CO
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Ultrathin but Fully Packaged High-Resolution Camera
- Biologically inspired ultrathin arrayed camera captures super-resolution images. -
The unique structures of biological vision systems in nature inspired scientists to design ultracompact imaging systems. A research group led by Professor Ki-Hun Jeong have made an ultracompact camera that captures high-contrast and high-resolution images. Fully packaged with micro-optical elements such as inverted micro-lenses, multilayered pinhole arrays, and gap spacers on the image sensor, the camera boasts a total track length of 740 μm and a field of view of 73°.
Inspired by the eye structures of the paper wasp species Xenos peckii, the research team completely suppressed optical noise between micro-lenses while reducing camera thickness. The camera has successfully demonstrated high-contrast clear array images acquired from tiny micro lenses. To further enhance the image quality of the captured image, the team combined the arrayed images into one image through super-resolution imaging.
An insect’s compound eye has superior visual characteristics, such as a wide viewing angle, high motion sensitivity, and a large depth of field while maintaining a small volume of visual structure with a small focal length. Among them, the eyes of Xenos peckii and an endoparasite found on paper wasps have hundreds of photoreceptors in a single lens unlike conventional compound eyes. In particular, the eye structures of an adult Xenos peckii exhibit hundreds of photoreceptors on an individual eyelet and offer engineering inspiration for ultrathin cameras or imaging applications because they have higher visual acuity than other compound eyes.
For instance, Xenos peckii’s eye-inspired cameras provide a 50 times higher spatial resolution than those based on arthropod eyes. In addition, the effective image resolution of the Xenos peckii’s eye can be further improved using the image overlaps between neighboring eyelets. This unique structure offers higher visual resolution than other insect eyes.
The team achieved high-contrast and super-resolution imaging through a novel arrayed design of micro-optical elements comprising multilayered aperture arrays and inverted micro-lens arrays directly stacked over an image sensor. This optical component was integrated with a complementary metal oxide semiconductor image sensor.
This is first demonstration of super-resolution imaging which acquires a single integrated image with high contrast and high resolving power reconstructed from high-contrast array images. It is expected that this ultrathin arrayed camera can be applied for further developing mobile devices, advanced surveillance vehicles, and endoscopes.
Professor Jeong said, “This research has led to technological advances in imaging technology. We will continue to strive to make significant impacts on multidisciplinary research projects in the fields of microtechnology and nanotechnology, seeking inspiration from natural photonic structures.”
This work was featured in Light Science & Applications last month and was supported by the National Research Foundation (NRF) of and the Ministry of Health and Welfare (MOHW) of Korea.
Image credit: Professor Ki-Hun Jeong, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Kisoo Kim, Kyung-Won Jang, Jae-Kwan Ryu, and Ki-Hun Jeong. (2020) “Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging”. Light Science & Applications. Volume 9. Article 28. Available online at https://doi.org/10.1038/s41377-020-0261-8
Profile:
Ki-Hun Jeong
Professor
kjeong@kaist.ac.kr
http://biophotonics.kaist.ac.kr/
Department of Bio and Brain Engineering
KAIST
Profile:
Kisoo Kim
Ph.D. Candidate
kisoo.kim1@kaist.ac.kr
http://biophotonics.kaist.ac.kr/
Department of Bio and Brain Engineering
KAIST
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2020.03.23 View 15189 -
Recyclable Nano-Fiber Filtered Face Masks a Boon for Supply Fiasco
Wearing a face mask is a common sight in Korea during the COVID-19 outbreak. Due to the overwhelming demand, last week the government started to ration two masks per person per week, as a drastic measure to address the supply fiasco.
The face masks most commonly used are disposable ones, originally made for filtering out up to 94 or 95 percent of fine dust, referred to as N94 or N95 masks.
A KAIST research team announced that they have developed a nano-filter that maintains excellent filtering efficiency even after hand washing through the development of proprietary technology that aligns nanofibers with a diameter of 100~500 nm in orthogonal or unidirectional directions. This reusable nano-filtered face mask could help to relieve the challenges arising from the supply shortage of face masks.
