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KAIST and JAIT Sign MOU
KAIST and JAIT (Jeonbuk Institute of Automotive Technology) signed a MOU for the training and development of future automobile technology.
JAIT is the domestic front runner in automobile research and the MOU will allow KAIST to participate with JAIT on research and development of automobile technology.
Research on future vehicle technology, transportation system using electric transport system, cooperation in education, research and development, and international business, and knowledge transfer are all part of the MOU.
2012.11.29 View 7569 -
Liver Damage Mechanism of Hepatitis C Proven
KAIST researchers found mechanics behind a Hepatitis C virus, thereby taking a step closer to the development of a cure for Hepatitis C.
Professor Choi Chul Hui (Department of Biological and Brain Engineering) and Professor Shin Eui Chul (Graduate School of Medical Sciences) proved, for the first time in the world, the mechanism behind liver damage of a patient with Hepatitis C.
It is anticipated that this discovery will allow for the development of a Hepatitis C cure that has no side effects and little Liver damage.
Hepatitis C is an immune response of the body to the Hepatitis C virus and causes liver irritation.
Around 170million people are infected with Hepatitis C worldwide including 1% of the Korean population. Once infected, most cases turn into chronic cases and may lead to liver cancer.
However it was impossible to infect Hepatitis C within a test tube cell environment until 2005 and up till then Chimpanzees were used to study the virus which proved to be a huge barrier to research.
The research team used cells infected with Hepatitis C virus and found out that the virus works by increasing the destruction of cells by the TNF-a protein responsible for the cell’s immune response.
In addition the protein structure of the virus that causes this reaction was successfully found.
Conventionally the Hepatitis C medication focused on the suppressing the growth of the virus and therefore had many side effects.
The experimental results allow new medication aimed at suppressing the actual mechanism of liver damage to be discovered.
The result was selected as the cover dissertation of the September Edition of the Hepatolog magazine.
2012.09.11 View 12801
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Systems biology demystifies the resistance mechanism of targeted cancer medication
Korean researchers have found the fundamental resistance mechanism of the MEK inhibitor, a recently highlighted chemotherapy method, laying the foundation for future research on overcoming cancer drug resistance and improving cancer survival rates. This research is meaningful because it was conducted through systems biology, a fusion of IT and biotechnology.
The research was conducted by Professor Gwang hyun Cho’s team from the Department of Biology at KAIST and was supported by the Ministry of Education, Science and Technology and the National Research Foundation of Korea.
The research was published as the cover paper for the June edition of the Journal of Molecular Cell Biology (Title: The cross regulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor).
Targeted anticancer medication targets certain molecules in the signaling pathway of the tumor cell and not only has fewer side effects than pre-existing anticancer medication, but also has high clinical efficacy. The technology also allows the creation of personalized medication and has been widely praised by scientists worldwide.
However, resistances to the targeted medication have often been found before or during the clinical stage, eventually causing the medications to fail to reach the drug development stage. Moreover, even if the drug is effective, the survival rate is low and the redevelopment rate is high.
An active pathway in most tumor cells is the ERK (Extracellular signal-regulated kinases) signaling pathway. This pathway is especially important in the development of skin cancer or thyroid cancer, which are developed by the mutation of the BRAF gene inside the path. In these cases, the MEK (Extracellular signal-regulated kinases) inhibitor is an effective treatment because it targets the pathway itself. However, the built-up resistance to the inhibitor commonly leads to the redevelopment of cancer.
Professor Cho’s research team used large scale computer simulations to analyze the fundamental resistance mechanism of the MEK inhibitor and used molecular cell biological experiments as well as bio-imaging* techniques to verify the results.
* Bio-imaging: Checking biological phenomena at the cellular and molecular levels using imagery
The research team used different mutational variables, which revealed that the use of the MEK inhibitor reduced the transmission of the ERK signal but led to the activation of another signaling pathway (the PI3K signaling pathway), reducing the effectiveness of the medication. Professor Cho’s team also found that this response originated from the complex interaction between the signaling matter as well as the feedback network structure, suggesting that the mix of the MEK inhibitor with other drugs could improve the effects of the targeted anticancer medication.
