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Establishment of System Metabolic Engineering Strategies
Although conventional petrochemical processes have generated chemicals and materials which have been useful to mankind, they have also triggered a variety of environmental problems including climate change and relied too much on nonrenewable natural resources. To ameliorate this, researchers have actively pursued the development of industrial microbial strains around the globe in order to overproduce industrially useful chemicals and materials from microbes using renewable biomass. This discipline is called metabolic engineering.
Thanks to advances in genetic engineering and our knowledge of cellular metabolism, conventional metabolic engineering efforts have succeeded to a certain extent in developing microbial strains that overproduce bioproducts at an industrial level. However, many metabolic engineering projects launched in academic labs do not reach commercial markets due to a failure to fully integrate industrial bioprocesses.
In response to this, Distinguished Professor Sang Yup Lee and Dr. Hyun Uk Kim, both from the Department of Chemical and Biomolecular Engineering at KAIST, have recently suggested ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. Systems metabolic engineering differs from conventional metabolic engineering by incorporating traditional metabolic engineering approaches along with tools of other fields, such as systems biology, synthetic biology, and molecular evolution.
The ten strategies of systems metabolic engineering have been featured in Nature Biotechnology released online in October 2015, which is entitled "Systems strategies for developing industrial microbial strains."
The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects. Specifically, they consist of: 1) project design including economic evaluation of a target bioproduct; 2) selection of host strains to be used for overproduction of a bioproduct; 3) metabolic pathway reconstruction for bioproducts that are not naturally produced in the selected host strains; 4) increasing tolerance of a host strain against the bioproduct; 5) removing negative regulatory circuits in the microbial host limiting overproduction of a bioproduct; 6) rerouting intracellular fluxes to optimize cofactor and precursor availability necessary for the bioproduct formation; 7) diagnosing and optimizing metabolic fluxes towards product formation; 8) diagnosis and optimization of microbial culture conditions including carbon sources; 9) system-wide gene manipulation to further increase the host strain's production performance using high-throughput genome-scale engineering and computational tools; and 10) scale-up fermentation of the developed strain and diagnosis for the reproducibility of the strain's production performance.
These ten strategies were articulated with successful examples of the production of L-arginine using Corynebacterium glutamicum, 1,4-butanediol using Escherichia coli, and L-lysine and bio-nylon using C. glutamicum.
Professor Sang Yup Lee said, "At the moment, the chance of commercializing microbial strains developed in academic labs is very low. The strategies of systems metabolic engineering outlined in this analysis can serve as guidelines when developing industrial microbial strains. We hope that these strategies contribute to improving opportunities to commercialize microbial strains developed in academic labs with drastically reduced costs and efforts, and that a large fraction of petroleum-based processes will be replaced with sustainable bioprocesses."
Lee S. Y. & Kim, H. U. Systems Strategies for Developing Industrial Microbial Strains. Nature Biotechnology (2015).
This work was supported by the Technology Development Program to Solve Climate Change on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) from the Ministry of Science, ICT and Future Planning (MSIP), Korea, and through the National Research Foundation (NRF) of Korea. This work was also supported by the Novo Nordisk Foundation.
Picture: Concept of the Systems Metabolic Engineering Framework
(a) Three major bioprocess stages (b) Considerations in systems metabolic engineering to optimize the whole bioprocess. List of considerations for the strain development and fermentation contribute to improving microbial strain's production performance (red), whereas those for the separation and purification help in reducing overall operation costs by facilitating the downstream process (blue). Some of the considerations can be repeated in the course of systems metabolic engineering.
2015.10.19 View 10986 -
Professor Ki-Jun Jeong Wins the 2015 Dam Yeun Academic Award
The 11th Dam Yeun Academic Award presented by the Korean Society for Biotechnology and Bioengineering (KSBB) to a biologist under 45 years old went to Professor Ki-Jun Jeong of the Chemical and Biomolecular Engineering Department at KAIST.
The award ceremony took place on October 13, 2015, at the annual conference of KSBB held at Songdo Convensia in Incheon City.
Each year KSBB announces the recipient of the award based on the publications by researchers in the last five years at peer-reviewed international journals or KSBB Journal as well as the record of patent registration and technology transfers.
Professor Jeong is recognized for his pioneering research in protein, antibody, cellular engineering, and protein displays and chips.
2015.10.19 View 9350 -
KAIST Agrees to Personnel Exchange with the Ministry of Economic Affairs of the Republic of China
A delegation from the Ministry of Economic Affairs (MOEA) of the Republic of China (ROC) visited KAIST on October 16, 2015.
President Steve Kang of KAIST and Director General Yu-Ping Lien of the Department of Investment Services, MOEA, signed a memorandum of understanding (MOU) on exchanging personnel, recruiting and attracting top talents, and sharing job information.
