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A Mathematical Model Shows High Viral Transmissions Reduce the Progression Rates for Severe Covid-19
The model suggests a clue as to when a pandemic will turn into an endemic
A mathematical model demonstrated that high transmission rates among highly vaccinated populations of COVID-19 ultimately reduce the numbers of severe cases. This model suggests a clue as to when this pandemic will turn into an endemic.
With the future of the pandemic remaining uncertain, a research team of mathematicians and medical scientists analyzed a mathematical model that may predict how the changing transmission rate of COVID-19 would affect the settlement process of the virus as a mild respiratory virus.
The team led by Professor Jae Kyoung Kim from the Department of Mathematical Science and Professor Eui-Cheol Shin from the Graduate School of Medical Science and Engineering used a new approach by dividing the human immune responses to SARS-CoV-2 into a shorter-term neutralizing antibody response and a longer-term T-cell immune response, and applying them each to a mathematical model. Additionally, the analysis was based on the fact that although breakthrough infection may occur frequently, the immune response of the patient will be boosted after recovery from each breakthrough infection.
The results showed that in an environment with a high vaccination rate, although COVID-19 cases may rise temporarily when the transmission rate increases, the ratio of critical cases would ultimately decline, thereby decreasing the total number of critical cases and in fact settling COVID-19 as a mild respiratory disease more quickly.
Conditions in which the number of cases may spike include relaxing social distancing measures or the rise of variants with higher transmission rates like the Omicron variant. This research did not take the less virulent characteristic of the Omicron variant into account but focused on the results of its high transmission rate, thereby predicting what may happen in the process of the endemic transition of COVID-19.
The research team pointed out the limitations of their mathematical model, such as the lack of consideration for age or patients with underlying diseases, and explained that the results of this study must be applied with care when compared against high-risk groups. Additionally, as medical systems may collapse when the number of cases rises sharply, this study must be interpreted with prudence and applied accordingly. The research team therefore emphasized that for policies that encourage a step-wise return to normality to succeed, the sustainable maintenance of public health systems is indispensable.
Professor Kim said, “We have drawn a counter-intuitive conclusion amid the unpredictable pandemic through an adequate mathematical model,” asserting the importance of applying mathematical models to medical research.
Professor Shin said, “Although the Omicron variant has become the dominant strain and the number of cases is rising rapidly in South Korea, it is important to use scientific approaches to predict the future and apply them to policies rather than fearing the current situation.”
The results of the research were published on medRxiv.org on February 11, under the title “Increasing viral transmission paradoxically reduces progression rates to severe COVID-19 during endemic transition.”
This research was funded by the Institute of Basic Science, the Korea Health Industry Development Institute, and the National Research Foundation of Korea.
-PublicationHyukpyo Hong, Ji Yun Noh, Hyojung Lee, Sunhwa Choi, Boseung Choi, Jae Kyung Kim, Eui-Cheol Shin, “Increasing viral transmission paradoxically reduces progression rates to
severe COVID-19 during endemic transition,” medRxiv, February 9, 2022 (doi.org/10.1101/2022.02.09.22270633)
-ProfileProfessor Jae Kyung KimDepartment of Mathematical SciencesKAIST
Professor Eui-Cheol ShinGraduate School of Medical Science and EngineeringKAIST
2022.02.22 View 7746 -
KAIST-KT AI & SW Research Center to Open
KAIST and KT will team up to advance AI technology by co-founding the “AI and SW Research Center.” Last month, President Kwang Hyung Lee and KT CEO Hyeon-Mo Ku signed the agreement to launch the center in Daejeon by the end of the year.
The KAIST-KT AI and SW Research Center will focus on exploring original technologies and industry AI that will incorporate KAIST’s excellent R&D capabilities and KT’s future AI-based business portfolio. The center will be located at the KT’s Research Center in Daejeon.
The two sides selected 15 futuristic projects for developing original technologies in the fields of sound, vision, health, and humanistic AI. In addition, the center plans to develop an AI model that can perceive and reply to precise and complex information-based situations through human conversation and detection, sound, images, and sensing.
To lay the groundwork for next-generation markets, the center will work on five industrial AI projects in the fields of media, bio, and health. Both KAIST and KT aim to lead digital innovation and changes in lifestyles by developing a next-generation AI model to follow GPT-3 (Generative Pre-Training 3) and strengthen the global competitiveness of AI technologies.
