' in the field of natural language processing, to make great contributions to AI translation technology and related industries.
Chairman Chil-Hee Chung, the 26th Chair of KAIST Alumni Association “As each year goes by, I feel that the influence of KAIST alumni goes beyond science and technology to affect our society as a whole.” He went on to say, “This year, as it was more meaningful to extend the award to honor the international members of our Alums, we look forward to seeing more of our alumni continuing their social and academic endeavors to play an active role in the global stage in taking on the global challenges.”
The Ceremony for KAIST Distinguished Alumni and International Alumni Award Honorees will be conducted at the Annual New Year’s Event of KAIST Alumni Association for 2023 to be held on Friday, January 13th, at the Grand InterContinental Seoul Parnas.
2023.01.12 View 9992 -
An AI-based, Indoor/Outdoor-Integrated (IOI) GPS System to Bring Seismic Waves in the Terrains of Positioning Technology
KAIST breaks new grounds in positioning technology with an AI-integrated GPS board that works both indoors and out
KAIST (President Kwang Hyung Lee) announced on the 8th that Professor Dong-Soo Han's research team (Intelligent Service Integration Lab) from the School of Computing has developed a GPS system that works both indoors and outdoors with quality precision regardless of the environment.
This Indoor/Outdoor-Integrated GPS System, or IOI GPS System, for short, uses the GPS signals outdoors and estimates locations indoors using signals from multiple sources like an inertial sensor, pressure sensors, geomagnetic sensors, and light sensors. To this end, the research team developed techniques to detect environmental changes such as entering a building, and methods to detect entrances, ground floors, stairs, elevators and levels of buildings by utilizing artificial intelligence techniques. Various landmark detecting techniques were also incorporated with pedestrian dead reckoning (PDR), a navigation tool for pedestrians, to devise the so-called “Sensor-Fusion Positioning Algorithm”.
To date, it was common to estimate locations based on wireless LAN signals or base station signals in a space where the GPS signal could not reach. However, the IOI GPS enables positioning even in buildings without signals nor indoor maps.
The algorithm developed by the research team can provide accurate floor information within a building where even big tech companies like Google and Apple's positioning services do not provide. Unlike other positioning methods that rely on visual data, geomagnetic positioning techniques, or wireless LAN, this system also has the advantage of not requiring any prior preparation. In other words, the foundation to enable the usage of a universal GPS system that works both indoors and outdoors anywhere in the world is now ready.
The research team also produced a circuit board for the purpose of operating the IOI GPS System, mounted with chips to receive and process GPS, Wi-Fi, and Bluetooth signals, along with an inertial sensor, a barometer, a magnetometer, and a light sensor. The sensor-fusion positioning algorithm the lab has developed is also incorporated in the board.
When the accuracy of the IOI GPS board was tested in the N1 building of KAIST’s main campus in Daejeon, it achieved an accuracy of about 95% in floor estimation and an accuracy of about 3 to 6 meters in distance estimation. As for the indoor/outdoor transition, the navigational mode change was completed in about 0.3 seconds. When it was combined with the PDR technique, the estimation accuracy improved further down to a scope of one meter.
The research team is now working on assembling a tag with a built-in positioning board and applying it to location-based docent services for visitors at museums, science centers, and art galleries. The IOI GPS tag can be used for the purpose of tracking children and/or the elderly, and it can also be used to locate people or rescue workers lost in disaster-ridden or hazardous sites. On a different note, the sensor-fusion positioning algorithm and positioning board for vehicles are also under development for the tracking of vehicles entering indoor areas like underground parking lots.
When the IOI GPS board for vehicles is manufactured, the research team will work to collaborate with car manufacturers and car rental companies, and will also develop a sensor-fusion positioning algorithm for smartphones. Telecommunication companies seeking to diversify their programs in the field of location-based services will also be interested in the use the IOI GPS.
Professor Dong-Soo Han of the School of Computing, who leads the research team, said, “This is the first time to develop an indoor/outdoor integrated GPS system that can pinpoint locations in a building where there is no wireless signal or an indoor map, and there are an infinite number of areas it can be applied to. When the integration with the Korea Augmentation Satellite System (KASS) and the Korean GPS (KPS) System that began this year, is finally completed, Korea can become the leader in the field of GPS both indoors and outdoors, and we also have plans to manufacture semi-conductor chips for the IOI GPS System to keep the tech-gap between Korea and the followers.”
