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Simultaneous Analysis of 21 Chemical Reactions... AI to Transform New Drug Development
< Photo 1. (From left) Professor Hyunwoo Kim and students Donghun Kim and Gyeongseon Choi in the Integrated M.S./Ph.D. program of the Department of Chemistry >
Thalidomide, a drug once used to alleviate morning sickness in pregnant women, exhibits distinct properties due to its optical isomers* in the body: one isomer has a sedative effect, while the other causes severe side effects like birth defects. As this example illustrates, precise organic synthesis techniques, which selectively synthesize only the desired optical isomer, are crucial in new drug development. Overcoming the traditional methods that struggled with simultaneously analyzing multiple reactants, our research team has developed the world's first technology to precisely analyze 21 types of reactants simultaneously. This breakthrough is expected to make a significant contribution to new drug development utilizing AI and robots.
*Optical Isomers: A pair of molecules with the same chemical formula that are mirror images of each other and cannot be superimposed due to their asymmetric structure. This is analogous to a left and right hand, which are similar in form but cannot be perfectly overlaid.
KAIST's Professor Hyunwoo Kim's research team in the Department of Chemistry announced on the 16th that they have developed an innovative optical isomer analysis technology suitable for the era of AI-driven autonomous synthesis*. This research is the world's first technology to precisely analyze asymmetric catalytic reactions involving multiple reactants simultaneously using high-resolution fluorine nuclear magnetic resonance spectroscopy (19F NMR). It is expected to make groundbreaking contributions to various fields, including new drug development and catalyst optimization.
*AI-driven Autonomous Synthesis: An advanced technology that automates and optimizes chemical substance synthesis processes using artificial intelligence (AI). It is gaining attention as a core element for realizing automated and intelligent research environments in future laboratories. AI predicts and adjusts experimental conditions, interprets results, and designs subsequent experiments independently, minimizing human intervention in repetitive experiments and significantly increasing research efficiency and innovativeness.
Currently, while autonomous synthesis systems can automate everything from reaction design to execution, reaction analysis still relies on individual processing using traditional equipment. This leads to slower speeds and bottlenecks, making it unsuitable for high-speed repetitive experiments.
Furthermore, multi-substrate simultaneous screening techniques proposed in the 1990s garnered attention as a strategy to maximize reaction analysis efficiency. However, limitations of existing chromatography-based analysis methods restricted the number of applicable substrates. In asymmetric synthesis reactions, which selectively synthesize only the desired optical isomer, simultaneously analyzing more than 10 types of substrates was nearly impossible.
< Figure 1. Conventional organic reaction evaluation methods follow a process of deriving optimal reaction conditions using a single substrate, then expanding the substrate scope one by one under those conditions, leaving potential reaction areas unexplored. To overcome this, high-throughput screening is introduced to broadly explore catalyst reactivity for various substrates. When combined with multi-substrate screening, this approach allows for a much broader and more systematic understanding of reaction scope and trends. >
To overcome these limitations, the research team developed a 19F NMR-based multi-substrate simultaneous screening technology. This method involves performing asymmetric catalytic reactions with multiple reactants in a single reaction vessel, introducing a fluorine functional group into the products, and then applying their self-developed chiral cobalt reagent to clearly quantify all optical isomers using 19F NMR.
Utilizing the excellent resolution and sensitivity of 19F NMR, the research team successfully performed asymmetric synthesis reactions of 21 substrates simultaneously in a single reaction vessel and quantitatively measured the product yield and optical isomer ratio without any separate purification steps.
Professor Hyunwoo Kim stated, "While anyone can perform asymmetric synthesis reactions with multiple substrates in one reactor, accurately analyzing all the products has been a challenging problem to solve until now. We expect that achieving world-class multi-substrate screening analysis technology will greatly contribute to enhancing the analytical capabilities of AI-driven autonomous synthesis platforms."
< Figure 2. A method for analyzing multi-substrate asymmetric catalytic reactions, where different substrates react simultaneously in a single reactor, using fluorine nuclear magnetic resonance has been implemented. By utilizing the characteristics of fluorine nuclear magnetic resonance, which has a clean background signal and a wide chemical shift range, the reactivity of each substrate can be quantitatively analyzed. It is also shown that the optical activity of all reactants can be simultaneously measured using a cobalt metal complex. >
He further added, "This research provides a technology that can rapidly verify the efficiency and selectivity of asymmetric catalytic reactions essential for new drug development, and it is expected to be utilized as a core analytical tool for AI-driven autonomous research."
< Figure 3. It can be seen that in a multi-substrate reductive amination reaction using a total of 21 substrates, the yield and optical activity of the reactants according to the catalyst system were simultaneously measured using a fluorine nuclear magnetic resonance-based analysis platform. The yield of each reactant is indicated by color saturation, and the optical activity by numbers. >
Donghun Kim (first author, Integrated M.S./Ph.D. program) and Gyeongseon Choi (second author, Integrated M.S./Ph.D. program) from the KAIST Department of Chemistry participated in this research. The study was published online in the Journal of the American Chemical Society on May 27, 2025.※ Paper Title: One-pot Multisubstrate Screening for Asymmetric Catalysis Enabled by 19F NMR-based Simultaneous Chiral Analysis※ DOI: 10.1021/jacs.5c03446
This research was supported by the National Research Foundation of Korea's Mid-Career Researcher Program, the Asymmetric Catalytic Reaction Design Center, and the KAIST KC30 Project.
< Figure 4. Conceptual diagram of performing multi-substrate screening reactions and utilizing fluorine nuclear magnetic resonance spectroscopy. >
2025.06.16 View 247 -
KAIST Predicts Diseases by Early Detection of Aging Signals in Liver Tissue
- KAIST-KRIBB Develops ‘FiNi-seq’ Technology to Capture Characteristics of Fibrotic Microenvironments Accumulated in Liver Tissue and Dynamic Changes of Early Aging Cells
- Elucidation of the Spatial Ecosystem of Aged Liver Tissue, where Reprogramming of Senescent Cells and Immune Exhaustion Progresses, at the Single-Cell Genome and Epigenome Levels
< (From left) Professor Jong-Eun Park of KAIST Graduate School of Medical Science and Engineering (GSMSE), Dr. Chuna Kim of KRIBB, Dr. Kwon Yong Tak of KAIST GSMSE, Ph.D. Candidate Juyeon Kim of KRIBB, Ph.D. Candidate Myungsun Park of KAIST GSMSE >
Aging and chronic diseases involve the gradual accumulation of subtle tissue changes over a long period. Therefore, there are still limitations in quantitatively understanding these changes within organs and linking them to early signs of disease onset. In response, Korean researchers have successfully developed a platform technology that accurately captures localized changes that first occur within tissue, significantly aiding in faster disease discovery and prediction, and in setting personalized treatment targets.
KAIST (President Kwang Hyung Lee) announced on June 12th that a joint research team led by Professor Jong-Eun Park of the Graduate School of Medical Science and Engineering at KAIST and Dr. Chuna Kim of the Aging Convergence Research Center at the Korea Research Institute of Bioscience and Biotechnology (KRIBB, President Seok-Yoon Kwon) has developed ‘FiNi-seq (Fibrotic Niche enrichment sequencing)’ technology. This technology captures fibrotic microenvironments locally occurring in aged liver tissue and enables precise analysis at the single-cell transcriptome level*.
