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KAIST's HUBO Ready for DARPA's Robotics Challenge Trials
When walking on muddy or bumpy roads, the two arms of DRC-HUBO become extra legs, enabling stable and agile movements.
The Humanoid Robot Research Center (HUBO Lab, http://hubolab.kaist.ac.kr) at the Korea Advanced Institute of Science and Technology (KAIST) and Rainbow Co., a spin-off venture company of the university, unveiled a new model of HUBO that will be entered in an international robotics competition scheduled later this year.
The competition is hosted and sponsored by the US Defense Advanced Research Projects Agency (DARPA), which is called the DARPA Robotics Challenge (DRC). Kicked off in October 2012, the DRC’s goal is to spur the development of advanced robots that can assist humans in mitigating and recovering from future natural and man-made disasters.
KAIST’s humanoid robot, HUBO, was originally created by Jun-Ho Oh, a distinguished professor of the Department of Mechanical Engineering, in 2004. Since then, the robot has gone through technological advancements, with the latest version of HUBO II released in 2012. So far, 12 HUBOs have been exported for further studies in robotics to universities, research institutes, and private companies in the US, China, and Singapore.
In tandem with Rainbow Co. (www.rainbow-robot.com), Professor Oh and his research team recently developed DRC-HUBO, which will compete as Team DRC-HUBO led by Drexel University at the DRC trials to be held in December 2013. Team DRC-HUBO is consisted of KAIST and nine US institutions.
DRC-HUBO is designed to perform difficult but essential activities required when responding to disaster scenes. The robot will have to fulfill eight tasks assigned by the DRC at the upcoming event such as driving a utility vehicle, walking across rough terrain, climbing a ladder, and using hand tools.
Unlike the previous models of HUBO, DRC-HUBO boasts several distinctive, enhanced features. Chief among them is the way the robot interacts with the external environment. Without complex sensors installed throughout the body, DRC-HUBO can control each joint of the arms and legs in compliance with the dynamics dictated by the external environment.
For example, when DRC-HUBO is faced with a rock falling from above while climbing up a ladder, the robot’s arms and legs naturally give in to the force of external changes. Accordingly, as the robot dodges the rock, its body and joints smoothly sway to absorb shock so that the fingers can keep a tight grip on the ladder, and the feet are planted firmly on the rail of the ladder, not losing balance.
In addition, DRC-HUBO can switch from bipedal to quadrupedal walking and vice versa. This provides the robot with greater stability to walk on uneven terrain or to climb up a hill. The robot’s arms and legs are elongated to better meet the challenges demanded by the DRC competition. DRC-HUBO’s two arms swing back and forth to form legs when necessary, thereby walking freely backwards and forwards.
The robot has gotten stronger grip as well. The right hand has four fingers (with one triggering finger that operates independently from the other three fingers), and the left hand has three fingers. All three fingers on both hands are actuated synchronously for gripping. The fingers are sophisticated enough to steer the wheel of a vehicle or grab a ladder to climb up, and strong enough to hold 15 lbs in one hand.
“With a full 34 degrees of freedom (DOF), DRC-HUBO stands 4.7 ft tall and weighs 120 lbs. All in all, the robot has been improved and extensively refurbished from the past models of HUBOs to compete at the DRC Trials. It has better vision and coordination. The legs and arms have become stronger,” said Professor Oh.
“Although the robot is still a prototype, it has important capabilities that can be utilized in advancing humanoid robots in general. One example is the way its arms can be used as extra legs to support the robot’s body, offering more flexibility in providing aid to humans.”
2013.07.25 View 13340 -
A magnetic pen for smartphones adds another level of conveniences
Utilizing existing features on smartphones, the MagPen provides users with a compatible and simple input tool regardless of the type of phones they are using.
A doctoral candidate at the Korea Advanced Institute of Science and Technology (KAIST) developed a magnetically driven pen interface that works both on and around mobile devices. This interface, called the MagPen, can be used for any type of smartphones and tablet computers so long as they have magnetometers embedded in.
Advised by Professor Kwang-yun Wohn of the Graduate School of Culture Technology (GSCT) at KAIST, Sungjae Hwang, a Ph.D. student, created the MagPen in collaboration with Myung-Wook Ahn, a master"s student at the GSCT of KAIST, and Andrea Bianchi, a professor at Sungkyunkwan University.
