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Prof. Sang-Min Bae Receives 2017 iF Design Award
Prof. Sang-Min Bae and his research team from the Industrial Design Department of KAIST submitted a winning entry to the 2017 iF Design Award named ‘Culture BOXCHOOL’. The iF Design Award is an internationally renowned design contest that is recognized as one of the top three design awards in the world along with the Red Dot Design Award and the IDEA Design Award. It has been held annually by iF International Forum Design since 1953. A total of 5,575 entries from 59 countries entered the last competition. Culture BOXCHOOL is a modular container space platform designed for culture sharing in isolated areas. It is delivered as a standard shipping container along with its subsidiary modular parts and it transforms into a gallery, office, or classroom. These modular parts build the interior and exterior by attaching them to the corner castings, which are standard parts on all shipping containers. Two Cultural BOXCHOOL containers can be transformed into three different types of layouts. The containers can generate their own energy using solar panels that provide sustainable energy to equipment inside. Additionally, hot humid air can flow out through the attic vent, doors, and windows. “With Culture BOXCHOOL, you can easily and quickly create spaces such as offices and classrooms, or you can easily disassemble and move them to another location. Thus, it can provide everyone with equal educational opportunities and cultural enjoyment regardless of their geographical location. In addition, because it produces its own energy, it is expected to create a cultural space in a relatively harsh environment such as in developing countries. These social and economic values of Culture BOXCHOOL seem to be what led to us winning the contest. I will continue to strive to create the world’s best designs for needy people.” Professor Bae said. The ID+IM design laboratory, a research team led by Professor Bae, has been studying philanthropy design since 2005, working on solving various problems throughout society through innovative design. They have received more than 50 awards from the most prestigious design competitions in the world.
2017.05.18
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Dr. Zi Jing Wong Named 2017 Jeong Hun Cho Awardee
(Photo caption: The 2017 Jeong Hun Cho Scholarship recipients pose with President Shin (left photo) and Dr. Zi Jing Wong, the recipient of the 2017 Jeong Hun Cho Award) Dr. Zi Jing Wong, a postdoctoral scholar at the University of California, Berkeley was named the 2017 recipient of the Jeong Hun Cho Award. The award recognizes outstanding young scientists in the field of aerospace engineering annually. The recipient receives a 20 million KRW prize. The Award Committee said that Dr. Wong who earned his MS at KAIST Department of Aerospace Engineering is a rising scholar in the fields of optic meta materials, photonics, imaging, among others. He has published five papers on the realization of a zero refractive index and the control of a refractive index, as well as the realization of a 3D invisibility cloak in Science and Nature Photonics in 2014 and 2015. Dr. Wong also swept the best paper awards from many international academic societies including the US Materials Research Society, IEEE, SPIE, and Metamaterials Congress in 2015. He finished his Ph.D. at the University of California, Berkeley. The Award Committee also named three recipients of the Jeong Hun Cho Scholarship: Ph.D. candidate Hyon-Tak Kim of the Department of Aerospace Engineering at KAIST, Ph.D. candidate Ho-Song Park from the Department of Mechanical Engineering at Korea University, and Hyong-Jin Choi of Kongju National University High School. The award was endowed by the family of the late Ph.D. candidate Jeong Hun Cho who died in a rocket lab accident in the Department of Aerospace Engineering in 2003. Cho was posthumously conferred an honorary doctorate degree. In memory of Cho, his father established the ‘Jeong Hun Cho Award and Scholarship.’ The scholarship annually selects three young scholars from Cho’s alma maters of KAIST, Korea University, and Kongju National University High School.
