bio
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New BioFactory Technique Developed using sRNAs
Professor Sang Yup Lee
- published on the online edition of Nature Biotechnology. “Expected as a new strategy for the bio industry that may replace the chemical industry.”-
KAIST Chemical & Biomolecular engineering department’s Professor Sang Yup Lee and his team has developed a new technology that utilizes the synthetic small regulatory RNAs (sRNAs) to implement the BioFactory in a larger scale with more effectiveness.
* BioFactory: Microbial-based production system which creates the desired compound in mass by manipulating the genes of the cell.
In order to solve the problems of modern society, such as environmental pollution caused by the exhaustion of fossil fuels and usage of petrochemical products, an eco-friendly and sustainable bio industry is on the rise. BioFactory development technology has especially attracted the attention world-wide, with its ability to produce bio-energy, pharmaceuticals, eco-friendly materials and more.
For the development of an excellent BioFactory, selection for the gene that produces the desired compounds must be accompanied by finding the microorganism with high production efficiency; however, the previous research method had a complicated and time-consuming problem of having to manipulate the genes of the microorganism one by one.
Professor Sang Yup Lee’s research team, including Dr. Dokyun Na and Dr. Seung Min Yoo, has produced the synthetic sRNAs and utilized it to overcome the technical limitations mentioned above.
In particular, unlike the existing method, this technology using synthetic sRNAs exhibits no strain specificity which can dramatically shorten the experiment that used to take months to just a few days.
The research team applied the synthetic small regulatory RNA technology to the production of the tyrosine*, which is used as the precursor of the medicinal compound, and cadaverine**, widely utilized in a variety of petrochemical products, and has succeeded developing BioFactory with the world’s highest yield rate (21.9g /L, 12.6g / L each).
*tyrosine: amino acid known to control stress and improve concentration
**cadaverine: base material used in many petrochemical products, such as polyurethane
Professor Sang Yup Lee highlighted the significance of this research: “it is expected the synthetic small regulatory RNA technology will stimulate the BioFactory development and also serve as a catalyst which can make the chemical industry, currently represented by its petroleum energy, transform into bio industry.”
The study was carried out with the support of Global Frontier Project (Intelligent Bio-Systems Design and Synthesis Research Unit (Chief Seon Chang Kim)) and the findings have been published on January 20th in the online edition of the worldwide journal Nature Biotechnology.
2013.02.21 View 11406 -
Professor Cho Young-ho wins 'E2 Star' award
Professor Cho Young-ho from the Department of Bio and Brain Engineering at KAIST was chosen as the ‘E2 Star’ at the ‘2012 Engineering Education Festa’ in academics. The ‘2012 Engineering Education Festa’ hosted by the Ministry of Education, Science and Technology was held to display outstanding research results and to conceptualize the future of science education.
The ‘E2 star’ award is given to renowned figures in industry, academia and society. A total of 35 candidates were recommended for the 3 fields and Professor Cho received the first place in the online voting.
Professor Cho received high marks for his work in engineering education, research development and increasing the communication between academia and industry, as well as the commercialization of science and technology. Professor Cho was especially praised for the specialization of engineering education in integrated fields and the joint research with US and Swiss universities.
Professor Cho Young-ho(Department of Bio and Brain Engineering, KAIST)
2012.12.26 View 10715 -
Distinguished Professor Lee Sang Yeop Appointed as Fellow of the American Institute of Chemical Engineers
Professor Lee Sang Yeop (Dean of the Department of Biological Sciences) has become the first Korea Scientist to be appointed as the Fellow of the American Institute of Chemical Engineers.
The American Institute of Chemical Engineers was founded in 1908 and boasts a 100 year history. It is composed of 43,000 members over 90 countries and is the largest international Academic Institute in the field of Chemical Engineering.
The Institute appoints Fellows after a rigorous procedure of recommendation and evaluation and Professor Lee is the first Korean to become a Fellow.
Professor Lee’s expertise is the field of Metabolic Engineering and successfully applied the system design method and optimization strategy of chemical engineering to biological systems thereby developing numerous core technologies for the biology based chemical industries.
Professor Lee is the founder of the System Metabolic Engineering and enabled the medical application of microorganisms by manipulating the metabolic pathways on a systems level in addition to making great progress in synthesizing various oil originated chemical materials using biology based, environmentally friends methods.
Professor Lee received the Marvin J. Johnson Award, Charles Thom Award, and has been appointed by the first Chairman of the Biotech Global Agenda Counsel of the World Economic Forum.
2012.09.22 View 9378
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Professor Kim Eun Joon receives In Chon Award
Professor Kim Eun Joon (Department of Biological Sciences) received the In Chon Awarded hosted by In Chon Memorial and Dong Ah Newspaper.
