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KAIST and Hancom Sign for Development of Mobile Healthcare
KAIST signed a memorandum of understanding with Hancom, Inc., an office suite developer in Korea, to foster mobile healthcare software programs. President Steve Kang and Chairman Sang-Chul Kim of Hancom held a signing ceremony on March 13, 2015 at the KAIST campus.
Based on the agreement, KAIST and Hancom will exchange research personnel to build Dr. M, a smart healthcare platform developed by the university, collaborate in research and development, and cooperate in the transfer of research developments from the university to the software industry including Hancom.
KAIST and Hancom also signed a memorandum of understanding on the development of software in April 2014. The Hancom-KAIST Research Center opened on campus last October.
2015.03.20 View 9457 -
KAIST Exhibits Socially Benign Technologies
Exhibited 29 products that address the need to solve social issues such as a Braille printer
Students from the KAIST Idea Factory, a startup program for undergraduates operated by the Research Institute for Social Technology and Innovation (RISTI), hosted an exhibition presenting their research prototypes. The Idea Factory provides students with opportunities to try out new ideas and develop innovative technologies.
The exhibition was held at the Creative Learning building on campus on March 20, 2015. Students displayed 29 inventions, showcasing technologies to address important social issues. The exhibit included products and technologies developed by the students or already commercialized by small businesses such as a Braille printer, a hydrogen peroxide-oxygen respirator for vessel accidents, and an educational 3D printer. The small business exhibits included a removable additional power unit for wheelchairs, agricultural product anti-theft system, and security lighting.
KAIST also hosted a social technology innovation symposium in KAIST Institute Building on the same day. The theme of the symposium was the “Integration of Technological Innovation and Social Innovation – Social Technology Innovation.”
The key note speaker, Director Heung-Kyu Lee of RISTI, KAIST, presented a lecture on the topic, “The Meaning of Social Technology Innovation: System Change.” His talk was followed by Hyuk-Jin Choi of the Korea Social Enterprise Promotion Agency on “Social Economic Organizations of Korea and Social Technology,” and Jae-Sun Kim of The Grassroots on “Search for Social Innovation and Social Economy.”
The supervisor of the event, Director Lee said, “This exhibit focuses on technologies that could help the underprivileged. We will continue to support students’ ideas and small businesses’ endeavors to develop these technologies.”
KAIST established the Idea Factory in 2014 to assist KAIST students to commercialize creative and innovative ideas. The Idea Factory made a key contribution in commercializing the educational 3D printers last year.
Picture: A Braille Printer
2015.03.20 View 7477 -
Emeritus Professors' Social Service for Embracing Multicultural Families
Korea has become a melting pot over recent years, with many families embracing diverse nationalities, cultures, and ethnicities. A group of KAIST emeritus professors volunteered to help these multicultural families, which are often formed through international marriages, better cope with life in Korea by creating a continuing education program called “Multicultural Mother School.”
The school admitted a total of ten non-Korean mothers for its first class and held an entrance ceremony for the students on March 14, 2015, at the IFC Hope Church in Daejeon. Classes began since March 16, 2015, offering the first lecture to students remotely via the Internet.
Professor Emeritus Byung-Kyu Choi, who organized the volunteering program and is the director of the Multicultural Mother School, said, “About 5% of newborns in Korea currently come from multicultural families. It is important that we should support them to assimilate well into the Korean society. Since 60% of multicultural children have yet to enter the public school system, particularly at the elementary schools level, offering their mothers opportunities to learn more about Korea will serve a greater good.”
2015.03.14 View 6375 -
KAIST Introduces New UI for K-Glass 2
A newly developed user interface, the “i-Mouse,” in the K-Glass 2 tracks the user’s gaze and connects the device to the Internet through blinking eyes such as winks. This low-power interface provides smart glasses with an excellent user experience, with a long-lasting battery and augmented reality.
Smart glasses are wearable computers that will likely lead to the growth of the Internet of Things. Currently available smart glasses, however, reveal a set of problems for commercialization, such as short battery life and low energy efficiency. In addition, glasses that use voice commands have raised the issue of privacy concerns.
A research team led by Professor Hoi-Jun Yoo of the Electrical Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST) has recently developed an upgraded model of the K-Glass (http://www.eurekalert.org/pub_releases/2014-02/tkai-kdl021714.php) called “K-Glass 2.”
K-Glass 2 detects users’ eye movements to point the cursor to recognize computer icons or objects in the Internet, and uses winks for commands. The researchers call this interface the “i-Mouse,” which removes the need to use hands or voice to control a mouse or touchpad. Like its predecessor, K-Glass 2 also employs augmented reality, displaying in real time the relevant, complementary information in the form of text, 3D graphics, images, and audio over the target objects selected by users.