Furthermore, KT will provide infrastructure including space, equipment, and manpower to KAIST students hoping to form a start-up. A KT accelerator for start-up cultivation and investment will also help KAIST students via a start-up mentoring program. It will also run scholarship and internship programs for students who stand out during joint research projects.
President Lee said, “KT is an excellent AI R&D partner dealing with differentiated data from diverse sectors. Through the AI core technology lab, I look forward to seeing innovative technologies that will be meaningful not only for academia, but also for industry.”
2021.06.01 View 4126 -
The 1st Korea Toray Science and Technology Awardee, Prof. Sukbok Chang
(Distinguished Professor Sukbok Chang from the Department of Chemistry)
The Korea Toray Science Foundation (KTSF) awarded the first Korea Toray Science Technology Award in basic science to Distinguished Professor Sukbok Chang from the Department of Chemistry on September 19.
KTSF was established in January 2018, and its award goes to researchers who have significantly contributed to the development of chemistry and materials research with funds to support research projects.
Distinguished Professor Chang has devoted himself in organocatalysis research; in particular, his work on catalysts for effective lactam formation, which was an intricate problem, received great attention.
The award ceremony will take place in The Federation of Korean Industries Hall on October 31. KTFS board members, judges, and the CEO of Toray Industries Akihiro Nikkaku will attend the ceremony. Also, Dr. Ryoji Noyori, the Nobel Laureate in Chemistry, will give a talk on the role of chemistry and creative challenges as a researcher.
2018.10.04 View 7021 -
Extreme Materials for Fusion with Metal Cocktail
The research team under Professor Ryu Ho-jin of the Department of Nuclear and Quantum Engineering has developed a new material for facing fusion plasma environments using metal powder mixing technology. This technology is expected to extend the range of materials that can be designed for use in extreme environments such as in fusion power generators.
The durability of the tokamak vessel, which holds high-temperature plasma, is very important to create fusion power reactors, which are expected to be a future energy source. Currently, high-melting-point metals, such as tungsten, are considered plasma-facing materials to protect the tokamak vessel. However, high-energy thermal shocks, plasma ions, and neutrons are fatal to the plasma-facing material during high temperature fusion plasma operation. Therefore, it is necessary to develop new high-performance materials.
The ITER project, in which seven countries including the United States, the EU, and Korea participate jointly, is constructing a nuclear fusion experimental reactor in France with the goal of achieving the first plasma in 2025 and deuterium-tritium fusion operation in 2035. In Korea, the KSTAR tokamak at the National Fusion Research Institute has succeeded in maintaining high-performance plasma for 70 seconds.
Researchers in Europe, the United States, and China, who are leading the research on fusion plasma-facing materials, are studying the improvement of physical properties by adding a small amount of metal elements to tungsten. However, Professor Ryu’s team reported that by mixing various metals’ powders, including tungsten, they have succeeded in producing a new material that has twice the hardness and strength of tungsten. The difference in the atomic sizes of the well-mixed elements in the alloy is very significant because it makes it difficult to deform the alloy.
The team will continue its research to find alloying compositions that optimize mechanical properties as well as thermal conductivity, plasma interactions, neutron irradiation embrittlement, tritium absorption, and high-temperature oxidation properties.
Professor Ryu said, "Fusion plasma-facing materials are exposed to extreme environments and no metal is capable of withstanding thermal shock, plasma, and neutron damage simultaneously. As a result of this research, attempts to develop complex metallic materials for nuclear fusion and nuclear power are expected to become more active around the world. "
Ph.D. candidate Owais Ahmed Waseem is the first author of this project. The research is supported by the Ministry of Science, ICT and Future Planning, the Korea Research Foundation's Fusion Basic Research project, and the Engineering Research Center. The results were published in 'Scientific Report' on May 16.
