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KAIST Celebrates 50-Year Anniversary with 2,712 New Graduates via 2021 Commencement Ceremony
KAIST is proud to announce the graduation of 2,712 students, including 668 PhDs and 1,331 master’s degree recipients. The pandemic could not stop the university from recognizing each graduate's remarkable and original achievements. A pandemic-proof blended commencement ceremony was held on Friday, February 19, and livestreamed to the graduates and their loved ones.
KAIST decided to take extra precautions to protect graduates and other attendees’ health and well-being.
For the virtual ceremony, only 83 out of the 2,712 graduates were invited to attend the ceremony in person. Graduates were divided into four groups to attend at four different places in Daejeon and Seoul campuses and watch the ceremony via Zoom. No family members or friends of the graduates were allowed to participate at the campus, but happily cheered the graduates via YouTube.
This year’s valedictorian, Hyun-Young Park from the School of Electrical Engineering, received the Award of the Minister of Science and ICT. Salutorian Yeh-Lin Cho from the Department of Materials Science and Engineering received the Award of the KAIST Board of Trustees, while the recipient of the KAIST Presidential Award was Min-Jae Kim from the Department of Bio and Brain Engineering. The Award of the KAIST Development Foundation Chairman and the KAIST Alumni Association Presidential Award were conferred to Kyung-Tae Kim from the Department of Physics and Min-Woo Jung from the Department of Civil and Environmental Engineering, respectively.
President Sung-Chul Shin, Chairman of the Board of Trustees Woo Sik Kim, and a very limited number of faculty members and administrative staff officiated the commencement ceremony from the KAIST Auditorium.
President Shin applauded the graduates’ hard work and dedication in his commencement speech. He also delivered a very special congratulatory message to the bachelor’s degree awardees.
“This year’s commencement is especially meaningful for me. I was appointed as the 16th president of KAIST on February 23, 2017, and met you for the first time on February 28 at the matriculation ceremony. We promised each other—as freshmen and as the first alumnus president—to do our best for the next four years,” President Shin recalled.
He added, “I have done my best to keep my promise, and now my term will end on February 22. Of course, the past four years were even more precious because you were all a part of it.”
In conclusion, President Shin said, “I am proud of you for keeping your end of the promise. Thank you for becoming who you are today. I have high hopes for the bright future that you will be shaping for KAIST and our society.”
The livestream ceremony is archived for viewing on KAIST's Official YouTube Channel.
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2021.02.19 View 7491 -
Provost Kwang Hyung Lee Elected as the 17th President of KAIST
Provost and Executive Vice President Kwang Hyung Lee was selected as the 17th president of KAIST during a vote of the KAIST Board of Trustees on February 18. He will succeed President Sung-Chul Shin, whose four-year term concludes on February 22.
President-elect Lee, 67, was among the three final candidates who were nominated by the Presidential Search Committee. Upon the selection, President-elect Lee said he will take up new challenges to transform KAIST into the most relevant research university in the world, fostering talents who can work with emerging technologies while pushing for innovative R&D initiatives that will benefit all of humanity.
President-elect Lee is a futurologist who pioneered multidisciplinary studies and research at KAIST. He advocated that the convergence of information, biology, and nano-technologies would be critical for future industries, playing a crucial role in establishing the Department of Bio and Brain Engineering in 2001 and the Moon Soul Graduate School of Future Strategy in 2013. He then served as the inaugural head of both faculties.
President-elect Lee has extensive administrative experience at KAIST, serving as Associate Vice President of the International Office, and Associate Vice President of Academic Affairs since early 2001. He is also serving as a member of the Korea Presidential Education Committee.
An ardent champion of entrepreneurship and startups, he has advised the first generations of KAIST startup entrepreneurs such as Nexon, Idis, Neowiz, and Olaworks. President-elect Lee, drawn to creative thinking and flipped learning, is famous for watching TV upside down. Such pioneering ideas and his unusual thinking style were modeled in the ‘eccentric professor’ role featured on the TV hit drama of ‘KAIST’ from 1999 to 2000.
An alumnus who earned his MS in industrial engineering at KAIST in 1980 after completing his undergraduate studies at Seoul National University, President-elect Lee joined the KAIST faculty in 1985 upon receiving his PhD in computer science from INSA de Lyon in France.
A computer scientist as well as fuzzy theorist whose research area extends to AI, bioinformatics, fuzzy intelligent systems, and foresight methods, Professor Lee has published more than 70 papers in international journals and textbooks on system programming, fuzzy set theory and its applications, and three-dimensional creativity. He also invented a fuzzy elevator, subway operation controller, and AI transportation controller.
A fellow at the Korea Academy of Science and Technology and the National Academy of Engineering of Korea, he was decorated by the Korean government and the French government in recognition of the innovative education and research initiatives he has pursued.
