ANG
-
The thermal fluctuation and elasticity of cell membranes, lipid vesicles, interacting with pore-forming peptides were reported by a research team at KAIST.
A research team from KAIST, consisted of Sung-Min Choi, Professor of Nuclear and Quantum Engineering Department, and Ji-Hwan Lee, a doctoral student in the Department, published a paper on the “thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides.” The paper was carried by Physical Review Letters, an internationally renowned peer-review journal on physics on July 16, 2010.
Cell membranes, which consist of lipid bilayers, play important roles in cells as barriers to maintain concentrations and matrices to host membrane proteins. During cellular processes such as cell fission and fusion, the cell membranes undergo various morphological changes governed by the interplay between protein and lipid membranes. There have been many theoretical and experimental approaches to understand cellular processes driven by protein-lipid membrane interactions. However, it is not fully established how the membrane elastic properties, which play an important role in membrane deformation, are affected by the protein-membrane interactions.
Antimicrobial peptides are one of the most common examples of proteins that modify membrane morphology. While the pore-forming mechanisms of antimicrobial peptides in lipid bilayers have been widely investigated, there have been only a few attempts to understand the mechanisms in terms of membrane elastic properties. In particular, the effects of pore formation on the membrane fluctuation and elastic properties, which provide key information to understand the mechanism of antimicrobial peptide activity, have not been reported yet. The research team reports the thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides, which were measured by neutron spin-echo spectroscopy.
The results of this study are expected to pay an important role in understanding the elastic behavior and morphological changes of cell membranes induced by protein-membrane interactions, and may provide new insights for developing new theoretical models for membrane fluctuations which include the membrane mediated interaction between protein patches.
(a) (b)
Figure
(a) Schematics for bound melittin and pores in lipid bilayers
(b) P NMR signal ratio (with/without Mn2+) of DOPC LUV-melittin vs P/L at 30˚C. The dashed line is a guide for eyes.
2010.07.23 View 11218 -
International Center was built to promote greater exchanges and collaborations between the international community and KAIST.
On July 9, 2010, KAIST held an opening ceremony for the construction of International Center. The Center will serve as an internal and external liaison for the university, providing a source of assistance to faculty, administrators, and students on matters related to international activities and initiatives. It will also pursue greater exchanges and collaborations between the international community and KAIST.
The facility accommodates various meetings, exhibitions, library, language services, and other amenities. The International Cooperation Team of KAIST will be moved into this building and provide a variety of services, such as immigration regulations, cultural adjustment, employment, to assist international students, scholars, faculty, and staff at KAIST, as well as Korean students seeking opportunities to study, work, or travel abroad. An international nursery school will also be inside the building so that foreign faculty and students with children can have convenience and quality child care while they are teaching or studying.
At the center will be held many different kinds of international event—one among them is KAIST-ONE, a festival held twice a year in spring and fall to introduce and share culture, education, and food of the global community at KAIST.
2010.07.19 View 10821 -
A senior couple donated their fortune to KAIST, hoping their contribution to be used for the development of science and technology in Korea.
A couple living in Kyunggi Province, Chun-Sik Cho (86) and Chang-Gi Yoon (82), donated to KAIST a 10 billion won worth of real estate. The couple thought about giving away their fortune since retirement and finally made up their mind after becoming to know about their neighbor’s good deeds.
The neighbor, Byung-Ho Kim, gave KAIST a 30 billion won worth of real estate last year. Influenced by Mr. Kim’s donation and their long-cherished wish to help others in need, the couple decided to transfer the ownership of their land to KAIST. They hoped that their contribution to be used for the development of science and technology in Korea.
The couple, who survived through the Korean civil war in the early 1950s, recalled their old days,
“We made through a harsh and difficult life right after the war. Everyone was poor and had nothing to wear or eat. We literally had to eat all sorts of grasses that were green on the ground. All of us had to work really hard to get out of despair resulted from the colonization of our nation by Japan and the subsequent civil war.”
