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A Key Signal Transduction Pathway Switch in Cardiomyocyte Identified
A KAIST research team has identified the fundamental principle in deciding the fate of cardiomyocyte or heart muscle cells. They have determined that it depends on the degree of stimulus in β-adrenergic receptor signal transduction pathway in the cardiomyocyte to control cells' survival or death. The findings, the team hopes, can be used to treat various heart diseases including heart failure.
The research was led by KAIST Department of Bio and Brain Engineering Chair Professor Kwang-Hyun Cho and conducted by Dr. Sung-Young Shin (lead author) and Ph.D. candidates Ho-Sung Lee and Joon-Hyuk Kang. The research was conducted jointly with GIST (Gwangju Institute of Science and Technology) Department of Biological Sciences Professor Do-Han Kim’s team. The research was supported by the Ministry of Science, ICT and Future Planning, Republic of Korea, and the National Research Foundation of Korea. The paper was published in Nature Communications on December 17, 2014 with the title, “The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.”
The β-adrenergic receptor signal transduction pathway can promote cell survival (mediated by β2 receptors), but also can result in cell death by inducing toxin (mediated by β1 receptors) that leads to various heart diseases including heart failure. Past attempts to identify the fundamental principle in the fate determining process of cardiomyocyte based on β-adrenergic receptor signalling concluded without much success.
The β-adrenergic receptor is a type of protein on the cell membrane of cardiomyocyte (heart muscle cell) that when stimulated by neurohormones such as epinephrine or norepinephrine would transduce signals making the cardiomyocyte contract faster and stronger.
The research team used large-scale computer simulation analysis and systems biology to identify ERK* and ICER** signal transduction pathways mediated by a feed-forward circuit as a key molecular switch that decides between cell survival and death.
Weak β-adrenergic receptor stimulations activate ERK signal transduction pathway, increasing Bcl-2*** protein expression to promote cardiomyocyte survival. On the other hand, strong β-adrenergic receptor stimulations activate ICER signal transduction pathway, reducing Bcl-2 protein expression to promote cardiomyocyte death.
Researchers used a systems biology approach to identify the mechanism of B-blocker****, a common drug prescribed for heart failure. When cardiomyocyte is treated with β1 inhibitor, strong stimulation on β-adrenergic receptor increases Bcl-2 expression, improving the chance of cardiomyocyte survival, a cell protection effect.
Professor Kwang-Hyun Cho said, “This research used systems biology, an integrated, convergence research of IT (information technology) and BT (biotechnology), to successfully identify the mechanism in deciding the fate of cardiomyocytes based on the β-adrenergic receptor signal transduction pathway for the first time. I am hopeful that this research will enable the control of cardiomyocyte survival and death to treat various heart diseases including heart failure.”
Professor Cho’s team was the first to pioneer a new field of systems biology, especially concerning the complex signal transduction network involved in diseases. Their research is focused on modelling, analyzing simulations, and experimentally proving signal pathways. Professor Cho has published 140 articles in international journals including Cell, Science, and Nature.
* ERK (Extracellular signal-regulated kinases): Signal transduction molecule involved in cell survival
** ICER (Inducible cAMP early repressor): Signal transduction molecule involved in cell death
*** Bcl-2 (B-cell lymphoma 2): Key signal transduction molecule involved in promotion of cell survival
**** β-blocker: Drug that acts as β-adrenergic receptor inhibitor known to slow the progression of heart failure, hence used most commonly in medicine.
Picture: A schematic diagram for the β-AR signalling network
2015.01.05 View 12279 -
Professor Mikyoung Lim Receives the MediaV Young Researcher Award
Professor Mikyoung Lim of the Department of Mathematical Sciences at KAIST received the MediaV Young Researchers Award at the International Conference on Inverse Problems and Related Topics that took place at the National Taiwan University, Taiwan, on December 15-19, 2014.
The Conference established the MediaV Young Researcher Award in 2010 to recognize distinguished scholars who are age 40 or younger and have made important contributions to the field of inverse problems. This year, two recipients were chosen for the award.
Professor Lim has focused her research on the incremental reading of incomprehensible materials’ imaging and the effect of invisibility cloaking.
The other awardee was Kui Ren, a professor at the University of Texas at Austin.
2014.12.27 View 9821 -
KAIST wins second place in unmanned boat competition
KAIST took second place in an international competition to promote technologies of the autonomous underwater vehicle (AUV).
