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What Fuels a “Domino Effect” in Cancer Drug Resistance?
KAIST researchers have identified mechanisms that relay prior acquired resistance to the first-line chemotherapy to the second-line targeted therapy, fueling a “domino effect” in cancer drug resistance. Their study featured in the February 7 edition of Science Advances suggests a new strategy for improving the second-line setting of cancer treatment for patients who showed resistance to anti-cancer drugs.
Resistance to cancer drugs is often managed in the clinic by chemotherapy and targeted therapy. Unlike chemotherapy that works by repressing fast-proliferating cells, targeted therapy blocks a single oncogenic pathway to halt tumor growth. In many cases, targeted therapy is engaged as a maintenance therapy or employed in the second-line after front-line chemotherapy.
A team of researchers led by Professor Yoosik Kim from the Department of Chemical and Biomolecular Engineering and the KAIST Institute for Health Science and Technology (KIHST) has discovered an unexpected resistance signature that occurs between chemotherapy and targeted therapy. The team further identified a set of integrated mechanisms that promotes this kind of sequential therapy resistance.
“There have been multiple clinical accounts reflecting that targeted therapies tend to be least successful in patients who have exhausted all standard treatments,” said the first author of the paper Mark Borris D. Aldonza. He continued, “These accounts ignited our hypothesis that failed responses to some chemotherapies might speed up the evolution of resistance to other drugs, particularly those with specific targets.”
Aldonza and his colleagues extracted large amounts of drug-resistance information from the open-source database the Genomics of Drug Sensitivity in Cancer (GDSC), which contains thousands of drug response data entries from various human cancer cell lines. Their big data analysis revealed that cancer cell lines resistant to chemotherapies classified as anti-mitotic drugs (AMDs), toxins that inhibit overacting cell division, are also resistant to a class of targeted therapies called epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).
In all of the cancer types analyzed, more than 84 percent of those resistant to AMDs, representatively ‘paclitaxel’, were also resistant to at least nine EGFR-TKIs. In lung, pancreatic, and breast cancers where paclitaxel is often used as a first-line, standard-of-care regimen, greater than 92 percent showed resistance to EGFR-TKIs. Professor Kim said, “It is surprising to see that such collateral resistance can occur specifically between two chemically different classes of drugs.”
To figure out how failed responses to paclitaxel leads to resistance to EGFR-TKIs, the team validated co-resistance signatures that they found in the database by generating and analyzing a subset of slow-doubling, paclitaxel-resistant cancer models called ‘persisters’.
The results demonstrated that paclitaxel-resistant cancers remodel their stress response by first becoming more stem cell-like, evolving the ability to self-renew to adapt to more stressful conditions like drug exposures. More surprisingly, when the researchers characterized the metabolic state of the cells, EGFR-TKI persisters derived from paclitaxel-resistant cancer cells showed high dependencies to energy-producing processes such as glycolysis and glutaminolysis.
“We found that, without an energy stimulus like glucose, these cells transform to becoming more senescent, a characteristic of cells that have arrested cell division. However, this senescence is controlled by stem cell factors, which the paclitaxel-resistant cancers use to escape from this arrested state given a favorable condition to re-grow,” said Aldonza.
Professor Kim explained, “Before this research, there was no reason to expect that acquiring the cancer stem cell phenotype that dramatically leads to a cascade of changes in cellular states affecting metabolism and cell death is linked with drug-specific sequential resistance between two classes of therapies.”
He added, “The expansion of our work to other working models of drug resistance in a much more clinically-relevant setting, perhaps in clinical trials, will take on increasing importance, as sequential treatment strategies will continue to be adapted to various forms of anti-cancer therapy regimens.”
This study was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF-2016R1C1B2009886), and the KAIST Future Systems Healthcare Project (KAISTHEALTHCARE42) funded by the Korean Ministry of Science and ICT (MSIT). Undergraduate student Aldonza participated in this research project and presented the findings as the lead author as part of the Undergraduate Research Participation (URP) Program at KAIST.