Mr. Cho added, “The development of science and technology in our nation really propelled the overall advancement of our society and helped to make today’s success that is enjoyed by the current generation of our nation. It is our greatest hope that our contribution will add a small help in our nation’s efforts to further advance the development of science and technology. I would like KAIST to do just that with our donation.”
KAIST announced a plan to use their contribution for the establishment of a new graduate school specialized in green transportation and the development of related technology, called Green Transportation Graduate School. The university will name the new graduate school after the couple’s name in recognition of their goodwill.
The Green Transportation Graduate School will host academic programs and conduct researches related to the future transportation that is based on a renewable energy source and provides answers to the current energy problems faced by mankind. Multidisciplinary and convergent studies will be implemented through collaborations between academia, governments, and industries.
In the past four years, KAIST has witnessed a dramatic increase in the number and amount of donations received from all corners of Korean society and from around the world since President Nam Pyo Suh took the university’s top administrative office in 2006—1,004 in 2006; 2,158 in 2007; 3,091 in 2008; and 3,324 in 2009.
Major contributions since 2006
30 billion Won by Moon-Sul Chung in July 2001
10 million USD by Byiung-Joon Park in September 2007
2.5 million USD by Neil Pappalardo in November 2007
57.8 billion Won by Geun-Chul Ryu in August 2008
30 billion Won by Byung-Ho Kim in August 2009
2010.07.07 View 10992 -
The 8th International Conference on Metabolic Engineering was held on June 13-18, 2010 in Jeju Island, South Korea.
From left to right, top row: Distinguished Professor and the conference chair Sang Yup Lee, Sang-Hyup Kim - Secretary to the President of Korea, Dr. Jay Keasling, Dr. Greg Stephanopoulos. Left to right, bottom row: Dr. William Provine, Dr. Terry Papoutsakis, Dr, Jens Nielsen, Dr. Lars Nielsen.
The importance of industrial biotechnology that produces chemicals and materials from renewable biomass is increasing due to climate change and the dearth of natural resources. Industrial biotechnology refers to a technology that allows sustainable bio-based production of chemicals and materials that could enrich human"s lives using microorganisms. This is where metabolic engineering comes into play for successful application of microorganisms, in which they are engineered in our intended way for improved production capability.
The 8th International Conference on Metabolic Engineering, the longest running conference of its kind, was held on June 13-18, 2010 at the International Convention Center in Jeju Island, South Korea. Distinguished Professor Sang Yup Lee of KAIST, Dean of College of Life Science and Bioengineering and Co-Director of Institute for the BioCentury, chaired the conference with the main theme of "metabolic engineering for green growth."
With 300 delegates selected by the committee, papers on production of biofuels, chemicals, biopolymers, and pharmaceutics and the development of fundamental metabolic engineering techniques were presented at the conference along with examples of successful commercialization of products developed by several global companies.
Sang Hyup Kim, Secretary to the President of Korea, gave an opening plenary lecture entitled "Korean green growth initiative," to inform experts from around the globe of the leadership on green growth in Korea. Young Hoon Park, President of Korea Research Institute of Bioscience and Biotechnology (KRIBB, Korea) delivered his congratulatory address.
Sang Hyup Kim said, "Hosting an international conference in Korea on metabolic engineering, which forms a core technology necessary for the development of environmentally friendly processes for producing chemicals and biofuels from renewable biomass, is very meaningful as green growth is a big issue around the globe. This is a great chance to show the excellence of Korea"s green growth associated technology to experts in metabolic engineering and industrial biotechnology."