*Single-cell transcriptome analysis: A method to measure how actively each cell uses which genes, allowing identification and function of individual diseased cells.
The researchers developed a method to selectively enrich early aging microenvironments where regeneration is delayed and fibrosis accumulates, by physically selecting regions with high tissue degradation resistance in aged liver tissue.
In this process, high-resolution identification of fibrosis-related endothelial cells, fibroblasts interacting with the immune system, and immune-exhausted cells such as PD-1 highly expressing CD8 T cells, which were difficult to capture with existing single-cell analysis technologies, was possible.
In particular, the research team confirmed through ‘FiNi-seq’ technology that specific cells observed in fibrotic areas within aged liver tissue secondarily age the surrounding environment through secreted factors, and that this leads to the expansion of the aged environment.
Furthermore, they also elucidated the mechanism by which endothelial cells lose their tissue-specific identity and induce innate immune responses, promoting immune cell infiltration. Through spatial transcriptome analysis, the spatial distribution of fibroblasts interacting with immune cells was quantified, revealing their involvement in tissue regeneration, induction of inflammatory responses, and progression to chronic fibrosis.
The research team performed integrated analysis of multi-omics\* data to obtain transcriptome and epigenome information, precisely interpreting the microenvironment of aged liver tissue and its spatial heterogeneity, and confirming how these changes are connected to the intrahepatic vascular structure.
*Multi-omics: An integrated analysis method for various biological information within an organism, such as genes, proteins, metabolites, and cell information.
The newly developed ‘FiNi-seq’ technology is expected to be a useful platform for high-resolution capture of pathophysiological signals in most chronic liver diseases, including the aging process that causes fibrosis.
< Figure 1. Isolation of fibrotic regions from aged liver tissue, followed by single-cell transcriptome analysis and validation in a fibrosis model. >
The first author, Dr. Kwon Yong Tak of KAIST Graduate School of Medical Science and Engineering (GSMSE), a hepatologist at Seoul St. Mary's Hospital, designed this study to lay the groundwork for early diagnosis and treatment of fibrosis progression, the most important clinical prognostic indicator in chronic liver disease, while pursuing his Ph.D. at KAIST KAIST GSMSE with support from the physician-scientist training program. Co-first author Myungsun Park, a Ph.D. candidate at KAIST KAIST GSMSE, was responsible for the technical implementation of FiNi-seq technology, and Juyeon Kim, a Ph.D. candidate at KRIBB's Aging Convergence Research Center, was responsible for imaging analysis of aged tissue, playing a key role in the research.
Dr. Chuna Kim of KRIBB stated, “Through this study, we were able to precisely elucidate the cellular composition and spatial characteristics of the fibrotic microenvironment observed in aged liver tissue at the single-cell level.”
< Figure 2. Spatially defined stepwise progression patterns of aging-related regions within the liver and identification of regulatory factors inducing them. >
Professor Jong-Eun Park of the Graduate School of Medical Science and Engineering said, “As an analytical technology that can capture subtle changes occurring in the early stages of aging and chronic diseases, it is expected to play a significant role in finding effective treatment targets in the future. Also, we plan to expand this research to chronic diseases in other organs such as the lungs and kidneys, as well as various liver disease models.”
This research was published in the international journal ‘Nature Aging’ on May 5, 2025, with Dr. Kwon Yong Tak of KAIST KAIST GSMSE, Ph.D. Candidate Juyeon Kim of KRIBB, and Ph.D. Candidate Myungsun Park of KAIST as co-first authors.
*Paper Title: Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver
*DOI: https://doi.org/10.1038/s43587-025-00857-7
This research was supported by several domestic institutions, including the National Research Foundation of Korea, the Korea Health Industry Development Institute (KHIDI), the Korea Research Institute of Bioscience and Biotechnology (KRIBB), KIST, POSCO Science Fellowship, and the Convergence Medical Scientist Training Program.
2025.06.12 View 389 -
A 10-Month Journey of Tiny Flaps Completed: A Special Family Returns to KAIST Duck Pond
On the morning of June 9, 2025, gentle activity stirred early around the KAIST campus duck pond. It was the day a special family of ducks—and two goslings—were to be released back into the pond after spending a month in a temporary shelter. One by one, the ducklings cautiously emerged from their box, waddling toward the water's edge and scanning their surroundings, followed closely by their mother.
< The landscape manager from the KAIST Facilities Team releases the ducks and goslings. >
The mother duck, once a rescued loner who couldn’t integrate with the flock, returned triumphantly as the head of a new family—caring for both ducklings and goslings. Students and faculty looked on quietly, welcoming them back and reflecting on their remarkable 10-month journey.
The story began in July 2024, as a student filed a report of spotting two ducklings wandering near the pond without a mother. Based on their soft down, flat beaks, and lack of fear around humans, it was presumed they had been abandoned. Professor Won Do Heo of the Department of Biological Sciences—affectionately known as the “Goose Dad”—and the KAIST Facilities Team quickly stepped in to rescue them. After about a month of care, the ducklings were released back into the pond.
< On June 9, the day of the release, KAIST President Kwang-Hyung Lee (left), the former “Goose Dad,” and Professor Won Do Heo (right), the current “Goose Dad,” watched the flock as they freely wobbled about. >
At first, the ducklings seemed to adapt, but they started distancing themselves from the established goose flock. One eventually disappeared, and the remaining duckling was found injured by the pond during winter. Although KAIST typically avoids making human interference in the natural ecosystem, an exception was made to save the young duck’s life. It was put under the care of Professor Heo and the Facilities Team to regain its health within a month.
In the spring, the healed duck began laying eggs. Professor Heo supported the process by adjusting its diet, avoiding further intervention. On Children’s Day, May 5, the duck’s eggs hatched. The once-isolated duck had become a mother. Ten days later, on May 15, four goslings also hatched from the resident goose flock. With new life flourishing, the pond was more vibrant than ever.
< Rescued baby goslings near the pond, alongside the duck family that took them in. The mother duck—once a vulnerable duckling herself—had grown strong enough to care for others in need. >
But just days later, the mother goose disappeared, and two goslings—still unable to swim—were found shivering by the pond. Dahyeon Byeon, a student from Seoul National University who came for a visit on that day, reported this upon sighting, prompting another rescue. The vulnerable goslings were brought to the shelter to stay with the duck family.
Initially, the interspecies cohabitation was uneasy. But the mother duck did not reject the goslings. Slowly, they began to eat and sleep together, forming a new kind of family. After a month, they were released together into the pond—and to everyone’s surprise, the existing goose flock accepted both the goslings and the duck family.
< A peaceful moment for the duck family. The baby goslings naturally followed the mother duck. >
It took ten months for this family to return. From abandonment and injury to healing, birth, and unexpected bonds, this was more than a story of survival. It was a journey of transformation. The duck family’s ten-month saga is a quiet miracle—written in small moments of crisis, care, and connection—and a lasting memory on the KAIST campus.
