communication
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Prof. Song Chong received the IEEE William R. Bennett Prize Paper Award
The IEEE (Institute of Electrical and Electronics Engineers) Communications Society (ComSoc), a renowned global network of professionals with a common interest in advancing communications technologies, has announced the winner of the 2013 William R. Bennett Prize in the field of communications networking. The prize was given to a Korean research team led by Song Chong, Professor of Electrical Engineering at KAIST and Injong Rhee, Professor of Computer Science at North Carolina State University. In addition, Dr. Minsu Shin, Dr. Seongik Hong, and Dr. Seong Joon Kim of Samsung Electronics Co., Ltd. as well as Professor Kyunghan Lee from Ulsan National Institute of Science and Technology were recognized for their contribution.
The William R. Bennett Prize for communications networking has been awarded each year since 1994 in recognition of the best paper published in any journal financially sponsored or co-sponsored by ComSoc in the previous three calendar years. Only one paper per year is selected based on its quality, originality, scientific citation index, and peer reviews. Among the previous award winners are Robert Gallager of MIT, and Steven Low of the California Institute of Technology, and Kang G. Shin of the University of Michigan.
The Korean research team’s paper, On the Levy-Walk Nature of Human Mobility, was published in the June 2011 issue of IEEE/ACM Transactions on Networking, a bimonthly journal co-sponsored by the IEEE ComSoc, the IEEE Computer Society, and the Association for Computing Machinery (ACM) with its Special Interest Group on Data Communications (SIGCOMM).
In the paper, the research team proposed a new statistical model to effectively analyze the pattern of individual human mobility in daily life. The team handed out GPS (global positioning system) devices to 100 participants residing in five different university campuses in Korea and the US and collected data on their movements for 226 days. The mobility pattern obtained from the experiment predicted accurately how the participants actually moved around during their routines. Since publication, the paper has been cited by other papers approximately 350 times.
The team’s research results will apply to many fields such as the prevention and control of epidemics, the design of efficient communications networks, and the development of urban and transportation system.
The research team received the award on June 10th at the 2013 IEEE International Conference on Communications (ICC) held in Budapest, Hungary, from June 9-13, 2013.
Professor Song Chong
2013.07.06 View 12133 -
A KAIST research team developed in vivo flexible large scale integrated circuits
Daejeon, Republic of Korea, May 6th, 2013–-A team led by Professor Keon Jae Lee from the Department of Materials Science and Engineering at KAIST has developed in vivo silicon-based flexible large scale integrated circuits (LSI) for bio-medical wireless communication.
Silicon-based semiconductors have played significant roles in signal processing, nerve stimulation, memory storage, and wireless communication in implantable electronics. However, the rigid and bulky LSI chips have limited uses in in vivo devices due to incongruent contact with the curvilinear surfaces of human organs. Especially, artificial retinas recently approved by the Food and Drug Administration (refer to the press release of FDA"s artificial retina approval) require extremely flexible and slim LSI to incorporate it within the cramped area of the human eye.
Although several research teams have fabricated flexible integrated circuits (ICs, tens of interconnected transistors) on plastics, their inaccurate nano-scale alignment on plastics has restricted the demonstration of flexible nano-transistors and their large scale interconnection for in vivo LSI applications such as main process unit (MPU), high density memory and wireless communication. Professor Lee"s team previously demonstrated fully functional flexible memory using ultrathin silicon membranes (Nano Letters, Flexible Memristive Memory Array on Plastic Substrates), however, its integration level and transistor size (over micron scale) have limited functional applications for flexible consumer electronics.
Professor Keon Jae Lee"s team fabricated radio frequency integrated circuits (RFICs) interconnected with thousand nano-transistors on silicon wafer by state-of-the-art CMOS process, and then they removed the entire bottom substrate except top 100 nm active circuit layer by wet chemical etching. The flexible RF switches for wireless communication were monolithically encapsulated with biocompatible liquid crystal polymers (LCPs) for in vivo bio-medical applications. Finally, they implanted the LCP encapsulated RFICs into live rats to demonstrate the stable operation of flexible devices under in vivo circumstances.