A total of 47 invited lectures in this conference included recent and important topics, for instance, "Synthetic biology for synthetic fuels" by Dr. Jay Keasling from the Joint BioEnergy Institute (USA), "Microbial oil production from renewable feedstocks" by Dr. Greg Stephanopoulos from MIT (USA), "Yeast as a platform cell factory for production of fuels and chemicals" by Dr. Jens Nielsen from Chalmers University (Sweden), "Mammalian synthetic biology - from tools to therapies" by Dr. Martin Fussengger from ETH (Switzerland), "Building, modeling, and applications of metabolic and transcriptional regulatory networks at a genome-scale" by Dr. Bernhard Palsson from the University of California - San Diego (USA), "Genome analysis and engineering Eschericha coli for sucrose utilization" by Dr. Lars Nielsen from the University of Queensland (Australia), "Artificial microorganisms by synthetic biology" by Dr. Daniel Gibson from JCVI (USA), and "Metabolomics and its applications" by Dr. Masaru Tomita from Keio University (Japan). From Korea, Dr. Jin Hwan Park from the research group of Dr. Sang Yup Lee at KAIST presented "Systems metabolic engineering of Escherichia coli for amino acid production," and Dr. Ji Hyun Kim from KRIBB presented "Genome sequencing and omics systems analysis of the protein cell factory of Escherichia coli".
Global companies involved in biorefinery presented their recent research outcomes with emphasis on commercialized technologies. They included "Metabolic and process engineering for commercial outcomes" by Dr. William Provine from DuPont (USA), "Direct production of 1,4-butanediol from renewable feedstocks" by Dr. Mark Burk from Genomatica (USA), "Development of an economically sustainable bioprocess for the production of bio 1,2-propanediol" by Dr. Francis Voelker from Metabolic Explorer (France), "Biotechnology to the bottom-line: low pH lactic acid production at industrial scale" by Dr. Pirkko Suominen from Cargill (USA), "Bioisoprene™: traditional monomer, traditional chemistry, sustainable source" by Dr. Gregg Whited from Danisco (USA) and "Efficient production of pharmaceuticals by engineered fungi" by Dr. Roel Bovenberg from DSM (Netherlands).
This biennial conference also presented the International Metabolic Engineering Award (expanded version of the previous Merck Metabolic Engineering Award) to the best metabolic engineer in the world. The 2010 International Metabolic Engineering Award went to Dr. E. Terry Papoutsakis from the University of Delaware (USA) who has contributed to the production of biobutanol through the metabolic engineering of Clostridia in the last three decades, and he gave an award lecture. Dr. Sang Yup Lee, the current chair of the upcoming conference, was the previous recipient of this award at the last metabolic engineering conference in 2008.
In addition to the invited lectures, a total of 156 carefully selected poster papers were chosen for presentation, and awards were presented to the best posters after rigorous review by the committee members. Such awards included "The 2010 Metabolic Engineering Best Poster Award" and the "2010 Young Metabolic Engineer Award" from the Metabolic Engineering conference, and prestigious international journal awards, including "Wiley Biotechnology Journal Best Poster Award", "Wiley Biotechnology and Bioengineering Best Poster Award" and "Elsevier Metabolic Engineering Best Paper Award." Dr. Catherine Goodman, a senior editor of Nature Chemical Biology, also presented the "Nature Chemical Biology Best Poster Award on Metabolic Engineering."
Regarding this conference, Dr. Sang Yup Lee, the conference chair, said, "This conference is the best international conference in the field of metabolic engineering, which is held every two years, and Korea is the first Asian country to host it. All the experts and students spend time together from early breakfast to late poster sessions, which is a distinct feature of this conference. Although the number of delegates had typically been limited to 200, around 300 delegates were selected this year to accept more attendees from many people who have been interested in metabolic engineering. Also, it is very fitting that "green growth" is the main topic of this conference because Korea is playing a key role in this field. I"m grateful to the Lotte Scholarship Foundation, COFCO, GS Caltex, Bioneer, US DOE, US NSF, Daesang, CJ Cheiljedang, Genomatica and DuPont who provided us with generous financial support that allowed the successful organization of this conference."
The conference was organized by the Systems Biology Research Project Team supported by the Ministry of Eduction, Science and Technology (MEST), Microbial Frontier Research Project Group, World Class University Project Group at KAIST, Institute for the BioCentury at KAIST, Korean Society for Biotechnology and Bioengineering, and the Engineering Conference International (ECI) of the United States.
