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J. Fraser Stoddart, a Former Visiting Professor at KAIST, Wins the 2016 Nobel Prize in Chemistry
J. Fraser Stoddart, who is Northwestern University’s Board of Trustees Professor of Chemistry and head of the Stoddart Mechanostereochemistry Group, received the 2016 Nobel Prize in Chemistry. He shares it with Professor Jean-Pierre Sauvage of the University of Strasbourg in France and Professor Bernard Feringa of the University of Groningen in the Netherlands.
Professor Stoddart’s relationship with KAIST dates to his term as a visiting professor from 2011 to 2013 at the Environment, Energy, Water and Sustainability (EEWS) Graduate School. The Nobel Committee awarded the prize to Professor Stoddart in recognition of his pioneering work on artificial molecular machines, a.k.a., nanomachines.
A molecular machine is an assembly of a discrete number of molecular components designed to perform machine-like movements as the result of appropriate external stimuli. Like their counterparts in the macroscopic world, molecular machines control mechanical movements and rotations in response to an energy input such as chemical reactions, light, or temperature. The most complex molecular machines, for example, are proteins in cells. Chemists have attempted to imitate these structures for potential applications including smart nanomedicines to track diseases such as cancer cells and deliver drugs to fight them. Other applications include next-generation miniature semiconductor chips, sensors, energy storage, space exploration, and armaments.
In 1991, Professor Stoddart developed artificial molecular machines based on a rotaxane. A rotaxane is a mechanically-interlocked molecular architecture in which a dumbbell-shaped molecule is encircled by a molecular ring called a macrocycle. He presented important research on the production of rotaxanes and demonstrated that a macrocycle could move along or rotate freely around the axle, a dumbbell-shaped molecule.
Professor Stoddart is also an expert in molecular electronics using molecules on the nanoscale as switches in computers and other electronic devices. In 2007, he created a large-scale ultra-dense memory device with reconfigurable molecular switches, the size of white blood cells but capable of storing information. This was a significant achievement towards the development of molecular computers that are much smaller and more powerful compared to today’s silicon-based computers.
KAIST has enjoyed a strong relationship with Professor Stoddart since he served as a visiting professor at the EEWS Graduate School from 2011 to 2013. The graduate school invited him to participate in the Korean government’s science and education program to foster world-class universities in the nation. At KAIST, he taught a course entitled “Nanomachines at the Scale of Molecules.” He also collaborated with Korean researchers on various projects including the publication of a joint research paper, “A Radically Configurable Six-State Compound,” in Science (January 25, 2013) with Professor Jang Wook Choi from the EEWS Graduate School and researchers from the United States, the United Kingdom, and Saudi Arabia.
Two doctors with KAIST ties have links to Professor Stoddart as well. In 2012, Dr. Ali Coskun, who worked with him as a postdoctoral research associate at Northwestern University, became an associate professor at the EEWS Graduate School where he conducts research on secondary batteries and gas storage with artificial molecular machines. Dr. Dong Jun Kim, a KAIST graduate, has been working at the Stoddart Mechanostereochemistry Group as a postdoctoral fellow since 2015.
Picture 1: Synthesis of a Rotaxane Described in the Journal of the American Chemical Society (JACS) in 1991
Picture 2: Professor J. Fraser Stoddart Giving a Presentation at a Workshop Hosted by the EEWS Graduate School at KAIST in 2011
2016.10.13 View 8011 -
Extremely Thin and Highly Flexible Graphene-Based Thermoacoustic Speakers
A joint research team led by Professors Jung-Woo Choi and Byung Jin Cho of the School of Electrical Engineering and Professor Sang Ouk Kim of the Material Science and Engineering Department, all on the faculty of the Korea Advanced Institute of Science and Technology (KAIST), has developed a simpler way to mass-produce ultra-thin graphene thermosacoustic speakers.
Their research results were published online on August 17, 2016 in a journal called Applied Materials & Interfaces. The IEEE Spectrum, a monthly magazine published by the Institute of Electrical and Electronics Engineers, reported on the research on September 9, 2016, in an article titled, “Graphene Enables Flat Speakers for Mobile Audio Systems.” The American Chemical Society also drew attention to the team’s work in its article dated September 7, 2016, “Bringing Graphene Speakers to the Mobile Market.”
