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The Journal of Clinical Investigation: Researchers Uncover the Secret Lymphatic Identity of the Schlemm's Canal
The Journal of Clinical Investigation (JCI), a peer-reviewed, top-tier medical journal published by the American Society for Clinical Investigation, carried a commentary entitled “Schlemm’s Canal: More Than Meets the Eye, Lymphatics in Disguise” in the July 25, 2014 issue.
In the commentary, the authors compared a research paper (“Lymphatic regular PROX1 determines Schlemm’s canal integrity and identity”) by Professor Gou-Young Koh of the Graduate School of Medical Science and Engineering at KAIST with research work from the University of Helsinki (article entitled “The Schlemm’s canal is a VEGF-C/VEGFR-3 responsive lymphatic-like vessel”).
The JCI released a press statement dated July 25, 2014 on its commentary. It mentioned that glaucoma, one of the leading causes of blindness worldwide, elevates eye pressure owing to poor drainage of aqueous humor. A specialized structure called “Schlemm’s canal” funnels aqueous humor from the eye back into circulation, which is critical to prevent pressure buildup in the eye. The article discussed the role of Schlemm’s canal in the context of lymphatic vascular characteristics by reviewing two research group’s papers back-to-back.
For the full text of the press release, please visit the link below:
Press Release from the Journal of Clinical Investigation, July 25, 2014
“Researchers uncover the secret lymphatic identity of the Schlemm’s canal”
http://www.eurekalert.org/pub_releases/2014-07/joci-rut072414.php
2014.07.28 View 8561 -
Interview with KAIST MBA: 5 Reasons to Study in Korea for Your MBA
The Graduate Management Admission Council (GMAC) published online an interview with Mija Yoon, the director of the Admission & Placement Center at KAIST College of Business (KAIST MBA) in Seoul, Korea, on July 18, 2014.
In the interview, Director Yoon listed the benefits of studying MBA programs at Korean universities, as well as working in Korea.
For the article, please visit the link below:
GMAT, July 18, 2014
“5 Reasons to Study in Korea for Your MBA”
http://www.beatthegmat.com/mba/2014/07/18/5-reasons-to-study-in-korea-for-your-mba
2014.07.21 View 9458 -
Professor Kyu-Young Whang Receives Contributions Award from ACM SIGMOD
Kyu-Young Whang, Distinguished Professor of Computer Science at KAIST, was the recipient of the 2014 ACM SIGMOND Contributions Award.
Founded in 1947, the Association for Computing Machinery (ACM) is the world’s largest educational and scientific computing society, delivering resources that advance computing as a science and profession.
SIGMOD is the Association for Computing Machinery’s Special Interest Group on Management of Data, which specializes in large-scale data management problems and databases.
Since 1992, ACM SIGMOND has presented the contributions award to one scientist who has made significant contributions to the field of database systems through research funding, education, and professional services. So far, 23 people including Professor Whang have received the award.
Professor Whang was recognized for his key role in the growth of international conferences and journals in the field of databases such as The VLDB Journal (The International Journal on Very Large Data Bases), VLDB Endowment Inc., IEEE Technical Committee on Data Engineering, and Database Systems for Advanced Applications (DASFAA). IEEE stands for the Institute of Electrical and Electronics Engineering.
For the full list of ACM SIGMOND Contributions Award recipients, please go to
http://www.sigmod.org/sigmod-awards/sigmod-awards#contributions.
2014.07.15 View 9288 -
Opening of "Education Donation Center" for Knowledge Sharing
KAIST is a leader in knowledge-sharing services for the educationally underprivileged. KAIST held the opening ceremony of the Education Donation Center at its Munji Campus on July 4, 2014 and was appointed as a “2014 Chungcheong-Gangwon province model local education donation center” sponsored by the Education Ministry of Korea and Korea Foundation for the Advancement of Science and Creativity.
The Education Donation Center (EDC) will integrate programs run by the Chungcheong-Gangwon province education donation organizations and introduce them to local chapter organizations. The EDC will recommend new donation organizations to the organizations in need. To ensure efficient donation, the EDC will consult programs of donation organizations. The EDC will also suggest regionally suitable education donation programs. KAIST will provide three staff members, six graduate students, and one to manage the career counselor to the center.