The research results were presented, and K-Glass 2’s successful operation was demonstrated on-site to the 2015 Institute of Electrical and Electronics Engineers (IEEE) International Solid-State Circuits Conference (ISSCC) held on February 23-25, 2015 in San Francisco. The title of the paper was “A 2.71nJ/Pixel 3D-Stacked Gaze-Activated Object Recognition System for Low-power Mobile HMD Applications” (http://ieeexplore.ieee.org/Xplore/home.jsp).
The i-Mouse is a new user interface for smart glasses in which the gaze-image sensor (GIS) and object recognition processor (ORP) are stacked vertically to form a small chip. When three infrared LEDs (light-emitting diodes) built into the K-Glass 2 are projected into the user’s eyes, GIS recognizes their focal point and estimates the possible locations of the gaze as the user glances over the display screen. Then the electro-oculography sensor embedded on the nose pads reads the user’s eyelid movements, for example, winks, to click the selection. It is worth noting that the ORP is wired to perform only within the selected region of interest (ROI) by users. This results in a significant saving of battery life. Compared to the previous ORP chips, this chip uses 3.4 times less power, consuming on average 75 milliwatts (mW), thereby helping K-Glass 2 to run for almost 24 hours on a single charge.
Professor Yoo said, “The smart glass industry will surely grow as we see the Internet of Things becomes commonplace in the future. In order to expedite the commercial use of smart glasses, improving the user interface (UI) and the user experience (UX) are just as important as the development of compact-size, low-power wearable platforms with high energy efficiency. We have demonstrated such advancement through our K-Glass 2. Using the i-Mouse, K-Glass 2 can provide complicated augmented reality with low power through eye clicking.”
Professor Yoo and his doctoral student, Injoon Hong, conducted this research under the sponsorship of the Brain-mimicking Artificial Intelligence Many-core Processor project by the Ministry of Science, ICT and Future Planning in the Republic of Korea.
Youtube Link:
https://www.youtube.com/watchv=JaYtYK9E7p0&list=PLXmuftxI6pTW2jdIf69teY7QDXdI3Ougr
Picture 1: K-Glass 2
K-Glass 2 can detect eye movements and click computer icons via users’ winking.
Picture 2: Object Recognition Processor Chip
This picture shows a gaze-activated object-recognition system.
Picture 3: Augmented Reality Integrated into K-Glass 2
Users receive additional visual information overlaid on the objects they select.
2015.03.13 View 16575 -
Professor Sangyong Jon Appointed Fellow of AIMBE
Professor Sangyong Jon of the Department of Biological Sciences at KAIST has been appointed a member of the American Institute for Medical and Biological Engineering (AIMBE) fellowship.
Established in 1991, AIMBE is a non-profit organization based in Washington, D.C., representing 50,000 individuals and the top 2% of medical and biological engineers. AIMBE provides policy advice and advocacy for medical and biological engineering for the benefit of humanity. It has had about 1,500 fellows over the past 25 years. Among the members, only 110 are non-American nationalities.
Following the appointment of Dr. Hae-Bang Lee, the former senior researcher at the Korean Research Institute of Chemical Technology, and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST, Professor Jon is the third Korean to become an AIMBE fellow. He had an induction ceremony for the appointment of his fellowship at the AIMBE’s Annual Event held on March 15-17, 2015 in Washington, D.C.
An authority on nanomedicine, Professor Jon has developed many original technologies including multi-functional Theranostics nano particles for the diagnosis and treatment of diseases. He received the Most Cited Paper Award from Theranostics, an academic journal specialized in nanomedicine, last February.
Additionally, Professor Jon is a leading researcher in the field of translational medicine, using a multi-disciplinary, highly collaborative, “Bench to Bedside” approach for disease treatment and prevention. He created a biotechnology venture company and transferred research developments to the industry in Korea.
2015.03.12 View 12788 -
System Approach Using Metabolite Structural Similarity Toward TOM Suggested
A Korean research team at KAIST suggests that a system approach using metabolite structural similarity helps to elucidate the mechanisms of action of traditional oriental medicine.
Traditional oriental medicine (TOM) has been practiced in Asian countries for centuries, and is gaining increasing popularity around the world. Despite its efficacy in various symptoms, TOM has been practiced without precise knowledge of its mechanisms of action. Use of TOM largely comes from empirical knowledge practiced over a long period of time. The fact that some of the compounds found in TOM have led to successful modern drugs such as artemisinin for malaria and taxol (Paclitaxel) for cancer has spurred modernization of TOM.