Thermoacoustic speakers generate sound waves from temperature fluctuations by rapidly heating and cooling conducting materials. Unlike conventional voice-coil speakers, thermoacoustic speakers do not rely on vibrations to produce sound, and thus do not need bulky acoustic boxes to keep complicated mechanical parts for sound production. They also generate good quality sound in all directions, enabling them to be placed on any surface including curved ones without canceling out sounds generated from opposite sides.
Based on a two-step, template-free fabrication method that involved freeze-drying a solution of graphene oxide flakes and the reduction/doping of oxidized graphene to improve electrical properties, the research team produced a N-doped, three-dimensional (3D), reduced graphene oxide aerogel (N-rGOA) with a porous macroscopic structure that permitted easy modulation for many potential applications.
Using 3D graphene aerogels, the team succeeded in fabricating an array of loudspeakers that were able to withstand over 40 W input power and that showed excellent sound pressure level (SPL), comparable to those of previously reported 2D and 3D graphene loudspeakers.
Choong Sun Kim, the lead author of the research paper and a doctoral student in the School of Electrical Engineering at KAIST, said:
“Thermoacoustic speakers have a higher efficiency when conducting materials have a smaller heat capacity. Nanomaterials such as graphene are an ideal candidate for conductors, but they require a substrate to support their extremely thinness. The substrate’s tendency to lose heat lowers the speakers’ efficiency. Here, we developed 3D graphene aerogels without a substrate by using a simple two-step process. With graphene aerogels, we have fabricated an array of loudspeakers that demonstrated stable performance. This is a practical technology that will enable mass-production of thermosacoustic speakers including on mobile platforms.”
The research paper is entitled “Application of N-Doped Three-Dimensional Reduced Graphene Oxide Aerogel to Thin Film Loudspeaker.” (DOI: 10.1021/acsami.6b03618)
Figure 1: A Thermoacoustic Loudspeaker Consisted of an Array of 16 3D Graphene Aerogels
Figure 2: Two-step Fabrication Process of 3D Reduced Graphene Oxide Aerogel Using Freeze-Drying and Reduction/Doping
Figure 3: X-ray Photoelectron Spectroscopy Graph of the 3D Reduced Graphene Oxide Aerogel and Its Scanning Electron Microscope Image
2016.10.05 View 11883 -
Direct Utilization of Elemental Sulfur for Microporous Polymer Synthesis
Using elemental sulfur as an alternative chemical feedstock, KAIST researchers have produced novel microporous polymers to sift CO2 from methane in natural-gas processing.
Methane, a primary component of natural gas, has emerged recently as an important energy source, largely owing to its abundance and relatively clean nature compared with other fossil fuels. In order to use natural gas as a fuel, however, it must undergo a procedure called “hydrodesulfurization” or “natural gas sweetening” to reduce sulfur-dioxide emissions from combustion of fossil fuels. This process leads to excessive and involuntary production of elemental sulfur. Although sulfur is one of the world’s most versatile and common elements, it has relatively few large-scale applications, mostly for gunpowder and sulfuric acid production.
Thus, the development of synthetic and processing methods to convert sulfur into useful chemicals remains a challenge. A research team led by Professor Ali Coskun from the Graduate School of EEWS (Energy, Environment, Water and Sustainability) at Korea Advanced Institute of Science and Technology (KAIST) has recently introduced a new approach to resolving this problem by employing elemental sulfur directly in the synthesis of microporous polymers for the process of natural-gas sweetening.
Natural gas, containing varying amounts of carbon dioxide (CO2) and hydrogen sulfide (H2S), is generally treated with amine solutions, followed by the regeneration of these solutions at increased temperatures to release captured CO2 and H2S. A two-step separation is involved in removing these gases. The amine solutions first remove H2S, and then CO2 is separated from methane (CH4) with either amine solutions or porous sorbents such as microporous polymers.
Using elemental sulfur and organic linkers, the research team developed a solvent and catalyst-free strategy for the synthesis of ultramicroporous benzothiazole polymers (BTAPs) in quantitative yields. BTAPs were found to be highly porous and showed exceptional physiochemical stability. In-situ chemical impregnation of sulfur within the micropores increased CO2 affinity of the sorbent, while limiting diffusion of CH4. BTAPs, as low-cost, scalable solid-sorbents, showed outstanding CO2 separation ability for flue gas, as well as for natural and landfill gas conditions.
