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Hidden Mechanism for the Suppression of Colon Cancer Identified
Published in Cell Reports : cells at the risk of causing colorectal cancer due to genetic mutation are discharged outside the colon tissue
Korean researchers have successfully identified the cancer inhibitory mechanism of the colon tissue. The discovery of the inherent defense mechanism of the colon tissues is expected to provide understanding of the cause of colorectal cancer.
The research was led by Kwang-Hyun Cho, a professor of Bio and Brain Engineering at KAIST (corresponding author) and participated by Dr. Jehun Song (the first author), as well as Dr. Owen Sansom, David Huels, and Rachel Ridgway from the Beatson Institute for Cancer Research in the UK and Dr. Walter Kolch from Conway Institute in Ireland.
The research was funded by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea, and its results were published in the 28th March online edition of Cell Reports under the title of “The APC network regulates the removal of mutated cells from colonic crypts.”
The organism can repair damaged tissues by itself, but genetic mutations, which may cause cancer, can occur in the process of cell division s for the repair. The rapid cell division s and toxic substances from the digestive process cause a problem especially in colon crypt that has a high probability for genetic mutation.
The research team was able to find out that the colon tissues prevent cancer by rapidly discharging carcinogenic cells with genetic mutations from the colon crypt durin ga frequent tissue repair process.
This defense mechanism, which inhibits abnormal cell division s by reducing the time mutated cells reside in the crypt, is inherent in the colon.
Extensive mathematical simulation results show that the mutated cells with enhanced Wnt signaling acquire increased adhesion in comparison to the normal cells, which therefore move rapidly toward the upper part of the crypt and are discharged more easily.
If beta-catenine, the key factor in Wnt signal transduction pathway, is not degraded due to genetic mutation, the accumulated beta-catenine activates cell proliferation and increases cell adhesion. The special environment of crypt tissue and the tendency of the cells with similar adhesion to aggregate will therefore discharge the mutated cell, hence maintaining the tissue homeostasis.
In vivo experiment with a mouse model confirms the simulation results that, in the case of abnormal crypt, the cells with high proliferation in fact move slower.
Professor Cho said, “This research has identified that multicellular organism is exquisitely designed to maintain the tissue homeostasis despite abnormal cell mutation. This also proves the systems biology research, which is a convergence of information technology and bio-technology , can discover hidden mechanisms behind complex biological phenomena.”
Crypt: Epithelium, consisting of approximately 2,000 cells, forms a colon surface in the shape of a cave.
Wnt Signaling: A signal transduction pathway involved in the proliferation and differentiation of cells that are particularly important for the embryonic development and management of adult tissue homeostasis.
2014.04.17 View 11225 -
KAIST and Hancom Inc. Join Hands for Software Development Projects
KAIST
(Steve Kang) and Hancom Inc. (Sang-Chul Kim) made an agreement on the 8th
of April for a partnership to jointly develop software industry. After the
ceremony, a TFT (Task Force Team) for industry-university collaboration was
established and a seminar to discuss cooperative projects ensued.
KAIST and
Hancom Inc. agreed to cooperate in three main areas at the seminar. They
included enhancing manpower in the Korean software industry, the technical
development of software applications, and creating a business model for the
expansion of the Korean software market globally.
KAIST
president Steve Kang said, "Noteworthy research achievements will result
from this great partnership with Hancom Inc. I believe this alliance will play an
important role in the development of Korean software industry."
“The
combination of KAIST's excellent talents and Hancom's software know-hows will produce market-winning results. We hope that mutual developments from the
two organizations through this practical industry-university collaboration will inspire many software companies to follow suit,” said Sang-Chul Kim, the president of Hancom
Inc.
2014.04.11 View 7341 -
Strawberries Delivered by A Miniature Drone at KAIST Spring Festival
The "HAPPY KAIST 2014 Spring Festival" held at KAIST from 4th April
The Cherry Blossoms Festival under the theme of "Cherry Blossoms: Light and Fantasy" held on 4th April
The Strawberry Party with strawberries exclusively delivered by a miniature drone on 11th April
KAIST is holding a spring festival from April 4th through 11th.
As a part of the "HAPPY KAIST 2014" event, cherry blossoms festival and strawberry party will be held at KAIST campus starting on April 4th.
This event has been organized with the purpose of creating a new culture and tradition for members of KAIST to unite. Faculty members, staff, and students have all contributed to making the festival a success.
