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Visualizing Chemical Reaction on Bimetal Surfaces
Catalysts are the result of many chemists searching to unravel the beauty of molecules and the mystery of chemical reactions. Professor Jeong Young Park from the Department of Chemistry, whose research focuses on catalytic chemical reactions, is no exception. His research team recently made breakthroughs in addressing long-standing questions for understanding reaction mechanisms on bimetal catalysts.
During the studies reported in Science Advances, following a publication in Nature Communications this month, Professor Park’s research team identified that the formation of metal–oxide interfaces is the key factor responsible for the synergistic catalytic effect in bimetal catalysts. The team confirmed this fundamental reaction mechanism through in situ imaging of reaction conditions. This is the first visualization of bimetal surfaces under reaction conditions, signifying the role of metal–oxide interfaces in heterogeneous catalysis.
Bimetallic materials have outstanding catalytic performance, which opens a new pathway for controlling electronic structures and binding energy in catalysts. Despite considerable research on various catalytic reaction efficiencies, there are yet unanswered questions on the underlying principles behind the improved performance. Even more, it was very hard to figure out what led to the efficiency because the structure, chemical composition, and oxidation state of bimetallic materials change according to reaction conditions.
Recently, some research groups suggested that oxide–metal interfacial sites formed by the surface segregation of bimetallic nanoparticles might be responsible for the increased catalytic performance. However, they failed to present any definitive evidence illustrating the physical nature or the fundamental role of the oxide–metal interfaces leading to the improved performance.
To specifically address this challenge, the research team carried out in situ observations of structural modulation on platinum–nickel bimetal catalysts under carbon monoxide oxidation conditions with ambient pressure scanning tunneling microscopy and ambient pressure X-ray photoelectron spectroscopy.
The team observed that platinum–nickel bimetal catalysts exhibited a variety of different structures depending on the gas conditions. Under ultrahigh vacuum conditions, the surface exhibited a platinum skin layer on the platinum–nickel alloyed surface, selective nickel segregation followed by the formation of nickel oxide clusters using oxygen gas, and finally the coexistence of nickel oxide clusters on the platinum skin during carbon monoxide oxidation. The research team found that the formation of interfacial platinum–nickel oxide nanostructures is responsible for a highly efficient step in the carbon monoxide oxidation reaction.
These findings illustrate that the enhancement of the catalytic activity on the bimetallic catalyst surface originates from the thermodynamically efficient reaction pathways at the metal–metal oxide interface, which demonstrates a straightforward process for the strong metal–support interaction effect. The formation of these interfacial metal–metal oxide nanostructures increases catalytic activity while providing a thermodynamically efficient reaction pathway by lowering the heat of the reactions on the surface. [J. Kim et al. Adsorbate-driven reactive interfacial Pt-NiO1-x nanostructure formation on the Pt3Ni(111) alloy surface, Science Advances (DOI: 10.1126/sciadv.aat3151 ]
Professor Park said that one way to monitor catalysts is to detect hot electrons associated with energy dissipation and conversion processes during surface reactions. His team led the real-time detection of hot electrons generated on bimetallic PtCo nanoparticles during exothermic hydrogen oxidation. The team successfully clarified the origin of the synergistic catalytic activity of PtCo nanoparticles with corresponding chemicurrent values.
By estimating the chemicurrent yield, the research team conclude that the catalytic properties of the bimetallic nanoparticles are strongly governed by the oxide–metal interface, which facilitates hot electron transfer. [H. Lee et al. Boosting hot electron flux and catalytic activity at metal–oxide interfaces of PtCo bimetallic nanoparticles, Nature Comm, 9, 2235 (2018)].
Professor Park explained, “We feel that the precise measurement of hot electrons on catalysts gives insight into the mechanism for heterogeneous catalysis, which can help with the smart design of highly reactive materials. The control of catalytic activity via electronic engineering of catalysts is a promising prospect that may open the door to the new field of combining catalysis with electronics, called “catalytronics.” He added that the study also establishes a strategy for improving catalytic activity for catalytic reactions in industrial chemical reactors.