Joo-Sung Lee of the Business & Technology Management Department is the professor in charge of the EDC. He explained, “The center is the medium between the newly participating education donation organizations and the demand organizations. I will invest every effort to provide high-quality educational benefits to educationally underprivileged people."
KAIST has also been running an education service group called ‘Midam Scholarship’, an online education donation group called ‘Chalk’, and science camp programs for youth to establish the sharing and collaboration culture of KAIST.
2014.07.10 View 9357 -
The ICISTS-KAIST International Conference from August 4-8, 2014 in KAIST Campus, Korea
"Does science lead progress?"
This thought-provoking question will be explored this summer with hundreds of university students gathered from all around the world at the campus of the Korea Advanced Institute of Science and Technology (KAIST), a leading science and technology university in Korea.
Established in 2005, the International Conference for Integration of Science, Technology and Society (ICISTS)-KAIST has been hosted every summer for Korean and international university students in Daejeon, Republic of Korea. The conference features distinguished speakers from academia, business, and public sectors and enables participants to exchange views, identify issues affecting science and society, and explore possible solutions.
The ICISTS-KAIST is the largest interdisciplinary conference in Asia. It is organized by undergraduate students of KAIST and promotes the idea of a science- and technology-integrated society through international cooperation of college students from diverse backgrounds. Last year alone, about 400 participants from 103 universities in 25 countries attended the conference.
Marking the 10th anniversary, the ICISTS-KAIST International Conference 2014 will scrutinize the fundamental aspect of scientific and technological progress versus social advancement under the theme of "Does Science Lead Progress?"
"We hope that the conference provides students with an interactive platform to look into some of the essential, yet easily neglected, questions such as the purpose of science and technology education in a broader context of social values," said Dong-Yeon Woo, President of Organizing Committee for the ICISTS-KAIST International Conference 2014.
Among keynote speakers are Langdon Winner, a professor of Science and Technology Studies at Rensselaer Polytechnic Institute, Stephen Hilgartner, an associate professor of Science and Technology Studies at Cornell University, and Steve Breyman, an associate professor of Science and Technology Studies at Rensselaer Polytechnic Institute.
Langdon Winner will speak about the fallacy of the public perception that technological innovation leads to social revolution (his presentation is entitled "The Myth of Innovation"). Stephen Hilgartner will present four aspects of the politics of vision in today's science and technology ("Science, Technology, and the Politics of Vision"), and Steve Breyman will talk about the origin of scientific deception, misrepresentation, and prevarication ("The Agnotology of Hydrofracking").
The conference lasts five days, beginning on August 4th through August 8th, 2014 at KAIST campus. For participation, regular online application opens until July 11, 2014 at http://www.icists.org.
2014.07.04 View 9958 -
Forbes Asia: 48 Heroes of Philanthropy
Mun-Sul Jeong
Hui-Jeong Park
Forbes Asia, an American business magazine covering the latest news on Asian markets, politics, business, and finance, announced the list of 48 philanthropists in the Asia-Pacific region in its July 21, 2014 issue.
Four Koreans made the list: Mun-Sul Jeong (a former chairman of KAIST's Board of Trustees), Hui-Jeong Park (a wife of the late Dr. Geun-Chul Ryu, a philanthropist who gave the funds to build the Sports Complex in KAIST campus), Yuna Kim (a former Olympics figure skater and a gold and silver medalist), and Nam-Kyu Min (the chairman of JK Group, a plastics and petrochemical products manufacturer).
Mun-Sul Jeong, the founder of Mirae Corp., a semiconductor equipment manufacturing company, donated $21 million to KAIST for brain science research this year. He also donated $235 million to KAIST in 2001 for convergence research in information and business technology.
