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Nanoparticle Cluster Manufacturing Technique Using DNA Binding Protein Developed
Professor Hak-Sung Kim of the Department of Biological Sciences at KAIST and Yiseul Ryu, a doctoral candidate, used the Zinc Finger protein that specifically binds to target DNA sequence to develop a new manufacturing technique for size-controllable magnetic Nanoparticle Clusters (NPCs). Their research results were published in Angewandte Chemie International Edition online on 25 November 2014.
NPCs are structures consisting of magnetic nanoparticles, gold nanoparticles, and quantum dots, each of which are smaller than 100 nm (10-9m). NPCs have a distinctive property of collectivity not seen in single nanoparticles.
Specifically NPCS differ in physical and optical properties such as Plasmon coupling absorbance, energy transfers between particles, electron transfers, and conductivity. Therefore, NPCs can be employed in biological and medical research as well as the development of nanoelectric and nanoplasmon devices.
To make use of these novel properties, the size and the composition of the cluster must be exquisitely controlled. However, previous techniques relied on chemical binding which required complex steps, making it difficult to control the size and composition of NPCs.
Professor Kim’s team used Zinc Finger, a DNA binding protein, to develop a NPCs manufacturing technique to create clusters of the desired size easily. The Zinc Finger protein contains a zinc ion and specifically recognizes DNA sequence upon binding, which allows the exquisite control of the size and the cluster composition. The technique is also bio-friendly.
Professor Kim’s team created linear structure of different sizes of NPCs using Zinc Finger proteins and three DNA sequences of different lengths. The NPCs they produced confirmed their ability to control the size and structure of the cluster by using different DNA lengths.
The NPCs showed tripled T2 relaxation rates compared to the existing MRI contrast media (Feridex) and effectively transported to targeted cells. The research findings show the potential use of NPCs in biological and medical fields such as MRI contrast media, fluorescence imaging, and drug transport.
The research used the specific binding property of protein and DNA to develop a new method to create an inorganic nanoparticle’s supramolecular assembly. The technique can be used and applied extensively in other nanoparticles for future research in diagnosis, imaging, and drug and gene delivery.
Figure 1. A Mimetic Diagram of NPCs Manufacturing Technique Using DNA Binding Protein Zinc Finger
Figure 2. Transmission Electron Microscopy Images showing different sizes of NPCs depending on the length of the DNA
2014.12.04 View 11925 -
News Article on the Development of Synthesis Process for Graphene Quantum Dots
Before It's News, an international online news agency, highlighted the recent research conducted by KAIST professors (Seokwoo Jeon of the Department of Materials Science and Engineering, Yong-Hoon Cho of the Department of Physics, and Seunghyup Yoo of the Department of Electrical Engineering) on the development of synthesis process for graphene quantum dots, nanometer-sized round semiconductor nanoparticles that are very efficient at emitting photons. If commercialized, this synthetic technology will lead the way to the development of paper-thin displays in the future.
For the article, please go to the link below:
Before It’s News, September 3, 2014“Graphene quantum dots prove highly efficient in emitting light”
http://beforeitsnews.com/science-and-technology/2014/09/graphene-quantum-dots-prove-highly-efficient-in-emitting-light-2718190.html
2014.09.07 View 11690 -
Strawberries Delivered by A Miniature Drone at KAIST Spring Festival
The "HAPPY KAIST 2014 Spring Festival" held at KAIST from 4th April
The Cherry Blossoms Festival under the theme of "Cherry Blossoms: Light and Fantasy" held on 4th April
The Strawberry Party with strawberries exclusively delivered by a miniature drone on 11th April
KAIST is holding a spring festival from April 4th through 11th.
As a part of the "HAPPY KAIST 2014" event, cherry blossoms festival and strawberry party will be held at KAIST campus starting on April 4th.
This event has been organized with the purpose of creating a new culture and tradition for members of KAIST to unite. Faculty members, staff, and students have all contributed to making the festival a success.
The cherry blossoms festival, held under the theme of "Cherry Blossoms: Light and Fantasy," takes place at the road in front of the KAIST north dormitory, which provides a spectacular view of cherry blossom trees. It begins on the night of April 4th and continues until the 8th of April.
Around the cherry blossom tree road displays an art exhibition by the Design Rangers, a student club of graduate and doctorate students from the Department of Industrial Design at KAIST. The exhibition includes the "Fantasy Cherry Blossoms" and "Let’s Walk Together."
Following on the 11th will be the "Strawberry Party" to take place throughout the campus. The strawberry party began in 1995 in order to help the local strawberry farmers. Now, it has become KAIST’s own unique tradition attended by faculty, student clubs, and laboratory members.