Professors Park and Yousung Jung from the Department of Chemical and Biomolecular Engineering and the Graduate School of EEWS conducted this research in collaboration with Professor Bongjin Mun from the Department of Physics at GIST.
Figure 1. Evolution of surface structures of PtNi bimetal surfaces under various ambient conditions.
Figure 2. Formation of Pt-CoO interface leads to the catalytic enhancement of PtCo bimetal catalysts.
2018.07.25 View 8782 -
It's Time to 3D Sketch with Air Scaffolding
People often use their hands when describing an object, while pens are great tools for describing objects in detail. Taking this idea, a KAIST team introduced a new 3D sketching workflow, combining the strengths of hand and pen input. This technique will ease the way for ideation in three dimensions, leading to efficient product design in terms of time and cost.
For a designer's drawing to become a product in reality, one has to transform a designer's 2D drawing into a 3D shape; however, it is difficult to infer accurate 3D shapes that match the original intention from an inaccurate 2D drawing made by hand. When creating a 3D shape from a planar 2D drawing, unobtainable information is required. On the other hand, loss of depth information occurs when a 3D shape is expressed as a 2D drawing using perspective drawing techniques.
To fill in these “missing links” during the conversion, "3D sketching" techniques have been actively studied. Their main purpose is to help designers naturally provide missing 3D shape information in a 2D drawing. For example, if a designer draws two symmetric curves from a single point of view or draws the same curves from different points of view, the geometric clues that are left in this process are collected and mathematically interpreted to define the proper 3D curve. As a result, designers can use 3D sketching to directly draw a 3D shape as if using pen and paper.
Among 3D sketching tools, sketching with hand motions, in VR environments in particular, has drawn attention because it is easy and quick. But the biggest limitation is that they cannot articulate the design solely using rough hand motions, hence they are difficult to be applied to product designs. Moreover, users may feel tired after raising their hands in the air during the entire drawing process.
Using hand motions but to elaborate designs, Professor Seok-Hyung Bae and his team from the Department of Industrial Design integrated hand motions and pen-based sketching, allocating roles according to their strengths. This new technique is called Agile 3D Sketching with Air Scaffolding. Designers use their hand motions in the air to create rough 3D shapes which will be used as scaffolds, and then they can add details with pen-based 3D sketching on a tablet (Figure 1).
Figure 1. In the agile 3D sketching workflow with air scaffolding, the user (a) makes unconstrained hand movements in the air to quickly generate rough shapes to be used as scaffolds, (b) uses the scaffolds as references and draws finer details with them, (c) produces a high-fidelity 3D concept sketch of a steering wheel in an iterative and progressive manner.
The team came up with an algorithm to identify descriptive hand motions from transitory hand motions and extract only the intended shapes from unconstrained hand motions, based on air scaffolds from the identified motions.
Through user tests, the team identified that this technique is easy to learn and use, and demonstrates good applicability. Most importantly, the users can reduce time, yet enhance the accuracy of defining the proportion and scale of products.
Eventually, this tool will be able to be applied to various fields including the automobile industry, home appliances, animations and the movie making industry, and robotics. It also can be linked to smart production technology, such as 3D printing, to make manufacturing process faster and more flexible.
PhD candidate Yongkwan Kim, who led the research project, said, “I believe the system will enhance product quality and work efficiency because designers can express their 3D ideas quickly yet accurately without using complex 3D CAD modeling software. I will make it into a product that every designer wants to use in various fields.”
“There have been many attempts to encourage creative activities in various fields by using advanced computer technology. Based on in-depth understanding of designers, we will take the lead in innovating the design process by applying cutting-edge technology,” Professor Bae added.
