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Professor Moon Song Chun appointed representative director of European IT society
Professor Moon Song Chun from the College of business at KAIST was appointed as the representative director of Asia for the European IR society EUROMICRO at its 35th general meeting in Lille, France.
Professor Moon is highly regarded in his work in popularization of IT in 3rd world countries and has published the largest number of papers in the history of EUROMICRO. For the next two years, Professor Moon will work to introduce Asia’s IT capabilities to the world and to increase the recognition of the society in the region.
Professor Moon, who is also known as the first Computer Science Doctor (PhD) in Korea, has worked to popularize IT by initiating IT volunteer services in Africa, the Middle East, Central and South America, South East Asia and Eastern Europe. He has also helped in the recognition of Korea’s IT capacity, working as a Korean Delegate for the UN International Y2K Cooperation Center, a Distinguished Scholar at Hungarian Academy of Sciences, and a Visiting Scholar at Cambridge University.
2012.09.25 View 8206 -
Distinguished Professor Lee Sang Yeop Appointed as Fellow of the American Institute of Chemical Engineers
Professor Lee Sang Yeop (Dean of the Department of Biological Sciences) has become the first Korea Scientist to be appointed as the Fellow of the American Institute of Chemical Engineers.
The American Institute of Chemical Engineers was founded in 1908 and boasts a 100 year history. It is composed of 43,000 members over 90 countries and is the largest international Academic Institute in the field of Chemical Engineering.
The Institute appoints Fellows after a rigorous procedure of recommendation and evaluation and Professor Lee is the first Korean to become a Fellow.
Professor Lee’s expertise is the field of Metabolic Engineering and successfully applied the system design method and optimization strategy of chemical engineering to biological systems thereby developing numerous core technologies for the biology based chemical industries.
Professor Lee is the founder of the System Metabolic Engineering and enabled the medical application of microorganisms by manipulating the metabolic pathways on a systems level in addition to making great progress in synthesizing various oil originated chemical materials using biology based, environmentally friends methods.
Professor Lee received the Marvin J. Johnson Award, Charles Thom Award, and has been appointed by the first Chairman of the Biotech Global Agenda Counsel of the World Economic Forum.
2012.09.22 View 8326
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Professor Yoon Dong Ki becomes first Korean to Receive the Michi Nakata Prize
Professor Yoon Dong Ki (Graduate School of Nano Science and Technology) became the first Korean to receive the Michi Nakata Prize from the International Liquid Crystal Society.
The Awards Ceremony was held on the 23rd of August in Mainz, Germany in the 24th Annual International Liquid Crystal Conference.
The Michi Nakata Prize was initiated in 2008 and is rewarded every two years to a young scientist that made a ground breaking discovery or experimental result in the field of liquid crystal. Professor Yoon is the first Korean recipient of the Michi Nakata Prize.
Professor Yoon is the founder of the patterning field that utilizes the defect structure formed by smectic displays. He succeeded in large scale patterning complex chiral nano structures that make up bent-core molecules.
Professor Yoon’s experimental accomplishment was published in the Advanced Materials magazine and the Proc. Natl. Acad. Sci. U.S.A. and also as the cover dissertation of Liquid Crystals magazine.
Professor Yoon is currently working on Three Dimensional Nano Patterning of Supermolecular Liquid Crystal and is part of the World Class University organization.
2012.09.11 View 11261
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Jellyfish removal robot developed
Professor Myung Hyun’s research team from the Department of Civil and Environmental Engineering at KAIST has developed a jellyfish removal robot named ‘JEROS’ (JEROS: Jellyfish Elimination RObotic Swarm).
With jellyfish attacks around the south-west coast of Korea becoming a serious problem, causing deaths and operational losses (around 3 billion won a year), Professor Myung’s team started the development of this unmanned automatic jellyfish removal system 3 years ago.
JEROS floats on the surface of the water using two long cylindrical bodies. Motors are attached to the bodies such that the robot can move back and forth as well as rotate on water. A camera and GPS system allows the JEROS to detect jellyfish swarm as well as plan and calculate its work path relative to its position.
The jellyfish are removed by a submerged net that sucks them up using the velocity created by the unmanned sailing. Once caught, the jellyfish are pulverized using a special propeller.
JEROS is estimated to be 3 times more economical than manual removal. Upon experimentation, it showed a removal rate of 400kg per hour at 6 knots. To reach similar effectiveness as manual net removal, which removes up to 1 ton per hour, the research team designed the robot such that 3 or more individual robots could be grouped together and controlled as one.
The research team has finished conducting removal tests in Gunsan and Masan and plan to commercialize the robot next April after improving the removal technology. JEROS technology can also be used for a wide range of purposes such as patrolling and guarding, preventing oil spills or removing floating waste. This research was funded by the Ministry of Education, Science and Technology since 2010.
2012.08.29 View 11181
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First Annual CanSat Idea Exhibition held
The Ministry of Education, Science, and Technology held the ‘CanSat’ Exhibition in order to increase interest and understanding of satellites in primary, secondary, and high school level students.
The exhibition, hosted by KAIST Satellite Research Center and funded by Korea Aerospace Institute, was held in SaeJeong City.