The Award Ceremony will be held on the 8th of October in Seoul Lotte Hotel and Professor Kim will be given a medal and prize money amounting 100million Korean Won.
Professor Kim is a world renowned research in the field of Synapses. Professor Kim graduated from the Department of Pharmacy in Pusan University, B.A. at KAIST, and Ph.D at Michigan University. He has been a Professor at KAIST since 2000.
2012.09.11 View 8397
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Distinguished Professor Sang-Yeop Lee gave keynote speech in '2011 China Bio-Refinery Summit'
Distinguished Professor Sang-Yeop Lee gave keynote speech in ‘2011 China Bio-Refinery Summit’ held in Chang’an, Beijing
Professor Lee gave a lecture on the vitalization strategy of ‘Bio-Refinery’, which is ‘A bio-based chemical industry to replace fossil fuel-based petro chemistry.
Professor Lee, insisted that for the successful construction of ‘Bio-Refinery’, there should be innovation in all value chain of biomass; biomass producer, bio-refinery business, consumer, government, etc. ▲Securement and distribution of Biomass ▲Development of strain and process for fermentation separation to effectively change biomass into chemical substance and fuel ▲Optimization of transportation and marketing.
During this summit, high-ranking government officials in politics and economics, executives of multicultural and Chinese business participated. From Korea, Do-Young Seung of Manager of technology research of GS and Hang-Deok Roh of laboratory chief of SK Chemical participated as panelist.
World Economy Forum, the gathering of leaders and experts in politics, economics, and policy created a ‘Global Agenda Council’ to find solutions on the issue of ‘sustainable growth of environment of the Earth and humanity’. Professor Lee is the chairperson of ‘Emerging Technologies Global Agenda Council (GAC)’ of Word Economy Forum.
Professor Lee, founder of ‘Systems Metabolic Engineering’, has made remarkable achievements world-wide, including a technology that manipulates metabolic circuit of microorganisms to purify various crude-originated chemical substances into environmentally friendly substances.
Currently, he is working on Systems biology research business in Ministry of Education, Science and Technology, Global Frontier Biomass business, Global Frontier Intelligent Bio-system construction and composition, to make progress in metabolic engineering which is essential for the bio-chemical industry.
2012.03.06 View 12225
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 9676
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The Hindu, "Use of microalgae helps in controlling pollution," December 8, 2011
The Hindu, an Indian newspaper, reported on December 8, 2011 a research work by Professor Ji-Won Yang from the Department of Chemical and Biomolecular Engineering. For the news article, please go to the link at http://www.thehindu.com/sci-tech/energy-and-environment/article2695634.ece?homepage=true.
The Hindu, December 8, 2011
Use of microalgae helps in controlling pollution
By N. Gopal Raj
2011.12.12 View 9743
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Professor Choi Chul Hui appointed as editor-in-chief of Nanobiosensors in a disease diagnosis magazine
Professor Choi Chul Hui of the Department of Biological and Brain Engineering has been appointed the editor-in-chief of Nanobiosensors, an international medical magazine that concentrates on disease diagnosis.
As the editor-in-chief, Professor Choi will be involved in dissertation evaluations and overall direction of the magazine.
Professor Choi is one of the leading authorities in the field of clinical medicine and has published 60 SCI level dissertations in the fields of cell biology, computational biology, and bio-optics.
He is also the executive director of the KAIST BioImaging Research Center, and his research lab focuses on cell signals and bio imaging. Professor Choi is researching the generation process of degenerative diseases like arteriosclerosis by taking a multidisciplinary approach.
Professor Choi has recently developed a new bio imaging technique that allows for the measurement of perfusion and a new technology for the drug delivery to nerves using ultra short wavelength laser beams.
2011.10.10 View 10754 -
Cancer detection from an implantable, flexible LED
Professor Keon Jae Lee
A KAIST research team has developed a new type of biocompatible and bendable GaN LED biosensor.
Daejeon, the Republic of Korea, August 8, 2011—Can a flexible LED conformably placed on the human heart, situated on the corrugated surface of the human brain, or rolled upon the blood vessels, diagnose or even treat various diseases? These things might be a reality in the near future.
The team of Professor Keon Jae Lee (Department of Materials Science and Engineering, KAIST) has developed a new concept: a biocompatible, flexible Gallium Nitride (GaN) LED that can detect prostate cancer.
GaN LED, a highly efficient light emitting device, has been commercialized in LED TVs and in the lighting industry. Until now, it has been difficult to use this semiconductor material to fabricate flexible electronic systems due to its brittleness. The research team, however, has succeeded in developing a highly efficient, flexible GaN LED and in detecting cancer using a flexible LED biosensor.