He added, "The guidance services at science centers, museums, and art galleries that uses IOI GPS tags can provide a set of data that would be very helpful for analyzing the visitors’ viewing traces. It is an essential piece of information required when the time comes to decide when to organize the next exhibit. We will be working on having it applied to the National Science Museum, first.”
The projects to develop the IOI GPS system and the trace analysis system for science centers were supported through Science, Culture, Exhibits and Services Capability Enhancement Program of the Ministry of Science and ICT.
Profile: Dong-Soo Han, Ph.D.Professorddsshhan@kaist.ac.krhttp://isilab.kaist.ac.kr
Intelligent Service Integration Lab.School of Computing
http://kaist.ac.kr/en/
Korea Advanced Institute of Science and Technology (KAIST)Daejeon, Republic of Korea
2022.07.13 View 8091 -
The 1st Global Entrepreneurship Summer Camp bridges KAIST and Silicon Valley, US
Twenty KAIST students gave a go at selling their business ideas to investors at Silicon Valley on the “Pitch Day” at 2022 Global Entrepreneurship Summer Camp.
From Tuesday, June 21 to Monday, July 4, 2022, KAIST held the first Global Entrepreneurship Summer Camp (GESC).
The 2022 GESC, which was organized in collaboration with Stanford Technology Ventures Program (STVP), KOTRA Silicon Valley IT Center, and KAIST Alumni at Silicon Valley, was a pilot program that offered opportunities of experiencing and learning about the cases of startup companies in Silicon Valley and a chance to expand businesses to Silicon Valley through networking.
Twenty KAIST students, including pre-startup entrepreneurs and students interested in global entrepreneurship with less than one year of business experience were selected. The first week of the program was organized by Startup KAIST while the second week program was organized by the Center for Global Strategies and Planning (GSP) at KAIST in collaboration with the Stanford Technology Venture Program (STVP), KAIST Alumni at Silicon Valley, and KOTRA at Silicon Valley.
Dr. Mo-Yun Lei Fong, the Executive Director of STVP, said, “The program offered an opportunity for us to realize our vision of empowering aspiring entrepreneurs to become global citizens who create and scale responsible innovation. By collaborating with KAIST and offering entrepreneurial insights to Korean students, we are able to have a positive impact on a global scale.” Mo added, “The program also enabled STVP to build bridges, learn from the students, and refine our culturally relevant curriculum by understanding Korean culture and ideas.”
On the “Pitch Day” on July 1, following a special talk by Dr. Chong-Moon Lee, the Chairman of AmBex Venture Partners, the students presented their team business ideas such as an AI-assisted, noise-canceling pillow devised for better sleep, a metaverse dating application, an XR virtual conferencing system, and an AI language tutoring application to the entice global investors’ curiosity. The invited investors, majorly based in Silicon Valley, commented that all the presentation was very exciting, and the level of pitches was beyond the expectation considering that the students have given only two weeks.
Ms. Seunghee Lee of the team “Bored KAIST Yacht Club”, which was awarded the first prize, explained, “our item, called ‘Meta-Everland’, is a service that offers real-time dating experiences similar to off-line dates. The GESC taught me that anybody can launch a startup as long as they are willing. Developing a business model from ideation and taking it to the actual pitching was challenging, but it was a very thrilling experience at the same time.” Lee added, “Most importantly, over the course of the program and the final pitch, I found out that an interesting idea can attract investors interest even at a very early stage of the launching.”
Mr. Byunghoon Hwang, a student who attended the program said, “Having learned the thoughts and attitudes the people at the front line of Silicon Valley, my views on career and launching of a start-up have been expanded a lot.”
Ms. Marina Mondragon, another attendee at the program, also said that the program was very meaningful because she was able to learn the difference between the ecosystem for the new start-up businesses at Korea and at Silicon Valley through her talks with the CEOs at Silicon Valley.