2021.02.18 View 8638 -
KAIST International Symposium Highlights the Value of Science through Global Collaboration
The presidents of three premier science and technology universities shared their belief that universities should move forward to embrace social changes while maintaining the importance of academics for future generations during the KAIST International Symposium on February 16.
The symposium, one of the events to celebrate KAIST’s 50th anniversary, highlighted the future role of universities over the next 50 years by hosting a panel featuring ETH Zurich President Joël Mesot, Caltech President Thomas Rosenbaum, and KAIST President Sung-Chul Shin. Members of the foreign diplomatic corps representing seven countries also explored the new model of global collaboration in the second session.
President Rosenbaum of Caltech said that even though society is changing, the role of universities will not be different since the value of knowledge will always be important. He said that universities must embrace change.
He said that universities should move forward fearlessly if they believe it would impact wider society positively. He added that universities should also be courageous enough to take a new path based on longer-term perspectives and lessons learned from successes. One of the roles of universities is to establish various hypotheses and possible prospects, raise doubts, and go forward with a strong will for the future generations to come.
He cited LIGO (the Laser Inerferometer Gravitational-wave Observatory), as a good example of a successful university-research collaboration. LIGO is funded by the National Science Foundation in the US and operated by Caltech and MIT. Approximately 1300 scientists from around the world, including the Max Planck Society in Germany and the Science and Technology Facilities Council in the UK, participate in the LIGO Scientific Collaboration. In 2019, the international team of scientists detected the collision of two black holes with masses about 142 times the mass of the sun in the most massive collision ever detected. MIT Physicist Rainer Weiss shared the Nobel Prize in Physics with Professor Barry Barish and Professor Kip Thorn from the Department of Physics at Caltech in recognition of their contribution to the LIGO detector and the observation of gravitational waves.
President Mesot of ETH Zurich stressed that universities should foster young talents well versed with creative thinking and entrepreneurship in this new era. He also said that COVID-19 has reaffirmed the importance of science and global collaborations beyond borders to address global challenges such as pandemics. President Mesot said COVID-19 has taught us the value of science and R&D, adding that the roll-out of a vaccine in only one year would have been impossible without the decades-long R&D foundation that universities and industries have established.
He also gave the example of the MRI as a reason universities should provide strong basic science research foundation. In 1944 in the US, Dr. Isidor Isaac Rabi won the Nobel Prize in Physics for his discovery of nuclear magnetic resonance. The MRI research inspired many ETH professors for further studies and led them to win the Nobel Prize in Physics in 1952 for their MRI basic theory and in 1991 the Nobel Prize in Chemistry with the development of high-resolution spectroscopy. “The MRI first started 80 years ago and still applies in today’s medicine. We should focus on research which will keep such value,” President Mesot said.
Meanwhile President Shin also said that the age of the Fourth Industrial Revolution has been deemed the "winner takes all" era. At this highly competitive time, R&D activities are more meaningful if they produce the world’s best, first, and only outcomes.
“We aim to achieve excellence in research with long-term innovative research support systems. We will conduct R&D activities that will lead the megatrends of the Fourth Industrial Revolution: hyper-connectivity, super-intelligence, and meta-convergence. In addition, we will double down to conduct forward-looking flagship research that will enhance the happiness and prosperity of all humanity in the areas of global warming, infectious diseases, bio-medicine, energy and environment, smart technology, and post-AI.”
Responding to one of the student’s question about what mindsets are expected of students enrolled in government-funded national universities, President Mesot made three suggestions. First, they should remember that they are privileged, so they should give back their talents to society. They should also be patient with what they are doing even when they don’t achieve the desired results. Lastly, they should remain open to new ideas and be flexible when encountering disruptions.
Seven diplomats stationing in Korea including Rob Rapson, US Charge d’Affairs ad Interim Rob Rapson, UAE Ambassador Abdulla Saif Al Nuaimi, Kenyan Ambassador Mwende Mwinzi, Danish Ambassador Einar Jensen, Pakistani Ambassador Mumtaz Zahar Baloch, Egyptian Ambassador Haem Fahmy, and UK Ambassador Simon Smith joined the second session themed KAIST for the Global Community.
They all agreed that KAIST is one of the shining examples of successful international collaboration stemming from the international aid loan from USAID. Five decades later, KAIST now is working to help the Kenyan government to establish Kenya KAIST with a 95-million US funding from the Korea Exim Bank.
While stressing the importance of global collaboration for inclusive growth in the global community, the seven diplomats gave their insights on the newly transforming global environment intertwined with COVID-19 and the Fourth Industrial Revolution.
In the face of global changes caused by emerging technologies and carbon neutrality, the ambassadors expressed a strong desire to make collaborations between KAIST and their countries to propel new innovations in industry and education in their countries.
