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Binding Regulatory Mechanism of Protein Biomolecules Revealed
Professor Hak-Sung Kim
A research team led by Professor Hak-Sung Kim of Biological Sciences, KAIST, and Dr. Mun-Hyeong Seo, KAIST, has revealed a regulatory mechanism that controls the binding affinity of protein’s biomolecules, which is crucial for the protein to recognize molecules and carry out functions within the body.
The research results were published in the April 24th online edition of Nature Communications.
The protein, represented by enzyme, antibody, or hormones, specifically recognizes a variety of biomolecules in all organisms and implements signaling or immune response to precisely adjust and maintain important biological processes. The protein binding affinity of biomolecules plays a crucial role in determining the duration of the bond between two molecules, and hence to determine and control the in-vivo function of proteins.
The researchers have noted that, during the process of proteins’ recognizing biomolecules, the protein binding affinity of biomolecules is closely linked not only to the size of non-covalent interaction between two molecules, but also to the unique kinetic properties of proteins.
To identify the basic mechanism that determines the protein binding affinity of biomolecules, Professor Kim and his research team have made mutation in the allosteric site of protein to create a variety of mutant proteins with the same chemical binding surface, but with the binding affinity vastly differing from 10 to 100 times. The allosteric site of the protein refers to a region which does not directly bind with biomolecules, but crucially influences the biomolecule recognition site.
Using real-time analysis at the single-molecule level of unique kinetic properties of the produced mutant proteins, the researchers were able to identify that the protein binding affinity of biomolecules is directly associated with the protein’s specific kinetic characteristics, its structure opening rate.
Also, by proving that unique characteristics of the protein can be changed at the allosteric site, instead of protein’s direct binding site with biomolecules, the researchers have demonstrated a new methodology of regulating the in-vivo function of proteins.
The researchers expect that these results will contribute greatly to a deeper understanding of protein’s nature that governs various life phenomena and help evaluate the proof of interpreting protein binding affinity of biomolecules from the perspective of protein kinetics.
Professor Kim said, “Until now, the protein binding affinity of biomolecules was determined by a direct interaction between two molecules. Our research has identified an important fact that the structure opening rate of proteins also plays a crucial role in determining their binding affinity.”
[Picture]
A correlation graph of opening rate (kopening) and binding affinity (kd) between protein’s stable, open state and its unstable, partially closed state.
2014.05.02 View 10144 -
Leon Chua, the founder of the circuit theory called "memristor," gave a talk at KAIST
Dr. Leon Ong Chua is a circuit theorist and professor in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley. He visited KAIST on April 16, 2014 and gave a talk entitled “Memristor: New Device with Intelligence.”
Dr. Chua contributed to the development of nonlinear circuit theory and cellular neural networks (CNN). He was also the first to conceive of memristor which combines the characteristics of memory and resistor. Memristor is a type of resistor, remembering the direction and charge of electrical current that has previously flowed through the resistor. In other words, memristor can retain memory without power. Today, memristor is regarded as the fourth fundamental circuit element, together with capacitors, inductors, and resistors.
In 2008, researchers at Hewlett-Packard (HP) Labs developed the first working model of memristor, which was reported in Nature (May 1st , 2008).
In addition, Dr. Chua is an IEEE fellow and has received numerous awards including the IEEE Kirchhoff Award, the IEEE Neural Network Pioneer Award, the IEEE Third Millennium Medal, and the Top 15 Most Cited Author in Engineering Award.
2014.04.21 View 10397 -
Strawberries Delivered by A Miniature Drone at KAIST Spring Festival
The "HAPPY KAIST 2014 Spring Festival" held at KAIST from 4th April
The Cherry Blossoms Festival under the theme of "Cherry Blossoms: Light and Fantasy" held on 4th April
The Strawberry Party with strawberries exclusively delivered by a miniature drone on 11th April
KAIST is holding a spring festival from April 4th through 11th.
As a part of the "HAPPY KAIST 2014" event, cherry blossoms festival and strawberry party will be held at KAIST campus starting on April 4th.
This event has been organized with the purpose of creating a new culture and tradition for members of KAIST to unite. Faculty members, staff, and students have all contributed to making the festival a success.