Inquiries: Professor Sang Yup Lee (+82-42-350-3930), industrialbio@gmail.com
2010.06.25 View 17830 -
Master of Science in Intellectual Property: First Class Starts on Saturday, February 6, 2010
Newly Established, Postgraduate Course for Master of Science in Intellectual Property
First class starts on February 6th, 2010
In conjunction with Korean Intellectual Property Office (KIPO), KAIST has established a new postgraduate course for a master of science in intellectual property (IP). 41 students have enrolled the course, and its first class will begin February 6th, 2010. With a diverse professional background, the first-year students came from private businesses, IP service industry, and public organizations.
Globally well-known companies—Samsung Electronics, LG Electronics, and the Pohang Iron and Steel Company (POSCO)—and mid-sized companies have offered scholarships to support the new M.S. Program. Business and industry in Korea have recognized the increasingly important role of intellectual property in a modern economy and showed a strong interest in developing workforce specialized in subjects such as, but not limited to, patent law, copyright and designs law, trade mark law, unfair competition, anti-trust law, competition law, and trade secret law.
Prosecutor Chan-Gi Na from Seoul Central District Prosecutor’s Office said, “I’ve applied for the master program at KAIST because I wanted to learn more about intellectual property in greater depth. Through the coursework, I hope to enhance my knowledge on the subjects and use it for the protection of Koreans’ IP related rights and the development of our nation’s IP industry.”
Assistant Manager Jin-Hong Bae from Samsung Securities, Inc. said, “Since the capital market law becomes effective, the need for developing new financial products or services in our finance market has rapidly grown. We no longer can make our financial products by simply copying or ripping off ideas from others. It’s a must practice, not an option, to set up a system under which we are able to protect our IPs.”
“I would like to become an expert in our finance market, who really knows how to commercialize intellectual property assets into benefits, so any know-hows or ideas accumulated from years of working in the field can be registered and protected,” added Mr. Bae.
KAIST’s Mater Program for intellectual property is designed for engineers who wish to acquire the skills required to play a leading role in the field. These engineers, KAIST anticipates, will establish and execute business strategies to protect intellectual property, generate added values for a company, and effectively respond against patent related claims.
The intellectual property will seize up to 90% of business values to be generated in the 21st century. KAIST has long foreseen the need for training top-notch engineers in intellectual property. Combined with multidisciplinary approach to engineering, law, and management, the new M.S. Program will provide students with a variety form of classes to assist them in getting a practical knowledge as needed based on their interests and career aspirations. Examples of the classes are workshops on the change in technology trends—i.e., information technology (IT), environmental technology (ET), and bio technology (BT); standardization of intellectual property and value assessment; and patent law related claims.
“All professors involved in the course are experts who are equipped with hands-on experiences in working on intellectual property for a long time at government agencies, companies, and law firms,” Professor Chul-Ho Kim, responsible for overseeing the entire program, said.
He also expressed his confidence that “We have set up an academic system to induct highly qualified professionals and engineers, capable of handling all aspects of intellectual property related issues, into work places. Our coursework encompasses technology, research and development (R&D), and management, and students who complete the program will be ready to tackle down any intellectual property matters in the 21st century.”
Freshmen convocation for the IP M.S. Program is scheduled on February 20th at KAIST, and President Nam Pyo Suh and Commissioner Jung-Sik Koh of Korean Intellectual Property (KIPO) will attend the event.
2010.02.04 View 12730 -
KAIST to Join Forces with Northwestern School of Law in MIP Program
KAIST has agreed to collaborate in its Master of Intellectual Property (MIP) program with Northwestern University School of Law, the university authorities said on Wednesday (Nov. 11).
KAIST President Nam-Pyo Suh and Northwestern Univ. School of Law Dean David Van Zandt signed a memorandum of understanding for the establishment of the certificate and degree programs of the Anglo-American law in February 2010, at the president"s office Wednesday.
The latest agreement represents an expansion of the existing KAIST-Northwestern Executive LLM program that the two schools have successfully operated for the past eight years. It is aimed at boosting KAIST"s global intellectual property capabilities at a time when the strategic management of intellectual properties and capabilities to deal with international intellectual property disputes are gaining growing importance.
