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Study Finds Player-Character Relationships Affected Game Satisfaction in the Last of Us Part II
Research analyzed player experiences with a polarizing game and found differences in how the players related to their characters
The action adventure game ‘The Last of Us’ was a big hit worldwide in 2014. However, its sequel, the Last of Us Part II divided opinions in the game community when it was released in 2020.
A research team from the Games and Life Lab in the Graduate School of Culture Technology at KAIST analyzed why the game players’ reviews were so polarized and found that player-character relationships influenced the game players’ satisfaction. This study, published in Frontiers in Psychology, will help developers of character-driven games foresee how different players will react to their games.
The team under Professor Young Yim Doh conducted in-depth interviews with 12 players from diverse nations, both those satisfied and dissatisfied with the game.
The team found that three elements affected the game players’ satisfaction. First, players’ satisfaction varied according to their tolerance of forced character switches. When a player is forced to switch their controlled figure in the game to another character that is introduced as the antagonist, most players initially had a negative reaction. The feeling of being forced to play in a way they didn’t want reduced their rights as a player. However, later on, some players viewed this character switch as an interesting transition and were more tolerant toward forced game play.
Second, the researchers found that the flexibility of character attachment is related to game satisfaction. Players who were unhappy about the game resisted building a relationship with the new antagonist character. Meanwhile, players who were happy about the game slowly formed an additional relationship with the new character. This led to the player feeling conflicting emotions, which satisfied players considered a meaningful experience of understanding a perspective of someone initially considered the enemy.
Lastly, the satisfaction of the play depended on how much the players could accept a changing character image in the game. Dissatisfied players found inconsistencies in the characters’ behavior and did not accept the new information about the characters. Meanwhile, satisfied players tried to understand and accept the new information and actions.
“Previous research on narrative games focused more on the game design than on the players’ experiences. To understand why reactions to the game were very different across players, we focused our research on differences in the players’ psychological experiences with the game.” said lead author and Master’s candidate Valérie Erb.
Co-author Dr. Seyeon Lee added, “This suggests that there is no one way to satisfy all players in a character-based narrative game. To satisfy a game’s players, it is important to understand the different players in the player base, target the right player group, and manage expectations accordingly.”
This research was supported by the Year 2020 Culture Technology R&D Program by the Ministry of Culture, Sports and Tourism and the Korea Creative Content Agency.
-PublicationErb V, Lee S, and Doh YY (2021) “Player-Character Relationship and Game Satisfaction in Narrative Game: Focus on Player Experience of Character Switch in The Last of Us Part II”
Frontiers in Psychology. 12:709926. (https://doi.org/10.3389/fpsyg.2021.709926)
-ProfileProfessor Young Yim DohGames and Life LabGraduate School of Culture TechnologyKAIST
2021.11.15 View 4687 -
Marien Buissonniere Awarded the 9th Grand Award for Future Strategy
Global healthcare and humanitarian activist honored by the Grand Award for Future Strategy
The Moon Soul Graduate School of Future Strategy awarded the 9th Grand Award for Future Strategy to Marine Buissonniere, an independent advisor and practitioner in the fields of global health and humanitarian action. She currently works as a senior advisor to the Prevent Epidemics team at Resolve to Save Lives. She also co-chairs Doctors Without Borders’ Transformational Investment Capacity.
Buissonniere was recognized for designing and implementing global response strategies in global strife and disaster stricken areas over the 25 years while serving as secretary general of Doctors Without Borders. She has been working with various government agencies around the world including Resolve to Save Lives to respond to the Covid-19 pandemic and preparing global future strategies for the post-pandemic era.
The Grand Award for Future Strategy recognizes individual and organization who have contributed to the nation and humanity through future research and strategies in the fields of science and technology, economy and industry, society and culture, politics and governance, and resources and environment.
The selection committee place particular emphasis on her humanitarian efforts toward North Korea. She was in charge of the task force for resuming the health project in North Korea and facilitated the North Korean program in 2002. She also played a significant role in raising awareness of North Korea’s humanitarian issues in the international community by lecturing at Columbia and Princeton.