< The resident goose flock at KAIST’s pond naturally accepted the returning duck and goslings as part of their group. >
2025.06.10 View 591 -
Life Springs at KAIST: A Tale of Two Special Campus Families
A Gift of Life on Teachers' Day: Baby Geese Born at KAIST Pond
On Teachers' Day, a meaningful miracle of life arrived at the KAIST campus. A pair of geese gave birth to two goslings by the duck pond.
< On Teachers' Day, a pair of geese and their goslings leisurely swim in the pond. >
The baby goslings, covered in yellow down, began exploring the pond's edge, scurrying about, while their aunt geese steadfastly stood by. Their curious glances, watchful gazes, playful hops on waterside rocks, and the procession of babies swimming behind their parents in the water melted the hearts of onlookers.
< As night falls on the duck pond, the goose family gathers among the reeds. >
This special new life, born on Teachers' Day, seems to symbolize the day's meaning of "care" and "growth." This wondrous scene of life brought warm comfort and joy to KAIST members, adding the inspiration of nature to a campus that is a space for research and learning.
< Under the protection of the adult geese, the goslings take their first steps, exploring the pond's grassy areas and rocks. >
This adorable family is already roaming the area leisurely, like the pond's owners. With the joy of life added to the spring-filled pond, warm smiles are spreading across the KAIST campus.
< The geese look around, surveying their surroundings, while caring for their goslings. >
The pond has now become a small but special haven for students and staff. This goose family, arriving on Teachers' Day, quietly reminds us of the meaning of care and learning conveyed by nature.
< The goose family shows care and growth, and warm moments together are anticipated. >
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On Children's Day 2025, a Duck Becomes a Mother
In July 2024, a special guest arrived at the KAIST campus. With soft yellow down, waddling gait, and a flat beak, it was undeniably a baby duck. However, for some reason, its mother was nowhere to be seen. Given that it wasn't afraid of people and followed them well, it was clear that someone had abandoned the duck.
Fortunately, the baby duck was safely rescued thanks to prompt reporting by students.
< Two ducks found on a corner of campus, immediately after their rescue in summer 2024. >
The ducks, newly integrated into KAIST, seemed to adapt relatively peacefully to campus life. As new additions, they couldn't blend in with the existing goose flock that had settled on campus, but the geese didn't ostracize them either. Perhaps because they were awkward neighbors, there was hope that the ducks would soon join the existing goose flock.
< Following their rescue based on a student's report in summer 2024, the ducks adapted to campus life under the protection of the campus facility team and Professor Won Do Heo. >
Professor Won Do Heo of the Department of Biological Sciences, widely known as "Goose Dad," stepped forward to protect them along with the KAIST facility team. Professor Heo is well-known for consistently observing and protecting the campus geese and ducks, which are practically symbols of KAIST. Thanks to the care of the staff and Professor Heo, the two ducks were safely released back onto campus approximately one month after their rescue.
< A moment on campus: Before winter, the ducks lived separately from the goose flock, maintaining a certain distance. While there were no conflicts, they rarely socialized. >
However, as winter passed, sad news arrived. One duck went missing, and the remaining one was found injured by the pond. While the policy of the facility team and Professor Heo was to minimize intervention to allow campus animals to maintain their natural state, saving the injured duck was the top priority. After being isolated again for a month of recovery, the duck fully recovered and was able to greet spring under the sun.
< The mother duck left alone in winter: One went missing, and the remaining one was found injured. After indoor isolation and recovery, she was released back onto campus in the spring. >
As spring, the ducks' breeding season, began, Professor Heo decided to offer a little more help. When signs of egg-laying appeared, he consistently provided "special meals for pregnant mothers" throughout March. On the morning of May 5th, Children's Day, 28 days after the mother duck began incubating her eggs with the care and attention of KAIST members, new life finally hatched. It was a precious outcome achieved solely by the duck that had survived abandonment and injury, with no special protection other than food.
The duck, having overcome hardship and injury to stand alone, has now formed a new family. Although there is still some distance from the existing goose flock, it is expected that they will naturally find their place in the campus ecosystem, as KAIST's geese are not aggressive or exclusive. The KAIST goose flock already has experience protecting and raising five ducklings.
< A new beginning by the pond on Children's Day: On the morning of May 5th, the 28th day of incubation, four ducklings hatched by the pond. This was a natural hatching, achieved without protective equipment. >
A single duck brought a special spring to the KAIST campus on Children's Day. The outcome achieved by that small life, leading to the birth of a new family, also symbolizes the harmonious coexistence of people and animals on the KAIST campus. The careful intervention of KAIST members, providing only the necessary assistance from rescue to hatching, makes us reconsider what "desirable coexistence between animals and people" truly means.
2025.05.21 View 1496 -
Formosa Group of Taiwan to Establish Bio R&D Center at KAIST Investing 12.5 M USD
KAIST (President Kwang-Hyung Lee) announced on February 17th that it signed an agreement for cooperation in the bio-medical field with Formosa Group, one of the three largest companies in Taiwan.
< Formosa Group Chairman Sandy Wang and KAIST President Kwang-Hyung Lee at the signing ceremony >
Formosa Group Executive Committee member and Chairman Sandy Wang, who leads the group's bio and eco-friendly energy sectors, decided to establish a bio-medical research center within KAIST and invest approximately KRW 18 billion or more over 5 years. In addition, to commercialize the research results, KAIST and Formosa Group will establish a joint venture in Korea with KAIST Holdings, a KAIST-funded company.
The cooperation between the two organizations began in early 2023 when KAIST signed a comprehensive exchange and cooperation agreement (MOU) with Ming Chi University of Science and Technology (明志科技大學), Chang Gung University (長庚大學), and Chang Gung Memorial Hospital (長庚記念醫院), which are established and supported by Formosa Group. Afterwards, Chairman Sandy Wang visited KAIST in May 2024 and signed a more specific business agreement (MOA).
KAIST Holdings is a holding company established by KAIST, a government-funded organization, to attract investment and conduct business, and will pursue the establishment of a joint venture with a 50:50 equity structure in cooperation with Formosa Group. KAIST Holdings will invest KAIST’s intellectual property rights, and Formosa Group will invest a corresponding amount of funds.
The KAIST-Formosa joint venture will provide research funds to the KAIST-Formosa Bio-Medical Research Center to be established in the future, secure the right to implement the intellectual property rights generated, and promote full-scale business.
The KAIST-Formosa Bio-Medical Research Center will establish a ‘brain organoid bank’ created by obtaining tissues from hundreds of patients with degenerative brain diseases, thereby securing high-dimensional data that will reveal the fundamental causes of aging and disease. It is expected that KAIST’s world-class artificial intelligence technology will analyze large-scale patient data to find the causes of aging and disease.
Through this business, it is expected that by 2030, five years from now, it will discover more than 10 types of intractable brain disease treatments and expand to more than 20 businesses, including human cell-centered diagnostics and preclinical businesses, and secure infrastructure and intellectual property rights that can create value worth approximately KRW 250 billion.