Professor Lee said, "This work could provide an approach to flexible LSI for an ideal artificial retina system and other bio-medical devices. Moreover, the result represents an exciting technology with the strong potential to realize fully flexible consumer electronics such as application processor (AP) for mobile operating system, high-capacity memory, and wireless communication in the near future."
This result was published in the May online issue of the American Chemical Society"s journal, ACS Nano (In vivo Flexible RFICs Monolithically Encapsulated with LCP). They are currently engaged in commercializing efforts of roll-to-roll printing of flexible LSI on large area plastic substrates.
Movie at Youtube Link: Fabrication process for flexible LSI for flexible display, wearable computer and artificial retina for in vivo biomedical application
http://www.youtube.com/watch?v=5PpbM7m2PPs&feature=youtu.be
Applications of in Vivo Flexible Large Scale Integrated Circuits
Top: In vivo flexible large scale integrated circuits (LSI); Bottom: Schematic of roll-to-roll printing of flexible LSI on large area plastics.
2013.06.09 View 12424 -
Neurotransmitter protein structure and operation principle identified
Professor Tae-Young Yoon
- Real-time measurement of structural change of bio-membrane fusion protein
- A new clue to degenerative brain diseases research
KAIST Physics Department’s Professor Tae-Young Yoon has successfully identified the hidden structure and operation mechanism of the SNARE protein, which has a central role in transporting neurotransmitters between neurons, using magnetic nanotweezers. SNARE protein’s cell membrane fusion function is closely related to degenerative brain diseases or neurological disorders such as Alzheimer’s. Hence, this research may provide a clue to the disease’s prevention and treatment.
Neurotransmission occurs when vesicles containing neurotransmitters fuse with cell membranes in neuron synapses. The SNARE protein is a cell-membrane fusion protein with a core role of releasing neurotransmitters. The academia speculated the SNARE protein would regulate the exchange of neurotransmitters, but its precise function and structure has been unknown. Professor Yoon’s research team developed an experimental technique using nanotweezers to measure physical changes to nanometer level by pulling and releasing each protein with force of 1 pN (piconewton). The research identified the existence of hidden SNARE protein"s intermediate structure. The process of withstanding and maintaining repulsive forces between bio-membranes in the hidden intermediate structure of SNARE to regulate the exchange of neurotransmitters has also been identified.
Professor Yoon’s research team developed an experimental technique using magnetic nanotweezers to measure physical changes of proteins to nanometer level by pulling and releasing each protein with force of 1 pN. The research identified the existence of hidden SNARE protein"s intermediate structure and its formation. The process of withstanding and maintaining repulsive forces between bio-membranes in the hidden intermediate structure of SNARE to regulate the exchange of neurotransmitters has also been discovered.
Professor Yoon said, “Ground breaking research results have been produced. A simple experimental technique of applying the smallest possible forces to proteins (with tweezers) to see their hidden structure and formation process can produce the same result as real observation has been developed.” He continued, “This technique will be very important in researching biological object with physical experimental technique. It will be a vital foundation to consilient research of different academia in the future.”
This research was a joint project of Physics Department’s Professor Tae-Young Yoon, KAIST, and Biomedical Engineering Institute’s Professor Yeon-Kyun Shin at KIST. KAIST Physics Department’s Professor Yong-Hoon Cho, Ph.D. candidate Do-Yong Lee and KIAS Computational Sciences Department’s Professor Chang-Bong Hyun participated. The research was published on Nature Communications on April 16th.
a) Neurotransmission occurs when vesicles containing neurotransmitters fuse with cell membranes in neuron synapses. A SNARE protein is a cell-membrane fusion protein with a core role of releasing neurotransmitters.
b) A schematic diagram using magnetic nanotweezers to measure protein structure changes on molecular level. The nanotweezers exert an exquisite pull and release of each protein with a force of 1 pN to measure physical changes to nanometer level in real-time to observe the hidden intermediate structure and operation principles of bio-membrane fusion protein.