Hui-Jeong Park, a former professor of nursing at Korea University, endowed a $100,000 scholarship fund for KAIST students in January 2014. Her late husband, Dr. Geun-Chul Ryu, contributed over $55 million in real estate to KAIST, allowing the university to have a new sports facility. He was an eminent doctor of Oriental medicine in Korea and also served as a professor at KAIST.
For more, please click on the link below:
Forbes Asia, July 21, 2014
“48 Heroes of Philanthropy”
http://www.forbes.com/sites/johnkoppisch/2014/06/25/48-heroes-of-philanthropy-3/
2014.06.26 View 9587 -
The First Demonstration of a Self-powered Cardiac Pacemaker
As the number of pacemakers implanted each year reaches into the millions worldwide, improving the lifespan of pacemaker batteries has been of great concern for developers and manufacturers. Currently, pacemaker batteries last seven years on average, requiring frequent replacements, which may pose patients to a potential risk involved in medical procedures.
A research team from the Korea Advanced Institute of Science and Technology (KAIST), headed by Professor Keon Jae Lee of the Department of Materials Science and Engineering at KAIST and Professor Boyoung Joung, M.D. of the Division of Cardiology at Severance Hospital of Yonsei University, has developed a self-powered artificial cardiac pacemaker that is operated semi-permanently by a flexible piezoelectric nanogenerator.
The artificial cardiac pacemaker is widely acknowledged as medical equipment that is integrated into the human body to regulate the heartbeats through electrical stimulation to contract the cardiac muscles of people who suffer from arrhythmia. However, repeated surgeries to replace pacemaker batteries have exposed elderly patients to health risks such as infections or severe bleeding during operations.
The team’s newly designed flexible piezoelectric nanogenerator directly stimulated a living rat’s heart using electrical energy converted from the small body movements of the rat. This technology could facilitate the use of self-powered flexible energy harvesters, not only prolonging the lifetime of cardiac pacemakers but also realizing real-time heart monitoring.
The research team fabricated high-performance flexible nanogenerators utilizing a bulk single-crystal PMN-PT thin film (iBULe Photonics). The harvested energy reached up to 8.2 V and 0.22 mA by bending and pushing motions, which were high enough values to directly stimulate the rat’s heart.
Professor Keon Jae Lee said:
“For clinical purposes, the current achievement will benefit the development of self-powered cardiac pacemakers as well as prevent heart attacks via the real-time diagnosis of heart arrhythmia. In addition, the flexible piezoelectric nanogenerator could also be utilized as an electrical source for various implantable medical devices.”
This research result was described in the April online issue of Advanced Materials (“Self-Powered Cardiac Pacemaker Enabled by Flexible Single Crystalline PMN-PT Piezoelectric Energy Harvester”: http://onlinelibrary.wiley.com/doi/10.1002/adma.201400562/abstract).
Youtube link: http://www.youtube.com/watch?v=ZWYT2cU_Mog&feature=youtu.be
Picture Caption: A self-powered cardiac pacemaker is enabled by a flexible piezoelectric energy harvester.
2014.06.25 View 16955 -
KAIST studnets win 2014 Creative Vitamin Project Competition
A team of KAIST students have won the grand prize for the “2014 Creative Vitamin Project Competition” held on May 28, 2014 in Seoul. The event was co-hosted by the Ministry of Science, ICT and Future Planning, National Information Society Agency, and Korea IT Convergence Technology Association. The Creative Vitamin Project is the Korean government’s initiative to grow the Korean economy and generate job creation by applying science and technology, information and communications technology in particular, to the existing industry and social issues.
The winners were Hyeong-Min Son, a student in the master’s program in the Department of Civil and Environmental Engineering, KAIST and Su-Yeon Yoo, a Ph.D. student from the Graduate School of Information Security, KAIST.
Son and Yoo proposed a sustainable crop protection system using directional speakers. This technique not only efficiently protects crops from harmful animals, but also effectively guides the animals outside the farmland.
Kwang-Soo Jang, the Director of the National Information Society Agency, said, “This competition provides an opportunity to develop public consensus and interest in the Creative Vitamin Project. We hope that through the participation of all citizens, the project can become an instrument to realizing the creative economy.”
