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Professor Sang-Yup Lee Receives the Order of Service Merit Red Stripes from the Korean Government
The government of the Republic of Korea named Professor Sang-Yup Lee of the Department of Chemical and Bio-molecular Engineering at KAIST as the fiftieth recipient of the Order of Service Merit Red Stripes on May 19, 2015.
This medal is awarded to government employees, officials, and teachers in recognition of their contributions to public services including education.
Professor Lee is regarded as a leading scientist in the field of metabolic engineering, genomics, proteomics, metabolomics, and bioinformatics on microorganism producing various primary and secondary metabolites. He contributed significantly to the advancement of bio-based engineering research in Korea.
In addition, his research in microorganism metabolic engineering propelled him to the front of his field, making him the world’s founder of systems metabolic engineering, inventing numerous technologies in strain development.
Professor Lee has received many patent rights in bioprocess engineering. While at KAIST, he applied for 585 patents and registered 227 patents. In particular, he has applied for 135 patents and registered 99 patents in the past five years, successfully turning research results into commercial applications.
Professor Lee said, “I’m glad to contribute to the development of Korean science and technology as a researcher and teacher. I would like to share this honor with my students, master’s and doctoral students in particular, because without their support, it wouldn’t have been possible to pull off the highest level of research results recognized by this medal.”
2015.05.21 View 7255 -
System Approach Using Metabolite Structural Similarity Toward TOM Suggested
A Korean research team at KAIST suggests that a system approach using metabolite structural similarity helps to elucidate the mechanisms of action of traditional oriental medicine.
Traditional oriental medicine (TOM) has been practiced in Asian countries for centuries, and is gaining increasing popularity around the world. Despite its efficacy in various symptoms, TOM has been practiced without precise knowledge of its mechanisms of action. Use of TOM largely comes from empirical knowledge practiced over a long period of time. The fact that some of the compounds found in TOM have led to successful modern drugs such as artemisinin for malaria and taxol (Paclitaxel) for cancer has spurred modernization of TOM.
A research team led by Sang-Yup Lee at KAIST has focused on structural similarities between compounds in TOM and human metabolites to help explain TOM’s mechanisms of action. This systems approach using structural similarities assumes that compounds which are structurally similar to metabolites could affect relevant metabolic pathways and reactions by biosynthesizing structurally similar metabolites.
Structural similarity analysis has helped to identify mechanisms of action of TOM. This is described in a recent study entitled “A systems approach to traditional oriental medicine,” published online in Nature Biotechnology on March 6, 2015. In this study, the research team conducted structural comparisons of all the structurally known compounds in TOM and human metabolites on a large-scale. As a control, structures of all available approved drugs were also compared against human metabolites. This structural analysis provides two important results. First, the identification of metabolites structurally similar to TOM compounds helped to narrow down the candidate target pathways and reactions for the effects from TOM compounds. Second, it suggested that a greater fraction of all the structurally known TOM compounds appeared to be more similar to human metabolites than the approved drugs. This second finding indicates that TOM has a great potential to interact with diverse metabolic pathways with strong efficacy. This finding, in fact, shows that TOM compounds might be advantageous for the multitargeting required to cure complex diseases. “Once we have narrowed down candidate target pathways and reactions using this structural similarity approach, additional in silico tools will be necessary to characterize the mechanisms of action of many TOM compounds at a molecular level,” said Hyun Uk Kim, a research professor at KAIST.
TOM’s multicomponent, multitarget approach wherein multiple components show synergistic effects to treat symptoms is highly distinctive. The researchers investigated previously observed effects recorded since 2000 of a set of TOM compounds with known mechanisms of action. TOM compounds’ synergistic combinations largely consist of a major compound providing the intended efficacy to the target site and supporting compounds which maximize the efficacy of the major compound. In fact, such combination designs appear to mirror the Kun-Shin-Choa-Sa design principle of TOM.
