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New Structural Insight into Neurodegenerative Disease
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. Mutations in Ataxin-1 cause the neurological disease, Spinocerebella Ataxia Type 1 (SCA1), which is characterized by a loss of muscular coordination and balance (ataxia), as is seen in Parkinson’s, Alzheimer’s, and Huntington’s diseases.
SCA1-causing mutations in the ATAXIN1 gene alter the length of a glutamine stretch in the Ataxin-1 protein. The research team provides the first structural insight into the complex formation of ATAXIN-1 with its binding partner, Capicua (CIC). The team, led by Professor Ji-Joon Song from the Department of Biological Sciences at KAIST, solved the structure of Ataxin-1 and CIC complex in atomic level revealing molecular details of the interaction between Ataxin-1 and CIC.
Professor Song explained his recent research work,
“We are able to see the intricate process of complex formation and reconfiguration of the two proteins when they interact with each other. Our work, we expect, will provide a new therapeutic target to modulate SCA1 neurodegenerative disease.”
Understanding structural and molecular details of proteins at the atomic level will help researchers to track the molecular pathogenesis of the disease and, ultimately, design targeted therapies or treatments for patients, rather than just relieving the symptoms of diseases.
Professor Song’s research paper, entitled “Structural Basis of Protein Complex Formation and Reconfiguration by Polyglutamine Disease Protein ATAXIN-1 and Capicua,” will be published in the March 15th issue of Genes & Development (www.genesdev.org).
Complex Formation and Reconfiguration of ATAXIN-1 and Capicua
The complex formation between a polyglutamine disease protein, ATXIN-1 and the transcriptional repressor Capicua (CIC) plays a critical role in SCA 1 pathogenesis. The image shows that the homodimerization of ATXIN-1 (yellow and red) is disrupted upon binding of CIC (blue). Furthermore, the binding of CIC to the ATXIN-1 induces a new form of ATXIN-1 dimerization mediated by CICs (ATXIN-1 AXH domains are shown in yellow and red, and CIC peptides shown in blue and white).
2013.04.02 View 8523 -
The 6th president of KAIST passed away on May 7, 2010.
Dr. Sang-Soo Lee was the first president of Korea Advanced Institute of Science (KAIS) and the 6th president of KAIST, who died of a chronic disease at the age of 85. The KAIS was the matrix of KAIST today. Graduated from the physics department of Seoul National University in 1949, he later received a doctoral degree in optics from Imperial College of Science and Technology, University of London.
Dr. Lee has greatly contributed to the development of science and technology in Korea in the capacity of a policy administrator, educator, scientist, researcher, and engineer. He held numerous prestigious offices including President of Korea Atomic Energy Research Institute in 1967, of KAIS in 172, and of KAIST in 1989. Dr. Lee also worked as a professor at the physics department of KAIST for 20 years from 1972-1992.
The Society of Photographic Instrumentation Engineers (SPIE), an international society for optics and photonics, was founded in 1955 to advance light-based technologies. Dr. Sang-Soo Lee was a member of the SPIE that issued a news release expressing its sincere condolences to his death. The following is the full text of the news release: http://spie.org/x40527.xml
In memoriam: Sang Soo Lee
10 May 2010
Sang Soo Lee, known as the "Father of Optics" in Korea passed away on May 7, 2010, in Korea. He was 84.
Lee received a B.S. in Physics from Seoul National University in Korea and a Ph.D. from Imperial College of Science and Technology, University of London, UK. Receiving the first Ph.D. in Optics in Korea, Dr. Lee devoted his life to lay the foundation for optical science and engineering for more than four decades as an educator, researcher, and administrator in science policy.
"He was one of the architects of the extraordinary and rapid emergence of Korea as a world leader in science and technology, or perhaps with the rich history of contributions centuries ago, re-emergence would be more appropriate." said Eugene G. Arthurs, SPIE Executive Director.
During his teaching career, Dr. Lee mentored 50 doctoral and more than 100 masters" degree candidates. in the areas of laser physics, wave optics, and quantum optics. Many of his former students have become leaders in academia, government-funded research institutes, and industry both in Korea and abroad. He published more than 250 technical papers and authored five textbooks, including "Wave Optics", "Geometrical Optics", "Quantum Optics", and "Laser Speckles and Holography".
Lee was the first president of the Korea Advanced Institute of Science and Technology (KAIST), and the first president to establish a new government funded graduate school. He played a pivotal role in founding the Optical Society of Korea (OSK) in 1989 and served as its first president.
Lee was an active member of the international scientific community. In addition to his pioneering scholastic achievements at KAIST, he served as the Vice President of the International Commission for Optics (ICO), a Council Member of the Third World Academy of Sciences, and a Council Member of UN University, serving as an ambassador for the optics community, which showed a significant example of how a developing country like Korea can serve international optics community.
Dr. Lee was a Fellow of the International Society for Optical Engineering (SPIE), the Optical Society of America (OSA), and the Korean Physical Society (KPS). He was the recipient of many awards and honors, including the National Order of Civil Merit that is the Presidential Medal of Honor from the Republic of Korea (2000), the Songgok Academic Achievement Prize, the Presidential Award for Science, and the Medal of Honor for Distinguished Scientific Achievement in Korea. In 2006, he was awarded OSA"s Esther Hoffman Beller Medal.