Almost all mobile devices today provide location-based services, and magnetometers are incorporated in the integrated circuits of smartphones or tablet PCs, functioning as compasses. Taking advantage of built-in magnetometers, Hwang"s team came up with a technology that enabled an input tool for mobile devices such as a capacitive stylus pen to interact more sensitively and effectively with the devices" touch screen. Text and command entered by a stylus pen are expressed better on the screen of mobile devices than those done by human fingers.
The MagPen utilizes magnetometers equipped with smartphones, thus there is no need to build an additional sensing panel for a touchscreen as well as circuits, communication modules, or batteries for the pen. With an application installed on smartphones, it senses and analyzes the magnetic field produced by a permanent magnet embedded in a standard capacitive stylus pen.
Sungjae Hwang said, "Our technology is eco-friendly and very affordable because we are able to improve the expressiveness of the stylus pen without requiring additional hardware beyond those already installed on the current mobile devices. The technology allows smartphone users to enjoy added convenience while no wastes generated."
The MagPen detects the direction at which a stylus pen is pointing; selects colors by dragging the pen across smartphone bezel; identifies pens with different magnetic properties; recognizes pen-spinning gestures; and estimates the finger pressure applied to the pen.
Notably, with its spinning motion, the MagPen expands the scope of input gestures recognized by a stylus pen beyond its existing vocabularies of gestures and techniques such as titling, hovering, and varying pressures. The tip of the pen switches from a pointer to an eraser and vice versa when spinning. Or, it can choose the thickness of the lines drawn on a screen by spinning.
"It"s quite remarkable to see that the MagPen can understand spinning motion. It"s like the pen changes its living environment from two dimensions to three dimensions. This is the most creative characteristic of our technology," added Sungjae Hwang.
Hwang"s initial research result was first presented at the International Conference on Intelligent User Interfaces organized by the Association for Computing Machinery and held on March 19-22 in Santa Monica, the US.
In the next month of August, the research team will present a paper on the MagPen technology, entitled "MagPen: Magnetically Driven Pen Interaction On and Around Conventional Smartphones" and receive an Honorable Mention Award at the 15th International Conference on Human-Computer Interaction with Mobile Devices and Services (MobileHCI 2013) to be held in Germany.
In addition to the MagPen, Hwang and his team are conducting other projects to develop different types of magnetic gadgets (collectively called "MagGetz") that include the Magnetic Marionette, a magnetic cover for a smartphone, which offers augmented interactions with the phone, as well as magnetic widgets such as buttons and toggle interface.
Hwang has filed ten patents for the MagGetz technology.
Youtube Links: http://www.youtube.com/watch?v=NkPo2las7wc, http://www.youtube.com/watch?v=J9GtgyzoZmM
2013.07.25 View 9914 -
Technology Developed to Control Light Scattering Using Holography
Published on May 29th Nature Scientific Reports online
Recently, a popular article demonstrated that an opaque glass becomes transparent as transparent tape is applied to the glass. The scientific principle is that light is less scattered as the rough surface of the opaque glass is filled by transparent tape, thereby making things behind the opaque glass look clearer.
Professor Yong-Keun Park from KAIST’s Department of Physics, in a joint research with MIT Spectroscopy Lab, has developed a technology to easily control light scattering using holography. Their results are published on Nature’s Scientific Reports May 29th online edition.
This technology allows us to see things behind visual obstructions such as cloud and smoke, or even human skin that is highly scattering, optically thick materials. The research team applied the holography technology that records both the direction and intensity of light, and controlled light scattering of obstacles lied between an observer and a target image. The team was able to retrieve the original image by recording the information of scattered light and reflecting the light precisely to the other side.This phenomenon is known as “phase conjugation” in physics. Professor Park’s team applied phase conjugation and digital holography to observe two-dimensional image behind a highly scattering wall. “This technology will be utilized in many fields of physics, optics, nanotechnology, medical science, and even military science,” said Professor Park. “This is different from what is commonly known as penetrating camera or invisible clothes.” He nevertheless drew the line at over-interpreting the technology, “Currently, the significance is on the development of the technology itself that allows us to accurately control the scattering of light."