< Figure 1. Schematic overview of the study. >
< Figure 2. Big data analysis revealing co-resistance signatures between classes of anti-cancer drugs. >
Publication:
Aldonza et al. (2020) Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Science Advances, Vol. 6, No. 6, eaav7416. Available online at http://dx.doi.org/10.1126/sciadv.aav7416
Profile: Prof. Yoosik Kim, MA, PhD
ysyoosik@kaist.ac.kr
https://qcbio.kaist.ac.kr/
Assistant Professor
Bio Network Analysis Laboratory
Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
Profile: Mark Borris D. Aldonza
borris@kaist.ac.kr
Undergraduate Student
Department of Biological Sciences
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
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2020.02.10 View 13944 -
New KAA President Chilhee Chung Calls Alumni Engagement a Top Priority
The KAIST Alumni Association (KAA) inaugurated Advisor Chilhee Chung of Samsung Electronics as its new president. President Chung was preceded by Ki-Chul Cha, the CEO of Inbody Co. Ltd. His term as the 25th president starts from February 2020 and ends in January 2022.
President Chung received his master’s degree from KAIST's Department of Physics in 1979 and joined Samsung Electronics the same year. He also holds a doctorate in physics from Michigan State University in the United States.
President Chung devoted himself to helping Samsung Electronics and Korea's system semiconductor and memory device technologies achieve global dominance for more than 40 years. He led future technology development at Samsung Electronics in the fields of quantum dot and neural processing from various leadership positions, including the head of the Semiconductor R&D Center, and the president of Samsung Advanced Institute of Technology (SAIT).
President Chung is currently an advisor to SAIT, a member of the Presidential Advisory Council on Science and Technology (PACST), and the chairman of the 2045 National Future Strategy Committee and the Nano Technology Research Association (NTRA).
President Chung said, “KAIST, throughout its history of half a century, has been working tirelessly to become the world’s best, beyond being the best in Korea. We, the alumni of KAIST, have the commensurate duty as well as the privilege of being proud members of KAIST, as the university's global stature grows.”
“Recently, 46 alumni made 535 million won in donations, and established a scholarship to encourage entrepreneurial spirit in members of the KAIST community. This fund was dedicated to supporting 30 alumni entrepreneurs and students participating in the International Consumer Electronics Show (CES) 2020 that was held in Las Vegas last month. Moreover, another alumnus of ours Byeong-Gyu Chang, the CSO of the KRAFTON Inc., donated 10 billion won to KAIST in hopes of opening up more opportunities that may lead KAIST students to success. Mr. Chang’s donation is by far the largest that has been made by KAIST alumni. I feel grateful to see more alumni getting involved in shaping the future of KAIST these days, and my top priority as the new president of the KAA will be to stimulate the alumni association and engagement in the spirit of ‘Team KAIST’,” he added.
More than 900 alumni, including President Sung-Chul Shin who is also an alumnus of KAIST, gathered in Seoul on January 18 to celebrate the New Year and the newly-elected leadership of the KAA.
(END)
2020.02.03 View 7289 -
Distinguished Alumni Awardees 2019
The KAIST Alumni Association (KAA) announced four recipients of the Distinguished Alumni Awards for the year 2019. The awards ceremony took place during the New Year Alumni Reception on January 18, 2020 in Seoul.
The Distinguished Alumni Awards recognize graduates who have achieved outstanding accomplishments in their professional and personal lives, and who have been an inspiration to fellow alumni and students in Korea and around the globe. The four distinguished alumni of the year 2019 are listed below.
Myung Joon Kim (School of Computing, M.S., Class of ’78), the President of the Electronics and Telecommunications Research Institute (ETRI), is a renowned expert in software engineering who has served as the president of the Administration Division and ICT Creative Research Laboratory of ETRI. His research and leadership have contributed to fortifying the nation’s IT and electronic industry competitiveness.
