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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers.
*Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes.
Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions).
Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease.
Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease.
Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases.
However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself.
Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases.
The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases.
It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems.
The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30 View 11778 -
Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11747
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KAIST College of Business ranks no.1 in Asia for executive education
KAIST College of Business ranked 28th in the world and 1st in Asia in the UK Financial Times (FT) 2012 Executive Education open ranking, making it the only school in Korea to be included.
The FT ranking selects the world’s top 65 business graduate schools based on executive education course design, teaching methods & materials, faculty, new skills & learning, quality of participants, and several other criteria. Last year, the KAIST executive education program ranked 29th in the world and 2nd in Asia. This year, it surpassed China’s CEIBS to rank 1st in Asia and has now been included in the ranking for three consecutive years.
Looking at the individual criteria, KAIST ranked highly in course preparation (11th), international location (11th), facilities (12th), and follow-up (5th) and saw increases in aims achieved (31st) and course design (29th).
KAIST attributed its success to the differentiation and specialization of education courses based on position, industry, and enterprise. KAIST College of Business operates an integrative course that fuses business management with science & technology, information media, medicine and innovation. The school runs both a chief and junior executive program to cater to different positional needs and provides specialized lectures that consider a company’s industry and size.
The ‘international location’ criteria saw a huge leap from 23rd to 11th due to the use of both long term and short term overseas exchange programs. The ‘Global Leader’ course created in 2011 is taught only in English and allows students to study abroad in a partner school in the second semester. The college’s knowhow in the MBA program also achieved recognition with high rankings in new skills & learning (18th) as well as in teaching methods & materials (24th).
College of Business President Lee Byung Tae said that the school’s success was achieved through a specialized curriculum that considers the market and explained that the ranking reflects the school’s competitiveness. He also said that KAIST will continue to provide the best educational services appropriate for KAIST’s outstanding reputation.
In the overall ranking, Swiss IMD was ranked number 1, followed by the Harvard Business School. In Asia, China’s CEIBS (29th), Singapore’s Aalto University (42nd), and the National University of Singapore Business School (64th) followed suit.
2012.05.17 View 9146
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Biomimetic reflective display technology developed
Professor Shin Jung Hoon
The bright colors of a rainbow or a peacock are produced by the reflection and interference of light in transparent periodic structures, producing what is called a structural color. These colors are very bright and change according to the viewing angle. On the other hand, the wings of a morpho-butterfly also have structural colors but are predominantly blue over a wide range of angles. This is because the unique structure of the morpho-butterfly’s wings contains both order and chaos.
Professor Shin Jung Hoon’s team from the Department of Physics and the Graduate School of Nanoscience and Technology at KAIST produced a display that mimics the structure of the morpho-butterfly’s wings using glass beads.
This research successfully produced a reflective display (one that reflects external light to project images), which could be used to make very bright displays with low energy consumption. This technology can also be used to make anti-counterfeit bills, as well as coating materials for mobile phones and wallets.
The structure of the morpho-butterfly’s wings seems to be in periodic order at the 1-micrometer level, but contains disorder at the 100-nanometer level. So far, no one had succeeded in reproducing a structure with both order and disorder at the nanometer level.
Professor Shin’s team randomly aligned differently sized glass beads of a few hundred nanometers to create chaos and placed a thin periodic film on top of it using the semiconductor deposition method, thereby creating the morpho-butterfly-like structure over a large area.
This new development produced better color and brightness than the morpho-butterfly wing and even exhibited less color change according to angle. The team sealed the film in thin plastic, which helped to maintain the superior properties whilst making it more firm and paper-like.
Professor Shin emphasized that the results were an exemplary success in the field of biomimetics and that structural colors could have other applications in sensors and fashion, for example.
The results were first introduced on May 3rd in Nature as one of the Research Highlights and will be published in the online version of the material science magazine, Advanced Materials.
