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Mechanism in regulation of cancer-related key enzyme, ATM, for DNA damage and repair revealed
Professor Kwang-Wook Choi
A research team led by Professor Kwang-Wook Choi and Dr. Seong-Tae Hong from the Department of Biological Sciences at KAIST has successfully investigated the operational mechanism of the protein Ataxia Telangiectasia Mutated (ATM), an essential protein to the function of a crucial key enzyme that repairs the damaged DNA which stores biometric information. The results were published on December 19th Nature Communications online edition.
All organisms, including humans, constantly strive to protect the information within their DNA from damages posed by a number of factors, such as carbonized materials in our daily food intake, radioactive materials such as radon emitting from the cement of buildings or ultraviolet of the sunlight, which could be a trigger for cancer.
In order to keep the DNA information safe, the organisms are always carrying out complex and sophisticated DNA repair work, which involves the crucial DNA damage repair protein ATM. Consequently, a faulty ATM leads to higher risks of cancer.
Until now, academia predicted that the Translationally Controlled Tumor Protein (TCTP) will play an important role in regulating the function of ATM. However, since most of main research regarding TCTP has only been conducted in cultured cells, it was unable to identify exactly what mechanisms TCTP employs to control ATM.
The KAIST research team identified that TCTP can combine with ATM or increase the enzymatic activity of ATM. In addition, Drosophilia, one of the most widely used model organisms for molecular genetics, has been used to identify that TCTP and ATM play a very important role in repairing the DNA damaged by radiation. This information has allowed the researchers to establish TCTP’s essential function in maintaining the DNA information in cell cultures and even in higher organisms, and to provide specific and important clues to the regulation of ATM by TCTP.
Professor Kwang-Wook Choi said, “Our research is a good example that basic research using Drosophilia can make important contributions to understanding the process of diseases, such as cancer, and to developing adequate treatment.”
The research has been funded by the Ministry of Science, ICT and Future Planning, Republic of Korea, and the National Research Foundation of Korea.
Figure 1. When the amount of TCTP protein is reduced, cells of the Drosophila's eye are abnormally deformed by radiation. Scale bars = 200mm
Figure 2. When the amount of TCTP protein is reduced, the chromosomes of Drosophilia are easily broken by radiation. Scale bars = 10 mm.
Figure 3. When gene expressions of TCTP and ATM are reduced, large defects occur in the normal development of the eye. (Left: normal Drosophilia's eye, right: development-deficient eye)
Figure 4. ATM marks the position of the broken DNA, with TCTP helping to facilitate this reaction. DNA (blue line) within the cell nucleus is coiled around the histone protein (green cylinder). When DNA is broken, ATM protein attaches a phosphate group (P). Multiple DNA repair protein recognizes the phosphate as a signal that requires repair and gathers at the site.
2014.01.07 View 11769 -
New Year's Greeting Ceremony Held on January 2nd
The year 2014 is the Year of the Wooden Horse in Chinese astrology: A dynamic (Horse) and prosperous (Wood) New Year to all at KAIST!
President Steve Kang hosted a New Year’s greeting ceremony on January 2 nd at an auditorium on campus and gave a keynote speech on major administrative policies and academic programs to take effect for the year 2014. K-Valley and End-Run projects, as well as a review of efforts to decentralize the academic system in order to grant colleges and departments more autonomy in their operation of education and research programs were among the few discussed.
The K-Valley project will help KAIST and its neighboring research complex, the Daedeok Innopolis, build a leading multi-layered, innovative cluster of startups and new businesses in Korea through close collaborations among university, research institutes, and industry. The End-Run is a project to attract global investors and companies to Korea that will capitalize on the highest quality talents and technologies developed by KAIST.
President Steve Kang said that he would continue the last year’s campaign to make the campus “happier” throughout this year, encouraging members of the KAIST community to trust and respect and communicate better with each other.
2014.01.07 View 6700 -
Professor Yong-Hee Lee of Physics Received the Humboldt Research Award
In recognition of his past accomplishments in research and teaching, Professor Yong-Hee Lee of Physics at KAIST received the Humboldt Research Award in November 2013. The Humboldt Research Award is annually given by the Alexander von Humboldt Foundation to internationally renowned scientists and scholars in the fields of biology, chemistry, computer science, economics, linguistics, management, mathematics, medicine, philosophy, and physics. The winners of the award are offered with 60,000 Euros of research grant as well as an opportunity to undertake prolonged periods of research in collaboration with researchers in Germany.Professor Lee, who may be the first Korean physicist receiving the award, plans to conduct joint research with colleagues at the Technical University of Berlin and University of Würzburg.
2014.01.05 View 7886 -
Professor Dong-Yol Yang received an award for scholar of the year 2013 from the Korean mechanical engineering community
Professor Dong-Yol Yang from the Department of Mechanical Engineering at KAIST was selected as “the scholar of the year 2013” at an annual event held by the Korean Federation of Mechanical Engineering Societies, the Korea Association of Machinery Industry, and other mechanical engineering research institutes in Korea. The event, the Day of the Machines, is the nation’s biggest gathering for engineers, scholars, and researchers in mechanical engineering, at which winners of the awards for the person of the year in academia, business, and engineering are announced.
