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Affordable Genetic Diagnostic Technique for Target DNA Analysis Developed
Professor Hyun-Gyu Park of the Department of Chemical and Biomolecular Engineering at KAIST has developed a technique to analyze various target DNAs using an aptamer, a DNA fragment that can recognize and bind to a specific protein or enzyme. This technique will allow the development of affordable genetic diagnoses for new bacteria or virus, such as Middle Ease Respiratory Syndrome (MERS). The research findings were published in the June issue of Chemical Communications, issued by the Royal Society of Chemistry in the United Kingdom. The paper was selected as a lead article of the journal.
The existing genetic diagnosis technique, based on molecular beacon probes, requires a new beacon probe whenever a target DNA mutates. As a result, it was costly to analyze various target DNA fragments. To address this problem, Professor Park’s team designed an aptamer that binds and deactivates DNA polymerase. The technique was used in reverse, so that the aptemer did not bind to the polymerase, maintaining its activated state, only if the target DNA was present. These probes are called TagMan probes.
The controlled activation and deactivation of DNA polymerase enables nucleic acid to elongate or dwindle, making it possible to measure fluorescence signals coming from TaqMan probes. This same probe can be used to detect various target DNAs, leading to the development of a new and sensitive genetic diagnostic technique.
Unlike the existing molecular beacon probe technique which requires a new probe for every target DNA, this new technique uses the same fluorescent TaqMan probe, which is cheaper and easier to detect a number of different target nucleic acid fragments. The application of this technique will make the process of identifying and detecting foreign DNAs from pathogens such as virus and bacteria more affordable and simple.
Professor Park said, “This technique will enable us to develop simpler diagnostic kits for new pathogens, such as MERS, allowing a faster response to various diseases. Our technology can also be applied widely in the field of genetic diagnostics.”
Picture: A schematic image of target nucleic acid extracted through the activation and deactivation of DNA polymerase
2015.07.31 View 9594 -
KAIST Agrees to Cooperate with Three Hospitals in the Delivery of Emergency Medical Services
KAIST signed an agreement with three major hospitals in Korea, the National Police Hospital, Seoul National University Hospital in Bundang, and the Armed Forces Capital Hospital, to respond to national emergency situations such as the outbreak of epidemic diseases.
The signing ceremony for the agreement took place on July 27, 2015, at the JW Marriott Hotel in Seoul.
Under the agreement, the four institutions will cooperate in conducting research in basic medical science to develop treatments and vaccines, building a system to deliver emergency medical services including the establishment of preventive measures against epidemics, and providing emergency medical assistance to under-developed countries.
This agreement was initiated by the Institute of Disaster Studies at KAIST.
President Steve Kang of KAIST said, “Korean society has recently experienced the importance of building a network of medical intuitions and research universities to handle national emergency situations when Middle East Respiratory Syndrome hits the nation hard. We need to prepare for epidemics and biological disasters, and this agreement is the first step towards serving such need.”
From the left to the right in the picture are: President Hong-Soon Lee of the National Police Hospital, President Steve Kang of KAIST, President Myung-Chul Lee of the Armed Forces Capital Hospital, and President Ho-Sung Han of Seoul National University Hospital in Bundang.
2015.07.31 View 4566 -
KAIST Operates a Summer School with Imperial College London
KAIST and Imperial College London jointly hosted a summer school on the KAIST campus on July 14-17, 2015. Twenty-five students from both universities, 11 from KAIST and 14 from Imperial College, participated in the summer program.
KAIST and Imperial College agreed to hold academic and research exchange programs in 2013; this year’s summer school represented the first effort.
Participants were divided into a few cohorts of four or five students. They conducted a series of activities to implement joint research projects involving team building, networking, joint study, discussions, and presentations.
Among the projects the summer school ran, Professor Hoi-Jun Yoo of the Electrical Engineering Department at KAIST was invited to teach students about the mobile healthcare system, Dr. M, that he had developed.
Sung-Hyon Myaeng, Associate Vice President of the International Affairs Office, KAIST, said, “This summer school is yet another example of KAIST’s ongoing efforts to make the campus more global and to interact actively with members of the international community.”