Professor Il-Doo Kim’s nano-fiber filtered mask will maintain its sturdy frame and filtering function even after being washed more than 20 times. Professor Kim, who has continued to study the filtering of fine dust using nano-filters, is now awaiting final approval from the Ministry of Food and Drug Safety to bring his product into the market.
Professor Kim used an insulation block electrospinning process to manufacture orthogonal nanofibers by controlling the alignment of nanofibers. This structure can minimize delivering of the pressure toward the air filter and maximize the filtration efficiency, which is different from existing disposable masks without nano-fibers.
Existing masks also fail to maintain their air filtering function because their electrostatic function disappears when exposed to water. Thus, their filtering efficiency is reduced significantly, making it almost impossible to reuse them. However, this nano-fiber design was proven to be water resistant with more than 94% filtering efficiency in 20 repeated bactericidal tests with ethanol. The nano-fiber mask also showed no deformation in its nano-membrane structure despite the 20 hand washes. In particular, it was confirmed that there were no deformations in the membrane, even after soaking in ethanol more than three hours.
Professor Kim said, “We believe that this mask can be reusable for about a month even after washing in ethanol. The inner filter can also be replaced.” He added, “We found that the mask filters out up to 80 percent of 600-nanometer particles even after undergoing a bending test more than 4,000 times.”
Professor Kim established his startup company, the “Kim Il-Doo Research Institute,” last February. It can currently produce 1,500 nano-fiber filters per day.
2020.03.17 View 21136 -
COVID-19 Update: All Undergrad Housing Closed
KAIST stepped up preventive measures against the outbreak of COVID-19 by closing all housing complexes for undergraduate students.
Provost Kwang-Hyung Lee, in an email to KAIST community members on March 12, advised all undergraduate students who had already moved in to the dormitories to move out by March 23. The university opened the spring semester on March 16, two weeks later than originally scheduled, due to the outbreak. All in-person classes have been shifted to online classes and this will continue until further notice.
“The dormitory would likely become the source of a COVID-19 cluster on the campus. Given the gravity of the current situation, we can’t help but make this unprecedented measure. It is fully for the best interests for our students’ health and safety. It saddens me to say that students are required to go back to their homes,” said Provost Lee. Dormitory fees will be refunded, and transportation and storage services will be provided for students who return back home. It has not yet been decided when they can return to the campus.
There are four exceptional cases for this special measure: 1. when a student does not have legal residency in Korea, 2. if a student’s legal residence is located in a severely affected region such as Daegu, Chongdo, and Kyongsan, 3. if students in their final semester before the graduation need to take a research class that is not available online, 4. if students have a very special reason that does not allow them to stay at home. Such students are required to meet the Associate Vice President of Student Life for approval of the exceptional stay.
Meanwhile, the first day of the online semester on March 16 saw an overwhelming amount of traffic on the remote educational platform, the KAIST learning management system (KLMS), and the real-time platform, Zoom. The two systems were both overloaded. The Dean of the KAIST Academy sent an email to the community, explaining the technical glitch causing the overload. He said his office had fixed the problem, allowing resumed access to the system from inside and outside the campus. Considered the nature of classes that are difficult or impossible to provide online, the university decided to cancel the some of physical training classes such as golf, dance sports, badminton, swimming, and tennis this semester.
Social distancing is another issue the university is enhancing throughout the campus. The university announced new lunch break shifts to disperse the dining hall crowds; the first shift is from 11:30 to 12:30 and the second shift is from 12:30 to 13:30, effective from March 17. The COVID-19 response bulletin also instructed KAIST community members to sit in a row, not face to face, when eating together with colleagues, and asked them to refrain from talking while eating. In addition, a total of 29 virus and fine duster filtering machines have been installed across the campus dining facilities.
The bulletin posted on March 13 restressed the importance of wearing a face mask in compact areas such as elevators and refrain the non-essential business or personal travel. Parents who need to take care of their children due to the closure of schools and day care centers are advised to work from home.
