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Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11699 -
Biomimetic reflective display technology developed
Professor Shin Jung Hoon
The bright colors of a rainbow or a peacock are produced by the reflection and interference of light in transparent periodic structures, producing what is called a structural color. These colors are very bright and change according to the viewing angle. On the other hand, the wings of a morpho-butterfly also have structural colors but are predominantly blue over a wide range of angles. This is because the unique structure of the morpho-butterfly’s wings contains both order and chaos.
Professor Shin Jung Hoon’s team from the Department of Physics and the Graduate School of Nanoscience and Technology at KAIST produced a display that mimics the structure of the morpho-butterfly’s wings using glass beads.
This research successfully produced a reflective display (one that reflects external light to project images), which could be used to make very bright displays with low energy consumption. This technology can also be used to make anti-counterfeit bills, as well as coating materials for mobile phones and wallets.
The structure of the morpho-butterfly’s wings seems to be in periodic order at the 1-micrometer level, but contains disorder at the 100-nanometer level. So far, no one had succeeded in reproducing a structure with both order and disorder at the nanometer level.
Professor Shin’s team randomly aligned differently sized glass beads of a few hundred nanometers to create chaos and placed a thin periodic film on top of it using the semiconductor deposition method, thereby creating the morpho-butterfly-like structure over a large area.
This new development produced better color and brightness than the morpho-butterfly wing and even exhibited less color change according to angle. The team sealed the film in thin plastic, which helped to maintain the superior properties whilst making it more firm and paper-like.
Professor Shin emphasized that the results were an exemplary success in the field of biomimetics and that structural colors could have other applications in sensors and fashion, for example.
The results were first introduced on May 3rd in Nature as one of the Research Highlights and will be published in the online version of the material science magazine, Advanced Materials.
This research was jointly conducted by Professor Shin Jung Hoon (Department of Physics / Graduate School of Nanoscience and Technology at KAIST), Professor Park NamKyoo (Department of Electrical and Computer Engineering at Seoul National University), and Samsung Advanced Institute of Technology. The funding was provided by the National Research Foundation of Korea and the Ministry of Education, Science and Technology as part of the World Class University (WCU) project.
Figure 2. The biomimetic film can express many different colors
Figure 3. The biomimetic diplay and a morpho-butterfly
2012.05.07 View 13397 -
Creation of Synthetic Antibodies: Professor Hak Seong Kim
Synthetics antibodies which can replace antibodies from humans used as ingredients of medicines have been developed. It can increase the costs to 1/100 of the current costs and is much easier to develop. It is expected that the development period will be shortened from 10 years to 5.
Prof. Hak Seong Kim from the Biology department of KAIST conducted a joint research with Prof. Dong Seob Kim to reconstruct proteins and has succeeded.
The synthetic antibody displays much strength in terms of its productivity, structural formation, and bonding capability, and is thus regarded as an ideal protein. It can replace the antigens that are currently in use. It is expected that Korea will therefore be able to lead the world market for protein medicines which is a 192trillion won industry.
The original antibody has been used for not only treating diseases, but also for various other applications in the fields of medical sciences and biology. However, it is produced through a very complex process involving the incubation of animal cells, and is therefore very expensive. Also, most antibodies are already patented by more developed countries, so a high royalty fee must be paid.
Because of this, many countries including Korea has been concentrating on developing biosimilars copying the antibody medicines for which the patents have already expired. This causes Korea to be behind in the development of antibody protein pharmaceuticals.
Prof. Kim’s research team has focused on the face that the protein existing in some eels are not antibodies but functions as one, and has been successful in developing a synthetic antibody.
The synthetic antibody can be mass produced from the colon bacillus, which allows it to be produced at 1/100 the original cost. It is in a module structure which allows the structuring of the antibody into the desired structure, enabling it to be developed into a protein-based medicine within 5 years.
Together with this, the coherence with the important antigens can be easily controlled, thus allowing for highly effective treatments, less side-effects, high security regarding heat and pH, and the immunogen levels being negligeable. This suggests a very high rate of the antibody being converted into a protein based medication.
The synthetic antibody technology has been tested as a sample for the cure for lung diseases and rheumatism and has been proven to be appropriate. Animal testing will be conducted soon.