The cherry blossoms festival, held under the theme of "Cherry Blossoms: Light and Fantasy," takes place at the road in front of the KAIST north dormitory, which provides a spectacular view of cherry blossom trees. It begins on the night of April 4th and continues until the 8th of April.
Around the cherry blossom tree road displays an art exhibition by the Design Rangers, a student club of graduate and doctorate students from the Department of Industrial Design at KAIST. The exhibition includes the "Fantasy Cherry Blossoms" and "Let’s Walk Together."
Following on the 11th will be the "Strawberry Party" to take place throughout the campus. The strawberry party began in 1995 in order to help the local strawberry farmers. Now, it has become KAIST’s own unique tradition attended by faculty, student clubs, and laboratory members.
This year, the fruit party becomes a unique event in that there will be a demonstration of strawberry delivery by an unmanned vehicle or an unmanned aerial vehicle (a miniature drone).
When a customer orders strawberries via a smart phone application, the user's current location is sent to the central system of an unmanned vehicle. Either the unmanned vehicle (UV) transports strawberries or for places
inaccessible
by the UV such as on a lawn, the drone delivers the fruit to the customer
.
This demonstration has been organized by Professor Hyunchul Shim from the Department of Aerospace Engineering at KAIST. Professor Shim said, “If the unmanned logistics system, such as the one being demonstrated at the Strawberry Party, is commercialized, both cost and time
in the logistics industry
can be significantly reduced.”
The HAPPY KAIST 2014,
organized
by the College of Engineering, is an annual event, consisting of a total of five programs, with the purpose to make the campus happier and
healthier.
2014.04.07 View 9881 -
An Electron Cloud Distribution Observed by the Scanning Seebeck Microscope
All matters are made of small particles, namely atoms. An atom is composed of a heavy nucleus and cloud-like, extremely light electrons.
Korean researchers developed an electron microscopy technique that enables the accurate observation of an electron cloud distribution at room-temperature. The achievement is comparable to the invention of the quantum tunneling microscopy technique developed 33 years ago.
Professor Yong-Hyun Kim of the Graduate School of Nanoscience and Technology at KAIST and Dr. Ho-Gi Yeo of the Korea Research Institute of Standards and Science (KRISS) developed the Scanning Seebeck Microscope (SSM). The SSM renders clear images of atoms, as well as an electron cloud distribution. This was achieved by creating a voltage difference via a temperature gradient.
The development was introduced in the online edition of Physical Review Letters (April 2014), a prestigious journal published by the American Institute of Physics.
The SSM is expected to be economically competitive as it gives high resolution images at an atomic scale even for graphene and semiconductors, both at room temperature. In addition, if the SSM is applied to thermoelectric material research, it will contribute to the development of high-efficiency thermoelectric materials.
Through numerous hypotheses and experiments, scientists now believe that there exists an electron cloud surrounding a nucleus. IBM's Scanning Tunneling Microscope (STM) was the first to observe the electron cloud and has remained as the only technique to this day. The developers of IBM microscope, Dr. Gerd Binnig and Dr. Heinrich Rohrer, were awarded the 1986 Nobel Prize in Physics.
There still remains a downside to the STM technique, however: it required high precision and extreme low temperature and vibration. The application of voltage also affects the electron cloud, resulting in a distorted image.
The KAIST research team adopted a different approach by using the Seebeck effect which refers to the voltage generation due to a temperature gradient between two materials.
The team placed an observation sample (graphene) at room temperature (37~57℃) and detected its voltage generation. This technique made it possible to observe an electron cloud at room temperature.
Furthermore, the research team investigated the theoretical quantum mechanics behind the electron cloud using the observation gained through the Seebeck effect and also obtained by simulation capability to analyze the experimental results.
The research was a joint research project between KAIST Professor Yong-Hyun Kim and KRISS researcher Dr. Ho-Gi Yeo. Eui-Seop Lee, a Ph.D. candidate of KAIST, and KRISS researcher Dr. Sang-Hui Cho also participated. The Ministry of Science, ICT, and Future Planning, the Global Frontier Initiative, and the Disruptive Convergent Technology Development Initiative funded the project in Korea.