This year, the fruit party becomes a unique event in that there will be a demonstration of strawberry delivery by an unmanned vehicle or an unmanned aerial vehicle (a miniature drone).
When a customer orders strawberries via a smart phone application, the user's current location is sent to the central system of an unmanned vehicle. Either the unmanned vehicle (UV) transports strawberries or for places
inaccessible
by the UV such as on a lawn, the drone delivers the fruit to the customer
.
This demonstration has been organized by Professor Hyunchul Shim from the Department of Aerospace Engineering at KAIST. Professor Shim said, “If the unmanned logistics system, such as the one being demonstrated at the Strawberry Party, is commercialized, both cost and time
in the logistics industry
can be significantly reduced.”
The HAPPY KAIST 2014,
organized
by the College of Engineering, is an annual event, consisting of a total of five programs, with the purpose to make the campus happier and
healthier.
2014.04.07 View 9219 -
KAIST Holds the 2014 System on Chip (SoC) Robot War in August and October
Domestic and international competitions for robots with artificial intelligence are organized by Professor Hoi-Jun Yoo of Electrical Engineering.
KAIST will host two robot competitions this year: The Robot Integration Festival will be held in August at the Convention Center in Daejeon and the International Robot Contest in October at the Kintex in Ilsan. Participating robots are developed based on the System on Chip (SoC).
SoC robots refer to an autonomous robot that has a processor, a memory, peripheral devices, logic, and other system components combined on a single chip, which enables the robots to handle tasks and make decisions without human intervention.
The competitions include three entries: Taekwon Robot, HURO-competition, and SoC Drone which was added for the first time this year.
The Taekwon Robot involves a one-on-one sparring match, using a Korean traditional martial art, between two robots. Competitors score points based on front and side kicks, as well as punching. The HURO-competition pits robots in a competition to perform assignments such as hurdling, barricade clearing, crossing bridges, and overcoming other obstacles. The SoC Drone evaluates robots' capability to track miniature cars and navigate between buildings while in flight. The drone should have two cameras and a SoC brainboard equipped to offer autonomous, remote-controlled flight.
The director of the competitions, Professor Hoi-Jun Yoo of Electrical Engineering at KAIST, commented that with the integration of Korea’s world-class semiconductor technology, the competitions would lead to improvements in robotics engineering and unmanned aerial vehicle technology.
The competitions are open to anyone interested in SoC robots and unmanned aerial vehicles. For more information about the competitions, please visit http://www.socrobotwar.org . The application deadline is April 15, 2014.
2014.03.11 View 9758 -
KAIST unveils foldable micro electric car, Armadillo-T
The small and light electric car completely folds in half when parking, making it a perfect fit for public or private transportation in an urban environment.
Looking for a parking space for hours at a busy shopping mall or being stuck on roads jammed with cars releasing large amounts of carbon dioxide are all-too-familiar scenes for city dwellers.
A group of researchers at the Korea Advanced Institute of Science and Technology (KAIST) recently developed a possible solution to such problems: a foldable, compact electric vehicle that can be utilized either as a personal car or part of the public transit system to connect major transportation routes within a city.
In-Soo Suh, associate professor of the Graduate School for Green Transportation at KAIST, and his research team introduced a prototype micro electric car called "Armadillo-T," whose design is based on a native animal of South America, the armadillo, a placental mammal with a leathery armor shell.
The research team imitated the animal"s distinctive protection characteristic of rolling up into a ball when facing with threat from predators. Just as armadillos hide themselves inside the shell, Armadillo-T tucks its rear body away, shrinking its original size of 2.8 meters (110 inches) down to almost half, 1.65 meters (65 inches), when folding.
Armadillo-T is a four-wheel-drive, all-electric car with two seats and four in-wheel motors. Since the motors are installed inside the wheels, and the 13.6 kWh capacity of lithium-ion battery pack is housed on the front side, the battery and motors do not have to change their positions when the car folds. This not only optimizes the energy efficiency but also provides stability and ample room to drivers and passengers.
Once folded, the small and light (weighs 450 kg) electric vehicle takes up only one-third of a 5-meter parking space, the standard parking size in Korea, allowing three of its kind to be parked. With a smartphone-interfaced remote control on the wheels, the vehicle can turn 360 degrees, enhancing drivers" convenience to park the car, even in an odd space in a parking lot, the corner of a building, for example.
Professor In-Soo Suh said, "I expect that people living in cities will eventually shift their preferences from bulky, petro-engine cars to smaller and lighter electric cars. Armadillo-T can be one of the alternatives city drivers can opt for. Particularly, this car is ideal for urban travels, including car-sharing and transit transfer, to offer major transportation links in a city. In addition to the urban application, local near-distance travels such as tourist zones or large buildings can be another example of application."