2015.07.29 View 7241 -
International Undergraduate Conference ICISTS-KAIST 2015 and ICISTS-KAIST Public Colloquium Held on August 3, 2015 at KAIST
The ICISTS-KAIST 2015, an international conference organized by a student organization called the International Conference for the Integration of Science, Technology, and Society at KAIST, was held from August 3rd to 7th at the KAIST campus and ICC Hotel in Daejeon. This year’s conference theme was “Shaping the Future.” Over 300 undergraduate students from more than 20 countries joined the event. The conference offered opportunities to explore emerging issues in science and technology, particularly in the fields of robotics, medicine, and science communication.
Vitalic Buterin, a rising scientist who received the 2014 World Technology Award for his development of the Ethereum Project, and Alan Irwin, a renowned scholar in science communication at the Copenhagen Business School in Denmark, were invited as keynote speakers. The list of other speakers included Stefan Lorenz Sorgner, the Director and Co-founder of the Beyond Humanism Network; Wendell Wallach, a scholar at Yale University's Interdisciplinary Center for Bioethics; and Hideto Nakajima, a professor at the Department of History, Philosophy and Social Studies of Science and Technology at Tokyo Institute of Technology.
As part of the ICISTS-KAIST 2015, ICISTS also hosted a public colloquium on August 5, 2015 at the Science Hall in Daejeon National Science Museum. Ko San, the Director of TIDE Institute; Hyo-Joon Woo, the Chief Executive Officer of Fransen; and Dong-Il Jung, the Chief Executive Officer of iDrone participated as the speakers.
2015.07.29 View 6695 -
Professor Suk-Joong Kang Receives the Richard Brook and Helmholtz Awards
Professor Suk-Joong Kang of KAIST’s Department of Materials Sciences and Engineering received the Richard Brook Award from the European Ceramic Society at its 14th conference held on June 21, 2015, in Toledo, Spain. The award is presented to the most distinguished academic or engineer in ceramics from a non-European country. Professor Kang gave the commemorative lecture after the award ceremony.
Professor Kang is an expert in the field of sintering and microstructural evolution in ceramics and metals. He suggested a new model for grain growth and identified the principles of microstructural evolution.
He also received the 2015 Helmholtz Fellow Award in June. The Helmholtz Association, the largest scientific organization in Germany, confers the award on outstanding senior scientists based outside Germany who have made great academic and research achievements in their fields.
Professor Kang said of the Brook Award, “It is such an honor to receive an award from an eminent global institution. I take this opportunity to thank my students and colleagues for their support, and I will work harder for my research.”
2015.07.20 View 5751 -
KAIST Undergraduates Organize the Largest Interdisciplinary Conference in Asia
The largest interdisciplinary conference in Asia hosted by KAIST undergraduates for students around the world will be held in KAIST. The organizing committee of International Conference for the Integration of Science, Technology and Society (ICISTS) will hold the ICISTS-KAIST 2015 in KAIST and Hotel ICC from August 3-7, 2015, with around 300 Korean and international participants.
ICISTS-KAIST was established in 2005 to provide an annual platform for students to discuss the integration and the convergence of science, technology and society, regardless of their academic background.
This year’s theme is "Shaping the Future" and the topics for the conference are robotics, medicine, and science communication.
The keynote speakers are Vitalic Buterin, the winner of the World Technology Award in 2014 for the co-creation and invention of Ethereum and Alan Irwin, a well-known scholar of science, technology and society as well as the Dean of Research at the Copenhagen Business School in Denmark.
Other notable speakers include Adam Marcus, a professor of Hematology and Medical Oncology, Emory University School of Medicine; Stefan Lorenz Sorgner, the Director and co-founder of Beyond Humanism Network; Hideto Nakajima, a professor in the Department of History, Philosophy and Social Studies of Science and Technology at Tokyo Institute of Technology; Wendell Wallach, a lecturer at the Yale University Interdisciplinary Center for Bioethics; Jinil Lee, a professor in the Division of Biological Science and Technology at Yonsei University; and Sangwook Kim, an editor of APCTP web journal Crossroads and a professor in the Department of Physics Education, Pusan National University.
Last year, more than 300 students from 50 different countries attended the ICISTS-KAIST 2014 as delegates to exchange their thoughts and ideas on science, technology, and society.
To register for the event, please visit www.icists.org.