2013.05.25 View 8626 -
The new era of personalized cancer diagnosis and treatment
Professor Tae-Young Yoon
- Succeeded in observing carcinogenic protein at the molecular level
- “Paved the way to customized cancer treatment through accurate analysis of carcinogenic protein”
The joint KAIST research team of Professor Tae Young Yoon of the Department of Physics and Professor Won Do Huh of the Department of Biological Sciences have developed the technology to monitor characteristics of carcinogenic protein in cancer tissue – for the first time in the world.
The technology makes it possible to analyse the mechanism of cancer development through a small amount of carcinogenic protein from a cancer patient. Therefore, a personalised approach to diagnosis and treatment using the knowledge of the specific mechanism of cancer development in the patient may be possible in the future.
Until recently, modern medicine could only speculate on the cause of cancer through statistics. Although developed countries, such as the United States, are known to use a large sequencing technology that analyses the patient’s DNA, identification of the interactions between proteins responsible for causing cancer remained an unanswered question for a long time in medicine.
Firstly, Professor Yoon’s research team has developed a fluorescent microscope that can observe even a single molecule. Then, the “Immunoprecipitation method”, a technology to extract a specific protein exploiting the high affinity between antigens and antibodies was developed. Using this technology and the microscope, “Real-Time Single Molecule co-Immunoprecipitation Method” was created. In this way, the team succeeded in observing the interactions between carcinogenic and other proteins at a molecular level, in real time.
To validate the developed technology, the team investigated Ras, a carcinogenic protein; its mutation statistically is known to cause around 30% of cancers.
The experimental results confirmed that 30-50% of Ras protein was expressed in mouse tumour and human cancer cells. In normal cells, less than 5% of Ras protein was expressed. Thus, the experiment showed that unusual increase in activation of Ras protein induces cancer.
The increase in the ratio of active Ras protein can be inferred from existing research data but the measurement of specific numerical data has never been done before.
The team suggested a new molecular level diagnosis technique of identifying the progress of cancer in patients through measuring the percentage of activated carcinogenic protein in cancer tissue.
Professor Yoon Tae-young said, “This newly developed technology does not require a separate procedure of protein expression or refining, hence the existing proteins in real biological tissues or cancer cells can be observed directly.” He also said, “Since carcinogenic protein can be analyzed accurately, it has opened up the path to customized cancer treatment in the future.”
“Since the observation is possible on a molecular level, the technology confers the advantage that researchers can carry out various examinations on a small sample of the cancer patient.” He added, “The clinical trial will start in December 2012 and in a few years customized cancer diagnosis and treatment will be possible.”
Meanwhile, the research has been published in Nature Communications (February 19). Many researchers from various fields have participated, regardless of the differences in their speciality, and successfully produced interdisciplinary research. Professor Tae Young Yoon of the Department of Physics and Professors Dae Sik Lim and Won Do Huh of Biological Sciences at KAIST, and Professor Chang Bong Hyun of Computational Science of KIAS contributed to developing the technique.
Figure 1: Schematic diagram of observed interactions at the molecular level in real time using fluorescent microscope. The carcinogenic protein from a mouse tumour is fixed on the microchip, and its molecular characteristics are observed live.
Figure 2: Molecular interaction data using a molecular level fluorescent microscope. A signal in the form of spike is shown when two proteins combine. This is monitored live using an Electron Multiplying Charge Coupled Device (EMCCD). It shows signal results in bright dots.
An organism has an immune system as a defence mechanism to foreign intruders. The immune system is activated when unwanted pathogens or foreign protein are in the body. Antibodies form in recognition of the specific antigen to protect itself. Organisms evolved to form antibodies with high specificity to a certain antigen. Antibodies only react to its complementary antigens. The field of molecular biology uses the affinity between antigens and antibodies to extract specific proteins; a technology called immunoprecipitation. Even in a mixture of many proteins, the protein sought can be extracted using antibodies. Thus immunoprecipitation is widely used to detect pathogens or to extract specific proteins.