Dong Ryeol Shin (School of Electrical Engineering, M.S., Class of ’80), the President of Sungkyunkwan University, is a well-versed expert experienced in both academia and industry. He suggested many creative interdisciplinary educational policies and innovative education programs to lead the way in the Fourth Industrial Revolution, and fostered talents who will go on to be the foundation of national development.
Dong-Myun Lee (School of Electrical Engineering, M.S., Class of ’85, Ph.D., Class of ‘87), the CTO and the head of the Institute of Convergence Technology in KT Corporation, is a creative and practical research innovator. He raised the nation’s competitiveness by leading the development of the high-speed communication network industry and the global expansion of next-generation technology business.
Chang Han Kim (School of Computing, B.S., Class of ’92, M.S., Class of ’97, Ph.D., Class of ’98), the CEO of PUBG Corporation, has contributed greatly to the development of the IT contents industry. He developed PlayerUnknown’s Battlegrounds, a game that has become a global sensation.
Since the establishment of the award in 1992, a total of 103 alumni at home and abroad have been honored as recipients, and brought distinction to the university.
These recipients are playing major roles in society, and some of the notable awardees include: KAIST President Sung-Chul Shin (2010), Samsung Electronics Vice Chairman Ki-Nam Kim (2012), Nexon Chairman Jung-Ju Kim (2007), and the former Science and Technology Advisor to the President Kong-Joo Lee (2005).
The President of KAA and the CEO of Inbody Co Ltd., Ki-Chul Cha, said, “The Distinguished Alumni Awards are honor given to the alumni who contributed to the development of the nation and society, and raised the name of their alma mater.” He added, “We can tell the proud position of KAIST in the global arena just by looking at the accomplishments of the previous awardees.”
(END)
2020.01.20 View 9615 -
KAIST and Google Jointly Develop AI Curricula
KAIST selected the two professors who will develop AI curriculum under the auspices of the KAIST-Google Partnership for AI Education and Research. The Graduate School of AI announced the two authors among the 20 applicants who will develop the curriculum next year. They will be provided 7,500 USD per subject.
Professor Changho Suh from the School of Electrical Engineering and Professor Yong-Jin Yoon from the Department of Mechanical Engineering will use Google technology such as TensorFlow, Google Cloud, and Android to create the curriculum.
Professor Suh’s “TensorFlow for Information Theory and Convex Optimization “will be used for curriculum in the graduate courses and Professor Yoon’s “AI Convergence Project Based Learning (PBL)” will be used for online courses. Professor Yoon’s course will explore and define problems by utilizing AI and experiencing the process of developing products that use AI through design thinking, which involves product design, production, and verification. Professor Suh’s course will discus“information theory and convergence,” which uses basic sciences and engineering as well as AI, machine learning, and deep learning.
2019.12.04 View 13316 -
‘Carrier-Resolved Photo-Hall’ to Push Semiconductor Advances
(Professor Shin and Dr. Gunawan (left))
An IBM-KAIST research team described a breakthrough in a 140-year-old mystery in physics. The research reported in Nature last month unlocks the physical characteristics of semiconductors in much greater detail and aids in the development of new and improved semiconductor materials.
Research team under Professor Byungha Shin at the Department of Material Sciences and Engineering and Dr. Oki Gunawan at IBM discovered a new formula and technique that enables the simultaneous extraction of both majority and minority carrier information such as their density and mobility, as well as gain additional insights about carrier lifetimes, diffusion lengths, and the recombination process. This new discovery and technology will help push semiconductor advances in both existing and emerging technologies.
Semiconductors are the basic building blocks of today’s digital electronics age, providing us with a multitude of devices that benefit our modern life. To truly appreciate the physics of semiconductors, it is very important to understand the fundamental properties of the charge carriers inside the materials, whether those particles are positive or negative, their speed under an applied electric field, and how densely they are packed into the material.
Physicist Edwin Hall found a way to determine those properties in 1879, when he discovered that a magnetic field will deflect the movement of electronic charges inside a conductor and that the amount of deflection can be measured as a voltage perpendicular to the flow of the charge. Decades after Hall’s discovery, researchers also recognized that they can measure the Hall effect with light via “photo-Hall experiments”. During such experiments, the light generates multiple carriers or electron–hole pairs in the semiconductors.