The newly-established two-year, six-semester program is designed to offer a certificate program in the Anglo-American and intellectual property laws to make students better armed with legal knowledge in a competitive global environment.
Northwestern University School of Law is regarded as one of the top law schools in the United States. American law schools are better positioned than any other institutions to prepare students to move from domestic to international practice in today"s complex global economy.
LLM is Latin for Legum Magister, signifying Master of Laws
. course and neto ba ... signing an agreement to run a joint masters degree program at the KAIST campus in Seou
2009.11.19 View 11976 -
Prof. Woo's Team Discovers Eco-Friendly Solid-Oxide Fuel Cell System
A KAIST research team led by Prof. Seong-Ihl Woo of the Department of Chemical & Biomolecular Engineering has found a method to use glycerol, a byproduct from the production of biodiesel, as fuel for solid oxide fuel cells (SOFC), university authorities said on Tuesday (Oct. 27).
The research finding shows that glycerol can be an environmentally sustainable fuel when it is used for operating SOFCs with internal reforming, instead of hydrogen and methane. The finding was published in the Oct. 14, 2009 online edition of ChemSusChem, a sister journal of Angewandte Chemie, the world"s leading chemistry journal.
Biodiesel is an attractive alternative energy source because of its low sulfur content and demand is growing worldwide as oil price soars. Bio-derived glycerol will not contribute to the greenhouse effect and has the potential to contribute to reducing global warming.
Currently, glycereol is used as a raw material in the cosmetic, pharmacy, food, and tobacco industries. However, its supply exceeds its demand as the volume of biodiesel production increases. The production of 1 ton of biodiesel produces 0.1 ton of glycerol. Many researchers have investigated various routes for the consumption of surplus glycerol.
The research is expected to contribute to sustainable growth by reducing the emissions of carbon dioxide and reusing generated carbon dioxide for the production of biomass. The new method enables manufacturers to use glycerol as a fuel for operating SOFC.
2009.10.28 View 12301 -
KAIST's Industrial Design Program Rated among World's Best
KAIST"s master"s program in the area of industrial design has been rated among the world"s best in the latest survey of the World"s Best Design Programs published in the Oct. 2, 2009 issue of BusinessWeek, university authorities said Wednesday, Oct. 7.
The magazine has selected 30 top design programs at the postgraduate level from all over the world. Only six programs in Asia -- one each in Korea, Japan, China, Hong Kong, Taiwan and India -- were included in the list, while famous design schools in the United States and Europe dominated the list.
Why was KAIST on the list? The magazine commented: "The master"s program, set up in 1991, focuses on human-centered design, technology convergence, and business innovation. Students take courses in design marketing and design management to understand wider corporate issues and also learn how to use design as a strategic tool."
In presenting the list of top design programs, the magazine said that "students in these programs take classes in art, management and science, for example, and create projects in multi-disciplinary teams with students from other schools, They aim to use design for strategy rather than merely for aesthetics and may find jobs as design managers, researchers or business consultants." The magazine concluded that "these programs have formally established hybrid curricula."
Meanwhile, Woo-sung Park, a KAIST graduate, has been chosen among the "Twenty-one People Who Will Change Business" surveyed by the magazine. After graduating with a B.S. in industrial design from KAIST in 2005, Park worked for a design firm for two years. He then returned to KAIST to develop the analytical skills he now uses at the global consultancy Boston Consulting Group in Seoul.
2009.10.09 View 10547
-
KAIST Secures Top Ranking of Korean Universities
KAIST won the No. 1 position for the second year in a row in the daily JoongAng Ilbo"s university rankings for 2009. Seoul National University took back the No. 2 spot, followed in order by POSTECH, Korea and Yonsei universities.
The survey was conducted in the four categories, educational environment/finance, professors" research, general reputation/social advancement and globalization. KAIST scored 293 points out of possible 400 this year, while the second-ranking SNU and third-ranking POSTECH earned 234 and 226 points, respectively.
The daily noted that KAIST particularly excelled in the category of educational environment/finance. It observed that donations to KAIST surged almost 100 times for the past three years since 2006 when President Suh took office.