Professor Bae and his team from the Department of Industrial Design has been delving into developing better 3D sketching tools. They started with a 3D curve sketching system for professional designers called ILoveSketch and moved on to SketchingWithHands for designing a handheld product with first-person hand postures captured by a hand-tracking sensor. They then took their project to the next level and introduced Agile 3D Sketching with Air Scaffolding, a new 3D sketching workflow combining hand motion and pen drawing which was chosen as one of the CHI (Conference on Human Factors in Computing Systems) 2018 Best Papers by the Association for Computing Machinery.
- Click the link to watch video clip of SketchingWithHands
2018.07.25 View 8792 -
A New Efficient Oxide Coating Technology to Improve Fuel Cells
A new efficient oxide coating technology that can be applied in less than five minutes could lead to dramatic improvements in the lifetime and performance of fuel cells. The fundamental principle behind this approach is maximizing the oxygen reduction reaction site of a platinum thin-film electrode, preventing the electrodes from aggregating at high temperatures.
Fuel cells have emerged as a clean electricity generation system that does not pollute the air. In particular, solid oxide fuel cells (SOFCs) are beginning to gain a great deal of attention due to their higher power generation efficiency compared to other fuel cells. It is also advantageous to use other power sources than expensive hydrogen fuel.
However, the high costs and insufficient lifetimes caused by high temperatures needed to operate the solid oxide fuel cells have remained significant challenges to commercialization.
Recently, attempts to lower the operating temperature (< 600°C) of these devices by introducing thin-film processes have drew attention of researchers, with the resulting products known as thin-film-based solid oxide fuel cells.
In order to create enhanced device performance at lower temperatures, the research team, led by Professor WooChul Jung in the Department of Materials Science and Engineering, applied and developed oxide coating technology to maximize the oxygen reduction reaction sites of a platinum thin-film electrode and to prevent platinum electrodes from thermal aggregating.
The team succeeded in over-coating a platinum electrode with a new coating material called praseodymium-doped ceria (Pr,Ce)O2-, which has high conductivity for both electrons and oxygen ions and excellent catalytic properties for oxygen reduction reactions. As a result, electrode resistance was reduced by more than 1000 times, creating the potential for these electrodes to be used in high-temperature electrochemical cells.
In addition, they proposed that the high performance of thin-film-based oxide fuel cells’ oxygen electrodes could be realized through the nano-structuring of (Pr,Ce)O2-δ without any platinum.
Professor Jung said, “The electrode coating technology used in this study is of great technical value because of the utilization of affordable and mass-produced electrochemical deposition.” He added, “In the future, this technology will be feasible for replacing platinum electrodes in thin-film-based oxide fuel cells, and we expect that the affordable prices of this fuel cell will eventually boost market competitiveness.”
This research was described in Advanced Energy Materials in July and was featured as the Inside Front Cover and video abstract. It was supported by the Korea Institute of Energy Technology Evaluation and Planning (KETEP) and the Korea Electric Power Corporation (KEPCO) Research Institute.
Figure 1. The change of electrode activity with and without overcoated (Pr,Ce)O2-δ nanostructures.
2018.07.18 View 7900 -
Enhanced PDT to Cure Cancer with Fewer Side Effects
(From left: PhD candidate Ilkoo Noh and Professor Yeu-Chun Kim)
A KAIST research team developed near-infrared fluorophores-based photodynamic therapy (PDT) that reduced the downside of existing PDTs.
PDT is a way to cure wounds with lasers instead of drug treatment. When a laser irradiates a targeted site, a photosensitizer (PS) absorbs light energy and then converts oxygen to singlet oxygen or free radicals, leading to programmed cell death. This treatment has been used widely in clinical fields, especially for skin disease because it allows noninvasive treatment.
However, the existing PDTs have limitations for first-line therapy because PDT agents can cause genetic variations when they have low efficiency, hence reducing treatment effects.
The key to enhancing the efficiency of PDTs is how much PS can be concentrated to a wanted site, which laser wavelength the PS is reacted to, and how fast the PS clears organelle after treatment.