Buissonniere said during the awards ceremony held online on November 5, “I am very grateful to receive this award from KAIST, a world’s top-flight university as well as from South Korea related to the Korean Peninsula and North Korea, where I have spent most of my life. What makes this award even more special is it is about the international medical relief activities and system innovations that I’ve devoted my life to over the last 25 years. I am going to continue this journey to help many people in difficult situations. Eventually, I would like to make it possible for those people in need to make their own future by themselves.”
2021.11.11 View 5233 -
Nanoscale Self-Assembling Salt-Crystal ‘Origami’ Balls Envelop Liquids
Mechanical engineers have devised a ‘crystal capillary origami’ technique where salt crystals spontaneously encapsulate liquid droplets
Researchers have developed a technique whereby they can spontaneously encapsulate microscopic droplets of water and oil emulsion in a tiny sphere made of salt crystals—sort of like a minute, self-constructing origami soccer ball filled with liquid. The process, which they are calling ‘crystal capillary origami,’ could be used in a range of fields from more precise drug delivery to nanoscale medical devices.The technique is described in a paper appearing in the journal Nanoscale on September 21.
Capillary action, or ‘capillarity,’ will be familiar to most people as the way that water or other liquids can move up narrow tubes or other porous materials seemingly in defiance of gravity (for example within the vascular systems of plants, or even more simply, the drawing up of paint between the hairs of a paintbrush). This effect is due to the forces of cohesion (the tendency of a liquid’s molecules to stick together), which results in surface tension, and adhesion (their tendency to stick to the surface of other substances). The strength of the capillarity depends on the chemistry of the liquid, the chemistry of the porous material, and on the other forces acting on them both. For example, a liquid with lower surface tension than water would not be able to hold up a water strider insect.
Less well known is a related phenomenon, elasto-capillarity, that takes advantage of the relationship between capillarity and the elasticity of a very tiny flat sheet of a solid material. In certain circumstances, the capillary forces can overcome the elastic bending resistance of the sheet.
This relationship can be exploited to create ‘capillary origami,’ or three-dimensional structures. When a liquid droplet is placed on the flat sheet, the latter can spontaneously encapsulate the former due to surface tension. Capillary origami can take on other forms including wrinkling, buckling, or self-folding into other shapes. The specific geometrical shape that the 3D capillary origami structure ends up taking is determined by both the chemistry of the flat sheet and that of the liquid, and by carefully designing the shape and size of the sheet.
There is one big problem with these small devices, however. “These conventional self-assembled origami structures cannot be completely spherical and will always have discontinuous boundaries, or what you might call ‘edges,’ as a result of the original two-dimensional shape of the sheet,” said Kwangseok Park, a lead researcher on the project. He added, “These edges could turn out to be future defects with the potential for failure in the face of increased stress.” Non-spherical particles are also known to be more disadvantageous than spherical particles in terms of cellular uptake.
Professor Hyoungsoo Kim from the Department of Mechanical Engineering explained, “This is why researchers have long been on the hunt for substances that could produce a fully spherical capillary origami structure.”
The authors of the study have demonstrated such an origami sphere for the first time. They showed how instead of a flat sheet, the growth of salt-crystals can perform capillary origami action in a similar manner. What they call ‘crystal capillary origami’ spontaneously constructs a smooth spherical shell capsule from these same surface tension effects, but now the spontaneous encapsulation of a liquid is determined by the elasto-capillary conditions of growing crystals.
Here, the term ‘salt’ refers to a compound of one positively charged ion and another negatively charged. Table salt, or sodium chloride, is just one example of a salt. The researchers used four other salts: calcium propionate, sodium salicylate, calcium nitrate tetrahydrate, and sodium bicarbonate to envelop a water-oil emulsion. Normally, a salt such as sodium chloride has a cubical crystal structure, but these four salts form plate-like structures as crystallites or ‘grains’ (the microscopic shape that forms when a crystal first starts to grow) instead. These plates then self-assemble into perfect spheres.