(END)
2020.03.16 View 7105 -
3D Hierarchically Porous Nanostructured Catalyst Helps Efficiently Reduce CO2
- This new catalyst will bring CO2 one step closer to serving as a sustainable energy source. -
KAIST researchers developed a three-dimensional (3D) hierarchically porous nanostructured catalyst with carbon dioxide (CO2) to carbon monoxide (CO) conversion rate up to 3.96 times higher than that of conventional nanoporous gold catalysts. This new catalyst helps overcome the existing limitations of the mass transport that has been a major cause of decreases in the CO2 conversion rate, holding a strong promise for the large-scale and cost-effective electrochemical conversion of CO2 into useful chemicals.
As CO2 emissions increase and fossil fuels deplete globally, reducing and converting CO2 to clean energy electrochemically has attracted a great deal of attention as a promising technology. Especially due to the fact that the CO2 reduction reaction occurs competitively with hydrogen evolution reactions (HER) at similar redox potentials, the development of an efficient electrocatalyst for selective and robust CO2 reduction reactions has remained a key technological issue.
Gold (Au) is one of the most commonly used catalysts in CO2 reduction reactions, but the high cost and scarcity of Au pose obstacles for mass commercial applications. The development of nanostructures has been extensively studied as a potential approach to improving the selectivity for target products and maximizing the number of active stable sites, thus enhancing the energy efficiency.
However, the nanopores of the previously reported complex nanostructures were easily blocked by gaseous CO bubbles during aqueous reactions. The CO bubbles hindered mass transport of the reactants through the electrolyte, resulting in low CO2 conversion rates.
In the study published in the Proceedings of the National Academy of Sciences of the USA (PNAS) on March 4, a research group at KAIST led by Professor Seokwoo Jeon and Professor Jihun Oh from the Department of Materials Science and Engineering designed a 3D hierarchically porous Au nanostructure with two different sizes of macropores and nanopores. The team used proximity-field nanopatterning (PnP) and electroplating techniques that are effective for fabricating the 3D well-ordered nanostructures.
The proposed nanostructure, comprised of interconnected macroporous channels 200 to 300 nanometers (nm) wide and 10 nm nanopores, induces efficient mass transport through the interconnected macroporous channels as well as high selectivity by producing highly active stable sites from numerous nanopores.
As a result, its electrodes show a high CO selectivity of 85.8% at a low overpotential of 0.264 V and efficient mass activity that is up to 3.96 times higher than that of de-alloyed nanoporous Au electrodes.
“These results are expected to solve the problem of mass transfer in the field of similar electrochemical reactions and can be applied to a wide range of green energy applications for the efficient utilization of electrocatalysts,” said the researchers.
This work was supported by the National Research Foundation (NRF) of Korea.
Image credit: Professor Seokwoo Jeon and Professor Jihun Oh, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Hyun et al. (2020) Hierarchically porous Au nanostructures with interconnected channels for efficient mass transport in electrocatalytic CO2 reduction. Proceedings of the National Academy of Sciences of the USA (PNAS). Available online at https://doi.org/10.1073/pnas.1918837117
Profile:
Seokwoo Jeon, PhD
Professor
jeon39@kaist.ac.kr
http://fdml.kaist.ac.kr
Department of Materials Science and Engineering (MSE)
https://www.kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)Daejeon, Republic of Korea
Profile:
Jihun Oh, PhD
Associate Professor
jihun.oh@kaist.ac.kr
http://les.kaist.ac.kr
Department of Materials Science and Engineering (MSE)
Department of Energy, Environment, Water and Sustainability (EEWS)
KAIST
Profile:
Gayea Hyun
PhD Candidate
cldywkd93@kaist.ac.kr
http://fdml.kaist.ac.kr
Flexible Devices and Metamaterials Laboratory (FDML)
Department of Materials Science and Engineering (MSE)
KAIST
Profile:
Jun Tae Song, PhD
Assistant Professor
song.juntae@cstf.kyushu-u.ac.jp
http://www.cstf.kyushu-u.ac.jp/~ishihara-lab/
Department of Applied Chemistry
https://www.kyushu-u.ac.jp
Kyushu UniversityFukuoka, Japan
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2020.03.13 View 14915 -
Scientists Observe the Elusive Kondo Screening Cloud
Scientists ended a 50-year quest by directly observing a quantum phenomenon
An international research group of Professor Heung-Sun Sim has ended a 50-year quest by directly observing a quantum phenomenon known as a Kondo screening cloud. This research, published in Nature on March 11, opens a novel way to engineer spin screening and entanglement. According to the research, the cloud can mediate interactions between distant spins confined in quantum dots, which is a necessary protocol for semiconductor spin-based quantum information processing. This spin-spin interaction mediated by the Kondo cloud is unique since both its strength and sign (two spins favor either parallel or anti-parallel configuration) are electrically tunable, while conventional schemes cannot reverse the sign.