The Chang Gung Memorial Hospital in Taiwan has 10,000 beds and handles 35,000 patients per day, and systematically accumulates patient tissue and clinical data. Chang Gung Memorial Hospital will differentiate the tissues of patients with degenerative brain diseases and send them to the KAIST-Formosa Bio-Medical Research Center, which will then produce brain organoids to be used for disease research and new drug development. This will allow the world’s largest patient tissue data bank to be established.
Dean Daesoo Kim of the College of Life Science and Bioengineering at KAIST said, “This collaboration between KAIST and Formosa Group is a new research collaboration model that goes beyond joint research to establish a joint venture and global commercialization of developed technologies, and it is significant in that it can serve as an opportunity to promote biomedical research and development.”
With this agreement, KAIST, which has been promoting the KAIST Advanced Regenerative Medicine Engineering Center in Osong K-Bio Square, has secured a practical global partner.
< Representatives of the Formosa Group and KAIST >
KAIST’s Senior Vice President for Planning and Budget, Professor Kyung-Soo Kim emphasized, “KAIST has made great efforts to secure an edge in state-of-the-art biomedical fields such as stem cells and gene editing technology, by attracting the world’s best experts and discovering global cooperation partners, and these results can ultimately be linked to the Osong K-Bio Square project.”
SVP Kim then predicted, “In particular, the practical cooperation with Taiwan’s best Formosa Chang Gung Memorial Hospital, which has abundant clinical experience in stem cell treatment, will be an important axis of KAIST’s bio innovation strategy.”
Formosa Chairman Sandy Wang emphasized that this investment and cooperation is built on trust in KAIST’s R&D capabilities and the passion of its researchers. And added that through this, the Formosa Group will practice corporate social responsibility and take an important first step together with KAIST to protect the welfare and health of humanity. She also went on the say that she expects to see the cooperation expanded to various fields such as mobility and semiconductors based on the successes begotten from the cooperation in the bio field.
KAIST President Kwang-Hyung Lee said, “I evaluate this agreement as one of the most important events that will spearhead KAIST into overseas biotechnology stages,” and added, “I expect that this cooperation will be an opportunity for Taiwan and Korea, both of which have IT industry-centered structures, to create new growth engines in the bio industry.” Meanwhile, Formosa Group is a company founded by Chairman Sandy Wang’s father, Chairman Yung-Ching Wang. It is the world’s No. 1 plastic PVC producer and is leading core industries of the Taiwanese economy, including semiconductors, steel, heavy industry, bio, and batteries. Chairman Yung-Ching Wang was respected by the Taiwanese people for his exemplary return of wealth to society under the belief that the companies and assets he founded “belong to the people.”
2025.02.17 View 3245 -
KAIST Research Team Develops Stretchable Microelectrodes Array for Organoid Signal Monitoring
< Photo 1. (From top left) Professor Hyunjoo J. Lee, Dr. Mi-Young Son, Dr. Mi-Ok Lee(In the front row from left) Doctoral student Kiup Kim, Doctoral student Youngsun Lee >
On January 14th, the KAIST research team led by Professor Hyunjoo J. Lee from the School of Electrical Engineering in collaboration with Dr. Mi-Young Son and Dr. Mi-Ok Lee at Korea Research Institute of Bioscience and Biotechnology (KRIBB) announced the development of a highly stretchable microelectrode array (sMEA) designed for non-invasive electrophysiological signal measurement of organoids.
Organoids* are highly promising models for human biology and are expected to replace many animal experiments. Their potential applications include disease modeling, drug screening, and personalized medicine as they closely mimic the structure and function of humans.
*Organoids: three-dimensional in vitro tissue models derived from human stem cells
Despite these advantages, existing organoid research has primarily focused on genetic analysis, with limited studies on organoid functionality. For effective drug evaluation and precise biological research, technology that preserves the three-dimensional structure of organoids while enabling real-time monitoring of their functions is needed. However, it’s challenging to provide non-invasive ways to evaluate the functionalities without incurring damage to the tissues. This challenge is particularly significant for electrophysiological signal measurement in cardiac and brain organoids since the sensor needs to be in direct contact with organoids of varying size and irregular shape. Achieving tight contact between electrodes and the external surface of the organoids without damaging the organoids has been a persistent challenge.
< Figure 1. Schematic image of highly stretchable MEA (sMEA) with protruding microelectrodes. >
The KAIST research team developed a highly stretchable microelectrode array with a unique serpentine structure that contacts the surface of organoids in a highly conformal fashion. They successfully demonstrated real-time measurement and analysis of electrophysiological signals from two types of electrogenic organoids (heart and brain). By employing a micro-electromechanical system (MEMS)-based process, the team fabricated the serpentine-structured microelectrode array and used an electrochemical deposition process to develop PEDOT:PSS-based protruding microelectrodes. These innovations demonstrated exceptional stretchability and close surface adherence to various organoid sizes. The protruding microelectrodes improved contact between organoids and the electrodes, ensuring stable and reliable electrophysiological signal measurements with high signal-to-noise ratios (SNR).
< Figure 2. Conceptual illustration, optical image, and fluorescence images of an organoid captured by the sMEA with protruding microelectrodes.>
Using this technology, the team successfully monitored and analyzed electrophysiological signals from cardiac spheroids of various sizes, revealing three-dimensional signal propagation patterns and identifying changes in signal characteristics according to size. They also measured electrophysiological signals in midbrain organoids, demonstrating the versatility of the technology. Additionally, they monitored signal modulations induced by various drugs, showcasing the potential of this technology for drug screening applications.
< Figure 3. SNR improvement effect by protruding PEDOT:PSS microelectrodes. >
Prof. Hyunjoo Jenny Lee stated, “By integrating MEMS technology and electrochemical deposition techniques, we successfully developed a stretchable microelectrode array adaptable to organoids of diverse sizes and shapes. The high practicality is a major advantage of this system since the fabrication is based on semiconductor fabrication with high volume production, reliability, and accuracy. This technology that enables in situ, real-time analysis of states and functionalities of organoids will be a game changer in high-through drug screening.”
This study led by Ph.D. candidate Kiup Kim from KAIST and Ph.D. candidate Youngsun Lee from KRIBB, with significant contributions from Dr. Kwang Bo Jung, was published online on December 15, 2024 in Advanced Materials (IF: 27.4).
< Figure 4. Drug screening using cardiac spheroids and midbrain organoids.>
This research was supported by a grant from 3D-TissueChip Based Drug Discovery Platform Technology Development Program (No. 20009209) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea), by the Commercialization Promotion Agency for R&D Outcomes (COMPA) funded by the Ministry of Science and ICT (MSIT) (RS-2024-00415902), by the K-Brain Project of the National Research Foundation (NRF) funded by the Korean government (MSIT) (RS-2023-00262568), by BK21 FOUR (Connected AI Education & Research Program for Industry and Society Innovation, KAIST EE, No. 4120200113769), and by Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (KGM4722432).