2015.07.14 View 7190 -
Dong-Young Lee, a Doctoral Candidate, Receives the Best Paper Award
Dong-Young Lee, a Ph.D. candidate in the Mechanical Engineering Department, KAIST, received the Best Paper Award at the 18th International Conference on Composite Structures (ICCS). The event was held in Lisbon, Portugal, on June 15-18, 2015. Mr. Lee’s adviser is Professor Dai-Gil Lee of the same department.
The ICCS is held every other year, and is one of the largest and long-established conferences on composite materials and structures in the world. At this year’s conference, a total of 680 papers were presented, among which, two papers were chosen for the Best Paper Award, including Mr. Lee’s.
The paper, entitled “Gasket-integrated Carbon and Silicon Elastomer Composite Bipolar Plate for High-temperature PEMFC,” will be published in the September issue of Composite Structures which is one of the top journals in mechanical engineering as judged by the Google Scholar Metrics rankings.
Mr. Lee dropped the conventional method of PEMFC (Proton Exchange Membrane Fuel Cells) assembly and instead developed a gasket-integrated carbon and silicone elastomer composite bipolar plate. This technology significantly increased the energy efficiency of fuel cells and their productivity.
Mr. Lee said, “I would like to thank the many people who supported me, especially my Ph.D. adviser, Professor Dai-Gil Lee. Without their encouragement, I would have not won this award. I hope my research will contribute to solving energy problems in the future.”
In addition, Professor Joon-Woo Im from Chonbuk National University, Senior Researcher Il-Bum Choi from the Agency for Defense Development, and a fellow doctoral candidate Soo-Hyun Nam from KAIST participated in this research project.
2015.07.09 View 8116 -
The Minister of Education of Kazakhstan Visits KAIST
The Minister of Education of the Republic of Kazakhstan, Aslan Sarinzhipov, and his delegation visited KAIST on June 30, 2015.
Dr. Young-Suk Ji, the Chairman of Elsevier, an academic publishing company that publishes medical and scientific literature, arranged the visit.
The Kazakh delegation showed great interest in KAIST’s educational system and research programs during their meeting with President Steve Kang of KAIST. In particular, the delegation was most impressed by the startups and entrepreneurship programs established at the KAIST Pangyo Innovation Center.
President Kang said, “I hope the Minister’s visit will help inspire more Kazakh students to come to Korea and study at KAIST.”
Kazakhstan, located in the northern part of Central Asia, gained its independence in 1991 after the collapse of the Soviet Union. Currently, there are 22 Kazakh students studying at KAIST.
2015.07.03 View 4503 -
Professor Jae Kyu Lee Appointed the President of Association for Information Systems
Chair Professor Jae Kyu Lee of KAIST’s College of Business was appointed the President of Association for Information Systems (AIS) on July 1, 2015. Professor Lee will serve a one-year term, which will end in June 2016. With four thousand members researching information systems from 90 different nations, AIS is the largest academic society in the fields of information system and business process engineering.
Professor Lee has proposed his idea of “the Bright Internet” as the official vision of AIS. Employing this vision, AIS will create technology and systems, as well as sponsor international cooperation to solve fundamental issues of the Internet including concerns over hacking and cyber-related crimes.
The extent of damage from cyber-related crimes grows each year. Every day, 56 billion junk emails are sent to computers which are hacked and become “zombie” computers. The social cost of such crimes is estimated to be 400 billion US dollars annually.
Based on "the Bright Internet," AIS will build a preventative Internet security system by adopting ground rules that make attackers responsible for the damages from such crimes. The system will also modify technology and other systems to minimize privacy infringement while maintaining security. Finally, the Bright Internet proposes to adopt an international standard for this security system through collaboration with the International Telecommunications Union (ITU).
Professor Lee said, “The vision of the Bright Internet started from an awareness that we needed to resolve issues such as Internet addiction, indiscriminate media exposure, and verbal violence. This vision developed by the experts from all around the world will not only bring a revolution of a reliable Internet platform to a global scale but also reshape the Korean Internet platform.”
2015.07.02 View 6807 -
KAIST Professor Sung-Ju Lee Appointed a Technical Program Chair of INFOCOM
Professor Sung-Ju Lee of the Department of Computer Science at KAIST has been appointed to serve as a technical program chair of IEEE INFOCOME. The computer communication conference, started in 1982, is influential in the research fields of the Internet, wireless, and data centers.
Professor Lee is the first Korean to serve as a program chair. He has been acknowledged for his work in network communications. In the 34th conference, which will be held next year, he will take part in selecting 650 experts in the field to become members and supervise the evaluation of around 1,600 papers.