Prof. Lee was involved in the first co-invention of "High Performance Flexible Single Crystal GaN" during his PhD course at the University of Illinois at Urbana-Champaign (UIUC). This flexible GaN LED biosensor utilized a similar protocol to transfer thin GaN LED films onto flexible substrates, followed by a biocompatible packaging process; the system’s overall potential for use in implantable biomedical applications was demonstrated.
Professor John Roger (Department of Materials Science and Engineering, UIUC) said,
“Bio-integrated LEDs represent an exciting, new technology with strong potential to address important challenges in human health. This present work represents a very nice contribution to this emerging field.”
This paper was published in the online issue of Nano Energy Elsevier Journal (Editor, Prof. Zhong Lin Wang) dated September 16, 2011.
Flexible GaN LED produces blue light.
2011.09.20 View 11797 -
Professor Lee Sang Yeop Nominated the Chairman of Emerging Technologies Global Agenda Council of the World Economic Forum
Professor Lee Sang Yeop, Dean of College Life Science & Bioengineering, was appointed as the chairman of the Emerging Technologies Global Agenda Council of the World Economic Forum.
He will be in office till the 31st of August 2012, exactly 1 year from the date of his appointment.
The World Economic Forum (WEF) is a ‘think tank’ consisting of world leaders in various fields like economics, politics, and policies and has created the ‘Global Agenda Council’ to solve the problems mankind faces in achieving environmentally sustainable growth and suggest a collective vision and strategy.
The committee to be chaired by Professor Lee (Emerging Technologies Global Agenda Council) will discuss the direction in which the fields of biological engineering, nanotechnology, and IT (information technology) should develop and discuss the possible impact these fields will have on the society.
Professor Lee commented that, “I am extremely happy to be appointed as the chair of the Emerging Technologies Global Agenda Council at the World Economic Forum which is a gathering of world class leaders” and that “it is a great opportunity to spread Korea’s success and lessons in the advancement of science and technology.”
Professor Lee is the creator of the field of system metabolism engineering and is making great strides in manipulating the microorganism’s metabolic pathways on a systems scale to make changing chemicals derived from oil into eco-friendly and bio-based products.
2011.09.20 View 9742 -
Using Light to Deliver Drugs to the Brain
The cerebral blood vessels have a unique blood-brain barrier. Using this unique structure, Professor Choi Chul Hee (Department of Bio-Brain Engineering) developed a technique to deliver drugs safely to the brain using lasers to alter the diffusivity of the blood-brain barrier.
The blood-brain barrier allows the entry of only those drugs related to metabolic functions which made the entry of other drugs difficult.
Due to this property it was difficult to administer the drug to a patient and have it affect the patient. Therefore the question was is it possible to maintain the effectiveness of the drug and allow it to pass through the barrier?
The conventional method was to actually alter the structure of the drug or drill of small hole in the head and administering the drug directly, but these methods proved to be high risk and expensive.
Professor Choi’s team used an ultra-short frequency laser beam on the barrier for 1/1000th of a second on the barrier to temporarily inhibit its function thereby allowing the drug to enter the brain safely.
2011.06.20 View 9470
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Biomimetic Carbon Nanotube Fiber Synthesis Technology Developed
The byssus of the mussel allows it to live in harsh conditions where it is constantly battered by crashing waves by allowing the mussel to latch onto the seaside rocks. This particular characteristic of the mussel is due to the unique structure and high adhesiveness of the mussel’s byssus.
KAIST’s Professor Hong Soon Hyung (Department of Material Science and Engineering) and Professor Lee Hae Shin (Department of Chemistry) and the late Professor Park Tae Kwan (Department of Bio Engineering) were able to reproduce the mussel’s byssus using carbon nanotubes.
The carbon nanotube, since its discovery in 1991, was regarded as the next generation material due to its electrical, thermal, and mechanical properties. However due to its short length of several nanometers, its industrial use was limited.
The KAIST research team referred to the structure of the byssus of the mussel to solve this problem.
The byssus is composed of collagen fibers and Mefp-1 protein which are in a cross-linking structure. The Mefp-1 protein has catecholamine that allows it to bind strongly with the collagen fiber.
In the artificial structure, the carbon nanotube took on the role of the collagen fibers and the macromolecular adhesive took on the role of the catecholamine. The result was a fiber that was ultra-light and ultra-strong.
The results of the experiment were published in the Advanced Materials magazine and is patent registered both domestically and internationally.
2011.06.20 View 13104