90 primary, secondary school teams, 57 high school teams, and 14 university teams submitted their applications for participation. Of these teams 20 primary, secondary school teams, 5 high school teams, and 5 university teams were selected after thorough document valuation and presentation assessment.
The 20 primary, secondary school teams participated in the science camp to gain firsthand experience in the construction and launch of a simple satellite system.
The high school and university teams were evaluated by the level of completion of the task given and the level of creativity involved.
The CanSat Exhibition has been held in aerospace powerhouses and this was the first time such an exhibition was held in Korea.
2012.08.21 View 8260
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Graduate School of Culture and Technology Begins Mobile Science Classroom
KAIST Graduate School of Culture and Technology plans visits to elementary schools without the facilities to facilitate hands on science education.
The Graduate School of Culture and Technology planned the ‘STEAM Creative Camp’ involving three elementary schools during the summer holidays.
The ‘STEAM Creative Camp’ involves increasing interest and artistic sensitivity through experience based science education.
The program is composed of two separate programs in consideration to the level of participating students.
The beginner level program includes: code making, writing secret letters, sticker decorating program and the moderate level program includes: making wipers using complex pulley system, catapult design using elasticity, and puppet show using joints to animate.
The programs will be taught by masters and doctorate program candidates from the KAIST Youth Culture and Technology Experience Center.
*STEAM: And integrated education system including Science, Technology, Engineering, Arts, and Mathematics.
2012.07.26 View 8284
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Systems biology demystifies the resistance mechanism of targeted cancer medication
Korean researchers have found the fundamental resistance mechanism of the MEK inhibitor, a recently highlighted chemotherapy method, laying the foundation for future research on overcoming cancer drug resistance and improving cancer survival rates. This research is meaningful because it was conducted through systems biology, a fusion of IT and biotechnology.
The research was conducted by Professor Gwang hyun Cho’s team from the Department of Biology at KAIST and was supported by the Ministry of Education, Science and Technology and the National Research Foundation of Korea.
The research was published as the cover paper for the June edition of the Journal of Molecular Cell Biology (Title: The cross regulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor).
Targeted anticancer medication targets certain molecules in the signaling pathway of the tumor cell and not only has fewer side effects than pre-existing anticancer medication, but also has high clinical efficacy. The technology also allows the creation of personalized medication and has been widely praised by scientists worldwide.
However, resistances to the targeted medication have often been found before or during the clinical stage, eventually causing the medications to fail to reach the drug development stage. Moreover, even if the drug is effective, the survival rate is low and the redevelopment rate is high.
An active pathway in most tumor cells is the ERK (Extracellular signal-regulated kinases) signaling pathway. This pathway is especially important in the development of skin cancer or thyroid cancer, which are developed by the mutation of the BRAF gene inside the path. In these cases, the MEK (Extracellular signal-regulated kinases) inhibitor is an effective treatment because it targets the pathway itself. However, the built-up resistance to the inhibitor commonly leads to the redevelopment of cancer.
Professor Cho’s research team used large scale computer simulations to analyze the fundamental resistance mechanism of the MEK inhibitor and used molecular cell biological experiments as well as bio-imaging* techniques to verify the results.
* Bio-imaging: Checking biological phenomena at the cellular and molecular levels using imagery
The research team used different mutational variables, which revealed that the use of the MEK inhibitor reduced the transmission of the ERK signal but led to the activation of another signaling pathway (the PI3K signaling pathway), reducing the effectiveness of the medication. Professor Cho’s team also found that this response originated from the complex interaction between the signaling matter as well as the feedback network structure, suggesting that the mix of the MEK inhibitor with other drugs could improve the effects of the targeted anticancer medication.
Professor Cho stated that this research was the first of its kind to examine the drug resistivity against the MEK inhibitor at the systematic dimension and showed how the effects of drugs on the signaling pathways of cells could be predicted using computer simulation. It also showed how basic research on signaling networks can be applied to clinical drug use, successfully suggesting a new research platform on overcoming resistance to targeting medication using its fundamental mechanism.
2012.07.06 View 10492
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New wireless charging device developed
The On-line Electric Vehicle (OLEV) developed by KAIST has made a step towards commercialization with the development of a more economic wireless charging device.
Professor Chun-Taek Rim from the Department of Nuclear and Quantum Engineering at KAIST has developed a new I-shaped wireless charging device that differs from the pre-existing rail-type electricity feeder. This device can be modularly produced and requires relatively less construction, significantly reducing the cost of implementation.
The KAIST OLEV is a new concept electric car that has a special electricity collecting device underneath it. The car’s battery is charged by magnetic fields produced from electric lines buried 15cm underneath the road. The vehicle was first tested in 2009, making it the first wireless electric car in the world. OLEV can be charged during stoppage time between traffic lights and receives real-time power when running. OLEV is currently in operation at the KAIST Munji Campus in Daejeon and is also being exhibited at the Yeosu Expo and Seoul Grand Park.
The device itself has a charging capacity of 15kW, and the electricity is supplied through an electricity feeder with a width of 80cm with a space interval of 20cm. Despite being hailed as a technological breakthrough and revolutionary concept, KAIST OLEV has been criticized for problems in commercialization, due to the difficulties in installing wires beneath existing roads, which costs a considerable amount of money.