With the MOU, KAIST and MOEA will develop a mobility program for students in Korea and ROC to help them seek employment opportunities in both nations. Director General Lien hoped that the MOU would bring more of KAIST students in the information technology field to work in ROC.
President Kang responded,
“KAIST has fostered highly talented engineers and researchers across all fields of science and engineering. If these students can have a place in ROC to realize their potential, this certainly could benefit the two nations.”
In the picture from left to right is Director General Yu-Ping Lien of the Department of Investment Services, the Ministry of Economic Affairs of the Republic of China and President Steve Kang of KAIST.
2015.10.17 View 5528 -
Visit by Danish Folk High School: Vallekilde Højskole
A group of 60 Danish students and teachers from Vallekilde Højskole, one of 70 Folk High Schools that are spread across Denmark, visited KAIST on October 16, 2015.
The Danish delegation and KAIST’s student organization, the International Conference for the Integration of Science, Technology, and Society (ICISTS), jointly ran a conference entitled “Learning through Having Fun and Games.”
At the conference, the Headmaster of Game Academy at Vallekilde Højskole, Thomas Vigild, gave a lecture on how Vallekilde Folk High School is educating new generations with play, curiosity, and collaboration.
During the conference, KAIST and Danish students held an event called the PlayShop, which was hosted by Headmaster Vigild. At the PlayShop, some 80 students from both institutions enjoyed Danish folk games and shared cross-cultural experiences.
The Danish Folk High School, which dates back to 1844 when its first school opened in Southern Denmark, started as a civic school offering equal learning opportunities to people less fortunate to receive a regular education.
Today, the Folk High School has grown into life-long educational institutions that provide Danish citizens from high school students to seniors with alternative, complementary education that allows citizens to venture out into new fields of their interest or further hone their professional skills and knowledge.
Established in 1865, the Vallekilde Folk High School specializes in journalism, game development, event management, literature, crafts, youth leadership, music and design. Its game development classes at the Game Academy are known for helping students reach their potential through learning from fun games, creative initiatives, and collaborative projects.
The invitation of the Danish school was made possible by Director Heekyung Park of the Institute of Disaster Studies at KAIST.
Director Park said,
“In a sense, I could say that all Danish Folk High Schools are an ideal form of delivering education. They pursue ways to teach students without losing their curiosity and interest in subjects. The schools remove any type of exams from classrooms, while striving to ensure the maximum participation of students in the learning process. KAIST could emulate some of these educational practices to offer its students a classroom free of stress and full of inspirations.”
The Danish delegation toured KAIST’s Humanoid Research Center and the Urban Robotics Lab after the conference.
2015.10.16 View 5883 -
KAIST's Moon Soul Graduate School of Future Strategy Names Recipients of Science Journalism Awards
The Science Journalism Masters Program of the Moon Soul Graduate School of Future Strategy at KAIST named the winners of the 2015 Science Journalism Awards on October 17, 2015. The award ceremony took place at KAIST’s Seoul campus.
The awards were created in 2011 to recognize exemplary journalism that has contributed to the advancement of science and technology in Korea.
This year, the Korean Broadcasting System’s science show called the “Jang Yeong-Sil Show” received the Grand Prize. Yeong-Sil Jang was a Korean scientist and astronomer during the Joseon Dynasty in the 14th century.
A television documentary on challenges facing farm-raised chickens, which was produced by the Munhwa Broadcasting Corporation in Jeonju City, won the TV Award, while news coverage by Dong-A Daily on the outbreak of the Middle East respiratory Syndrome (MERS) in Korea received the Print Award.
After the award ceremony, students and professors of the Science Journalism Program hosted a conference to review and discuss major issues covered by the news media in the past year.
2015.10.15 View 7082 -
KAIST Teams Up with Korean Universities for MOOCs
KAIST, Seoul National University (SNU), and the Pohang University of Science and Technology (POSTECH) agreed to cooperate in the development of Massive Open Online Courses (MOOCs) for Korean viewers. The agreement ceremony took place at the SNU campus on October 14, 2015.
Under the agreement, professors from all three universities will jointly create and implement online courses on science and engineering by the summer of 2016. The MOOCs will largely consist of basic courses on physics, chemistry, life science, mechanical engineering, and material science. Anyone from a high school student to an adult who is interested in science can take these online courses.
Some of the participating professors will be President Doh-Yeon Kim of POSTECH, Dean Seong-Keun Kim of Natural Sciences College at SNU, Dean Kun-Woo Lee of Engineering College at SNU, Dean Jung-Hoe Kim of Life Science and Bioengineering College at KAIST, Dean Do-Kyung Kim of Academic Affairs at KAIST, Dean Kun-Hong Lee of Engineering College at POSTECH, and Dean Joon-Won Park of Science College at POSTECH.