The cherry blossoms festival, held under the theme of "Cherry Blossoms: Light and Fantasy," takes place at the road in front of the KAIST north dormitory, which provides a spectacular view of cherry blossom trees. It begins on the night of April 4th and continues until the 8th of April.
Around the cherry blossom tree road displays an art exhibition by the Design Rangers, a student club of graduate and doctorate students from the Department of Industrial Design at KAIST. The exhibition includes the "Fantasy Cherry Blossoms" and "Let’s Walk Together."
Following on the 11th will be the "Strawberry Party" to take place throughout the campus. The strawberry party began in 1995 in order to help the local strawberry farmers. Now, it has become KAIST’s own unique tradition attended by faculty, student clubs, and laboratory members.
This year, the fruit party becomes a unique event in that there will be a demonstration of strawberry delivery by an unmanned vehicle or an unmanned aerial vehicle (a miniature drone).
When a customer orders strawberries via a smart phone application, the user's current location is sent to the central system of an unmanned vehicle. Either the unmanned vehicle (UV) transports strawberries or for places
inaccessible
by the UV such as on a lawn, the drone delivers the fruit to the customer
.
This demonstration has been organized by Professor Hyunchul Shim from the Department of Aerospace Engineering at KAIST. Professor Shim said, “If the unmanned logistics system, such as the one being demonstrated at the Strawberry Party, is commercialized, both cost and time
in the logistics industry
can be significantly reduced.”
The HAPPY KAIST 2014,
organized
by the College of Engineering, is an annual event, consisting of a total of five programs, with the purpose to make the campus happier and
healthier.
2014.04.07 View 9223 -
When Technology Meets Spring: A Drone Delivering Strawberries Greets the Change of Seasons in KAIST
KAIST celebrates the arrival of spring by hosting a variety of cultural events for university members as well as the surrounding community members.
The "Happy KAIST 2014" will be held from April 4 to April 11th, which includes the “Cherry Blossoms Festival” and “Strawberry Party.” The event is free and open to the public.
As part of the strawberry party, visitors to the campus can order the fruit to be delivered to the place where they sit via a drone developed by Professor Hyunchul Shim of Aerospace Engineering at KAIST.
The strawberry delivery by a drone starts on April 11. Throughout the campus, the drone will deliver up to 100 containers of strawberries to customers.
Pictures:
A drone delivers a small container of strawberries ordered by students.
2014.04.04 View 8092 -
Professor Sang-Yup Lee Named the Winner of the Ho-Am Prize in 2014
The Ho-Am Prize, awarded by Samsung Group’s Ho-Am Foundation, was announced on April 2, 2014 in Seoul. Professor Sang-Yup Lee of Chemical and Biomolecular Engineering at KAIST was among the five recipients.
The prize is presented to Koreans who have made great contributions to the development of Korea in the field of science, engineering, medicine, arts, and philanthropy.
Professor Lee received the award in recognition of his pioneering research on systems metabolic engineering.
For the story written by Korea Joongang Daily, please go to the link below:
Ho-Am Foundation Names Annual Prize Winners
Korea Joongang Daily
April 3, 2014
http://koreajoongangdaily.joins.com/news/article/Article.aspx?aid=2987332
2014.04.03 View 9090 -
The First Winner of Sang Soo Lee Award in Optics and Photonics
The Optical Society of Korea and the Optical Society of America selected Mario Garavaglia, a researcher at the La Plata Optical Research Center in Argentina, as the first winner of the Sang Soo Lee Award.
Dr. Garavaglia has been selected to receive the award in recognition for his research and education in the field of optics and photonics in Argentina.
The Sang Soo Lee Award, co-established by the Optical Society of Korea and the Optical Society of America in 2012, is awarded to an individual who has made a significant impact in the field. Special considerations are made for individuals who have introduced a new field of research, helped establish a new industry, or made a great contribution to education in the field.
The award is sponsored by the late Doctor Sang Soo Lee's family, the Optical Society of Korea, and the Optical Society of America.
The late Doctor Sang Soo Lee (1925~2010) has been widely known as the 'father of optics' in Korea. He was an active educator, researcher, and writer. Dr. Lee served as the first director of the Korea Advanced Institute of Science (KAIS), the predecessor to KAIST, which was Korea's first research oriented university.