2021.02.17 View 7765 -
Ushering in a New Era at the 50th Innoversary Ceremony
President Moon Jae-In declares KAIST the future of Korea
KAIST reaffirmed its goal of becoming an institute that can serve the world for the next century, marking its 50th anniversary on February 16. The KAIST community and distinguished guests gathered online during the official ceremony to commemorate KAIST’s anniversary and envisioned ways to serve the world, a major shift from its founding mission focusing on national growth.
The ceremony celebrated the legacy of KAIST, which has become a trailblazer by fostering the most competent scientists and engineers and making breakthroughs which led to the nation becoming a global high-tech leader.
President Moon Jae-In applauded KAIST as “the future of Korea” in his online congratulatory message, saying that “KAIST has made us feel proud when the nation stays ahead in science and technology. The dream of KAIST has been the dream of Korea. The passion of KAIST has been the passion of Korea. KAIST is the future of Korea.”
“KAIST has overcome challenges and created innovations for advancing the nation, from the first internet network to launching our first satellite in the early 80s to the Mobile Clinic Module (MCM), a negative pressure ward module in response to COVID-19. Whenever the nation faced a challenge, KAIST was there.”
President Moon also asked KAIST researchers to find sustainable ways to balance nature and humanity in this time of climate change and the Fourth Industrial Revolution.
Executive Chairman of the World Economic Forum Dr.Klaus Schwab also congratulated, saying "KAIST is a leader in ensuring social inclusion. Founded with the support of USAID, today it is paying it forward and sharing the same support through the Kenya-KAIST project."
The ceremony first brought Dr. KunMo Chung to the stage, the man who proposed the idea of founding the first advanced science and technology institute in Korea. His proposal to the then administrator of USAID John Hannah resulted in the Korean government meriting a 6 million USD loan for to start KAIST. He was the only Korean member of the USAID feasibility study team led by Dr. Frederick Terman, the former vice president of Stanford University. Dr. Chung wrote the Terman Report, which gave a green light to the establishment of KAIST in Korea in 1970.
Dr. Chung said the nation’s strong desire to escape from poverty through the advancement of science and technology was thoroughly realized by KAIST. “The Terman Report’s vision was perfectly realized. Now it’s time to envision the next dream of KAIST for another century.”
President Sung-Chul Shin said in his anniversary speech that KAIST has now transformed into a university that will serve the all of humanity by advancing science and technology while fostering new talents best fit for the new global environment. President Shin said that to fulfill KAIST’s second dream, the university will drive innovation in the five major areas of education, research, technology commercialization, globalization, and future strategy, under the C3 spirit of a Challenging spirit, Creativity, and Caring minds.
“In the next 50 years, KAIST hopes to fulfill the 10-10-10 Dream, that is, to have 10 Singularity Professors who have produced world-class achievements, 10 Decacorn startups valued at 10 trillion won, and global campuses in 10 countries.”
Then, four young KAIST professors who are conducting research in the flagship fields of mobility, new materials, post-AI, and bio-medicine presented their research vision and gave speeches. Professor Hae-Won Park from the Department of Mechanical Engineering and Professor Jihyeon Yeom from the Department of Materials Science and Engineering said the advent of new mobility combined with robotics and new nano-materials scaled down into spintronics, ‘KAISTronic materials’, will provide new momentum for the industry and the wellbeing of humanity. Professor Kijung Shin from the Graduate School of AI spoke on the new future transformed by quantum computers. Professor Young Seok Ju from the Graduate School of Medical Science and Engineering predicted a future in which cancer will no longer be a terminal disease and digital cells and the digitization of bio-medicine will significantly improve our quality of life. He said the combination of anti-aging and reverse aging studies will make a difference in our lives.
After the official ceremony, KAIST’s administrative leadership including President Shin and Dr. Kun-Mo Chung attended a ceremony to dedicate the sky lounge at the Academic Cultural Complex as the John Hannah Hall. Terman Hall, located in the Creative Learning Building, was dedicated in 2004 in honor of Dr. Frederick Terman.
2021.02.17 View 11134 -
Distinguished Alumni Awardees 2020
The KAIST Alumni Association (KAA) announced the four recipients of the Distinguished Alumni Awards for the year 2020.
The Distinguished Alumni Awards recognize graduates who have achieved outstanding accomplishments in their professional and personal lives, and who have been an inspiration to fellow alumni and students in Korea and around the globe. The four distinguished alumni of the year 2020 are listed below.
President Dong-Won Kim (Department of Industrial and Systems Engineering, M.S., Class of ’82) of Jeonbuk National University is making significant contributions to the advancement of local industrial technology and the cultivation of professional personnel through outstanding research outcomes. As an educational administrator, his leadership is helping to realize long-desired projects at the university, through which he is strengthening the competitiveness of the university and the local community.