2025.01.14 View 3351 -
KAIST’s RAIBO2 becomes the World’s First Robo-dog to Successfully Complete a Full-course Marathon
KAIST's quadrupedal walking robot "RAIBO", which can run seamlessly on sandy beaches, has now evolved into "RAIBO2"and achieved the groundbreaking milestone by becomeing the world's first quadrupedal robot to successfully complete a full-course marathon in an official event.
< Photo 1. A group photo of RAIBO2 and the team after completing the full-course marathon >
KAIST (President Kwang Hyung Lee) announced on the 17th of November that Professor Je Min Hwangbo's research team of the Department of Mechanical Engineering participated in the 22nd Sangju Dried-Persimmon Marathon and completed the full-course race (42.195 km) with a time of 4 hours 19 minutes and 52 seconds.
< Photo 2. RAIBO2 after completing the full-course marathon with its official record presented on the photo wall >
The Sangju Dried Persimmon Marathon is known for its challenging course featuring two 50 m elevation climbs, each at the 14 km and 28 km marks, making it defficult for amateur runners. This made it an especially demanding challenge for the walking robot, as unexpected losses in efficiency could occur.
< Photo 3. RAIBO2 with the completion medal around its neck >
To prepare RAIBO2, Professor Hwangbo's team developed a walking controller using reinforcement learning algorithms within their proprietary simulation environment "RaiSim". This simulator allowed the team to simlate diverse terrains such as slopes, stairs, and icy roads to ensure stable walking performance.
In particular, RAIBO2's high torque transparency joint mechanism enable the robot to efficiently harvest energy on the downhill slopes to regain some of the energy used in climbing up steep hill.
In addition, the stability of the robot was greatly improved through the collaboration with RAION ROBOTICS Inc., a company founded by the researchers from Professor Hwangbo’s lab.
< Figure 1. Conceptual diagram of power flow employed by the quadrupedal robot >
< Figure 2. The process of leg posture change of RAIBO2 walking at the most efficient walking speed of 3 m/s. By reducing the ground contact speed of the feet, the collision energy loss was reduced, and by minimizing the slipperiness of the foot upon contact, the body's kinetic energy was maintained towards the direction of the movement. >
Due to the nature of walking, pedal robots must employ highly complex systems that can withstand periodic vibrations from the frequent impacts that occur upon contact with the ground surface. Immediately after development, high efficiency was already recorded in short-distance experiments in the laboratory at the beginning of the year, but the manufacturing technology of RAION ROBOTICS significantly bolstered RAIBO's performance in running safely for a prolonged time of more than 4 hours among random pack of people in an actual marathon.
Compared to previous studies on improving walking efficiency, where external parts or software could not be changed and only limited improvements were made in some areas, Professor Hwangbo’s research team cited the fact that they were able to comprehensively solve problems by developing all steps and parts in-house, including mechanism design, electrical design, software, and artificial intelligence, as a key factor in improving efficiency.
Following the development of RAIBO1, the research team developed RAIBO2 and optimized all aspects of the robot. In particular, the team integrated the motor driver circuitry directly into the robot to minimize actuator losses and increase the control bandwidth, greatly improving walking efficiency and stability.
< Photo 4. RAIBO2 running the full-course marathon along human participants >
Choongin Lee, a Ph.D. Student that co-first author of the studies on RAIBO, said, “Through the marathon project, we demonstrated that RAIBO2 has the walking performance to stably execute services such as delivery and patrol in urban environments with many people and random objects,” and “In follow-up research, we will add autonomous navigation functions to RAIBO and strive to achieve the world’s best walking performance in mountainous and disaster environments.”
< Photo 5. RAIBO2 and co-first authors of the related research at the Ph.D. program of the Department of Mechanical Engineering at KAIST. (From left) Choongin Lee, Donghoon Youm, and Jeongsoo Park >
This research was conducted with the support of Samsung Electronics Future Technology Promotion Center and RAION ROBOTICS Inc.
2024.11.17 View 7606 -
KAIST Researchers Suggest an Extraordinary Alternative to Petroleum-based PET - Bacteria!
< (From left) Dr. Cindy Pricilia, Ph.D. Candidate Cheon Woo Moon, Distinguished Professor Sang Yup Lee >
Currently, the world is suffering from environmental problems caused by plastic waste. The KAIST research team has succeeded in producing a microbial-based plastic that is biodegradable and can replace existing PET bottles, making it a hot topic.
Our university announced on the 7th of November that the research team of Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering has succeeded in developing a microbial strain that efficiently produces pseudoaromatic polyester monomer to replace polyethylene terephthalate (PET) using systems metabolic engineering.
Pseudoaromatic dicarboxylic acids have better physical properties and higher biodegradability than aromatic polyester (PET) when synthesized as polymers, and are attracting attention as an eco-friendly monomer* that can be synthesized into polymers. The production of pseudoaromatic dicarboxylic acids through chemical methods has the problems of low yield and selectivity, complex reaction conditions, and the generation of hazardous waste.
*Monomer: A material for making polymers, which is used to synthesize polymers by polymerizing monomers together
< Figure. Overview of pseudoaromatic dicarboxylic acid production using metabolically engineered C. glutamicum. >
To solve this problem, Professor Sang Yup Lee's research team used metabolic engineering to develop a microbial strain that efficiently produces five types of pseudoaromatic dicarboxylic acids, including 2-pyrone-4,6-dicarboxylic acid and four types of pyridine dicarboxylic acids (2,3-, 2,4-, 2,5-, 2,6-pyridine dicarboxylic acids), in Corynebacterium, a bacterium mainly used for amino acid production.
The research team used metabolic engineering techniques to build a platform microbial strain that enhances the metabolic flow of protocatechuic acid, which is used as a precursor for several pseudoaromatic dicarboxylic acids, and prevents the loss of precursors.
Based on this, the genetic manipulation target was discovered through transcriptome analysis, producing 76.17 g/L of 2-pyrone-4,6-dicarboxylic acid, and by newly discovering and constructing three types of pyridine dicarboxylic acid production metabolic pathways, successfully producing 2.79 g/L of 2,3-pyridine dicarboxylic acid, 0.49 g/L of 2,4-pyridine dicarboxylic acid, and 1.42 g/L of 2,5-pyridine dicarboxylic acid.
In addition, the research team confirmed the production of 15.01 g/L through the construction and reinforcement of the 2,6-pyridine dicarboxylic acid biosynthesis pathway, successfully producing a total of five similar aromatic dicarboxylic acids with high efficiency.
In conclusion, the team succeeded in producing 2,4-, 2,5-, and 2,6-pyridine dicarboxylic acids at the world's highest concentration. In particular, 2,4-, 2,5-pyridine dicarboxylic acid achieved production on the scale of g/L, which was previously produced in extremely small amounts (mg/L).
Based on this study, it is expected that it will be applied to various polyester production industrial processes, and it is also expected that it will be actively utilized in research on the production of similar aromatic polyesters.
Professor Sang Yup Lee, the corresponding author, said, “The significance lies in the fact that we have developed an eco-friendly technology that efficiently produces similar aromatic polyester monomers based on microorganisms,” and “This study will help the microorganism-based bio-monomer industry replace the petrochemical-based chemical industry in the future.”
