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KAIST and Hanwha Chemical Agree on Research Collaboration
KAIST signed a memorandum of understanding (MOU) with Hanwha Chemical Co., Ltd., a Korean chemical and auto manufacturer, on November 2, 2015 to establish a research center on campus.
The research center, which will be named “KAIST-Hanwha Chemical Future Technology Research Center,” will implement joint research projects for five years beginning from 2016 to develop innovative, green technologies that will help the Korean chemical industry boost its global competitiveness and to nurture top researchers and engineers in chemical engineering.
The research center will lead the development of next-generation petrochemical materials and manufacturing technology and the establishment of pure high-refining processes which are more energy-efficient and environmentally friendly. KAIST and Hanwha will strive to secure new technologies that have the greatest commercialization potential in the global market. They will also establish a scholarship fund for 15 KAIST doctoral students in the Department of Chemical and Biomolecular Engineering.
Many professors from the Chemical and Biomolecular Engineering Department including Distinguished Professor Sang Yup Lee, who was listed in the Top 20 Translational Researchers of 2014 by Nature Biotechnology this year, and Professor Hyunjoo Lee who received the Woman Scholar award at the 2015 World Chemistry Conference, will work at the research center.
Professor Lee, the head of the research center, said, “Collaborating with Hanwha will give us a strong basis for our efforts to carry out original research and train the best researchers in the field.”
Chang-Bum Kim, the Chief Executive Officer (CEO) of Hanwha Chemical, said,
“We hope our collaborations with KAIST will go beyond the typical industry and university cooperation. The two organizations will indeed jointly operate the research center, and this will become a new model for industry and university cooperation. We expect that the research center will play a crucial role in the development of new products and technologies to grow the Korean chemical industry.”
In the photo, President Steve Kang of KAIST (fourth from left) and CEO Chang-Bum Kim of Hanwha Chemical (fifth from left) hold the MOU together.
2015.11.01 View 9826 -
The 2015 Intelligent SoC Robot War Finals
The final round of the 2015 Intelligent SoC (System on Chip) Robot War took place from October 29, 2015 to November 1, 2015 at Kintex in Ilsan, Korea.
A “SoC robot” refers to an intelligent robot capable of autonomous object recognition and decision making by employing advanced semiconductor and information technology.
First hosted in 2002, the Intelligent SoC Robot War cultivates top talents in the field of semiconductors and seeks to revitalize Korea’s information technology (IT) and semiconductor industries.
The event consists of two competitions: HURO and the Tae Kwon Do Robot.
In the HURO competition, participating robots sequentially complete eight assignments without outside controls. Whichever robot finishes the highest number of tasks and spends the shortest amount of time for the completion of assignments wins the competition.
At the HURO competition, a SoC robot overcomes obstacles.
The Tae Kwon Do Robot competition includes Korea’s traditional martial arts into robotics. Here, the winner is selected by sparring between a pair of competitors. The camera attached to the robot’s head recognizes the position of the opponent and the distance between them. From that, the robot takes actions such as punching or kicking.
Two robots are vying for the title of the Tae Kwon Do Robot.
This year, 570 people from 104 teams from all over the nation applied, and after preliminaries, 26 teams entered the finals.
The winners of the HURO and Tae Kwon Do Robot competitions receive awards from the president and prime minister of Korea, respectively.
The Chairman of the Intelligent SoC Robot War, Professor Hoi-Jun Yoo of Electrical Engineering Department at KAIST, said,
“Korea’s strength in semiconductors and information technology can serve as a great potential to advance the development of intelligent robots. We hope that our experiences in this competition will allow Korea to excel in this field.”
2015.11.01 View 9003 -
KAIST Invites Entrepreneurs and Experts to Participate in a Social Technology Innovation Symposium
The Research Institute for Social Technology and Innovation (RISTI) at KAIST hosted the Social Technology Innovation Symposium on November 4, 2015 in KI building, to which 100 social business entrepreneurs and experts in the field were invited.