Unfortunately, the basic Hall effect only provided insights into the dominant charge carrier (or majority carrier). Researchers were unable to extract the properties of both carriers (the majority and minority carriers) simultaneously. The property information of both carriers is crucial for many applications that involve light such as solar cells and other optoelectronic devices.
In the photo-Hall experiment by the KAIST-IBM team, both carriers contribute to changes in conductivity and the Hall coefficient. The key insight comes from measuring the conductivity and Hall coefficient as a function of light intensity. Hidden in the trajectory of the conductivity, the Hall coefficient curve reveals crucial new information: the difference in the mobility of both carriers. As discussed in the paper, this relationship can be expressed elegantly as: Δµ = d (σ²H)/dσ
The research team solved for both majority and minority carrier mobility and density as a function of light intensity, naming the new technique Carrier-Resolved Photo Hall (CRPH) measurement. With known light illumination intensity, the carrier lifetime can be established in a similar way.
Beyond advances in theoretical understanding, advances in experimental techniques were also critical for enabling this breakthrough. The technique requires a clean Hall signal measurement, which can be challenging for materials where the Hall signal is weak due to low mobility or when extra unwanted signals are present, such as under strong light illumination.
The newly developed photo-Hall technique allows the extraction of an astonishing amount of information from semiconductors. In contrast to only three parameters obtained in the classic Hall measurements, this new technique yields up to seven parameters at every tested level of light intensity. These include the mobility of both the electron and hole; their carrier density under light; the recombination lifetime; and the diffusion lengths for electrons, holes, and ambipolar types. All of these can be repeated N times (i.e. the number of light intensity settings used in the experiment).
Professor Shin said, “This novel technology sheds new light on understanding the physical characteristics of semiconductor materials in great detail.” Dr. Gunawan added, “This will will help accelerate the development of next-generation semiconductor technology such as better solar cells, better optoelectronics devices, and new materials and devices for artificial intelligence technology.”
Profile:
Professor Byungha Shin
Department of Materials Science and Engineering
KAIST
byungha@kaist.ac.kr
http://energymatlab.kaist.ac.kr/
2019.11.18 View 14014 -
Highly Uniform and Low Hysteresis Pressure Sensor to Increase Practical Applicability
< Professor Steve Park (left) and the First Author Mr. Jinwon Oh (right) >
Researchers have designed a flexible pressure sensor that is expected to have a much wider applicability. A KAIST research team fabricated a piezoresistive pressure sensor of high uniformity with low hysteresis by chemically grafting a conductive polymer onto a porous elastomer template.
The team discovered that the uniformity of pore size and shape is directly related to the uniformity of the sensor. The team noted that by increasing pore size and shape variability, the variability of the sensor characteristics also increases.
Researchers led by Professor Steve Park from the Department of Materials Science and Engineering confirmed that compared to other sensors composed of randomly sized and shaped pores, which had a coefficient of variation in relative resistance change of 69.65%, their newly developed sensor exhibited much higher uniformity with a coefficient of variation of 2.43%. This study was reported in Small as the cover article on August 16.
Flexible pressure sensors have been actively researched and widely applied in electronic equipment such as touch screens, robots, wearable healthcare devices, electronic skin, and human-machine interfaces. In particular, piezoresistive pressure sensors based on elastomer‐conductive material composites hold significant potential due to their many advantages including a simple and low-cost fabrication process.
Various research results have been reported for ways to improve the performance of piezoresistive pressure sensors, most of which have been focused on increasing the sensitivity. Despite its significance, maximizing the sensitivity of composite-based piezoresistive pressure sensors is not necessary for many applications. On the other hand, sensor-to-sensor uniformity and hysteresis are two properties that are of critical importance to realize any application.
The importance of sensor-to-sensor uniformity is obvious. If the sensors manufactured under the same conditions have different properties, measurement reliability is compromised, and therefore the sensor cannot be used in a practical setting.
