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Professor Seyun Kim Identifies a Neuron Signal Controlling Molecule
A research team led by Professor Seyun Kim of the Department of Biological Sciences at KAIST has identified inositol pyrophosphates as the molecule that strongly controls neuron signaling via synaptotagmin. Professors Tae-Young Yoon of Yonsei University’s Y-IBS and Sung-Hyun Kim of Kyung Hee University’s Department of Biomedical Science also joined the team. The results were published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on June 30, 2016. This interdisciplinary research project was conducted by six research teams from four different countries and covered a wide scope of academic fields, from neurobiology to super resolution optic imaging. Inositol pyrophosphates such as 5-diphosphoinositol pentakisphos-phate (5-IP7), which naturally occur in corns and beans, are essential metabolites in the body. In particular, inositol hexakisphosphate (IP6) has anti-cancer properties and is thought to have an important role in cell signaling. Inositol pentakisphosphate (IP7) differs from IP6 by having an additional phosphate group, which was first discovered 20 years ago. IP7 has recently been identified as playing a key role in diabetes and obesity. Psychopathy and neurodegenerative diseases are known to result from the disrupted balance of inositol pyrophosphates. However, the role and the mechanism of action of IP7 in brain neurons and nerve transmission remained unknown. Professor Kim’s team has worked on inositol pyrophosphates for several years and discovered that very small quantities of IP7 control cell-signaling transduction. Professor Yoon of Yonsei University identified IP7 as a much stronger inhibitor of neuron signaling compared to IP6. In particular, IP7 directly suppresses synaptotagmin, one of the key proteins in neuron signaling. Moreover, Professor Kim of Kyung Hee University observed IP7 inhibition in sea horse neurons. Together, the joint research team identified inositol pyrophosphates as the key switch metabolite of brain-signaling transduction. The researchers hope that future research on synaptotagmin and IP7 will reveal the mechanism of neuron-signal transduction and thus enable the treatment of neurological disorders. These research findings were the result of cooperation of various science and technology institutes: KAIST, Yonsei-IBS (Institute for Basic Science), Kyung Hee University, Sungkyunkwan University, KIST, University of Zurich in Switzerland, and Albert-Ludwigs-University Freiburg in Germany. Schematic Image of Controlling the Synaptic Exocytotic Pathway by 5-IP7 , Helping the Understanding of the Signaling Mechanisms of Inositol Pyrophosphates
2016.07.21
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KAIST Team Develops Technology to Enable Unzipping of the Graphene Plane
Professor Sang-Wook Kim’s research team of the Material Science and Engineering Department has developed a technique, which enables unzipping of the graphene plane without uncontrollable damage. The research findings were published online on the January 22 issue of Nature Communications. Graphene is a form of carbon in which its atoms form a honey-comb structure through chemical bonding. If this structure can be cut to a desired form, other carbon materials with nanostructure can be created. Many researchers have tried to obtain the accurate unzipping of graphene structures, but faced challenges doing so. To break a very strong bond between carbon atoms, an equivalently strong chemical reaction must be induced. But the chemical reaction not only cuts out the desirable borders, but also damages the surrounding ones. Conventional techniques, which cut out graphene at once, damaged the chemical properties of the graphene structure after unzipping. This is similar to wearing out paper while manipulating it. To solve this problem, the research team adopted “heteroatom doping.” The idea is similar to a sheet of paper being split following a groove drawn on the sheet. After making some regions of the structure unstable by doping other atoms such as nitrogen on a carbon plane, the regions are electrochemically stimulated to split the parts. Nitrogen or other atoms act as the groove on the grapheme plane. The researchers finely controlled the amount of unzipping graphene by adjusting the amount of heteroatom dopants, from which they were able to create a quality nano graphene without any damage in its 2-dimensional crystalline structure. Using this technique, the researchers were able to obtain a capacitor with state-of-the-art energy transfer speed. The nano graphene can be combined with polymer, metal, and semiconductor nano molecules to form carbon composites. Professor Kim said, “In order to commercialize this technique, heteroatom doping should be researched further. We plan to develop fabric-like carbon materials with excellent mechanical and electrical properties using this technique.” Picture 1: Unzipped Carbon Nano Tube Picture 2: Development of Nano Graphene from Carbon Nano Tube Using Heteroatom Dopants Korean descriptions translated into English: Unzipping Process of Graphene Carbon Nano Tube → Nano Graphen Heteroatom This process is similar to a paper being split in two from a tiny hole punched therein.