Figure I. Observed Images
Figure II. Light Scattering Control
2013.07.19 View 7817 -
Joint Research Center on EEWS with Hyundai Heavy Industries Plans to Open
The research center will conduct collaborative R&D projects on energy, environment, water, and sustainability for the next five years.Hyundai Heavy Industries (HHI), the world’s largest shipbuilding company, signed an MOU with KAIST for future business development and joint research collaboration.
KAIST and HHI signed an MOU as an agreement to establish the “HHI-KAIST EEWS Research Center (HK Research Center) on June 21st.”
The major mission of the HK Research Center is to build a strong base for creating future businesses through developing fundamental, core technology in the field of EEWS and designing business models based on the new technology.
Toward this goal, HHI will sponsor the R&D budget and operation expenses of the research center for the next five years.
Prior to the signing of the MOU, a delegation from HHI, led by the Vice President, Mr. Si-Young Hwang, visited the Office of EEWS Initiative at KAIST and held a workshop. During the workshop, HHI and KAIST agreed to collaborate in fields such as LNG-propelled ships, solar power generation, energy storage, fuel cells, and CO2 capture.
KAIST has run a EEWS graduate program that receives government grants over the last five years, with a research emphasis on energy, environment, water, and sustainability, which are crucial issues to humankind in the 21st century. The EEWS program achieved 24 core technological developments and educates more than 200 masters- and PhD-degree students annually.
The EEWS program also emphasizes commercializing its research outcomes. Through the annual Business Planning Competition and Investment Drive, there have been eight new companies founded by alumni and professors over the last five years of the program. The HK Research Center will be an excellent foundation for future education and research in EEWS.
Professor Jae-Kyu Lee, the head of the HK Research Center and the director of the EEWS Initiative, said, “This event is a benchmarking example of Industry-KAIST collaboration. We hope that the HK Research Center will be a place for disruptive innovations to translate into creative business opportunities.”
MOU signed for Hyundai Heavy Industries-KAIST EEWS Research Center
2013.07.15 View 7867 -
Prof. Song Chong received the IEEE William R. Bennett Prize Paper Award
The IEEE (Institute of Electrical and Electronics Engineers) Communications Society (ComSoc), a renowned global network of professionals with a common interest in advancing communications technologies, has announced the winner of the 2013 William R. Bennett Prize in the field of communications networking. The prize was given to a Korean research team led by Song Chong, Professor of Electrical Engineering at KAIST and Injong Rhee, Professor of Computer Science at North Carolina State University. In addition, Dr. Minsu Shin, Dr. Seongik Hong, and Dr. Seong Joon Kim of Samsung Electronics Co., Ltd. as well as Professor Kyunghan Lee from Ulsan National Institute of Science and Technology were recognized for their contribution.
The William R. Bennett Prize for communications networking has been awarded each year since 1994 in recognition of the best paper published in any journal financially sponsored or co-sponsored by ComSoc in the previous three calendar years. Only one paper per year is selected based on its quality, originality, scientific citation index, and peer reviews. Among the previous award winners are Robert Gallager of MIT, and Steven Low of the California Institute of Technology, and Kang G. Shin of the University of Michigan.
The Korean research team’s paper, On the Levy-Walk Nature of Human Mobility, was published in the June 2011 issue of IEEE/ACM Transactions on Networking, a bimonthly journal co-sponsored by the IEEE ComSoc, the IEEE Computer Society, and the Association for Computing Machinery (ACM) with its Special Interest Group on Data Communications (SIGCOMM).
In the paper, the research team proposed a new statistical model to effectively analyze the pattern of individual human mobility in daily life. The team handed out GPS (global positioning system) devices to 100 participants residing in five different university campuses in Korea and the US and collected data on their movements for 226 days. The mobility pattern obtained from the experiment predicted accurately how the participants actually moved around during their routines. Since publication, the paper has been cited by other papers approximately 350 times.
The team’s research results will apply to many fields such as the prevention and control of epidemics, the design of efficient communications networks, and the development of urban and transportation system.
The research team received the award on June 10th at the 2013 IEEE International Conference on Communications (ICC) held in Budapest, Hungary, from June 9-13, 2013.