Figure 1. Tungsten-based high strengh alloy sample
Figure 2. Fusion plasma facing material development by powder processing of refractory elements
2017.05.26 View 8568 -
Top 10 Emerging Technologies by World Economic Forum
The World Economic Forum’s Meta-Council on Emerging Technologies announced its annual list of breakthrough technologies, the “Top 10 Emerging Technologies of 2016,” on June 23, 2016. The Meta-Council chose the top ten technologies based on the technologies’ potential to improve lives, transform industries, and safeguard the planet. The research field of systems metabolic engineering, founded by Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at KAIST, was also citied. Systems metabolic engineering, which combines elements of synthetic biology, systems biology, and evolutionary engineering, offers a sustainable process for the production of useful chemicals in an environmentally friendly way from plants such as inedible biomass, reducing the need of using fossil fuels. Details about the list follow below:
https://www.weforum.org/press/2016/06/battery-powered-villages-sociable-robots-rank-among-top-10-emerging-technologies-of-2016
The picture below shows the “systems metabolic engineering of E. coli for the production of PLGA." PLGA is poly(lactate-co-glycolate), which is widely used for biomedical applications, and has been made by chemical synthesis. Now it is possible to produce PLGA eco-friendly by one-step fermentation of a gut bacterium which is developed through systems metabolic engineering.
2016.06.27 View 9671 -
International workshop on healthcare technology to be held on campus, April 24, 2012
KAIST and the KTH Royal Institute of Technology (KTH), Sweden, host a joint workshop on healthcare technologies on Tuesday, April 24, at the LG Semicon Hall (N24).
Open to the public, the workshop will proceed with presentations and discussions by participants from both institutions. Presentation topics and speakers are as follows:
“Applied medical engineering, innovation from clinical problems” by Professor Lars-Åke Brodin, Dean of School of Technology and Health, KTH
“ICT in healthcare” by Professor Björn-Erik Erlandsson, School of Technology and Health, KTH
“Department of environmental physiology, human research in extreme environments” by Researcher Mikael Grönkvist, School of Technology and Health, KTH
“Brain function imaging using high-resolution MRI technology” by Professor Hyun Wook Park, Department of Electrical Engineering, KAIST
“Bioinstrumentation for healthcare and physical human robot interactions” by Professor Jung Kim, Division of Mechanical Engineering, KAIST
“A portable high-resolution near-infrared spectroscopy system” by Professor Hyeon-Min Bae, Department of Electrical Engineering, KAIST
“Lab-on-a-chip technologies for integrative bioengineering” by Professor Je-Kyun Park, Department of Bio and Brain Engineering, KAIST
“The cytoskeleton in cancer and regulation by oncogenic signaling” by Professor David M. Helfman, Department of Biological Sciences, KAIST
Professor Chang Dong Yoo, Associate Vice President of Office of Special Projects and Institutional Relations at KAIST, who organized the workshop, says “Aging population and health issues are driving the demand for more sophisticated medical devices, procedures, and most importantly, qualified scientists and engineers specialized in health-related fields. This joint workshop will be a great chance to share new ideas and develop joint research between two leading research-oriented universities in two countries.”
Partially supported by LG Ericsson in Korea, the workshop is funded largely by the generous donation, made last June by a Swedish couple, to KAIST scholar exchange program.
The couple (Rune Jonasson and Kerstin Jonasson) donated 70 million krona (about 11.8 billion Korean won) to KTH last year and requested that some portion of the sum be used for a scholar exchange program with KAIST. The wife of the couple, Kerstin Jonasson, participated in the Korean War as a nurse, and upon her wish for further development in Korea’s science and technology, KAIST and KTH decided to use the donation for research in the field of healthcare and for a post-doc researcher exchange program.
KTH is a world-class university of Sweden and has produced numerous researchers for private enterprises, like Ericsson, and venture businesses. Since 1988, KTH offers a top notch program for information technology; the School of Information and Communication Technology is located in the Kista district, a vibrant cluster of information and communications technology industries in Sweden, and has taken on the crucial role of supplying personnel to the Kista Science Park as well as to academic-industrial cooperation.
For any inquiries, please contact the International Relations Team at +82-42-350-2441 (email: jungillee@kaist.ac.kr).
2012.04.21 View 10625 -
Kaist expresses appreciation to a Swedish nurse served in the Korean War and donated a scholarship.