2016.03.22
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Public Lectures on the Korean Language and Alphabet
The School of Humanities and Social Sciences at KAIST will offer public lectures on the Korean language and alphabet, Hangul, from March 22, 2016 to April 26, 2016. The lectures, which are entitled “The Riddle of Hangul,” will take place on campus in Daejeon. A total of six lectures will be held on such topics as the origin of Korean, the grammar of ancient Korean in the Chosun Dynasty (1392-1897), and subsequent developments in contemporary Korean. Professor Jung-Hoon Kim, who is responsible for organizing the public lecture program, said, “The audience will have an interesting opportunity to understand the history of Korean and its mechanism, while reviewing the unique spelling system of Hangul. I hope many people will show up for these wonderful classes.” For further information and registration, please visit: http://hss.kaist.ac.kr. All lectures, available only in Korean, are free and open to the public.
2016.03.15
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Professor Joonho Choe Appointed as the President of the KSMCB
Professor Joonho Choe of the Biological Sciences Department at KAIST has been elected the 25th president of Korean Society for Molecular and Cellular Biology (KSMCB). His presidency will last one year, beginning on January 1, 2016. Established in 1989, the Society has served as the largest academic gathering in the field of life sciences, holding an international conference every fall. It has more than 12,400 fellows. Professor Choe served as the vice president of KSMC as well as the editor of its journal, Molecules and Cells. He said, “The 2016 International Conference of the KSMCB will take place on October 12-14, 2016 at the COEX Convention and Exhibition Hall in Seoul. This year, we are preparing 20 symposiums and will invite four international renowned keynote speakers in the field including a Nobel Laureate. We hope many people, students and young researchers in particular, from academia and industry will join the conference.” Professor Choe received his doctoral degree from the University of California, Los Angeles (UCLA) after graduating from Seoul National University with his bachelor and master’s degrees.
2016.01.05
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Dr. Ryu of KAIST Receives the S-Oil Outstanding Paper Award
Dr. Je-Kyung Ryu of KAIST’s Department of Physics has been awarded the S-Oil Outstanding Paper Award for his doctoral dissertation’s originality and applicability. Professor Tae-Young Yoon of Physics is his doctoral advisor. The award ceremony took place on November 25, 2015 at the Press Center in Seoul. This S-Oil Outstanding Paper Award, jointly sponsored by the Korean Academy of Science and Technology (KAST) and the Scholastic University Presidential Association, was established to foster young talented scientists in basic science and to advance the field. The award is given every other year for each of the fields of physics, chemistry, mathematics, biology, and earth sciences. With the award, Dr. Ryu received a research grant of USD 8,600. He discovered, for the first time in the world, how NSF (N-ethylmaleimide-sensitive factor), a protein involved in a vesicular transport in cellular activities, disassembles a SNARE (soluble NSF attachment protein receptor) complex, using a unimolecular biophysics method. Unlike the existing studies, he proposed a model in which NSF disassembles SNARE complexes at one step, and as a result, provided evidence of how the SNARE complex influenced the fusion of biological membranes. His research was published in the scientific journal Science issued on March 27, 2015. The title of the paper is “Spring-loaded Unraveling of a Single SNARE Complex by NSF in One Round of ATP Turnover.”