Tae-Kyung Yoo (School of Electrical Engineering, M.S. and Ph.D., Class of ’83 and ’85 respectively), CEO and Chairman of Lumens, is a first-generation entrepreneur in the light emitting diode (LED) industry in Korea. He runs Lumens, a globally renowned company specializing in and leading the technological innovation of LEDs. He thereby contributes to strengthening national competitiveness and the advancement of science and technology.
President Nak Kyu Lee (Department of Mechanical Engineering, M.S. and Ph.D., Class of ’85 and ’87 respectively) of the Korea Institute of Industrial Technology (KITECH) has shown excellent results in his research in which he developed core production technologies to lead the nation’s industries. He also focused on supporting on-site technologies involved in field work to apply what he developed into real production processes, and contributed greatly to improving the competitiveness of nationwide manufacturing.
Hyeon-Mo Ku (School of Business and Technology Management, M.S. and Ph.D., Class of ’85 and ’93 respectively), CEO of KT Corporation, helped the nation’s leading communications company roll out the first 5G network in the world. He also strengthened national competitiveness in AI technology through ‘AI One Team,’ an industry-academic corporation project, and took the lead in developing the home-grown cloud industry. His involvement in the innovation of Korea’s ICT technology was highly recognized.
Since the establishment of the award in 1992, a total of 107 alumni at home and abroad have brought distinction to the university and been honored as recipients.
These recipients are playing major roles in society, and some of the notable former awardees include: KAIST President Sung-Chul Shin (2010), Samsung Electronics Vice Chairman Ki-Nam Kim (2012), Nexon Chairman Jung-Ju Kim (2007), and Krafton Chairman Byeong-Gyu Chang (2006).
The President of the KAA and Advisor of Samsung Electronics, Chilhee Chung, said, “The Distinguished Alumni Awards are an honor given to alumni who have contributed to the development of the nation and society, and raised the name of their alma mater.” He added, “We can see the proud position of KAIST in the global arena just by looking at the accomplishments of our awardees.”
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2021.02.04 View 7091 -
COVID-Update: Spring 2021 Classes Continue Online
KAIST announced that its spring 2021 classes will also be online as the pandemic continues into the new year. The spring semester will begin on March 1.
Executive Vice President and Provost Kwang Hyung Lee said in a letter to the KAIST community on January 15 that nearly all classes in the 2021 spring semester will be held online. However, a very limited number of lab classes and other classes that require on-site practice and demonstrations will be offered either in-person or in a blended format. In addition, graduate courses above the 600 level and graduate courses in the College of Business at the Seoul campus will be allowed to conduct in-person or blended classes under very strict social distancing guidelines.
Provost Lee said that the university will be revert back to in-person classes as soon as the government eases the social distancing guidelines. As of February 4, the nation is under Level 2.5 in Seoul and its metropolitan areas, while other regions are at Level 2. Level 2.5 prohibits the gathering of 10 or more people, and Levels 1 and 2 require gatherings to be fewer than 50 people. At Level 3, all classes will be held online.
Test management is another challenge. Regarding mid-term and final exams, the university plans to give more flexibility to professors. Professors may give additional assignments instead of a mid-term exam. Open-book exams and real-time exams through Zoom will be another option. However, some classes that require in-person tests in some graduate courses will be allowed as long as they follow very strict social distancing guidelines.
2021.02.04 View 4597 -
Highly Deformable Piezoelectric Nanotruss for Tactile Electronics
With the importance of non-contact environments growing due to COVID-19, tactile electronic devices using haptic technology are gaining traction as new mediums of communication.
Haptic technology is being applied in a wide array of fields such as robotics or interactive displays. haptic gloves are being used for augmented information communication technology. Efficient piezoelectric materials that can convert various mechanical stimuli into electrical signals and vice versa are a prerequisite for advancing high-performing haptic technology.
A research team led by Professor Seungbum Hong confirmed the potential of tactile devices by developing ceramic piezoelectric materials that are three times more deformable. For the fabrication of highly deformable nanomaterials, the research team built a zinc oxide hollow nanostructure using proximity field nanopatterning and atomic layered deposition. The piezoelectric coefficient was measured to be approximately 9.2 pm/V and the nanopillar compression test showed an elastic strain limit of approximately 10%, which is more than three times greater than that of the bulk zinc oxide one.
Piezoelectric ceramics have a high piezoelectric coefficient with a low elastic strain limit, whereas the opposite is true for piezoelectric polymers. Therefore, it has been very challenging to obtain good performance in both high piezoelectric coefficients as well as high elastic strain limits. To break the elastic limit of piezoelectric ceramics, the research team introduced a 3D truss-like hollow nanostructure with nanometer-scale thin walls.