Using scanning electron microscopy and X-ray diffraction analysis, they investigated the mechanism of such formation and concluded that it was ‘Laplace pressure’ that drives the crystallite plates to cover the emulsion surface. Laplace pressure describes the pressure difference between the interior and exterior of a curved surface caused by the surface tension at the interface between the two substances, in this case between the salt water and the oil.
The researchers hope that these self-assembling nanostructures can be used for encapsulation applications in a range of sectors, from the food industry and cosmetics to drug delivery and even tiny medical devices.
-Publication
Kwangseok Park, Hyoungsoo Kim “Crystal capillary origami capsule with self-assembled nanostructure,” Nanoscale, 13(35), 14656-14665 (DOI: 10.1039/d1nr02456f)
-Profile
Professor Hyoungsoo Kim
Fluid and Interface Laboratory
http://fil.kaist.ac.kr
Department of Mechanical Engineering
KAIST
2021.11.04 View 7421 -
Metaverse Factory Center to Improve SME’s Competitiveness
The center is expected to enhance the manufacturing competitiveness of SMEs and root industry
KAIST opened the ‘Metaverse Factory Experience Center for Manufacturing AI’ on November 1 at the KAIST Bigdata Center for Manufacturing AI. The AI-powered manufacturing metaverse factory will provide real-life experiences for the analysis and application of manufacturing data. Funded by the Ministry of SMEs and Startups, the center is a collaboration with Digiforet, which donated the software system to KAIST.
The center allows users to experience the collection, analysis, and utilization process of manufacturing data equivalent to that of real manufacturing sites. Users can connect to the service from anywhere in the world using AR/VR/XR equipment and a metaverse solution, which allows small and middle-sized domestic manufacturing companies to overcome the challenges of entering and selling their production lines overseas in the post-COVID-19 era. The platform is an opportunity for such companies to introduce and export their excellent manufacturing techniques.
With the same manufacturing and AI processes of real production sites, the injection molding metaverse factory for plastic screw production runs simulations of the products they will make. Based on the data collection parameters (temperature, pressure, speed, location, time, etc.) built into the Korea AI Manufacturing Platform, an AI-powered SME manufacturing platform, the metaverse factory can detect causes of defects, provide analysis, and guide improvements in productivity and product quality.
Starting with the injection molding equipment metaverse factory, the platform aims to expand into plating, welding, molding, casting, forging, and annealing, and become a root industry to contribute greatly to enhancing the manufacturing competitiveness of Korea’s small and middle-sized root industries.
Il-Joong Kim, head of the KAIST Manufacturing AI Bigdata Center where the metaverse factory is located, said, “To successfully incorporate manufacturing AI into production sites, it is indispensable that various AI algorithms are tested to optimize decisions. The platform allows users to collect manufacturing data and to experience and test AI analysis simultaneously without interrupting the production process, making it highly effective.”
KAIST President Kwang Hyung Lee said, “We will support the close academic-industrial cooperation with Digiforet such as this collaborative for improving SMEs’ competitiveness.”
Digiforet CEO Sunghoon Park, who donated a whole HW/SW interface for the construction of the Metaverse Factory Experience Center for Manufacturing AI, said, “I will do my best to realize the best “Metaverse Factory for Manufacturing AI” in the world by combining the AI and bigdata accumulated at KAIST and Digiforet’s XR metaverse technology.”
2021.11.03 View 5834 -
New Chiral Nanostructures to Extend the Material Platform
Researchers observed a wide window of chiroptical activity from nanomaterials
A research team transferred chirality from the molecular scale to a microscale to extend material platforms and applications. The optical activity from this novel chiral material encompasses to short-wave infrared region.
This platform could serve as a powerful strategy for hierarchical chirality transfer through self-assembly, generating broad optical activity and providing immense applications including bio, telecommunication, and imaging technique. This is the first observation of such a wide window of chiroptical activity from nanomaterials.
“We synthesized chiral copper sulfides using cysteine, as the stabilizer, and transferring the chirality from molecular to the microscale through self-assembly,” explained Professor Jihyeon Yeom from the Department of Materials Science and Engineering, who led the research. The result was reported in ACS Nano on September 14.