Prof Kim said “The original antibodies had a small area allowing the bonding with antibodies, creating barriers for raising bonding strength and structuring. The newly created antibody carries only the strengths and will become a new protein based medicine purely created by Korean technology to replace the antibodies currently used in medications.”
Furthermore, he added that, “The synthesized antibody structuring and designing technology will be widely used in the areas of detecting, diagnosing, and analyzing diseases.”
At the same time, this research result has been published in the Feb 10th issue of the PNAS, and has been supported by the future promising pioneer business program held by the Ministry of Education and Technology.
2012.04.04 View 10231
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Inexpensive Separation Method of Graphene Developed
The problem with commercializing graphene that is synthesized onto metals over a wide area is that it can not be separated from the metal. However, a groundbreaking separation technology which is both cheap and environment friendly has been developed.
Prof. Taek soo Kim and Prof. Byung Jin Cho"s research teams have conducted this research under the support of the Global Frontier program and Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research results have been posted on the online news flash of Nano Letters on februrary 29th. (Thesis title: Direct Measurement of Adhesion Energy of Monolayer Graphene As-Grown on Copper and Its Application to Renewable Transfer Process)
The research has generated exact results on the interfacial adhesive energy of graphene and its surface material for the first time. Through this, the catalyst metal are no longer to be used just once, but will be used for an infinite number of times, thereby being ecofriendly and efficient.
Wide area graphine synthesized onto the catalyst meatal are used in various ways such as for display and for solar cells. There has been much research going on in this field. However, in order to use this wide area graphene, the graphene must be removed from the catalyst metal without damage.
Until now, the metal had been melted away through the use of chemical substances in order to separate the graphene. However, this method has been very problematic. The metal can not be reused, the costs are very high, much harmful wastes were created in the process of melting the metals, and the process was very complicated.
The research teams of Professors Taek Su Kim and Byung Jin Cho measured the interfacial adhesive energy of the synthesized graphene and learned that it could be easily removed.
Also, the mechanically removed graphene was successfully used in creating molecular electronic devices directly. This has thus innovatively shortened the graphene manufacturing process. Also, it has been confirmed that the metalic board can be reused multiple times after the graphene is removed. A new, ecofriendly and cost friendly method of graphene manufacturing has been paved.
Through this discovery, it is expected that graphene will become easier to manufacture and that the period til the commercialization date of graphene will therefore be greatly reduced
Prof. Cho stated " This reserach has much academical meaning significance in that it has successfully defined the surfacial adhesive energy between the graphene and its catalyst material and it should receive much attention in that it solved the largest technical problem involved in the production of graphene.
2012.04.04 View 12608
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New Era for Measuring Ultra Fast Phenomena: Atto Science Era
Domestic researchers successfully measured the exact status of the rapidly changing Helium atom using an atto second pulse. Thanks to this discovery, many ultrafast phenomena in nature can now be precisely measured. This will lead to an opening of a new "Atto Science" era.
Prof. Nam Chang Hee led this research team and Ph.d Kim Kyung Taek and Prof. Choi Nak Ryul also participated in this research. They have conducted the research under the support of the Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research result was published in the prestigious journal "Physical Review Letters" on March 2nd. (Title: Amplitude and Phase Reconstruction of Electron Wave Packets for Probing Ultrafast Photoionization Dynamics)
Prof. Nam Chang Hee"s research team used atto second pulse to measure the ultrafast photoionization.
His team used atto second X-ray pulse and femto second laser pulse to photoionize Helium atoms, and measure the wave speed of the produced electron to closely investigate the ultrafast photoionization process.
Atom"s photoionization measurement using an atto second pulse was possible using the research team"s high-energy femto second laser and high-performance photo ion measurement device. This research team succeeded in producing the shortest 60 atto second pulse in the world using high-harmonic waves.
The research team used high-power femto second laser to produce atto second high-harmonic pulse from argon gas, used this to photoionize Helium atoms, and measured the ultrafast photoionization of the atoms.
Prof. Nam Chang Hee said, "This research precisely measured the exact status of rapidly changing Helium atoms. I am planning to research on measuring the ultrafast phenomena inside atoms and molecules and controlling the status of the atoms and molecules based on the research result."
