Advanced+bio
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KAIST begins full-scale cooperation with Taiwan’s Formosa Group
< (From left) Senior Vice President for Planning and Budget Kyung-Soo Kim, and Professor Minee Choi of the Department of Brain and Cognitive Sciences of KAIST along with Chairman of Formosa Group Sandy Wang and KAIST President Kwang-Hyung Lee, and Dean Daesoo Kim of KAIST College of Life Science and Bioengineering >
KAIST is pursuing cooperation in the fields of advanced biotechnology and eco-friendly energy with Formosa Plastics Group, one of Taiwan's three largest companies.
To this end, Chairman Sandy Wang, a member of Formosa Group's standing committee and leader of the group's bio and eco-friendly energy sector, will visit KAIST on the 13th of this month. This is the first time that the owner of Formosa Group has made an official visit to KAIST.
Cooperation between the two institutions began last March when our university signed a memorandum of understanding on comprehensive exchange and cooperation with Ming Chi University of Science and Technology (明志科技大學), Chang Gung University(長庚大學), and Chang Gung Memorial Hospital(長庚記念醫院), three of many institutions established and supported by Formosa Group.
Based on this, Chairman Sandy Wang, who visits our university to promote more exchanges and cooperation, talked about ‘the education of children and corporate social return and practice of his father, Chairman Yung-Ching Wang,’ through a special lecture for the school leadership as a part of the Monthly Lecture on KAIST’s Leadership Innovation Day.
She then visited KAIST's research and engineering facilities related to Taiwan's future industries, such as advanced biotechnology and eco-friendly energy, and discussed global industry-academic cooperation plans. In the future, the two organizations plan to appoint adjunct professors and promote practical global cooperation, including joint student guidance and research cooperation. We plan to pursue effective mid- to long-term cooperation, such as conducting battery application research with the KAIST Next-Generation ESS Research Center and opening a graduate program specialized in stem cell and gene editing technology in connection with Chang Gung University and Chang Gung Memorial Hospital. The newly established cooperative relationship will also promote Formosa Group's investment and cooperation with KAIST's outstanding venture companies related to bio and eco-friendly energy to lay the foundation for innovative industrial cooperation between Taiwan and Korea.
President Kwang-Hyung Lee said, “The Formosa Group has a global network, so we regard it to be a key partner that will position KAIST’s bio and engineering technology in the global stages.” He also said, “With Chairman Sandy Wang’s visit, Taiwan is emerging as a global economic powerhouse,” and added, “We expect to continue our close cooperative relationship with the company.”
Formosa Group is a company founded by the late Chairman Yung-Ching Wang, the father of Chairman Sandy Wang. As the world's No. 1 plastic PVC producer, it is leading the core industries of Taiwan's economy, including semiconductors, steel, heavy industry, bio, and batteries. Chairman Yung-Ching Wang was respected by the Taiwanese people by setting an example of returning his wealth to society under the belief that the companies and assets he built ‘belonged to the people.’ Chang Gung University, Chang Gung Memorial Hospital, and Ming Chi University of Technology, which are pursuing cooperation with our university, were also established as part of the social contribution promoted by Chairman Yung-Ching Wang and are receiving financial support from Formosa Group.
2024.05.09 View 1486 -
KAIST announced a novel technology to produce gasoline by a metabolically engineered microorganism
A major scientific breakthrough in the development of renewable energy sources and other important chemicals; The research team succeeded in producing 580 mg of gasoline per liter of cultured broth by converting in vivo generated fatty acids
For many decades, we have been relying on fossil resources to produce liquid fuels such as gasoline, diesel, and many industrial and consumer chemicals for daily use. However, increasing strains on natural resources as well as environmental issues including global warming have triggered a strong interest in developing sustainable ways to obtain fuels and chemicals.
Gasoline, the petroleum-derived product that is most widely used as a fuel for transportation, is a mixture of hydrocarbons, additives, and blending agents. The hydrocarbons, called alkanes, consist only of carbon and hydrogen atoms. Gasoline has a combination of straight-chain and branched-chain alkanes (hydrocarbons) consisted of 4-12 carbon atoms linked by direct carbon-carbon bonds.
Previously, through metabolic engineering of Escherichia coli (E. coli), there have been a few research results on the production of long-chain alkanes, which consist of 13-17 carbon atoms, suitable for replacing diesel. However, there has been no report on the microbial production of short-chain alkanes, a possible substitute for gasoline.
In the paper (entitled "Microbial Production of Short-chain Alkanes") published online in Nature on September 29, a Korean research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST) reported, for the first time, the development of a novel strategy for microbial gasoline production through metabolic engineering of E. coli.
The research team engineered the fatty acid metabolism to provide the fatty acid derivatives that are shorter than normal intracellular fatty acid metabolites, and introduced a novel synthetic pathway for the biosynthesis of short-chain alkanes. This allowed the development of platform E. coli strain capable of producing gasoline for the first time. Furthermore, this platform strain, if desired, can be modified to produce other products such as short-chain fatty esters and short-chain fatty alcohols.
In this paper, the Korean researchers described detailed strategies for 1) screening of enzymes associated with the production of fatty acids, 2) engineering of enzymes and fatty acid biosynthetic pathways to concentrate carbon flux towards the short-chain fatty acid production, and 3) converting short-chain fatty acids to their corresponding alkanes (gasoline) by introducing a novel synthetic pathway and optimization of culture conditions. Furthermore, the research team showed the possibility of producing fatty esters and alcohols by introducing responsible enzymes into the same platform strain.
Professor Sang Yup Lee said, "It is only the beginning of the work towards sustainable production of gasoline. The titer is rather low due to the low metabolic flux towards the formation of short-chain fatty acids and their derivatives. We are currently working on increasing the titer, yield and productivity of bio-gasoline. Nonetheless, we are pleased to report, for the first time, the production of gasoline through the metabolic engineering of E. coli, which we hope will serve as a basis for the metabolic engineering of microorganisms to produce fuels and chemicals from renewable resources."
This research was supported by the Advanced Biomass Research and Development Center of Korea (ABC-2010-0029799) through the Global Frontier Research Program of the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF), Republic of Korea. Systems metabolic engineering work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012-C1AAA001-2012M1A2A2026556) by MSIP through NRF.
Short-Chain Alkanes Generated from Renewable Biomass
This diagram shows the metabolic engineering of Escherichia coli for the production of short-chain alkanes (gasoline) from renewable biomass.
Nature Cover Page (September 29th, 2013)
2013.11.04 View 10908 -
Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11678