Chiral nanomaterials provide a rich platform for versatile applications. Tuning the wavelength of polarization rotation maxima in the broad range is a promising candidate for infrared neural stimulation, imaging, and nanothermometry. However, the majority of previously developed chiral nanomaterials revealed the optical activity in a relatively shorter wavelength range, not in short-wave infrared.
To achieve chiroptical activity in the short-wave infrared region, materials should be in sub-micrometer dimensions, which are compatible with the wavelength of short-wave infrared region light for strong light-matter interaction. They also should have the optical property of short-wave infrared region absorption while forming a structure with chirality.
Professor Yeom’s team induced self-assembly of the chiral nanoparticles by controlling the attraction and repulsion forces between the building block nanoparticles. During this process, molecular chirality of cysteine was transferred to the nanoscale chirality of nanoparticles, and then transferred to the micrometer scale chirality of nanoflowers with 1.5-2 2 μm dimensions formed by the self-assembly.
“We will work to expand the wavelength range of chiroptical activity to the short-wave infrared region, thus reshaping our daily lives in the form of a bio-barcode that can store vast amount of information under the skin,” said Professor Yeom.
This study was funded by the Ministry of Science and ICT, the Ministry of Health and Welfare, the Ministry of Food and Drug Safety, the National Research Foundation of Korea,the KAIST URP Program, the KAIST Creative Challenging Research Program, Samsung and POSCO Science Fellowship.
-PublicationKi Hyun Park, Junyoung Kwon, Uichang Jeong, Ji-Young Kim, Nicholas A.Kotov, Jihyeon Yeom, “Broad Chrioptical Activity from Ultraviolet to Short-Wave Infrared by Chirality Transfer from Molecular to Micrometer Scale," September 14, 2021 ACS Nano (https://doi.org/10.1021/acsnano.1c05888)
-ProfileProfessor Jihyeon YeomNovel Nanomaterials for New Platforms LaboratoryDepartment of Materials Science and EngineeringKAIST
2021.10.22 View 7998 -
Flexible Sensor-Integrated RFA Needle Leads to Smarter Medical Treatment
Clinical trial of flexible sensor-integrated radiofrequency ablation (RFA) needle tip monitors physical changes and steam pop
Researchers have designed a thin polymeric sensor platform on a radiofrequency ablation needle to monitor temperature and pressure in real time. The sensors integrated onto 1.5 mm diameter needle tip have proven their efficacy during clinical tests and expect to provide a new opportunity for safer and more effective medical practices. The research was reported in Advanced Science as the frontispiece on August 5.
Radiofrequency ablation (RFA) is a minimally invasive surgery technique for removing tumors and treating cardiovascular disease. During a procedure, an unintended audible explosion called ‘steam pop’ can occur due to the increased internal steam pressure in the ablation region. This phenomenon has been cited as a cause of various negative thermal and mechanical effects on neighboring tissue. Even more, the relationship between steam pop and cancer recurrence is still being investigated.
Professor Inkyu Park said that his team’s integrated sensors reliably detected the occurrence of steam pop. The sensors also monitor rapidly spreading hot steam in tissue. It is expected that the diverse properties of tissue undergoing RFA could be checked by utilizing the physical sensors integrated on the needle.
“We believe that the integrated sensors can provide useful information about a variety of medical procedures and accompanying environmental changes in the human body, and help develop more effective and safer surgical procedures,” said Professor Park.
Professor Park’s team built a thin film type pressure and temperature sensor stack with a thickness of less than 10 μm using a microfabrication process. For the pressure sensor, the team used contact resistance changes between metal electrodes and a carbon nanotube coated polymeric membrane. The entire sensor array was thoroughly insulated with medical tubes to minimize any exposure of the sensor materials to external tissue and maximize its biocompatibility.
During the clinical trial, the research team found that the accumulated hot steam is suddenly released during steam pops and this hot air spreads to neighboring tissue, which accelerates the ablation process. Furthermore, using in-situ ultrasound imaging and computational simulations, the research team could confirm the non-uniform temperature distribution around the RFA needle can be one of the primary reasons for the steam popping.