This research was jointly conducted by Professor Shin Jung Hoon (Department of Physics / Graduate School of Nanoscience and Technology at KAIST), Professor Park NamKyoo (Department of Electrical and Computer Engineering at Seoul National University), and Samsung Advanced Institute of Technology. The funding was provided by the National Research Foundation of Korea and the Ministry of Education, Science and Technology as part of the World Class University (WCU) project.
Figure 2. The biomimetic film can express many different colors
Figure 3. The biomimetic diplay and a morpho-butterfly
2012.05.07 View 13440 -
The output of terahertz waves enhanced by KAIST team
KAIST researchers have greatly improved the output of terahertz waves, the blue ocean of the optics world. This technology is expected to be applied to portable X-ray cameras, small bio-diagnostic systems, and in many other devices.
Professor Ki-Hun Jeong"s research team from the Department of Bio and Brain Engineering used optical nano-antenna technology to increase the output of terahertz waves by three times.
Terahertz waves are electromagnetic waves with frequencies between 100GHz to 30THz. They are produced when a femtosecond (10^-15 s) pulse laser is shone on a semiconductor substrate with photoconduction antennas, causing a photocurrent pulse of one picosecond (10^-12 s). Their long wavelengths, in comparison to visible light and infrared rays, give terahertz waves a high penetration power with less energy than X-rays, making them less harmful to humans.
These qualities allow us to see through objects, just as X-rays do, but because terahertz waves absorb certain frequencies, we can detect hidden explosives or drugs, which was not possible with X-rays. We can even identify fake drugs. Furthermore, using the spectral information, we can analyze a material"s innate qualities without chemical processing, making it possible to identify skin diseases without harming the body. However, the output was not sufficient to be used in biosensors and other applications.
Prof. Jeong"s team added optical nano-antennas, made from gold nano-rods, in between the photoconduction antennas and optimized the structure. This resulted in nanoplasmonic resonance in the photoconduction substrate, increasing the degree of integration of the photocurrent pulse and resulting in a three times larger output.
Hence, it is not only possible to see through objects more clearly, but it is also possible to analyze components without a biopsy.
Professor Jeong explained, "This technology, coupled with the miniaturization of terahertz devices, can be applied to endoscopes to detect early epithelial cancer" and that he will focus on creating and commercializing these biosensor systems.
This research was published in the March issue of the international nanotechnology journal ACS Nano and was funded by the Korea Evaluation Institute of Industrial Technology and the National Research Foundation of Korea.
Figure: Mimetic diagram of a THz generator with nano-antennas
2012.04.29 View 11305 -
International workshop on healthcare technology to be held on campus, April 24, 2012
KAIST and the KTH Royal Institute of Technology (KTH), Sweden, host a joint workshop on healthcare technologies on Tuesday, April 24, at the LG Semicon Hall (N24).
Open to the public, the workshop will proceed with presentations and discussions by participants from both institutions. Presentation topics and speakers are as follows:
“Applied medical engineering, innovation from clinical problems” by Professor Lars-Åke Brodin, Dean of School of Technology and Health, KTH
“ICT in healthcare” by Professor Björn-Erik Erlandsson, School of Technology and Health, KTH
“Department of environmental physiology, human research in extreme environments” by Researcher Mikael Grönkvist, School of Technology and Health, KTH
“Brain function imaging using high-resolution MRI technology” by Professor Hyun Wook Park, Department of Electrical Engineering, KAIST
“Bioinstrumentation for healthcare and physical human robot interactions” by Professor Jung Kim, Division of Mechanical Engineering, KAIST
“A portable high-resolution near-infrared spectroscopy system” by Professor Hyeon-Min Bae, Department of Electrical Engineering, KAIST
“Lab-on-a-chip technologies for integrative bioengineering” by Professor Je-Kyun Park, Department of Bio and Brain Engineering, KAIST
“The cytoskeleton in cancer and regulation by oncogenic signaling” by Professor David M. Helfman, Department of Biological Sciences, KAIST
Professor Chang Dong Yoo, Associate Vice President of Office of Special Projects and Institutional Relations at KAIST, who organized the workshop, says “Aging population and health issues are driving the demand for more sophisticated medical devices, procedures, and most importantly, qualified scientists and engineers specialized in health-related fields. This joint workshop will be a great chance to share new ideas and develop joint research between two leading research-oriented universities in two countries.”