Professor Song Chong
2013.07.06 View 12101 -
Nanofiber sensor detects diabetes or lung cancer faster and easier
Metal-oxide nanofiber based chemiresistive gas sensors offer greater usability for portable real-time breath tests that can be available on smart phones or tablet PCs in the near future.
Daejeon, Republic of Korea, June 11, 2013 -- Today"s technological innovation enables smartphone users to diagnose serious diseases such as diabetes or lung cancer quickly and effectively by simply breathing into a small gadget, a nanofiber breathing sensor, mounted on the phones.
Il-Doo Kim, Associate Professor of Materials Science and Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST), and his research team have recently published a cover paper entitled "Thin-Wall Assembled SnO2 Fibers Functionalized by Catalytic Pt Nanoparticles and their Superior Exhaled Breath-Sensing Properties for the Diagnosis of Diabetes," in an academic journal, Advanced Functional Materials (May 20th issue), on the development of a highly sensitive exhaled breath sensor by using hierarchical SnO2 fibers that are assembled from wrinkled thin SnO2 nanotubes.
In the paper, the research team presented a morphological evolution of SnO2 fibers, called micro phase-separations, which takes place between polymers and other dissolved solutes when varying the flow rate of an electrospinning solution feed and applying a subsequent heat treatment afterward.
The morphological change results in nanofibers that are shaped like an open cylinder inside which thin-film SnO2 nanotubes are layered and then rolled up. A number of elongated pores ranging from 10 nanometers (nm) to 500 nm in length along the fiber direction were formed on the surface of the SnO2 fibers, allowing exhaled gas molecules to easily permeate the fibers. The inner and outer wall of SnO2 tubes is evenly coated with catalytic platinum (Pt) nanoparticles. According to the research team, highly porous SnO2 fibers, synthesized by eletrospinning at a high flow rate, showed five-fold higher acetone responses than that of the dense SnO2 nanofibers created under a low flow rate. The catalytic Pt coating shortened the fibers" gas response time dramatically as well.
The breath analysis for diabetes is largely based on an acetone breath test because acetone is one of the specific volatile organic compounds (VOC) produced in the human body to signal the onset of particular diseases. In other words, they are biomarkers to predict certain diseases such as acetone for diabetes, toluene for lung cancer, and ammonia for kidney malfunction. Breath analysis for medical evaluation has attracted much attention because it is less intrusive than conventional medical examination, as well as fast and convenient, and environmentally friendly, leaving almost no biohazard wastes.
Various gas-sensing techniques have been adopted to analyze VOCs including gas chromatography-mass spectroscopy (GC-MS), but these techniques are difficult to incorporate into portable real-time gas sensors because the testing equipment is bulky and expensive, and their operation is more complex. Metal-oxide based chemiresistive gas sensors, however, offer greater usability for portable real-time breath sensors.
Il-Doo Kim said, "Catalyst-loaded metal oxide nanofibers synthesized by electrospinning have a great potential for future exhaled breath sensor applications. From our research, we obtained the results that Pt-coated SnO2 fibers are able to identify promptly and accurately acetone or toluene even at very low concentration less than 100 parts per billion (ppb)."
The exhaled acetone level of diabetes patients exceeds 1.8 parts per million (ppm), which is two to six-fold higher than that (0.3-0.9 ppm) of healthy people. Therefore, a highly sensitive detection that responds to acetone below 1 ppm, in the presence of other exhaled gases as well as under the humid environment of human breath, is important for an accurate diagnosis of diabetes. In addition, Professor Kim said, "a trace concentration of toluene (30 ppb) in exhaled breath is regarded to be a distinctive early symptom of lung cancer, which we were able to detect with our prototype breath tester."
The research team has now been developing an array of breathing sensors using various catalysts and a number of semiconducting metal oxide fibers, which will offer patients a real-time easy diagnosis of diseases.