Picture 1: Schematic Diagram of the Scanning Seebeck Microscope (SSM)
Picture 2: Electron cloud distribution observed by SSM at room temperature
Picture 3: Professor Yong-Hyun Kim
2014.04.04 View 14829 -
Partnership Agreement between KAIST and SK Telecom for Cyber Security
KAIST
and SK Telecom, one of the largest wireless telecommunications operators in
Korea, signed a memorandum of understanding on the industry and university cooperation
to establish a research center for cyber security on March 18, 2014.
The
center will conduct research projects to improve privacy protection, develop core
technologies needed for cyber security, train engineers and researchers, and
host seminars and conferences.
The
two organizations will implement the first joint research project on the
development of software-defined network-based solutions and universal subscriber
identity module-based personal identification solutions.
2014.03.26 View 7441 -
Extreme Tech: Nanowire "impossible to replicate" fingerprints could eliminate fraud, counterfeit goods
Research done by Professor Hyun-Joon Song of Chemistry at KAIST on
anti-counterfeit, nanoscale fingerprints generated by randomly distributed
nanowires was introduced by Extreme Tech, an online global science and technology
news.
For the articles, please go to:
Extreme Tech, March 25, 2014Nanowire ‘impossible to replicate’ fingerprints could eliminate fraud, counterfeit goods
http://www.extremetech.com/extreme/179131-nanowire-impossible-to-replicate-fingerprints-could-eliminate-fraud-counterfeit-goods
2014.03.26 View 8787 -
Science Daily: Nanostructured Capsules Could Bring About Paints and Electronic Displays That Never Fade
A collaborative research by Professor Shin-Hyun Kim of Chemical and Bimolecular Engineering, KAIST, and his student, Tae-Min Choi, on nano-structural colors with Harvard University was published by Science Daily on March 14, 2014.
For the article, please go to:
Science Daily,
March 14, 2014
Featured Research
"Brighter inks, without pigment: Nanostructured capsules could bring about paints and electronic displays that never fade"
http://www.sciencedaily.com/releases/2014/03/140314164214.htm
2014.03.17 View 9580 -
Tae-Wan Kim, a doctoral candidate, receives the best paper award from ECTC
The 2014 Electronic Components and Technology Conference (ECTC) will take place on May 27-30 in Florida, USA. Tae-Wan Kim, a Ph.D. candidate at the Department of Materials Science Engineering (MSE), KAIST, will receive the Intel Best Student Paper Award at the conference.ECTC is the premier international conference that brings together the best researchers and engineers in packaging, components and microelectronic systems science, technology and education in an environment of cooperation and technical exchange. The conference is sponsored by the Components, Packaging and Manufacturing Technology (CPMT) Society of IEEE (Institute of Electrical and Electronics Engineering).The paper describes research on novel nanofiber anisotropic conductive films for ultra fine pitch electronic package application, which was written under the guidance of Professor Kyung-Wook Paik of the MSE Department. In the past ten years, two of his students have received the best paper award from ECTC.
2014.03.14 View 11780 -
Visit by Sir Paul Maxime Nurse, President of the Royal Society
Sir Paul Maxime
Nurse, who is an English geneticist and cell biologist, visited KAIST and gave
a lecture entitled The Great Ideas of
Biology on March 11, 2014.
Sir Paul was awarded the 2001 Nobel Prize in
Physiology or Medicine with Leland H. Hartwell and R. Timothy Hunt for their discoveries
of protein molecules that control the division of cells in the cell cycle.
He was Professor of Microbiology at the University
of Oxford, CEO of the Imperial Cancer Research Fund and Cancer Research UK, and
President of Rockefeller University in New York. Sir Paul is currently the President of
the Royal Society as well as Director and Chief Executive of the Francis Crick
Institute.
Founded in London in 1660, the Royal Society is composed of the world’s most distinguished scientists drawn from all areas of
science, engineering, and medicine.
Below is a summary of his lecture, The Great Ideas of Biology:
Four major ideas of biology
are the theory of genes, evolution by natural selection, the proposal that the
cell is the fundamental unit of all life, and the chemical composition of a cell.
When considering the
question “what is life?” these ideas come together. The special way cells reproduce
provides the conditions by which natural selection takes place, allowing living
organisms to evolve. The organization of chemistry within the cell provides
explanations for life’s phenomena.