Partially supported by LG Ericsson in Korea, the workshop is funded largely by the generous donation, made last June by a Swedish couple, to KAIST scholar exchange program.
The couple (Rune Jonasson and Kerstin Jonasson) donated 70 million krona (about 11.8 billion Korean won) to KTH last year and requested that some portion of the sum be used for a scholar exchange program with KAIST. The wife of the couple, Kerstin Jonasson, participated in the Korean War as a nurse, and upon her wish for further development in Korea’s science and technology, KAIST and KTH decided to use the donation for research in the field of healthcare and for a post-doc researcher exchange program.
KTH is a world-class university of Sweden and has produced numerous researchers for private enterprises, like Ericsson, and venture businesses. Since 1988, KTH offers a top notch program for information technology; the School of Information and Communication Technology is located in the Kista district, a vibrant cluster of information and communications technology industries in Sweden, and has taken on the crucial role of supplying personnel to the Kista Science Park as well as to academic-industrial cooperation.
For any inquiries, please contact the International Relations Team at +82-42-350-2441 (email: jungillee@kaist.ac.kr).
2012.04.21 View 10658 -
Attosecond pulses measure ultrafast photoionization processes by Laser Focus World, April 12, 2012
Laser Focus World, a monthly magazine published since 1965 that covers news and business developments on laser, photonics, and optoelectronics technologies, applications, and markets, released a news article on the recent research result by Professor Chang-Hee Nam from the Department of Physics. For the article, please follow the link below:
http://www.laserfocusworld.com/articles/2012/04/kaist-attosecond
2012.04.13 View 7533
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10 Technolgies to Change the World in 2012: The Future Technology Global Agenda Council
The Future Technology Global Agenda Council which is under the World Economy Forum and which KAIST’s biochemical engineering department’s Prof. Sang Yeob Lee is the head of, chose the 10 new technologies that will change the world in year 2012.
The ten technologies include: IT, synthetic biology and metabolic engineering, Green Revolution 2.0, material construction nanotechnology, systematic biology and the simulation technology of biological systems, the technology to use CO2 as a natural resource, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology.
The technologies were chosen on the basis of the opinions various science, industry, and government specialists and is deemed to have high potential to change the world in the near future.
The Future Technology Global Agenda Council will choose ten new technologies yearly starting this year in order to solve the problems the world now faces.
The informatics systems that was ranked 1st place, sifts only the data necessary for decision making out of the overflowing amount of data. Much interest has been spurred at the Davos forum.
The synthetic biology and metabolic engineering chosen is expected to play an important role in creating new medicines and producing chemical substances and materials from reusable resources.
Biomass has also been chosen as one of the top ten most important technologies as it was seen to be necessary to lead the second Green Revolution in order to stably provide food for the increasing population and to create bio refineries.
Nanomaterials structured at the molecular level are expected to help us solve problems regarding energy, food, and resources.
Systematic biology and computer modeling is gaining importance in availing humans to construct efficient remedies, materials, and processes while causing minimum effects on the environment, resource reserves, and other people.
The technology to convert CO2, which is considered a problem all over the world, into a useful resource is also gaining the spotlight
Together with such technologies, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology are also considered the top ten technologies to change the world.
Prof. Lee said, “Many new discoveries are being made due to the accelerating rate of technological advancements. Many of the technologies that the council has found are sustainable and important for the construction of our future.”
2012.04.04 View 10306
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Inexpensive Separation Method of Graphene Developed
The problem with commercializing graphene that is synthesized onto metals over a wide area is that it can not be separated from the metal. However, a groundbreaking separation technology which is both cheap and environment friendly has been developed.