President Steve Kang of KAIST said,
“Many of Korea’s most distinguished professors in science and engineering will participate in the MOOCs. People, particularly young students aspiring to study science and technology at universities, should definitely take advantage of this opportunity.”
In the picture from left to right is President Steve Kang of KAIST, President Nak-In Sung of Seoul National University, and President Doh-Yeon Kim of Pohang University of Science and Technology.
2015.10.14 View 7870 -
KAIST's College of Business Places Fourth in the 2015 Better World MBA Ranking
The Corporate Knights, a business and society magazine based in Canada, released the results of the 2015 Better World MBA Ranking on October 8, 2015.
KAIST’s business school ranked fourth globally and, number one in Asia, according to the list.
The 2015 Corporate Knights Better World MBA Ranking included a total of 121 schools; York University’s Schulich School of Business of Canada took first place.
The rankings were based on three criteria: the number of curricula (core and required courses) dedicated to sustainability, the number of research institutions and centers at the business school, and the volume of faculty research focused on better world topics such as sustainable finance, clean energy, or gender diversity.
The Better World MBA Ranking aims to identify business schools that best equip graduates who seek to change the world for the better by offering students opportunities to learn how to integrate social and environmental factors in their understanding of management functions via core MBA courses, faculty expertise, and research centers.
Dean Dong-Seok Kim of the College of Business at KAIST said,
“For years, our school has introduced a wide range of programs and research initiatives that address important social needs and issues. As part of this effort, we created the Graduate School of Green Growth and MBA for Social Entrepreneurship back in 2013. I believe that these endeavors played a favorable role in our receiving high scores in the ranking.”
KAIST’s Graduate School of Green Growth previously ranked sixth in the world’s top Green MBA School list published by Corporate Knights.
For the 2015 Better World MBA Ranking, go to
http://www.corporateknights.com/reports/2015-global-sustainable-mba/11153-14442629/.
2015.10.12 View 5466 -
Professor Key-Sun Choi Receives the Order of Service Merit Green Stripes from the Korean Government
The award recognizes Professor Choi’s life-long research effort to make Korean language digitally available, both nationally and internationally.
Professor Key-Sun Choi of the School of Computing at KAIST received the Order of Service Merit Green Stripes from the Korean government at the 569th Korean Language Day, held annually to commemorate the invention of the Korean language, Hangeul. The ceremony took place on October 9, 2015, at the Sejong Center in Seoul.
Professor Choi has distinguished himself in the field of natural language processing (NLP), including Korean language. He developed a Korean NLP parser that enabled information processing and data analysis of Korean language, as well as a digital Korean dictionary, contributing to the advancement of Korean language-based information technology.
Professor Choi also led the way to widespread use of Korean natural language in computing by developing and commercializing open source software to process the Korean language.
He has served leading roles in many of the international academic societies and standardization organizations, among others, as the vice president of Infoterm (the International Information Center for Terminology), president of the Asia Federation of Natural Language Processing, vice chair of ISO/TC 37, a technical committee in the International Organization for Standardization (ISO), and a council member for the International Association of Machine Translation.
2015.10.08 View 8957 -
Yang-Hann Kim named recipient of the Rossing Prize in Acoustics Education by the Acoustical Society of America
Courtesy of the Acoustical Society of America (ASA)
Press release issued by ASA on October 8, 2015:
Yang-Hann Kim named recipient of the Rossing Prize in Acoustics Education by the Acoustical Society of America
Melville (NY), 8 October 2015—Yang-Hann Kim, Professor at KAIST (Korea Advanced Institute of Science and Technology), Daejeon, has been named recipient of the Acoustical Society of America (ASA) Rossing Prize in Acoustics Education. The Rossing Prize is awarded to an individual who has made significant contributions toward furthering acoustics education through distinguished teaching, creation of educational materials, textbook writing and other activities. The Prize will be presented at the 170th meeting of the ASA on 4 November 2015 in Jacksonville, Florida.
“It is my great honor to receive the Rossing Prize, which has been given to outstanding scholar members of ASA since 2003. I never dreamed to be one of them.” said Kim. “I must express my deep respect and love to my friend Thomas Rossing: I have known him more than 20 years, always respect what he has done for teaching, writing books, and pioneering work in musical acoustics.”