2015.11.27
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KAIST and Four Science and Technology Universities Host a Start-up Competition
KAIST and four other science and technology universities, such as Gwangju Institute of Science and Technology (GIST), Ulsan National Institute of Science and Technology (UNIST), Daegu Gyeongbuk Institute of Science and Technology (DGIST), and Pohang University of Science and Technology (POSTECH), hosted a startup competition on November 27, 2015 at the Dongdaemun Design Plaza in Seoul. Approximately 150 participants including students from the five universities, "angel" investors, and entrepreneurs attended the competition. The competition was held to promote startups that are based on research achievements in science and technology and to foster entrepreneurs with great potential. Two hundred and sixty applicants from 81 teams competed this year. Only ten teams made it to the finals. KAIST students presented two business plans: an experience-centered education platform and mobile taxi-pooling service. Students from other universities presented a brain-stimulating simulation software (GIST), handy smart health trainer (GIST), real-time reporting system for luggage (DGIST), a flower delivery system (UNIST), surveillance and alarm system for stock-related events via machinery studies (UNIST), augmented emotion toys using augmented reality (POSTECH), and a nasal spray for fine dust prevention (POSTECH). KAIST also displayed an exhibition of “wearable haptic device for multimedia contents” and “next generation recommendation service platform based on one-on-one matching system with high expandability and improved user experience system.” The winning team received an award from the Minister of Science, ICT and Future Planning of Korea, as well as an opportunity to participate in overseas startup programs over the course of ten days. Joongmyeon Bae, Director of the KAIST Industry and University Cooperation, who organized the contest, said, “The alumni of Stanford University (USA) has annually created over 5.4 million jobs through startup activities. Likewise, we hope that our event will contribute to job creation by fostering innovative entrepreneurs.”
2015.11.26
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Using Light to Treat Alzheimer's Disease
Medical application of photoactive chemicals offers a promising therapeutic strategy for neurodegenerative diseases. A research team jointly led by Professor Chan Beum Park of the Materials Science and Engineering Department at KAIST and Dr. Kwon Yu from the Bionano Center at the Korea Research Institute of Bioscience and Biotechnology (KRIBB) conducted research to suppress an abnormal assembly of beta-amyloids, a protein commonly found in the brain, by using photo-excited porphyrins. Beta-amyloid plaques are known to cause Alzheimer's disease. This research finding suggests new ways to treat neurodegenerative illnesses including Alzheimer's disease. It was published online as the lead article in the September 21th issue of Angewandte Chemie. The title of the article is “Photo-excited Porphyrins as a Strong Suppressor of ß-Amyloid Aggregation and Synaptic Toxicity.” Light-induced treatments using organic photosensitizers have advantages to managing the treatment in time and area. In the case of cancer treatments, doctors use photodynamic therapies where a patient is injected with an organic photosensitizer, and a light is shed on the patient’s lesion. However, such therapies had never been employed to treat neurodegenerative diseases. Alzheimer's starts when a protein called beta-amyloid is created and deposited in a patient’s brain. The abnormally folded protein created this way harms the brain cells by inducing the degradation of brain functions, for example, dementia. If beta-amyloid creation can be suppressed at an early stage, the formation of amyloid deposits will stop. This could prevent Alzheimer’s disease or halt its progress. The research team effectively prevented the buildup of beta-amyloids by using blue LED lights and a porphyrin inducer, which is a biocompatible organic compound. By absorbing light energy, a photosensitizer such as porphyrin reaches the excitation state. Active oxygen is created as the porphyrin returns to its ground state. The active oxygen oxidizes a beta-amyloid monomer, and by combining with it, disturbs its assembly. The technique was tested on drosophilae or fruit flies, which were produced to model Alzheimer on invertebrates. The research showed that symptoms of Alzheimer's disease in the fruit flies such as damage on synapse and muscle, neuronal apoptosis, degradation in motility, and decreased longevity were alleviated. Treatments with light provide additional benefits: less medication is needed than other drug treatments, and there are fewer side effects. When developed, photodynamic therapy will be used widely for this reason. Professor Park said, “This work has significance as it was the first case to use light and photosensitizers to stop deposits of beta-amyloids. We plan to carry the research further by testing compatibility with other organic and inorganic photosensitizers and by changing the subject of photodynamic therapy to vertebrate such as mice.” Picture 1 – Deposits of Beta-Amyloid in Fruit Flies Stopped by Using Porphyrin and Blue LED Lights Picture 2 – The Research Finding Published as the Lead Article in Angewandte Chemie (September 2015)