In addition, low hysteresis is also essential for improved measurement reliability. Hysteresis is a phenomenon in which the electrical readings differ depending on how fast or slow the sensor is being pressed, whether pressure is being released or applied, and how long and to what degree the sensor has been pressed. When a sensor has high hysteresis, the electrical readings will differ even under the same pressure, making the measurements unreliable.
Researchers said they observed a negligible hysteresis degree which was only 2%. This was attributed to the strong chemical bonding between the conductive polymer and the elastomer template, which prevents their relative sliding and displacement, and the porosity of the elastomer that enhances elastic behavior.
“This technology brings forth insight into how to address the two critical issues in pressure sensors: uniformity and hysteresis. We expect our technology to play an important role in increasing practical applications and the commercialization of pressure sensors in the near future,” said Professor Park.
This work was conducted as part of the KAIST‐funded Global Singularity Research Program for 2019, and also supported by the KUSTAR‐KAIST Institute.
Figure 1. Image of a porous elastomer template with uniform pore size and shape (left), Graph showing high uniformity in the sensors’ performance (right).
Figure 2. Hysteresis loops of the sensor at different pressure levels (left), and after a different number of cycles (right).
Figure 3. The cover page of Small Journal, Volume 15, Issue 33.
Publication:
Jinwon Oh, Jin‐Oh Kim, Yunjoo Kim, Han Byul Choi, Jun Chang Yang, Serin Lee, Mikhail Pyatykh, Jung Kim, Joo Yong Sim, and Steve Park. 2019. Highly Uniform and Low Hysteresis Piezoresistive Pressure Sensors Based on Chemical Grafting of Polypyrrole on Elastomer Template with Uniform Pore Size. Small. Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany, Volume No. 15, Issue No. 33, Full Paper No. 201901744, 8 pages. https://doi.org/10.1002/smll.201901744
Profile: Prof. Steve Park, MS, PhD
stevepark@kaist.ac.kr
http://steveparklab.kaist.ac.kr/
Assistant Professor
Organic and Nano Electronics Laboratory
Department of Materials Science and Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon 34141, Korea
Profile: Mr. Jinwon Oh, MS
jwoh1701@gmail.com
http://steveparklab.kaist.ac.kr/
Researcher
Organic and Nano Electronics Laboratory
Department of Materials Science and Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr Daejeon 34141, Korea
Profile: Prof. Jung Kim, MS, PhD
jungkim@kaist.ac.kr
http://medev.kaist.ac.kr/
Professor
Biorobotics Laboratory
Department of Mechanical Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr Daejeon 34141, Korea
Profile: Joo Yong Sim, PhD
jsim@etri.re.kr
Researcher
Bio-Medical IT Convergence Research Department
Electronics and Telecommunications Research Institute (ETRI)
https://www.etri.re.krDaejeon 34129, Korea
(END)
2019.08.19 View 27470 -
Research Day Highlights Most Outstanding Research Achievements
Professor Byung Jin Cho from the School of Electrical Engineering was selected as the Grand Research Prize Winner in recognition of his innovative research achievement in the fields of nano electric and flexible energy devices during the 2019 KAIST Research Day ceremony held on April 23 at the Chung Kunmo Conference Hall.
The ten most outstanding research achievements from the past year were also awarded in the three areas of Research, Innovation, Convergence Researches.
Professor Cho is an internationally recognized researcher in the field of future nano and energy device technology. Professor Cho’s team has continued to research on advanced CMOS (complementary metal-oxide semiconductors). CMOS has become his key research topic over the past three decades.
In 2014, he developed a glass fabric-based thermoelectric generator, which is extremely light and flexible and produces electricity from the heat of the human body. It is so flexible that the allowable bending radius of the generator is as low as 20 mm. There are no changes in performance even if the generator bends upward and downward for up to 120 cycles. His wearable thermoelectric generator was selected as one of the top ten most promising digital technologies by the Netexplo Forum in 2015.