2017.05.12
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Study Identifies the Novel Molecular Signal for Triggering Septic Shock
Professor Seyun Kim’s team at the Department of Biological Sciences reported the mechanism by which cellular signaling transduction networks are precisely controlled in mediating innate immune responses, such as sepsis, by the enzyme IPMK (Inositol polyphosphate multikinase) which is essential for inositol biosynthesis metabolism. In collaboration with Professor Hyun Seong Roh at Seoul National University, the study’s first author, Eunha Kim, a Ph.D. candidate in Department of Biological Sciences, performed a series of cellular, biochemical, and physiological experiments searching for the new function of IPMK enzymes in macrophages. The research findings were published in Science Advances on April 21. Professor Kim’s team has been investigating various inositol metabolites and their biosynthesis metabolism for several years and has multilaterally identified the signaling actions of IPMK for controlling cellular growth and energy homeostasis. This research showed that the specific deletion of IPMK enzymes in macrophages could significantly reduce levels of inflammation and increase survival rates in mice when they were challenged by microbial septic shock and endotoxins. This suggests a role for IPMK enzymes in mediating innate inflammatory responses that are directly related to a host’s defense against pathogenic bacterial infection. The team further discovered that IPMK enzymes directly bind to TRAF6 proteins, a key player in immune signaling, thus protecting TRAF6 proteins from ubiquitination reactions that are involved in protein degradation. In addition, Kim and his colleagues successfully verified this IPMK-dependent immune control by employing short peptides which can specifically interfere with the binding between IPMK enzymes and TRAF6 proteins in macrophage cells. This research revealed a novel function of IPMK enzymes in the fine tuning of innate immune signaling networks, suggesting a new direction for developing therapeutics targeting serious medical conditions such as neuroinflammation, type 2 diabetes, as well as polymicrobial sepsis that are developed from uncontrolled host immune responses. This research was funded by the Ministry of Science, ICT and Future Planning. (Figure: Deletion of IPMK (inositol polyphosphate multikinase) in macrophages reduces the stability of TRAF6 protein which is the key to innate immune signaling, thereby blocking excessive inflammation in response to pathological bacterial infection.)
2017.05.11
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Professor Lee Recognized by the KMS as Best Paper Awardee
Professor Ji Oon Lee of the Department of Mathematical Sciences was selected as the 2017 Best Paper Awardee by the Korean Mathematical Society. The award will be presented during the KMS spring meeting on April 29. Dr. Lee is being honored for proving a necessary and sufficient condition for the Tracy-Wisdom law of Wigner matrices. In a paper titled ‘A Necessary and Sufficient Condition for Edge Universality of Wigner Matrices,’ he proposed a solution for one of the many unanswered problems in the field of random matrix theory that have existed for decades. The paper, co-authored with Professor Jun Yin at the University of Wisconsin – Madison, was published in the Duke Mathematical Journal in 2014. Professor Lee joined KAIST in 2010 after finishing his Ph.D. at Harvard University. He was named a ‘POSCI Science Fellow’ and received the ‘Young Scientist Award’ from the KMS in 2014.
2017.04.27
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Seeking a New Economic and Industrial Paradigm
The School of Humanities & Social Science will offer the open lecture course titled ‘Seeking a New Economic and Industrial Paradigm’ from May11 to June 7. This is part of a quarterly lecture series run by the school and open to the public. The open lecture is designed to provide opportunities for the public to identify future challenges and opportunities for Korea’s economy and industry. Experts in macroeconomics, finance, and global collaboration will provide glimpses of new directions for each sector as well as megatrends of emerging technologies on the heels of the 4th Industrial Revolution. Jin Hyuk Yoo from the Bank of Korea will speak on the ‘Outlook and Challenges of the Korean Economy.’ He will identify the current economic situation and explain how to build on sustainable long-term economic growth in the opening course. Won-Bin Lee of the Korea Institute for Industrial Economics & Trade will present on the ‘New Industrial Policy in the Era of the Fourth Industrial Revolution.’ His lecture will focus on fostering the local industry and creating its own ecosystem for furthering regional industries. Dong-Hoon Lee of Donga ST will speak on the implications that the Fourth Industrial Revolution will bring about in the medical industry. Won-Suk Choi of FnPricing will introduce the FN business model, presenting the risks and benefits of fintech in his lecture ‘Finance: Human and Technology.’ Jae-Hong Choi of the Institute of International Development Cooperation at Korea University will give a talk titled ‘Toward the World through Global Cooperation.’ He will present on the history of Korea’s global cooperation initiatives and the role of KOICA, introducing its emerging economic and industrial cooperation model. Professor Jeounghoon Kim, who is responsible for the public lecture program, said, “Korea now faces very diverse social economic and industrial challenges and we seem to be lost while searching for a solution. The public will have an opportunity to understand the current economic situation and its industrial implications.” For registration and more info, please visit http://hss.kaist.ac.kr.