A research team led by Sang-Yup Lee at KAIST has focused on structural similarities between compounds in TOM and human metabolites to help explain TOM’s mechanisms of action. This systems approach using structural similarities assumes that compounds which are structurally similar to metabolites could affect relevant metabolic pathways and reactions by biosynthesizing structurally similar metabolites.
Structural similarity analysis has helped to identify mechanisms of action of TOM. This is described in a recent study entitled “A systems approach to traditional oriental medicine,” published online in Nature Biotechnology on March 6, 2015. In this study, the research team conducted structural comparisons of all the structurally known compounds in TOM and human metabolites on a large-scale. As a control, structures of all available approved drugs were also compared against human metabolites. This structural analysis provides two important results. First, the identification of metabolites structurally similar to TOM compounds helped to narrow down the candidate target pathways and reactions for the effects from TOM compounds. Second, it suggested that a greater fraction of all the structurally known TOM compounds appeared to be more similar to human metabolites than the approved drugs. This second finding indicates that TOM has a great potential to interact with diverse metabolic pathways with strong efficacy. This finding, in fact, shows that TOM compounds might be advantageous for the multitargeting required to cure complex diseases. “Once we have narrowed down candidate target pathways and reactions using this structural similarity approach, additional in silico tools will be necessary to characterize the mechanisms of action of many TOM compounds at a molecular level,” said Hyun Uk Kim, a research professor at KAIST.
TOM’s multicomponent, multitarget approach wherein multiple components show synergistic effects to treat symptoms is highly distinctive. The researchers investigated previously observed effects recorded since 2000 of a set of TOM compounds with known mechanisms of action. TOM compounds’ synergistic combinations largely consist of a major compound providing the intended efficacy to the target site and supporting compounds which maximize the efficacy of the major compound. In fact, such combination designs appear to mirror the Kun-Shin-Choa-Sa design principle of TOM.
That principle, Kun-Shin-Choa-Sa (君臣佐使 or Jun-Chen-Zuo-Shi in Chinese) literally means “king-minister-assistant-ambassador.” In ancient East Asian medicine, treating human diseases and taking good care of the human body are analogous to the politics of governing a nation. Just as good governance requires that a king be supported by ministers, assistants and/or ambassadors, treating diseases or good care of the body required the combined use of herbal medicines designed based on the concept of Kun-Shin-Choa-Sa. Here, the Kun (king or the major component) indicates the major medicine (or herb) conveying the major drug efficacy, and is supported by three different types of medicines: the Shin (minister or the complementary component) for enhancing and/or complementing the efficacy of the Kun, Choa (assistant or the neutralizing component) for reducing any side effects caused by the Kun and reducing the minor symptoms accompanying major symptom, and Sa (ambassador or the delivery/retaining component) which facilitated the delivery of the Kun to the target site, and retaining the Kun for prolonged availability in the cells.
The synergistic combinations of TOM compounds reported in the literature showed four different types of synergisms: complementary action (similar to Kun-Shin), neutralizing action (similar to Kun-Choa), facilitating action or pharmacokinetic potentiation (both similar to Kun-Choa or Kun-Sa). Additional structural analyses for these compounds with synergism show that they appeared to affect metabolism of amino acids, co-factors and vitamins as major targets.
Professor Sang Yup Lee remarks, “This study lays a foundation for the integration of traditional oriental medicine with modern drug discovery and development. The systems approach taken in this analysis will be used to elucidate mechanisms of action of unknown TOM compounds which will then be subjected to rigorous validation through clinical and in silico experiments.”
Sources: Kim, H.U. et al. “A systems approach to traditional oriental medicine.” Nature Biotechnology. 33: 264-268 (2015).
This work was supported by the Bio-Synergy Research Project (2012M3A9C4048759) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. This work was also supported by the Novo Nordisk Foundation.
The picture below presents the structural similarity analysis of comparing compounds in traditional oriental medicine and those in all available approved drugs against the structures of human metabolites.
2015.03.09 View 10666 -
Interactions Features KAIST's Human-Computer Interaction Lab
Interactions, a bi-monthly magazine published by the Association for Computing Machinery (ACM), the largest educational and scientific computing society in the world, featured an article introducing Human-Computer Interaction (HCI) Lab at KAIST in the March/April 2015 issue (http://interactions.acm.org/archive/toc/march-april-2015).