Social businesses refer to activities of companies, which strive to resolve social problems such as environmental issues, income inequality, and aging societies while seeking profit at the same time. This is different from companies taking social responsibility and non-profit organization serving the community in that they attempt to solve social problems through a sustainable business model.
Held under the theme of “technology capabilities of companies and social business strategies,” this symposium was the first to gather representatives from social venture companies, medium-sized enterprises, and major companies at one place to share their experiences in a social business and to discuss future tasks.
The symposium was divided into sessions with three different topics ranging from social business strategies using information technology, a social business and its business model, and social business strategies of major companies.
The symposium started with keynote speeches delivered by Professor HongKyu Lee, RISTI, and Professor Hong-Tak Lim, RISTI, who discussed the role of technology in a social business. It was followed by plenary sessions led by CEOs who are running social businesses such as the Sharing and Technologies Incorporated Project, Simwon Technology, Ecojun Company, Underdogs, and the Farming Fund as well as by representatives from a social responsibility section of CJ management team and the social responsibility council of SK. In the future, these talks will serve as a medium to share their experiences in social businesses and to discuss the role of technology in the business. Some talks touched upon topics such as development of platforms for social innovation, social businesses employing disabled workers, and crowd funding for farming.
The Director of RISTI, Professor HongKyu Lee said, “The symposium will be the first to have people from leading companies in social businesses in Korea in one place.” He added, “This will be a great opportunity for anyone to know what will be the future of social businesses, which were created to solve the social problems caused by capitalism.”
The symposium was sponsored by the Ministry of Trade, Industry, and Energy of Korea.
2015.10.30 View 7489 -
KAIST Invites the World's Top Accelerators to the "Start-up Accelerator Forum"
The Institute for Start-up KAIST hosted a forum on start-up accelerators in cooperation with the KAIST Pangyo Center. More than 100 experts participated in the start-up forum including experts from the world’s top accelerators from Europe and the United States.
Start-up accelerators are companies or institutions that provide support to start-up companies in the early stages to grow into sustainable ventures. Their roles include providing networking opportunities to mentors in technology, marketing, design, business strategy, and potential investors by hosting Demo Days.
The KAIST Start-up Forum is an annual event organized by the Institute for Start-up KAIST to encourage conversations between universities and corporations to promote start-up companies and innovative business strategies.
The forum’s organizers invited Professor Olli Vuola of Aalto University in Finland; Milton B. McColl, the CEO of Gauss Surgical; Kara Shurmanitine, the Director of the Division of Global Partnership at Mass Challenge; and Jimmy Kim, the co-founder of SparkLabs Global Ventures.
2015.10.29 View 3325 -
Two Undergraduate KAIST Students Publish a Book on Health Management
Joonho Suh of the Aerospace Engineering Department and Jiho Suh of the Mechanical Engineering Department are both brothers and undergraduates at KAIST.
The Suh brothers, who are three years apart, have recently published a self-help book in English on staying healthy entitled “A Scientific Approach to Building Muscle: Mass Effect.”
The book introduces techniques to build muscles, adapting them from an engineering concept called "Active Torque Control (ACT)," the management of turning forces imposed on a vehicle. Just as ACT influences the performance of a vehicle, good exercise involves the right degree of body angles and the right direction of body movements to keep the best posture necessary for burning calories and strengthening muscles.
In the book, they also suggest healthy diet plans based on scientific knowledge and data that the writers borrowed from such fields as anatomy, physiology, and motor mechanics to maintain a healthy weight.
Joonho Suh said,
“If we understand the mechanism of how our body works, the chances are high we will have good muscle tone and a balanced diet. We used a great deal of scientific knowledge and turned it into a health management program that can be customized per individual needs.”
The younger brother, Jiho, added,
“In fact, we applied our methods in the book to beginners who took weight training and fitness for one hour a day for one month, we learned that their muscle mass increased by 1-1.5 kg while losing body fat by 2-3 kg.”