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Youtube Link: http://www.youtube.com/watch?v=t_Hr11dRryg
For further inquires:
Il-Doo Kim, Professor of Materials Science and Engineering, KAIST
Advanced Nanomaterials and Energy Laboratory
Tel: +82-42-350-3329
Email: idkim@kaist.ac.kr
Clockwise from left to right: left upper shows a magnified SEM image of a broken thin-wall assembled SnO2 fiber. Left below is an array of breath sensors (Inset is an actual size of a breath sensor). The right is the cover of Advanced Functional Materials (May 20th issue) in which a research paper on the development of a highly sensitive exhaled breath sensor by using SnO2 fibers is published.
This is the microstructural evolution of SnO2 nanofibers as a function of flow rate during electrospinning.
2013.06.20 View 13399 -
International Student Conference (ICISTS-KAIST) to be Held in August
- 300 participants including university students worldwide and renowned speakers expected to gather
- Ideal coexistence of science & technology and society explored under the theme of “Perfect Alliance”
Science & technology and society are at the core of 21st century’s development. ICISTS-KAIST 2013, international conference for university students, seeks ways for the two to coexist harmoniously and is to be held from August 5 to 9 on KAIST campus as well as at Daejeon Convention Center.
ICISTS stands for International Conference for the Integration of Science, Technology and Society. ICISTS-KAIST is a non-profit organization run by KAIST students who are directly engaged in the coordination, planning, finance, public relations, and management of this academic event. The upcoming ninth annual event of ICISTS (www.icists.org) 2013 is centered around the theme, “Perfect Alliance: Coexistence for Human Society.” The conference will last for four nights and five days; scholars and students across various academic backgrounds gather to narrow the gap between fields of study and discuss possible solutions to the problems in today’s society.
The annual conference, ICISTS-KAIST attracts hundreds of participants from all over the world to KAIST, Daejeon and its most recent event last year witnessed discussions among some 300 students from 22 countries hearing the lectures from 40 academics and scholars. This year’s event will welcome the 16-year old inventor, scientist, and cancer researcher Jack Thomas Andraka, the founder of the “One Laptop Per Child” project Walter Bender, Chemistry Nobel Prize laureate Harold Walter Kroto, and many more.
The application period for ICISTS-KAIST 2013 runs from May 20 to July 12, and applications are received through the website at www.icists.org.
ICISTS-KAIST 2013 Promgram Summary
Event Title: International Conference for the Integration of Science, Technology and Society 2013 (ICISTS-KAIST 2013)
Theme: Perfect Alliance: Coexistence for Human Society
Date and Venue: 2013 Aug. 5 (Mon.) ~ Aug. 9 (Fri.), KAIST Campus and Daejeon Convention Center
Host and Organizer: ICISTS KAIST
Sponsor: Korean National Commission for UNESCO, Korea Tourism Organization, Korea Ministry of Education, Science & Technology, KOFST
Session Description:
Keynote Speech - Keynote address on fundamental approach to coexistence
Parallel Session - Multiple simultaneous lecture of delegates’ choice
Group Discussion - Small group discussions among delegates and speakers
Panel Discussion - In-depth and thought-revealing discussion among speakers
Experience Session - First-person experience on relevant technology
Team Project & Poster Fair - Team mission, poster exhibition and evaluation
Subtopics:
- New Values from Coexistence of Science & Technology and Society
- Synergetic Resolution via Coexistence of Science & Technology and Society
- Essential Communication for Coexistence of Science & Technology and Society
Notable Speakers:
- Gretchen Kalonji: Assistant to Director-General at UNESCO
- Sheila Jasanoff: Director of STS Program at Harvard Kennedy School
- Walter Bender: Former Director of MIT Media Lab and One Laptop Per Child- Jack Andraka: 16-year old Cancer Resesarcher
2013.05.31 View 8450 -
KAIST hosts 2013 Wearable Computer Contest
2013 Wearable Computer Contest (WCC) will be held in early November. This year’s contest is hosted by KAIST and sponsored by Samsung Electronics.
Wearable computers are drawing attention in the IT world as a potentially convenient information and communication device for future generations, which are attached to clothing or on the body. As smartphones have grown increasingly more popular, various supporting devices are being developed. The IT industry is targeting wearable computers for future development. The main leaders of the field, Samsung, Apple (i-Watch) and Google (Google Glasses) are joining the race for its development.