The results of this study were published in the international academic journal, the Proceedings of the National Academy of Sciences of United States of America (PNAS) on October 30th.
※ Paper title: Metabolic engineering of Corynebacterium glutamicum for the production of pyrone and pyridine dicarboxylic acids
※ Author information: Jae Sung Cho (co-first author), Zi Wei Luo (co-first author), Cheon Woo Moon (co-first author), Cindy Prabowo (co-author), Sang Yup Lee (corresponding author) - a total of 5 people
This study was conducted with the support of the Development of Next-generation Biorefinery Platform Technologies for Leading Bio-based Chemicals Industry Project and the Development of Platform Technologies of Microbial Cell Factories for the Next-generation Biorefineries Project (Project leader: Professor Sang Yup Lee) from the National Research Foundation supported by the Ministry of Science and Technology and ICT of Korea.
2024.11.08 View 7996 -
Team KAIST Crowned Champion for their World’s Best Ironman, Winning their 2nd Consecutive Win at the Cyborg Olympics
< Group photo of our research team participating in the 3rd Cybathlon >
The Cybathlon is an international competition, which aims to help overcome disabilities through the use of robotics technology. KAIST researchers came in third, winning the bronze medal, at their 1st participation in 2016, won their first gold medal at the 2nd competition in 2020, and took back the gold medal at this year’s 3rd competition, successfully defending their champion title.
KAIST (President Kwang-Hyung Lee) announced on the 28th of October that the wearable robot ‘WalkON Suit F1’ developed by the joint research team of KAIST EXO-Lab, Move Lab, and Angel Robotics, led by Professor Kyoungchul Kong of the Department of Mechanical Engineering (Chairman of Angel Robotics), won gold medal in Cybathlon 2024 held on the 27th.
< Seunghwan Kim, the Paraplegic Pilot of Team KAIST, cheering after completing all the missions >
Cybathlon is an international competition first held in Switzerland that challenges teams to develop assistive technologies with the purpose of overcoming disabilities, and is also called the Cyborg Olympics. Right after each competition, the missions for the next competition are announced, and research teams from around the world research and develop the right assistive technology for next four years to accomplish the given mission.
Aside from the Exoskeleton Race, competitions in a total of eight disciplines are held, including Arm Prosthesis Race, Leg Prosthesis Race, and Wheelchair Race. A total of 71 teams from 26 countries participated in the 3rd Cybathlon event. Professor Kyoungchul Kong’s research team participated in the Exoskeleton Race, the same discipline they took part in the previous competition.
The Exoskeleton Race is the highlight of the event that can be called the core of the Cybathlon. In the prosthetic arm or leg events, disabled athletes wearing traditional assistive devices instead of powered devices often win depending more on the ability of the athletes rather than the technology behind the tools.
However, the exoskeleton event requires individuals with paraplegic disability to walk completely dependent on the robotic device to perform various missions, so the technical difficulty and the dependence on robotics technology is high.
In fact, many teams gave up on participating after seeing the missions for this competition, and more than half of the research teams declared withdrawal during the developmental process. In the end, only six teams from Korea, Thailands, Switzerland, Germany, and the Netherlands participated in the actual competition. Even the research team from the Swiss headquarters declared forfeiture midway as the competition date drew nearer.
< Cybathlon 2024 – Exoskeleton Race Mission Description >
The reason why many teams gave up in the exoskeleton discipline was because the difficulty of the missions was unusually high. Most research teams have the skills to make paraplegic athletes walk, but there were many other difficult tasks, such as making them walk without crutches or using both hands, while standing free on both legs on the exoskeleton, to cut a lump of sponge block, as in imitating food preparing process.
The reason why the difficulty of the missions increased like this is because Professor Kong's research team completed all the missions given to them too quickly in the last competition. In fact, in the last competition, there was even a question asked whether Kim Byeong-Uk (paraplegic) wearing the WalkON Suit F1 was really disabled.
Professor Kong's research team developed WalkON Suit F1 to successfully complete the missions. The number of motorized joints increased from six to twelve, and the output of the motor itself was more than doubled compared to the previous model that ran in the competition back in 2020. The 6-channel ground reaction force sensor on the foot measured the robot's balance 1,000 times per second to maintain balance. Cameras were installed to detect obstacles, and an AI board for implementation of AI neural network was also installed.
On top of the technologies required to complete the competition missions, a function was implemented that allows the users to wear the robot by themselves and dock on to it right from their wheelchair. In the process, all parts were domestically produced and all basic technologies were internalized. The outer design of the robot was done by Professor Hyunjoon Park of KAIST, and the harmony between people and robots was pursued.
In the end, the results of the competition were as expected. The only team that could successfully perform all of the mission tasks, which were originally designed to challenge Professor Kong's research team, was Professor Kong's team. They successfully completed missions such as moving by sidesteps between narrow chairs, moving boxes, walking freely unassisted by crutches, passing through a narrow door and closing it behind, and working on food preparation in the kitchen, recording 6 minutes and 41 seconds to complete all six tasks.
The Swiss and Thai teams that took 2nd and 3rd places were all given 10 minutes, but only were able to perform two missions, each earning twenty points. It was an unevenly matched race to begin with. The Cybathlon broadcast team was more surprised and interested in the performance of WalkON Suit F1 than in result of the race.
< Team KAIST’s Paraplegic Pilot Seunghwan Kim (left), and Professor Kyoungchul Kong (right) >
Researcher Jeongsu Park, the captain of Team KAIST, said, “We came into this competition thinking of it as a competition against ourselves to begin with and focused on showing the technological gap. Now, we are very happy and proud that our endeavors achieved such good result as well.” He added, “We plan to continue to showcase various functions of the WalkON Suit F1 that have not yet been publicly introduced.”
Researcher Seunghwan Kim, the paraplegic athlete of the team, said, “I am so touched that I was able to introduce the world’s best wearable robot technology of Korea with my own body.”
On a different note, Professor Kong’s research team has successfully commercialized wearable robots through Angel Robotics Co., Ltd. since the 2020 competition. In 2022, they began distributing “ANGEL LEGS M20,” the first wearable robot to be covered by health insurance, and as a result, Angel Robotics Co., Ltd. was successfully listed on KOSDAQ this March.
The various know-how and core technologies accumulated while preparing for this competition is to contribute to further development and propagation of wearable robots, provoking imagination to draw on the future of wearable robots and on how it may change our daily lives.
Final Match (Self-filmed): https://youtu.be/3ASAtvkiOhw
Final Match and Interview (Official Video): https://youtu.be/FSfxOTpDjSE
Final Match and Interview (Summary): https://youtu.be/Sb_vd5-3f_0
2024.10.28 View 8149 -
KAIST Professor Uichin Lee Receives Distinguished Paper Award from ACM
< Photo. Professor Uichin Lee (left) receiving the award >
KAIST (President Kwang Hyung Lee) announced on the 25th of October that Professor Uichin Lee’s research team from the School of Computing received the Distinguished Paper Award at the International Joint Conference on Pervasive and Ubiquitous Computing and International Symposium on Wearable Computing (Ubicomp / ISWC) hosted by the Association for Computing Machinery (ACM) in Melbourne, Australia on October 8.