Professor Yeu-Chun Kim and his team from the Department of Chemical and Biomolecular Engineering, in collaboration with Professor Ji-Ho Park from the Department of Bio and Brain Engineering, developed a new PS called mitochondria targeting photodynamic therapeutic agent (MitDt) to maximize PDT effects while reducing unwanted side effects.
Mitochondria has emerged as target sites to maximize the effects of PS since they play essential roles in metabolism and have high transmembrane potential.
According to the team, when mitochondria is photodamaged by reactive oxygen species (ROS) generated after laser irradiation, they immediately lose their mitochondrial membrane potential and initiate apoptosis. Therefore, combining the PDT agent with the mitochondrial targeting agent can result in rapid damage to cancer cells, improving therapeutic efficacy and reducing unwanted side effects.
To successfully apply mitochondria-targeting PS, the team developed near-infrared (NIR) region PDT agents, which can be used to treat deep-tissue level cancer due to the permeability of the NIR laser. Light scattering is also decreased, thus obtaining higher therapeutic efficacy.
However, there is a problem of generating singlet oxygen when irradiating with an NIR laser. To address this issue, the team developed a novel PS that combines a functionalized NIR dye and a mitochondria-targeting agent to gain the benefit of rapid organelle clearance after treatment and also remain in cancer mitochondria for a long time, amplifying the amount of ROS to the target sites irradiated by the laser.
To verify the efficacy, the team injected MitDt into tumor-bearing mice. They were irradiated with an NIR laser at 662 nm to induce cancer treatment and their cancer size was reduced up to three-fold.
PhD candidate Ilkoo Noh, who led this research said, “This enhanced photodynamic cancer treatment has the advantage of treating a wanted site without any side effects because this PS stays longer in a mitochondrial cancer cell. We also confirmed that the PS did not cause cytotoxicity.”
Professor Kim added, “This research outcome will reduce the danger of side effects and can be applied for treating various diseases”.
This research was chosen as the cover page of Advanced Science on March 25.
Figure 1. The cover of Advanced Science
Figure 2. a) Chemical structure of MitDt compounds (above) b) mitochondria localization of designed PS (left) and ROS generation after 662nm laser irradiation (right)
2018.07.16 View 6256 -
Students' Continued Gratitude Extends to Their Spouses
Here is a story of a group of KAIST graduates who still cherish the memory of their professor who passed away in 2003.
They are former students from the Department of Materials Science and Engineering and SDV Lab and their spouses. They created a group, called ‘Chun-sa-heoi’ meaning members who love Dr. Soung-Soon Chun. They reunite every February 26, the date that Dr. Chun passed away.
Chun-sa-heoi is comprised of twelve former students who are now professors, board members of major companies, and an attorney. From his first graduate, Professor Jae Gon Kim at Hanyang University to the most recent graduate, Attorney Jaehwan Kim, Chun-sa-heoi is marking 40 years of their bond.
Dr. Chun was teaching at the University of Utah when he received a call from the Korean government asking him to join KAIST in 1972 as a visiting professor.
He first introduced and established the Department of Materials Engineering, which was considered to be an advanced field at that time. During 30 years of dedication in this field, he fostered 48 Masters and 26 PhD graduates.
Professor Chul Soon Park from the School of Electrical Engineering is one of the former students of Dr. Chun. He explained, “Dr. Chun always cared about his students and guided them in better directions even after they graduated. My gratitude towards him still stays deep in my heart, so I keep maintaining the relationship with him.”
Mrs. Bok Yeon Choi, the spouse of KOREATECH Professor Sang-Ho Kim, first met Dr. Chun and his wife, Myung-Ja Chun in 1987 when she married her husband, who was enrolled in the graduate program at that time. “The Chuns showed affection to not only Dr. Chun’s students but also their families. They took care of us like a family,” she recalled.