According to the Griffith criterion, the fracture strength of a material is inversely proportional to the square root of the preexisting flaw size. However, a large flaw is less likely to occur in a small structure, which, in turn, enhances the strength of the material. Therefore, implementing the form of a 3D truss-like hollow nanostructure with nanometer-scale thin walls can extend the elastic limit of the material. Furthermore, a monolithic 3D structure can withstand large strains in all directions while simultaneously preventing the loss from the bottleneck. Previously, the fracture property of piezoelectric ceramic materials was difficult to control, owing to the large variance in crack sizes. However, the research team structurally limited the crack sizes to manage the fracture properties.
Professor Hong’s results demonstrate the potential for the development of highly deformable ceramic piezoelectric materials by improving the elastic limit using a 3D hollow nanostructure. Since zinc oxide has a relatively low piezoelectric coefficient compared to other piezoelectric ceramic materials, applying the proposed structure to such components promised better results in terms of the piezoelectric activity.
“With the advent of the non-contact era, the importance of emotional communication is increasing. Through the development of novel tactile interaction technologies, in addition to the current visual and auditory communication, mankind will enter a new era where they can communicate with anyone using all five senses regardless of location as if they are with them in person,” Professor Hong said.
“While additional research must be conducted to realize the application of the proposed designs for haptic enhancement devices, this study holds high value in that it resolves one of the most challenging issues in the use of piezoelectric ceramics, specifically opening new possibilities for their application by overcoming their mechanical constraints.
The research was reported in Nano Energy and supported by the Ministry of Science and ICT, the Korea Research Foundation, and the KAIST Global Singularity Research Project.
-Profile: Professor Seungbum Hong
seungbum@kaist.ac.kr
http://mii.kaist.ac.kr/
Department of Materials Science and Engineering
KAIST
2021.02.02 View 9129 -
Top University Leaders Urge Innovation for the Post-COVID Era at the KAIST Summit
- Presidents of KAIST, MIT, Tokyo Tech, and Northwestern to define new roles and responsibilities of universities for the post-COVID and 4IR eras during an online summit in celebration of KAIST’s 50th anniversary. -
Universities are facing ever-mounting pressure to address impacts brought on by COVID-19 and the emerging technologies of the Fourth Industrial Revolution (4IR).
Presidents from MIT, Tokyo Tech, and Northwestern University will join the KAIST Summit to explore new directions for higher education during the post-COVID era intertwined with the 4IR. They agree that addressing these dual challenges requires pushing for innovations to rebuild the competitive edges of universities.
This summit is one of KAIST’s series of events to envision the future of KAIST and higher education in celebration of its 50th anniversary. The online summit will be live streamed on KAIST’s official YouTube channel (https://www.youtube.com/c/KAISTofficial) on February 3, 2021, from 10 a.m. to 12:00 p.m. Korean time (February 2, 7:00-9:00 p.m. CST and 8:00-10:00 p.m. EST, respectively).
The KAIST Summit titled “The Roles and Responsibilities of Universities in a Global Crisis” will discuss a range of issues affecting many aspects of universities in the coming decades.
“This summit will allow us to measure the level of risk that universities face today and will face in the future. Although there will be varying views on what a post-COVID world might look like, one thing for sure is that universities cannot go back to the way they used to exist and operate. Moreover, the 4IR continues to infiltrate and shake up our daily lives. Changes are inevitable, and universities must pursue bold and innovative responses to remain sustainable and relevant to society,” said KAIST President Sung-Chul Shin on the background of hosting the event.
The keynote speakers include KAIST President Shin, MIT President L. Rafael Reif, Tokyo Tech President Kazuya Masu, and Northwestern University President Morton Schapiro. After the keynote speech session, the speakers will take part in a panel discussion on three topics: “The Digital Divide,” “Emerging Challenges in AI,” and “Social Entrepreneurship and University-Industry Collaboration.” A Q&A session with an online audience consisting of KAIST faculty, staff, and students as well as high school students across the nation will follow shortly afterwards.
President Reif of MIT will congratulate KAIST on its successful 50-year journey from meager beginnings to achieving its current status as one of the finest global universities in science and technology. Then he will give a talk titled “Universities as Engines of Change” to present how universities have played a critical role in advancing solutions to humanity’s most urgent problems.
President Masu of Tokyo Tech will stress the importance of universities’ continuous dialogue with society as drivers of innovation. In his speech titled “Designing Our Future—Tokyo Tech DLab’s Approach,” he will introduce the activities of Tokyo Tech’s Laboratory for Design of Social Innovation in Global Networks (DLab) and explain how DLab collaborates for the future with members of society.
