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Nanoparticle Cluster Manufacturing Technique Using DNA Binding Protein Developed
Professor Hak-Sung Kim of the Department of Biological Sciences at KAIST and Yiseul Ryu, a doctoral candidate, used the Zinc Finger protein that specifically binds to target DNA sequence to develop a new manufacturing technique for size-controllable magnetic Nanoparticle Clusters (NPCs). Their research results were published in Angewandte Chemie International Edition online on 25 November 2014.
NPCs are structures consisting of magnetic nanoparticles, gold nanoparticles, and quantum dots, each of which are smaller than 100 nm (10-9m). NPCs have a distinctive property of collectivity not seen in single nanoparticles.
Specifically NPCS differ in physical and optical properties such as Plasmon coupling absorbance, energy transfers between particles, electron transfers, and conductivity. Therefore, NPCs can be employed in biological and medical research as well as the development of nanoelectric and nanoplasmon devices.
To make use of these novel properties, the size and the composition of the cluster must be exquisitely controlled. However, previous techniques relied on chemical binding which required complex steps, making it difficult to control the size and composition of NPCs.
Professor Kim’s team used Zinc Finger, a DNA binding protein, to develop a NPCs manufacturing technique to create clusters of the desired size easily. The Zinc Finger protein contains a zinc ion and specifically recognizes DNA sequence upon binding, which allows the exquisite control of the size and the cluster composition. The technique is also bio-friendly.
Professor Kim’s team created linear structure of different sizes of NPCs using Zinc Finger proteins and three DNA sequences of different lengths. The NPCs they produced confirmed their ability to control the size and structure of the cluster by using different DNA lengths.
The NPCs showed tripled T2 relaxation rates compared to the existing MRI contrast media (Feridex) and effectively transported to targeted cells. The research findings show the potential use of NPCs in biological and medical fields such as MRI contrast media, fluorescence imaging, and drug transport.
The research used the specific binding property of protein and DNA to develop a new method to create an inorganic nanoparticle’s supramolecular assembly. The technique can be used and applied extensively in other nanoparticles for future research in diagnosis, imaging, and drug and gene delivery.
Figure 1. A Mimetic Diagram of NPCs Manufacturing Technique Using DNA Binding Protein Zinc Finger
Figure 2. Transmission Electron Microscopy Images showing different sizes of NPCs depending on the length of the DNA
2014.12.04 View 11925 -
SmileGate Membership Program for Students and Video Game Industry in Korea
The Office of University and Industry Cooperation at KAIST and SmileGate, a video game developer based in Korea, agreed in June 2014 to cooperate in the development of talents for the video game industry in Korea and to support students’ startup efforts.
The company established the SmileGate Studio at the KAIST campus in 2010 and has been supporting KAIST students who are interested in video game design and development, such as hosting design competitions and offering networking opportunities as well as consulting services for startups.
The Studio launched a scholarship program called the “SmileGate Membership” in November this year to offer 12 students research funding, equipment and tools for game design and development, and mentoring services for eight months. Participating students will also receive free space for research and development, legal services for business development, investment advice, and assistance in networking with the global community after the completion of the program.
Professor Joongmyeon Bae, the Dean of the KAIST Office of University and Industry Cooperation, said, “This is a great opportunity for our students because they can actually utilize their passion and creativity to make their own games. KAIST and SmileGate will continue to lead the video game industry in Korea through close collaboration.”
2014.12.03 View 8088 -
KAIST Robotic Art: Exhibit called "Artificial Brain, Robots Evolve"
It is not difficult to find the desire to create a Neoanthropinae in the history of mankind. Humans evolve through man-made extensions and live by self-training them. This is Seung Hyun Son’s description which encourages us to discuss the changes man-made humanoids would bring to our future lives. He depicts this in “Theory of Evolution: From mankind to humanoid” in the “Artificial Brain, Robots Evolve” exhibition in the KI Building, KAIST, from 21 November 2014 to 8 February 2015.
KAIST's Art and Design Committee (led by President Myung Seok Kim) is holding the third experimental art exhibition based on the integration of science and art. The previous exhibition themes were “See the Sky” in 2012 and “Life is Beautiful” in 2013. The exhibition is divided into five subtopics: Move, Feel, Think, Express, and Experiment in Imagination.