Yang-Hann Kim is a Fellow of the Acoustical Society of America. He received a Ph.D. from the Massachusetts Institute of Technology. His main research interests in acoustics began with “sound visualization” resulted in the development of the “sound camera” which makes any sound visible instantly. Then he moved to “sound manipulation.” Using his manipulation technology, one can move any sound in space and time, positioning sound, and can create a private sound zone. Sound Visualization and Manipulation, (Wiley, 2013), summarizes these two fields. Dr. Kim’s textbook, Sound Propagation: An Impedance Based Approach (John Wiley and Sons, 2010), is well acknowledged by the associated professional communities as one of best acoustics textbooks. Using his teaching experience at KAIST, he created a YouTube lecture on acoustics and vibration which is also available in MOOC (Massive Open Online Course). He has also presented lectures to over 500 engineers and technicians for the past 30 years.
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The Acoustical Society of America (ASA) is the premier international scientific society in acoustics devoted to the science and technology of sound. Its 7000 members worldwide represent a broad spectrum of the study of acoustics. ASA publications include the Journal of the Acoustical Society of America—the world’s leading journal on acoustics, Acoustics Today magazine, books, and standards on acoustics. The Society also holds two major scientific meetings per year. For more information about the Society visit our website, www.acousticalsociety.org.
2015.10.06 View 9650 -
Professor Kyung-Won Chung Receives the 2015 Design Value Awards
The Design Management Institute (DMI) announced eleven winners of its 2015 Design Value Awards.
Professor Kyung-Won Chung of the Industrial Design Department at KAIST took one of the four First Place Design Value Awards. The award ceremony was held on September 28, 2015, at the Royal Sonesta Hotel in Boston.
DMI is an international organization that has actively advocated for the strategic value of design, sponsoring research, publishing academic papers, connecting members across disciplines and the globe, and sharing best design practices.
Commemorating its 40th anniversary, DMI created the inaugural Design Value Awards this year, which honors the contributions of design teams who have delivered significant value through design or design management practices.
There were four categories of the awards: first, second, and third prize, and Honorable Mention. The first place had four winners; both the second and third took two winners each. The honorable mention included three awardees.
The award noted Professor Chung's contributions to the development of design management theory and practices in Korea and his dedication to elevate KAIST’s industrial design department to one of the 30 leading design institutions in the world during his 30-year career at the university.
DMI also appointed Professor Chung a Life Fellow.
Professor Chung said,
“I am greatly honored to receive such a significant award, the equivalent of the Academy Awards in the field of design. I hope this award will encourage the further development of the Korean design industry to lead the global design community.”
He has served in various important positions in public and private organizations, including as the president of the Korea Institute of Design Promotion, Vice Mayor of Design for the City of Seoul, Advisor to the Design Division of Samsung Electronics, and a member of organizing committee of the International Council of Societies of Industrial Design.
2015.10.04 View 7388 -
Nikon Instruments Korea Donates a Fund to KAIST's Department of Biological Sciences
Representatives from Nikon Instruments Korea Co., Ltd., a producer of microscopes and measuring instruments, visited the KAIST campus on September 25, 2015, and donated USD 9,000 to the Department of Biological Sciences at KAIST.
A small ceremony to mark the donation took place at the department’s conference room.
In the picture from left to right were Professor Won-Do Heo, Department Head Byung-Ha Oh, Professor Sangyong Jon, President Sam-Sup Jang of Korea Instech, and Director Ik-Soo Yoo of Nikon Instruments Korea.
The department announced that the fund would be used to build its new research center to house the state-of-the-art research equipment and tools for the development of new medicine.
2015.10.03 View 5333 -
Professor Junehwa Song Appointed as the General Chair of the Organizing Committee of ACM SenSys
Professor Junehwa Song from the Schooling of Computing at KAIST has been appointed the general chair of the organizing committee of ACM SenSys—the American Computing Machine (ACM) Conference on Embedded Networked Sensor Systems.
ACM SenSys held its first conference in 2003 to promote research on wireless sensor networks and embedded systems. Since then, it has expanded into an influential international conference especially with the increasing importance in sensor technologies. Recently the committee has expanded its field of interest to mobile sensors, the Internet of Things, smart device system, and security.
Professor Song is considered a world-renown researcher in mobile and ubiquitous computing system. He presented numerous research papers at various conferences organized by ACM. He is also a member of the editorial committee of the Institute of Electrical and Electronics Engineers (IEEE) Transactions on Mobile Computing journal. For his achievements in the field and flair for coordinating and planning conferences, he is now the first Korean researcher to be appointed the chair of ACM SenSys.
Professor Song said that, as the chair, he would help discover new technology in and applications of networked, wireless sensors that would meet the demands of our modern society.
The 13th ACM SenSys will take place in Seoul—the first one to be held in Asia. The event will begin on November 1, 2015 and last four days. More information about this year’s event can be found at http://sensys.acm.org/2015/.
2015.10.02 View 7768