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More Donations Arrive to Establish the New Medicine Research and Development Center on Campus
A raft of businesses continues to make donations to establish a new medicine research and development center on campus. The Department of Biological Sciences at KAIST is leading the fundraising campaign.
On November 9, 2015, Nikon Instruments Korea Co., Ltd. contributed USD 8,500 to the fundraising, followed by Carl Zeiss AG and Three-Shine Inc., which donated USD 12,800 and 8,500, respectively.
Bruno Lin, an Executive Director at Carl Zeiss AG in Korea, said, “I’m very glad to participate in this fundraising initiative for the Biological Sciences Department at KAIST, one rapidly reaching out to the world.”
From the left in the picture are Vice President Tae-Hoon Kim, Director Gyu-Hyeok Lee, and Executive Director Bruno Lin of Carl Zeiss AG, Byung-Ha Oh, Dean of the Biological Sciences Department, and Professor Eunjoon Kim.
From the left in the picture are Byung-Ha Oh, Dean of the Biological Sciences Department, President Chun-Gui Park of Three-Shine Inc., and Professor Daesoo Kim.
President Chun of Three-Shine Inc., said, “We hope that the Department of Biological Sciences at KAIST, aided by the construction of new research center, will produce practical research achievements and stand on the frontier of new medicine development research in Korea.”
The New Medicine Research and Development Center will be equipped with state-of-the-art, purpose-built research facilities to support convergent, interdisciplinary research in biomedicine.
2015.11.27 View 8216 -
KAIST and Four Science and Technology Universities Host a Start-up Competition
KAIST and four other science and technology universities, such as Gwangju Institute of Science and Technology (GIST), Ulsan National Institute of Science and Technology (UNIST), Daegu Gyeongbuk Institute of Science and Technology (DGIST), and Pohang University of Science and Technology (POSTECH), hosted a startup competition on November 27, 2015 at the Dongdaemun Design Plaza in Seoul.
Approximately 150 participants including students from the five universities, "angel" investors, and entrepreneurs attended the competition.
The competition was held to promote startups that are based on research achievements in science and technology and to foster entrepreneurs with great potential.
Two hundred and sixty applicants from 81 teams competed this year. Only ten teams made it to the finals.
KAIST students presented two business plans: an experience-centered education platform and mobile taxi-pooling service. Students from other universities presented a brain-stimulating simulation software (GIST), handy smart health trainer (GIST), real-time reporting system for luggage (DGIST), a flower delivery system (UNIST), surveillance and alarm system for stock-related events via machinery studies (UNIST), augmented emotion toys using augmented reality (POSTECH), and a nasal spray for fine dust prevention (POSTECH).
KAIST also displayed an exhibition of “wearable haptic device for multimedia contents” and “next generation recommendation service platform based on one-on-one matching system with high expandability and improved user experience system.”
The winning team received an award from the Minister of Science, ICT and Future Planning of Korea, as well as an opportunity to participate in overseas startup programs over the course of ten days.
Joongmyeon Bae, Director of the KAIST Industry and University Cooperation, who organized the contest, said, “The alumni of Stanford University (USA) has annually created over 5.4 million jobs through startup activities. Likewise, we hope that our event will contribute to job creation by fostering innovative entrepreneurs.”
2015.11.26 View 11971 -
Professor Keon-Jae Lee Lectures at IEDM and ISSCC Forums
Professor Keon-Jae Lee of KAIST’s Materials Science and Engineering Department delivered a speech at the 2015 Institute of Electrical and Electronics Engineers (IEEE) International Electron Devices Meeting (IEDM) held on December 7-9, 2015 in Washington, D.C.
He will also present a speech at the 2016 International Solid-State Circuits Conference scheduled on January 31-February 4, 2016 in San Francisco, California.
Both professional gatherings are considered the world’s most renowned forums in electronic devices and semiconductor technology. It is rare for a Korean researcher to be invited to speak at these global conferences.
Professor Lee was recognized for his research on flexible NAND chips. The Korea Times, an English language daily newspaper in Korea, reported on his participation in the forums and his recent work. An excerpt of the article follows below:
“KAIST Professor to Lecture at Renowned Tech Forums”
By Lee Min-hyung, The Korea Times, November 26, 2015
Recently he has focused on delivering technologies for producing flexible materials that can be applied to everyday life. The flexible NAND flash memory chips are expected to be widely used for developing flexible handsets. His latest research also includes flexible light-emitting diodes (LED) for implantable biomedical applications.