Although Dr. Chun passed away in 2003, they continue to pay visits to Mrs. Chun, and they naturally organized this group, expressing gratitude to the Chuns. And their reunions keep on going even after Mrs. Chun moved to Los Angeles where her children are residing. Whenever the former students have a business trip to the U.S, they do not forget to visit Mrs. Chun.
But this year was somewhat more special for Mrs Chun and Chun-sa-heoi. In April, twelve spouses from Chun-sa-heoi invited Mrs. Chun to Hawaii to celebrate her 80th birthday. Mrs. Chun means a lot to the spouses because she has played the role of supporter to them. When they needed advice, she always answered sincerely and encouraged them.
There are numerous relationships among students and professors over the history of KAIST; however, the story of the Chuns and Chun-sa-heoi is very special because their relationship extends to their spouses, beyond the student-professor relationship.
This photo was taken in last April when Chun-sa-heoi celebrated the 80th birthday of Mrs. Chun in Hawaii.
? Who is Dr. Chun?
(Dr. Soung-Soon Chun)
Dr. Chun returned to Korea from the United States in 1972 following a call from the Korean government. At that time, the government policy was to bring back prominent scientists from abroad to develop national science and technology. From the time of KAIST’s foundation, he dedicated himself as a professor. He established the Department of Materials Engineering, where he fostered students and made significant academic contributions in his field.
While holding a position as a professor at the University of Utah, he developed a chemical vapor deposition method with tungsten and applied this method to cutting tools, making a contribution to the economic development of Korea.
When government-funded institutes, including KAIST, faced difficulties due to early retirements and tax credits being cut off, he was appointed as the vice president of KAIST and ardently proposed ways to promote the institute. During his term as vice president and president, he contributed to making KAIST a global research-centered educational institute. Before he passed away at the age of 69 in 2003, he held the position of president of the Daejeon National University of Technology and the Presidential Advisory Council on Science and Technology.
2018.07.13 View 5915 -
Distinguished Professor Lee Receives 2018 George Washington Carver Award
(Distinguished Professor Lee)
Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering will become the 11th recipient of the George Washington Carver Award. The award ceremony will be held during the 2018 Biotechnology Innovation Organization (BIO) World Congress on Industrial Biotechnology from July 16 through 19 at the Pennsylvania Convention Center in Philadelphia.
The annual Carver award recognizes an individual who has made a significant contribution to building the bio-based economy by applying industrial biotechnology to create environmentally sustainable products. It serves as a lasting memorial to the original vision of George Washington Carver who, over a century ago, pioneered bio-based products, materials, and energy derived from renewable agricultural feedstock. Previous recipients include the founder and CEO of POET Jeff Broin, the CEO of DuPont Ellen Kullman, and Professor Gregory Stephanopoulos at MIT.
Professor Lee is a pioneering scholar of systems metabolic engineering, leveraging technology to develop microbial bioprocesses for the sustainable and environment-friendly production of chemicals, fuels, and materials from non-food renewable biomass. He also serves as the dean of the multi-and interdisciplinary research center hub, KAIST Institute.Through his work, Professor Lee has garnered countless achievements, including being one of only 13 people in the world elected as a foreign member of both the National Academy of Sciences USA and the National Academy of Engineering USA.
He has actively promoted the importance of industrial biotechnology through engagement with the public, policymakers, and decision makers around the world. He currently serves as the co-chairman of the Global Future Council on Biotechnology for the World Economic Forum and served as the Chairman of the Emerging Technologies Council and Biotechnology Council for the World Economic Forum.
Upon the award announcement, Dr. Brent Erickson, executive vice president of BIO’s Industrial & Environmental Section lauded Professor Lee’s achievement, saying “Dr. Lee has advanced the bio-based economy by developing innovative products and processes that are sustainable and environmentally friendly. In doing so, he has become a leader in advocating on the importance of industrial biotechnology. His contributions to the advancement of the industry are a continuation of the legacy left behind by George Washington Carver.”