The ACM Ubiquitous Computing Conference is the most prestigious international conference where leading universities and global companies from around the world present the latest research results on ubiquitous computing and wearable technologies in the field of human-computer interaction (HCI).
The main conference program is composed of invited papers published in the Proceedings of the ACM (PACM) on Interactive, Mobile, Wearable and Ubiquitous Technologies (IMWUT), which covers the latest research in the field of ubiquitous and wearable computing.
The Distinguished Paper Award Selection Committee selected eight papers among 205 papers published in Vol. 7 of the ACM Proceedings (PACM IMWUT) that made outstanding and exemplary contributions to the research community. The committee consists of 16 prominent experts who are current and former members of the journal's editorial board which made the selection after a rigorous review of all papers for a period that stretched over a month.
< Figure 1. BeActive mobile app to promote physical activity to form active lifestyle habits >
The research that won the Distinguished Paper Award was conducted by Dr. Junyoung Park, a graduate of the KAIST Graduate School of Data Science, as the 1st author, and was titled “Understanding Disengagement in Just-in-Time Mobile Health Interventions”
Professor Uichin Lee’s research team explored user engagement of ‘Just-in-Time Mobile Health Interventions’ that actively provide interventions in opportune situations by utilizing sensor data collected from health management apps, based on the premise that these apps are aptly in use to ensure effectiveness.
< Figure 2. Traditional user-requested digital behavior change intervention (DBCI) delivery (Pull) vs. Automatic transmission (Push) for Just-in-Time (JIT) mobile DBCI using smartphone sensing technologies >
The research team conducted a systematic analysis of user disengagement or the decline in user engagement in digital behavior change interventions. They developed the BeActive system, an app that promotes physical activities designed to help forming active lifestyle habits, and systematically analyzed the effects of users’ self-control ability and boredom-proneness on compliance with behavioral interventions over time.
The results of an 8-week field trial revealed that even if just-in-time interventions are provided according to the user’s situation, it is impossible to avoid a decline in participation. However, for users with high self-control and low boredom tendency, the compliance with just-in-time interventions delivered through the app was significantly higher than that of users in other groups.
In particular, users with high boredom proneness easily got tired of the repeated push interventions, and their compliance with the app decreased more quickly than in other groups.
< Figure 3. Just-in-time Mobile Health Intervention: a demonstrative case of the BeActive system: When a user is identified to be sitting for more than 50 mins, an automatic push notification is sent to recommend a short active break to complete for reward points. >
Professor Uichin Lee explained, “As the first study on user engagement in digital therapeutics and wellness services utilizing mobile just-in-time health interventions, this research provides a foundation for exploring ways to empower user engagement.” He further added, “By leveraging large language models (LLMs) and comprehensive context-aware technologies, it will be possible to develop user-centered AI technologies that can significantly boost engagement."
< Figure 4. A conceptual illustration of user engagement in digital health apps. Engagement in digital health apps consists of (1) engagement in using digital health apps and (2) engagement in behavioral interventions provided by digital health apps, i.e., compliance with behavioral interventions. Repeated adherences to behavioral interventions recommended by digital health apps can help achieve the distal health goals. >
This study was conducted with the support of the 2021 Biomedical Technology Development Program and the 2022 Basic Research and Development Program of the National Research Foundation of Korea funded by the Ministry of Science and ICT.
< Figure 5. A conceptual illustration of user disengagement and engagement of digital behavior change intervention (DBCI) apps. In general, user engagement of digital health intervention apps consists of two components: engagement in digital health apps and engagement in behavioral interventions recommended by such apps (known as behavioral compliance or intervention adherence). The distinctive stages of user can be divided into adoption, abandonment, and attrition. >
< Figure 6. Trends of changes in frequency of app usage and adherence to behavioral intervention over 8 weeks, ● SC: Self-Control Ability (High-SC: user group with high self-control, Low-SC: user group with low self-control) ● BD: Boredom-Proneness (High-BD: user group with high boredom-proneness, Low-BD: user group with low boredom-proneness). The app usage frequencies were declined over time, but the adherence rates of those participants with High-SC and Low-BD were significantly higher than other groups. >
2024.10.25 View 6761 -
KAIST Introduces a Wearable Robot that Walks and Puts itself on to Disabled Persons
< Photo 1. WalkON Suit F1 - walking demonstration >
KAIST researchers have unveiled a new wearable robot developed for completely paralyzed persons that can walk to them so that the user can wear it right out of their wheelchairs without the help from others. Also, it was announced that Professor Kyoungchul Kong's team from KAIST will be participating in the wearable robot category of the 3rd Cybathlon, which is being held four years after the team’s gold medal win in 2020.
KAIST (President Kwang-Hyung Lee) announced this new version of the wearable robot for paraplegic people, WalkON Suit F1, by Professor Kyoungchul Kong (CEO and founder of Angel Robotics) of KAIST Department of Mechanical Engineering on the 24th of October.
< Photo 2. (From left) Professor Kyoungchul Kong of the Department of Mechanical Engineering, Researcher Seunghwan Kim (the competing athlete), and PhD candidate Jeongsu Park (the leader of Team KAIST) >
WalkON Suit is a wearable robot for people suffering with paraplegic disabilities that the research team has been continuously researching since 2015. This robot targets to assist persons with American Spinal Injury Association (ASIA) Impairment Scale – A (complete paralysis) grade injury, the most severe level of paraplegia. Therefore, its development purpose is different from that of other rehabilitation therapy and muscle strength assisting robots currently being supplied nationally by Angel Robotics.
Professor Kong's research team first announced WalkON Suit 1 in 2016, and then introduced WalkON Suit 4 in 2020, increasing the walking speed to 3.2 km/h, achieving the normal walking speed of people with no disabilities. In addition, it demonstrated the ability to pass through obstacles such as narrow passages, doors, and stairs that can be encountered in daily life.
However, it had the same fundamental problem all wearable robots have, which is that they require the help of others to wear the robot. While you can walk without help from others once you are wearing the robot, you needed someone's help to put it on to begin with.
The newly released WalkON Suit F1 presented a technical solution to this fundamental problem. It applied a frontal-docking method instead of a rear-sitting method so that you can wear the robot right away without getting out of the wheelchair and into the robot, which would require help from others mid-transition.
< Photo 3. WalkON Suit F1 - suiting-up demonstration >
In addition, before wearing the robot, it can walk on its own like a humanoid robot and approaches the user. It is also implemented a function that actively controls the center of its weight against the pull of gravity so that it maintains balance without falling over even if the user pushes the robot otherwise. The outer design of the WalkON Suit F1, which crosses between a humanoid and a wearable robot, was done by Professor Hyunjoon Park of the Department of Industrial Design at KAIST.
The original function of the wearable robot has also been greatly improved. The performance of the balance control was improved to allow the free use of both hands in upright state, as well as the freedom to take several steps without a cane.