Prof. Taek soo Kim and Prof. Byung Jin Cho"s research teams have conducted this research under the support of the Global Frontier program and Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research results have been posted on the online news flash of Nano Letters on februrary 29th. (Thesis title: Direct Measurement of Adhesion Energy of Monolayer Graphene As-Grown on Copper and Its Application to Renewable Transfer Process)
The research has generated exact results on the interfacial adhesive energy of graphene and its surface material for the first time. Through this, the catalyst metal are no longer to be used just once, but will be used for an infinite number of times, thereby being ecofriendly and efficient.
Wide area graphine synthesized onto the catalyst meatal are used in various ways such as for display and for solar cells. There has been much research going on in this field. However, in order to use this wide area graphene, the graphene must be removed from the catalyst metal without damage.
Until now, the metal had been melted away through the use of chemical substances in order to separate the graphene. However, this method has been very problematic. The metal can not be reused, the costs are very high, much harmful wastes were created in the process of melting the metals, and the process was very complicated.
The research teams of Professors Taek Su Kim and Byung Jin Cho measured the interfacial adhesive energy of the synthesized graphene and learned that it could be easily removed.
Also, the mechanically removed graphene was successfully used in creating molecular electronic devices directly. This has thus innovatively shortened the graphene manufacturing process. Also, it has been confirmed that the metalic board can be reused multiple times after the graphene is removed. A new, ecofriendly and cost friendly method of graphene manufacturing has been paved.
Through this discovery, it is expected that graphene will become easier to manufacture and that the period til the commercialization date of graphene will therefore be greatly reduced
Prof. Cho stated " This reserach has much academical meaning significance in that it has successfully defined the surfacial adhesive energy between the graphene and its catalyst material and it should receive much attention in that it solved the largest technical problem involved in the production of graphene.
2012.04.04 View 12642
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New Era for Measuring Ultra Fast Phenomena: Atto Science Era
Domestic researchers successfully measured the exact status of the rapidly changing Helium atom using an atto second pulse. Thanks to this discovery, many ultrafast phenomena in nature can now be precisely measured. This will lead to an opening of a new "Atto Science" era.
Prof. Nam Chang Hee led this research team and Ph.d Kim Kyung Taek and Prof. Choi Nak Ryul also participated in this research. They have conducted the research under the support of the Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research result was published in the prestigious journal "Physical Review Letters" on March 2nd. (Title: Amplitude and Phase Reconstruction of Electron Wave Packets for Probing Ultrafast Photoionization Dynamics)
Prof. Nam Chang Hee"s research team used atto second pulse to measure the ultrafast photoionization.
His team used atto second X-ray pulse and femto second laser pulse to photoionize Helium atoms, and measure the wave speed of the produced electron to closely investigate the ultrafast photoionization process.
Atom"s photoionization measurement using an atto second pulse was possible using the research team"s high-energy femto second laser and high-performance photo ion measurement device. This research team succeeded in producing the shortest 60 atto second pulse in the world using high-harmonic waves.
The research team used high-power femto second laser to produce atto second high-harmonic pulse from argon gas, used this to photoionize Helium atoms, and measured the ultrafast photoionization of the atoms.
Prof. Nam Chang Hee said, "This research precisely measured the exact status of rapidly changing Helium atoms. I am planning to research on measuring the ultrafast phenomena inside atoms and molecules and controlling the status of the atoms and molecules based on the research result."
2012.04.04 View 9618
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Education 3.0: Student Centered, Innovative Education
Education 3.0 is a teaching method development program aiming to raise the quality and efficiency of education through innovating the existing one-sided professor-student lecture approach.
Students will be able to study regardless of the time and space restrictions thanks to the IT-based curriculum, and will be able to conduct independent studies. Also, the lectures and contents will become internationalized through sharing them with other advanced universities. The lectures will take on an integrated format where students and professors will be discussing things together.
KAIST will be testing this program on the three courses of calculus, general chemistry, and freshmen design, and will further expand the use of this program.
Participants have been chosen from the freshmen this year, and 201 students have signed up for calculus and 163 for general chemistry, showing great enthusiasm on the new program. 48 students have been selected for each course out of the volunteers.
Class will take on both the form of an online and offline lecture.
