Chemistry
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KAIST Professor Exposes Structural Dynamics of Protein in Solution
-- Dr. Hyot-Cherl Ihee"s 3-Year Research Is Valuable in Pharmaceutical Application
Prof. Hyot-Cherl Ihee and his team at the Department of Chemistry, KAIST, has successfully unveiled the structural dynamics of protein in solution as a result of more than three years" research work.
Nature Methods, a sister publication of the authoritative science magazine Nature, published the treatise, titled "Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering" in its Sept. 22 online edition. The research paper will be carried in the magazine"s printed version in its October edition, according to Dr. Lee who is its correspondence author.
In May 2005, Prof. Ihee successfully photographed the structural dynamics of protein in solid state and his findings were published in the Proceedings of National Academy of Science of the United States. As protein normally exists in human body in solution, not in solid state, he directed his research to developing the technology to capture protein"s dynamics in resolved state.
In July that year, Prof. Ihee succeeded in measuring the structural changes of simple organic molecules in real time. He further developed the technology to uncover the structural dynamics of hemoglobin, myoglobin and cytochrome C.
Prof. Ihee"s research, helped with the Education-Science-Technology Ministry"s Creative Research Promotion Fund, can be applied to new pharmaceutical development projects as well as nanotechnology development, according to KAIST officials.
Prof. Ihee who earned his doctorate at California Institute of Technology in 1994 began teaching at KAIST in 2003. He won the Young Scientist Award given by the Korean government in 2006.
2008.09.22 View 14115 -
Professor Jie-Oh Lee of the Department of Chemistry of KAIST
Professor Jie-Oh Lee of the Department of Chemistry of KAIST was selected as the "KAIST Man of the Year."
Lee was cited for his successful identifying of the three-dimensional structure of protein that causes sepsis. His research is expected to contribute greatly to the development of medicines for immune system treatment.
The prize was given by KAIST President Suh Nam Pyo at the New Year"s ceremony on Jan. 2, 2008 at the KAIST auditorium.
Professor Lee published a series of research papers in Science, one of the world"s most prestigious scientific journals. Most recently, Lee was awarded the "Scientist of the Year" prize by the Korean Science Reporters Association.
2008.01.02 View 14721 -
Professor Jie-Oh Lee awarded 'Scientist of the Year'
Professor Jie-Oh Lee of the Department of Chemistry was awarded the ‘Scientist of the Year’ prize for identifying the three-dimensional structure of protein that causes sepsis, and it was announced by the Korean Science Reporters Association (KOSRA) on November 26th.“Humans have about 30,000 different kinds of proteins, and they all have different structures, just like our faces,” said Professor Lee. “It is extremely helpful to know the three-dimensional shape of proteins when you are trying to understand what their functions in an organism are and trying to develop medicine for them.”
When looking for the three-dimensional structure, protein must first be crystallized and radiated with x-ray, so that reflected x-ray can be interpreted. The three-dimensional structure of sepsis immunity proteins TLR1-TLR2 and TLR4-MD2 could not be found until now because they would not even crystallize.
“I began to doubt if it was even possible to crystallize them because we went through so many failures,” reflected Professor Lee.
In August of last year, after about three years of research, the team finally came up with a new idea. The team decided to ‘stick’ the sepsis immunity protein to protein that easily crystallizes. If the combined structure of sepsis immunity protein and the known protein could be identified, the structure of sepsis immunity protein would be a combined structure subtracted by the known structure.
The three-dimensional structure was obtained with x-ray radiation from combined protein crystal. The combined protein was derived from an insect cell with altered DNA.
“This method seems very simple but no one ever tried it or no one ever succeeded in it,” said Professor Lee.
The result was a horseshoe shaped protein structure. The research team also expects the new protein-combining technology to contribute to the development of a new immune system treatment medicine.
The prize-awarding ceremony was held on November 26th in an event hosted by the Korean Hospital Association.
Also, Professor Ryong Ryoo of the Department of Chemistry was selected as the National Scientist last month.By KAIST Herald on November, 2007
2007.12.21 View 14222 -
Professor Churchill listed on international biographical dictionary
Professor Churchill listed on international biographical dictionary
Professor David G. Churchill (Department of Chemistry) is listed in Who’s Who in the World in its edition for 2007, international biographical dictionary published by Marquis Who’s Who.
Professor Churchill majored in Organometallic Chemistry and Chemistry of Complex at Colombia University in U.S. and began lectures at KAIST Chemistry department in July 2004.
Professor Churchill has presented 56 papers as member of the American Chemical Society and the Korea Chemical Society and is recognized for his excellent research performances. Recently, he is studying on a method to sense and counteract various toxic nervous substances by bonding them with metals.
2006.11.08 View 17511 -
Professor Ryong Ryoo, selected as a scientist wished to resemble and to be 2006
Professor Ryong Ryoo, selected as a scientist wished to resemble and to be 2006
Professor Ryong Ryoo (Department of Chemistry) was selected as a scientist wished to resemble and to be 2006.
Professor Ryoo developed in 2000 world’s first nanoporous carbon material in which numberless several nanometer-sized holes were drilled. The development of this nanoporous material was introduced by international scientific journal NATURE in 2000 and 2001 and expected to contribute to the progress of mankind through the development of high efficiency fuel cell or ultra-light computer. Professor Ryoo also developed a new technology that can considerably improve the catalyst activation and stability of ‘Zeolite’, a main catalyst in the petrochemical industry, which was introduced by NATURE materials. The above achievements qualified Professor Ryoo for the selection.
‘Scientists wished to resemble and to be 2006’ were selected among scientists showing vigorous activities in the science and technology circle on the basis of their recent achievements, etc. by the Ministry of Science and Technology and the Korea Science Foundation, and total 10 scientists qualified to be the model of children and the youth were announced on August 24.
2006.09.06 View 15814