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Distinguished Professor Lee Sang Yeop Appointed as Fellow of the American Institute of Chemical Engineers
Professor Lee Sang Yeop (Dean of the Department of Biological Sciences) has become the first Korea Scientist to be appointed as the Fellow of the American Institute of Chemical Engineers.
The American Institute of Chemical Engineers was founded in 1908 and boasts a 100 year history. It is composed of 43,000 members over 90 countries and is the largest international Academic Institute in the field of Chemical Engineering.
The Institute appoints Fellows after a rigorous procedure of recommendation and evaluation and Professor Lee is the first Korean to become a Fellow.
Professor Lee’s expertise is the field of Metabolic Engineering and successfully applied the system design method and optimization strategy of chemical engineering to biological systems thereby developing numerous core technologies for the biology based chemical industries.
Professor Lee is the founder of the System Metabolic Engineering and enabled the medical application of microorganisms by manipulating the metabolic pathways on a systems level in addition to making great progress in synthesizing various oil originated chemical materials using biology based, environmentally friends methods.
Professor Lee received the Marvin J. Johnson Award, Charles Thom Award, and has been appointed by the first Chairman of the Biotech Global Agenda Counsel of the World Economic Forum.
2012.09.22 View 8301 -
KAIST Alumni Association Hosts 1st Annual Mentoring Concert
KAIST Alums begin the management of a mentoring program for the benefit of worrying KAIST students.
President of KAIST Alumni Association will host on the 22nd of September the 1st Annual Mentoring Concert from 2pm to 8pm.
The Mentoring Concert was hosted in response to the Student Government Survey that enquired to the students of KAIST the type of help they’d like from Alumni.
The Alumni Association expanded its Goodwill Café program into the Mentoring Concert in order to improve the connection between the students and the alumni.
The Concert is composed of eight sessions (Academia, Industry, Government Institute, Consulting, Finance, Venture I, Venture II) and will involve 40 mentors and 400 mentees.
Each session will be attended by 5 mentors and 50 mentees and each mentor will give a ten minute presentation on the value of life, work experience, and their catalysis for choice of vocation.
KAIST Alumni Association stated that the Online Mentor System is under construction which will allow KAIST students to directly email mentors.
2012.09.22 View 6080
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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers.
*Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes.
Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions).
Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease.
Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease.
Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases.
However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself.
Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases.
The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases.
It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems.
The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30 View 11725
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Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11683
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10 Technolgies to Change the World in 2012: The Future Technology Global Agenda Council
The Future Technology Global Agenda Council which is under the World Economy Forum and which KAIST’s biochemical engineering department’s Prof. Sang Yeob Lee is the head of, chose the 10 new technologies that will change the world in year 2012.
The ten technologies include: IT, synthetic biology and metabolic engineering, Green Revolution 2.0, material construction nanotechnology, systematic biology and the simulation technology of biological systems, the technology to use CO2 as a natural resource, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology.
The technologies were chosen on the basis of the opinions various science, industry, and government specialists and is deemed to have high potential to change the world in the near future.
The Future Technology Global Agenda Council will choose ten new technologies yearly starting this year in order to solve the problems the world now faces.
The informatics systems that was ranked 1st place, sifts only the data necessary for decision making out of the overflowing amount of data. Much interest has been spurred at the Davos forum.
The synthetic biology and metabolic engineering chosen is expected to play an important role in creating new medicines and producing chemical substances and materials from reusable resources.
Biomass has also been chosen as one of the top ten most important technologies as it was seen to be necessary to lead the second Green Revolution in order to stably provide food for the increasing population and to create bio refineries.
Nanomaterials structured at the molecular level are expected to help us solve problems regarding energy, food, and resources.
Systematic biology and computer modeling is gaining importance in availing humans to construct efficient remedies, materials, and processes while causing minimum effects on the environment, resource reserves, and other people.
The technology to convert CO2, which is considered a problem all over the world, into a useful resource is also gaining the spotlight
Together with such technologies, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology are also considered the top ten technologies to change the world.
Prof. Lee said, “Many new discoveries are being made due to the accelerating rate of technological advancements. Many of the technologies that the council has found are sustainable and important for the construction of our future.”
2012.04.04 View 10265
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KAIST to Support R&D Plans of Mid-Small Sized Enterprises
KAIST signed a MOU for the ‘Support for R&D Plans for Mid-Small Sized Firms’ with the Small and Medium Business Conference and Korea South-East Power Co. Ltd.
KAIST and Korea South-East Power Co. Ltd. will now be improving their cooperation on supporting R&D plans to help the technology development and commercialization for Small and Medium Businesses.
Korea South-East Power Co. Ltd. will now select 20 best qualified firms out of its 300 cooperating firms and suggest them as candidates to KAIST Business membership System.