The team noted that: “Each year, millions of tons of elemental sulfur are generated as a by-product of petroleum refining and natural-gas processing, but industries and businesses lacked good ideas for using it. Our research provides a solution: the direct utilization of elemental sulfur into the synthesis of ultramicroporous polymers that can be recycled back into an efficient and sustainable process for CO2 separation. Our novel polymeric materials offer new possibilities for the application of a little-used natural resource, sulfur, to provide a sustainable solution to challenging environmental issues.”
This work was published online in Chem on September 8, 2016 and also highlighted in C&EN (Chemical & Engineering News) by the American Chemical Society (ACS) on September 19, 2016. The research paper was entitled “Direct Utilization of Elemental Sulfur in the Synthesis of Microporous Polymers for Natural Gas Sweetening.” (DOI: 10.1016/j.chempr.2016.08.003)
Figure 1. A Schematic Image of Direct Utilization of Elemental Sulfur
This image shows direct utilization of elemental sulfur in the synthesis of microporous polymers and its gas separation performance.
Figure 2. BTAP’s Breakthrough Experiment under Pre-mixed Gas Conditions
This data presents the breakthrough measurements for CO2-containing binary gas-mixture streams with different feed-gas compositions to investigate the CO2 capture capacity of ultramicroporous benzothiazole polymers (BTAPs) for large-scale applications under simulated conditions of natural and landfill gases.
2016.10.05 View 8364 -
KAIST Ranked the World's Sixth Most Innovative University
KAIST took sixth place in the list of “The World’s Top 100 Most Innovative Universities.” Thomson Reuters released the list on September 28, 2016, which was based on the data compiled by its division of Intellectual Property & Science such as patent filings, number of research papers and their citations, and industry collaboration. American universities took ranks from first to fifth; KAIST was the only non-American university that ranked highest in the list. Stressing the importance of linking basic research with commercializing efforts, Thomson Reuters said, the listed universities were “doing the most to advance science, invent new technologies and help drive the global economy.”
For details, go to the link below:
Reuters Top 100: The World’s Most Innovative Universities-2016
September 28, 2016
http://www.reuters.com/article/amers-reuters-ranking-innovative-univers-idUSL2N1C406D
2016.09.29 View 5733 -
Continuous Roll-Process Technology for Transferring and Packaging Flexible Large-Scale Integrated Circuits
A research team led by Professor Keon Jae Lee from KAIST and by Dr. Jae-Hyun Kim from the Korea Institute of Machinery and Materials (KIMM) has jointly developed a continuous roll-processing technology that transfers and packages flexible large-scale integrated circuits (LSI), the key element in constructing the computer’s brain such as CPU, on plastics to realize flexible electronics.
Professor Lee previously demonstrated the silicon-based flexible LSIs using 0.18 CMOS (complementary metal-oxide semiconductor) process in 2013 (ACS Nano, “In Vivo Silicon-based Flexible Radio Frequency Integrated Circuits Monolithically Encapsulated with Biocompatible Liquid Crystal Polymers”) and presented the work in an invited talk of 2015 International Electron Device Meeting (IEDM), the world’s premier semiconductor forum.
Highly productive roll-processing is considered a core technology for accelerating the commercialization of wearable computers using flexible LSI. However, realizing it has been a difficult challenge not only from the roll-based manufacturing perspective but also for creating roll-based packaging for the interconnection of flexible LSI with flexible displays, batteries, and other peripheral devices.
To overcome these challenges, the research team started fabricating NAND flash memories on a silicon wafer using conventional semiconductor processes, and then removed a sacrificial wafer leaving a top hundreds-nanometer-thick circuit layer. Next, they simultaneously transferred and interconnected the ultrathin device on a flexible substrate through the continuous roll-packaging technology using anisotropic conductive film (ACF). The final silicon-based flexible NAND memory successfully demonstrated stable memory operations and interconnections even under severe bending conditions. This roll-based flexible LSI technology can be potentially utilized to produce flexible application processors (AP), high-density memories, and high-speed communication devices for mass manufacture.
Professor Lee said, “Highly productive roll-process was successfully applied to flexible LSIs to continuously transfer and interconnect them onto plastics. For example, we have confirmed the reliable operation of our flexible NAND memory at the circuit level by programming and reading letters in ASCII codes. Out results may open up new opportunities to integrate silicon-based flexible LSIs on plastics with the ACF packing for roll-based manufacturing.”