Professor Park explained that various physical and chemical sensors for different targets can be added to create other medical devices and industrial tools.
“This result will expand the usability and applicability of current flexible sensor technologies. We are also trying to integrate this sensor onto a 0.3mm diameter needle for in-vivo diagnosis applications and expect that this approach can be applied to other medical treatments as well as the industrial field,” added Professor Park. This study was supported by the National Research Foundation of Korea.
-PublicationJaeho Park, Jinwoo Lee, Hyo Keun Lim, Inkyu Park et al. “Real-Time Internal Steam Pop Detection during Radiofrequency Ablation with a Radiofrequency Ablation Needle Integrated with a Temperature and Pressure Sensor: Preclinical and clinical pilot tests," Advanced Science (https://doi/org/10.1002/advs.202100725) on August 5, 2021
-ProfileProfessor Inkyu ParkMicro & Nano Tranducers Laboratory http://mintlab1.kaist.ac.kr/
Department of Mechanical EngineeringCollege of EngineeringKAIST
2021.10.20 View 6753 -
Deep Learning Framework to Enable Material Design in Unseen Domain
Researchers propose a deep neural network-based forward design space exploration using active transfer learning and data augmentation
A new study proposed a deep neural network-based forward design approach that enables an efficient search for superior materials far beyond the domain of the initial training set. This approach compensates for the weak predictive power of neural networks on an unseen domain through gradual updates of the neural network with active transfer learning and data augmentation methods.
Professor Seungwha Ryu believes that this study will help address a variety of optimization problems that have an astronomical number of possible design configurations. For the grid composite optimization problem, the proposed framework was able to provide excellent designs close to the global optima, even with the addition of a very small dataset corresponding to less than 0.5% of the initial training data-set size. This study was reported in npj Computational Materials last month.
“We wanted to mitigate the limitation of the neural network, weak predictive power beyond the training set domain for the material or structure design,” said Professor Ryu from the Department of Mechanical Engineering.
Neural network-based generative models have been actively investigated as an inverse design method for finding novel materials in a vast design space. However, the applicability of conventional generative models is limited because they cannot access data outside the range of training sets. Advanced generative models that were devised to overcome this limitation also suffer from weak predictive power for the unseen domain.
Professor Ryu’s team, in collaboration with researchers from Professor Grace Gu’s group at UC Berkeley, devised a design method that simultaneously expands the domain using the strong predictive power of a deep neural network and searches for the optimal design by repetitively performing three key steps.
First, it searches for few candidates with improved properties located close to the training set via genetic algorithms, by mixing superior designs within the training set. Then, it checks to see if the candidates really have improved properties, and expands the training set by duplicating the validated designs via a data augmentation method. Finally, they can expand the reliable prediction domain by updating the neural network with the new superior designs via transfer learning. Because the expansion proceeds along relatively narrow but correct routes toward the optimal design (depicted in the schematic of Fig. 1), the framework enables an efficient search.
As a data-hungry method, a deep neural network model tends to have reliable predictive power only within and near the domain of the training set. When the optimal configuration of materials and structures lies far beyond the initial training set, which frequently is the case, neural network-based design methods suffer from weak predictive power and become inefficient.
Researchers expect that the framework will be applicable for a wide range of optimization problems in other science and engineering disciplines with astronomically large design space, because it provides an efficient way of gradually expanding the reliable prediction domain toward the target design while avoiding the risk of being stuck in local minima. Especially, being a less-data-hungry method, design problems in which data generation is time-consuming and expensive will benefit most from this new framework.
The research team is currently applying the optimization framework for the design task of metamaterial structures, segmented thermoelectric generators, and optimal sensor distributions. “From these sets of on-going studies, we expect to better recognize the pros and cons, and the potential of the suggested algorithm. Ultimately, we want to devise more efficient machine learning-based design approaches,” explained Professor Ryu.This study was funded by the National Research Foundation of Korea and the KAIST Global Singularity Research Project.