The brothers said they planned to publish a Korean language version of the book next year.
The authors of "Mass Effect": Joonho Suh (left) and Jiho Suh (right)
2015.10.26 View 6655 -
KAIST's Graduate School of Culture Technology Celebrates Its Tenth Anniversary
The Graduate School of Culture Technology (GSCT) at KAIST hosted a ceremony and a variety of events to celebrate its tenth anniversary on October 22, 2015, on campus.
Established in 2005 with the support of the Ministry of Culture, Sports and Tourism of the Republic of Korea, GSCT offers an intensive, in-depth education in culture technology, an interdisciplinary field first introduced in Korea by KAIST, which brings arts, humanities, science, and technology together in an academic and research arena.
Over the years, the graduate school has fostered top-notch researchers and professionals who have played a leading role in the development of a Korean culture contents industry that includes movies, broadcasting programs, music, games, and culture events.
After the anniversary ceremony, GSCT held a "Demo Day" to showcase its major research projects. A total of 41 projects were presented under the themes of “Art and Science,” “Human and Humane,” and “Virtual Reality vs Reality.”
In addition, there was a seminar held on GSTC’s ten-year accomplishment and future planning with the school’s Professors Sunghee Lee, Juyong Park, and Juhan Nam; a cultural event for the public called the “Talk Concert,” which included many professionals in culture industry and academia to share ideas and views; and the Homecoming Day for GSTC graduates. So far, the graduate school has produced 295 masters and 34 doctors. About 34% of its graduates are employed in the movie, game, and broadcasting sectors, 33% in the social networking service and Internet industry, and 33% in performing art and exhibition and event.
Dong-Man Lee, the Dean of KAIST's Graduate School of Culture Technology, said,
“We will continue to develop our school to lead the advancement of the Korean culture industry, contributing to the growth of Korean Wave, the popularity of Korean culture, in the global community.”
In the picture below, Dean Lee delivers a speech to celebrate the school’s tenth anniversary.
Soo-Man Lee, the founding chairman of S.M. Entertainment, speaks at the Talk Concert.
Scenes from the Demo Day
2015.10.26 View 7385 -
Epapyrus Donates KAIST Paperless Software
Epapyrus, a solution company for e-documents that was created by a KAIST graduate, donated USD 106,000 worth of paperless software to KAIST on October 20, 2015.
President Steve Kang of KAIST presented a plaque of appreciation to President Jung-Hee Kim of Epapyrus to recognize his donation.
To the Class of 2003 in computer science, President Kim said,
“KAIST has always been supportive of me. Even when I neglected my study to focus on the start-up of my company during college, the university encouraged me to pursue my dream. I was thrilled when I learned that KAIST was looking for an e-paper solution package because I knew I could return what I had received to my alma mater.”
President Kang replied,
“President Kim is indeed one of our proud alumni. He created a company based on an innovative idea, and we are pleased to see his company grow steadily. Certainly, we would not have accomplished all the great things without the generous support of our strong alumni.”
In the picture, President Steve Kang of KAIST (left) holds the appreciation plaque together with President Jung-Hee Kim of Epapyrus.
2015.10.23 View 3410 -
Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award.
Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years.
Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years.
Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells.
Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23 View 9954 -
Mapping the Folding Process of a Single Membrane Protein
KAIST and UCLA scientists were able to observe an individual membrane protein fold and unfold by pulling and releasing magnetically trapped protein molecules.
Proteins are huge molecules containing hundreds to thousands of atoms that adopt a unique three dimensional structure, placing chemical groups in just the right place to catalyze reactions or build cellular structures. How all those atoms manage to find the right location - the so-called folding problem - has fascinated molecular biologists since the first structures were seen in the 1950s. Moreover, folding has important medical implications because most genetic defects cause protein misfolding.