Technology co-IP is a well-known example that uses immunoprecipitation. The research on interactions between proteins uses co-IP in general. The basis of fixing the antigen on the antibody to extract antigen protein is the same as immunoprecipitation. Then, researchers inject and observe its reaction with the partner protein to observe the interactions and precipitate the antibodies. If the reaction occurs, the partner protein will be found with the antibodies in the precipitations. If not, then the partner protein will not be found. This shows that the two proteins interact.
However, the traditional co-IP can be used to infer the interactions between the two proteins although the information of the dynamics on how the reaction occurs is lost. To overcome these shortcomings, the Real-Time Single Molecule co-IP Method enables observation on individual protein level in real time. Therefore, the significance of the new technique is in making observation of interactions more direct and quantitative.
Additional Figure 1: Comparison between Conventional co-IP and Real-Time Single Molecule co-IP
2013.04.01 View 17209 -
KAIST International Students Organize KAIST ONE Program
International Students at KAIST are running a program called “KAIST ONE” (Overseas Networking Exchange) in order to promote an active exchange between students and to present their cultures.
Originally an international cultural activity at the ICU (then the Information and Communications University) in 2007, the program changed its name to “KAIST ONE” and was continued after the merging of the university with KAIST. Students of about 40 different countries have participated to date, and each annual event attracts more than 150 students.
Over 700 international students from 70 different countries around the world spontaneously organize and manage the KAIST ONE program, which is run five times this semester, every other Thursday from 7p.m. to 9p.m. at the KAIST International Center.
The 11th of last month and the 1st of this month witnessed an enthusiastic response from about 150 participants who joined the Columbian and the Saudi Arabian students in introducing their cultures, presenting traditional cultural performances, and sharing traditional foods.
The next in line are Danish, Ugandan, and Cameroonian students who are set to have their turns on this month’s 15th, 29th, and next month’s 6th, respectively.
Also notable is the active attention and support from foreign embassies such as the participation of Tunisian, Brazilian, Pakistani, Azerbaijani, Thai, and German ambassadors in the program since last year to provide food and introductory guides to cultures.
The director of this year’s program, Karim Charfi (Tunisian, 3rd year Electrical Engineering) said, “During the selection stage of each semester, everyone competes for the chance to present their country,” and “KAIST ONE has established itself as a unique and exotic cultural event at KAIST since it networks about 40 of the relatively less known countries such as Uganda, Cameroon, Tunisia, and Chile and the people with diverse cultures.”
The supervisor of the program, Chang Dong Yoo of the Office of Special Projects and Institutional Relations said, “KAIST ONE is an opportunity for international students to acquaint people with their cultures, and it is also a site of cultural exchange and of building friendships among KAIST students and international students,” and “we plan to extend the event such that not only the KAIST members but also the local residents can join in.”
The program welcomes KAIST students as well as the general public.
2012.12.21 View 7338 -
2012 Intellectual Property Rights Award Ceremony Held
The 2012 Intellectual Property Rights Award Ceremony was held at Seoul KAIST Campus.
Recipients of the award included former congressmen Kim Young Sun and Lee Jeong Hyuk, and Kim Boo Kyung researcher at Electronics and Telecommunications Research Institute also representing Vooz Ltd. that created the character POOCA.
The Intellectual Property Rights Award is given to an individual or a group that succeeded in utilizing, protecting, creating, and establishment of its foundation including patent, copyright, and brand. Intellectual Property Rights is viewed as of importance for future national competitiveness.
The Award is organized by the Korea Patent Attorneys Association, the Korea Association of Intellectual Property Services, and KAIST and are respectively core institutions in the training of Intellectual Property Rights Experts and the creation, utilization, and the protection of intellectual property.
In addition the Award is also co-organized by the KAIST Graduate School of Intellectual Property Rights (established in cooperation with KAIST and the Korean Intellectual Property Office) and the total 20 million Won of prize money is funded by Korea Institute of Intellectual Strategy and Kim Ok Lan Foundation.