-Publication
Yongtae Kim, Youngsoo, Charles Yang, Kundo Park, Grace X. Gu, and Seunghwa Ryu, “Deep learning framework for material design space exploration using active transfer learning and data augmentation,” npj Computational Materials (https://doi.org/10.1038/s41524-021-00609-2)
-Profile
Professor Seunghwa Ryu
Mechanics & Materials Modeling Lab
Department of Mechanical Engineering
KAIST
2021.09.29 View 9375 -
Two Researchers Designated as SUHF Fellows
Professor Taeyun Ku from the Graduate School of Medical Science and Engineering and Professor Hanseul Yang from the Department of Biological Sciences were nominated as 2021 fellows of the Suh Kyungbae Foundation (SUHF).
SUHF selected three young promising scientists from 53 researchers who are less than five years into their careers. A panel of judges comprised of scholars from home and abroad made the final selection based on the candidates’ innovativeness and power to influence. Professor You-Bong Hyun from Seoul National University also won the fellowship.
Professor Ku’s main topic is opto-connectomics. He will study ways to visualize the complex brain network using innovative technology that transforms neurons into optical elements.
Professor Yang will research the possibility of helping patients recover from skin diseases or injuries without scars by studying spiny mouse genes.
SUHF was established by Amorepacific Group Chairman Suh Kyungbae in 2016 with 300 billion KRW of his private funds. Under the vision of ‘contributing to humanity by supporting innovative discoveries of bioscience researchers,’ the foundation supports promising Korean scientists who pioneer new fields of research in biological sciences.
From 2017 to this year, SUHF has selected 20 promising scientists in the field of biological sciences. Selected scientists are provided with up to KRW 500 million each year for five years. The foundation has provided a total of KRW 48.5 billion in research funds to date.
2021.09.15 View 6440 -
MCM Utilized at Residential Treatment Center in Gyeonggi
The Mobile Clinic Module (MCM) developed by the KAIST Action for Respiratory Epidemics was installed at special residential treatment center in Gyeonggi Province on September 13.
The MCM is an isolate negative pressure unit fitted with high-quality medical equipment, developed by Professor Taek-Jin Nam of the Department of Industrial Design under the KAIST New Deal R&D Initiative. This is also a part of the Korean Disease Control Package Development Project from last July.
In January, a ward with four beds for critical care was installed at the Korea Institute for Radiological & Medical Sciences in Seoul for a trial operation, and two mild cases were treated there. It was also implemented as an isolated negative pressure unit in the Daejeon Konyang University Hospital emergency room in June, and has treated 138 cases since.
The special residential treatment center installed in the Gyeonggi Provincial Academy gymnasium, which consists of 28 beds in 14 rooms (double occupancy) and a multipurpose room (for X-rays and treatment), is to remain open through October 10. Unlike existing treatment centers that have quarantined COVID-19 patients for two weeks, the Gyeonggi MCM will act as a self-treatment-associated short-term treatment center. While in self-treatment, patients showing symptoms requiring special attention will be moved to the MCM, followed by short-term hospitalization of 1-3 days for observation before further measures are taken.
Patients can be treated using the MCM’s own treatment capacities, including in-person and oxygen treatment, X-rays, and IVs. There are individual bathrooms in each room, and the pressure, ventilation, and the automatic opening and closing of the entrance can be centrally monitored and controlled. Patients showing symptoms during treatment will be moved to a specially designated hospital for critical care, and will return to the self-treatment center if no further abnormalities are reported.
The Gyeonggi Provincial Medical Center’s Ansung Hospital will take charge of operating the special treatment center. Each day, one or two doctors, three nurses, two nursing assistants, one administrative staff member, two or three disinfection specialists, and a medical imaging engineer will work in three shifts. There will also be about 20 additional specially designated staff members including KAIST researchers, firefighters, and police officers.
The MCM was internationally recognized as an excellent medical facility not only for its functionality, economic feasibility, and utility, but also for its unique design and aesthetics. It received two Best of Best awards at the Red Dot Award in product design and Communication Design in user interface.
By running this special treatment center, KAIST will conduct research on how to build an optimized model for efficient negative pressure medical units. This research is expected to lead to advances in waste water treatment systems, mobile bathrooms optimized for infectious cases, and MCM user interfaces for electronic devices, etc.