European and US firms halted their research in wearable computers in the 2000s, but there has been a great burst of interest recently. Korea has been consistently taking on wearable computer research since 2003 and held the Wearable Computer Contest for the last nine years. Since 2005, the contest aims to promote leading edge technological research and Intellectual Property (IP) as well as cultivate a professional workforce in Korea. The contest has promoted world class research in the field of wearable computer technology.
Moreover, KAIST has increased support for its competing teams through Samsung sponsorship and is considering applying the technology from the contest into Samsung products. Winning teams receive 1,500,000 Korean won and Samsung smart IT devices to produce an actual wearable computer. KAIST has increased the number of members who can participate in the competing teams in the finals from 10 to 15 to provide more opportunities to develop wearable computers.
With the theme “Smart IT: Any-information for Anybody,” the 2013 Wearable Computer Contest requires competing teams to suggest an innovative idea which combines IT and fashion for wearable computers. Teams that pass the paper and presentation evaluation go on to the finals, where 15 teams will have four months of production period for the final evaluation in November.
The final teams also receive systematic education on ubiquitous computing, wearable computer platforms, and Human-Computer Interaction (HCI).
The Wearable Computer Contest is holding an ideas contest pitched in a poster format. This contest evaluates proposals for wearable computers, and there is no requirement to enter the rest of the contest. Anyone can compete without having to physically make the product.
More information on the registration and the contest can be found at http://www.ufcom.org/.
2013.04.30 View 7264
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Popular Science May 2013: Online Electric Vehicle (OLEV) Introduced as Part of Smart Roads
Popular Science (PopSci), a famous American monthly magazine publishing popular science articles for general readers on science and technology subjects, introduced KAIST’s Online Electric Vehicle (OLEV) in its latest issue of May 2013. For the article, please see the attachment.
2013.04.25 View 7098 -
Award Winning Portable Sound Camera Design
- A member of KAIST’s faculty has won the “Red Dot Design Award,” one of three of the most prestigious design competitions in the world, for the portable sound camera.
KAIST’s Industrial Design Professor Suk-Hyung Bae’s portable sound camera design, made by SM Instruments and Hyundai, has received a “Red Dot Design Award: Product Design,” one of the most prestigious design competitions in the world.
If you are a driver, you must have experienced unexplained noises in your car. Most industrial products, including cars, may produce abnormal noises caused by an error in design or worn-out machinery. However, it is difficult to identify the exact location of the sound with ears alone.
This is where the sound camera comes in. Just as thermal detector cameras show the distribution of temperature, sound cameras use a microphone arrangement to express the distribution of sound and to find the location of the sound. However, existing sound cameras are not only too big and heavy, their assembly and installation are complex and must be fixed on a tripod. These limitations made it impossible to measure noises from small areas or the base of cars.
The newly developed product is an all-in-one system resolving the inconvenience of assembling the microphone before taking measurements. Moreover, the handle in the middle is ergonomically designed so users can balance its weight with one hand. The two handles on the sides work as a support and enable the user to hold the camera in various ways.
At the award ceremony, Professor Suk-Hyung Bae commented, “The effective combination of cutting edge technology and design components has been recognized.” He also said, “It shows the competency of the KAIST’s Department of Industrial Design, which has a high understanding of science and technology.”
On the other hand, SM Instruments is a sound vibration specialist company which got its start from KAIST’s Technology Business Incubation Centre in 2006 and earned its independence by gaining proprietary technology in only two years. SM Instruments is contributing to developing national sound and vibration technology through relentless change and innovation. ;
Figure 1: Red Dot Design Award winning the portable sound camera, SeeSV-S205
Figure 2: Identifying the location of the noise using the portable sound camera
Figure 3: The image showing the sound distribution using the portable sound camera
2013.04.09 View 19012 -
New Structural Insight into Neurodegenerative Disease
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. Mutations in Ataxin-1 cause the neurological disease, Spinocerebella Ataxia Type 1 (SCA1), which is characterized by a loss of muscular coordination and balance (ataxia), as is seen in Parkinson’s, Alzheimer’s, and Huntington’s diseases.