The exhibits are by 17 artists including Nam June Paik, Nancy Lang, and KAIST Professor Myung Seok Kim. The main exhibits include “Cloud Face,” by Seung Baek Shin and Yong Hoon Kim, that shows up as error on computer but can be seen by human eyes and “Brains in Vat," by Boo Rok Lee and Myung Chul Kim based on KAIST's robotic lab’s materials and motif. Also, “The May of My Life” by Professor Myung Seok Kim’s lab reminds us of the relationship between robot and human.
President Myung Seok Kim said, “The range of content in cultural art will inspire students’ imagination.” He continued, “I hope this exhibition will awaken both scientific ideas and artistic sense.”
The opening ceremony of the exhibition will be held from 14:00, 21 November. The “Artificial Brain, Robots Evolve” exhibition is hosted by the Daejeon Museum of Art and sponsored by National Museum of Modern and Contemporary Art and Soma Museum.
Pictures from top to bottom are Cloud Face, Brains in Vat, The May of My Life_1, and The May of My Life_2.
2014.11.21 View 7313 -
A KAIST Student Team Wins the ACM UIST 2014 Student Innovation Contest
A KAIST team consisted of students from the Departments of Industrial Design and Computer Science participated in the ACM UIST 2014 Student Innovation Contest and received 1st Prize in the category of People’s Choice.
The Association for Computing Machinery (ACM) Symposium on User Interface Software and Technology (UIST) is an international forum to promote innovations in human-computer interfaces, which takes place annually and is sponsored by ACM Special Interest Groups on Computer-Human Interaction (SIGCHI) and Computer Graphics (SIGGRAPH). The ACM UIST conference brings together professionals in the fields of graphical and web-user interfaces, tangible and ubiquitous computing, virtual and augmented reality, multimedia, and input and output devices.
The Student Innovation Contest has been held during the UIST conference since 2009 to innovate new interactions on state-of-the-art hardware. The participating students were given with the hardware platform to build on—this year, it was Kinoma Create, a JavaScript-powered construction kit that allows makers, professional product designers, and web developers to create personal projects, consumer electronics, and "Internet of Things" prototypes. Contestants demonstrated their creations on household interfaces, and two winners in each of three categories -- Most Creative, Most Useful, and the People’s Choice -- were awarded.
Utilizing Kinoma Create, which came with a built-in touchscreen, WiFi, Bluetooth, a front-facing sensor connector, and a 50-pin rear sensor dock, the KAIST team developed a “smart mop,” transforming the irksome task of cleaning into a fun game. The smart mop identifies target dirt and shows its location on the display built in the rod of a mop. If the user turns on a game mode, then winning scores are gained wherever the target dirt is cleaned.
The People’s Choice award was decided by conference attendees, and they voted the smart mop as their most favorite project.
Professor Tek-Jin Nam of the Department of Industrial Design at KAIST, who advised the students, said, "A total of 24 teams from such prestigious universities as Carnegie Mellon University, Georgia Institute of Technology, and the University of Tokyo joined the contest, and we are pleased with the good results. Many people, in fact, praised the integration of creativity and technical excellence our have shown through the smart mop.”
Team KAIST: pictured from right to left, Sun-Jun Kim, Se-Jin Kim, and Han-Jong Kim
The Smart Mop can clean the floor and offer users a fun game.
2014.11.12 View 10229 -
KAIST and Samsung Heavy Industries Celebrate 20 Years of Cooperation
KAIST and Samsung Heavy Industries (SHI) celebrated the twentieth anniversary of their university-industry cooperation in shipbuilding and ocean technology research. Established in 1995, the cooperation has remained steadfast for two decades, even times when Korea suffered gravely from its financial crisis in late 1990s.
A ceremony to commemorate the cooperation took place at the Mechanical Engineering Building on October 17, 2014. About thirty distinguished guests including the Head of the Department of Mechanical Engineering, Professor Choong-Sik Bae, and the chief engineer of SHI Marine Research Institute, Dr. Jong-Soo Seo, participated in the ceremony.
The cooperation programs included appointing advisory professors for technological support, implementing business-based academic courses, offering university-industry wide open lectures, opening regular courses for auditing, and finding possible joint researches. Through this cooperation, Samsung has secured technologies needed for industry, and KAIST has produced students who have real-world experience in industrial fields.