2015.11.11
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Public Lectures by KAIST's Humanities and Social Sciences Research Center
The Humanities and Social Sciences Research Center at KAIST offers public lectures at the International Seminar Hall of the Humanities and Social Sciences building on campus from November 12, 2015 to December 10, 2015. There will be four lectures, all of which will be available in Korean only. The theme of the lectures is “social issues and strategic solutions.” Experts in various fields including women’s studies, criminal psychology, Go (a Chinese board game) and its philosophy, and Korean studies will participate, offering multifaceted analysis and solutions for social issues in Korea. Joo-Hee Kim, a researcher at the Korean Women’s Institute of Ewha Women’s University, will lecture on “Problems of Loan Products Exclusively for Women” and discuss the background of "micro-loans" which are often targeted at women, while evaluating the logic of financial corporations behind marketing such products. Lectures by Professor Ji-Sun Park from the Department of Social Psychology at Ewha Women’s University on “Understanding of Criminal Psychology from Letters,” Professor Soo-Hyun Jeong from the Department of Go at Myeongji University on “Life Lessons and Strategies from Playing Go,” and Professor Seung-Taek Ahn from Kyujanggak Institute for Korean Studies of Seoul National University on “Community Problems in Folk Culture” will follow. The organizer of the lectures, Professor Jung-Hoon Kim of the Department of Humanities and Social Sciences at KAIST said, “These lectures will provide local citizens and the KAIST family a wonderful opportunity to understand important social issues from the perspective of social science. It will also serve as a valuable time to think about how our social conflicts could differ from those of other countries, helping us to find solutions.” To register for these free lectures, go to http://hss.kaist.ac.kr by November 9, 2015.
2015.11.06
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Professors Sukbok Chang and Jang-Wook Choi Receive the 2015 Knowledge Award from the Korean Government
The Ministry of Science, ICT and Future Planning (MISP) of the Republic of Korea announced the 2015 Knowledge Awards on October 20, 2015. Two KAIST professors received the award. Established in 2009, the awards are presented to Korean scientists whose publications have contributed to the international science community. Specifically, the MISP used the two biggest science databases, Science Citation Index Expanded (SCIE) and Scopus, to identify ten highly cited papers ranked in the top 1% by total citations in the past ten years. Professor Sukbok Chang of Chemistry (left in the picture below) is a global authority in the field of catalytic hydrocarbon functionalization. His paper entitled “Palladium-catalyzed C-H Functionalization of Pyridine N-Oxides: Highly Selective Alkenylation and Direct Arylation with Unactivated Arenes,” which was published in the Journal of the American Chemical Society in 2008, was once selected by Thomson Reuters as one of the “Most Influential Research Papers of the Month.” In 2011, the American Chemical Society included his paper in the list of the top 20 research papers that were most frequently cited in the last three years. Professor Jang-Wook Choi of the Graduate School of EEWS (Energy, Environment, Water, and Sustainability) has been known for his leading research in rechargeable battery, supercapacitor, and materials chemistry. In particular, his work on secondary fuel cells attracted significant attention from academia and industry in Korea. Professor Choi developed a super-thin flexible lithium-ion battery this year, thinner than a credit card, which lasts longer than the existing batteries and with greater performance. He also developed new electrode materials for next-generation sodium-ion and magnesium secondary fuel cells. Professor Sukbok Chang (left) and Professor Jang-Wook Choi (right)
2015.10.23
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Nikon Instruments Korea Donates a Fund to KAIST's Department of Biological Sciences
Representatives from Nikon Instruments Korea Co., Ltd., a producer of microscopes and measuring instruments, visited the KAIST campus on September 25, 2015, and donated USD 9,000 to the Department of Biological Sciences at KAIST. A small ceremony to mark the donation took place at the department’s conference room. In the picture from left to right were Professor Won-Do Heo, Department Head Byung-Ha Oh, Professor Sangyong Jon, President Sam-Sup Jang of Korea Instech, and Director Ik-Soo Yoo of Nikon Instruments Korea. The department announced that the fund would be used to build its new research center to house the state-of-the-art research equipment and tools for the development of new medicine.