That principle, Kun-Shin-Choa-Sa (君臣佐使 or Jun-Chen-Zuo-Shi in Chinese) literally means “king-minister-assistant-ambassador.” In ancient East Asian medicine, treating human diseases and taking good care of the human body are analogous to the politics of governing a nation. Just as good governance requires that a king be supported by ministers, assistants and/or ambassadors, treating diseases or good care of the body required the combined use of herbal medicines designed based on the concept of Kun-Shin-Choa-Sa. Here, the Kun (king or the major component) indicates the major medicine (or herb) conveying the major drug efficacy, and is supported by three different types of medicines: the Shin (minister or the complementary component) for enhancing and/or complementing the efficacy of the Kun, Choa (assistant or the neutralizing component) for reducing any side effects caused by the Kun and reducing the minor symptoms accompanying major symptom, and Sa (ambassador or the delivery/retaining component) which facilitated the delivery of the Kun to the target site, and retaining the Kun for prolonged availability in the cells.
The synergistic combinations of TOM compounds reported in the literature showed four different types of synergisms: complementary action (similar to Kun-Shin), neutralizing action (similar to Kun-Choa), facilitating action or pharmacokinetic potentiation (both similar to Kun-Choa or Kun-Sa). Additional structural analyses for these compounds with synergism show that they appeared to affect metabolism of amino acids, co-factors and vitamins as major targets.
Professor Sang Yup Lee remarks, “This study lays a foundation for the integration of traditional oriental medicine with modern drug discovery and development. The systems approach taken in this analysis will be used to elucidate mechanisms of action of unknown TOM compounds which will then be subjected to rigorous validation through clinical and in silico experiments.”
Sources: Kim, H.U. et al. “A systems approach to traditional oriental medicine.” Nature Biotechnology. 33: 264-268 (2015).
This work was supported by the Bio-Synergy Research Project (2012M3A9C4048759) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. This work was also supported by the Novo Nordisk Foundation.
The picture below presents the structural similarity analysis of comparing compounds in traditional oriental medicine and those in all available approved drugs against the structures of human metabolites.
2015.03.09 View 9438 -
Professor Sang Yup Lee Appointed Founding Board Member of Cell Systems
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed a member of the founding editorial board of the newly established journal Cell Systems.
Cell Systems will be a sister journal of Cell, one of the three most prestigious scientific journals along with Nature and Science, that publishes a wide range of papers on biological engineering. The first issue of Cell Systems will be published this July.
Cell Systems plans to publish innovative discoveries, reviews of various research instruments, and research findings on integrated and quantified systems in the field of biology.
Professor Lee is a pioneer in metabolic engineering of microorganism with a focus on biopolymers and metabolites production. He is the editor-in-chief of Biotechnology Journal and serves on the editorial board of numerous international journals. He is also a member of the Global Agenda Council of the World Economic Forum and the Presidential Advisory Committee on Science and Technology in Korea.
Professor Lee said, “Cell Systems will present research findings that discuss whole biological systems methodically.” He continued, “I hope many research findings of Korean scholars will be published in Cell Systems, which will become a representative journal of systems biology and systems biological engineering.”
2015.02.13 View 8549 -
Distinguished Professor Sang Yup Lee Accepts an Honorary Professorship at Beijing University of Chemical Technology
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed an honorary professor at Beijing University of Chemical Technology (BUCT). Founded in 1958, BUCT is one of the outstanding universities in mainland China, especially in chemistry studies.
In addition to the Chinese Academy of Sciences (2012), Shanghai Jiao Tong University (2013), Wuhan University (2014), and Hebei University of Technology (2014), this is the fifth honorary professorship Professor Lee has received from higher education institutions in China.
Professor Lee was recognized for his pioneering research in systems metabolic engineering of microorganisms necessary for the development of green chemical industries. He succeeded in producing succinic acid through bacterial fermentation and engineering plastic raw materials in the most effective and economical method for the first time in the world. Professor Lee also developed polylactic acid, a bio-based polymer that allows plastics to be produced through natural and renewable resources, as well as the microbial production of alkanes, an alternative to gasoline that can be produced from fatty acids.
Professor Lee has been actively working as a member of a group of global leaders supported by the World Economic Forum (WEF), serving as the Chairman of the Future of Chemicals, Advanced Materials & Biotechnology, Global Agenda Councils, WEF.