Twenty years of cooperation has produced shining results by running various programs such as technological advice, special lectures, small-scale research projects, consignment research projects, and courses for research and design personnel.
For example, what started as a small-scale research project with USD 4,800 in funding, the LNG (Liquefied Natural Gas) related research has grown into a large-scale research project with a total of USD 2.85 million in funding. As a result, they developed a secondary barrier for LNG carriers which was recognized by Lloyd‘s Register. Their research eventually lowered ship manufacturing costs tremendously.
In 2003, the cooperation project received the presidential citation from the University-Industry Cooperation Competition organized by the Federation of Korean Industries.
KAIST and SHI planned to increase their cooperation to make it Korea’s leading university-industry cooperation program.
Professor Bae said, “Our programs to focus on solving industrial problems have turned out quite successful.” He emphasized that “for this reason, the cooperation even continued during the Asian financial crisis in 1997.”
He added, “By expanding the current cooperation, we aim to make it an exemplary program that contributes to Korea’s shipbuilding and ocean plant industries.”
2014.10.21 View 9074 -
President Steve Kang of KAIST Attends the 2014 Summer Davos Forum in Tianjin, China
President Steve Kang of KAIST will attend the 2014 Annual Meeting of the New Champions, the World Economic Forum (WEF), to be held on September 10-12, 2014 in Tianjin, China.
KAIST holds its own IdeasLab session on nanotechnology on September 12, 2014.
On September 10, 2014, President Steve Kang will participate in a private session hosted by the Global University Leaders Forum (GULF) community at WEF as a panelist.
In addition to President Kang, eight presidents from top global universities such as the National University of Singapore, Peking University, ETH Zurich (Swiss Federal Institute of Technology), University of Tokyo, and Carnegie Mellon University will join the panel discussion under the topic, “Increasing the Translational Impact of University Research.” Specifically, the presidents will address issues related to the importance of university-led technology transfer in Asia, key strategies and goals for technology transfer, and implementation approaches taken by each university to promote technology transfer from university to industry.
President Kang was invited to this GULF session, the only attendant from Korean universities, in recognition of his long time experience and expertise in education and research.
In 2006, WEF created the GULF, a small community of the presidents of top universities in the world, aiming to offer an open platform for high-level dialogues on issues of higher education and research with other sectors, as well as to foster collaboration between universities in areas of significance for global policy.
As of 2014, a total of 25 globally leading universities, including Harvard University, University of Cambridge, and Massachusetts Institute of Technology, are GULF members. KAIST, which joined the club this year, is the only Korean university.
The 2014 Annual Meeting of the New Champions, also known as the Summer Davos Forum, hosts numerous sessions under the theme of “Creating Value through Innovation.” At the Forum, a total of ten IdeasLab sessions will be hosted. KAIST was invited to run its own IdeasLab on nanotechnology on September 12, 2014.
Together with President Kang, Professors Sang Ouk Kim and Keon Jae Lee from the Department of Materials Science Engineering, KAIST, and Professors Sang Yup Lee and Hyunjoo Lee from the Department of Chemical and Biomolecular Engineering, KAIST, will present their own speeches on the topic entitled “From diagnostics to materials, how is nanotechnology changing lives?”
President Kang will give the opening speech at the KAIST IdeasLab.
He said that an invitation from WEF to join the IdeasLab spoke well for KAIST:
“KAIST is the first and the only Korean university ever invited to run its own IdeasLab at the World Economic Forum. The IdeasLab is an expert group meeting, conducted only by the world’s most prestigious universities and research institutes. At the IdeasLab sessions, global leaders from different sectors identify major issues facing higher education and humanity and explore solutions through science and technology innovation. Holding our own IdeasLab on one of our strongest fields, nanotechnology, is indeed an excellent opportunity for KAIST to show its strength in academic and research excellence on the global stage.”
2014.09.08 View 12654 -
News Article on the Development of Synthesis Process for Graphene Quantum Dots
Before It's News, an international online news agency, highlighted the recent research conducted by KAIST professors (Seokwoo Jeon of the Department of Materials Science and Engineering, Yong-Hoon Cho of the Department of Physics, and Seunghyup Yoo of the Department of Electrical Engineering) on the development of synthesis process for graphene quantum dots, nanometer-sized round semiconductor nanoparticles that are very efficient at emitting photons. If commercialized, this synthetic technology will lead the way to the development of paper-thin displays in the future.