About a third of all proteins float around in the cell membrane where they ensure the right chemicals get in the cell in the right amounts. Membrane proteins also provide key information links between the cell and its environment. Indeed, most drugs target membrane proteins. Nevertheless, the folding of membrane proteins has been particularly difficult to study and has rarely been studied in natural environments, leaving the folding process for a large fraction of the protein universe still largely cloaked in mystery.
In a recent issue of Nature Chemical Biology, published on October 19, 2015, a research team led by Tae-Young Yoon of the Department of Physics at the Korea Advanced Institute of Science and Technology (KAIST) and James U. Bowie of the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), report a new method for manipulating the folding of membrane proteins in a membrane environment using a tool called a magnetic tweezer.
Researchers first attach long DNA handles to the ends of the protein. One handle is attached to a glass surface and the other to a magnetic bead. Using a magnet, they can essentially grab the protein and pull on it, inducing it to unfold. By playing with the bead attached to the protein, they can force the protein to unfold or allow it to refold, and watch all this happening by 3D-tracking of the magnetic bead. With this novel strategy, they were able to quantitatively map the folding energy landscape, the folding kinetic rate, and folding intermediates of a membrane protein in a membrane environment for the first time.
“I have been dreaming about this experiment for a decade. To see it work so well is really gratifying,” said Dr. Bowie.
One of the major surprises in the study was that essentially all the atoms of the protein jump into the correct structure together. The researchers expected that the protein structure would come together in a more piecemeal fashion, with different parts of the structure forming separately, but that was not the case. It is possible that nature evolved such a smooth, highly cooperative folding process to prevent partially folded forms that could get into trouble in the crowded cell membrane. On the other hand, the cooperative folding seen here might not apply to other membrane proteins.
“We need to look at more proteins. The technique developed here may allow us to do just that,” said Dr. Yoon.
The single molecule mechanical manipulation technique could enable detailed folding studies of many other membrane proteins. A major barrier to the study of membrane proteins previously is that the proteins tend to stick together and get tangled up, as computer cords lying at your feet tend to do. With the tweezer technique used in this work, the protein cords are held apart from other cords so they can’t get knotted up. It is hoped that the new approach will open up an important part of the protein universe to scrutiny, including many proteins that become misfolded in disease states.
The title of the research paper is “Mapping the energy landscape for second-stage folding of a single membrane protein” (DOI: 10.1038/nchembio.1939).
Picture: Single-molecule magnetic tweezers that induce mechanical unfolding and refolding of a single membrane protein. Since the force applied is parallel to the biological lipid membrane, the unfolding and refolding processes occur within the membrane.
2015.10.20 View 9259 -
Establishment of System Metabolic Engineering Strategies
Although conventional petrochemical processes have generated chemicals and materials which have been useful to mankind, they have also triggered a variety of environmental problems including climate change and relied too much on nonrenewable natural resources. To ameliorate this, researchers have actively pursued the development of industrial microbial strains around the globe in order to overproduce industrially useful chemicals and materials from microbes using renewable biomass. This discipline is called metabolic engineering.
Thanks to advances in genetic engineering and our knowledge of cellular metabolism, conventional metabolic engineering efforts have succeeded to a certain extent in developing microbial strains that overproduce bioproducts at an industrial level. However, many metabolic engineering projects launched in academic labs do not reach commercial markets due to a failure to fully integrate industrial bioprocesses.
In response to this, Distinguished Professor Sang Yup Lee and Dr. Hyun Uk Kim, both from the Department of Chemical and Biomolecular Engineering at KAIST, have recently suggested ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. Systems metabolic engineering differs from conventional metabolic engineering by incorporating traditional metabolic engineering approaches along with tools of other fields, such as systems biology, synthetic biology, and molecular evolution.
The ten strategies of systems metabolic engineering have been featured in Nature Biotechnology released online in October 2015, which is entitled "Systems strategies for developing industrial microbial strains."