He now is working on high-performance and ultra-flexible CMOS IC for biomedical applications, expanding his scope to thermal haptic technology in VR using graphene-CMOS hybrid integrated circuits; to self-powered wireless sensor nodes and self-powered ECG system using wearable thermoelectric generators .
In his special lecture at the ceremony, Professor Cho stressed the importance of collaboration in making scientific research and presented how he moved to future devices after focusing on scaling the devices.
“When I started the research on semiconductors, I focused on how to scale the device down as much as possible. For decades, we have conducted a number of procedures to produce tiny but efficient materials. Now we have shifted to develop flexible thermoelements and wearable devices,” said Professor Cho.
“We all thought the scaling down is the only way to create value-added technological breakthroughs. Now, the devices have been scaled down to 7nm and will go down to 5 nm soon. Over the past few years, I think we have gone through all the possible technological breakthroughs for reducing the size to 5nm. The semiconductor devices are made of more 1 billion transistors and go through 1,000 technological processes. So, there won’t be any possible way for a single genius to make a huge breakthrough. Without collaboration with others, it is nearly impossible to make any new technological breakthroughs.”
Professor Cho has published more than 240 papers in renowned academic journals and presented more than 300 papers at academic conferences. He has also registered approximately 50 patents in the field of semiconductor device technology.
The top ten research highlights of 2018 as follows:
- Rydberg-Atom Quantum Simulator Development by Professor Jaewook Ahn and Heung-Sun Sim from the Department of Physics
- From C-H to C-C Bonds at Room Temperature by Professor Mu-Hyun Baik from the Department of Chemistry
- The Role of Rodlike Counterions on the Interactions of DNAs by Professor Yong Woon Kim of the Graduate School of Nanoscience and Technology
- The Medal Preoptic Area Induces Hunting-Like Behaviors to Target Objects and Prey by Professor Daesoo Kim from the Department of Biological Sciences
- Identification of the Origin of Brain Tumors and New Therapeutic Strategy by Professor Jeong Ho Lee from the Graduate School of Medical Science and Engineering
- The Linear Frequency Conversion of Light at a Spatiotemporal Boundary by Professor Bumki Min from the Department of Mechanical Engineering
- An Industrial Grade Flexible Transparent Force Touch Sensor by Professor Jun-Bo Yoon from the School of Electrical Engineering
- The Detection and Clustering of Mixed-Type Defect Patterns in Wafer Bin Maps by Professor Heeyoung Kim from the Department of Industrial and Systems Engineering
- The Development of a Reconfigurable Spin-Based Logic Device by Professor Byong-Guk Park from the Department of Materials Science and Engineering
- The Development of a Miniaturized X-Ray Tube Based on Carbon Nanotube and Electronic Brachytherapy Device by Professor Sung Oh Cho from the Department of Nuclear and Quantum Engineering
Professor YongKeun Park from the Department of Physics and Professor In-Chel Park from the School of Electrical Engineering received the Research Award. For the Innovation Award, Professor Munchurl Kim from the School of Electrical Engineering was the recipient and the Convergence Research Awards was conferred to Professor Sung-Yool Choi from the School of Electrical Engineering, Professor Sung Gap Im from the Department of Chemical and Biomolecular Engineering, and Professor SangHee Park from the Department of Materials Science and Engineering during the ceremony.
For more on KAIST’s Top Research Achievements and Highlight of 2018, please refer to the attached below. click.
2019.04.25 View 15647 -
KAIST 2019 Commencement at a Glance
(KAIST 2019 Commencement Ceremony)
This year, KAIST awarded a total of 2,705 degrees: 654 PhD degrees, 1,255 master’s degrees, and 796 bachelor’s degrees. Including this year’s numbers, KAIST has conferred a total of 63,830 degrees since its foundation in 1971.
Parents, family, and friends came to campus to congratulate the graduates with big smiles and hugs. Faculty and staff members also attended the ceremony to celebrate their graduation. This year, distinguished guests including National Assembly Member Kyung-Jin Kim and Vice Minister for Science, Technology and Innovation Dae-sik came to celebrate the day with the KAIST community.