The Award Ceremony was held with a special lecture by the recipients.
It was stressed that the evaluation process was carried out with that the decision is a silent message to the society and is also a type of market signal.
Director Ko Gi Seok (Presidential Council on Intellectual Property) revealed that the candidates’ impact on the strength of national intellectual property rights was thoroughly scrutinized.
In the criteria of Creation of Intellectual Property, ETRI received the award in recognition of the institution’s successful patenting and commercializing of products of Korean R&D.
ETRI created a total of 251 International Patents in cooperation with ITU, ISO, IEE, etc. and also participated in a total of 9 International Standard Patent Pool, showing its active Intellectual Property management.
Such efforts ranked ETRI 1st in the United States Patent Evaluation performed by the US Patent Board in 2011 out of 237 institutions.
In addition Recipient of the Intellectual Property Utilization criteria, VOOZ ltd.’s Kim Boo Kyung promised the free use of their character POOCA in ETRI’s automated Korean-English translator. Researcher Kim Boo Kyung was rewarded with the award in recognition of his contribution to the domestic economy and realization of the commercialization of a copy right through licensing.
Former congressman Kim Young Son received an Award in the Foundation criteria in recognition of his efforts in the establishment of the Presidential Council on Intellectual Property and the Basic Blueprints for the Intellectual Property Law.
Former congressman Lee Jeong Hyuk received the same award in recognition of standardization and streamlining Intellectual Property Rights Policies. His realization and pursuit of the establishment of a balanced growth based on law for the competitiveness of businesses was the driving force behind his accomplishments.
2012.10.16 View 10231
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Information Sharing Webzine "You'reKA"
KAIST will be opening “You’reKA” to improve communication between staff members and between KAIST family members. “You’reKA” will primarily deal with school policies, research successes, news of KAIST family members, opinions, and other on, off campus news.
“You’reKA” is a shortened form of “You are KAIST” and is a homonym of ‘Eureka’ an expression used for scientific discovery and is supposed to instill pride as KAISTians.
The webzine is set to be opened in January of this year and will showcase 5 menus: “We Ask KAIST the Way”, “KAIST Report”, “Issue Briefing”, “Opinion” and “You”.
“We Ask KAIST the Way” introduces messages from the President and Vice President of KAIST and is a corner where honest opinions regarding the university’s vision and leadership are shared. It will be run as a Q&A corner that includes major publications and comments along with interviews, external experts, and staff members.
Under the “KAIST Report” menu, there will be ‘KAIST Today’ section where up to date research and experiment successes are posted, and a ‘KAIST Yard’ where various event information and news of KAIST members are shared.
“Issue Briefing” will introduce an overall assessment of various university management policies and issues and provide a complete scan of information. “Opinion” will allow visitors to the webzine to read up on various perspectives and comments from Professors and experts on Science and Technology.
The “You” menu will introduce various stories, activities, and expertise of KAIST staff members and their families.
“You’reKA” is expected to bring the campus closer together and provide an agora of sorts where ideas can be exchanged and bring down the differences between each member of KAIST.
2012.01.31 View 7264
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 8827
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TEAK: New Multimedia Site kaistube.org Offers Lectures on English
For those wanting an experience of KAIST from an entirely new perspective, there is some good news. The new multimedia website, kaistube.org is available for browsing with better and newer content.
The website, kaistube.org, is a “Creative media in English by the students of KAIST” and was created with aims to introduce university life from the perspective of the very components that makes KAIST, KAIST; its students.
The website features photos the students took and short films they created about KAIST and of KAIST. It can be said that kaistube.org is fast becoming the creative hub and outlet for students at KAIST to express their creative personalities. Students at KAIST or anywhere else for that matter should not be restricted to just academic activities, which make kaistube.org so meaningful.
One great service that can be found at kaistube.org is the TEAK (Teaching English at KAIST). TEAK is a weekly show created and hosted by Visiting Professors Tim Thompson and Don Rikley and serves to provide education in presentation skills and writing skills in English. Season one focused on academic writing and Season two will focus on academic speaking and presentation skills.