The suggested firms will be given: ▲Strategy R&D Planning ▲Consult Difficult Technology ▲Provide Information on Research Labs and Researchers among other various programs.
The firms participating in the KAIST Business membership System will be able to minimize risk and increase its possibility for success on Development Technology.
KAIST Business membership System is a program provided to firms for a membership fee, in order to create technological innovation and strengthen cooperation between university and industry.
2012.01.31 View 8397
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Professor Lee Jae Kyu : Appointed Fellow at Association of Information Systems
Professor Lee Jae Kyu of the Graduate School of Information Media Management was made Fellow of the Association of Information Systems.
Professor Less was the Chief Editor of Electronic Commerce Research and Applications, Chairman of Asia Pacific Information System Symposium, and Chairman of Korea Academy of Management Information, in addition to Chairman of the Academy of Korea Intelligence Information System.
The ‘Electronic Commerce’ co-written by Professor Lee is being used as primary MBA textbook in many universities around the world.
Homepage : http://www.business.kaist.ac.kr/faculty/jklee/
2012.01.31 View 8473
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KAIST's efforts begin to become the first Korean university establishing a "strategic technology management system."
KAIST completed the signing of business agreement with the Korea Strategic Trade Institute to establish a strategic technology management system on the 22nd of September.
The agreement between KAIST and Korea Strategic Trade Institute (under the Ministry of Knowledge Economy) encompasses 1) the establishment of processes for strategic technology management on campus, 2) development and accommodation of management system on par with major countries, and 3) protection and management through continued education and promotion.
Strategic technology management is necessary to prevent the illegal distribution of technologies developed in Korea to those countries and organizations of concern. The need for the management system arose due to the fact that technology transfer has become venerable to illegal export of strategic technologies.
The agreement between the two parties offer protection to KAIST when exporting strategic technologies as it necessitates the permission of the government prior to the technology transfer.
2011.09.27 View 7718 -
A frugal couple donates life savings of '35billion Korean Won' to KAIST.
Chairman Kim Byoung Ho and Mrs. Kim Sang Yeol have been the center of attention with various news articles and columns detailing their generous donation of real estate to KAIST, which amounted to 35billion Korean Won in value in total. Korean Broadcasting System (KBS) broadcasted a story on Chairman Byoung Ho and Mrs. Kim Sang Yeol on the 22nd of September. The broadcast link: http://news.kbs.co.kr/society/2011/09/22/2360159.html
Yahoo News also posted their donation on September 21, 2011. News link: http://ph.news.yahoo.com/frugal-woman-donates-4-3m-science-041003479.html
2011.09.27 View 8752 -
Bicycle Sharing System "Ta-Shu" Arrives at KAIST.
KAIST has begun providing a bike rental service, called “Ta-Shu,” to its students. This bicycle sharing system, implemented in tandem with the local city government, has been in service since the 7th of September and will allow KAIST students to rent bicycles for travel within campus and even to other parts of the city, Daejeon.
The ‘University Pubic-Bicycle Rental System’ is a program in which numbers of bicycles are made available for shared use by students. Initiated by the Ministry of Public Administration and Security, the university expects that more students will use bicycles as part of their daily mobility means through this system.
2011.09.22 View 7885 -
Future of Petrochemical Industry: The Age of Bio-Refineries
The concept of bio-refinery is based on using biomass from seaweeds and non-edible plant sources to produce various materials.
Bio-refineries has been looked into with increasing interest in modern times due to the advent of global warming (and the subsequent changes in the atmosphere) and the exhaustion of natural resources.
However past 20 years of research in metabolic engineering had a crucial limitation; the need to improve the efficiency of the microorganisms that actually go about converting biomass into biochemical materials.
In order to compensate for the inefficiency, Professor Lee Sang Yeop combined systems biology, composite biology, evolutionary engineering to form ‘systems metabolic engineering’.
This allows combining various data to explain the organism’s state in a multi-dimensional scope and respond accordingly by controlling the metabolism.
The result of the experiment is set as the cover dissertation of ‘Trends in Biotechnology’ magazine’s August edition.
2011.07.28 View 10771
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Professor Hwang Kyu Young Receives Outstanding Contributions Award from DASFAA
Professor Hwang Kyu Young received the 2011 Outstanding Contributions Award from the International Conference on Database Systems for Advanced Applications (DASFAA).
Professor Hwang was the Chairman, Vice Chairman, Executive, etc. of the DASFAA Steering Committee for the past 12 years and has been leading the development in the field of database in the Asia/Pacific Region. He was also the editor in chief of The VLDB Journal which is the leading magazine in the field of database and the member of ACM SIGMOD Jim Gray Dissertation Award Committee, VLDB 10-year Best Paper Award Committee, and IEEE ICDE Influential Paper Awards Committee. He receives the Outstanding Contributions Award for ensuring high standards in world database research.
2011.05.31 View 8612