Professor Jin-hwan Kim’s research team from KAIST’s Ocean Systems Engineering Department won the second place in Maritime RobotX Challenge which took place for the first time from October 20 - 26 in Marina Bay, Singapore.
Along with automobiles and drones, the necessity for unmanned boats has grown. To encourage and examine the development of these technologies, the U.S. Office of Naval Research decided to organize an unmanned boat competition which took place for the first time this year.
After three teams were selected from a domestic competition in each countries, a total of fifteen teams from five countries from the Pacific Rim including Korea, the United States, Australia, Japan, and Singapore competed. Teams from such universities as MIT, Tokyo University, Tokyo Institute of Technology, National University of Singapore, Nanyang Technological University, and Queensland University of Technology participated. In addition to KAIST, Seoul National University and Ulsan University participated.
Using a 4.5 meters long and 2.5 meters wide unmanned boat provided by the organizer, each team had to implement an integrated system that combined a propulsion system, hardware, and autonomous software. Each team’s vessel had to perform tasks without manual control, employing autonomous driving through recognition of the course, searching underwater for acoustic sources, automatically approaching piers, remote observation of buoy, and avoidance and detection of obstacles.
Although KAIST outpaced MIT in the semifinal which selected six out of fifteen teams, it won the second place in the final. As well as winning second prize, KAIST also won best website prize and a special prize from the competition sponsor, Northrop Grumman Corporation, an American defense technology company, totaling 16,500 U.S. dollars of prize money.
The Vice President for Planning and Budget, Professor Seungbin Park said, “It was a great opportunity to showcase the advanced unmanned robot technology of Korea.” He added that “this raised KAIST’s reputation as a global research oriented university.”
Professor Kim commented, “Along with automobiles and drones, the necessity for the development of unmanned ocean vehicles such as unmanned boats and submarines are recognized these days.” He added that “the use of unmanned boats will make the process of channel investigation, ocean exploration, surveillance over water territories safer and more effective.”
Professor Kim’s team was sponsored by the U.S. Office of Naval Research, Samsung Heavy Industries, Sonar Tech, Daeyang Electric, and Red-one Technology.
KAIST Team's Unmanned Boat
The Competition's Missions
2014.12.12 View 10345 -
KAIST Partners with Science-focused Universities in Korea for Student Exchange Programs
KAIST and four science-focused universities in Korea (Pohang University of Science and Technology, Gwangju Institute of Science and Technology, Daegu Gyeongbuk Institute of Science and Technology, and Ulsan National Institute of Science and Technology) agreed to exchange programs during academic semesters including summer and winter terms by signing a memorandum of understanding (MOU) on November 28, 2014. The signing ceremony took place at the KAIST campus with the participation of academic affairs deans from all five universities.
Based on the agreement, KAIST students can take up to 12 credits of coursework at any of the said universities and have unimpeded access to the university facilities during their coursework.
Dean Hyun-Wook Park of Academic Affairs at KASIT said, “Through exchange programs, students can capitalize on each university’s advantages, and this eventually will lead to greater advancement in science and technology in the nation.”
2014.12.08 View 7576 -
SmileGate Membership Program for Students and Video Game Industry in Korea
The Office of University and Industry Cooperation at KAIST and SmileGate, a video game developer based in Korea, agreed in June 2014 to cooperate in the development of talents for the video game industry in Korea and to support students’ startup efforts.
The company established the SmileGate Studio at the KAIST campus in 2010 and has been supporting KAIST students who are interested in video game design and development, such as hosting design competitions and offering networking opportunities as well as consulting services for startups.
The Studio launched a scholarship program called the “SmileGate Membership” in November this year to offer 12 students research funding, equipment and tools for game design and development, and mentoring services for eight months. Participating students will also receive free space for research and development, legal services for business development, investment advice, and assistance in networking with the global community after the completion of the program.
Professor Joongmyeon Bae, the Dean of the KAIST Office of University and Industry Cooperation, said, “This is a great opportunity for our students because they can actually utilize their passion and creativity to make their own games. KAIST and SmileGate will continue to lead the video game industry in Korea through close collaboration.”
2014.12.03 View 8090 -
Broadband and Ultrathin Polarization Manipulators Developed
Professor Bumki Min from the Department of Mechanical Engineering at KAIST has developed a technology that can manipulate a polarized light in broadband operation with the use of a metamaterial.
