Engineering
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Prof. Lee"s Team Pioneers Biotechnological Production of Chemical Using Renewable Materials
A research team led by Prof. Sang-Yup Lee of the Bio and Brain Engineering Department at KAIST has succeeded in engineering the bacterium E. coli to produce the industrial chemical putrescine, university authorities said on Monday (Aug. 31).
Putrescine, a four carbon chain diamine, is an important platform chemical with a wide range of applications for the pharmaceutical, agrochemical and chemical industries. It is currently used to synthesize nylon-4,6, a widely used engineering plastic.
The research result, published in the Biotechnology and Bioengineering journal, proviDrdes a renewable alternative to the traditional process using fossil fuels.
Currently the production of putrescine on an industrial scale relies on chemical synthesis, which requires non-renewable petrochemicals and expensive catalyst systems. This process is highly toxic and flammable with potentially severe repercussions for both the environment and human health.
"For the first time we have developed a metabolically engineered E. coli strain that efficiently produces putrescine," said Professor Lee. "The development of a bio-refinery for chemicals and materials is very important in a world where dependency on fossil fuels is an increasing concern."
The team developed a strain of E.coli capable of producing putrescine through metabolic engineering. This is where a cell"s metabolic and regulatory networks are enhanced in order to increase production of a needed material.
First the team weakened or deleted competing metabolic pathways within the E. coli strain before deleting pathways which cause putrescine degradation. They also amplified the crucial enzyme Spec C, which converts the chemical ornithine into putrescine. Finally the putrescine exporter, which allows excretion of intracellularly made putrescine, was engineered while a global regulator was engineered to further increase the concentration of putrescine. The final result of this process was an engineered E.coli strain which produced 24.2 g of putrescine per litre.
However, as it was believed that putrescine is toxic to microorganisms the team had to study putrescine tolerance in E.coli before it could be engineered to overproduce the chemical to the levels needed for industrial production.
The results revealed that E. coli can tolerate at least 0.5 M of putrescine, which is tenfold higher than the usual concentration in the cell. This level of tolerance was an important surprise as it means that E. coli can be engineered to overproduce putrescine to industrially competitive levels.
"The previously expected toxicity of putrescine may explain why its microbial production has been overlooked," said Lee. "Now a metabolically engineered E. coli strain has been developed which is capable of efficiently producing putrescine using renewable methods to an industrial level. This metabolic engineering framework should be useful for developing metabolically engineered microorganisms for the efficient production of other chemicals from renewable resources," he added.
2009.09.01 View 12874 -
Transparent Antenna for Automobile Developed
A research team led by Prof. Jae-Woo Park of the School of Electrical Engineering & Computer Science, KAIST, developed a transparent antenna for the next-generation automobiles, university authorities said on Monday (Aug. 17).
The development was made possible through joint researches with the Hyundai-Kia Automotive Group; Winncom, a car antenna manufacturer; and a group of researchers led by Han-Ki Kim of the Department of Display Materials Engineering at Kyung Hee University in Seoul.
The transparent antennas were developed in two kinds -- one for the HSDPA (High-Speed Downlink Packet Access), a new protocol for mobile telephone data transmission, and the other for transmitting and receiving radio wave for emergency call.
Using the transparent electrically conductive film formation technology, the transparent antennas are to be mounted on the windshield of a vehicle.
"The development of transparent antenna represents a step forward for the advancement of the next-generation automotive electronic technology," said Seong-woo Kim, a senior researcher at the Hyundai-Kia Group.
2009.08.18 View 12320 -
KAIST College of Life Sciences and Bioengineering Signs MOU with Harvard
KAIST’s College of Life Sciences and Bioengineering recently signed a memorandum of understanding (MOU) with Harvard University’s Center for Brain Science on July 20, which will allow for joint research and exchange in researchers between the two institutions.
Headed by Director Kenneth Blum, Harvard’s Center for Brain Science leads the world in brain-related research. The new MOU will allow for research cooperation, exchanges of professors, researchers, and students, joint usage of infrastructure and research materials, and finally, sharing of research assignments.
The Dean of the College of Life Sciences and Bioengineering Sang Yup Lee, who concerted efforts to form the MOU said, “This agreement will bring together two of the world’s leading brain-related research teams, and I hope that combining their expertise will bring great advances in brain science and engineering.
KAIST’s College of Life Science and Bioengineering, which is known for its creative interdisciplinary research, is producing exemplary research results in the field of brain science from its Biological Sciences and Bio and Brain Engineering departments.