Professor Taek-Jin Nam, the general director of the project and design, said “if there is a gymnasium available, we can convert it into a special treatment center fitted with a waste water treatment system, and pressure equipment in two weeks even without additional infrastructure.”
The head of the KAIST New Deal R&D Initiative Choongsik Bae said, “our MCM research started in July of last year, and in just over a year, it has become a successful and innovative case that has undergone trials and become commercialized in a short period of time.” He added, “In response to COVID-19, KAIST is conducting research and empirical studies, not just in relation to the MCM, but in other areas of disease control as well.”
Based on the excellent disease control technologies developed by KAIST research teams, the KAIST Action for Respiratory Epidemics is conducting technology transfers and industrialization, and is developing a Korean disease control package model
2021.09.15 View 8974 -
Professor Il-Doo Kim Receives the Science Minister’s Award
Professor Il-Doo Kim from the Department of Materials Science and Engineering received the Science and ICT Minister’s Award in recognition of his commercialization and technology transfer achievements during the Day of IP celebration.
Professor Kim, who has made over 222 patents application and registration home and abroad, has advanced toxic gas detection and breath gas sensor technology by arraying nanosensor fibers. His technological advances in micro-electro-mechanical systems (MEMS) helped to advance the commercialization of the MEMS-related sensor and improve its overall competitiveness.
He founded the Il-Doo Kim Research Center in 2019 and focuses on the commercialization of nanofiber manufacturing through electrospinning and highly efficient nanofiber filters. For instance, he succeeded in manufacturing a nano-filter recyclable mask that maintains excellent filtering efficiency even after hand washing through the development of proprietary technology that aligns nanofibers with a diameter of 100~500 nanometers in orthogonal or unidirectional directions.
Professor Kim also serves as an associate editor at ACS Nano. He said, “The importance of IP goes without saying. I look forward to the registration and application of more KAIST patents leading to commercialization, paving the way for national technological competitiveness.”
2021.09.15 View 5616 -
The Dynamic Tracking of Tissue-Specific Secretory Proteins
Researchers develop a versatile and powerful tool for studying the spatiotemporal dynamics of secretory proteins, a valuable class of biomarkers and therapeutic targets
Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. This method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1.
Secretory proteins released into the blood play essential roles in physiological systems. They are core mediators of interorgan communication, while serving as biomarkers and therapeutic targets.
Previous studies have analyzed conditioned media from culture models to identify cell type-specific secretory proteins, but these models often fail to fully recapitulate the intricacies of multi-organ systems and thus do not sufficiently reflect biological realities.
These limitations provided compelling motivation for the research team led by Jae Myoung Suh and his collaborators to develop techniques that could identify and resolve characteristics of tissue-specific secretory proteins along time and space dimensions.
For addressing this gap in the current methodology, the research team utilized proximity-labeling enzymes such as TurboID to label secretory proteins in endoplasmic reticulum lumen using biotin. Thereafter, the biotin-labeled secretory proteins were readily enriched through streptavidin affinity purification and could be identified through mass spectrometry.
To demonstrate its functionality in live mice, research team delivered TurboID to mouse livers via an adenovirus. After administering the biotin, only liver-derived secretory proteins were successfully detected in the plasma of the mice. Interestingly, the pattern of biotin-labeled proteins secreted from the liver was clearly distinctive from those of hepatocyte cell lines.
First author Kwang-eun Kim from the Graduate School of Medical Science and Engineering explained, “The proteins secreted by the liver were significantly different from the results of cell culture models. This data shows the limitations of cell culture models for secretory protein study, and this technique can overcome those limitations. It can be further used to discover biomarkers and therapeutic targets that can more fully reflect the physiological state.”
This work research was supported by the National Research Foundation of Korea, the KAIST Key Research Institutes Project (Interdisciplinary Research Group), and the Institute for Basic Science in Korea.