The program was co-organized by the Center for Global Strategies and Planning at KAIST International Office and Startup of KAIST. Dr. Man-Sung Yim, the Associate Vice President for KAIST International Office, who guided students in Silicon Valley, said, “I believe the GESC program broadened the views and entrepreneurial mindset of students. After joining this program, students stepped forward to become a founder of startups.” In addition, Dr. Young-Tae Kim, the Associate Vice President of the Institute for Startup KAIST, addressed “Startup KAIST will support business items founded via the program through various other programs in order to enhance their competitiveness in the global market.”
The GSP and Startup KAIST will continuously revamp the program by selecting distinguished fellows to join the program and coming up with innovative startup items.
Profile:
Sooa Lee, Ph.D.
Research Assistant Professor
slee900@kaist.ac.kr
Center for Global Strategies and Planning
Office of Global Initiatives
KAIST International Office
https://io.kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)Daejeon, Republic of Korea
2022.07.05 View 8698 -
Quantum Technology: the Next Game Changer?
The 6th KAIST Global Strategy Institute Forum explores how quantum technology has evolved into a new growth engine for the future
The participants of the 6th KAIST Global Strategy Institute (GSI) Forum on April 20 agreed that the emerging technology of quantum computing will be a game changer of the future. As KAIST President Kwang Hyung Lee said in his opening remarks, the future is quantum and that future is rapidly approaching. Keynote speakers and panelists presented their insights on the disruptive innovations we are already experiencing.
The three keynote speakers included Dr. Jerry M. Chow, IBM fellow and director of quantum infrastructure, Professor John Preskill from Caltech, and Professor Jungsang Kim from Duke University. They discussed the academic impact and industrial applications of quantum technology, and its prospects for the future.
Dr. Chow leads IBM Quantum’s hardware system development efforts, focusing on research and system deployment. Professor Preskill is one of the leading quantum information science and quantum computation scholars. He coined the term “quantum supremacy.” Professor Kim is the co-founder and CTO of IonQ Inc., which develops general-purpose trapped ion quantum computers and software to generate, optimize, and execute quantum circuits.
Two leading quantum scholars from KAIST, Professor June-Koo Kevin Rhee and Professor Youngik Sohn, and Professor Andreas Heinrich from the IBS Center for Quantum Nanoscience also participated in the forum as panelists. Professor Rhee is the founder of the nation’s first quantum computing software company and leads the AI Quantum Computing IT Research Center at KAIST.
During the panel session, Professor Rhee said that although it is undeniable the quantum computing will be a game changer, there are several challenges. For instance, the first actual quantum computer is NISQ (Noisy intermediate-scale quantum era), which is still incomplete. However, it is expected to outperform a supercomputer. Until then, it is important to advance the accuracy of quantum computation in order to offer super computation speeds.
Professor Sohn, who worked at PsiQuantum, detailed how quantum computers will affect our society. He said that PsiQuantum is developing silicon photonics that will control photons. We can’t begin to imagine how silicon photonics will transform our society. Things will change slowly but the scale would be massive.
The keynote speakers presented how quantum cryptography communications and its sensing technology will serve as disruptive innovations. Dr. Chow stressed that to realize the potential growth and innovation, additional R&D is needed. More research groups and scholars should be nurtured. Only then will the rich R&D resources be able to create breakthroughs in quantum-related industries. Lastly, the commercialization of quantum computing must be advanced, which will enable the provision of diverse services. In addition, more technological and industrial infrastructure must be built to better accommodate quantum computing.
Professor Preskill believes that quantum computing will benefit humanity. He cited two basic reasons for his optimistic prediction: quantum complexity and quantum error corrections. He explained why quantum computing is so powerful: quantum computer can easily solve the problems classically considered difficult, such as factorization. In addition, quantum computer has the potential to efficiently simulate all of the physical processes taking place in nature.
Despite such dramatic advantages, why does it seem so difficult? Professor Preskill believes this is because we want qubits (quantum bits or ‘qubits’ are the basic unit of quantum information) to interact very strongly with each other. Because computations can fail, we don’t want qubits to interact with the environment unless we can control and predict them.
As for quantum computing in the NISQ era, he said that NISQ will be an exciting tool for exploring physics. Professor Preskill does not believe that NISQ will change the world alone, rather it is a step forward toward more powerful quantum technologies in the future. He added that a potentially transformable, scalable quantum computer could still be decades away.