The concept car has loads of smart features on board, too: the cameras installed inside the car eliminate the need for side mirrors and increase the driver"s ability to see the car"s right and left side, thereby reducing blind spots. With a smartphone, the driver can control Armadillo-T and enable remote folding control. The car has a maximum speed of 60 km/h, and with a ten-minute fast charge, it can run up to 100 km.
Professor Suh explained that the concept of Armadillo-T was originally initiated in 2011 as he focused his research interest on the sub-A segment of personal mobility vehicles (PMVs), which are smaller and lighter than the current compact cars, as a new personalized transport mode.
"In coming years, we will see more mega-size cities established and face more serious environmental problems. Throughout the world, the aging population is rapidly growing as well. To cope with climate, energy, and limited petroleum resources, we really need to think outside the box, once again, to find more convenient and eco-friendly transportation, just as the Ford Model T did in the early 1920s. A further level of R&D, technical standards, and regulatory reviews are required to have these types of micro vehicles or PMVs on the market through test-bed evaluations, but we believe that Armadillo-T is an icon toward the future transport system with technology innovation."
The research project has been supported by the Korean government, the Ministry of Land, Infrastructure and Transport and the Korea Agency for Infrastructure Technology Advancement, since December 2012.Youtube Link: http://www.youtube.com/watch?v=8DoZH7Y-sR0
2013.08.21 View 13955 -
Popular Science May 2013: Online Electric Vehicle (OLEV) Introduced as Part of Smart Roads
Popular Science (PopSci), a famous American monthly magazine publishing popular science articles for general readers on science and technology subjects, introduced KAIST’s Online Electric Vehicle (OLEV) in its latest issue of May 2013. For the article, please see the attachment.
2013.04.25 View 7099 -
KAIST OLEV (On-Line Electric Vehicle) to begin operation!
An On-Line Electric Vehicle (OLEV) that can charge during travel will be put into service for the first time in the world on normal roads.
From July of this year 2 OLEV buses will undergo trial operations in the city of Gumi.
The trial route spans 24km from Gumi station and the region of In-Dong and the establishment of the route is expected to be of a 4.8billion Won scale. The start of the infrastructure construction will start on February and operation will start in July.
KAIST had held sessions in October of last year to local governments and had a follow up OLEV suitability evaluation to those local governments expressing interest.
The city of Gumi was elected due to its good electrical infrastructure and an administrative willingness to match.
The OLEV developed by KAIST is an environmentally friendly vehicle that allows the transfer of electrical power using magnetic fields imbedded in the roads.
Ordinary electric vehicles require frequent visits to replenish their power which gives the OLEV a comparative advantage as it can charge while on the road. The ability to charge whilst on the road means that the OLEV requires a smaller battery than the ordinary electrical vehicle resulting in lower prices and weight.
The OLEV development commenced at KAIST in 2009 and in 2010 most of the core technologies required to realize the OLEV was developed and verified. Finally in 2012 steps were taken that will allow the commercialization of the OLEV.
And in October of last year KAIST OLEV accomplished 75% power transfer efficiency that allowed a system that can be commercialized.
The KAIST OLEV was named top 50 inventions in 2010 by Time Magazine.
2013.01.22 View 10355 -
International Forum on Electric Vehicles 2012
KAIST hosted the International Forum on Electric Vehicles 2012 was held on the 7th of November.
IFEV provided the opportunity for domestic and international front runners of future transportation technology research to come together and discuss the direction and possibility of commercialization of electric vehicles.
The keynote speaker of the forum was Hong Soon Man Director of Korea Railroad Research Institute. Lectures were given by distinguished speakers including Kim Gyung Chul Director of Korea Transportation Research Institute, Takashi Ohira Professor at Toyohashi University of Technology, Tomoyuki Shinkai Professor at Keio University, Christian Kobel Director of Development at Germany’s Bombardier, and Peter Burggraef Professor at Rheinisch University of Technology.
Four topics will be debated on: Future road vehicles and wireless power technology, future high speed railway system, future maritime transportation system, and strategy and policy for green transportation technology.
The IFEV is expected to yield a positive result by allowing government, academia, and industry to come together and discuss the direction of future transportation technology and its social implications.
Detailed information can be found at http://gt.kaist.ac.kr/ifev2012/
2012.11.29 View 7352
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New wireless charging device developed
The On-line Electric Vehicle (OLEV) developed by KAIST has made a step towards commercialization with the development of a more economic wireless charging device.