-PublicationKwang-eun Kim, Isaac Park et al., “Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice,” Nature Communications on Sept.1,
2021(https://doi.org/10.1038/s41467-021-25546-y)
-ProfileProfessor Jae Myoung Suh Integrated Lab of Metabolism, Obesity and Diabetes Researchhttps://imodkaist.wixsite.com/home
Graduate School of Medical Science and Engineering College of Life Science and BioengineeringKAIST
2021.09.14 View 7394 -
Digital Big Bang, Metaverse Technologies
The GSI Forum 2021 will explore the potential of new metaverse technologies that will change our daily lives
KAIST will be hosting a live online international forum on Sept.8 at 9 am (KST) through its KAIST YouTube channel. The forum will explore global trends regarding metaverse technology innovations and applications and discuss how we can build a new technology ecosystem.
Titled `Digital Big Bang, Metaverse Technology,' the Global Strategy Institute-International Forum 2021 will be the fourth event of its kind, following the three international forums held in 2020. The forum will delve into the development trends of metaverse platforms and AR/VR technologies and gather experts to discuss how such technologies could transform multiple aspects of our future, including education.
President Kwang Hyung Lee explains in his opening remarks that new technologies are truly opening a new horizon for our lives, saying, “In the education sector, digital technology will also create new opportunities to resolve the longstanding pedagogical shortfalls of one-way knowledge delivery systems. New digital technologies will help to unlock the creativity of our students. Education tailored to the students’ individual levels will not only help them accumulate knowledge but improve their ability to use it. Universities around the world are now at the same starting line. We should carve out our own distinct metaverse that is viable for human interactions and diverse technological experiences that promote students’ creativity and collaborative minds.”
Minster of Science and ICT Hyesook Lim will introduce how the Korean government is working to develop metaverse industries as a new potential engine of growth for the future in her welcoming remarks. The government’s efforts include collaborations with the private sector, investments in R&D, the development of talent, and regulatory reforms. Minister Lim will also emphasize the importance of national-level discussions regarding the establishment of a metaverse ecosystem and long-term value creation.
The organizers have invited global experts to share their knowledge and insights.
Kidong Bae, who is in charge of the KT Enterprise Project and ‘Metaverse One Team’ will talk about the current trends in the metaverse market and their implications, as well as KT’s XR technology references. He will also introduce strategies to establish and utilize a metaverse ecosystem, and highlight their new technologies as a global leader in 5G networks.
Jinha Lee, co-founder and CPO of the American AR solution company Spatial, will showcase a remote collaboration office that utilizes AR technology as a potential solution for collaborative activities in the post-COVID-19 era, where remote working is the ‘new normal.’ Furthermore, Lee will discuss how future workplaces that are not limited by space or distance will affect our values and creativity.
Professor Frank Steinicke from the University of Hamburg will present the ideal form of next-generation immersive technology that combines intelligent virtual agents, mixed reality, and IoT, and discuss his predictions for how the future of metaverse technology will be affected.
Marco Tempest, a creative technologist at NASA and a Director’s Fellow at the MIT Media Lab, will also be joining the forum as a plenary speaker. Tempest will discuss the potential of immersive technology in media, marketing, and entertainment, and will propose a future direction for immersive technology to enable the sharing of experiences, emotions, and knowledge.
Other speakers include Beomjoo Kim from Unity Technologies Korea, Professor Woontaek Woo from the Graduate School of Culture Technology at KAIST, Vice President of Global Sales at Labster Joseph Ferraro, and CEO of 3DBear Jussi Kajala. They will make presentations on metaverse technology applications for future education.
The keynote session will also have an online panel consisting of 50 domestic and overseas metaverse specialists, scientists, and teachers. The forum will hold a Q&A and discussion session where the panel members can ask questions to the keynote speakers regarding the prospects of metaverse and immersive technologies for education.
GSI Director Hoon Sohn stated, "KAIST will seize new opportunities that will arise in a future centered around metaverse technology and will be at the forefront to take advantage of the growing demand for innovative science and technology in non-contact societies. KAIST will also play a pivotal role in facilitating global cooperation, which will be vital to establish a metaverse ecosystem.”
2021.09.07 View 7475