In specific rankings of universities by academic disciplines, SNU came in first overall. KAIST topped in the science and engineering field, while Korea University ranked first in liberal arts studies.
This year, 88 four-year universities participated in the survey. The daily JoongAng Ilbo started its annual evaluation of Koran universities in 1994 to stimulate productive competition among institutions of higher learning and to provide objective standards for students and their parents to select schools for application.
For more information, news.joins.com/article/391/3789391.html
2009.09.24 View 13640
-
KAIST Undergraduates Open Four-Day International Conference
The ICISTS-KAIST, an annual international conference organized by KAIST undergraduate students, opened on Thursday (Aug. 20) at the KAIST"s main campus in Daejeon.
The 2009 ICISTS (International Conference for the Integration of Science and Technology into Society) drew around 200 experts and students from 44 countries. Since its inception in 2005 to promote discourse on important science and technology issues affecting modern society, the conference has served as an opportunity for academic networking among students in various parts of the world.
The four-day conference consists of lectures, open discussions among lecturers and students, field trips to help students to understand actual applications, and team projects.
This year"s conference offers three workshops under the themes of "Climate Change: Merging Technology and Policy for Green Solutions"; "Human-Computer Interaction: Designing Computer System for Intuitive Human Access"; and "Nano Clinic: Breakthrough in Conquering Disease."
Lectures by invited experts in various scientific fields will help broaden students" perspectives particularly from interdisciplinary viewpoints, said an organizer of the conference.
2009.08.28 View 13563
-
KAIST College of Life Sciences and Bioengineering Signs MOU with Harvard
KAIST’s College of Life Sciences and Bioengineering recently signed a memorandum of understanding (MOU) with Harvard University’s Center for Brain Science on July 20, which will allow for joint research and exchange in researchers between the two institutions.
Headed by Director Kenneth Blum, Harvard’s Center for Brain Science leads the world in brain-related research. The new MOU will allow for research cooperation, exchanges of professors, researchers, and students, joint usage of infrastructure and research materials, and finally, sharing of research assignments.
The Dean of the College of Life Sciences and Bioengineering Sang Yup Lee, who concerted efforts to form the MOU said, “This agreement will bring together two of the world’s leading brain-related research teams, and I hope that combining their expertise will bring great advances in brain science and engineering.
KAIST’s College of Life Science and Bioengineering, which is known for its creative interdisciplinary research, is producing exemplary research results in the field of brain science from its Biological Sciences and Bio and Brain Engineering departments.
In addition to cooperation with Harvard, KAIST has also formed partnerships with Emory University, Japan’s RIKEN Brain Institute, and Germany’s Max Planck Institute. Not only does it have a worldwide network pertaining to brain research, but KAIST has also engaged in cooperative research with prominent domestic institutions such as, Asan Medical Center, the Korea Research Institute of Bioscience and Biotechnology, the Korea Research Institute of Standards and Science, and the SK Corporation. Through these connections, KAIST has managed to lead in mutually cooperative brain interdisciplinary research.
2009.08.10 View 14590
-
Prof. Sang-Ouk Kim Featured on the Cover of Emerging Investigator Special Issue
KAIST Prof. Sang-Ouk Kim of the Department of Materials Science and Engineering was featured on the cover of the Emerging Investigator Special Issue published by Britain"s Royal Society of Chemistry on June 21, university authorities said on Monday (June 22).
The special issue shed spotlight on 18 up-and-coming scientists who have been selected through the recommendation and rigorous screening process of the editorial and advisory boards of the Royal Society of Chemistry. The 18 scientists consist of six from the American continent, 10 from Europe, one from Japan and one from Korea.
The journal introduced Prof. Kim"s paper, titled "Highly entangled carbon nanotube (CNT) scaffolds by self-organized aqueous droplets." Kim explained in the paper that the cellular CNT demonstrated high electrical conductivity and field-emission properties, which is potentially useful for various applications in electronics and energy storage devices.
2009.06.24 View 12028