Professor Cho stated that this research was the first of its kind to examine the drug resistivity against the MEK inhibitor at the systematic dimension and showed how the effects of drugs on the signaling pathways of cells could be predicted using computer simulation. It also showed how basic research on signaling networks can be applied to clinical drug use, successfully suggesting a new research platform on overcoming resistance to targeting medication using its fundamental mechanism.
2012.07.06 View 11953
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The output of terahertz waves enhanced by KAIST team
KAIST researchers have greatly improved the output of terahertz waves, the blue ocean of the optics world. This technology is expected to be applied to portable X-ray cameras, small bio-diagnostic systems, and in many other devices.
Professor Ki-Hun Jeong"s research team from the Department of Bio and Brain Engineering used optical nano-antenna technology to increase the output of terahertz waves by three times.
Terahertz waves are electromagnetic waves with frequencies between 100GHz to 30THz. They are produced when a femtosecond (10^-15 s) pulse laser is shone on a semiconductor substrate with photoconduction antennas, causing a photocurrent pulse of one picosecond (10^-12 s). Their long wavelengths, in comparison to visible light and infrared rays, give terahertz waves a high penetration power with less energy than X-rays, making them less harmful to humans.
These qualities allow us to see through objects, just as X-rays do, but because terahertz waves absorb certain frequencies, we can detect hidden explosives or drugs, which was not possible with X-rays. We can even identify fake drugs. Furthermore, using the spectral information, we can analyze a material"s innate qualities without chemical processing, making it possible to identify skin diseases without harming the body. However, the output was not sufficient to be used in biosensors and other applications.
Prof. Jeong"s team added optical nano-antennas, made from gold nano-rods, in between the photoconduction antennas and optimized the structure. This resulted in nanoplasmonic resonance in the photoconduction substrate, increasing the degree of integration of the photocurrent pulse and resulting in a three times larger output.
Hence, it is not only possible to see through objects more clearly, but it is also possible to analyze components without a biopsy.
Professor Jeong explained, "This technology, coupled with the miniaturization of terahertz devices, can be applied to endoscopes to detect early epithelial cancer" and that he will focus on creating and commercializing these biosensor systems.
This research was published in the March issue of the international nanotechnology journal ACS Nano and was funded by the Korea Evaluation Institute of Industrial Technology and the National Research Foundation of Korea.
Figure: Mimetic diagram of a THz generator with nano-antennas
2012.04.29 View 12824 -
Seeing Inside Cells with Fiber Optics
Professor Jiho Park’s research team was successful in receiving minute optical signals from inside the cell using optical nano fibers.
Through the invention of this technology, we can now look inside cells in high resolution without the use of equipment such as endoscopes that damage cells. We will be able to study the biological phenomena within cells, and thus cure diseases more effectively.
Recently, ultra high resolution microscopes have been used to analyze incubated cells. However, because of the need for a very complex and large system, it had been impossible to monitor cells in the less transparent areas of the body in real time.
The research team created the wire with a semiconductor created with tin oxides to be only 100 nanometers in diameter (1nanometer= 1/1billion meters).
The nanowire is connected to the end of the optical fiber, and the light that comes through the optical fiber is transmitted to particular spots in the cell, and the optical signals from the cell are retrieved back from the cell as well
Together with this, based on the fact that nanowires do not damage cells, the research team covered the end of the wire with a photo reactive material and entered this into the cell. They were able to check that the material reacted to light and entered the cell when they transmitted light
Accordingly, this showed the possibilities of the use of this technology as a method of treatment to effectively transfer the medication into the cells.
Prof. Jiho Park stated that “in this research, we only used cells incubated outside the human body, but soon we will use this technology to stimulate and control cells within the body in a minute scale” as well as that “soon, we will be able to study the biological phenomena inside a cell to study diseases and apply this to cure them more effectively”.