Public release date: 19-Dec-2011
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Contact: Lan Yoon
hlyoon@kaist.ac.kr
82-423-502-295
The Korea Advanced Institute of Science and Technology (KAIST)
Kaist expresses appreciation to a Swedish nurse served in the Korean War and donated a scholarship
The largest private donation ever given to KTH Royal Institute of Technology in Stockholm, Sweden, will include a scholarship for KAIST students to study there
The largest private donation ever given to KTH Royal Institute of Technology in Stockholm, Sweden, will include a scholarship for KAIST students to study there.
"I"ve never forgotten the tragedy of the Korean War that I witnessed as a nurse, even today, more than 60 years later. I"m glad to contribute to a wider cooperation in science and technology between Sweden and Korea," said the donor.
Daejeon, Republic of Korea, December 19, 2011— On Monday, December 19th, 2011 at 4:00 pm (Central European Time), at KTH Royal Institute of Technology (KTH) in Stockholm, KAIST (Korea Advanced Institute of Science and Technology) presented a plaque of appreciation to a Swedish couple, Rune and Kerstin Jonasson, whose generous donation will establish a scholarship fund for KAIST students.
In late June of 2011, the Jonassons donated 70 million Krona ($10 million USD) to KTH, the largest lump sum donation ever given to the university by an individual, and the couple requested that a portion of the money be used to promote academic interaction and collaboration with Korean universities. KTH had various student exchange programs with KAIST, and with the financial support from the Jonassons, the two universities have decided to invite KAIST students to study at KTH.
Enjoying a long tradition of excellence in higher education in Asia and Northern Europe, KAIST and KTH have continued to lead the development of science and technology through top-notch educational programs, dynamic research experiences, technological innovation, and highly skilled and motivated manpower. The two global research universities expect that the scholarship program will add another dimension to already expanding exchanges.
Kerstin Jonasson, 88 years old, came to Korea in 1951 when she was 28, and served a six-month tour of duty as a nurse in the Korean War. Recalling her past, Mrs. Jonasson said, "The calamity of the war remains deeply engraved in my mind." Ever since returning from the battlefield, she has been seeking ways to help Korea, and has thus been regularly involved in volunteer activities to strengthen bilateral relations between Korea and Sweden.
Chang-Dong Yoo, Associate Vice President of Special Projects & Institutional Relations at KAIST, thanked the couple while presenting them with the award on behalf of KAIST family including President Nam-Pyo Suh.
"We feel greatly indebted to the Jonassons, most particularly to Kerstin Jonasson, who came to Korea during the toughest time in our modern history and rendered generous humanitarian assistance to Koreans. Not only that, Mrs. Jonasson has continued to play an important role, up to today, as a "Goodwill Ambassador for Korea" in bringing the two countries closer than ever. This scholarship will provide our students with excellent opportunities to study in Sweden, the home of many great scientists, as well as to experience the robust and vibrant Nordic culture."
In response, Kerstin Jonasson said:
"I"m grateful to the Korean people who, over the past 60 years, have consistently expressed their appreciation for my work during the Korean War, and I"m really proud of the fact that they"ve made Korea a great country, reemerging from the destitution of the war as an important power of democracy and economy in the world. My husband and I hope that our donation will further enhance the strong ties forged between Sweden and Korea, and that KTH and KAIST will become the centerpiece of a mutually beneficial relationship between the two countries through the advancement of science and technology."
The details of the scholarship have yet to be finalized, but the fund is expected to be approximately 10 to 15 million Krona ($1.4~$2.1 million USD) to be spread out over five years. KAIST aims to begin sending students to KTH in the fall of 2012, and will select 10~12 graduate students for the exchange program. Since 1990, 38 KAIST students have studied at KTH, and 50 KTH students have studied at KAIST.
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2011.12.23 View 8870 -
Ten Breakthroughs of the Year 2011 by Science
Porous Zeolite Crytals
Science, an internationally renowned scientific journal based in the US, has recently released a special issue of “Breakthrough of the Year, 2011,” dated December 23, 2011. In the issue, the journal introduces ten most important research breakthroughs made this year, and Professor Ryong Ryoo, Department of Chemistry at KAIST, was one of the scientists behind such notable advancements in 2011. Professor Ryoo has been highly regarded internationally for his research on the development of synthetic version of zeolites, a family of porous minerals that is widely used for products such as laundry detergents, cat litters, etc. Below is the article from Science, stating the zeolite research:
For Science’s “Breakthrough of the Year, 2011”, please go to:
http://www.sciencemag.org/site/special/btoy2011/
[Excerpt from the December 23, 2011 Issue of Science]
Industrial Molecules, Tailor-Made
If you ever doubt that chemistry is still a creative endeavor, just look at zeolites. This family of porous minerals was first discovered in 1756. They"re formed from different arrangements of aluminum, silicon, and oxygen atoms that crystallize into holey structures pocked with a perfect arrangement of pores. Over the past 250 years, 40 natural zeolites have been discovered, and chemists have chipped in roughly 150 more synthetic versions.