Dr. Kim added, “We employed the roll-to-plate ACF packaging, which showed outstanding bonding capability for continuous roll-based transfer and excellent flexibility of interconnecting core and peripheral devices. This can be a key process to the new era of flexible computers combining the already developed flexible displays and batteries.”
The team’s results will be published on the front cover of Advanced Materials (August 31, 2016) in an article entitled “Simultaneous Roll Transfer and Interconnection of Silicon NAND Flash Memory.” (DOI: 10.1002/adma.201602339)
YouTube Link: https://www.youtube.com/watch?v=8OJjAEm27sw
Picture 1: This schematic image shows the flexible silicon NAND flash memory produced by the simultaneous roll-transfer and interconnection process.
Picture 2: The flexible silicon NAND flash memory is attached to a 7 mm diameter glass rod.
2016.09.01 View 10181 -
KAIST Named Asia's Most Innovative University by Thomson Reuters
Thomson Reuters ranked KAIST first among Asia’s top most innovative universities in a list that it released on August 30, 2016. Seventy-five Asian universities received this distinction.
Thomson Reuters created the list to identify those educational institutions that are “doing the most to advance science, invent new technologies, and help drive the global economy.”
The rankings were based on data drawn from each academic institution's research papers and patent filing information as evaluated by the Intellectual Property & Science division of Thomson Reuters.
Thomson Reuters described KAIST as producing "original and influential research" and noted that other organizations cited its patent portfolios as "significant prior art in their own patent applications, a strong indicator that the university has an outsized impact on global research and development."
For details, please go to the link below:
Asia’s Most Innovative Universities
Reuters
August 30, 2016
http://www.reuters.com/article/us-asiapac-reuters-ranking-innovative-un-idUSKCN1152B7#listing
2016.08.31 View 5544 -
Professor Lee to Head the Addis Ababa Institute of Technology
Emeritus Professor In Lee of the Department of Aerospace Engineering at KAIST was appointed to the post of President of the Addis Ababa Institute of Technology (AAiT) in Ethiopia. His term will begin on August 1, 2016 and end on July 31, 2018, which can be extended up to five years.
AAiT is an affiliated institute of Addis Ababa University, a distinguished national university in Ethiopia, and specializes in education and research in engineering and technology. There are currently 5,500 undergraduate and 4,500 graduate students enrolled at the institute.
The Ethiopian government has recognized the importance of science and technology for the future of the country. The government intends to develop AAiT into a distinguished research university similar to KAIST, and thus sought advice from KAIST to recommend an administrator who will head AAiT. Upon recommendation by KAIST President Steve Kang, Professor Lee was appointed.
Professor Lee graduated from Seoul National University with bachelor's and master’s degrees in aeronautical engineering and earned his Ph.D. in aeronautics from Stanford University.
He has served as the President of The Korean Society for Aeronautics and Space Sciences, the Director of the KAIST Satellite Technology Research Center, and a Research Associate at NASA Ames Research Center.
2016.08.03 View 7377 -
KAIST Team Develops Semi-Transparent Solar Cells with Thermal Mirror Capability
A research team led by KAIST and Sungkyunkwan University professors has created semi-transparent perovskite solar cells that demonstrate high-power conversion efficiency and transmit visible light while blocking infrared light, making them great candidates for solar windows.
Modern architects prefer to build exteriors designed with glass mainly from artistic or cost perspectives. Scientists, however, go one step further and see opportunities from its potential ability to harness solar energy. Researchers have thus explored ways to make solar cells transparent or semi-transparent as a substitute material for glass, but this has proven to be a challenging task because solar cells need to absorb sunlight to generate electricity, and when they are transparent, it reduces their energy efficiency.
Typical solar cells today are made of crystalline silicon, but it is difficult to make them translucent. Semi-transparent solar cells under development use, for example, organic or dye-sensitized materials, but compared to crystalline silicon-based cells, their power-conversion efficiencies are relatively low. Perovskites are hybrid organic-inorganic halide-based photovoltaic materials, which are cheap to produce and easy to manufacture. They have recently received much attention as the efficiency of perovskite solar cells has rapidly increased to the level of silicon technologies in the past few years.
Using perovskites, a Korean research team led by Professor Seunghyup Yoo of the Electrical Engineering School at KAIST and Professor Nam-Gyu Park of the Chemical Engineering School at Sungkyunkwan University developed a semi-transparent solar cell that is highly efficient and, additionally, functions very effectively as a thermal-mirror.