The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects. Specifically, they consist of: 1) project design including economic evaluation of a target bioproduct; 2) selection of host strains to be used for overproduction of a bioproduct; 3) metabolic pathway reconstruction for bioproducts that are not naturally produced in the selected host strains; 4) increasing tolerance of a host strain against the bioproduct; 5) removing negative regulatory circuits in the microbial host limiting overproduction of a bioproduct; 6) rerouting intracellular fluxes to optimize cofactor and precursor availability necessary for the bioproduct formation; 7) diagnosing and optimizing metabolic fluxes towards product formation; 8) diagnosis and optimization of microbial culture conditions including carbon sources; 9) system-wide gene manipulation to further increase the host strain's production performance using high-throughput genome-scale engineering and computational tools; and 10) scale-up fermentation of the developed strain and diagnosis for the reproducibility of the strain's production performance.
These ten strategies were articulated with successful examples of the production of L-arginine using Corynebacterium glutamicum, 1,4-butanediol using Escherichia coli, and L-lysine and bio-nylon using C. glutamicum.
Professor Sang Yup Lee said, "At the moment, the chance of commercializing microbial strains developed in academic labs is very low. The strategies of systems metabolic engineering outlined in this analysis can serve as guidelines when developing industrial microbial strains. We hope that these strategies contribute to improving opportunities to commercialize microbial strains developed in academic labs with drastically reduced costs and efforts, and that a large fraction of petroleum-based processes will be replaced with sustainable bioprocesses."
Lee S. Y. & Kim, H. U. Systems Strategies for Developing Industrial Microbial Strains. Nature Biotechnology (2015).
This work was supported by the Technology Development Program to Solve Climate Change on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) from the Ministry of Science, ICT and Future Planning (MSIP), Korea, and through the National Research Foundation (NRF) of Korea. This work was also supported by the Novo Nordisk Foundation.
Picture: Concept of the Systems Metabolic Engineering Framework
(a) Three major bioprocess stages (b) Considerations in systems metabolic engineering to optimize the whole bioprocess. List of considerations for the strain development and fermentation contribute to improving microbial strain's production performance (red), whereas those for the separation and purification help in reducing overall operation costs by facilitating the downstream process (blue). Some of the considerations can be repeated in the course of systems metabolic engineering.
2015.10.19 View 9817 -
Professor Ki-Jun Jeong Wins the 2015 Dam Yeun Academic Award
The 11th Dam Yeun Academic Award presented by the Korean Society for Biotechnology and Bioengineering (KSBB) to a biologist under 45 years old went to Professor Ki-Jun Jeong of the Chemical and Biomolecular Engineering Department at KAIST.
The award ceremony took place on October 13, 2015, at the annual conference of KSBB held at Songdo Convensia in Incheon City.
Each year KSBB announces the recipient of the award based on the publications by researchers in the last five years at peer-reviewed international journals or KSBB Journal as well as the record of patent registration and technology transfers.
Professor Jeong is recognized for his pioneering research in protein, antibody, cellular engineering, and protein displays and chips.
2015.10.19 View 7753 -
KAIST Agrees to Personnel Exchange with the Ministry of Economic Affairs of the Republic of China
A delegation from the Ministry of Economic Affairs (MOEA) of the Republic of China (ROC) visited KAIST on October 16, 2015.
President Steve Kang of KAIST and Director General Yu-Ping Lien of the Department of Investment Services, MOEA, signed a memorandum of understanding (MOU) on exchanging personnel, recruiting and attracting top talents, and sharing job information.
With the MOU, KAIST and MOEA will develop a mobility program for students in Korea and ROC to help them seek employment opportunities in both nations. Director General Lien hoped that the MOU would bring more of KAIST students in the information technology field to work in ROC.
President Kang responded,
“KAIST has fostered highly talented engineers and researchers across all fields of science and engineering. If these students can have a place in ROC to realize their potential, this certainly could benefit the two nations.”
In the picture from left to right is Director General Yu-Ping Lien of the Department of Investment Services, the Ministry of Economic Affairs of the Republic of China and President Steve Kang of KAIST.
2015.10.17 View 4898