The importance of clear communications skills via presentations or writing format in English has become ever important in this era of globalization. The lectures provided for at kaistube.org is a great resource and guide that will aid not only the family members at KAIST, but to any and all non-KAISTians who wish to strengthen their grasp on the English language.
The podcasts can be downloaded onto the computer for transfer to a portable music player, like the iPod or the iPhone, and can be even downloaded from the iTunes.
2011.04.02 View 9198
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New Korean Robot Responds to Non-Verbal Commands
An online newspaper covering the latest headline news based on MS Windows, Internet and technology trends, Infopackets, posted an article on the research result of KAIST researchers: a robot prototype developed, which is able to respond to human’s non verbal communication.
Robots now can read human gestures and react to their subtle commands by “designing the robot’s main system to mimic the actions of a human in the same manner in which human brains function.” For details of the article, please click the link:
http://www.infopackets.com/news/technology/science/2011/20110125_new_korean_robot_responds_to_non_verbal_commands.htm
2011.01.26 View 8479
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Former Minister of Information & Communications Dae-Je Jin donated to KAIST.
From left to right: Yong-Hoo Lee, Dean of Information Science & Technology College, KAIST; Gang-Seok Lee, Vice President of Skylake Incuvest, Inc.; Dae-Je Jin, Former Minister of Information & Communications; Byung-Kyu Choi, Provost of KAIST; and Dae-Joon Joo, Vice President of Planning & Budget, KAIST.
Mr. Dae-Je Jin, who had served as the Minister of Information & Communications, South Korea, gave away about 100,000 USD to KAIST and hoped that his donation would be used for the development of information and technology industry in the nation.
Mr. Jin, widely known as one of the reputable business leaders in the IT industry, was also once the president of Samsung Electronics, a leading global supplier of electronic products and goods. Currently, he runs a private equity investor called, Skylake Incuvest, Inc., which invests and incubates innovative information, communications, and technology companies.
“The real growth engine for our nation to become an economic powerhouse on a global stage has been the highly trained people who shore up our industry. Universities including KAIST have played an excellent role in providing our nation with such outstanding researchers and engineers. I will continue to support for KAIST"s mission as a leading research university in science and technology in Korea and the world,” said Mr. Jin.
KAIST said that his donation would be used for the support of its IT researches.
2010.08.27 View 10304 -
Indoor Localization System for Mobile Devices Developed by KAIST Research Team
The technology will be available to smart phone users around the world through Goole Apps Store.
The wireless fidelity (WiFi)-based indoor localization can be installed on smart phones for commercialization, a technology developed by a research team at KAIST. The KAIST research team, led by Professor Dong-Soo Han, Department of Computer Science and Engineering, explained that the technology offers smart phone users, e.g., Google’s Android phone and Apple’ iPhone, a unique way to recognize their location through WiFi Open Radio Map. WiFi Open Radio Map is built with WiFi Location Fingerprint that contains wireless local area network (LAN)’s signal strength and wireless access points (AP) number, and with location information.
Through using the Map, WiFi-based indoor localization recognizes the location of smart phones and sends the location information to the phones. Since the technology uses WiFi signal information only to recognize the whereabouts of phones, it can be widely used in the future, without installing extra machines and equipment for detection, for a complicated, large indoor environment, where the Global Positioning System (GPS) is not available.
Currently, Professor Han has established WiFi Open Radio Map inside and outside of a few buildings at KAIST and developed several location based application services to perform a beta testing. He plans to open and distribute the technology to smart phone users through Google and Apple Apps Store in early 2010. Collaborations with major smart phone makers such as SK Telecom, Korea Telecom, and Samsung as well as outdoor/indoor localization manufactures and suppliers will also be sought, according to Professor Han.
Professor Han is invited to an international conference, Eighth Annual IEEE International Conference on Pervasive Computing and Communications, slated for early April 2010, in recognition of his work. At the conference, he will give a presentation on WiFi based indoor localization technology and conduct its demo version.
2010.02.10 View 10980