Professor Preskill said that a large number of qubits, higher accuracy, and better quality will require a significant investment. He said if we expand with better ideas, we can make a better system. In the longer term, quantum technology will bring significant benefits to the technological sectors and society in the fields of materials, physics, chemistry, and energy production.
Professor Kim from Duke University presented on the practical applications of quantum computing, especially in the startup environment. He said that although there is no right answer for the early applications of quantum computing, developing new approaches to solve difficult problems and raising the accessibility of the technology will be important for ensuring the growth of technology-based startups.
2022.04.21 View 8338 -
CXL-Based Memory Disaggregation Technology Opens Up a New Direction for Big Data Solution Frameworks
A KAIST team’s compute express link (CXL) provides new insights on memory disaggregation and ensures direct access and high-performance capabilities
A team from the Computer Architecture and Memory Systems Laboratory (CAMEL) at KAIST presented a new compute express link (CXL) solution whose directly accessible, and high-performance memory disaggregation opens new directions for big data memory processing. Professor Myoungsoo Jung said the team’s technology significantly improves performance compared to existing remote direct memory access (RDMA)-based memory disaggregation.
CXL is a peripheral component interconnect-express (PCIe)-based new dynamic multi-protocol made for efficiently utilizing memory devices and accelerators. Many enterprise data centers and memory vendors are paying attention to it as the next-generation multi-protocol for the era of big data.
Emerging big data applications such as machine learning, graph analytics, and in-memory databases require large memory capacities. However, scaling out the memory capacity via a prior memory interface like double data rate (DDR) is limited by the number of the central processing units (CPUs) and memory controllers. Therefore, memory disaggregation, which allows connecting a host to another host’s memory or memory nodes, has appeared.
RDMA is a way that a host can directly access another host’s memory via InfiniBand, the commonly used network protocol in data centers. Nowadays, most existing memory disaggregation technologies employ RDMA to get a large memory capacity. As a result, a host can share another host’s memory by transferring the data between local and remote memory.
Although RDMA-based memory disaggregation provides a large memory capacity to a host, two critical problems exist. First, scaling out the memory still needs an extra CPU to be added. Since passive memory such as dynamic random-access memory (DRAM), cannot operate by itself, it should be controlled by the CPU. Second, redundant data copies and software fabric interventions for RDMA-based memory disaggregation cause longer access latency. For example, remote memory access latency in RDMA-based memory disaggregation is multiple orders of magnitude longer than local memory access.
To address these issues, Professor Jung’s team developed the CXL-based memory disaggregation framework, including CXL-enabled customized CPUs, CXL devices, CXL switches, and CXL-aware operating system modules. The team’s CXL device is a pure passive and directly accessible memory node that contains multiple DRAM dual inline memory modules (DIMMs) and a CXL memory controller. Since the CXL memory controller supports the memory in the CXL device, a host can utilize the memory node without processor or software intervention. The team’s CXL switch enables scaling out a host’s memory capacity by hierarchically connecting multiple CXL devices to the CXL switch allowing more than hundreds of devices. Atop the switches and devices, the team’s CXL-enabled operating system removes redundant data copy and protocol conversion exhibited by conventional RDMA, which can significantly decrease access latency to the memory nodes.
In a test comparing loading 64B (cacheline) data from memory pooling devices, CXL-based memory disaggregation showed 8.2 times higher data load performance than RDMA-based memory disaggregation and even similar performance to local DRAM memory. In the team’s evaluations for a big data benchmark such as a machine learning-based test, CXL-based memory disaggregation technology also showed a maximum of 3.7 times higher performance than prior RDMA-based memory disaggregation technologies.
“Escaping from the conventional RDMA-based memory disaggregation, our CXL-based memory disaggregation framework can provide high scalability and performance for diverse datacenters and cloud service infrastructures,” said Professor Jung. He went on to stress, “Our CXL-based memory disaggregation research will bring about a new paradigm for memory solutions that will lead the era of big data.”
-Profile: Professor Myoungsoo Jung Computer Architecture and Memory Systems Laboratory (CAMEL)http://camelab.org School of Electrical EngineeringKAIST
2022.03.16 View 19609