It is expected that this technology will lead to the development of broadband optical devices that can be applied to broadband communication and display.
When an object or its structure is analyzed by using a polarized light such as a laser, the results are generally affected by the polarized state of the light. Therefore, in an optics laboratory, the light is polarized by various methods.
In such cases, researchers employ wave plates or photoactive materials. However, the performance of these devices depend vastly on wavelength, and so they are not suitable to be used as a polarizer, especially in broadband.
There were many attempts to make artificial materials that are very photoactive by using metamaterials which have a strong resonance. Nonetheless, because the materials had an unavoidable dispersion in the resonance frequency, they were not adequate for broadband operation.
Professor Min’s research team arranged and connected helical metamaterials that are smaller than the wavelength of light. They verified theoretically and experimentally that polarized light can be constantly rotated regardless of the wavelength by super-thin materials that have thickness less than one-tenth of the wavelength of the light. The experiment which confirmed the theory was conducted in the microwave band.
Broadband polarized rotational 3D metamaterials were found to rotate the polarized microwave within the range of 0.1 GHz to 40 GHz by 45 degrees regardless of its frequency. This nondispersive property is quite unnatural because it is difficult to find a material that does not change in a wide band.
In addition, the research team materialized the broadband nondispersive polarized rotational property by designing the metamaterial in a way that it has chirality, which determines the number of rotations proportional to the wavelength.
Professor Min said, “As the technology is able to manipulate ultrathin polarization of light in broadband, it will lead to the creation of ultra-shallow broadband optical devices.”
Sponsored by the Ministry of Science, ICT and Future Planning of the Republic of Korea and the National Research Foundation of Korea, this research was led by a PhD candidate, Hyun-Sung Park, under the guidance of Professor Min. The research findings were published online in the November 17th issue of Nature Communications.
Figure 1 – Broadband and Ultrathin Polarization Manipulators Produced by 3D Printer
Figure 2 – Concept of Broadband and Ultrathin Polarization Manipulators
2014.12.03 View 10501 -
Structure of Neuron-Connecting Synaptic Adhesion Molecules Discovered
A research team has found the three-dimensional structure of synaptic adhesion molecules, which orchestrate synaptogenesis. The research findings also propose the mechanism of synapses in its initial formation. Some brain diseases such as obsessive compulsive disorder (OCD) or bipolar disorders arise from a malfunction of synapses. The team expects the findings to be applied in investigating pathogenesis and developing medicines for such diseases.
The research was conducted by a Master’s candidate Kee Hun Kim, Professor Ji Won Um from Yonsei University, and Professor Beom Seok Park from Eulji University under the guidance of Professor Homin Kim from the Graduate School of Medical Science and Engineering, KAIST, and Professor Jaewon Ko from Yonsei University. Sponsored by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea, the research findings were published online in the November 14th issue of Nature Communications.
A protein that exists in the neuronal transmembrane, Slitrk, interacts with the presynaptic leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) and forms a protein complex. It is involved in the development of synapses in the initial stage, and balances excitatory and inhibitory signals of neurons.
It is known that a disorder in those two proteins cause a malfunction of synapses, resulting in neuropsychosis such as autism, epilepsy, OCD, and bipolar disorders. However, because the structure as well as synaptogenic function of these proteins were not understood, the development of cures could not progress.
The research team discovered the three-dimensional structure of two synaptic adhesion molecules like Slitrk and LAR-RPTPs and identified the regions of interaction through protein crystallography and transmission electron microscopy (TEM). Furthermore, they found that the formation of the synapse is induced after the combination of two synaptic adhesion molecules develops a cluster.
Professor Kim said, “The research findings will serve as a basis of understanding the pathogenesis of brain diseases which arises from a malfunction of synaptic adhesion molecules. In particular, this is a good example in which collaboration between structural biology and neurobiology has led to a fruitful result.” Professor Ko commented that “this will give new directions to synaptic formation-related-researches by revealing the molecular mechanism of synaptic adhesion molecules.”
Figure 1: Overview of the PTPd Ig1–3/Slitrk1 LRR1 complex.
Figure 2: Representative negative-stained electron microscopy images of Slitrk1 Full ectodomain (yellow arrows indicate the horseshoe-shaped LRR domains). The typical horseshoe-shaped structures and the randomness of the relative positions of each LRR domain can be observed from the two-dimensional class averages displayed in the orange box.