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Porous zeolite crystals are widely used as filters and catalysts. This year, researchers found new ways to tailor the size of their pores and create thinner, cheaper membranes.
CREDIT: K. VAROON ET AL., SCIENCE334, 6052 (7 OCTOBER 2001)
This abundance isn"t just for show. Three million tons of zeolites are produced every year for use in laundry detergents, cat litter, and many other products. But zeolites really strut their stuff in two uses: as catalysts and molecular sieves. Oil refineries use zeolite catalysts to break down long hydrocarbon chains in oil into the shorter, volatile hydrocarbons in gasoline. And the minerals" small, regularly arranged pores make them ideal filters for purifying everything from the air on spaceships to the contaminated water around the nuclear reactors destroyed earlier this year in Fukushima, Japan.
Zeolites have their limitations, though. Their pores are almost universally tiny, making it tough to use them as catalysts for large molecules. And they"re difficult to form into ultrathin membranes, which researchers would like to do to enable cheaper separations. But progress by numerous teams on zeolite synthesis this year gave this “mature” area of chemistry new life.
Researchers in South Korea crafted a family of zeolites in which the usual network of small pores is surrounded by walls holed with larger voids. That combination of large and small pores should lead to catalysts for numerous large organic molecules.
Labs in Spain and China produced related large- and small-pore zeolites by using a combination of inorganic and organic materials to guide the structures as they formed.
Meanwhile, researchers in France and Germany discovered that, by carefully controlling growth conditions, they could form a large-pore zeolite without the need for the expensive organic compounds typically used to guide their architecture as they grow. The advance opens the way for cheaper catalysts. In yet another lab, researchers in Minnesota came up with a new route for making ultrathin zeolite membranes, which are likely to be useful as a wide variety of chemically selective filters.
This surge of molecular wizardry provides a vivid reminder that the creativity of chemists keeps their field ever young.
Related References and Web Sites
2011.12.23 View 11364 -
KAIST establishes Indoor Location Recognition Industrial-Educational Research Center
KAIST has signed the memorandum of understanding on the 15th of February for the establishment of ‘KTNET-KAIST Industrial-Educational Research Center’ (Head of Center, Professor Han Dong Soo of department of Computer Sciences). Korea International Trade Association and KTNET will be working with KAIST to develop wi-fi based indoor location recognition service and applications of the developed technology.
The memorandum of understanding states that KTNET and Korea International Trade Association will be allowed access to the technology KAIST has in order to obtain competitive advantage in the field of location recognition.
In addition, KAIST will continue on making technological advances in the field of wi-fi based indoor location recognition for the next 5 years, develop new core technologies and applications, along with the export of related technologies abroad, under the support of the KITA and KTNET.
The KTNET-KAIST research center is special in that it has been derived off of the technology developed for the hosting of the G20 Global Summit. Last year, KAIST, KITA, and KTNET developed a wi-fi based Coex indoor navigation system and called it ‘myCoex’ and released it to the public in tandem with hosting G20 Summit.
‘myCoex’ application was the first of its kind in the world to provide wi-fi based indoor navigation system without problems. Despite ‘myCoex’ only useable within Coex, over 150,000 users have downloaded the application.
The research center plans on developing the necessary technology that will allow the application of such an app like ‘mCoex’ to large indoor spaces like Incheon International Airport, subway, shopping malls, and etc.
In addition the addition of a social commerce service to ‘myCoex’ is being looked into which will be the marriage of navigation services and social commerce services.
The KTNET KAIST research center will develop a wi-fi based indoor location recognition service platform that can be widely used and open it so that numerous other developers can develop personalized services.