Professor Lee thanked his research team who has worked together for the past few decades, adding, “Industrial biotechnology is becoming increasingly important to help achieve the UN’s Sustainable Development Goals. We should continue to work together to advance the field and establish a solid foundation for the sustainable future.”
The George Washington Carver Award is sponsored by the Iowa Biotechnology Association. Joe Hrdlicka, executive director of the Iowa Biotechnology Association, said, “Dr. Sang Yup Lee’s significant contributions to the advancement of industrial biotechnology make him the perfect recipient for the George Washington Carver Award. Having published more than 575 peer-reviewed papers, contributed to 82 books, and holding 636 patents, the culmination of Dr. Lee’s work has led to the establishment of sustainable systems for bio-based production of chemicals, fuels, and materials, thus reducing environmental impact and improving quality of life for all.”
2018.07.12 View 9692 -
Photonic Capsules for Injectable Laser Resonators
A KAIST research group presented photonic capsules for injectable laser resonators using microfluidic technology. The capsule’s diameter is comparable to a human hair and stable in gas and liquid media, so it is injectable into any target volume.
The research group headed by Professor Shin-Hyun Kim in the Department of Chemical and Biomolecular Engineering applied an interesting optical property from nature. Professor Kim, who has dived deep into photonic materials research inspired from nature such as the Morpho butterfly, used a trait of beetles this time.
Chrysina gloriosa, commonly known as the glorious beetle, shows a green color similar to leaves when illuminated by left-handed, circularly-polarized light while showing no color with right-handed, circularly-polarized light. This unique optical feature helps the beetles communicate with each other and protects them from predators.
The principle behind this interesting optical property of the beetles relies on helical nanostructures with left-handedness that are present on the shell of the beetles. The helical structures reflect a circularly-polarized light with the same handedness of the helix at the wavelength selected by the helical pitch through optical interference.
Such helical nanostructures can be artificially created using liquid crystals (LCs). LCs with a helical arrangement are referred to as cholesteric LCs (CLCs). The CLCs exhibit the polarization-dependent reflection of light in the same manner as the beetles and have been used for various photonic applications.
In particular, CLCs have been cast to a film format that serves as mirrorless laser resonators, unlike conventional lasing systems. However, the film-type CLCs are large in size and show unidirectional emission, which restricts the use of CLC resonators in microenvironments.
To overcome these limitations, Professor Kim’s group has encapsulated the CLCs with dual shells using microfluidic technology. The inner shell is a water layer that promotes the alignment of LC molecules and the outer shell is an elastic polymer layer that secures capsule stability and enables reversible mechanical deformation. The spherical symmetry of the capsules enables omnidirectional laser emissions. Moreover, laser intensity and lasing direction can be further controlled by deforming the capsules, while its wavelength remains tunable. This new type of CLC laser resonator is promising for laser treatments in various biomedical applications.
Professor Kim said, “The helical nanostructure used in the laser resonator resembles that of the shell of chrysina gloriosa. Humans learn from nature and engineer materials to create something unprecedented.”
This research was led by graduate student Sang Seok Lee and an article entitled “Wavelength-tunable and shape-reconfigurable photonic capsule resonators containing cholesteric liquid crystals” was published online on June 22, in Science Advances.
Figure 1. Chrysina gloriosa illuminated by left-handed (left panel) and right-handed (right panel) circularly-polarized lights.
(Image source: https://doi.org/10.1016/j.cub.2010.05.036 , permitted for reuse in news media)
Figure 2. Composition (left panel) and optical microscopy image (right panel) of the capsule-type laser resonator
2018.07.05 View 8572 -
Professor Suh Chosen for IT Young Engineer Award
(The ceremony photo of Professor Changho Suh)
Professor Changho Suh from the School of Electrical Engineering received the IT Young Engineer Award on June 28. This award is hosted by the Institute of Electrical and Electronics Engineers (IEEE) and the Institute of Electrical and Information Engineers (IEIE) and funded by the Haedong Science Foundation.