2014.06.18 View 11121 -
A mechanism for how reactive oxygen species cause cell responses studied
A research team led by Professor Kwang-Hyun Cho of the Department of Biology and Brain Engineering, KAIST, and Dr. Gi-Sun Kwon of the Korea Research Institute of Bioscience and Biotechnology succeeded in proving the mechanism behind the determination of cell life in relation to reactive oxygen species.
The results of the venture were published in the June 3rd edition of Science Signaling. The title of the research paper is “MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.”
The research team discovered that the molecular switch that determines the division of apoptosis of a cell was based on MLK3 feedback mechanism. MLK stands for mixed-lineage kinase.
Under sufficient stress, the mechanism instructs the cell to undergo the division but in an overly stressful environment, the mechanism stops the cell division and instead, induces apoptosis. This discovery is expected to be a breakthrough in illnesses related to the concentration of the reactive oxygen species (ROS).
At low concentration of ROS, the protein associated with cell division, ERK (extracellular-signal-regulated kinase), is activated while as the ROS concentration increases, JNK (c-Jun N-terminal protein kinases), responsible for apoptosis, becomes activated. Furthermore, through computer simulation analysis and mathematical modeling, in tandem with molecular cell biology experiments, the MLK3 based feedback mechanism was the fundamental molecular switch that determines the balance between ERK and JNK, and ultimately the cell’s responses.
Professor Cho commented that “the contradicting cell responses to ROS had remained a mystery, but with the system biology, an approach in which information technology and biotechnology converge, such riddles can be resolved. We expect that the proven mechanism will be used to overcome aging or cancer growth as a result of ROS in the near future.”
Picture shows the process of identifying cell responses caused by reactive oxygen species.
2014.06.13 View 9686 -
Professor YongKeun Park Produces Undergraduate Students with International Achievements
Three undergraduate students under the supervision of Professor YongKeun Park from the Department of Physics, KAIST, have published papers in globally renowned academic journals.
The most recent publication was made by YoungJu Jo, a senior in physics. Jo’s paper entitled “Angle-resolved light scattering of individual rod-shaped bacteria based on Fourier transform light scattering” was published in the May 28th edition of Scientific Reports.
Analyzing bacteria is a very important task in the field of health and food hygiene, but using the conventional biochemical methods of analysis takes days. However, observation with Jo’s newly developed method using light scattering analyzes bacteria within a matter of seconds.
SangYeon Cho from the Department of Chemistry also published papers in Cell (2012) and Nature (2013), respectively, under the guidance of Professor Park. SangYeon Cho’s outstanding research achievements were recognized by Harvard and MIT. He was accepted with a full scholarship to Harvard-MIT Health Sciences and Technology Graduate School. He will begin his graduate studies at Harvard-MIT this September.
Last March, SeoEun Lee from the Department of Biology was the recipient of the Best Paper Award by the Optical Society of Korea. She plans to pursue a doctoral degree at the College of Physicians and Surgeons, Columbia University in New York.
Professor Park said, “Undergraduate students, who are learning a variety of subjects concurrently, are at the most creative time of their lives. KAIST has offered many opportunities to undergraduate students to partake in various research programs.”
- Picture (a) and (b): Rod-shaped bacteria’s phase image and light-scattering patterns
- Picture (c): Quantitative analysis to illustrate the extraction of information from bacteria
2014.06.03 View 13283 -
Professor Kyu-Young Whang receives the PAKDD Distinguished Contributions Award
Professor Kyu-Young Whag
Dr. Kyu-Young Whang, Distinguished Professor from the Department of Computer Science, KAIST, has received the 2014 Distinguished Contributions Award from the Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD). PAKDD is the leading academic international conference on data mining held in Asia/Pacific. This year’s international conference was held from 13th to 15th May at Tainan, Taiwan.
As a life member of the PAKDD Steering Committee, Professor Whang worked for the development of the data mining field in the Asia-Pacific region, and his contribution to the international database and data-mining field has been widely recognized.
The PAKDD Distinguished Contributions Award has been awarded to a total of six people until now, including Professor Whang, and he is the first Korean to receive this award.