For the article, please go to the link below:
Before It’s News, September 3, 2014“Graphene quantum dots prove highly efficient in emitting light”
http://beforeitsnews.com/science-and-technology/2014/09/graphene-quantum-dots-prove-highly-efficient-in-emitting-light-2718190.html
2014.09.07 View 11690 -
Extracting Light from Graphite: Core Technology of Graphene Quantum Dots Display Developed
Professor Seokwoo Jeon of the Department of Materials Science and Engineering, Professor Yong-Hoon Cho of the Department of Physics, and Professor Seunghyup Yoo of the Department of Electrical Engineering announced that they were able to develop topnotch graphene quantum dots from graphite.
Using the method of synthesizing graphite intercalation compound from graphite with salt and water, the research team developed graphene quantum dots in an ecofriendly way.
The quantum dots have a diameter of 5 nanometers with their sizes equal and yield high quantum efficiency. Unlike conventional quantum dots, they are not comprised of toxic materials such as lead or cadmium. As the quantum dots can be developed from materials which can be easily found in the nature, researchers look forward to putting these into mass production at low cost.
The research team also discovered a luminescence mechanism of graphene quantum dots and confirmed the possibility of commercial use by developing quantum dot light-emitting diodes with brightness of 1,000 cd/m2, which is greater than that of cellphone displays.
Professor Seokwoo Jeon said, “Although quantum dot LEDs have a lower luminous efficiency than existing ones, their luminescent property can be further improved” and emphasized that “using quantum dot displays will allow us to develop not only paper-thin displays but also flexible ones.”
Sponsored by Graphene Research Center in KAIST Institute for NanoCentury, the research finding was published online in the April 20th issue of Advanced Optical Materials.
Picture 1: Graphene quantum dots and their synthesis
Picture 2: Luminescence mechanism of graphene quantum dots
Picture 3: Structure of graphene quantum dots LED and its emission
2014.09.06 View 15929 -
IAMCOMPANY, an educational technology startup created by a KAIST student
In-Mo Chung, a senior student of the Department of Industrial Design at KAIST, developed a mobile homework book application, IAMSCHOOL, in order to help parents engage, more interactively, in their children’s school activities.
Chung said in an interview with KAIST:
“I came up with creating my company, IAMCOMPANY, when I worked as a volunteer for a student club in 2009 that provides an educational service to high school students living in a less-favored environment. I found out their educational environment very poor, which ultimately led me to build a public interest business model for education.”
Chung created a few mobile applications including IAMSCHOOL and IAMCLASS. The application, IAMSCHOOL, receives school’s notices, homework assignments, or any information related to classes and sends them directly and immediately to parents, allowing real-time communications between parents and teachers. In Korea, parents usually check as many as 50 school notices per month.
Once registered, private educational institutes and public organizations can also receive school information through this application.
In July 2011, the Department of Science Management at KAIST hosted a student competition for startup ideas, and Chung’s idea to build an educational application won the best award. In 2012, he received the grand prize at the KAIST E-5 Startup Competition.
An undergraduate student who is the chief executive officer of a tech startup
Chung established IAMCOMPANY with the seed fund of 13 million Korean won that he had received from the city government of Daejeon. His business idea was selected as one of the 300 College Student Startup Projects, a startup support program operated by Daejeon City to encourage entrepreneurship among college and university students.
Chung talked about the background of his business:
“I think that my idea to offer a “free educational application” helped me win the first prize at the student startup competition. At that time, I was still young, so I considered the winning of the competition as an “exercise” to build my own business in the future. But when I actually started my company, I found out that KAIST’s startup programs helped me a lot throughout the entire process and realized that these programs are good enough for young entrepreneurs to build up their company from a single idea.”
KAIST professors and staff support student startups.
Chung took in-depth mentoring from KAIST professors. Professor Min-Hwa Lee of the Department of Management Science and Professor Lak-Kyoung Song of the Department of Technology Management, who is also the president of the Daejeon Creative Economy Innovation Center, have supported Chung’s endeavors. President Taek-Su Kang of the KAIST Innovation Center gave Chung a lot of advice as he was developing IAMCOMPANY’s initial business model. Chung said that even now, they look for solutions together when his business ran into a brick wall.