The team has developed a top transparent electrode (TTE) that works well with perovskite solar cells. In most cases, a key to success in realizing semi-transparent solar cells is to find a TTE that is compatible with a given photoactive material system, which is also the case for perovskite solar cells. The proposed TTE is based on a multilayer stack consisting of a metal film sandwiched between a high refractive-index (high-index) layer and an interfacial buffer layer. This TTE, placed as a top-most layer, can be prepared without damaging ingredients used in perovskite solar cells. Unlike conventional transparent electrodes focusing only on transmitting visible light, the proposed TTE plays the dual role of passing through visible light while reflecting infrared rays. The semi-transparent solar cells made with the proposed TTEs exhibited average power conversion efficiency as high as 13.3% with 85.5% infrared rejection.
The team believes that if the semi-transparent perovskite solar cells are scaled up for practical applications, they can be used in solar windows for buildings and automobiles, which not only generate electrical energy but also enable the smart heat management for indoor environments, thereby utilizing solar energy more efficiently and effectively.
This result was published as a cover article in the July 20, 2016 issue of Advanced Energy Materials. The research paper is entitled “Empowering Semi-transparent Solar Cells with Thermal-mirror Functionality.” (DOI: 10.1002/aenm.201502466)
The team designed the transparent electrode (TE) stack in three layers: A thin-film of silver (Ag) is placed in between the bottom interfacial layer of molybdenum trioxide (MoO3) and the top high-index dielectric layer of zinc sulfide (ZnS). Such a tri-layer approach has been known as a means to increase the overall visible-light transmittance of metallic thin films via index matching technique, which is essentially the same technique used for anti-reflection coating of glasses except that the present case involves a metallic layer.
Traditionally, when a TE is based on a metal film, such as Ag, the film should be extremely thin, e.g., 7-12 nanometers (nm), to obtain transparency and, accordingly, to transmit visible light. However, the team took a different approach in this research. They made the Ag TE two or three times thicker (12-24 nm) than conventional metal films and, as a result, it reflected more infrared light. The high refractive index of the ZnS layer plays an essential role in keeping the visible light transmittance of the proposed TTE high even with the relatively thick Ag film when its thickness is carefully optimized for maximal destructive interference, leading to low reflectance (and thus high transmittance) within its visible light range.
The team confirmed the semi-transparent perovskite solar cell’s thermal-mirror function through an experiment in which a halogen lamp illuminated an object for five minutes through three mediums: a window of bare glass, automotive tinting film, and the proposed semi-transparent perovskite solar cell. An infrared (IR) camera took thermal images of the object as well as that of each window’s surface. The object’s temperature, when exposed through the glass window, rose to 36.8 Celsius degrees whereas both the tinting film and the cell allowed the object to remain below 27 Celsius degrees. The tinting film absorbs light to block solar energy, so the film’s surface became hot as it was continuously exposed to the lamp light, but the proposed semi-transparent solar cell stayed cool since it rejects solar heat energy by reflection, rather than by absorption. The total solar energy rejection (TSER) of the proposed cell was as high as 89.6%.
Professor Yoo of KAIST said, “The major contributions of this work are to find transparent electrode technology suitable for translucent perovskite cells and to provide a design approach to fully harness the potential it can further deliver as a heat mirror in addition to its main role as an electrode. The present work can be further fine-tuned to include colored solar cells and to incorporate flexible or rollable form factors, as they will allow for greater design freedom and thus offer more opportunities for them to be integrated into real-world objects and structures such as cars, buildings, and houses.”
The lead authors are Hoyeon Kim and Jaewon Ha, both Ph.D. candidates in the School of Electrical Engineering at KAIST, and Hui-Seon Kim, a student in the School of Chemical Engineering at Sungkyunkwan University. This research was supported mainly by the Climate Change Research Hub Program of KAIST.
Picture 1: Semi-transparent Perovskite Solar Cell
This picture shows a prototype of a semi-transparent perovskite solar cell with thermal-mirror functionality.
Picture 2: A Heat Rejection Performance Comparison Experiment
This picture presents thermal images taken by an infrared camera for comparing the heat rejection performance of bare glass, automotive tinting film, and a semi-transparent perovskite solar cell after being illuminated by a halogen lamp for five minutes.