Professor Whang has also a history of receiving the Outstanding Contributions Award in 2011 from the Database Systems for Advanced Applications (DASFAA), the prestigious database academic conference in the Asia-Pacific region. The database and data mining field in the region was barren 20 years ago, but through the efforts and contributions of many researchers, including Professor Whang, it has now leapt to the level of being the equal of North American and European researchers.
In fact, three academic organizations in the current international database field are led by professors in the Asia-Pacific region. The IEEE ICDE (Institute of Electrical and Electronics Engineers Technical Committee on Data Engineering) is led by Professor Whang; the VLDB (Very Large Data Base) Endowment by Professor Beng Chin Ooi from National University of Singapore (NUS); and the ACM SIGMOD (Association for Computing Machinery Special Interest Group on Management of Data) by Professor Don Kossmann from ETH Zurich.
2014.05.26 View 9064 -
KAIST Made Great Improvements of Nanogenerator Power Efficiency
The energy efficiency of a piezoelectric nanogenerator developed by KAIST has increased by almost 40 times, one step closer toward the commercialization of flexible energy harvesters that can supply power infinitely to wearable, implantable electronic devices.
NANOGENERATORS are innovative self-powered energy harvesters that convert kinetic energy created from vibrational and mechanical sources into electrical power, removing the need of external circuits or batteries for electronic devices. This innovation is vital in realizing sustainable energy generation in isolated, inaccessible, or indoor environments and even in the human body.
Nanogenerators, a flexible and lightweight energy harvester on a plastic substrate, can scavenge energy from the extremely tiny movements of natural resources and human body such as wind, water flow, heartbeats, and diaphragm and respiration activities to generate electrical signals. The generators are not only self-powered, flexible devices but also can provide permanent power sources to implantable biomedical devices, including cardiac pacemakers and deep brain stimulators.
However, poor energy efficiency and a complex fabrication process have posed challenges to the commercialization of nanogenerators. Keon Jae Lee, Associate Professor of Materials Science and Engineering at KAIST, and his colleagues have recently proposed a solution by developing a robust technique to transfer a high-quality piezoelectric thin film from bulk sapphire substrates to plastic substrates using laser lift-off (LLO).
Applying the inorganic-based laser lift-off (LLO) process, the research team produced a large-area PZT thin film nanogenerators on flexible substrates (2cm x 2cm).
“We were able to convert a high-output performance of ~250 V from the slight mechanical deformation of a single thin plastic substrate. Such output power is just enough to turn on 100 LED lights,” Keon Jae Lee explained.
The self-powered nanogenerators can also work with finger and foot motions. For example, under the irregular and slight bending motions of a human finger, the measured current signals had a high electric power of ~8.7 μA. In addition, the piezoelectric nanogenerator has world-record power conversion efficiency, almost 40 times higher than previously reported similar research results, solving the drawbacks related to the fabrication complexity and low energy efficiency.
Lee further commented,
“Building on this concept, it is highly expected that tiny mechanical motions, including human body movements of muscle contraction and relaxation, can be readily converted into electrical energy and, furthermore, acted as eternal power sources.”
The research team is currently studying a method to build three-dimensional stacking of flexible piezoelectric thin films to enhance output power, as well as conducting a clinical experiment with a flexible nanogenerator.
This research result, entitled “Highly-efficient, Flexible Piezoelectric PZT Thin Film Nanogenerator on Plastic Substrates,” was published as the cover article of the April issue of Advanced Materials. (http://onlinelibrary.wiley.com/doi/10.1002/adma.201305659/abstract)
YouTube Link: http://www.youtube.com/watch?v=G_Fny7Xb9ig
Over 100 LEDs operated by self-powered flexible piezoelectric thin film nanogenerator
Flexible PZT thin film nanogenerator using inorganic-based laser lift-off process
Photograph of large-area PZT thin film nanogenerator (3.5cm × 3.5cm) on a curved glass tube and 105 commercial LEDs operated by self-powered flexible piezoelectric energy harvester
2014.05.19 View 14793