Professor Lee said, “IAMCOMPANY does not aim for profit. Instead, by supplying free applications, they improve the environment of education and eventually create public interest. Also, they find out consumers’ hidden demands and satisfied it creatively.”
With 8,000 schools registered to IAMSCHOOL, 750,000 parents are using the application in just two years of its release. Parents and teachers responded enthusiastically.
The application “IAMSCHOOL” provides services for 8,000 schools in Korea. Currently, 750,000 parents are using this application.
The company offers the nation’s largest online education service. The reason behind their rapid growth is that their service solves communications problems between schools and parents in a simple and efficient manner.
Jung-Mi Hwang, a teacher at Galma Elementary School in Dajeon, said:
“After using this application, there are fewer occasions of students forgetting their school materials. We think this is because the parents can check the school notices and newsletters at any time through the application.”
She added, “I hope more and more schools will use this application because it is convenient and also available for free.”
Another teacher from Daedeok Elementary School in Daejeon, Dong-Min Nam, said that “many parents like this application since they are immediately notified with school events.”
KAIST’s Technology Business Incubation Center
“After moving around many places due to expensive rent,” Chung said that “we finally moved into the Technology Business Incubation Center (TBIC) at KAIST. The center helped us not only providing the space, but also mentoring and connecting us with venture investment companies. This was a great help in attracting initial investments.”
Chung added:
“At first, a staff member from TBIC was concerned about the viability of my company. I was then an undergraduate student with zero business experience, and from his standpoint, I was taking a huge risk.”
But in several months after its establishment, IAMCOMPANY has grown to have 16 employees.
An investment of 1.5 billion Korean won from a venture capital company led to a sustainable growth.
In early stage, IAMCOMPANY received 300 million Korean won from a venture capital company, and it recently attracted additional 1.2 billion won from a leading venture capital. With these investments, the company grew further. Moreover, investments from large educational corporations have proved the value and competitiveness of the company in the education market.
Chung plans to expand his service globally, particularly in China and Singapore.
He said that he would not forget how he had started his business, and with such a focused mind, he would strive to provide students and parents with quality educational services while proactively incorporating the advanced information technology (IT) into his products.
A bold movement to Pangyo Techno Valley, a Korean version of Silicon Valley
Although the company started with only two members, as of August 2014, it boasts of having twenty employees, a remarkable leap of growth within just two years.
In April this year, Chung relocated his office from TBIC to Pangyo Techno Valley, the Silicon Valley of Korea, in order to provide a better work environment to his staff.
It was not an easy decision for him to leave the comfortable, well-known place, the KAIST campus, and the colleagues, including TBIC staff and KAIST professors, who had helped his startup efforts in early days. However, in order to recruit better employees and to access additional IT resources and education-related companies, Chung decided to make a bold movement, relocating his business to Pangyo Techno Valley in Seoul.
A reputable American venture capital investor, Timothy C. Draper, invested in IAMCOMPANY
Chung was able to secure solid support from an eminent global investor, Timothy C. Draper, the founder of Draper Fisher Jurvetson, a venture capital based in Menlo Park in California.
Recently, Draper, a legendary investor of the Silicon Valley, invested USD 20,000 in IAMCOMPANY. Draper discovered worldwide venture companies such as Hotmail, Skype, and Baidu. IAMCOMPANY received high marks from him as a company with a competitive edge in the global education market.
Chung met Draper in April 2014 when he participated in a television network’s (Korean Broadcasting System) audition program for startups. Draper was one of the judges for the program, and he was impressed by the robust growth of IAMCOMPANY. He eventually made a decision to chip in USD 20,000 in Chung’s company.
Chung said that he was glad to meet the tycoon of Silicon Valley who recognized the potential of his company.
In last October, IAMSCHOOL was selected for the K-APP Global Hub Program—a global market pioneering program to support the development of mobile applications—which was sponsored by the Small and Medium Business Administration in Korea.
IAMCOMPANY will bring ‘the Korean Wave’ in the area of educational applications.
Chung said, “We plan to sustainably manage the applications and add more functions, so that more educational institutions can adopt our application.”