Professor Chun-Taek Rim from the Department of Nuclear and Quantum Engineering at KAIST has developed a new I-shaped wireless charging device that differs from the pre-existing rail-type electricity feeder. This device can be modularly produced and requires relatively less construction, significantly reducing the cost of implementation.
The KAIST OLEV is a new concept electric car that has a special electricity collecting device underneath it. The car’s battery is charged by magnetic fields produced from electric lines buried 15cm underneath the road. The vehicle was first tested in 2009, making it the first wireless electric car in the world. OLEV can be charged during stoppage time between traffic lights and receives real-time power when running. OLEV is currently in operation at the KAIST Munji Campus in Daejeon and is also being exhibited at the Yeosu Expo and Seoul Grand Park.
The device itself has a charging capacity of 15kW, and the electricity is supplied through an electricity feeder with a width of 80cm with a space interval of 20cm. Despite being hailed as a technological breakthrough and revolutionary concept, KAIST OLEV has been criticized for problems in commercialization, due to the difficulties in installing wires beneath existing roads, which costs a considerable amount of money.
The new I-shaped wireless charging device reduces the width of the electricity feeder by 10cm, a mere one-eighth of the size of the previous version, and greatly increases the charging power to 25kW. Furthermore, the left and right permissible space of automobiles has increased to 24cm and the magnetic field complies with the international design guidelines, making the OLEV safe for the human body.
The reduction of the width has made the mass production of modules possible, making the installation of KAIST OLEV more economical and marketable. Professor Rim emphasized that compared with the existing rail-type electricity feeder, the new technology will need only one-tenth of the construction time and 80% of the cost, significantly improving OLEV’s constructability and workability.
The research was published in the IEEE Transactions on Power Electronics last December, and Professor Rim was invited to talk at the Conference on Electric Roads & Vehicles, which was held in February in the United States, about the new technology.
2012.07.06 View 10800
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The Chronicle of Higher Education: In an Interview, President of Kaist Insists His Reforms Will Continue by David McNeil, December 6, 2011
The Chronicle of Higher Education, based in Washington D.C., is the major news service in the US academic world. The paper published on December 6, 2011 an article on interview with President Nam-Pyo Suh. For the interview, please go to the link at http://chronicle.com/article/Elite-Korean-University-Licks/130020/ or open the attached .pdf file. Thank you.
2011.12.08 View 7573
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New Technology Developed for Analysis of New Drugs by Using Smart Nano-Sensors
Doctor Sang-Kyu Lee
Doctor Sang-Kyu Lee of the Department of Biological Sciences, KAIST, has developed the technology that allows biological nano particles to be implanted into human cells for monitoring the effect of new drugs in real time from within the cell. It is expected that this technology will boost the ability to weigh the effects and properties of a new drug more quickly and accurately.
Conventionally, the candidate drug was injected into the human body, and then its cells are extracted to analyze the effects of the drugs. The problem with this method was that the cells were analyzed at a ‘dead’ state which made it incredibly difficult to find candidate substances due to uncontrollable side effects. This made the development of new drugs very difficult despite the large costs and efforts invested into its development.
The research team latched onto the idea that nanoparticles can connect to form a large complex. The complex acts as a nanosensor which allows for real time observation of drug target and the drug itself binding.
The team named the nanosensor technology ‘InCell SMART-i’ and was named ‘Hot Paper’ of the September edition of ‘Angewandte Chemie International Edition’ magazine, a world famous Chemistry Magazine.When a new drug injected into the human body, the drug and drug targets are gradually combined, and the smart nanosensor detects in real time the effect of the new drug as shown in the pictures above (shaded spot).
2011.09.19 View 9024 -
KAIST Online Electirc Vehicle Introduced by CNN
CNN aired KAIST’s Online Electric Vehicle (OLEV) on August 29, 2011 in its program called “Eco Solutions” that reports on meeting people with innovative solutions to preserve the planet. The reporter went to Seoul Grand Park, an amusement park and introduced an online electric tram developed by KAIST and operated on a daily basis for park visitors since July 29, 2011. KAIST has designed different types of OLEVs including bus, SUV, and tram. The reporter said that “the online electric tram” at the park provides visitors with a “cleaner, greener, and convenience since it charges as you go.” Currently, three OLEVs are running inside the park, and KAIST plans to replace the rest of existing diesel trams with OLEVs in the near future.
CNN Link: http://edition.cnn.com/CNNI/Programs/eco.solutions/index.html
Youtube Link: http://www.youtube.com/watch?v=QLzmFFqPJfo
2011.09.09 View 9790