In addition to cooperation with Harvard, KAIST has also formed partnerships with Emory University, Japan’s RIKEN Brain Institute, and Germany’s Max Planck Institute. Not only does it have a worldwide network pertaining to brain research, but KAIST has also engaged in cooperative research with prominent domestic institutions such as, Asan Medical Center, the Korea Research Institute of Bioscience and Biotechnology, the Korea Research Institute of Standards and Science, and the SK Corporation. Through these connections, KAIST has managed to lead in mutually cooperative brain interdisciplinary research.
2009.08.10 View 14539 -
KAIST Professor Sang-Yup Lee Chair of International Metabolic Engineering Conference Due Next Year
KAIST distinguished professor Sang-Yup Lee was named to chair the 17th Metabolic Engineering Conference which will convene on Jeju Island, Korea, next year, under the theme of "Metabolic Engineering for Green Growth." It was decided at the 16th Biochemical Engineering Conference held in Burlington, Vermont, on July 5-9.
Metabolic Engineering Conference in 2010 will not only involve presentations and discussions about metabolic engineering, but will inaugurate the “World Council on Industrial Biotechnology,” which will bring together global corporations and the world’s experts in industrial biochemical engineering, according to sources at KAIST.
A KAIST official commented, “The fact that the Metabolic Engineering Conference is to be held here [in Korea] proves that Korea is being acknowledged as a key player in this field.”
As the world faces the depletion of fossil fuels and environmental pollution, nations are showing increasing interest in industrial biochemical alternatives, such as microscopic organisms or new chemicals, to solve their problems. In addition, efficient production of biochemical materials and bio-fuels using microbes is deemed vital for the future.
“The Korean government has become a model to other countries thanks to its leadership in carrying out the ‘Green Growth’ policy,” Professor Sang-Yup Lee said. He stated that KAIST is recognized for its research in advanced biochemical material and fuel production methods.
“Green Growth,” a concept first developed by ESCAP, the UN agency working for social and economic cooperation in Asia and the Pacific, aims to achieve sustainable economic growth without destroying the environment.
Ref. Department of Biochemical Engineering, Metabolic and BioMolecular Engineering Lab, KAIST
2009.07.17 View 12549 -
KAIST President Suh Honored with 2009 ASME Medal
KAIST President Nam-Pyo Suh has chosen as the 2009 winner of the ASME Medal presented by the American Society of Mechanical Engineers, university authorities said on Thursday (July 2).
President Suh received the honor for "seminal contributions to the advancement of engineering through research in tribology, polymer processing, metal processing, design and manufacturing, as well as contributions to engineering education and research infrastructure."
The selection of President Suh was unanimously approved by the 13-member Board of Governors of the ASME. Suh became the first scientist of Asian descent in the award"s 89-year-long history.
Founded in 1880, the ASME is a non-profit professional organization promoting the art, science and practice of mechanical and multidisciplinary engineering and allied sciences. The organization is known for setting codes and standards for mechanical devices. As of 2009, it has 120,000 members worldwide.
Only one ASME medal is awarded annually to recognize "eminently distinguished achievement." The award consists of a $17,000 honorarium, a gold medal, certificate and travel supplement for two days. It will be presented to President Suh during the 2009 International Mechanical Engineering Congress and Exposition, which will be held in Lake Buena Vista, Florida, November 13-10, 2009.
President Suh is an internationally known educator, engineer and inventor. Born in Korea, he immigrated to the U.S. in 1954 to join his father, who was teaching at Harvard. He earned both his bachelor"s and master"s degrees from MIT before coming to Carnegie Tech for his doctoral education in mechanical engineering.
While teaching at MIT, he founded the MIT-Industry Polymer Processing Program in 1973 and the Laboratory for Manufacturing and Productivity. He left these positions in 1984 to serve with the U.S. National Science Foundation as its assistant director for engineering, until 1988.
He invented many new materials, products and manufacturing processes, earning more than 60 U. S. patents and founding several companies. He has written seven books and more than 300 scholarly papers. Among dozens of honors throughout his career, President Suh most recently received the 2007 Lifetime Achievement from the Society of Plastics Engineers.
The ASME conducts one of the world"s largest technical publishing operations through its ASME Press, holds numerous technical conferences and hundreds of professional development courses each year, and sponsors numerous outreach and educational programs.
2009.07.02 View 12675 -
KAIST Dedicates Geocentrifuge Experiment Center
KAIST dedicated the KOCED Geo-Centrifuge Experiment Center for researches in monitoring natural disasters such as earthquake and embankment collapse through miniature simulation tests on Wednesday (April 9) after a two-year construction work.