The IT Young Engineer Award is given to researchers under the age of 40 in Korea. The selection criteria include the researches’ technical practicability, their social and environmental contributions, and their creativity.
Professor Suh has shown outstanding academic performance in the field of telecommunications, distributed storage, and artificial intelligence and he has also contributed to technological commercialization. He published 23 papers in SCI journals and ten papers at top-level international conferences including the Conference on Neural Information Processing Systems and the International Conference on Machine Learning. His papers were cited more than 4,100 times. He has also achieved 30 international patent registrations.
Currently, he is developing an autonomous driving system using an AI-tutor and deep learning technology.
Professor Suh said, “It is my great honor to receive the IT Young Engineer Award. I strive to continue guiding students and carrying out research in order to make a contribution to the fields of IT and AI.”
2018.07.04 View 8058 -
Mechanism Leading to Cortical Malformation from Brain-Only Mutations Identified
Focal malformations of cortical development (FMCDs) are a heterogeneous group of brain cortical abnormalities. These conditions are the most common causes of medically refractory epilepsy in children and are highly associated with intellectual disability, developmental delay, and autism-spectrum disorders. Despite a broad spectrum of cortical abnormalities in FMCDs, the defective migration of neuronal cells is considered a key pathological hallmark.
A research team led by Professor Jeong Ho Lee in the Graduate School of Medical Science and Engineering at KAIST has recently investigated the molecular mechanism of defective neuronal migration in FMCDs. Their research results were published online in Neuron on June 21, 2018.
The research team previously demonstrated that brain-only mutations in the mechanistic target of rapamycin (MTOR) gene causes focal cortical dysplasia, one major form of FMCDs leading to intractable epilepsy in children. However, the molecular mechanisms by which brain-only mutations in MTOR lead to cortical dyslamination and defective neuronal migration in FMCDs remain unclear.
To study the molecular mechanism of brain cortical dyslamination, the research team utilized patients’ brain tissues and modeled the MTOR mutation-carrying cell and animal models recapitulating the pathogenesis and symptoms of FMCD patients. By performing comprehensive molecular genetic experiments, they found that the formation of primary cilia, one of cellular organelles, was disrupted in MTOR mutation-carrying neurons and demonstrated that this ciliary disruption was a cause of cortical dyslamination in FMCDs.
MTOR mutations prevented degradation of the OFD1 protein, one of the negative regulators of ciliary formation. As a result, the OFD1 protein was abnormally accumulated in MTOR mutation-carrying neurons, causing focal cortical dyslamination. By suppressing the expression of the OFD1 protein, the research team was able to rescue the defective formation of primary cilia, leading to the restoration of cortical dyslamination and defective neuronal migration considerably.
Based on these results, the research team is carrying out further research to develop novel therapeutics for patients with FMCDs caused by brain-only mutations.
This work was supported by grants from the Suh Kyungbae Foundation and Citizens United for Research in Epilepsy.
The research paper is titled “Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.” (Digital Object Identifier #: 10.1016/j.neuron.2018.05.039)
Picture 1: The disrupted formation of primary cilia in brain tissues of FMCD mouse models and patients with FMCDs caused by brain somatic mutations in MTOR.
Picture 2: The rescue of defective ciliary formation in FMCD mouse models leading to the restoration of cortical dyslamination and defective neuronal migration.
2018.07.02 View 7992 -
ICT Volunteer Corps Off to Africa
A volunteer corps made up of students will take part in ICT education services in Ethiopia, Tanzania, and Uganda. KAIST students have been volunteering with the ICT education program in Africa since 2015.
The volunteer corps will be made up of 51 students from 13 teams and will be conducting services for a month through the end of July at Addis Ababa Institute of Technology (AAiT) in Ethiopia, Nelson Mandela African Institute of Science and Technology (NM-AIST) and Star High School in Tanzania, and IT Education Center in Uganda.