This research result has been published in the online publication of ‘Nature Nanotechnology’ on December 18.
This study was done through the cooperation of various schools. Besides Prof. Jiho Park, Prof. Seungman Yang from the Biochemistry department, and Doctor Chuljoon Huh from KAIST, Prof. Yeonho Choi from Biomedical Science department of Korea University, Professor Peidon Yang and Doctor Ruoxue Yan from UC Berkeley’s chemistry department, and Luke Lee from UC Berkeley’s bioengineering department participated in the project.
2012.01.31 View 10019
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KAIST has developed a powerless and wireless keyboard that can be folded and easily carried around.
The KAIST Institute for Information Technology Convergence (KIITC) has developed the next generation keyboard that does not need power and wires.
The powerless/wireless keyboard developed by KIITC is flexible, foldable, portable, and compact, making the possession of keyboard easier and more convenient.
The idea of this technology was derived from "Idea Contest for Future Device" opened by KIITC in 2007, and Future Device Team (Team Leader: Dr. Sungkwan Jung) of KIITC embodied the idea and developed full-flexible powerless/wireless keyboard by using the passive Radio Frequency Identification (RFID) technology to support the convenient data input for daily mobile life.
Through the technology, KAIST expects to realize ubiquitous computing and communication environment, open a new market for foldable keyboards, and secure the competitiveness of mobile devices industries in the world market.
KIITC has also successfully transferred the technology of powerless/wireless keyboard to Hanyang Demitech for commercialization.
2010.08.12 View 12888 -
Board Chairman Chung Makes First Visit to Building Named After Him
Moon-Soul Chung, chairman of the KAIST board of trustees, visited the building built with his donation on Monday (Oct. 19) for the first time since he made the deed of gift eight years ago, university authorities said on Monday (Oct. 19).
In 2000, Chung, founder and former CEO of Mirae Corp, manufacturer of semiconductor testing equipment, announced retirement and handed over the presidency of his company to one of his managing directors. One year later in 2001, he donated 30 billion won, then equivalent to $30 million, to KAIST. It was by then the largest amount given by a single donor.
The major part of his donation went to constructing a building for the newly-established Department of Bio and Brain Engineering, and it was named after him. However, Chung did not attend the ground-breaking and dedication ceremonies, saying that he would not enter the building until KAIST achieved a breakthrough technology which can inject a hope to Koreans.
On his first visit to the building, he was briefed on the major research outcomes of the department over the past seven years, which were highlighted by the recent invention of an apparatus for measuring perfusion rate of legs. A KAIST team headed by Prof. Chul-Hee Choi invented a light leakage prevention unit including a light emitting device for radiating light having a certain wavelength onto a living body injected with Indocyanine Green (ICG).
According to Prof. Choi, the invention relates to an apparatus for measuring the perfusion rate of legs. The invention also includes a light leakage prevention housing formed to prevent transmission of external light.
Chung expressing satisfaction with the achievements and encouraged professors, researchers and students working at the Moon-Soul Chung Building.
2009.10.20 View 14353 -
Sungil Chung listed in Who's Who following last year
Sungil Chung listed in Who’s Who following last year
Sungil Chung, senior researcher of KAIST Satellite Technology Research Center (STRC), is listed in the international biographical dictionary Marquis Who"s Who’s Who’s Who in the America Edition 2007 following last year. He is also listed in the first edition of Who’s Who of Emerging Leaders.
Ph.D. Chung majored in Electrohydrodynamics (EHD) at Texas A&M University and worked at NASA’s Goddard Space Flight Center for a research in the field of aerospace vehicle-related thermal control. He has worked at KAIST STRC as senior researcher from September this year.
He has won an Innovation and Creativity Prize Paper Award from the U.S. Institute of Electrical and Electronics Engineers (IEEE) in 2004.
2006.11.16 View 17054