Lee is currently running a special laboratory focused on developing new flexible nano-materials. The research group is working to develop what it calls “self-powered flexible electronic systems” using nanomaterials and electronic technology.
Lee’s achievement with flexible NAND chips was published in the October edition of Nano Letters, the renowned U.S.-based scientific journal.
He said that flexible memory chips will be used to develop wearable computers that can be installed anywhere.
2015.11.26 View 12390 -
Using Light to Treat Alzheimer's Disease
Medical application of photoactive chemicals offers a promising therapeutic strategy for neurodegenerative diseases.
A research team jointly led by Professor Chan Beum Park of the Materials Science and Engineering Department at KAIST and Dr. Kwon Yu from the Bionano Center at the Korea Research Institute of Bioscience and Biotechnology (KRIBB) conducted research to suppress an abnormal assembly of beta-amyloids, a protein commonly found in the brain, by using photo-excited porphyrins.
Beta-amyloid plaques are known to cause Alzheimer's disease. This research finding suggests new ways to treat neurodegenerative illnesses including Alzheimer's disease. It was published online as the lead article in the September 21th issue of Angewandte Chemie. The title of the article is “Photo-excited Porphyrins as a Strong Suppressor of ß-Amyloid Aggregation and Synaptic Toxicity.”
Light-induced treatments using organic photosensitizers have advantages to managing the treatment in time and area. In the case of cancer treatments, doctors use photodynamic therapies where a patient is injected with an organic photosensitizer, and a light is shed on the patient’s lesion. However, such therapies had never been employed to treat neurodegenerative diseases.
Alzheimer's starts when a protein called beta-amyloid is created and deposited in a patient’s brain. The abnormally folded protein created this way harms the brain cells by inducing the degradation of brain functions, for example, dementia. If beta-amyloid creation can be suppressed at an early stage, the formation of amyloid deposits will stop. This could prevent Alzheimer’s disease or halt its progress.
The research team effectively prevented the buildup of beta-amyloids by using blue LED lights and a porphyrin inducer, which is a biocompatible organic compound. By absorbing light energy, a photosensitizer such as porphyrin reaches the excitation state. Active oxygen is created as the porphyrin returns to its ground state. The active oxygen oxidizes a beta-amyloid monomer, and by combining with it, disturbs its assembly.
The technique was tested on drosophilae or fruit flies, which were produced to model Alzheimer on invertebrates. The research showed that symptoms of Alzheimer's disease in the fruit flies such as damage on synapse and muscle, neuronal apoptosis, degradation in motility, and decreased longevity were alleviated. Treatments with light provide additional benefits: less medication is needed than other drug treatments, and there are fewer side effects. When developed, photodynamic therapy will be used widely for this reason.
Professor Park said, “This work has significance as it was the first case to use light and photosensitizers to stop deposits of beta-amyloids. We plan to carry the research further by testing compatibility with other organic and inorganic photosensitizers and by changing the subject of photodynamic therapy to vertebrate such as mice.”
Picture 1 – Deposits of Beta-Amyloid in Fruit Flies Stopped by Using Porphyrin and Blue LED Lights
Picture 2 – The Research Finding Published as the Lead Article in Angewandte Chemie (September 2015)
2015.11.11 View 11728 -
Public Lectures by KAIST's Humanities and Social Sciences Research Center
The Humanities and Social Sciences Research Center at KAIST offers public lectures at the International Seminar Hall of the Humanities and Social Sciences building on campus from November 12, 2015 to December 10, 2015. There will be four lectures, all of which will be available in Korean only.
The theme of the lectures is “social issues and strategic solutions.” Experts in various fields including women’s studies, criminal psychology, Go (a Chinese board game) and its philosophy, and Korean studies will participate, offering multifaceted analysis and solutions for social issues in Korea.
Joo-Hee Kim, a researcher at the Korean Women’s Institute of Ewha Women’s University, will lecture on “Problems of Loan Products Exclusively for Women” and discuss the background of "micro-loans" which are often targeted at women, while evaluating the logic of financial corporations behind marketing such products.