During the commencement, KAIST also announced the recipients of its undergraduate academic awards. The Minister of Science and ICT Award was won by Do-Yoon Kim from the Department of Aerospace Engineering, the KAIST Board of Trustee Chairperson Award went to Se-rin Lee from the Department of Materials Science and Engineering, the KAIST Presidential Award was won by Hee-Ju Kim from the Department of Physics, the KAIST Alumni Association President Award went to Hyeon-Seong Park from the School of Electrical Engineering, and finally the KAIST Development Foundation Chairperson Award was won by Gyeong-Hoon Lee from the Department of Mathematical Sciences.
This year’s valedictorian Eun-Seok Jeong from the School of Computing said, “I believe that we are able to stand here today because we challenged ourselves to confront our shortcomings and our uncertainty. If we continue to develop, we will become a better person than we were yesterday.”
(KAIST President Sung-Chul Shin and Woo-Seok Jeong, '19 PhD in Aerospace Engineering)
As a KAIST alumnus and fellow scientist, President Sung-Chul Shin offered his congratulations and emphasized that graduates should continue to pursue the C³ spirit. “In this age of great transformation, embrace challenges and exercise creativity as you have learnt through your education and research at KAIST. And keep in mind the importance of caring for others. Please remember that challenge and creativity will have more meaning if rendered with a caring spirit,” he said.
2019.02.15 View 10153 -
Professor Jeong-Ho Lee Named the KAISTian of 2018
(Professor Jeong-Ho Lee (right) poses with President Sung-Chul Shin)
Professor Jeong-Ho Lee from the Graduate School of Medical Science and Engineering was selected as the KAISTian of the Year of 2018. The award was established in 2001 and recognizes the most outstanding scholars who have made significant research and scholastic achievements during the year. Professor Lee was awarded during the New Year ceremony held in the auditorium on January 2.
Professor Lee has investigated mutations arising in the brain for decades and has published in renowned journals such as Nature, Nature Medicine, and Cell. Last August, Professor Lee reported breakthrough research on glioblastoma in Nature, giving insight into understanding how the mutation causing glioblastoma starts and suggested novel ways to treat glioblastoma, which was thought to be incurable. (Click for more)
Professor Lee’s Translational Neurogenetics Laboratory lab is investigating innovative diagnostics and therapeutics for untreatable brain disorders including intractable epilepsy and glioblastoma. To commercialize his technology, he established the tech-startup SoVarGen and now works as its CTO.
Professor Lee credited all his lab colleagues and staff. “I know all of this research would not have possible without their sweat and effort. I am happy to receive this honorable award on behalf of them.”
Remembering the beginning of his career at KAIST in 2012, Professor Lee said “KAIST seemed to be a very high and formidable barrier for me, after completing my medical education in Korea. I thank my department professors and colleagues who led me to focus on the research path that I really wanted. They provided everything for my research environment to help make good results.”
“I will continue to strive for promoting the well-being of humanity by addressing various incurable diseases as well as developing novel therapeutics. That will be the way to promote the stature of KAIST at home and abroad,” he added.
2019.01.02 View 5789 -
Team KAT Wins the Autonomous Car Challenge
(Team KAT receiving the Presidential Award)
A KAIST team won the 2018 International Autonomous Car Challenge for University Students held in Daegu on November 2.
Professor Seung-Hyun Kong from the ChoChunShik Graduate School of Green Transportation and his team participated in this contest with the team named KAT (KAIST Autonomous Technologies). The team received the Presidential Award with a fifty million won cash prize and an opportunity for a field trip abroad.
The competition was conducted on actual roads with Connected Autonomous Vehicles (CAV), which incorporate autonomous driving technologies and vehicle-to-everything (V2X) communication system.
In this contest, the autonomous vehicles were given a mission to pick up passengers or parcels. Through the V2X communication, the contest gave current location of the passengers or parcels, their destination, and service profitability according to distance and level of service difficulty.