Figure 3: Model of the two-step presynaptic differentiation process mediated by the biding of Slitrks to LAR-RPTPs and subsequent lateral assembly of trans-synaptic LAR-RPTPs/Slitrik complexes.
2014.11.28 View 10936 -
Elsevier Selects a KAIST Graduate's Paper as the Top Cited Papers in 2011-2012
Dr. Myung-Won Seo, a graduate from the Department of Chemical and Bimolecular Engineering at KAIST, published a paper in January 2011 in Chemical Engineering Journal, which was entitled “Solid Circulation and Loop-seal Characteristics of a Dual Circulating Fluidized Bed: Experiments and CFD Simulation.” His paper was selected by Elsevier as the Top Cited Papers of 2011-2012. The Chemical Engineering Journal is a renowned peer-reviewed journal issued by Elsevier.
Dr. Seo published another paper, “CFD Simulation with Experiments in a Dual Circulating Fluidized Bed Gasifier,” in January 2012 in Computers & Chemical Engineering, which was also selected as the Most Downloaded Papers in 2012-2013.
Dr. Seo graduated with a doctoral degree from KAIST in 2011. He is currently working at the Clean Fuel Laboratory, the Korea Institute of Energy Research, Daejeon, as a researcher. His research areas are coal gasification, upgrading, and liquefaction, as well as energy and chemical production from low-grade fuels such as biomass and wastes.
2014.11.24 View 8757 -
KAIST Robotic Art: Exhibit called "Artificial Brain, Robots Evolve"
It is not difficult to find the desire to create a Neoanthropinae in the history of mankind. Humans evolve through man-made extensions and live by self-training them. This is Seung Hyun Son’s description which encourages us to discuss the changes man-made humanoids would bring to our future lives. He depicts this in “Theory of Evolution: From mankind to humanoid” in the “Artificial Brain, Robots Evolve” exhibition in the KI Building, KAIST, from 21 November 2014 to 8 February 2015.
KAIST's Art and Design Committee (led by President Myung Seok Kim) is holding the third experimental art exhibition based on the integration of science and art. The previous exhibition themes were “See the Sky” in 2012 and “Life is Beautiful” in 2013. The exhibition is divided into five subtopics: Move, Feel, Think, Express, and Experiment in Imagination.
The exhibits are by 17 artists including Nam June Paik, Nancy Lang, and KAIST Professor Myung Seok Kim. The main exhibits include “Cloud Face,” by Seung Baek Shin and Yong Hoon Kim, that shows up as error on computer but can be seen by human eyes and “Brains in Vat," by Boo Rok Lee and Myung Chul Kim based on KAIST's robotic lab’s materials and motif. Also, “The May of My Life” by Professor Myung Seok Kim’s lab reminds us of the relationship between robot and human.
President Myung Seok Kim said, “The range of content in cultural art will inspire students’ imagination.” He continued, “I hope this exhibition will awaken both scientific ideas and artistic sense.”
The opening ceremony of the exhibition will be held from 14:00, 21 November. The “Artificial Brain, Robots Evolve” exhibition is hosted by the Daejeon Museum of Art and sponsored by National Museum of Modern and Contemporary Art and Soma Museum.
Pictures from top to bottom are Cloud Face, Brains in Vat, The May of My Life_1, and The May of My Life_2.
2014.11.21 View 7317 -
The 2014 Wearable Computer Competition Takes Place at KAIST
“This is a smart wig for patients who are reluctant to go outdoors because their hair is falling out from cancer treatment.”
A graduate student from Sungkyunkwan University, Jee-Hoon Lee enthusiastically explains his project at the KAIST KI Building where the 2014 Wearable Computer Competition was held. He said, “The sensor embedded inside the wig monitors the heart rate and the body temperature, and during an emergency, the device warns the patient about the situation. The product emphasizes two aspects; it notifies the patient in emergency situations, and it encourages patients to perform outdoor activities by enhancing their looks.”
The the tenth anniversary meeting of the 2014 Wearable Computer Competition took place at the KAIST campus on November 13-14, 2014.
A wearable computer is a mobile device designed to be put on the body or clothes so that a user can comfortably use it while walking. Recently, these devices that are able to support versatile internet-based services through smartphones are receiving a great deal of attention.