Established in 2002, the HCI Lab (http://hcil.kaist.ac.kr/) is run by Professor Geehyuk Lee of the Computer Science Department at KAIST. The lab conducts various research projects to improve the design and operation of physical user interfaces and develops new interaction techniques for new types of computers. For the article, see the link below:
ACM Interactions, March and April 2015
Day in the Lab: Human-Computer Interaction Lab @ KAIST
http://interactions.acm.org/archive/view/march-april-2015/human-computer-interaction-lab-kaist
2015.03.02 View 10462 -
Professor Sang Yup Lee Appointed Founding Board Member of Cell Systems
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed a member of the founding editorial board of the newly established journal Cell Systems.
Cell Systems will be a sister journal of Cell, one of the three most prestigious scientific journals along with Nature and Science, that publishes a wide range of papers on biological engineering. The first issue of Cell Systems will be published this July.
Cell Systems plans to publish innovative discoveries, reviews of various research instruments, and research findings on integrated and quantified systems in the field of biology.
Professor Lee is a pioneer in metabolic engineering of microorganism with a focus on biopolymers and metabolites production. He is the editor-in-chief of Biotechnology Journal and serves on the editorial board of numerous international journals. He is also a member of the Global Agenda Council of the World Economic Forum and the Presidential Advisory Committee on Science and Technology in Korea.
Professor Lee said, “Cell Systems will present research findings that discuss whole biological systems methodically.” He continued, “I hope many research findings of Korean scholars will be published in Cell Systems, which will become a representative journal of systems biology and systems biological engineering.”
2015.02.13 View 9720 -
KAIST's Thermoelectric Generator on Glass Fabric Receives the Grand Prize at the Netexplo Forum 2015
The forum announced top ten IT innovations expected to change the world and selected the grand prize on February 4, 2014.
Established in 2007 by Martine Bidegain and Thierry Happe in partnership with the French Senate and the French Ministry for the Digital Economy, the Netexplo Observatory is an independent global organization that studies the impact of digital technology and innovation on society and business.
Every year, the Netexplo Observatory hosts an international conference, the Netexplo Forum, in Paris, France, which surveys digital innovation worldwide. The 8th forum was held in partnership with the United Nations Educational, Scientific and Cultural Organization (UNESCO) on February 4-5, 2015, at the UNESCO House in Paris.
Prior to the conference, the Netexplo Forum 2015 named the top ten most promising digital technologies that will greatly impact the world.
Among them was Professor Byung Jin Cho’s research on a wearable thermoelectric generator (http://www.eurekalert.org/pub_releases/2014-04/tkai-tgo041014.php). The generator was selected as the most innovative technology this year.
Professor Cho of KAIST’s Electrical Engineering Department developed a glass fabric-based thermoelectric generator that is extremely light and flexible and that produces electricity from the heat of the human body. This technology can be applied widely to wearable computers and mobile devices.
The full list of innovations follows below:
Wearable Thermo-Element, South Korea: The human body becomes a source of energy for mobile devices.
W.Afate 3D-printer, Togo: An environmentally friendly fablab that makes a low-cost 3D-printer from recycling electronic components.
Slack, USA: By combining email, Skype, and file-sharing and social networks, internal communication becomes much easier and simpler.
PhotoMath, Croatia: A free app that enables smartphone users to solve mathematical problems simply by scanning the mathematical texts.
Kappo, Chile: Connected cyclists produce and transmit useful data for urban planning to make the city more bike-friendly.
Branching Minds, USA: An improved learning process for students in difficulty through a personalized approach.
Baidu Kuai Sou, China: Smart chopsticks that can check food hazards.
SCio, Israel: A pocket molecular sensor with various applications and data
Rainforest Connection, USA: Fighting deforestation with recycled smartphones
Sense Ebola Followup, Nigeria: A mobile tool to help contain Ebola
For more details on the wearable thermos-element which received the 2015 Netexplo Award, please go to https://www.netexplo.org/en/intelligence/innovation/wearable-thermo-element.
Pictures 1 and 2: A high-performance wearable thermoelectric generator that is extremely flexible and light.
Picture 3: Senator Catherine Morin-Desailly (left) of the French Parliament presents the 2015 Netexplo Award to Professor Byung Jin Cho (right) on February 4, 2015 at the UNESCO House in Paris.
Credit of Loran Dhérines
Picture 4: Professor Byung Jin Cho (left) poses with Dr. Joël de Rosnay (right).
Credit of Loran Dhérines
2015.02.06 View 14519 -
"Software Welcomes Girls" Camp at KAIST
KAIST’s Department of Computer Science organized a software (SW) training camp from January 25-29, 2015 in the Creative Learning Building on campus to promote talented women for the field of information technology (IT).