2012.04.04 View 9594
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KAIST Confers Honorary Degree to CMU President Cohon
By DongJae Lee
The KAIST Herald Staff Reporter
On February 24, Dr. Jared L. Cohon, President of Carnegie Mellon University (CMU), visited KAIST to receive an honorary degree in science and technology and gave a lecture to the university’s students. Dr. Cohon is the eighth president of CMU and has held numerous other public and university positions. During his presidency, CMU has expanded globally and now takes part in joint programs around the world, including those with universities in Korea, Australia, India and Qatar. KAIST and CMU have been collaborating since 2005 in research projects, student and faculty exchange and dual degree programs. Before the 2012 Commencement Ceremony, Dr. Cohon met with The KAIST Herald and other news agencies for an interview.
The interview started with Dr. Cohon giving a brief introduction of CMU. Like KAIST, CMU has a small but special composition and is dedicated to science and technology as well as business and the fine arts. CMU, founded in 1900, is also relatively young by US standards but has nonetheless grown into a world-class university. The power behind this rapid growth can be expressed by four key values: innovation and change, problem-solving, interdisciplinary cooperation, and hard work. The slogan “My heart is in the work” clearly expresses the values of CMU.
One interesting aspect of CMU is its fine arts and business fields. While CMU is dedicated to science and technology, it also has many respected alumni in the aforementioned fields including Andy Warhol, a leading figure in pop art, and Randy Pausch, the author of The Last Lecture. CMU alumni have together won 6 Academy Awards, 22 Emmy Awards, over 100 Tony Awards and 20 Nobel Prizes.
Regarding CMU’s joint projects with KAIST, as well as student and faculty exchanges, Dr. Cohon mentioned joint Ph.D. programs in Civil and Environmental Engineering and Mechanical Engineering and a joint Master’s program in Software Engineering. Currently, the Civil and Environmental Engineering joint Ph.D. program has one participant and the Software Technology Institute joint Master of Software Engineering program has 6 participants.
Dr. Cohon mentioned that receiving an honorary degree in KAIST is a tremendous honor and that he is grateful to be recognized by such a wonderful university like KAIST.
2012.03.23 View 9911 -
Annual Future Knowledge Service International Symposium
Knowledge Service Research preparing for the future knowledge based society has been academically publicized.
The First Annual Future Knowledge Service International Symposium was held in COEX Grand Ball Room Hall by KAIST’s department of Knowledge Service Engineering.
Knowledge Service Engineering is a core component to the future knowledge based society and is the convergent result of decision making, recognition sciences, artificial intelligence, IT, and other knowledge management technologies from each of the industries. Therefore Knowledge Service Engineering will innovate the cooperation and communication between humans and machines thereby forming the center point of the development of knowledge society.
The symposium was attended by 9 important figures from domestic and foreign academia, government representative, and key figures from industries. The symposium was based around debates concerning the role of the Knowledge Service Engineering in the future knowledge based society.
The key note speaker was Chairman of Korea Science and Technology Information Research Institute Park Young Suh and the theme of the speech was ‘Change in Information Environment and Knowledge Service’.
Director of National IT Industry Promotion Agency Kang Hyun Gu gave a lecture on the topic of ‘Important Knowledge Service Policies by National IT Industry Promotion Agency’. And from industry experts, Bradley K. Jensen (Manager of Microsoft Industry-Education Cooperation), Lee Kang Yoon (Research Director at IBM), Choi Yoon Shik (Head of Asia Future Human Resource Institute) proposed a direction for research and gave their account on recent trends of knowledge service from the perspective of onsite experience.
Academic experts like Fred D. Davis (Professor at State University of Arkansas), Jussi Kantola (Professor at KAIST), Kim Young Gul (Professor at KAIST Management University), Yoon Wan Chul (Professor at KAIST Knowledge Service Engineering) gave the recent trends in academic research.
The symposium was held in 3 sessions: ▲Policy of Korean Government ▲Academic Research Trend ▲Recent Trend and Application.
More information can be found at http://kss.kaist.ac.kr
2012.01.31 View 8435
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KAIST Ph.D Mihyun Jang Employed as Professor at Technische Universitat Graz
A Ph.D purely from Korea has been employed as a professor at Technische Universitat Graz.