President Schapiro of Northwestern University will speak about how universities might incorporate the lessons they learned in dealing with COVID-19 to improve their research, teaching, and public service in the post-pandemic era. He will also look into issues arising from changing labor market needs associated with the 4IR and the aftermath of COVID-19 in his talk titled “The University in the ‘New Normal.’”
Finally, President Shin of KAIST will deliver a presentation on the “Visions & Innovations for the Next Dream of KAIST.” He will reflect on the remarkable track record from KAIST’s first 50 years and how it has contributed significantly to the rapid growth of Korea as a hi-tech powerhouse. Furthermore, he will elaborate on a new vision for the development of KAIST over the next 50 years and roll out a set of strategic innovation plans in the five areas of education, research, technology commercialization, globalization, and future strategy.
In the panel discussion, the four presidents will dive into a more intense conversation on such topics as universities’ role in bridging the increasing digital divide through their research, education, and international cooperation; the socioeconomic implications and ethical challenges of the fast deployment of AI and robotics; 4IR disruptions that will transform higher education; ways to foster social innovation and youth entrepreneurship; and how to build university-industry cooperation.
More information on KAIST’s 50th anniversary celebrations can be found on its special celebratory website at https://50.kaist.ac.kr/eng/. The official anniversary ceremony is scheduled for February 16, 2021, from 10 a.m. Korean time, and live-streaming will also be made available on KAIST’s official YouTube channel at https://www.youtube.com/c/KAISTofficial.
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2021.02.01 View 12565 -
Wirelessly Rechargeable Soft Brain Implant Controls Brain Cells
Researchers have invented a smartphone-controlled soft brain implant that can be recharged wirelessly from outside the body. It enables long-term neural circuit manipulation without the need for periodic disruptive surgeries to replace the battery of the implant. Scientists believe this technology can help uncover and treat psychiatric disorders and neurodegenerative diseases such as addiction, depression, and Parkinson’s.
A group of KAIST researchers and collaborators have engineered a tiny brain implant that can be wirelessly recharged from outside the body to control brain circuits for long periods of time without battery replacement. The device is constructed of ultra-soft and bio-compliant polymers to help provide long-term compatibility with tissue. Geared with micrometer-sized LEDs (equivalent to the size of a grain of salt) mounted on ultrathin probes (the thickness of a human hair), it can wirelessly manipulate target neurons in the deep brain using light.
This study, led by Professor Jae-Woong Jeong, is a step forward from the wireless head-mounted implant neural device he developed in 2019. That previous version could indefinitely deliver multiple drugs and light stimulation treatment wirelessly by using a smartphone. For more, Manipulating Brain Cells by Smartphone.
For the new upgraded version, the research team came up with a fully implantable, soft optoelectronic system that can be remotely and selectively controlled by a smartphone. This research was published on January 22, 2021 in Nature Communications.
The new wireless charging technology addresses the limitations of current brain implants. Wireless implantable device technologies have recently become popular as alternatives to conventional tethered implants, because they help minimize stress and inflammation in freely-moving animals during brain studies, which in turn enhance the lifetime of the devices. However, such devices require either intermittent surgeries to replace discharged batteries, or special and bulky wireless power setups, which limit experimental options as well as the scalability of animal experiments.
“This powerful device eliminates the need for additional painful surgeries to replace an exhausted battery in the implant, allowing seamless chronic neuromodulation,” said Professor Jeong. “We believe that the same basic technology can be applied to various types of implants, including deep brain stimulators, and cardiac and gastric pacemakers, to reduce the burden on patients for long-term use within the body.”
To enable wireless battery charging and controls, researchers developed a tiny circuit that integrates a wireless energy harvester with a coil antenna and a Bluetooth low-energy chip. An alternating magnetic field can harmlessly penetrate through tissue, and generate electricity inside the device to charge the battery. Then the battery-powered Bluetooth implant delivers programmable patterns of light to brain cells using an “easy-to-use” smartphone app for real-time brain control.
“This device can be operated anywhere and anytime to manipulate neural circuits, which makes it a highly versatile tool for investigating brain functions,” said lead author Choong Yeon Kim, a researcher at KAIST.
Neuroscientists successfully tested these implants in rats and demonstrated their ability to suppress cocaine-induced behaviour after the rats were injected with cocaine. This was achieved by precise light stimulation of relevant target neurons in their brains using the smartphone-controlled LEDs. Furthermore, the battery in the implants could be repeatedly recharged while the rats were behaving freely, thus minimizing any physical interruption to the experiments.
“Wireless battery re-charging makes experimental procedures much less complicated,” said the co-lead author Min Jeong Ku, a researcher at Yonsei University’s College of Medicine.