The participating vehicles had to be equipped very accurate and robust navigation system since they had to drive on narrow roads as well as go through tunnels where GPS was not available. Moreover, they had to use camera-based recognition technology that was invulnerable to backlight as the contest was in the late afternoon.
The contest scored the mission in the following way: the vehicles get points if they pick up passengers and safely drop them off at their destination; on the other hand, points are deducted when they violate lanes or traffic lights. It will be a major black mark if a participant sitting in the driver’s seat needs to get involved in driving due to a technical issue.
Youngbo Shim of KAT said, “We believe that we got major points for technical superiority in autonomous driving and our algorithm for passenger selection.”
This contest, hosted by Ministry of Trade, Industry and Energy, was the first international competition for autonomous driving on actual roads. A total of nine teams participated in the final contest, four domestic teams and five teams allied with overseas universities such as Tsinghua University, Waseda University, and Nanyang Technological University.
Professor Kong said, “There is still a long way to go for fully autonomous vehicles that drive flexibly under congested traffic conditions. However, we will continue to our research in order to achieve high-quality autonomous driving technology.”
(Team KAT getting ready for the challenge)
2018.11.06 View 11309 -
ICT Volunteer Corps Off to Africa
A volunteer corps made up of students will take part in ICT education services in Ethiopia, Tanzania, and Uganda. KAIST students have been volunteering with the ICT education program in Africa since 2015.
The volunteer corps will be made up of 51 students from 13 teams and will be conducting services for a month through the end of July at Addis Ababa Institute of Technology (AAiT) in Ethiopia, Nelson Mandela African Institute of Science and Technology (NM-AIST) and Star High School in Tanzania, and IT Education Center in Uganda.
In Tanzania, KAIST students teamed up with NM-AIST students to carry out appropriate technology programs applied with Arduino kits. They plan to use scientific and engineering approaches to address local residents’ living challenges such as developing agricultural water suppliers using sensors measuring water in the soil and oxygen suppliers in the reservoir.
Meanwhile, in Ethiopia and Uganda, student volunteers will be involved in various ICT educational programs for local students. The volunteering corps will also introduce cultural programs including K-Pop dancing for young students there. They will also engage in sports and art classes for students at orphanages in the region.
President Sung-Chul Shin encouraged volunteers at the kick-off ceremony saying, “KAIST students should keep always humility, warmth, and tolerance in mind. I believe our students will exert leadership out there along with knowledge as well as wisdom.”
2018.07.02 View 6775 -
KAIST Team Reaching Out with Appropriate Technology
(The gold prize winning team of KATT)
The KAIST Appropriate Technology Team (KATT) consisting of international students at KAIST won the gold and silver prizes at ‘The 10th Creative Design Competition for the Other 90 Percent.’
More than 218 students from 50 teams nationwide participated in the competition hosted by the Ministry of Science and ICT last month.
The competition was created to discover appropriate technology and sustainable design items to enhance the quality of life for those with no or few accessible technologies.
A team led by Juan Luis Gonzalez Bello, graduate student from the School of Electrical Engineering received the gold prize for presenting a prosthetic arm. Their artificial arm was highly recognized for its affordability and good manageability. The team said that it cost less than 10 US dollars to construct from materials available in underprivileged regions and was easy to assemble.
Sophomore Hutomo Calvin from the Department of Materials Science & Engineering also worked on the prosthetic arm project with freshmen Bella Godiva, Stephanie Tan, and Koptieuov Yearbola.
Alexandra Tran, senior from the School of Electrical Engineering led the silver prize winning team. Her team developed a portable weather monitor, ‘Breathe Easy’. She worked with Alisher Tortay, senior from the School of Computing, Ashar Alam, senior from the Department of Mechanical Engineering, Bereket Eshete, junior from the School of Computing, and Marthens Hakzimana, sophomore from the Department of Mechanical Engineering.
This weather monitor is a low-cost but efficient air quality monitor. The team said it just cost less than seven US dollars to construct the monitor.KAIST students have now won the gold prize for two consecutive years.
2018.06.19 View 10805