Students must first log on to the KLMS(KAIST Learning Management System) and then review the lecture video, slides, multimedia, online lab, outside video resources, and other digital content prepared by the professors, and learn according to one’s own pace. Questions can be asked online, and assignments are also to be submitted online.
The offline lectures will take place at least once a week, and students are to discuss and question the material together and form groups to solve problems on their own. The professor and TAs are to interact with the students in the method seen as appropriate for the course.
For this Education 3.0 program, KAIST has installed a lecture system, video tracking system, A/V system, circular desks, glass boards, and other state-of-the-art facilities into a classroom in the Creative Learning Building. The KLMS(KAIST Learning Management System) which will serve as a learning platform has also been developed.
The reason why KAIST has been spending so much resources on education innovation has been that KAIST can not produce the talented personnel required by the future society with the current ‘one-way lecture’.
Tae-Eog Lee, the head of the Education 3.0 program said, “The current lecture method targeted for mass education can not created the leaders for the future society and companies. The lecture and education paradigm must shift in the science and engineering fields for the production of talented individuals with problem-solving abilities and creativity.”
He also stated, “The KAIST education 3.0 program is a student focused education method where the students who are the receivers of the education are the focus of the education, as well as a future-oriented method where the lectures are to become discussion-focused.”
While all the top notch universities are conducting education innovations, MIT has proposed an MITX program where it even gives students certificates for some classes just for listening to classes online and passing the test.
MIT is being evaluated as the leader of higher level education since through this everyone around the world will receive the chance to receive advanced education.
2012.04.04 View 8864
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Creation of Synthetic Antibodies: Professor Hak Seong Kim
Synthetics antibodies which can replace antibodies from humans used as ingredients of medicines have been developed. It can increase the costs to 1/100 of the current costs and is much easier to develop. It is expected that the development period will be shortened from 10 years to 5.
Prof. Hak Seong Kim from the Biology department of KAIST conducted a joint research with Prof. Dong Seob Kim to reconstruct proteins and has succeeded.
The synthetic antibody displays much strength in terms of its productivity, structural formation, and bonding capability, and is thus regarded as an ideal protein. It can replace the antigens that are currently in use. It is expected that Korea will therefore be able to lead the world market for protein medicines which is a 192trillion won industry.
The original antibody has been used for not only treating diseases, but also for various other applications in the fields of medical sciences and biology. However, it is produced through a very complex process involving the incubation of animal cells, and is therefore very expensive. Also, most antibodies are already patented by more developed countries, so a high royalty fee must be paid.
Because of this, many countries including Korea has been concentrating on developing biosimilars copying the antibody medicines for which the patents have already expired. This causes Korea to be behind in the development of antibody protein pharmaceuticals.
Prof. Kim’s research team has focused on the face that the protein existing in some eels are not antibodies but functions as one, and has been successful in developing a synthetic antibody.
The synthetic antibody can be mass produced from the colon bacillus, which allows it to be produced at 1/100 the original cost. It is in a module structure which allows the structuring of the antibody into the desired structure, enabling it to be developed into a protein-based medicine within 5 years.
Together with this, the coherence with the important antigens can be easily controlled, thus allowing for highly effective treatments, less side-effects, high security regarding heat and pH, and the immunogen levels being negligeable. This suggests a very high rate of the antibody being converted into a protein based medication.
The synthetic antibody technology has been tested as a sample for the cure for lung diseases and rheumatism and has been proven to be appropriate. Animal testing will be conducted soon.
Prof Kim said “The original antibodies had a small area allowing the bonding with antibodies, creating barriers for raising bonding strength and structuring. The newly created antibody carries only the strengths and will become a new protein based medicine purely created by Korean technology to replace the antibodies currently used in medications.”
Furthermore, he added that, “The synthesized antibody structuring and designing technology will be widely used in the areas of detecting, diagnosing, and analyzing diseases.”
At the same time, this research result has been published in the Feb 10th issue of the PNAS, and has been supported by the future promising pioneer business program held by the Ministry of Education and Technology.
2012.04.04 View 10252