“The fact that we can control a specific behaviour of animals, by delivering light stimulation into the brain just with a simple manipulation of smartphone app, watching freely moving animals nearby, is very interesting and stimulates a lot of imagination,” said Jeong-Hoon Kim, a professor of physiology at Yonsei University’s College of Medicine. “This technology will facilitate various avenues of brain research.”
The researchers believe this brain implant technology may lead to new opportunities for brain research and therapeutic intervention to treat diseases in the brain and other organs.
This work was supported by grants from the National Research Foundation of Korea and the KAIST Global Singularity Research Program.
-Profile
Professor Jae-Woong Jeong
https://www.jeongresearch.org/
School of Electrical Engineering
KAIST
2021.01.26 View 23304 -
Professor Bumjoon Kim Named Scientist of the Month
Professor Bumjoon Kim from the Department of Chemical and Biomolecular Engineering won January’s Scientist of the Month Award presented by the Ministry of Science and ICT (MSIT) and the National Research Foundation of Korea (NRF) on January 6. Professor Kim also received 10 million won in prize money.
Professor Kim was recognized for his research in the field of fuel cells. Since the first paper on fuel cells was published in 1839 by the German chemist Friedrich Schonbein, there has been an increase in the number of fields in which fuel cells are used, including national defense, aerospace engineering, and autonomous vehicles.
Professor Kim developed carbonized block copolymer particles with high durability and a high-performance fuel cell. Block copolymers are two different polymers cross-linked into a chain structure. Various nanostructures can be made effectively by using the attractive and repulsive forces between the chains.
Professor Kim used the membrane emulsification technique, employing a high-performance separation membrane to develop a platform that makes the mass production of highly durable carbonized particles possible, which he then used to develop high-performance energy devices like fuel cells.
The carbonized particles designed by Professor Kim and his research team were used to create the world’s more durable fuel cells that boast outstanding performance while using only five percent of the costly platinum needed for existing commercialized products.
The team’s research results were published in the Journal of the American Chemical Society and Energy Environmental Science in May and July of last year.
“We have developed a fuel cell that ticks all the boxes including performance, durability, and cost,” said Professor Kim. “Related techniques will not be limited to fuel cells, but could also be applied to the development of various energy devices like solar cells and secondary cells,” he added.
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2021.01.22 View 9735 -
Expanding the Biosynthetic Pathway via Retrobiosynthesis
- Researchers reports a new strategy for the microbial production of multiple short-chain primary amines via retrobiosynthesis. -
KAIST metabolic engineers presented the bio-based production of multiple short-chain primary amines that have a wide range of applications in chemical industries for the first time. The research team led by Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering designed the novel biosynthetic pathways for short-chain primary amines by combining retrobiosynthesis and a precursor selection step.
The research team verified the newly designed pathways by confirming the in vivo production of 10 short-chain primary amines by supplying the precursors. Furthermore, the platform Escherichia coli strains were metabolically engineered to produce three proof-of-concept short-chain primary amines from glucose, demonstrating the possibility of the bio-based production of diverse short-chain primary amines from renewable resources. The research team said this study expands the strategy of systematically designing biosynthetic pathways for the production of a group of related chemicals as demonstrated by multiple short-chain primary amines as examples.
Currently, most of the industrial chemicals used in our daily lives are produced with petroleum-based products. However, there are several serious issues with the petroleum industry such as the depletion of fossil fuel reserves and environmental problems including global warming. To solve these problems, the sustainable production of industrial chemicals and materials is being explored with microorganisms as cell factories and renewable non-food biomass as raw materials for alternative to petroleum-based products. The engineering of these microorganisms has increasingly become more efficient and effective with the help of systems metabolic engineering – a practice of engineering the metabolism of a living organism toward the production of a desired metabolite. In this regard, the number of chemicals produced using biomass as a raw material has substantially increased.
Although the scope of chemicals that are producible using microorganisms continues to expand through advances in systems metabolic engineering, the biological production of short-chain primary amines has not yet been reported despite their industrial importance. Short-chain primary amines are the chemicals that have an alkyl or aryl group in the place of a hydrogen atom in ammonia with carbon chain lengths ranging from C1 to C7. Short-chain primary amines have a wide range of applications in chemical industries, for example, as a precursor for pharmaceuticals (e.g., antidiabetic and antihypertensive drugs), agrochemicals (e.g., herbicides, fungicides and insecticides), solvents, and vulcanization accelerators for rubber and plasticizers. The market size of short-chain primary amines was estimated to be more than 4 billion US dollars in 2014.
The main reason why the bio-based production of short-chain primary amines was not yet possible was due to their unknown biosynthetic pathways. Therefore, the team designed synthetic biosynthetic pathways for short-chain primary amines by combining retrobiosynthesis and a precursor selection step. The retrobiosynthesis allowed the systematic design of a biosynthetic pathway for short-chain primary amines by using a set of biochemical reaction rules that describe chemical transformation patterns between a substrate and product molecules at an atomic level.