This phenomenon, which is important for many physical phenomena such as dilute magnetic impurities and spin glasses, is essentially a cloud that masks magnetic impurities in a material. It was known to exist but its spatial extension had never been observed, creating controversy over whether such an extension actually existed.
Magnetism arises from a property of electrons known as spin, meaning that they have angular momentum aligned in one of either two directions, conventionally known as up and down. However, due to a phenomenon known as the Kondo effect, the spins of conduction electrons—the electrons that flow freely in a material—become entangled with a localized magnetic impurity, and effectively screen it. The strength of this spin coupling, calibrated as a temperature, is known as the Kondo temperature.
The size of the cloud is another important parameter for a material containing multiple magnetic impurities because the spins in the cloud couple with one another and mediate the coupling between magnetic impurities when the clouds overlap. This happens in various materials such as Kondo lattices, spin glasses, and high temperature superconductors.
Although the Kondo effect for a single magnetic impurity is now a text-book subject in many-body physics, detection of its key object, the Kondo cloud and its length, has remained elusive despite many attempts during the past five decades. Experiments using nuclear magnetic resonance or scanning tunneling microscopy, two common methods for understanding the structure of matter, have either shown no signature of the cloud, or demonstrated a signature only at a very short distance, less than 1 nanometer, so much shorter than the predicted cloud size, which was in the micron range.
In the present study, the authors observed a Kondo screening cloud formed by an impurity defined as a localized electron spin in a quantum dot—a type of “artificial atom”—coupled to quasi-one-dimensional conduction electrons, and then used an interferometer to measure changes in the Kondo temperature, allowing them to investigate the presence of a cloud at the interferometer end.
Essentially, they slightly perturbed the conduction electrons at a location away from the quantum dot using an electrostatic gate. The wave of conducting electrons scattered by this perturbation returned back to the quantum dot and interfered with itself. This is similar to how a wave on a water surface being scattered by a wall forms a stripe pattern. The Kondo cloud is a quantum mechanical object which acts to preserve the wave nature of electrons inside the cloud.
Even though there is no direct electrostatic influence of the perturbation on the quantum dot, this interference modifies the Kondo signature measured by electron conductance through the quantum dot if the perturbation is present inside the cloud. In the study, the researchers found that the length as well as the shape of the cloud is universally scaled by the inverse of the Kondo temperature, and that the cloud’s size and shape were in good agreement with theoretical calculations.
Professor Sim at the Department of Physics proposed the method for detecting the Kondo cloud in the co-research with the RIKEN Center for Emergent Matter Science, the City University of Hong Kong, the University of Tokyo, and Ruhr University Bochum in Germany.
Professor Sim said, “The observed spin cloud is a micrometer-size object that has quantum mechanical wave nature and entanglement. This is why the spin cloud has not been observed despite a long search. It is remarkable in a fundamental and technical point of view that such a large quantum object can now be created, controlled, and detected.
Dr. Michihisa Yamamoto of the RIKEN Center for Emergent Matter Science also said, “It is very satisfying to have been able to obtain real space image of the Kondo cloud, as it is a real breakthrough for understanding various systems containing multiple magnetic impurities. The size of the Kondo cloud in semiconductors was found to be much larger than the typical size of semiconductor devices.”
Publication:
Borzenets et al. (2020) Observation of the Kondo screening cloud. Nature, 579. pp.210-213. Available online at https://doi.org/10.1038/s41586-020-2058-6
Profile:
Heung-Sun Sim, PhD
Professor
hssim@kaist.ac.kr
https://qet.kaist.ac.kr/
Quantum Electron Correlation & Transport Theory Group (QECT Lab)
https://qc.kaist.ac.kr/index.php/group1/
Center for Quantum Coherence In COndensed Matter
Department of Physics
https://www.kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
2020.03.13 View 13246 -
COVID-19 Update: All Classes to Go Online after Semester Opens
All classes of undergraduate and graduate courses will go online from March 16 in a protective measure for the KAIST community to slow the spread of COVID-19. No decision has yet been made for how long the online classes will last. The spring semester will start two weeks later than scheduled due to the outbreak of the COVID-19.