Professor Lee is the leading researcher in the field of wireless mobile network systems. He is a fellow of the Institute of Electrical and Electronics Engineers (IEEE) and served as the general chair of the 20th Association for Computing Machinery (ACM) SIGMOBILE Annual International Conference on Mobile Computing & Networking (MobiCom 2014). He is on the editorial boards of IEEE Transactions on Mobile Computing (TMC) and IEEE Internet of Things Journals.
Professor Lee said, “I hope to continue the traditions of the conference, as well as integrating research from various areas of network communication. I will strive to create a program with high technology transfer probability.”
The 34th IEEE INFOCOM will take place in San Francisco in April 2016.
2015.07.02 View 7356 -
Professor Naehyuck Jang was Appointed Technical Program Chair of the Design Automation Conference
Professor Naehyuck Jang of the Electrical Engineering Department at KAIST was appointed as the technical program chair of the Design Automation Conference (DAC). He is the first Asian to serve the conference as the chair. At next year’s conference, he will select 150 program committee members and supervise the selection process of 1,000 papers.
Founded in 1964, DAC encompasses research related to automation of semiconductor processes, which usually involve billions of transistors. More than seven thousand people and 150 companies from all around the world participate, of which only the top 20% of the submitted papers are selected. It is the most prestigious conference in the field of semiconductor automation.
The Design Automation Conference also introduces optimization and automation of design processes of systems, hardware security, automobiles, and the Internet of things. Professor Jang specializes in low power system designs. As an ACM Distinguished Scientist, Professor Jang was elected as the chairman after contributing to this year’s program committee by reforming the process of selection of papers.
Professor Jang said, “This year’s conference represents a departure, where we move from the field of traditional semiconductors to the optimization of embedded system, the Internet of things, and security. He added that “we want to create a paper selection process that can propose the future of design automation.”
The 53rd annual DAC will take place at the Austin Convention Center in Texas in June 2016.
2015.07.02 View 5920 -
3D Plasmon Antenna Capable of Focusing Light into Few Nanometers
Professors Myung-Ki Kim and Yong-Hee Lee, both of the Physics Department at KAIST, and their research teams have developed a three dimensional (3D) gap-plasmon antenna which can focus light into a space a few nanometers wide. Their research findings were published in the June 10th issue of Nano Letters.
Focusing light into a point-like space is an active research field with many applications. However, concentrating light into a smaller space than its wavelength is often hindered by diffraction. To tackle this problem, many researchers have utilized the plasmonic phenomenon of a metal where light can be confined to a greater extent by overcoming the diffraction limit.
Many researchers have focused on developing a two dimensional (2D) plasmon antenna and were able to focus a light under 5 nanometers wide. However, this 2D antenna revealed a challenge: the light disperses to the opposite end regardless of how small its beam was focused. To solve this difficulty, a 3D structure had to be employed to maximize the light's intensity.
Adopting the proximal focused-ion-beam milling technology, the KAIST research team developed a 3D four nanometer wide gap-plasmon antenna. By squeezing the photons into a 3D nano space of 4 x 10 x 10 nm3 size, the researchers were able to increase the intensity of light by 400,000 times stronger than that of the incident light. Capitalizing on the enhanced intensity of light within the antenna, they intensified the second-harmonic signal and verified that the light was focused in the nano gap by scanning cathodoluminescent images.
The researchers anticipate that this technology will improve the speed of data transfer and processing up to the level of a terahertz (one trillion times per second) and to enlarge the storage volume per unit area on hard disks by 100 times. In addition, high definition images of submolecule size can be taken with actual light, instead of with an electron microscope, while improving the semiconductor process to a smaller size of few nanometers.
Professor Kim said, “A simple yet ingenious idea has shifted the research paradigm from 2D gap-plasmon antennas to 3D antennas. This technology will see numerous applications including in the field of information technology, data storage, imaging medical science, and semiconductor processes.”
The research was sponsored by the National Research Foundation of Korea.
Figure 1: 3D Gap-Plasmon Antenna Structure and Simulation Results
Figure 2 – Constructed 3D Gap-Plasmon Antenna Structure
Figure 3 – Amplified Second Harmonic Signal Generation and Light Focused in the Nano Gap
2015.06.24 View 9694