2016.08.02 View 11471 -
KAIST Develops Transparent Oxide Thin-Film Transistors
With the advent of the Internet of Things (IoT) era, strong demand has grown for wearable and transparent displays that can be applied to various fields such as augmented reality (AR) and skin-like thin flexible devices. However, previous flexible transparent displays have posed real challenges to overcome, which are, among others, poor transparency and low electrical performance. To improve the transparency and performance, past research efforts have tried to use inorganic-based electronics, but the fundamental thermal instabilities of plastic substrates have hampered the high temperature process, an essential step necessary for the fabrication of high performance electronic devices.
As a solution to this problem, a research team led by Professors Keon Jae Lee and Sang-Hee Ko Park of the Department of Materials Science and Engineering at the KAIST has developed ultrathin and transparent oxide thin-film transistors (TFT) for an active-matrix backplane of a flexible display by using the inorganic-based laser lift-off (ILLO) method. Professor Lee’s team previously demonstrated the ILLO technology for energy-harvesting (Advanced Materials, February 12, 2014) and flexible memory (Advanced Materials, September 8, 2014) devices.
The research team fabricated a high-performance oxide TFT array on top of a sacrificial laser-reactive substrate. After laser irradiation from the backside of the substrate, only the oxide TFT arrays were separated from the sacrificial substrate as a result of reaction between laser and laser-reactive layer, and then subsequently transferred onto ultrathin plastics ( thickness). Finally, the transferred ultrathin-oxide driving circuit for the flexible display was attached conformally to the surface of human skin to demonstrate the possibility of the wearable application. The attached oxide TFTs showed high optical transparency of 83% and mobility of even under several cycles of severe bending tests.
Professor Lee said, “By using our ILLO process, the technological barriers for high performance transparent flexible displays have been overcome at a relatively low cost by removing expensive polyimide substrates. Moreover, the high-quality oxide semiconductor can be easily transferred onto skin-like or any flexible substrate for wearable application.”
These research results, entitled “Skin-Like Oxide Thin-Film Transistors for Transparent Displays,”
(http://onlinelibrary.wiley.com/doi/10.1002/adfm.201601296/abstract) were the lead article published in the July 2016 online issue of Wiley’s Advanced Functional Materials.
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References
[1] Advanced Materials, February 12, 2014, Highly-efficient, Flexible Piezoelectric PZT Thin Film Nanogenerator on Plastic Substrates
(http://onlinelibrary.wiley.com/doi/10.1002/adma.201305659/abstract)
[2] Advanced Materials, September 8, 2014, Flexible Crossbar-structured Resistive Memory Arrays on Plastic Substartes via Inorganic-based Laser Lift-off
(http://onlinelibrary.wiley.com/doi/10.1002/adma.201402472/abstract)
Picture 1: A Schamatic Image of Ultrathin, Flexible, and Transparent Oxide Thin-film Transistors
This image shows ultrathin, flexible, and transparent oxide thin-film transistors produced via the ILLO process.
Picture 2: Application of Uultrathin, Flexible, and Transparent Oxide Thin-film Transistors
This picture shows ultrathin, flexible, and transparent oxide thin-film transistors attached to a jumper sleeve and human skin.
2016.08.01 View 11625 -
Professor Seyun Kim Identifies a Neuron Signal Controlling Molecule
A research team led by Professor Seyun Kim of the Department of Biological Sciences at KAIST has identified inositol pyrophosphates as the molecule that strongly controls neuron signaling via synaptotagmin.
Professors Tae-Young Yoon of Yonsei University’s Y-IBS and Sung-Hyun Kim of Kyung Hee University’s Department of Biomedical Science also joined the team.
The results were published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on June 30, 2016.
This interdisciplinary research project was conducted by six research teams from four different countries and covered a wide scope of academic fields, from neurobiology to super resolution optic imaging.
Inositol pyrophosphates such as 5-diphosphoinositol pentakisphos-phate (5-IP7), which naturally occur in corns and beans, are essential metabolites in the body. In particular, inositol hexakisphosphate (IP6) has anti-cancer properties and is thought to have an important role in cell signaling.
Inositol pentakisphosphate (IP7) differs from IP6 by having an additional phosphate group, which was first discovered 20 years ago. IP7 has recently been identified as playing a key role in diabetes and obesity.
Psychopathy and neurodegenerative diseases are known to result from the disrupted balance of inositol pyrophosphates. However, the role and the mechanism of action of IP7 in brain neurons and nerve transmission remained unknown.