This is the news of Prof.Mihyun Kang (39) who has graduated from KAIST’s mathematics department. Prof.Kang has transferred on January 2012.
KAIST explained that “it’s the first time for a mathematics Ph.D from Korea has been employed abroad.”
Technische Universitat Graz of Australia is ranked the top third university within the country. It is a global university with 1,700 students from 78 different countries out of its 11,000 students.
Prof. Kang researched mainly theories of combination including random graphing theories, analytical combination theories, and probabilistic combination theories. She has been employed as a lifetime professor through open recruitment where she competed with others through academic debates and interviews.
Technische Universitat Graz valued Prof. Kang’s research highly made her the department head of the ‘Optimization and Discrete Mathematics department’ to create an environment where she could continuously research.
Prof. Kang graduated from Jeju university majoring math educations and did her graduate studies in KAIST. She is a purely ‘Korean’ Ph.D. After her studies, she worked for Germany’s Humboldt University and Freie Universitat Berlin. In 2007, she was able to be employed as a professor in Germany, and in 2008, she was chosen as a Heisenberg fellow.
Prof. Kang who had her research achievements recognized in Germany and Austria was also offered seat as professor in Ludwig Masximilan University of Germany and Alpenadria University in Austria, but chose Technische Universitat Graz.
2012.01.31 View 10228
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Quantum Mechanical Calculation Theory Developed
An Electron Density Functional Calculation Theory, based on the widely used quantum mechanical principles and yet accurate and with shortened calculation period, was developed by Korean research team.
*Electron Density Functional Calculation Theory: Theory that proves that it is possible to calculate energy and properties with only simple wave equations and electron densities.
The research was conducted by Professor Jeong Yoo Sung (Graduate School of EEWS) and Professor William Goddard with support from WCU Foster Project initiated by Ministry of Education, Science and Technology and Korea Research Foundation. The result was published in the Proceedings of the National Academy of Sciences Journal.
The research team corrected the error when performing quantum calculations that arises from the length of calculation time and incorrect assumptions and developed a theory and algorithm that is more accurate and faster. The use of wave equations in quantum mechanical calculations results in high accuracy but there is a rapid increase in calculation time and is therefore difficult to implement in large molecules with hundreds, or thousands of atoms. By implementing a low electron density variable with relatively less calculation work, the size of calculable molecule increases but the accuracy decreases.
The team focused on the interaction between electrons with different spins to improve upon the speed of calculation in the conventional accurate calculation. The team used the fact that the interaction between electrons with different spins increases as it comes closer together in accordance with the Pauli’s Exclusion Principle.
In addition the interaction between electrons are local and therefore can ignore the interactions between far away electrons and still get the total energy value. The team also took advantage of this fact and developed the algorithm that decreased calculation time hundredth fold.
Professor Jeong commented that, “So far most of the domestic achievements were made by focusing on integrative researches by calculation science and material design communities but these involved short time frames. In areas that required lengthy time frames like fundamentals and software development, there was no competitive advantage. However this research is significant in that a superior solution was developed domestically”.
2012.01.31 View 10277
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 8797
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MOU: KAIST-Korea Internet & Security Agency
KAIST signed a MOU with the Korea Internet & Security Agency for the development of IT and International Security.
As a result of the MOU interaction in ▲Exchange of personnel and materials for cooperative research for information protection ▲Information protection policy and technology ▲Education and training for developing information protection personnel, will be increased.
Director of Cyber Security Research Center Joo Dae Joon commented, “Cyber-attack on national infrastructure like DDOS attacks can threaten the nation’s system” and that “the two institutes will establish a response system against cyber-attacks and train experts in information protection”.
2012.01.31 View 6920
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Bio Pharmaceutical Business Center: Now Open
The Signboard Hanging Ceremony for the Bio Pharmaceutical Business Center for the Integrated Research for the field of Bio Pharmaceutics. 150 representatives from various bio pharmaceutics related businesses and institutes were present for this ceremony.
The Ministry of Education, Science and Technology placed the Molecular Process research team, Personalized Drug Delivery Medium research team, and the newly formed Cancer Cell Detection using Blood research team at the Bio Pharmaceutical Business Center at KAIST.
2012.01.31 View 7973