Lectures by Professor Ji-Sun Park from the Department of Social Psychology at Ewha Women’s University on “Understanding of Criminal Psychology from Letters,” Professor Soo-Hyun Jeong from the Department of Go at Myeongji University on “Life Lessons and Strategies from Playing Go,” and Professor Seung-Taek Ahn from Kyujanggak Institute for Korean Studies of Seoul National University on “Community Problems in Folk Culture” will follow.
The organizer of the lectures, Professor Jung-Hoon Kim of the Department of Humanities and Social Sciences at KAIST said,
“These lectures will provide local citizens and the KAIST family a wonderful opportunity to understand important social issues from the perspective of social science. It will also serve as a valuable time to think about how our social conflicts could differ from those of other countries, helping us to find solutions.”
To register for these free lectures, go to http://hss.kaist.ac.kr by November 9, 2015.
2015.11.06 View 7484 -
KAIST Hosts the Wearable Computer Contest 2015
“What you see is a compact electronic system on a dust mask, which monitors the amount of dust taken in by a worker and lets other workers know if the person is injured in an industrial site,” said Bum Taek Jung, a Master’s candidate from Sungkyunkwan University during the Wearable Computer Contest 2015 held in KI building of KAIST on November 5, 2015.
He explained his interest in developing this system, “Dust-related respiratory diseases and falling accidents are still prevalent in industrial sites.” He added, “Using the smart dust mask helps monitoring workers’ physical condition in real time, allowing us to cope with accidents in a much more timely manner.” A smart dust mask is a portable device that alerts the user with orange or red light signs when the amount of dust inhaled by the user is higher than the threshold. Its application on a smartphone can also allow project managers to alert the risk of falling accidents to workers by employing a gyroscope and an accelerometer on the mask.
The Wearable Computer Contest 2015 met for the eleventh time at KAIST on November 5-6, 2015. A wearable computer refers to a portable device which users can wear directly on the body or on their clothes while moving. Products that can provide various services by connecting to a smartphone have become increasingly popular. The contest is an excellent opportunity for university students to design creative wearable systems similar to those often depicted in movies and comics.
This year 102 teams from universities all over the nation participated. After screening and evaluation of their presentations, only 8 teams in the product section and 3 teams in the ideas section were selected for the finals. Of the many entries to the contest, the ECG security system caught many people’s attention. The wearable, which attaches to a shirt, acts like an electrocardiogram. By comparing the ECG reading with the one stored in the data server, the wearable can authenticate the user. The system could be widely used by enterprises and financial companies where tight security and authentication are crucial.
The winners of the product and the ideas sections received USD 4,300 and usd 860 respectively along with Minister Prizes from the Minister of Science, ICT and Future Planning of Korea. The Chairman of the contest, Professor Hoi-Jun Yoo from the Electrical Engineering Department of KAIST said, “The contest will be a great opportunity for anyone to have a look at advanced wearable devices developed through close integration of state-of-the-art technologies and creative ideas from young minds.”
2015.11.05 View 8941 -
Partnership with École Centrale Paris
Courtesy of École Centrale Paris News: http://www.ecp.fr/lang/en/home/news?actuID=48892
Strengthening of the partnership betwenn CentraleSupélec and KAIST University, South Korea
The two institutions signed a new agreement.
Hervé Biausser (left in the picture), Director of CentraleSupélec, has met Sung-Mo Steve Kang (right in the picture), the President of the Korea Advanced Institute of Science and Technology (KAIST). They signed an agreement aiming to strengthen the partnership between the two institutions concerning research and higher education.
CentraleSupélec and KAIST have cooperated since 2010 on research projects in the context of the Erasmus Mundus BEAM and EASED programs, which are coordinated by CentraleSupélec.
The next step is now the application of graduate academic mobility in the common fields of excellency of the institutions: energy, electronic, physics and mathematics.
2015.11.02 View 6195 -
KAIST and Hanwha Chemical Agree on Research Collaboration
KAIST signed a memorandum of understanding (MOU) with Hanwha Chemical Co., Ltd., a Korean chemical and auto manufacturer, on November 2, 2015 to establish a research center on campus.
The research center, which will be named “KAIST-Hanwha Chemical Future Technology Research Center,” will implement joint research projects for five years beginning from 2016 to develop innovative, green technologies that will help the Korean chemical industry boost its global competitiveness and to nurture top researchers and engineers in chemical engineering.