For online classes, professors are uploading their taped class video clips onto the KAIST Learning Management System (KLMS). These classes will be conducted in both real time and on demand. The video conferencing solution Zoom will be employed for real-time online classes, and professors and students will interact using the bulletin board function for on-demand classes.
The university is scaling up its institutional response to protect the KAIST community against the outbreak of the disease following the cancellation and postponing of major academic events including the commencement and matriculation ceremonies scheduled in February and March.
The new protective measures include all sports complexes and facilities temporarily closing from February 24. All building entrance gates are only accessible with those carrying a KAIST ID card. A total of nine fever monitors have been installed in the university headquarter building, main library, dining halls, the day care center at Daejeon campus, and at the Seoul campus.
The Emergency Response Team is posting a daily bulletin and response manual on the KAIST portal system with updates on the number of confirmed cases in Daejeon and other regions including Seoul as well as reminder notices to help contain the spread.
Provost Kwang-Hyung Lee advised KAIST community members to refrain from traveling to the gravely affected region and foreign countries in an email sent on March 11. Anyone who has a travel history in those regions should report it to the Emergency Response Team and self-quarantine for two weeks at home or in a designated dorm complex.
KAIST surveyed all community members’ travel histories last month and instructed those who had traveled to Daegu and foreign countries or had contact with a confirmed patient to go into self-isolation or work from home while conducting intensive self-monitoring. They have been asked to report their temperature to the Emergency Response Team twice a day. The response manual recommends canceling or postponing meetings and events at the campus. “If necessary, we ask that you make a conference call instead,” said the Emergency Response Team.
Meanwhile, the Academic Affairs Office decided to employ a flexible academic schedule in consideration of students’ circumstances during this extraordinary outbreak situation. “We still need to run 16 weeks of classes for the semester but we are being flexible in how the classes can be run. It will wholly depend on the professor and students’ discussions based on their situation. We won’t apply a unilateral mid-term and final exam week during this special time,” said the bulletin from the Academic Affairs Office.
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2020.03.11 View 6863 -
A Single Biological Factor Predicts Distinct Cortical Organizations across Mammalian Species
-A KAIST team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization.-
Researchers have explained how visual cortexes develop uniquely across the brains of different mammalian species. A KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering has identified a single biological factor, the retino-cortical mapping ratio, that predicts distinct cortical organizations across mammalian species.
This new finding has resolved a long-standing puzzle in understanding visual neuroscience regarding the origin of functional architectures in the visual cortex. The study published in Cell Reports on March 10 demonstrates that the evolutionary variation of biological parameters may induce the development of distinct functional circuits in the visual cortex, even without species-specific developmental mechanisms.
In the primary visual cortex (V1) of mammals, neural tuning to visual stimulus orientation is organized into one of two distinct topographic patterns across species. While primates have columnar orientation maps, a salt-and-pepper type organization is observed in rodents.
For decades, this sharp contrast between cortical organizations has spawned fundamental questions about the origin of functional architectures in the V1. However, it remained unknown whether these patterns reflect disparate developmental mechanisms across mammalian taxa, or simply originate from variations in biological parameters under a universal development process.
To identify a determinant predicting distinct cortical organizations, Professor Paik and his researchers Jaeson Jang and Min Song examined the exact condition that generates columnar and salt-and-pepper organizations, respectively. Next, they applied a mathematical model to investigate how the topographic information of the underlying retinal mosaics pattern could be differently mapped onto a cortical space, depending on the mapping condition.
The research team proved that the retino-cortical feedforwarding mapping ratio appeared to be correlated to the cortical organization of each species. In the model simulations, the team found that distinct cortical circuitries can arise from different V1 areas and retinal ganglion cell (RGC) mosaic sizes. The team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization, and this prediction was confirmed by neural parameter analysis of the data from eight phylogenetically distinct mammalian species.