SCA1-causing mutations in the ATAXIN1 gene alter the length of a glutamine stretch in the Ataxin-1 protein. The research team provides the first structural insight into the complex formation of ATAXIN-1 with its binding partner, Capicua (CIC). The team, led by Professor Ji-Joon Song from the Department of Biological Sciences at KAIST, solved the structure of Ataxin-1 and CIC complex in atomic level revealing molecular details of the interaction between Ataxin-1 and CIC.
Professor Song explained his recent research work,
“We are able to see the intricate process of complex formation and reconfiguration of the two proteins when they interact with each other. Our work, we expect, will provide a new therapeutic target to modulate SCA1 neurodegenerative disease.”
Understanding structural and molecular details of proteins at the atomic level will help researchers to track the molecular pathogenesis of the disease and, ultimately, design targeted therapies or treatments for patients, rather than just relieving the symptoms of diseases.
Professor Song’s research paper, entitled “Structural Basis of Protein Complex Formation and Reconfiguration by Polyglutamine Disease Protein ATAXIN-1 and Capicua,” will be published in the March 15th issue of Genes & Development (www.genesdev.org).
Complex Formation and Reconfiguration of ATAXIN-1 and Capicua
The complex formation between a polyglutamine disease protein, ATXIN-1 and the transcriptional repressor Capicua (CIC) plays a critical role in SCA 1 pathogenesis. The image shows that the homodimerization of ATXIN-1 (yellow and red) is disrupted upon binding of CIC (blue). Furthermore, the binding of CIC to the ATXIN-1 induces a new form of ATXIN-1 dimerization mediated by CICs (ATXIN-1 AXH domains are shown in yellow and red, and CIC peptides shown in blue and white).
2013.04.02 View 8533 -
Ligand Recognition Mechanism of Protein Identified
Professor Hak-Sung Kim
-“Solved the 50 year old mystery of how protein recognises and binds to ligands”
- Exciting potential for understanding life phenomena and the further development of highly effective therapeutic agent development
KAIST’s Biological Science Department’s Professor Hak-Sung Kim, working in collaboration with Professor Sung-Chul Hong of Department of Physics, Seoul National University, has identified the mechanism of how the protein recognizes and binds to ligands within the human body.
The research findings were published in the online edition of Nature Chemical Biology (March 18), which is the most prestigious journal in the field of life science.
Since the research identified the mechanism, of which protein recognises and binds to ligands, it will take an essential role in understanding complex life phenomenon by understanding regulatory function of protein.
Also, ligand recognition of proteins is closely related to the cause of various diseases. Therefore the research team hopes to contribute to the development of highly effective treatments.
Ligands, well-known examples include nucleic acid and proteins, form the structure of an organism or are essential constituents with special functions such as information signalling.
In particular, the most important role of protein is recognising and binding to a particular ligand and hence regulating and maintaining life phenomena. The abnormal occurrence of an error in recognition of ligands may lead to various diseases.
The research team focused on the repetition of change in protein structure from the most stable “open form” to a relatively unstable “partially closed form”.
Professor Kim’s team analysed the change in protein structure when binding to a ligand on a molecular level in real time to explain the ligand recognition mechanism.
The research findings showed that ligands prefer the most stable protein structure. The team was the first in the world to identify that ligands alter protein structure to the most stable, the lowest energy level, when it binds to the protein.
In addition, the team found that ligands bind to unstable partially-closed forms to change protein structure.
The existing models to explain ligand recognition mechanism of protein are “Induced Custom Model”, which involves change in protein structure in binding to ligands, and the “Structure Selection Model”, which argues that ligands select and recognise only the best protein structure out of many. The academic world considers that the team’s research findings have perfectly proved the models through experiments for the first time in the world.
Professor Kim explained, “In the presence of ligands, there exists a phenomenon where the speed of altering protein structure is changed. This phenomenon is analysed on a molecular level to prove ligand recognition mechanism of protein for the first time”. He also said, “The 50-year old mystery, that existed only as a hypothesis on biology textbooks and was thought never to be solved, has been confirmed through experiments for the first time.”
Figure 1: Proteins, with open and partially open form, recognising and binding to ligands.
Figure 2: Ligands temporarily bind to a stable protein structure, open form, which changes into the most stable structure, closed form. In addition, binding to partially closed form also changes protein structure to closed form.
2013.04.01 View 10372