2015.10.03
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Moon Soul Graduate School of Future Strategy at KAIST Creates the Next Generation Open Forum 2045
Open forums for envisioning the next 30 years for Korea from the perspective of young people will be held in five metropolitan cities in Korea. Organized by KAIST and hosted by the Ministry of Science, ICT and Future Planning and the Committee for the 70th Anniversary of Korean Liberation, the Next Generation Open Forum 2045 invites young people to shape the future image of Korea for the upcoming 100th anniversary of Korean liberation. It will start off with its first event on September 22 in the Millennium Hall of Konkuk University in Seoul. In this event, a panel and invited guests will discuss employment issues with a view to ameliorating problems prevalent in the society. A robotics scientist, Dr. JK Han will address the impact of robot automation on the job issue as a keynote speaker, and a performance featuring human-size robot actor will follow his talk to celebrate the opening of the event. Invited guests can actively participate in the discussion by suggesting their opinions on job issue of the future and by voting on their smartphone apps during the event. Every opinion conveyed during the discussion will be printed and put in a time capsule, which will be opened in 2045 for the celebration of 100th anniversary of Korean liberation. The Moon Soul Graduate School of Future Strategy of KAIST will organize events in five cities including Daegu, Daejeon, Busan, and Gwangju with topics including education, science and technology, unification diplomacy, and culture. The event will end with a symposium held in Seoul. Perspective applicants can apply for free to the Next Generation Open Forum 2045 on the official website of the Committee for the 70th Anniversary of Korean Liberation.
2015.09.22
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Professor Woontack Woo Demonstrates an Optical Platform Technology for Augmented Reality at Smart Cloud Show
Professor Woontack Woo of the Graduate School of Culture Technology at KAIST participated in the Smart Cloud Show, a technology exhibition, hosted by the university’s Augmented Human Research Center and presented the latest development of his research, an optical platform system for augmented reality. This event took place on September 16-17, 2015 at Grand Seoul Nine Tree Convention Center in Seoul. At the event, Professor Woo introduced a smart glass with an embedded augmented reality system, which permits remote collaboration between an avatar and the user’s hand. The previous remote collaboration was difficult for ordinary users to employ because of its two-dimensional screen and complicated virtual reality system. However, with the new technology, the camera attached to artificial reality (AR) glasses recognizes the user’s hand and tracks it down to collaborate. The avatar in the virtual space and the user’s hand interact in real space and time. The key to this technology is the stable, real-time hand-tracking technique that allows the detection of the hand’s locations and the recognition of finger movements even in situations of self-occlusion. Through this method, a user can touch and manipulate augmented contents as if they were real-life objects, thereby collaborating remotely with another user who is physically distant by linking his or her movements with an avatar. If this technology is adopted widely, it may bring some economic benefits such as increased productivity due to lower costs for mobility and reduction in social overhead costs from the decrease in the need of traveling long distance. Professor Woo said, “This technology will provide us with a greater opportunity for collaboration, not necessarily restricted to physical travelling, which can be widely used in the fields of medicine, education, entertainment, and tourism.” Professor Woo plans to present his research results on hand-movement tracking and detection at the 12th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI 2015), to be held on October 28-30, 2015, at Kintex in Goyang, Korea. He will also present a research paper on remote collaboration at the ICAT-EGVE 2015 conference, the merger of the 25th International Conference on Artificial Reality and Telexistence (ICAT 2015) and the 20th Eurographics Symposium on Virtual Environments (EGVE 2015), which will take place on October 28-30, 2015 at the Kyoto International Community House, Kyoto, Japan.
2015.09.16
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