Wearable devices have been employed in two categorizes: health checks and information-entertainment. In this year’s competition, six healthcare products and nine information-entertainment products were exhibited.
Among these products, participants favored a smart helmet for motorcycle drivers. The driver can see through a rear camera with a navigation screen of the smartphone and text messages through the screen installed in the front glass of the helmet. Another product included a uniform that can control presentation slides by means of motion detection and voice recognition technology. Yet another popular device offered an insole to guide travelers to their destination with the help of motion sensors.
The chairman of the competition, Professor Hoi-Jun Yoo from the Department of Electrical Engineering at KAIST said, “Wearable devices such as smart watches, glasses, and clothes are gaining interest these days. Through this event, people will have a chance to look at the creativity of our students through the display of their wearable devices. In turn, these devices will advance computer technology.”
The third annual wearable computer workshop on convergence technology of wearable computers followed the competition. In the workshop, experts from leading information technology companies such as Samsung Electronics, LG Electronics, and KT Corporation addressed the convergence technology of wearable computers and trends in the field.
2014.11.19 View 9485 -
The Website of the KAIST Industrial Design Department Receives a Design Award
The 10th QS-Apple Higher Education Conference and Exhibition took place on November 11-13, 2014 in Taipei, Taiwan. The conference was hosted by Quacquarelli Symonds, a British company specializing in education, which publishes annually its world university rankings. Apple stands for Asia Pacific Professional Leaders in Education.
The QS-Apple conference supports the internationalization of Asia Pacific universities by providing opportunities for networking, exchanging best practices, and discussing recent developments in higher education. During the conference, the organizers presented the Creative Awards for best international education promotional designs in four categories: Website Pages, Video, Print Advertisement, and International Student Recruitment Brochures.
KAIST’s Industrial Design Department received the Best Website Pages Award for their website in recognition of high levels of user convenience and satisfaction as well as English language services. A total of 39 universities in the Asia and Pacific region competed in this category, and Nanyang Technological University in Singapore came in second place, followed by Hong Kong Baptist University in third.
2014.11.13 View 8138 -
A KAIST Student Team Wins the ACM UIST 2014 Student Innovation Contest
A KAIST team consisted of students from the Departments of Industrial Design and Computer Science participated in the ACM UIST 2014 Student Innovation Contest and received 1st Prize in the category of People’s Choice.
The Association for Computing Machinery (ACM) Symposium on User Interface Software and Technology (UIST) is an international forum to promote innovations in human-computer interfaces, which takes place annually and is sponsored by ACM Special Interest Groups on Computer-Human Interaction (SIGCHI) and Computer Graphics (SIGGRAPH). The ACM UIST conference brings together professionals in the fields of graphical and web-user interfaces, tangible and ubiquitous computing, virtual and augmented reality, multimedia, and input and output devices.
The Student Innovation Contest has been held during the UIST conference since 2009 to innovate new interactions on state-of-the-art hardware. The participating students were given with the hardware platform to build on—this year, it was Kinoma Create, a JavaScript-powered construction kit that allows makers, professional product designers, and web developers to create personal projects, consumer electronics, and "Internet of Things" prototypes. Contestants demonstrated their creations on household interfaces, and two winners in each of three categories -- Most Creative, Most Useful, and the People’s Choice -- were awarded.
Utilizing Kinoma Create, which came with a built-in touchscreen, WiFi, Bluetooth, a front-facing sensor connector, and a 50-pin rear sensor dock, the KAIST team developed a “smart mop,” transforming the irksome task of cleaning into a fun game. The smart mop identifies target dirt and shows its location on the display built in the rod of a mop. If the user turns on a game mode, then winning scores are gained wherever the target dirt is cleaned.
The People’s Choice award was decided by conference attendees, and they voted the smart mop as their most favorite project.
Professor Tek-Jin Nam of the Department of Industrial Design at KAIST, who advised the students, said, "A total of 24 teams from such prestigious universities as Carnegie Mellon University, Georgia Institute of Technology, and the University of Tokyo joined the contest, and we are pleased with the good results. Many people, in fact, praised the integration of creativity and technical excellence our have shown through the smart mop.”
Team KAIST: pictured from right to left, Sun-Jun Kim, Se-Jin Kim, and Han-Jong Kim
The Smart Mop can clean the floor and offer users a fun game.
2014.11.12 View 10234