Hosted by the National Information Society Agency in Korea and the Korea Foundation for the Advancement of Science and Creativity, the training camp was comprised of a junior program to educate primary and secondary school students along with teachers and parents, while university students, software developers, and female professionals who had interrupted their careers participated in a senior camp.
In the junior camp, participants learned how to employ Scratch and App Inventor as well as microprocessors by using Arduino and Raspberry Pi. During the camp, students including those from multicultural families attended lectures from professors and software designers and received a career consulting session from them. The conference organizers will provide long-term mentoring for the primary and secondary school students by graduate student participants and other volunteer experts.
The senior camp consisted of a program entitled “More Women, Better SW!” and a special lecture on “Women in SOS (Software Optimization Services)” took place at Google Korea. University students, teachers, and SW developers had an opportunity to design applications intended to improve daily living. At the “Women in SOS” program, Professor Alice Oh of KAIST and other industry experts gave talks about successful women IT personnel and digital literacy.
One of the organizers, Professor Yoon-Joon Lee from the Computer Science Department said, “Software-centered societies in the future will demand delicate intuition and cooperative leadership, which are characteristics of women.” He added that “I hope more women become interested in this field through this event.”
2015.02.02 View 7921 -
Danish Minister for Higher Education and Science Visits KAIST
Sofie Carsten Nielsen, the Minister for Higher Education and Science of Denmark, accompanied by her delegation, visited KAIST on January 21, 2015 to study outstanding cases of creative economy and to discuss methods of cooperation.
Her delegation included other distinguished members including Thomas Lehmann, the Danish ambassador to Korea, Peter Olesen, Chairman of Innovation Foundation Denmark Governing Board, and Martin Bendsøe, Senior Vice President and Dean of Technical University of Denmark.
After attending the "Electronic Communication Double Degree Agreement" signing ceremony between KAIST’s Department of Electrical Engineering and the Technical University of Denmark, Minister Nielsen visited KAIST’s Institute of Entrepreneurship to observe bilateral industry-university collaborations between KAIST and Denmark and discussed future development plans.
Also, the Grundfos Student Innovation Camp, sponsored by Grundfos, the world's largest pump manufacturer based in Denmark, took place at KAIST from October 26-31, 2014 where Grundfos professionals as well as students from Seoul National University, KAIST, and Technical University of Denmark (DTU) exchanged ideas and opinions on energy efficiency.
KAIST is currently conducting 19 collaborative projects including seven joint researches and seven joint degrees with DTU.
Minister Sofie Carsten Nielsen stands fifth from the left in the front row in the first picture below.
2015.01.27 View 9616 -
Light Driven Drug-Enzyme Reaction Catalytic Platform Developed
Low Cost Dye Used, Hope for Future Development of High Value Medicinal Products to Treat Cardiovascular Disease and Gastric Ulcers
A KAIST research team from the Departments of Materials Science and Engineering and of Chemical and Biomolecular Engineering, led respectively by Professors Chan Beum Park and Ki Jun Jeong, has developed a new reaction platform to induce drug-enzyme reaction using light.
The research results were published in the journal Angewandte Chemie, International Edition, as the back cover on 12 January 2015.
Applications of this technology may enable production of high value products such as medicine for cardiovascular disease and gastric ulcers, for example Omeprazole, using an inexpensive dye.
Cytochrome P450 is an enzyme involved in oxidative response which has an important role in drug and hormone metabolism in organisms. It is known to be responsible for metabolism of 75% of drugs in humans and is considered a fundamental factor in new drug development.
To activate cytochrome P450, the enzyme must receive an electron by reducing the enzyme. In addition, NADPH (a coenzyme) needs to be present. However, since NADPH is expensive, the use of cytochrome P450 was limited to the laboratory and has not yet been commercialized.
The research team used photosensitizer eosin Y instead of NADPH to develop “Whole Cell Photo-Biocatalysis” in bacteria E. coli. By exposing inexpensive eosin Y to light, cytochrome P450 reaction was catalyzed to produce the expensive metabolic material.
Professor Park said, “This research enabled industrial application of cytochrome P450 enzyme, which was previous limited.” He continued, “This technology will help greatly in producing high value medical products using cytochrome P450 enzyme.”
The research was funded by the National Research Foundation of Korea and KAIST's High Risk High Return Project (HRHRP).
Figure 1: Mimetic Diagram of Electron Transfer from Light to Cytochrome P450 Enzyme via Eosin Y, EY
Figure 2: The back cover of Angewandte Chemie published on 12 January 2015, showing the research results
2015.01.26 View 10673