2017.04.26
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FinTech Conference by KAIST, EDHEC-Risk Institute, Princeton, and Tsinghua
KAIST will partner with EDHEC-Risk Institute, Princeton University, and Tsinghua University to host a series of annual rotation conference on FinTech. The inaugural conference will be held in Princeton on April 26 and is entitled ‘Four-University Rotating FinTech Conference: Wealth Management Systems for Individual Investors.’ The conference will facilitate discussion among all interest parties of academics, practitioners, and regulators from around the world. Professor Woo Chang Kim of the Department of Industrial & Systems Engineering will represent KAIST. Professor Kim is also the head of the Center for Wealth Management Technologies at KAIST. In addition to Professor Kim, leading experts from the US, Asia, and Europe will present at the conference, including Andrew Yao (Turing Award recipient and founder of IIIS FinTech Center at Tsinghua University), John Bogle (founder of the Vanguard Group, and president of the Bogle Financial Markets Research Center), Lionel Martellini (director of EDHEC-Risk Institute), John Mashey (Bell Labs/Silicon Valley computer scientist/corporate executive), and John Mulvey (professor and founding member of the Bendheim Center for Finance at Princeton University). This year’s conference will feature following sessions: · Mass-Customization of Goal-Based Investment Solutions: The New Frontier in Digital Wealth Management Services · Goal-Based Investment via Multi-Stage Stochastic Goal Programming for Robo-Advisor Services · Big Data – Yesterday, Today and Tomorrow · Applying Machine Learning Concepts for Asset Allocation and ALM · FinTech: Drawing Strengths from Computing Theories · Savings and Investing to Achieve Retirement Goals: An Update Given Current Market Assumptions · The Rise of Robo-Advisors: A Threat or an Opportunity for the Wealth Management Industry? The conference will include the participation of official partner Samsung Asset Management.
2017.04.20
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Professor Otfried Cheong Named as Distinguished Scientist by ACM
Professor Otfried Cheong (Schwarzkopf) of the School of Computing was named as a Distinguished Scientist of 2016 by the Association for Computing Machinery (ACM). The ACM recognized 45 Distinguished Members in the category of Distinguished Scientist, Educator, and Engineer for their individual contributions to the field of computing. Professor Cheong is the sole recipient from a Korean institution. The recipients were selected among the top 10 percent of ACM members with at least 15 years of professional experience and five years of continuous professional membership. He is known as one of the authors of the widely used computational geometry textbook Computational Geometry: Algorithms and Applications and as the developer of Ipe, a vector graphics editor. Professor Cheong joined KAIST in 2005, after earning his doctorate from the Free University of Berlin in 1992. He previously taught at Ultrecht University, Pohang University of Science and Technology, Hong Kong University of Science and Technology, and the Eindhoven University of Technology.
2017.04.17
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Nuclease-Resistant Hybrid Nanoflowers
An eco-friendly method to synthesize DNA-copper nanoflowers with high load efficiencies, low cytotoxicity, and strong resistance against nucleases has been developed by Professor Hyun Gyu Park in the Department of Chemical and Biomolecular Engineering and his collaborators. The research team successfully formed a flower-shaped nanostructure in an eco-friendly condition by using interactions between copper ions and DNA containing amide and amine groups. The resulting nanoflowers exhibit high DNA loading capacities in addition to low cytotoxicity. Flower-shaped nanocrystals called nanoflowers have gained attention for their distinct features of high surface roughness and high surface area to volume ratios. The nanoflowers have been used in many areas including catalysis, electronics, and analytical chemistry. Of late, research breakthroughs were made in the generation of hybrid inorganic-organic nanoflowers containing various enzymes as organic components. The hybridization with inorganic materials greatly enhanced enzymatic activity, stability, and durability compared to the corresponding free enzymes. Generally, the formation of protein nanocrystals requires high heat treatment so it has limitations for achieving the high loading capacities of intact DNA. The research team addressed the issue, focusing on the fact that nucleic acids with well-defined structures and selective recognition properties also contain amide and amine groups in their nucleobases. They proved that flower-like structures could be formed by using nucleic acids as a synthetic template, which paved the way to synthesize the hybrid nanoflowers containing DNA as an organic component in an eco-friendly condition. The team also confirmed that this synthetic method can be universally applied to any DNA sequences containing amide and amine groups. They said their approach is quite unique considering that the majority of previous works focused on the utilization of DNA as a linker to assemble the nanomaterials. They said the method has several advantageous features. First, the ‘green’ synthetic procedure doesn’t involve any toxic chemicals, and shows low cytotoxicity and strong resistance against nucleases. Second, the obtained nanoflowers exhibit exceptionally high DNA loading capacities. Above all, such superior features of hybrid nanoflowers enabled the sensitive detection of various molecules including phenol, hydrogen peroxide, and glucose. DNA-copper nanoflowers showed even higher peroxidase activity than those of protein-copper nanoflowers, which may be due to the larger surface area of the flower- shaped structures, creating a greater chance for applying them in the field of sensing of detection of hydrogen peroxide. The research team expects that their research will create diverse applications in many areas including biosensors and will be further applied into therapeutic applications. Professor Park said, “The inorganic component in the hybrid nanoflowers not only exhibits low cytotoxicity, but also protects the encapsulated DNA from being cleaved by endonuclease enzymes. Using this feature, the nanostructure will be applied into developing gene therapeutic carriers.” This research was co-led by Professor Moon Il Kim at Gachon University and KAIST graduate Ki Soo Park, currently a professor at Konkuk University, is the first author. The research was featured as the front cover article of the Journal of Materials Chemistry B on March 28, Issue 12, published by the Royal Society of Chemistry. The research was funded by the Mid-Career Researcher Support Program of the National Research Foundation of Korea and the Global Frontier Project of the Ministry of Science, ICT & Future Planning. (Figure: (A) Schematic illustration of the formation of nuclease-resistant DNA–inorganic nanoflowers. (B) SEM images showing time-dependent growth of DNA-nanoflowers. The concentration of A-rich ssDNA (Table S1, ESI†) was 0.25 mM.)