In Tanzania, KAIST students teamed up with NM-AIST students to carry out appropriate technology programs applied with Arduino kits. They plan to use scientific and engineering approaches to address local residents’ living challenges such as developing agricultural water suppliers using sensors measuring water in the soil and oxygen suppliers in the reservoir.
Meanwhile, in Ethiopia and Uganda, student volunteers will be involved in various ICT educational programs for local students. The volunteering corps will also introduce cultural programs including K-Pop dancing for young students there. They will also engage in sports and art classes for students at orphanages in the region.
President Sung-Chul Shin encouraged volunteers at the kick-off ceremony saying, “KAIST students should keep always humility, warmth, and tolerance in mind. I believe our students will exert leadership out there along with knowledge as well as wisdom.”
2018.07.02 View 5768 -
AST Holdings Makes a Donation to KAIST
(KAIST President Sung-Chul Shin and the CEO of AST Holdings, Haegyoo Seo)
KAIST President Sung-Chul Shin and the CEO of AST Holdings, Haegyoo Seo, agreed to a partnership on June 27 at the main campus of KAIST.
AST Holdings donated one hundred million KRW to the school for fostering experts in the field of augmented reality (AR). The fund will also go to joint research on AR technologies required smart cities.
AST Holdings, established in 1997, specializes in developing VR/AR contents. It has collaborated with Samsung Electronics and KIA Motors to produce various digital contents and develop solutions using VR/AR.
Research and development carried out by the Augmented Reality Research Center (ARRC) of KAIST aims to foster talented manpower and has accumulated crucial components of technology for contributing to research dissemination.
In particular, the ARRC established an industrial, academic, and research partnership that has suggested a new standard for industrial-academic joint research. Under this agreement, an industry assigns its staff to the research center to obtain new technical capabilities while the center strengthens the technological application of a study based on the industrial needs.
Through the partnership funds, the center can provide a stable research environment for young researchers and recruit talented manpower from around the world. The center has the potential to become a new model of industrial-academic research platforms that will take a leading role in the field of VR/AR.
CEO Seo said, “I would like to take the lead in research on VR/AR-based futuristic city platforms through this partnership with KAIST ARRC and the industrial-academic research program. I hope that this partnership between our company and KAIST will create synergy and secure crucial research, manpower, and basic technology according to our company’s needs.
President Shin added, “KAIST will pursue creating an exemplary case of industrial-academic cooperation with outstanding national and international manpower.”
2018.07.02 View 4279 -
KAIST Student Wins HRI Student Design Competition
(From left: Jason Jangho Choi, Hyunjin Ku and Wonkyung Do)
Hyunjin Ku from the Department of Mechanical Engineering won the first prize at the Student Design Competition of Human-Robot-Interaction (HRI) 2018 which was held in Chicago.
Ku teamed up with undergrad students from Seoul National University (Jason Jangho Choi, Soomin Lee, Sunho Jang, and Wonkyung Do) and submitted Shelly, a tortoise-like robot for one-to-many interactions with children.
Figure 1. Shelly, a tortoise-like robot for one-to-many interactions with children
In the Student Design Competition of the HRI, students from around the globe can submit designs for their interactive robotic objects. The competition focused on human-agent interactions and practical applications.
Ku conducted the research while doing an internship at NAVER Labs. Her research on learning robot abuse with Shelly was published in IEEE Spectrum.
[YTN Science]
https://www.youtube.com/watch?v=n5KVwgBk0wk
[HRI 2018 Website]
http://humanrobotinteraction.org/2018/sdc/
[IEEE Spectrum]
https://spectrum.ieee.org/automaton/robotics/robotics-hardware/shelly-robotic-tortoise-helps-kids-learn-that-robot-abuse-is-a-bad-thing
2018.07.02 View 6781