The company aims to provide its service to over 11,000 schools and 100,000 academies nationally so that more parents are able to receive educational news and information easily.
Chung concluded his interview in an upbeat tone as he predicted the future of his company:
“I am proud that IAMSCHOOL is being recognized by the world’s best investor, and I have gained confidence to advance to the global market. Through global service, I want to make "the Korean Wave" in the field of educational applications and to receive appreciation from students, teachers, and parents worldwide.”
2014.09.04 View 9140 -
KAIST's Advanced Biomass R&D Center and ToolGen will cooperate
The Advanced Biomass R&D Center (ABC) at KAIST and ToolGen, Inc., a Korean biotechnology company focused on the development of engineered nucleases that can be used as essential tools for editing genetic information in microbial, plant, animal, and human cells, signed a memorandum of understanding (MOU) on August 18, 2014 for technology exchange and research collaboration.
ABC is headed by Executive Director Ji-Won Yang, a professor emeritus at the Department of Chemical and Biomolecular Engineering, and Chief Executive Officer Jong-Moon Kim for ToolGen.
The newly signed MOU encourages collaborations in the following areas:
- Development of genome editing technology for microalgae modification
- Development of microalgae that increases biofuel production through the
application of genome editing technology
- Creation of education and training programs for researchers
- Collaboration in other areas
In addition, the two organizations decided to cooperate in the improvement of biofuel yields using ToolGen’s genome editing technology, the commercialization of research outcomes, and the development of eco-friendly biofuels from biomass.
Executive Director Yang commented that “improving biofuel production is crucial to accelerate the commercialization of biofuels, and collaborating with ToolGen will help us realize that goal.” He further said that “The importance of this MOU lies in the fact that the global chemical industry including Korea has been making substantial efforts to shift its attention from a fossil fuel-based development to a more bio-based technology.”
Jin-Soo Kim, the director of the Genome Editing Research Center at the Institute of Basic Sciences in Korea and the cofounder of ToolGen, added that “ToolGen has successfully commercialized its third generation genetic scissors, which shows a lot of promise for commercialization. Our collaboration with KAIST will serve as the driving force to create new industries and accordingly, new jobs.”
2014.09.03 View 9725 -
IAMCOMPANY, an educational technology startup created by a KAIST student, featured online in EdSurge
EdSurge is a U.S.-based online news site focused on education and technology innovation, which published an article, dated August 12, 2014, on IAMCOMPANY (http://iamcompany.net), a startup created by a KAIST student, Inmo (Ryan) Chung.
The article introduced one of the company’s most popular and free smartphone applications called “IAMSCHOOL” that “funnels school announcements and class notices to parents’ smartphones using a format similar to Twitter and Google+.”
For more about IAMCOMPANY, please visit the link below:
EdSurge, August 12, 2014
“South Korea’s Biggest Educational Information App Plans Pan-Asian Expansion”
https://www.edsurge.com/n/2014-08-12-south-korea-s-biggest-educational-information-app-plans-pan-asian-expansion
2014.08.19 View 7726 -
Opening of "Education Donation Center" for Knowledge Sharing
KAIST is a leader in knowledge-sharing services for the educationally underprivileged. KAIST held the opening ceremony of the Education Donation Center at its Munji Campus on July 4, 2014 and was appointed as a “2014 Chungcheong-Gangwon province model local education donation center” sponsored by the Education Ministry of Korea and Korea Foundation for the Advancement of Science and Creativity.
The Education Donation Center (EDC) will integrate programs run by the Chungcheong-Gangwon province education donation organizations and introduce them to local chapter organizations. The EDC will recommend new donation organizations to the organizations in need. To ensure efficient donation, the EDC will consult programs of donation organizations. The EDC will also suggest regionally suitable education donation programs. KAIST will provide three staff members, six graduate students, and one to manage the career counselor to the center.
Joo-Sung Lee of the Business & Technology Management Department is the professor in charge of the EDC. He explained, “The center is the medium between the newly participating education donation organizations and the demand organizations. I will invest every effort to provide high-quality educational benefits to educationally underprivileged people."
KAIST has also been running an education service group called ‘Midam Scholarship’, an online education donation group called ‘Chalk’, and science camp programs for youth to establish the sharing and collaboration culture of KAIST.
2014.07.10 View 8075