2010.05.19 View 12766 -
Int'l Telematic Music Concert for Peace to Take Place on Nov. 20
Renowned musicians in five international locations perform new contemporary music works for peace through a real-time performance on the internet. Local audiences in Seoul, Banff, New York, San Diego and Belfast will also have a chance to hear a program.
In Seoul, the "International Telematic Music Concert for Peace" will be held at the LeeHaeRang Art Theater, Dongguk University, in Seoul on Nov. 20 at 9:30 a.m., under the presentation of KAIST"s Graduate School of Culture Technology and MARTE Lab, Dongguk University. Telematic music is real-time performance via the internet by musicians in different geographic locations.
The program of the concert includes "Hope"s Dream" by Mark Dresser and Sarah Weaver; "Disparate Bodies" by Pedro Rebelo, "Rock, Paper, Scissors" by Chris Chafe. The Korean act to be performed is "Green-colored Harmony" by Jun Kim.
In addition to the two Korean universities, the World Association of Former United Nations Internes and Fellows (WAFUNIF), University of California San Diego, the Banff Center of Canada and Queen"s University in Belfast are participating in the project.
The performance will take place on high-bandwidth internet with JackTrip audio software developed by Chris Chafe and Access Grid video software developed at Argonne National Laboratory.
"Connecting the five different cities together through super-speed Internet network and transmitting sound and images in real time is challenging technically. But, we also expect that more exciting results will be created in the course of transforming the sound into visual images," said Woon-Seung Yeo, a professor of the Graduate School of Culture Technology, who was responsible for visuals in the project.
2009.11.19 View 12366 -
U.S. Nobel Laureate to Run Korea's Top Tech University
Robert Laughlin,
President of the Korea Advanced Institute of Science and Technology (KAIST)
DAEJEON, July 14 (Yonhap) -- Nobel Physics Prize laureate Robert Laughlin was sworn in Wednesday as the first foreign president of the Korea Advanced Institute of Science and Technology (KAIST), South Korea"s top technology university.
Laughlin, in his inauguration speech, pledged to transform the state-run Korean university into a globally competitive educational institution, while also vowing to make it research oriented.
"Many people have asked me how I, as a foreigner, could possibly understand the situation here at KAIST, much less figure out a path forward," he said. "The short answer is that the situation here is not unique. The problems facing the research university are historical in nature and essentially identical all over the world."
He added the same worried discussions are taking place in other universities around the globe such as at Stanford, the Massachusetts Institute of Technology, Heidelberg and Tokyo.
"I have come here not to solve your problems but to solve my own," the 54-year-old American said.
Laughlin said KAIST is a large, well-functioning organization for which few things needed to be changed.
The former Stanford University professor also promised to work hard to lead the university in a novel direction.
"All of us in the technical university have a holy obligation ... we are here for the sole purpose of having big dreams and finding the strength to make them come to pass," Laughlin said.
"As far as I"m concerned, my job comes down to one thing: to make sure that your dreams are big enough, and to help everyone here -- faculty and students -- find the means to make them come to pass. That"s all," he said.
The ceremony was attended by Science and Technology Minister Oh Myung, Daejeon City Mayor Yeom Hong-chul and U.S. Ambassador to South Korea Thomas Hubbard, among others.
On Thursday, Laughlin is scheduled to meet President Roh Moo-hyun in Seoul. Laughlin will start his four-year term from mid-August, KAIST said.
Laughlin won the Nobel Prize for Physics in 1998 with Horst Stoermer of Germany and Daniel Tsui of the United States for discovering a new form of quantum fluid that gives more profound insights into the general inner structure and dynamics of matter.
On May 28, he was chosen to run the Korean university at a board meeting. (END)
2004.07.15 View 14363 -
Nobel Laureate Heads KAIST
Nobel Laureate Heads KAIST
By Kim Tae-gyu / Staff Reporter
THE KOREA TIMES 05-29-2004
A Nobel laureate will lead the Korea Advanced Institute of Science and Technology (KAIST), winning a stiff race with a pair of strong Korean candidates.
The KAIST on Friday said the state-financed institute appointed Robert Laughlin as its 12th president instead of two local hopefuls, professors Shin Seong-cheol and Park Seong-ju.
This is the first time that foreigners take charge of the KAIST since it was established in 1971 and Laughlin also is noted in the history as the first Nobel Prize winner to head Korea"s educational institute.
After receiving approval of Science-Technology Minister Oh Myung, Laughlin will be inaugurated as early as next month, according to a KAIST official.
Laughlin, a Stanford professor, made his name after being co-awarded the 1998 Nobel Prize in Physics with Horst Stoermer and Daniel Tsui for the discovery of a new form of quantum fluid.
The findings, which explained the fractional quantum hall effect for the first time, have been recognized as a significant breakthrough in understanding quantum physics.
The American physicist had also sustained a special connection with Korea even before he garnered the prestigious prize and has visited Korea several times.
Early last month, Laughlin was named to head the Asia Pacific Center for Theoretical Physics (APCTP) in recognition of his notable interest in Korea.
The APCTP is an international research institute headquartered inside Pohang University of Science and Technology in North Kyongsang Province.
voc200@koreatimes.co.kr
2004.05.31 View 17036