Han Dong Soo Head od Center commented, “The wi-fi based indoor location recognition technology is still found wanting in its accuracy, response time, and energy consumption efficiency making further research imperative in this particular field. The establishment of KTNET-KAIST research center has created a research friendly environment and KAIST will do its utmost to become the leader in the field”.
2011.02.21 View 11129 -
Board Chairman Chung Makes First Visit to Building Named After Him
Moon-Soul Chung, chairman of the KAIST board of trustees, visited the building built with his donation on Monday (Oct. 19) for the first time since he made the deed of gift eight years ago, university authorities said on Monday (Oct. 19).
In 2000, Chung, founder and former CEO of Mirae Corp, manufacturer of semiconductor testing equipment, announced retirement and handed over the presidency of his company to one of his managing directors. One year later in 2001, he donated 30 billion won, then equivalent to $30 million, to KAIST. It was by then the largest amount given by a single donor.
The major part of his donation went to constructing a building for the newly-established Department of Bio and Brain Engineering, and it was named after him. However, Chung did not attend the ground-breaking and dedication ceremonies, saying that he would not enter the building until KAIST achieved a breakthrough technology which can inject a hope to Koreans.
On his first visit to the building, he was briefed on the major research outcomes of the department over the past seven years, which were highlighted by the recent invention of an apparatus for measuring perfusion rate of legs. A KAIST team headed by Prof. Chul-Hee Choi invented a light leakage prevention unit including a light emitting device for radiating light having a certain wavelength onto a living body injected with Indocyanine Green (ICG).
According to Prof. Choi, the invention relates to an apparatus for measuring the perfusion rate of legs. The invention also includes a light leakage prevention housing formed to prevent transmission of external light.
Chung expressing satisfaction with the achievements and encouraged professors, researchers and students working at the Moon-Soul Chung Building.
2009.10.20 View 12817 -
KAIST Undergraduates Open Four-Day International Conference
The ICISTS-KAIST, an annual international conference organized by KAIST undergraduate students, opened on Thursday (Aug. 20) at the KAIST"s main campus in Daejeon.
The 2009 ICISTS (International Conference for the Integration of Science and Technology into Society) drew around 200 experts and students from 44 countries. Since its inception in 2005 to promote discourse on important science and technology issues affecting modern society, the conference has served as an opportunity for academic networking among students in various parts of the world.
The four-day conference consists of lectures, open discussions among lecturers and students, field trips to help students to understand actual applications, and team projects.
This year"s conference offers three workshops under the themes of "Climate Change: Merging Technology and Policy for Green Solutions"; "Human-Computer Interaction: Designing Computer System for Intuitive Human Access"; and "Nano Clinic: Breakthrough in Conquering Disease."
Lectures by invited experts in various scientific fields will help broaden students" perspectives particularly from interdisciplinary viewpoints, said an organizer of the conference.
2009.08.28 View 13524
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133 Diplomats Worldwide Visit KAIST
THE KAIST Herald April 8, 2004by jong-kyoung Kim
On March 12, diplomatic corps in Korea visited Daedeok Valley"s KAIST after taking a trial run on the Korea Train eXpress(KTX). Composed of ambassadors from 79 nations and 54 international organizations, the 133 diplomatic corps went on board KTX at 10:30 AM in Seoul and arrived in Daejeon at 11:20 AM.
Shortly after arrival, the diplomatic corps attended a luncheon hosted by the Minister of Foreign Affairs and Trade(MOFAT) before paying visits to the Electronics and Telecommunications Research Institute(ETRI) and KAIST. After being introduced to the current issues at KAIST, the diplomatic corps returned back to Seoul at 4:00 PM.
Seventy-nine embassy representatives out of eighty-seven currently stationed in Korea participated in this event, with fifty-four representatives from three international organizations. In addition, officials from the Ministry of Foreign Affairs and Trade, a commercial relations director, and a regional representative accompanied them.
The trial rides on April 1 were organized by the Ministry of Foreign Affairs and Trade to publicize Korea as being the fifth country (after Japan, France, Germany, and Spain) in the world to own an express train and to introduce the growth of Korea"s IT industry through visits to ETRI and KAIST.
Events such as this are held annually to improve the understandings of the diplomatic corps about Korea"s science, technology, culture and art and to further enhance bilateral relations.
2004.04.20 View 16218