The research center will lead the development of next-generation petrochemical materials and manufacturing technology and the establishment of pure high-refining processes which are more energy-efficient and environmentally friendly. KAIST and Hanwha will strive to secure new technologies that have the greatest commercialization potential in the global market. They will also establish a scholarship fund for 15 KAIST doctoral students in the Department of Chemical and Biomolecular Engineering.
Many professors from the Chemical and Biomolecular Engineering Department including Distinguished Professor Sang Yup Lee, who was listed in the Top 20 Translational Researchers of 2014 by Nature Biotechnology this year, and Professor Hyunjoo Lee who received the Woman Scholar award at the 2015 World Chemistry Conference, will work at the research center.
Professor Lee, the head of the research center, said, “Collaborating with Hanwha will give us a strong basis for our efforts to carry out original research and train the best researchers in the field.”
Chang-Bum Kim, the Chief Executive Officer (CEO) of Hanwha Chemical, said,
“We hope our collaborations with KAIST will go beyond the typical industry and university cooperation. The two organizations will indeed jointly operate the research center, and this will become a new model for industry and university cooperation. We expect that the research center will play a crucial role in the development of new products and technologies to grow the Korean chemical industry.”
In the photo, President Steve Kang of KAIST (fourth from left) and CEO Chang-Bum Kim of Hanwha Chemical (fifth from left) hold the MOU together.
2015.11.01 View 12391 -
KAIST Invites Entrepreneurs and Experts to Participate in a Social Technology Innovation Symposium
The Research Institute for Social Technology and Innovation (RISTI) at KAIST hosted the Social Technology Innovation Symposium on November 4, 2015 in KI building, to which 100 social business entrepreneurs and experts in the field were invited.
Social businesses refer to activities of companies, which strive to resolve social problems such as environmental issues, income inequality, and aging societies while seeking profit at the same time. This is different from companies taking social responsibility and non-profit organization serving the community in that they attempt to solve social problems through a sustainable business model.
Held under the theme of “technology capabilities of companies and social business strategies,” this symposium was the first to gather representatives from social venture companies, medium-sized enterprises, and major companies at one place to share their experiences in a social business and to discuss future tasks.
The symposium was divided into sessions with three different topics ranging from social business strategies using information technology, a social business and its business model, and social business strategies of major companies.
The symposium started with keynote speeches delivered by Professor HongKyu Lee, RISTI, and Professor Hong-Tak Lim, RISTI, who discussed the role of technology in a social business. It was followed by plenary sessions led by CEOs who are running social businesses such as the Sharing and Technologies Incorporated Project, Simwon Technology, Ecojun Company, Underdogs, and the Farming Fund as well as by representatives from a social responsibility section of CJ management team and the social responsibility council of SK. In the future, these talks will serve as a medium to share their experiences in social businesses and to discuss the role of technology in the business. Some talks touched upon topics such as development of platforms for social innovation, social businesses employing disabled workers, and crowd funding for farming.
The Director of RISTI, Professor HongKyu Lee said, “The symposium will be the first to have people from leading companies in social businesses in Korea in one place.” He added, “This will be a great opportunity for anyone to know what will be the future of social businesses, which were created to solve the social problems caused by capitalism.”
The symposium was sponsored by the Ministry of Trade, Industry, and Energy of Korea.
2015.10.30 View 9489 -
KAIST's Graduate School of Culture Technology Celebrates Its Tenth Anniversary
The Graduate School of Culture Technology (GSCT) at KAIST hosted a ceremony and a variety of events to celebrate its tenth anniversary on October 22, 2015, on campus.
Established in 2005 with the support of the Ministry of Culture, Sports and Tourism of the Republic of Korea, GSCT offers an intensive, in-depth education in culture technology, an interdisciplinary field first introduced in Korea by KAIST, which brings arts, humanities, science, and technology together in an academic and research arena.
Over the years, the graduate school has fostered top-notch researchers and professionals who have played a leading role in the development of a Korean culture contents industry that includes movies, broadcasting programs, music, games, and culture events.
After the anniversary ceremony, GSCT held a "Demo Day" to showcase its major research projects. A total of 41 projects were presented under the themes of “Art and Science,” “Human and Humane,” and “Virtual Reality vs Reality.”
In addition, there was a seminar held on GSTC’s ten-year accomplishment and future planning with the school’s Professors Sunghee Lee, Juyong Park, and Juhan Nam; a cultural event for the public called the “Talk Concert,” which included many professionals in culture industry and academia to share ideas and views; and the Homecoming Day for GSTC graduates. So far, the graduate school has produced 295 masters and 34 doctors. About 34% of its graduates are employed in the movie, game, and broadcasting sectors, 33% in the social networking service and Internet industry, and 33% in performing art and exhibition and event.