Dr. Lee also served as the 6th president of KAIST between 1989 to 1991 and was a KAIST professor of physics for 21 years. He oversaw the completion of 50 Ph.D. and 100 Master's students as well as published 230 research papers.
Philip Bucksbaum, the president of the Optical Society of America, commented,
"Garavaglia has been an example to the spirit of the Sang Soo Lee Award. The award is the recognition for his tireless efforts and commitment to the development of optics and photonics in Argentina through his teaching, research, and publications."
Jeong-Won Woo, the president of the Optical Society of Korea, said,
"The Sang Soo Lee Award is given to researchers who have consistently contributed to the development of the field. Garavaglia is a well respected researcher in Argentina, and we are truly happy with his selection."
Dr. Garavaglia established a spectroscopy, optic, and laser laboratory in Universidad Nacional de La Plata in 1966. He founded the Center for Optical Research in 1977 and served as the chief of the laboratory until 1991.
Dr. Garavaglia published over 250 research papers in the fields of classical optics, modern optics, photoemission spectroscopy, and laser spectroscopy. He has also received the Galileo Galilei Award from the International Commission for Optics in 1999.
2014.03.31 View 9784 -
KAIST Holds 'Wearable Computer Contest'
Application for ‘2014 Wearable Computer Contest’ until May 23rd
KAIST is holding the 2014 Wearable Computer Contest (WCC) sponsored by Samsung Electronics in November and is currently receiving applications until May 23rd.
Wearable Computer is a device that can be worn on body or clothing, which allows users to be connected while on the move. It is currently receiving attention as the next generation of computer industry that will replace smart phones.
The Wearable Computer Contest will be held under the topic “Smart Fashion to Simple Life” and will be divided into a designated topic contest and an idea contest.
In the “designated topic contest,” each group will compete with their prototypes based on their own ideas about a wearable computer that combines IT and fashion. A total of 15 teams that enter the finals after a document review will be provided with USD 1,400 for a prototype production, Samsung's smart IT devices, and a systematic training program.
For the “idea contest,” competitors will present their ideas for a wearable computer in a poster format. The teams qualified to continue onto the finals will be given an opportunity to create and exhibit a life-sized model.
Chairman of the Wearable Computer Contest (WCC), Professor Hoejun Yoo from the KAIST Department of Electrical Engineering said, “Wearable Computer is the major future growth industry that will lead IT industry after smart phones. I hope WCC will help nurture the future professionals in the field of wearable computer industry.”
The applications for the Wearable Computer Contest can be found on the main website (http://www.ufcom.org) until May 23rd. Both undergraduate and graduate students can participate as a team for the “designated topic contest,” and there are no qualifications required for those who enter the “idea contest.”
Last year, a total of 104 teams from universities all around Korea has participated in the Wearable Computer Contest. The finalist, team 'Jump' from Chungnam University, received the Award of the Minister of Science, ICT and Future Planning, Republic of Korea.
2014.03.28 View 9435 -
ACM Interactions: Demo Hour, March and April 2014 Issue
The
Association for Computing Machinery (ACM), the largest educational and scientific
computing society in the world, publishes a magazine called
Interactions
bi-monthly.
Interactions
is the flagship magazine
for the ACM’s Special Interest Group on Computer-Human Interaction (SIGCHI) with
a global circulation that includes all SIGCHI members.
In
its March and April 2014 issue, the Smart E-book was introduced. It was developed by Sangtae Kim, Jaejeung
Kim, and Soobin Lee at the Information Technology Convergence in KAIST
Institute, KAIST.
For
the article, please go to the link or download the .pdf files below:
Interactions,
March &
April 2014
Demo Hour: Bezel-Flipper
Bezel-Flipper
Interactions_Mar & Apr 2014.pdf
http://interactions.acm.org/archive/view/march-april-2014/demo-hour29
2014.03.28 View 9470 -
Partnership Agreement between KAIST and SK Telecom for Cyber Security
KAIST
and SK Telecom, one of the largest wireless telecommunications operators in
Korea, signed a memorandum of understanding on the industry and university cooperation
to establish a research center for cyber security on March 18, 2014.
The
center will conduct research projects to improve privacy protection, develop core
technologies needed for cyber security, train engineers and researchers, and
host seminars and conferences.
The
two organizations will implement the first joint research project on the
development of software-defined network-based solutions and universal subscriber
identity module-based personal identification solutions.
