sensor
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New Technology Developed for Analysis of New Drugs by Using Smart Nano-Sensors
Doctor Sang-Kyu Lee
Doctor Sang-Kyu Lee of the Department of Biological Sciences, KAIST, has developed the technology that allows biological nano particles to be implanted into human cells for monitoring the effect of new drugs in real time from within the cell. It is expected that this technology will boost the ability to weigh the effects and properties of a new drug more quickly and accurately.
Conventionally, the candidate drug was injected into the human body, and then its cells are extracted to analyze the effects of the drugs. The problem with this method was that the cells were analyzed at a ‘dead’ state which made it incredibly difficult to find candidate substances due to uncontrollable side effects. This made the development of new drugs very difficult despite the large costs and efforts invested into its development.
The research team latched onto the idea that nanoparticles can connect to form a large complex. The complex acts as a nanosensor which allows for real time observation of drug target and the drug itself binding.
The team named the nanosensor technology ‘InCell SMART-i’ and was named ‘Hot Paper’ of the September edition of ‘Angewandte Chemie International Edition’ magazine, a world famous Chemistry Magazine.When a new drug injected into the human body, the drug and drug targets are gradually combined, and the smart nanosensor detects in real time the effect of the new drug as shown in the pictures above (shaded spot).
2011.09.19 View 9026 -
Professor Choi Han Lim receives Automatica Applications Paper Price
Professor Choi Han Lim of the Department of Aerospace received ‘Automatica Applications Paper Prize’ for the first time ever for a Korean.
Professor Choi published a paper in the Automatica magazine with the topic of ‘Continuous Trajectory Planning of Mobile Sensors for Informative Forecasting’.
Professor Choi dealt with most efficient measuring methods for mobile sensor platforms thereby improving the performance of anticipating environmental changes and proposed key theories for problem solving and also an efficient algorithm.
The research was conducted in cooperation with MIT Department of Aerospace Professor Jonathan How with the support of the National Science Foundation.
Automatica
Journal published by the International Federation of Automatic Control and has been awarding the Automatica Paper Prize every three years.
2011.05.31 View 7807 -
Artificial Spore Production Technology Developed
The core technology needed in the development of ‘biosensors’ so crucial in diagnosing illnesses or pathogens was developed by Korean research team.
KAIST’s Professor Choi In Seung of the department of Chemistry developed the technology that allows for the production of Artificial Spore by selectively coating a live cell.
In the field of engineering the problem in developing the next generation bio sensor, the cell based sensor, was that it was difficult to keep a cell alive without division for a long time. Once a cell is taken out of the body, it will either divide or die easily.
Professor Choi’s research team mimicked the spore, which has the capability to survive harsh conditions without division, and chemically coated a live cell and artificially created a cell similar to that of a spore.
The physical and biological stabilities of the cell increased by coating an artificial shell over the yeast cell. The shell is composed with a protein similar to that of the protein that gives mussels its stickiness. In addition by controlling the thickness of the shell, the division rate of the yeast can be controlled.
Professor Choi commented that this technology will serve as the basis for the single cell based biosensor.
The research was conducted together with Professor Lee Hae Shin of KAIST department of Chemistry and Professor Jeong Taek Dong of Seoul National University’s department of Chemistry and was published as the cover paper of ‘Journal of the American Chemical Society’.
2011.04.01 View 11887
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Professor Young-Ho Cho elected as head of international academic conference
KAIST’s Professor Young-Ho Cho of the Department of Bio and Brain Engineering was appointed as the head of the PowerMems (Power Micro Electro Mechanical Systems) symposium to be held at Se-Jong Hotel in Seoul from November 15-18, 2011.
Professor Jo is America’s first engineering doctor in the field of MEMS and is the founding member of the BSAC (Berkeley Sensor and Actuator Center), the start of the MEMS technology.
PowerMEMS is the core of green growth and next generation energy production. It focuses on harvesting energy from minute vibrations or renewable energy sources such as sunlight or plants to harvest and store energy via micro or even nano size systems.
The symposium was first held in 2000, and it is where leading experts in the field share papers on the production and harvesting energy in the micro scale.
2011.01.14 View 10375 -
Prof. Park to Receive HP's Annual Innovation Research Award
Prof. In-Kyu Park of the Department of Mechanical Engineering, KAIST, has been will receive an award from Hewlett-Packard"s second annual Labs Innovation Research Program, university authorities said on Wednesday (July 8).
Prof. Park was chosen as the winner of the research award for his paper entitled "Eco-friendly nanomanufacturing for intelligent environment sensing applications."
Sixty projects from 46 universities in 12 countries were selected as the recipients of the awards from HP Labs, the company"s central research arm. The program is designed to create opportunities for colleges, universities and research institutes to conduct collaborative research with HP.
HP Labs Innovation Research Awards provide project funding of up to $100,000 for one year to each of the chosen academic institutions, which is renewable for up to three years based on research progress and HP business requirements.
Prof. Park has conducted joint researches on nanoimprinting, nanosensors, and nanoelectronics with HP"s Information and Quantum Systems Lab since 2005. Starting from the later half of 2009, he is to receive research grants under the industry-academia cooperation program of the world"s information technology giant firm.
2009.07.09 View 12791 -
Korean Researchers Develop Skin-Like Tactile Sensor
THE KOREA TIMES2005.1.31(Mon)
A South Korean scientific research center said Sunday that it has developed a tactile sensor capable of functioning like human skin.
The left picture shows the letters of the Korea Advanced Institute of Science and Technology (KAIST) caught through a tactile sensor functioning like human skin and the right picture is its enlarged image. Scientists from KAIST developed the precision tactile sensor with 1-millimeter spatial resolution.
The tactile sensor is made of polydimethylsiloxane, a synthetic rubber, and has a 1-millimeter spatial resolution capability, the Korea Advanced Institute of Science & Technology (KAIST) said.
``Many tactile sensors have been developed so far, but ours has the highest spatial resolution capability, flexibility, softness and extensibility,’’ said Lee Hyung-kyu, who led the development project.
Late last year, the University of Tokyo unveiled a tactile sensor with a spatial resolution capability of 2 millimeters.
Lee said his team will announce the results of their research at an international conference on micro-electro-mechanical systems, to be held early next month in the U.S. city of Miami.
The new sensor is widely expected to lay the foundation for coating humanoids such as South Korea"s HUBO or Japan"s ASIMO with artificial skin.
HUBO is a humanoid robot recently developed by KAIST. It is capable of moving its fingers independently, dancing and shaking hands with people by using its 41 joints.
Japan"s ASIMO, an acronym for Advanced Step in Innovative Mobility, was unveiled in 2000 as the world"s most advanced bi-pedal robot.
Through several upgrades, it is now able to spin in the air, bend or twist its torso and maneuver around obstacles in its path.
2005.02.02 View 13885