Technological advancements at the components level are also noteworthy. Through close collaboration with Angel Robotics, all core components of the robot, such as the motor, reducer, motor driver, and main circuit, have been domestically produced. The output density of the motor and reducer modules has been improved by about two folds (based on power per weight) compared to the research team's existing technology, and the control performance of the motor driver has been improved by about three times (based on frequency response speed) compared to the best overseas technology.
In particular, the embedded software technology of the motor driver has been significantly improved so that advanced motion control algorithms can be stably implemented without using expensive higher-level controllers. In addition, visual recognition system for obstacle detection and an AI board for neural network application have been installed.
< Figure 1. WalkON Suit F1 shape and main specifications >
Professor Kong explained, “WalkON Suit is the culmination of wearable robot technology for the disabled,” and added, “The numerous components, control, and module technologies derived from WalkON Suit are setting the standard for the entire wearable robot industry.”
Professor Kong’s research team revealed WalkON Suit F1 and announced that they will be participating in the 3rd Cybathlon, which is being held after four years since the last event. In this competition, which will be held on October 27, Professor Kong’s lab, the Exo Lab will be participating with Jeongsu Park, a Ph.D. Student, as the leader and Seunghwan Kim, the lab’s staff researcher with complete paralysis, as the competing athlete.
The difficulty of the missions in this competition has been significantly increased compared to the previous competition, and the number of missions has increased from six to ten. Some missions have been criticized for being overly challenging, going beyond the level that can be encountered in everyday life.
< Photo 4. Cybathlon stadium (Angel Robotics Asia Hub) >
Regarding this, the team leader Jeongsu Park expressed his ambition, saying, “Since we already won first place in the previous competition, our goal in this competition is to show the technological gap rather than competing for rankings.”
The Cybathlon is a cyborg Olympics held every four years in Switzerland. This competition will be held in a hybrid format, with some participants taking part in Switzerland while others broadcasting live from stadiums in their own country on October 27. Professor Kong's research team will be participating via live broadcast from the competition facilities installed in Angel Robotics' Advanced Research Institute (Planet Daejeon).
< Photo 5. Photo of Team KAIST participating in Cybathlon 2024 >
The demonstration video of WalkON Suit F1 can be viewed through the link below.
Link: https://www.youtube.com/@KyoungchulKong_EXO-Lab
2024.10.24 View 11673 -
The 3rd Global Entrepreneurship Summer School (GESS 2024) Successfully Completed in Silicon Valley
The 2024 Global Entrepreneurship Summer School (2024 KAIST GESS), hosted by the Office of Global Initiatives under the KAIST International Office (Director Man-Sung Yim), was held for the third time. This program allows students to visit Silicon Valley, a global startup hub, to directly experience its famous startup ecosystem and develop their capabilities for global expansion. A total of 20 students were selected through applications, interviews, final presentations, mentoring, and peer evaluations. Additionally, 17 students from the KAIST Impact MBA course at the KAIST Business School also participated.
Before starting the Silicon Valley program, participants received mentoring on business model development and pitching advice from a senior entrepreneur at KAIST for about two months, beginning last May. Afterward, they developed business items for each team at KAIST’s main campus in Daejeon. For seven days, starting from June 23rd, workshops were held under the themes of global entrepreneurship, learning through failure, capital and network, and startup culture at KOTRA Silicon Valley Trade Center, JP Morgan, and Plug and Play Tech Center. This program's lecture series provided prospective entrepreneurs with the opportunity to systematically learn the mindset and gain the experience needed to start a global business.
The participants also visited local companies and gained experience in the field of global technology startups. Visits included Bear Robotics (CEO John Ha), Soundable Health (CEO Cathering Song), ImpriMed (CEO Sungwon Lim), Phantom AI (CEO Hyunggi Cho), B Garage (CEO Aiden Kim), and Simple Steps (CEO Doyeon Kim). Lectures contained vivid experiences from Silicon Valley CEOs and company tours boosted the students' passion for entrepreneurship. In particular, Doyeon Kim, CEO of Simple Steps, which helps prevent career breaks for Korean female immigrants in Silicon Valley and allows talented female immigrants to demonstrate their abilities in society, said, “As a KAIST alumna entrepreneur, it was meaningful to share my experience with this generation of students who dream of starting a global business and creating social enterprises in the United States.”
This program also included a tour of Silicon Valley's big tech companies that have made a significant impact on the digital ecosystem through technological advancement and innovation. This included Broadcom, which maintains a strong global presence in the semiconductor and infrastructure software technology fields. At the invitation of Chairman Hock Tan, GESS participants had the opportunity to attend his lecture and ask questions. Chairman Tan, who received an honorary doctorate in engineering from KAIST last February, emphasized that experiencing failure and giving consistent effort over a long period of time are more important than anything else in order to grow as a global entrepreneur, and that technologies influencing the global market evolve over generations.
< Photo. Group photo of GESS 2024 participants at Broadcom with Chairman Hock Tan (center) ⓒBroadcom>
As part of this program, participants conducted a volunteer program called 'Let's play with AI+ Tech' with the Sunnyvale community in Silicon Valley and Foothill College to help grow together with the community. Through this program, GESS participants cultivated the virtues of a global leader. In this volunteer activity, low-income elementary school students and parents from the Sunnyvale community participated in chatbot training led by KAIST students, providing an opportunity to work with underprivileged groups in the local community.
In the final pitching event, the highlight of the program, local venture investors from Silicon Valley were invited as judges and evaluated the pitches for each team's business items. The participating students, who developed their own business models while receiving advice through face-to-face mentoring from a professional accelerator in Silicon Valley, showcased their creative and innovative ideas, presenting themselves as future global entrepreneurs. Merey Makhmutova (BS in Civil and Environmental Engineering) from the K-Bridge team, who won the final pitch, expressed her ambition: “Even before GESS pitch day, our team kept refining the pitch deck as we attended the lectures and benefitted from the mentoring. Our intense teamwork was a significant reason why we ultimately won first prize.” She added that K-Bridge aims to win an award at the upcoming UKC Pitching Competition and expressed her gratitude for being able to participate in this program. Arseniy Kan (BS in Electrical Engineering) from the KAIST Enablers team, who took second place, said, “The 2024 KAIST GESS Program became the most unforgettable and precious opportunity of my lifetime, and I dream of using this opportunity as a stepping stone to becoming a global entrepreneur.“ Additionally, Kangster (CEO Kang Kim), who won the Impact MBA final pitching session, had the opportunity to secure a meeting with a local investment company after their GESS final pitch.
The 2024 KAIST GESS was held in cooperation with the KAIST International Office, the KAIST College of Business, and Startup KAIST. Director Man-Sung Yim from the Office of Global Initiatives, who hosted the event, said, “KAIST students will grow into leaders with global influence and contribute to the international community by creating global value. At the same time, we hope to raise the international status of our university.” Professor Sangchan Park, who led the 17 Impact MBA students in this educational program, added, “Meeting with companies leading the global market and visiting Silicon Valley has been a valuable learning experience for students aiming to start a global startup.”
KAIST plans to continue promoting its global entrepreneurship education program by enriching its curriculum each year and helping students grow into entrepreneurs with the virtues of global leaders.
2024.07.03 View 8599