In addition, an emerging idea
is the nature of biological self-organization with which living cells and organisms
process information and acquire specific forms. These great ideas have
influenced one another and changed the way we perceive biology and science
today.
2014.03.11 View 10758 -
Book Announcement: Sound Visualization and Manipulation
The movie
Gravity
won seven Oscar awards this year, one of which was for its outstanding 3D sound mixing, immersing viewers in the full experience of the troubled space expedition.
3D audio effects are generated by manipulating the sound produced by speakers, speaker-arrays, or headphones to place a virtual sound source at a desired location in 3D space such as behind, above, or below the listener's head.
Two professors from the Department of Mechanical Engineering at KAIST have recently published a book that explains two important technologies related to 3D sound effects: sound visualization and manipulation.
Professor Yang-Hann Kim, an eminent scholar in sound engineering, and Professor Jung-Woo Choi collaborated to write Sound Visualization and Manipulation (Wily 2013), which uniquely addresses the two most important problems in the field in a unified way.
The book introduces general concepts and theories and describes a number of techniques in sound visualization and manipulation, offering an interrelated approach to two very different topics: sound field visualization techniques based on microphone arrays and controlled sound field generation techniques using loudspeaker arrays.
The authors also display a solid understanding of the associated physical and mathematical concepts applied to solve the visualization and manipulation problems and provide extensive examples demonstrating the benefits and drawbacks of various applications, including beamforming and acoustic holography technology.
The book will be an excellent reference for graduate students, researchers, and professionals in acoustic engineering, as well as in audio and noise control system development.
For detailed descriptions of the book:
http://as.wiley.com/WileyCDA/WileyTitle/productCd-1118368479.html
2014.03.10 View 13620 -
The 4th Meeting of Korea and Denmark Alliance for Green Growth
President Steve Kang attended the “Fourth Meeting of Korea and Denmark Alliance for Green Growth” which took place on March 6, 2014 at the Shilla Hotel in Seoul. President Kang was a keynote speaker at the meeting and gave a lecture on sustainable energy.
KAIST and the Technical University of Denmark (DTU) signed a memorandum of understanding (MOU) on the “Cooperation for Innovation and Entrepreneurship” at the meeting.
In the MOU, KAIST and DTU agreed to post the information on their websites regarding the patents acquired through the implementation of joint research programs. In addition, KAIST students will attend conferences and idea competitions organized by DTU, e.g., the Green Challenges. DTU students will participate in KAIST’s conferences and competitions including “Startup KAIST Global Idea Competition.”
2014.03.07 View 8649 -
KAIST Holds Open Lecture For Daejeon Residents
Free of cost for any Korean citizen, the registration for the new course opens on the official website from 5th March KAIST’s Department of Humanities and Social Science is currently operating free humanities and liberal arts classes for Daejeon residents.
The theme of the course for this semester is “World and Politics,” which will begin on 13th March and run every Thursday for 6 weeks at KAIST’s International Seminar Room.
This course has been organized to introduce the general public to the current political situation with neighboring countries such as China, Japan and North Korea, as well as the characteristics of multinational companies.
Top experts in the related fields will give lectures. First, Professor Ha-Yong Jung from Kyunghee University will talk on “American liberalism and democracy”; Professor Gyeong-Mo An from Korea National Defense University on “Kim Jeong-Eun and the Future of North Korea--Is the Collapse of North Korea A Reality?” and Ja-Seon Koo, a visiting professor at Korea National Diplomatic Academy on “The Chinese Communist Party during the Xi Jinping Period.”
“With the era of globalization, the political situations in the neighboring countries have both direct and indirect effects on our lives,” said Professor Hyeon-Seok Park who has organized the courses. "These classes will be an opportunity for our citizens to understand and learn about the current affairs in the world.”
Anyone can attend the course, and registration is from March 5th to 9th at the official webpage of KAIST’s Humanities and Social Sciences Department (http://hss.kaist.ac.kr). All the courses are free of charge.
Contact: Department of Humanities and Social Science Research (Tel. 350-4687, E-mail: baobab@kaist.ac.kr)
2014.03.06 View 6958