These multiple precursors predicted for the possible biosynthesis of each short-chain primary amine were sequentially narrowed down by using the precursor selection step for efficient metabolic engineering experiments.
“Our research demonstrates the possibility of the renewable production of short-chain primary amines for the first time. We are planning to increase production efficiencies of short-chain primary amines. We believe that our study will play an important role in the development of sustainable and eco-friendly bio-based industries and the reorganization of the chemical industry, which is mandatory for solving the environmental problems threating the survival of mankind,” said Professor Lee.
This paper titled “Microbial production of multiple short-chain primary amines via retrobiosynthesis” was published in Nature Communications. This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT through the National Research Foundation (NRF) of Korea.
-Publication
Dong In Kim, Tong Un Chae, Hyun Uk Kim, Woo Dae Jang, and Sang Yup Lee. Microbial production of multiple short-chain primary amines via retrobiosynthesis. Nature Communications ( https://www.nature.com/articles/s41467-020-20423-6)
-Profile
Distinguished Professor Sang Yup Lee
leesy@kaist.ac.kr
Metabolic &Biomolecular Engineering National Research Laboratory
http://mbel.kaist.ac.kr
Department of Chemical and Biomolecular Engineering
KAIST
2021.01.14 View 10259 -
A Biological Strategy Reveals How Efficient Brain Circuitry Develops Spontaneously
- A KAIST team’s mathematical modelling shows that the topographic tiling of cortical maps originates from bottom-up projections from the periphery. -
Researchers have explained how the regularly structured topographic maps in the visual cortex of the brain could arise spontaneously to efficiently process visual information. This research provides a new framework for understanding functional architectures in the visual cortex during early developmental stages.
A KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering has demonstrated that the orthogonal organization of retinal mosaics in the periphery is mirrored onto the primary visual cortex and initiates the clustered topography of higher visual areas in the brain.
This new finding provides advanced insights into the mechanisms underlying a biological strategy of brain circuitry for the efficient tiling of sensory modules. The study was published in Cell Reports on January 5.
In higher mammals, the primary visual cortex is organized into various functional maps for neural tuning such as ocular dominance, orientation selectivity, and spatial frequency selectivity. Correlations between the topographies of different maps have been observed, implying their systematic organizations for the efficient tiling of sensory modules across cortical areas.
These observations have suggested that a common principle for developing individual functional maps may exist. However, it has remained unclear how such topographical organizations could arise spontaneously in the primary visual cortex of various species.
The research team found that the orthogonal organization in the primary visual cortex of the brain originates from the spatial organization in bottom-up feedforward projections. The team showed that an orthogonal relationship among sensory modules already exists in the retinal mosaics, and that this is mirrored onto the primary visual cortex to initiate the clustered topography.
By analyzing the retinal ganglion cell mosaics data in cats and monkeys, the researchers found that the structure of ON-OFF feedforward afferents is organized into a topographic tiling, analogous to the orthogonal intersection of cortical tuning maps.
Furthermore, the team’s analysis of previously published data collected on cats also showed that the ocular dominance, orientation selectivity, and spatial frequency selectivity in the primary visual cortex are correlated with the spatial profiles of the retinal inputs, implying that efficient tiling of cortical domains can originate from the regularly structured retinal patterns.
Professor Paik said, “Our study suggests that the structure of the periphery with simple feedforward wiring can provide the basis for a mechanism by which the early visual circuitry is assembled.”
He continued, “This is the first report that spatially organized retinal inputs from the periphery provide a common blueprint for multi-modal sensory modules in the visual cortex during the early developmental stages. Our findings would make a significant impact on our understanding the developmental strategy of brain circuitry for efficient sensory information processing.”
This work was supported by the National Research Foundation of Korea (NRF).
Image credit: Professor Se-Bum Paik, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Song, M, et al. (2021) Projection of orthogonal tiling from the retina to the visual cortex. Cell Reports 34, 108581. Available online at https://doi.org/10.1016/j.celrep.2020.108581
Profile:
Se-Bum Paik, Ph.D
Assistant Professor
sbpaik@kaist.ac.kr
http://vs.kaist.ac.kr/
VSNN Laboratory
Department of Bio and Brain Engineering
Program of Brain and Cognitive Engineering
http://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea
Profile:
Min Song
Ph.D. Candidate
night@kaist.ac.kr
Program of Brain and Cognitive Engineering
Profile:
Jaeson Jang, Ph.D.
Researcher
jaesonjang@kaist.ac.kr
Department of Bio and Brain Engineering, KAIST
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2021.01.14 View 6899