Furthermore, the researchers proved that the Nyquist sampling theorem explains this parametric division of cortical organization with high accuracy. They showed that a mathematical model predicts that the organization of cortical orientation tuning makes a sharp transition around the Nyquist sampling frequency, explaining why cortical organizations can be observed in either columnar or salt-and-pepper organizations, but not in intermediates between these two stages.
Professor Paik said, “Our findings make a significant impact for understanding the origin of functional architectures in the visual cortex of the brain, and will provide a broad conceptual advancement as well as advanced insights into the mechanism underlying neural development in evolutionarily divergent species.”
He continued, “We believe that our findings will be of great interest to scientists working in a wide range of fields such as neuroscience, vision science, and developmental biology.”
This work was supported by the National Research Foundation of Korea (NRF).
Image credit: Professor Se-Bum Paik, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Jaeson Jang, Min Song, and Se-Bum Paik. (2020). Retino-cortical mapping ratio predicts columnar and salt-and-pepper organization in mammalian visual cortex. Cell Reports. Volume 30. Issue 10. pp. 3270-3279. Available online at https://doi.org/10.1016/j.celrep.2020.02.038
Profile:
Se-Bum Paik
Assistant Professor
sbpaik@kaist.ac.kr
http://vs.kaist.ac.kr/
VSNN Laboratory
Department of Bio and Brain Engineering
Program of Brain and Cognitive Engineering
http://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
Profile:
Jaeson Jang
Ph.D. Candidate
jaesonjang@kaist.ac.kr
Department of Bio and Brain Engineering, KAIST
Profile:
Min Song
Ph.D. Candidate
night@kaist.ac.kr
Program of Brain and Cognitive Engineering, KAIST
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2020.03.11 View 11727 -
“A drop of water shall be returned with a rushing river.”
- Chinese KAISTians Donate Supplies to Fight COVID-19 in Daegu -
The Chinese community at KAIST donated 2.49 million won worth of personal protective equipment on March 4 to support on-site medical personnel in the city of Daegu. South Korea has been witnessing a significant surge in novel COVID-19 transmissions, and Daegu and nearby North Gyeongsang Province are the most affected regions.
As the COVID-19 situation grows more serious globally day by day, a Chinese master’s student from the KAIST Department of Civil and Environmental Engineering, Yuewen Jia, suggested a fundraising campaign on the KAIST Chinese Community’s WeChat messenger chat room, and her idea was enthusiastically supported by many peer-members. The KAIST Chinese Community is comprised of 105 undergraduates, graduates, post-doctoral fellows, researchers, and professors.
With Jia’s post-doc colleague Pei Li volunteering to manage the fundraising process, a total of 2.49 million won was collected in 12 days between January 27 and February 7.
The donors, including Qin Xu, a PhD candidate in the School of Electrical Engineering, reportedly asked for their donations to be used to support on-site medical personnel affected by the outbreak. They believed that medical supplies are the most essential in times like these. The group purchased personal protective equipment online and waited for more than 20 days until the items were finally delivered to them. The goods include 1,280 protective caps, 57 protective suits, 15 protective glasses, and two protective face shields.
Given the surging spread of the COVID-19 disease in Korea, where the confirmed cases have increased multi-fold since mid-February, the KAIST Chinese Community decided that their items should be used immediately in Korea, instead of being sent back to their home country as they had planned.
Guoyuan An, a student representative of the community studying for his master’s degree in the School of Computing, said, “Earlier, some members of the KAIST Chinese Community who had visited China were self-quarantined for two weeks in a special facility designated by KAIST as a precautionary measure. Thanks to the outstanding care we received from offices at KAIST including the COVID-19 Task Force Team, the International Office, the Student Offices, and the Clinic, those who were quarantined could return to campus safe and healthy.”
He continued, “KAIST and the Koreans as a whole spared no effort in helping China and Chinese people living in Korea fight the COVID-19 outbreak in its early days, and all of the members of the KAIST Chinese Community felt deeply grateful for all the attention and aid. This has been a definitive reason for us to change the donate recipient from China to Korea.”