Professor Kim’s team has worked on inositol pyrophosphates for several years and discovered that very small quantities of IP7 control cell-signaling transduction. Professor Yoon of Yonsei University identified IP7 as a much stronger inhibitor of neuron signaling compared to IP6. In particular, IP7 directly suppresses synaptotagmin, one of the key proteins in neuron signaling. Moreover, Professor Kim of Kyung Hee University observed IP7 inhibition in sea horse neurons.
Together, the joint research team identified inositol pyrophosphates as the key switch metabolite of brain-signaling transduction.
The researchers hope that future research on synaptotagmin and IP7 will reveal the mechanism of neuron-signal transduction and thus enable the treatment of neurological disorders.
These research findings were the result of cooperation of various science and technology institutes: KAIST, Yonsei-IBS (Institute for Basic Science), Kyung Hee University, Sungkyunkwan University, KIST, University of Zurich in Switzerland, and Albert-Ludwigs-University Freiburg in Germany.
Schematic Image of Controlling the Synaptic Exocytotic Pathway by 5-IP7 , Helping the Understanding of the Signaling Mechanisms of Inositol Pyrophosphates
2016.07.21 View 10538 -
'The 2016 Top 100 Research Projects in Korea'
The Ministry of Science, ICT and Future Planning (MSIP) of Korea recently released a list of the 2016 Top 100 Research Projects in Korea. The list included the work of KAIST Professors Dong-Ho Cho of the School of Electrical Engineering, Jeung Ku Kang of the Graduate School of Energy, Environment, Water and Sustainability (EEWS), and Sang Yup Lee of the Chemical and Biomolecular Engineering Department.
Experts from academia, universities, and industries selected the 100 research projects, among 620 projects recommended by various government offices, in consideration of their contribution to the growth of science and technology in the nation.
Professor Cho conducts research on the development of 5G mobile communication systems based on the pattern polarization beam-division multiple access method.
Professor Kang works on the production of highly efficient energy materials and equipment by controlling them at the electron and atomic level.
Professor Lee focuses on the creation of strategies to produce important chemicals through a biological approach, i.e., microorganisms, which will help develop the means to mitigate climate change.
The MISP will publish a book that describes in detail each research project and will distribute copies of it to the National Assembly of Korea, libraries, and other public organizations.
For more information on the list, please go to www.ntis.go.kr.
Pictured from left to right are Professors Dong-Ho Cho, Jeung Ku Kang, and Sang Yup Lee.
2016.07.21 View 4655 -
ICISTS Hosts the International Interdisciplinary Conference
A KAIST student organization, The International Conference for the Integration of Science, Technology and Society (ICISTS), will host ICISTS 2016 at the Hotel ICC in Daejeon from 3 to 7 August with the participation of around 300 Korean and international students.
ICISTS was first established in 2005 to provide an annual platform for delegates and speakers to discuss the integration and the convergence of science, technology, and society regardless of their academic backgrounds.
This year’s conference, with the theme of “Beyond the Center,” emphasizes the ways in which technological advancements can change central organizations in areas such as financial technology, healthcare, and global governance.
The keynote speakers include Dennis Hong, a developer of the first automobile for the blind and a professor of the Mechanical and Aerospace Engineering Department at UCLA, Dor Konforty, a founder and a CEO of SNS platform Synereo, and Marzena Rostek, a professor of Economics at the University of Wisconsin-Madison.
Other notable speakers include: Gi-Jung Jung, Head of the National Fusion Research Institute; Janos Barberis, Founder of FinTech HK; Tae-Hoon Kim, CEO and Founder of Rainist; Gulrez Shah Azhar, Assistant Policy Analyst at RAND Corporation; Thomas Concannon, Senior Policy Researcher at RAND Corporation; Leah Vriesman, Professor at the School of Public Health, UCLA; and Bjorn Cumps, Professor of Management Practice at Vlerick Business School in Belgium.
The conference consists of keynote speeches, panel discussions, open talks, experience sessions, team project presentations, a culture night, and a beer party, at which all participants will be encouraged to interact with speakers and delegates and to discuss the topics of their interest.
Han-Kyul Jung, ICISTS’s Head of Public Relations, said, “This conference will not only allow the delegates to understand the trends of future technology, but also be an opportunity for KAIST students to form valuable contacts with students from around the world.”
For more information, please go to www.icists.org.
2016.07.20 View 7402