2017.04.14
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Expanding the Genetic Code of Mus Musculus
Professor Hee-Sung Park of the Department of Chemistry, who garnered attention for his novel strategy of installing authentic post-translational modifications into recombinant proteins, expanded his research portfolio to another level. Professor Park’s team was the first to report the generation of a mouse strain with an expanded genetic code, allowing site-specific incorporation of unnatural amino acids. Professor Park published the research on the new chemical biology method for achieving selective chemical modifications in proteins in Science last September. The research team, this time in collaboration with Professor Chan Bae Park of the Department of Physiology at the Ajou University School of Medicine, demonstrated temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein as a model protein. This research was published in the online edition of Nature Communications on February 21. This approach enables the rapid onset of position-specific acetylation of a target protein at any developmental stage, facilitating temporal and spatial control of protein acetylation in various organs of the transgenic mouse. Such temporal and spatial control of protein acetylation will be of prime importance for investigating many essential biological processes and human diseases at the tissue and organism level. Almost all human proteins, the products of about 25,000 genes, are known to undergo various post-translational modifications during and after synthesis. Post-translation modifications regulate the function of cellular proteins, playing a key role in many essential processes such as delivering signals and body growth. However, the unusual protein modifications, aroused from genetic and/or environmental factors, trigger severe diseases including cancer, dementia, and diabetes. The team inserted transgenes into the mouse genome to allocate the site-specific addition of unnatural amino acids. The researchers inserted a modified version of lysine into the house mice, which allowed for the control of the acetylation. They used recombinant green fluorescent proteins from transgenic house mice as models for control of the acetylation. The team was also able to regulate the acetylation of specific temporal and spatial frames in the mice, restraining the abnormality in proteins to certain organs such as the liver and kidneys. The research team said the strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organisms for human physiology and disease. Professor Park said, “This method can be easily extended to generate a wide range of custom-made transgenic mouse strains for further investigating diverse proteins of interest.” He added, “This method can be further extended to generate a wide range of custom-made transgenic mouse strains, opening a new paradigm for investigating anti-cancer and cerebral disease treatments. This work was supported by grants from KAIST Systems Healthcare and the Medicinal Bioconvergence Research Center and the Intelligent Synthetic Biology Center of the Global Frontier Project funded by the Ministry of Science, ICT & Future Planning and the Ministry of Food and Drug Safety. (Figure:Temporal and spatial control of in vivo protein acetylation) (a) Temporal expression of acetylated GFPuv in the AcK-GFPamber mouse. The expression of GFPuv in skeletal muscle, liver, and lung tissues was detected only in the AcK-injected mouse. Scale bar, 200 µm. (b) Western blotting of anti-FLAG-immunoprecipitated proteins from tissues of the AcK-GFPamber mouse. Acetylated GFPuv was produced after AcK injection. (c) Spatial expression of acetylated GFPuv in the AcK-GFPamber mouse. Acetylated GFPuv was observed only in skeletal muscle when AcK was directly delivered to the tissues. Sacle bar, 200 µm.