“As an old Chinese saying goes, ‘A drop of water shall be returned with a rushing river.’ This proverb means that even if you receive a little help from others, you should return the favor with all you can when others are in need. We decided to make a donation ourselves in hopes that our small contribution could help on-site medical personnel work for the health and wellbeing of Koreans who are affected in that area.” he explained.
The donated items were delivered to the Division of Disaster Preparedness and Emergency Management at the Daegu Metropolitan Government Office, with help from the on-campus medical center KAIST Clinic Pappalardo Center and the KAIST International Scholar and Student Services (ISSS) Team.
Dr. Yun-Jung Lee, the executive director of the KAIST Clinic Pappalardo Center, expressed “a huge thank you to the KAIST Chinese Community for pitching in to help battle this national and global crisis.”
She added, “Their donations have been passed to those in desperate need, and their warm-hearted act of kindness will go a long way.”
(END)
2020.03.05 View 8393 -
Coordination Chemistry and Alzheimer’s Disease
It has become evident recently that the interactions between copper and amyloid-b neurotoxically impact the brain of patients with Alzheimer’s disease. KAIST researchers have reported a new strategy to alter the neurotoxicity in Alzheimer’s disease by using a rationally designed chemical reagent.
This strategy, developed by Professor Mi Hee Lim from the Department of Chemistry, can modify the coordination sphere of copper bound to amyloid-b, effectively inhibiting copper’s binding to amyloid-b and altering its aggregation and toxicity. Their study was featured in PNAS last month.
The researchers developed a small molecule that is able to directly interact with the coordination sphere of copper–amyloid-b complexes followed by modifications via either covalent conjugation, oxidation, or both under aerobic conditions. The research team simply utilized copper–dioxygen chemistry to design a chemical reagent.
Answering how peptide modifications by a small molecule occur remains very challenging. The system includes transition metals and amyloidogenic proteins and is quite heterogeneous, since they are continuously being changed. It is critical to carefully check the multiple variables such as the presence of dioxygen and the type of transition metal ions and amyloidogenic proteins in order to identify the underlying mechanisms and target specificity of the chemical reagent.
The research team employed various biophysical and biochemical methods to determine the mechanisms for modifications on the coordination sphere of copper–Aꞵ complexes. Among them, peptide modifications were mainly analyzed using electrospray ionization-mass spectrometry.
Mass spectrometry (MS) has been applied to verify such peptide modifications by calculating the shift in exact mass. The research team also performed collision-induced dissociation (CID) of the target ion detected by MS to pinpoint which amino acid residue is specifically modified. The CID fragmentizes the amide bond located between the amino acid residues. This fragmental analysis allows us to identify the specific sites of peptide modifications.
The copper and amyloid-b complexes represent a pathological connection between metal ions and amyloid-b in Alzheimer’s disease. Recent findings indicate that copper and amyloid-b can directly contribute toward neurodegeneration by producing toxic amyloid-b oligomers and reactive oxygen species.
Professor Lim said, “This study illustrates the first experimental evidence that the 14th histidine residue in copper–amyloid-b complexes can be specifically modified through either covalent conjugation, oxidation, or both. Considering the neurotoxic implications of the interactions between copper and amyloid-b, such modifications at the coordination sphere of copper in amyloid-b could effectively alter its properties and toxicity.”
“This multidisciplinary study with an emphasis on approaches, reactivities, and mechanisms looks forward to opening a new way to develop candidates of anti-neurodegenerative diseases,” she added. The National Research Foundation of Korea funded this research.
2020.03.03 View 6692 -
Professor Hojong Chang’s Research Team Wins ISIITA 2020 Best Paper Award
The paper written by Professor Hojong Chang’s research team from KAIST Institute for IT Convergence won the best paper award from the International Symposium on Innovation in Information Technology Application (ISIITA) 2020, held this month at Ton Duc Thang University in Vietnam.
ISIITA is a networking symposium where leading researchers from various fields including information and communications, biotechnology, and computer systems come together and share on the convergence of technology.
Professor Chang’s team won the best paper award at this year’s symposium with its paper, “A Study of Single Photon Counting System for Quantitative Analysis of Luminescence”. The awarded paper discusses the realization of a signal processing system for silicon photomultipliers.