Dong-Man Lee, the Dean of KAIST's Graduate School of Culture Technology, said,
“We will continue to develop our school to lead the advancement of the Korean culture industry, contributing to the growth of Korean Wave, the popularity of Korean culture, in the global community.”
In the picture below, Dean Lee delivers a speech to celebrate the school’s tenth anniversary.
Soo-Man Lee, the founding chairman of S.M. Entertainment, speaks at the Talk Concert.
Scenes from the Demo Day
2015.10.26 View 8788 -
Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award.
Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years.
Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years.
Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells.
Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23 View 12895 -
Establishment of System Metabolic Engineering Strategies
Although conventional petrochemical processes have generated chemicals and materials which have been useful to mankind, they have also triggered a variety of environmental problems including climate change and relied too much on nonrenewable natural resources. To ameliorate this, researchers have actively pursued the development of industrial microbial strains around the globe in order to overproduce industrially useful chemicals and materials from microbes using renewable biomass. This discipline is called metabolic engineering.
Thanks to advances in genetic engineering and our knowledge of cellular metabolism, conventional metabolic engineering efforts have succeeded to a certain extent in developing microbial strains that overproduce bioproducts at an industrial level. However, many metabolic engineering projects launched in academic labs do not reach commercial markets due to a failure to fully integrate industrial bioprocesses.
In response to this, Distinguished Professor Sang Yup Lee and Dr. Hyun Uk Kim, both from the Department of Chemical and Biomolecular Engineering at KAIST, have recently suggested ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. Systems metabolic engineering differs from conventional metabolic engineering by incorporating traditional metabolic engineering approaches along with tools of other fields, such as systems biology, synthetic biology, and molecular evolution.
The ten strategies of systems metabolic engineering have been featured in Nature Biotechnology released online in October 2015, which is entitled "Systems strategies for developing industrial microbial strains."
The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects. Specifically, they consist of: 1) project design including economic evaluation of a target bioproduct; 2) selection of host strains to be used for overproduction of a bioproduct; 3) metabolic pathway reconstruction for bioproducts that are not naturally produced in the selected host strains; 4) increasing tolerance of a host strain against the bioproduct; 5) removing negative regulatory circuits in the microbial host limiting overproduction of a bioproduct; 6) rerouting intracellular fluxes to optimize cofactor and precursor availability necessary for the bioproduct formation; 7) diagnosing and optimizing metabolic fluxes towards product formation; 8) diagnosis and optimization of microbial culture conditions including carbon sources; 9) system-wide gene manipulation to further increase the host strain's production performance using high-throughput genome-scale engineering and computational tools; and 10) scale-up fermentation of the developed strain and diagnosis for the reproducibility of the strain's production performance.
These ten strategies were articulated with successful examples of the production of L-arginine using Corynebacterium glutamicum, 1,4-butanediol using Escherichia coli, and L-lysine and bio-nylon using C. glutamicum.
Professor Sang Yup Lee said, "At the moment, the chance of commercializing microbial strains developed in academic labs is very low. The strategies of systems metabolic engineering outlined in this analysis can serve as guidelines when developing industrial microbial strains. We hope that these strategies contribute to improving opportunities to commercialize microbial strains developed in academic labs with drastically reduced costs and efforts, and that a large fraction of petroleum-based processes will be replaced with sustainable bioprocesses."
Lee S. Y. & Kim, H. U. Systems Strategies for Developing Industrial Microbial Strains. Nature Biotechnology (2015).
This work was supported by the Technology Development Program to Solve Climate Change on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556) and by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) from the Ministry of Science, ICT and Future Planning (MSIP), Korea, and through the National Research Foundation (NRF) of Korea. This work was also supported by the Novo Nordisk Foundation.
Picture: Concept of the Systems Metabolic Engineering Framework
(a) Three major bioprocess stages (b) Considerations in systems metabolic engineering to optimize the whole bioprocess. List of considerations for the strain development and fermentation contribute to improving microbial strain's production performance (red), whereas those for the separation and purification help in reducing overall operation costs by facilitating the downstream process (blue). Some of the considerations can be repeated in the course of systems metabolic engineering.
2015.10.19 View 11416