The experiment center is part of the Korea Construction Engineering Development Collaboratory Program (KOCED) which has been sponsored by the Ministry of Land, Transport and Maritime Affairs to build an infrastructure for construction engineering researches at a national level. The ministry plans to build a total of 5 similar centers nationwide by the end of the year.
On hand at the dedication ceremony were Jae-Choon Lee, President of the Korea Institute of Construction & Transportation Technology Evaluation and Planning, KAIST President Nam-Pyo Suh, and scores of experts and administration officials.
The construction of the five-story building on an area of about 3,328 square meters cost 8.4 billion won (US$6.3 million).
The center is expected to serve as a major laboratory in the field of geotechnical engineering. It is equipped with such state-of-the-art facilities as geocentrifuge, a useful tool for studying flow in unsaturated soil under well-controlled, repeatable conditions, a bidirectional shaking-table that can reproduce earthquake-like wave; and robots that can reproduce construction procedures by remote control.
Geocentrifuge experiment allows detecting ground and structure motions easily and rapidly by simulation tests. Thus, it is widely used for various geotechnical engineering researches such as evaluation of seismic safety, soft ground movement, slope stability analysis, etc. The causes of the embankment collapse in New Orleans by Hurricane Katrina in 2005 were also revealed by the geocentrifuge experiment.
The geocentrifuge research facility is available for use by outside researchers, so scientists from other universities, research institutes and corporations can perform research and test their scientific and engineering hypotheses.
The center is divided into two sections, experiment building and research building. The experiment building is composed of a geocentrifuge laboratory, model-making rooms, workshops, a geotechnical engineering laboratory and specimen storehouse, while the research building has a control room, a video conference room, an electronic library and research rooms.
2009.04.09 View 12072 -
Respected Entrepreneur Chung Elected New Board Chairman of KAIST
Moon-Soul Chung, founder and former CEO of Mirae Corp. who is well known as the first-generation venture entrepreneur in Korea, was elected new chairman of the KAIST Board of Directors at the 193rd Regular Board Meeting held on March 20 in Seoul, school authorities announced Monday, March 23.
Born in 1938 in Imsil, North Jeolla Province, Chung graduated from the Oriental Philosophy Department of Won Kwang University. Chung founded Mirae Corp., a semiconductor equipment manufacturer, in 1983 and got his company listed on KOSDAQ and NASDAQ markets later. His business principles stressing transparency, integrity, and technology, earned the respect of Korean businesspeople.
In 2000, he suddenly announced retirement and handed over the presidency of his company to one of his managing directors. One year later, he donated 30 billion won to KAIST. It was by then the largest amount given by a single donor.
In 2007, he was awarded an honorary degree of doctor of engineering from KAIST. He formerly served as chairman of Venture Leaders Club, President CEO of Lycos Korea and chairman of the board of directors of Kookmin Bank.
2009.03.26 View 12413 -
Workshop on Biomedical IC to Be Held on March 26
KAIST will hold a workshop on "biomedical IC for future healthcare system" on March 26 at a lecture room of the School of Electrical Engineering & Computer Science. The workshop is organized by SEECS and the Korean Institute of Next Generation Computing.
At the workshop, a variety of new technologies expected to expedite the development of biomedical systems will be presented. KAIST Prof. Hoi-Jun Yoo will speak on the "body channel communication" using the human body as the signal transmission medium and Dr. Seung-Hwan Kim of Electronics and Telecommunications Research Institute (ETRI) on a wearable vital sign monitoring system.
Other subjects are CMOS (complementary metal-oxide semiconductor) fully electronic biosensor for biomolecular detection to be presented by KAIST Prof. Gyu-Hyeong Cho; nerve interface and IC (integrated circuit) system design by KAIST Prof. Yoon-gi Nam; design of neural recording and stimulation IC using time-varying magnetic field by KAIST Prof. Seong-Hwan Cho; low power multi-core digital signal processor for hearing aid by Dong-Wook Kim, senior researcher at the Samsung Advanced Institute of Technology; and a non-contact cardiac sensor by KAIST Prof. Seung-Chul Hong.
With the advent of the ageing society, medical expenses of the elderly people are rapidly increasing. As a way to address the issue, interests are growing in "ubiquitous healthcare," a technology that uses a large number of environmental and patient sensors and actuators to monitor and improve patients’ physical and mental condition.
The upcoming workshop is the first academic event on biomedical integrated chips to be held in Korea. The workshop will provide a valuable opportunity for experts in biomedical area to get together and examine the present status of Korean biomedical area and discuss about its future, KAIST officials said.
2009.03.20 View 16556
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Five KAIST Students Offered Internship from Qualcomm
Qualcomm Inc., a wireless telecommunications research and development company based in San Diego, California, has offered internship for five KAIST students of the Department of Electrical Engineering and Computer Science, university authorities said on Monday (Jan. 5).