The silicon photomultiplier is the core of a urinalysis technique that tests for sodium and potassium in the body using simple chemical reactions. If our bodily sodium and potassium levels exceed a certain amount, it can lead to high blood pressure, cardiovascular problems, and kidney damage.
Through this research, the team has developed a core technique that quantifies the sodium and potassium discharged in the urine. When the reagent is injected into the urine, a very small amount of light is emitted as a result of the chemical reaction. However, if there is a large amount of sodium and potassium, they interrupt the reaction and reduce the emission. The key to this measurement technique is digitizing the strength of this very fine emission of light. Professor Chang’s team developed a system that uses a photomultiplier to measure the chemiluminescence.
Professor Chang said, “I look forward for this signal processing system greatly helping to prevent diseases caused by the excessive consumption of sodium and potassium through quick and easy detection.”
Researcher Byunghun Han who carried out the central research for the system design added, “We are planning to focus on miniaturizing the developed technique, so that anyone can carry our device around like a cellphone.”
The research was supported by the Ministry of Science and ICT.
(END)
2020.02.27 View 8495 -
KAIST Launches AI Alliance with KT, Hyundai, ETRI, Hanyang University
KAIST launched the AI collaboration alliance “AI One Team” partnering with the nation’s top telecommunications company KT, the Electronics and Telecommunications Research Institute (ETRI), Hyundai Heavy Industries Holdings, and Hanyang University on February 21.
President Sung-Chul Shin signed the MOU with KT CEO Hyun-Mo Koo, Hyundai Heavy Industries Holdings Vice President Ki-Sun Chung, President Myung Joon Kim of ETRI, and Hanyang University President Woo-Seung Kim to help the nation’s AI technology stay ahead of the global level. Vice Minister of Science and ICT Seokyoung Jang also attended the signing ceremony held at KAIST.
Four parties representing the government, industry, research institutes, and universities all agreed to collaborate to establish an educational platform fostering AI talents; develop AI technologies applicable to industrial sites; nurture an AI technology eco-system that will embrace SEMs and venture companies; and incubate startups to help improve their technological competitiveness.
KAIST will take the lead in fostering AI talents in collaboration with ETRI and Hanyang University, offering an online/offline educational program featuring AI curricula that will be practically applicable to the industry. The alliance will also create a platform that will match job seekers and companies, especially for SMEs and venture firms that are having trouble finding competitive experts.
Hyundai Heavy Industries Holdings is focusing on developing technologies in the fields of robotics and smart factories. Hyundai’s collaboration with KT is pushing the digital transformation in the new domains of 5G-based robots and smart factories. The two companies plan to expand their technological know-how to SMEs, venture firms, and startups. The secretariat of the AI One Team will facilitate collaborative projects among the partners to help produce tangible results.
President Shin expressed his high hopes on this alliance for AI technology. He declared, “The winner takes all in the field of AI. Our close collaboration will pave the way for Korea, and each of our partners will lead AI technology in the global market. We will spare no effort for this alliance.”
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Professor Minsoo Rhu Recognized as Facebook Research Scholar
Professor Minsoo Rhu from the School of Electrical Engineering was selected as the recipient of the Systems for Machine Learning Research Awards presented by Facebook.
Facebook launched the award last year with the goal of funding impactful solutions in the areas of developer tookits, compilers and code generation, system architecture, memory technologies, and machine learning accelerator support.
A total of 167 scholars from 100 universities representing 26 countries submitted research proposals, and Facebook selected final 10 scholars. Professor Rhu made the list with his research topic ‘A Near-Memory Processing Architecture for Training Recommendation Systems.’ He will receive 5,000 USD in research funds at the award ceremony which will take place during this year’s AI Systems Faculty Summit at the Facebook headquarters in Menlo Park, California.
Professor Rhu’s submission was based on research on ‘Memory-Centric Deep Learning System Architecture’ that he carried out for three years under the auspices of Samsung Science and Technology Foundation from 2017. It was an academic-industrial cooperation research project in which leading domestic companies like Samsung Electronics and SK Hynix collaborated to make a foray into the global memory-centric smart system semiconductor market.
Professor Rhu who joined KAIST in 2018 has led various systems research projects to accelerate the AI computing technology while working at NVIDIA headquarters from 2014.
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