The new I-shaped wireless charging device reduces the width of the electricity feeder by 10cm, a mere one-eighth of the size of the previous version, and greatly increases the charging power to 25kW. Furthermore, the left and right permissible space of automobiles has increased to 24cm and the magnetic field complies with the international design guidelines, making the OLEV safe for the human body.
The reduction of the width has made the mass production of modules possible, making the installation of KAIST OLEV more economical and marketable. Professor Rim emphasized that compared with the existing rail-type electricity feeder, the new technology will need only one-tenth of the construction time and 80% of the cost, significantly improving OLEV’s constructability and workability.
The research was published in the IEEE Transactions on Power Electronics last December, and Professor Rim was invited to talk at the Conference on Electric Roads & Vehicles, which was held in February in the United States, about the new technology.
2012.07.06 View 10796
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The hereditary factor of autism revealed
Korean researchers have successfully investigated the causes and hereditary factors for autistic behavior and proposed a new treatment method with fewer side effects.
This research was jointly supported by the Ministry of Education, Science and Technology and the National Research Foundation as part of the Leading Researcher and Science Research Center Program
The research findings were publishing in the June edition of Nature magazine and will also be introduced in the July edition of Nature Reviews Drug Discovery, under the title ‘Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function’.
The research team found that lack of Shank2 genes in mice, which are responsible for the production of synapse proteins, caused autistic-like behavior. The results strongly suggested that the Shank2 gene was linked to autistic behavior and that Shank2 deficiency induced autistic behaviors.
Autism is a neural development disorder characterized by impaired social interaction, repetitive behavior, mental retardation, anxiety and hyperactivity. Around 100 million people worldwide display symptoms of autistic behavior. Recent studies conducted by the University of Washington revealed that 1 out of 3 young adults who display autistic behavior do not fit into the workplace or get accepted to college, a much higher rate than any other disorder. However, an effective cure has not yet been developed and current treatments are limited to reducing repetitive behavior.
The research team confirmed autistic-like social behavior in mice without the Shank2 genes and that the mice had decreased levels of neurotransmission in the NMDA receptor. The mice also showed damaged synaptic plasticity* in the hippocampus**.
* Plasticity: ability of the connectionbetween two neurons to change in strength in response to transmission of information
**Hippocampus: part of the brain responsible for short-term and long-term memory as well as spatial navigation.
The research team also found out that, to restore the function of the NMDA receptor, the passive stimulation of certain receptors, such as the mGLuR5, yielded better treatment results than the direct stimulation of the NMDA. This greatly reduces the side effects associated with the direct stimulation of receptors, resulting in a more effective treatment method.
This research successfully investigated the function of the Shank2 gene in the nerve tissue and showed how the reduced function of the NMDA receptor, due to the lack of the gene, resulted in autistic behavior. It also provided new possibilities for the treatment of autistic behavior and impaired social interaction
2012.06.24 View 10823
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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers.
*Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes.
Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions).
Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease.
Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease.
Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases.
However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself.
Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases.
The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases.
It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems.
The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30 View 11762
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Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11725
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KAIST College of Business ranks no.1 in Asia for executive education
KAIST College of Business ranked 28th in the world and 1st in Asia in the UK Financial Times (FT) 2012 Executive Education open ranking, making it the only school in Korea to be included.
The FT ranking selects the world’s top 65 business graduate schools based on executive education course design, teaching methods & materials, faculty, new skills & learning, quality of participants, and several other criteria. Last year, the KAIST executive education program ranked 29th in the world and 2nd in Asia. This year, it surpassed China’s CEIBS to rank 1st in Asia and has now been included in the ranking for three consecutive years.
Looking at the individual criteria, KAIST ranked highly in course preparation (11th), international location (11th), facilities (12th), and follow-up (5th) and saw increases in aims achieved (31st) and course design (29th).
KAIST attributed its success to the differentiation and specialization of education courses based on position, industry, and enterprise. KAIST College of Business operates an integrative course that fuses business management with science & technology, information media, medicine and innovation. The school runs both a chief and junior executive program to cater to different positional needs and provides specialized lectures that consider a company’s industry and size.
The ‘international location’ criteria saw a huge leap from 23rd to 11th due to the use of both long term and short term overseas exchange programs. The ‘Global Leader’ course created in 2011 is taught only in English and allows students to study abroad in a partner school in the second semester. The college’s knowhow in the MBA program also achieved recognition with high rankings in new skills & learning (18th) as well as in teaching methods & materials (24th).
College of Business President Lee Byung Tae said that the school’s success was achieved through a specialized curriculum that considers the market and explained that the ranking reflects the school’s competitiveness. He also said that KAIST will continue to provide the best educational services appropriate for KAIST’s outstanding reputation.
In the overall ranking, Swiss IMD was ranked number 1, followed by the Harvard Business School. In Asia, China’s CEIBS (29th), Singapore’s Aalto University (42nd), and the National University of Singapore Business School (64th) followed suit.
2012.05.17 View 9136