2014.03.26 View 6726 -
High Resolution 3D Blood Vessel Endoscope System Developed
Professor Wangyeol Oh of KAIST’s Mechanical Engineering Department has succeeded in developing an optical imaging endoscope system that employs an imaging velocity, which is up to 3.5 times faster than the previous systems. Furthermore, he has utilized this endoscope to acquire the world’s first high-resolution 3D images of the insides of in vivo blood vessel.
Professor Oh’s work is Korea’s first development of blood vessel endoscope system, possessing an imaging speed, resolution, imaging quality, and image-capture area. The system can also simultaneously perform a functional imaging, such as polarized imaging, which is advantageous for identifying the vulnerability of the blood vessel walls.
The Endoscopic Optical Coherence Tomography (OCT) System provides the highest resolution that is used to diagnose cardiovascular diseases, represented mainly by myocardial infarction.
However, the previous system was not fast enough to take images inside of the vessels, and therefore it was often impossible to accurately identify and analyze the vessel condition. To achieve an in vivo blood vessel optical imaging in clinical trials, the endoscope needed to be inserted, after which a clear liquid flows instantly, and pictures can be taken in only a few seconds.
The KAIST research team proposed a solution for such problem by developing a high-speed, high-resolution optical tomographic imaging system, a flexible endoscope with a diameter of 0.8 mm, as well as a device that can scan the imaging light within the blood vessels at high speed. Then, these devices were combined to visualize the internal structure of the vessel wall.
Using the developed system, the researchers were able to obtain high-resolution images of about 7 cm blood vessels of a rabbit’s aorta, which is similar size to human’s coronary arteries. The tomography scan took only 5.8 seconds, at a speed of 350 scans per second in all three directions with a resolution of 10~35㎛.
If the images are taken every 200 ㎛, like the currently available commercial vascular imaging endoscopes, a 7cm length vessel can be imaged in only one second.
Professor Wangyeol Oh said, “Our newly developed blood vessel endoscope system was tested by imaging a live animal’s blood vessels, which is similar to human blood vessels. The result was very successful.”
“Collaborating closely with hospitals, we are preparing to produce the imaging of an animal’s coronary arteries, which is similar in size to the human heart,” commented Professor Oh on the future clinical application and commercialization of the endoscope system. He added, “After such procedures, the technique can be applied in clinical patients within a few years.”
Professor Oh’s research was supported by the National Research Foundation of Korea and the Global Frontier Project by the Korean government. The research results were published in the 2014 January’s edition of Biomedical Optics Express.
Figure 1: End portion of optical endoscope (upper left)
Figure 2: High-speed optical scanning unit of the endoscope (top right)
Figure 3: High-resolution images of the inside of in vivo animal blood vessels (in the direction of vascular circumference and length)
Figure 4: High-resolution images of the inside of in vivo animal blood vessels (in the direction of the vein depth)
2014.03.25 View 10265 -
Professor Huen Lee to Receive Lifetime Achievement Award from the International Conference on Gas Hydrates
Professor Huen Lee of the Chemical and
Biomolecular Engineering Department at KAIST will receive a lifetime
achievement award at the 8th International Conference on Gas
Hydrates (ICGH) to be held from July 28, 2014 to August 2, 2014 in Beijing,
China.
Among his other scholarly and research accomplishments, Professor Lee achieved the development of natural gas by injecting
carbon dioxide and nitrogen into the layers of gas hydrates. With this
technology, ConocoPhilips, an American multinational energy corporation,
successfully extracted natural gas from the gas hydrates in the North Slope of
Alaska in the US in April 2012.
Meeting every three years in a different
country around the world, ICGH is a leading gathering of scientists and
engineers in gas hydrates. The 8th conference will be held under the
theme of “Opportunity and Challenge-Development and Utilization of Gas
Hydrates.”
2014.03.25 View 7007 -
Science Daily: Nanostructured Capsules Could Bring About Paints and Electronic Displays That Never Fade
A collaborative research by Professor Shin-Hyun Kim of Chemical and Bimolecular Engineering, KAIST, and his student, Tae-Min Choi, on nano-structural colors with Harvard University was published by Science Daily on March 14, 2014.
For the article, please go to:
Science Daily,
March 14, 2014
Featured Research
"Brighter inks, without pigment: Nanostructured capsules could bring about paints and electronic displays that never fade"
http://www.sciencedaily.com/releases/2014/03/140314164214.htm
2014.03.17 View 8306