2017.03.27
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Professor Kwangjo Kim Named as Fellow of IACR
Professor Kwangjo Kim of the Graduate School of Information Security has been selected as a fellow of the International Association for Cryptologic Research (IACR). The IACR has honored outstanding scholars who have achieved academic excellence in cryptologic research since 2004. He is the first Korean scholar to receive an IACR fellowship. The IACR, established in 1981, is responsible for organizing international cryptologic conferences every year including the three major cryptologic academic conferences Eurocrypt, Crypto, and Asiacript. The IACR also sponsors workshop series such as the Theory of Cryptography Conference (TCC), the Workshop on Fast Software Encryption (FSE), the Public Key Cryptography Workshop (PKC), and Cryptographic Hardware and Embedded Systems (CHES). Professor Kim, an internationally acclaimed scholar in the fields of cryptology and information security theory and its applications, was recognized for his outstanding academic achievements and leadership. He has made significant contributions to cryptology in Korea by hosting Asiacript in 1996 and 2001 as well as CHES in 2014. During his 34 years of academic activities, he has published more than 80 SCI journal papers and garnered more than 20,000 citations. Professor Kim served on the board of the directors of the IACR from 2000 to 2004 and was the chairperson of the Asiacript Steering Committee from 2005 to 2008. He is on the editorial board of the online journal Cryptography. Professor Kim said, “I am so humbled and honored to be named as a fellow of such a prestigious academic association. I will continue to strive to assist highly educated information security personnel with further research in cryptology.”
2017.03.16
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13 KAIST Faculty Named as Inaugural Members of Y-KAST
The Korean Academy of Science and Technology (KAST) launched the Young Korean Academy of Science and Technology (Y-KAST) and selected 73 scientists as its inaugural members on February 24. Among them, 13 KAIST faculty were recognized as the inaugural members of Y-KAST. Y-KAIST, made up of distinguished mid-career scientists under the age of 45, will take the leading role in international collaboration as well as innovative agenda-making in science and technology. The inaugural members include Professor Hyotcherl Ihee of the Department of Chemistry and Dr. Sung-Jin Oh of the Center for Mathematical Challenges at the Korea Institute for Advanced Study (KIAS), affiliated with KAIST. Professor Ihee is gaining wide acclaim in the fields of physics and chemistry, and in 2016, Dr. Oh was the youngest ever awardee of the Presidential Award of Young Scientist. The other Y-KAIST members are as follows: Professors Haeshin Lee of the Department of Chemistry; Mi Young Kim, Byung-Kwan Cho, and Ji-Joon Song of the Department of Biological Sciences; Song-Yong Kim of the Department of Mechanical Engineering; Sang-il Oum of the Department of Mathematical Sciences; Jung Kyoon Choi of the Department of Bio and Brain Engineering; Seokwoo Jeon, Sang Ouk Kim, and Il-Doo Kim of the Department of Materials Science and Engineering; Jang Wook Choi of the Graduate School of EEWS (Energy, Environment, Water and Sustainability); and Jeong Ho Lee of the Graduate School of Medical Science and Engineering. The leading countries of the Academy of Science, which include Germany, Sweden, Belgium, Canada, and Japan, have established the Young Academy of Science since 2010 in order to encourage the research activities of their young scientists and to establish a global platform for collaborative research projects through their active networking at home and abroad. President Myung-Chul Lee of KAST said, “We will spare no effort to connect these outstanding mid-career researchers for their future collaboration. Their networking will make significant impacts toward their own research activities as well as the global stature of Korea’s science and technology R&D. (Photo caption: Members of Y-KAST pose at the inaugural ceremony of Y-KAST on February 24.)
2017.03.02
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Prof. Woo Chang Kim Is Appointed as Managing Editor of Quantitative Finance
Professor Woo Chang Kim of the Industrial and Systems Engineering Department has been elected as the Managing Editor of Quantitative Finance. Founded in 2001, Quantitative Finance has been an internationally-acclaimed peer-reviewed journal in the field of financial engineering, along with Mathematical Finance. This is the first time for a Korean researcher to be named for the editorial board, which consists of eminent scholars from around the world, including four Nobel laureates. Professor Kim’s expertise lies in financial optimization, portfolio management, and asset liability management. In recent years, he has focused his research on robo-advisors in the area of FinTech, and for this contribution, he was appointed as managing editor. Professor Kim also served as an editor, deputy editor, and a member of the editorial boards for various journals, including the Journal of Portfolio Management and Optimization and Engineering. Currently, he serves as a member of the Korean National Pension Fund’s Electoral Commission, an adviser to Samsung Asset Management Co., Ltd., and the director of the KAIST Asset Management for Future Technology Research Center that was opened in October 2016.
2017.02.23
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