2014.11.13 View 10445 -
Wuhan University, China, Appoints Distinguished Professor Sang Yup Lee as Honorary Professor
Sang Yup Lee, Distinguished Professor of the Department of Chemical and Biomolecular Engineering at KAIST, has been appointed an honorary professor at Wuhan University in Hubei Province, China. This is the third time that Professor Lee has received an honorary professorship from Chinese academic institutions. The Chinese Academy of Sciences appointed him an honorary professor in 2012, and Shanghai Jia Tong University asked him to serve as an advisory professor in 2013, respectively.
Professor Lee was recognized for his pioneering research in systems metabolic engineering of microorganisms necessary for the development of green chemical industries. He succeeded in producing succinic acid through bacterial fermentation and engineering plastic raw materials in the most effective and economical method for the first time in the world. Professor Lee also developed polylactic acid, a bio-based polymer that allows plastics to be produced through natural and renewable resources, as well as the microbial production of alkanes, an alternative to gasoline that can be produced from fatty acids.
Professor Lee has been actively working as a member of a group of global leaders supported by the World Economic Forum (WEF), serving the Chairman of the Future of Chemicals, Advanced Materials & Biotechnology, Global Agenda Councils, WEF.
Wuhan University is a comprehensive and key national university selected by the Chinese government as a major recipient of state funding for research. It is also known as one of the most beautiful campuses in China.
2014.10.20 View 8572 -
Distinguished Professor Sang Yup Lee Gives Special Lecture at Tianjin University, China
Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering at KAIST gave a special lecture at Tianjin University, China, on September 12, 2014.
The university has invited prestigious scholars and scientists including Nobel Prize laureates from all around the world to their program called the "BeiYang Lecture Series."
Professor Lee said:
"The lecture series has invited many eminent global leaders such as Dr. Steven Chu, who received the Nobel Prize in Physics in 1997 and also served the 12th United States Secretary of Energy. It is a great honor to participate in the program as a speaker. The university told me that in recognition of my research in the development of sustainable biochemical industry through systems metabolic engineering, I was invited to speak.”
Professor Lee presented his speech entitled “Production of Chemical Materials through Microorganism Metabolic Systems Engineering” and took questions from the audience.
Professor Lee developed the world’s most efficient microorganism and bioprocess such as succinate, butanol, and engineering plastic raw materials. In recent years, he has succeeded in producing a small quantity of gasoline through converting in-vivo generated fatty acids.
2014.09.16 View 8389 -
Distinguished Professor Sang Yup Lee Participates in the 2014 Summer Davos Forum
Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering, KAIST, was invited to lead four sessions at the Annual Meeting 2014, the World Economic Forum, also known as the Summer Davos Forum, which was held in Tianjin, China, from September 10th to 12th.
Two of the four sessions Professor Lee participated in were held on September 10th. At the first session entitled “Biotechnology Ecosystem,” he examined with other panelists the future of bioengineering in depth and discussed major policies and industry trends that will be necessary for the development of future biotechnologies.
Professor Lee later attended the “Strategic Shifts in Healthcare” session as a moderator. Issues related to transforming the health industry such as the next-generation genomics, mobile health and telemedicine, and wearable devices and predictive analytics were addressed.
On September 12, Professor Lee joined the “IdeasLab with KAIST” and gave a presentation on nanotechnology. There was a total of ten IdeasLab sessions held at the Summer Davos Forum, and KAIST was the only Korean university ever invited to host this session. In addition to Professor Lee’s presentation, three more presentations were made by KAIST professors on such topics as “Sustainable Energy and Materials” and “Next-generation Semiconductors.”
Lastly, Professor Lee participated in the “Global Promising Technology” session with the World Economic Forum’s Global Agenda Council members. At this session, he explained the selection of the “World’s Top 10 Most Promising Technologies” and “Bio Sector’s Top 10 Technologies” and led discussions about the “2015 Top 10 Technologies” with the council members.
The Davos Forum has been announcing the “World’s Top 10 Most Promising Technologies” since 2012, and Professor Lee has played a key role in the selection while working as the Chairman of Global Agenda Council. The selection results are presented at the Davos Forum every year and have attracted a lot of attention from around the world.
2014.09.15 View 10649