The five students who are graduate and doctoral students studying communication and RFID (radio frequency identification) design will be working for six months at Qualcomm"s RFIC (radio frequency integrated circuits) Department in Santa Clara, Calif., as co-researchers. These interns will receive about $7,000 a month each with other benefits.
It is the first time that Qualcomm has offered internship for students outside the U.S., according to external relations officials at KAIST. Students who have shown outstanding research output during the internship period will be offered employment at Qualcomm.
"Qualcomm"s internship for KAIST students is designed to help young Korean talents to become professionals who will lead global advancement in the IT sector and strengthen its research network with Korea," Seung-Soo Kim, senior director of Qualcomm Korea, was quoted as saying.
Qualcomm plans to continue providing internship program for KAIST students, as well as pursuing joint research initiatives, the officials said.
2009.01.08 View 14144
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Prof. Seong Publishes English Book on Reliability in Digital Control Systems
Prof. Poong-Hyun Seong of Department of Nuclear and Quantum Engineering has recently published an English-language book on reliability and risk issues in large scale safety-critical digital control systems used in complex facilities such as nuclear power plants.
The book entitled “Reliability and Risk Issues in Large Scale Safety-critical Digital Control Systems” is a result of Prof. Seong’s collaboration with some KAIST graduates who used to be under his guidance. The 303-page publication has been published by Springer, one of the world’s leading publishers of academic journals, as part of the Springer Series in Reliability Engineering.
The book consists of four parts; part I deals with issues related to hardware, part II software, part III human factors and finally the last part integrated systems. It can be purchased through some on-line book stores such as Amazon.com.
Prof. Seong served as an editor-in-chief for Nuclear Engineering and Technology (NET), an international journal of Korean Nuclear Society (KNS), from 2003 to 2008. He also worked as a chair of the Human Factors Division (HFD) of American Nuclear Society (ANS) from 2006 to 2007. Prof. Seong is now a commissioner of Korea Nuclear Safety Commission which is the nation’s highest committee on Nuclear Safety.
2008.12.26 View 14951
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Prof. Cho Wins Best Paper Award
KAIST Prof. Nam-Zin Cho of the Department of Nuclear and Quantum Engineering, won the Best Thesis Award in the nuclear reactor physics category at the 2008 Winter Meeting of the American Nuclear Society held on Nov. 9-13 in Reno, Nevada.
His paper, entitled "Thermal Feedback Transient Analysis of a Pebble Fuel Based on the Two-Temperature Homogenized Model," was jointly authored by Hwi Yu and Jong-Un Kim under the guidance of Prof. Cho.
Prof. Cho was elected a fellow of the American Nuclear Society in 2001 and has served as the deputy editor of the Nuclear Science and Engineering, the research journal of the American Nuclear Society, since 1999.
2008.12.09 View 13288 -
2008 IEEE International Conference on Humanoid Robots Opens
The 2008 IEEE-RAS International Conference on Humanoid Robots, an international gathering to identify new research trends and technology in humanoid robotics, will open a three-day session on Monday (Dec. 1) at the Hotel Rivera and KAIST in Daejeon.
The annual conference is organized by KAIST and the Robotics and Automation Society of the Institute for Electric and Electronic Engineers, a U.S.-based international non-profit, professional organization for the advancement of technology related to electricity.
The conference is expected to draw a total of 200 robotics researchers from 19 different countries. Prof. Jun-Ho Oh, at the Department of Mechanical Engineering who led the creation of Korea"s first humanoid robot Hubo, is serving as general chair of the conference. Prof. Oh was named the host of the 2008 conference at the 2007 conference held at the Carnegie Melon University of the United States. The eight-year old conference was inaugurated in Boston in 2000.
On the opening day of Dec. 1, seven lectures will be given on diverse areas of robotics including cognitive humanoid vision, and robot vision sensor and sensing. On the subsequent two days, a total of 110 papers will be presented.
During the conference period, a variety of robots produced by six local and foreign robot makers will be on demonstration, providing opportunities for researchers and industrial robot makers to share technological ideas.
Highlights of the conference will be special lectures by world-renowned robot researchers Prof. Yoshiyuki Sankai of University of Tsukuba, who has created an exoskeletal "robot suit," and Prof. Art Kuo of Univerity of Michigan who is regarded as a leading authority in dynamic walking.
Following the conference, all participants are scheduled to tour Prof. Oh"s Hubo Lab and the Human-Robot Interaction Research Center, both located at KAIST.
2008.12.01 View 12699