Professor Yang was chosen for his lifetime achievement as a scholar in the field of three-dimensional shape precision processing by developing an innovative processing technology that contributes to the advancement of mechanical engineering and industry. He also introduced the three-dimensional fast processing to Korea from 1990 and developed world-class subminiature fast processing, the first of its kind in Korea.In 2013, Professor Yang identified geometric deformation elements in mechanical engineering for the first time in the world, an essential component for nano mobile system and received the best conference paper award at the 3M-Nano International Conference.
2014.01.05 View 8416 -
Professor Dong-Soo Han received the Prime Minister's award for creative economy in 2013
The 2013 Korea Creative Economy Awards, presented to companies or individuals that contributed to the implementation of the Korean government’s economic growth initiative called “creative economy” with the development of new technology, was held on December 12th at the InterContinental Seoul Coex. Professor Dong-Soo Han from the Department of Computer Science at KAIST received the Prime Minister’s award.
Professor Han was recognized for his research accomplishments on the development of an indoor GPS system and an integrated indoor/outdoor navigation system, as well as for his publication of a book for beginners who are interested in patents. He has applied 50 patents and registered 30 patents in Korea and abroad for the indoor positioning technology and smartphone application services.
His research work was also introduced to the public at the exhibition held after the award ceremony during December 12th-15th at the Coex convention center in Seoul.
2014.01.05 View 7429 -
Professor Jin-Hyung Kim appointed as the founding director of the Software Policy Research Center
Professor Jin-Hyung Kim from the Department of Computer Science at KAIST was appointed as the founding director of the newly established research institute, the Software Policy Research Center. He will serve as director for three years. The research center will undertake studies and analysis on software policy, statistics, and new software technology.
2014.01.05 View 7724 -
Professor Kwy-Ro Lee Appointed Distinguished Member of IEEE
Professor Kwy-Ro Lee from the Department of Electrical Engineering at KAIST was selected as a distinguished member of the Institute of Electrical and Electronics Engineers (IEEE) where his contribution to research development of the technological management of semiconductors was recognized.
Professor Lee earned his BS from Seoul National University and MS & Ph.D. from the University of Minnesota. He has been working as a professor in the Department of Electrical Engineering since 1986. He has also served as the president of the LG Electronics Research Center in 2005 and the president of the Nanoscience and Technology Center at KAIST in 2010.
IEEE is the largest professional association for the advancement of technology in electrical, electronics, computing and communication with 400,000 members in 160 countries. Only 0.1 percent of members with over ten years of service can be selected as distinguished members based on their research devotion for society.
2014.01.02 View 7534 -
Professor Jung-Ro Yoon Appointed President of Korean Sociological Association
The Korean Sociological Association (KSA) announced that Professor Jung-Ro Yoon from the Department of Humanities and Social Science at KAIST has been appointed as the president of KSA.
KSA has been contributing in the development of sociology and academic exchange among its members as the largest academic association in the field of social science in Korea since 1957.
Professor Yoon said, “KSA is trying to contribute to finding new solutions for economic crises, inequality, environmental pollution, and other uncertainties that we have been facing. We will attempt to provide vision and hope for the future of the society with cooperation from both students and researchers under the motto ‘Sociology for Research, Play and Communication.’”
Dr. Yoon has been in the Department of Humanities and Social Science at KAIST since 1991 after earning her MA & Ph.D. degree from Harvard University. She introduced Science, Technology and Society (STS) into Korea and served as the leader of the Ethical, Legal and Social Implications (ELSI) Project for the Utilization of Human Genome Information.
2014.01.02 View 7846 -
Freshmen join a volunteer program to assist people in need
“Learning how to share love is the first step to start a good, meaningful college life,” said President Steve Kang.
KAIST offers an opportunity to all freshmen entering KAIST in 2014 to participate in a volunteer program to help people in need. Under the program, about 800 students will visit a shelter for the homeless, senior citizens, and orphans, which is called “The Flower Town” located two hours away from KAIST campus.
The town was founded by a Catholic organization, “The Flower Town Preservation Foundation,” to provide housing, education, and health services to the most vulnerable and neglected populations in our society.
President Steve Kang and Woong-Jin Oh, the president of the foundation, made a partnership agreement to promote volunteerism and spread the spirit of sharing and caring among young people, including KAIST students. The participating students will stay at the shelter for a few days and engage in various volunteering activities such as serving meals, cleaning, playing with children, and teaching.
President Kang said, “I am very happy that we are able to give our students a chance to develop into warm-hearted people. Scientists without a heart may bring about modern conveniences but not necessarily the betterment of humanity. Learning how to share love is the first step to start a good, meaningful college life.”
2013.12.30 View 5693 -
KAIST Student Awarded Prize from Energy Saving Contest
Jun-Min Kwon, an undergraduate student in the Department of Chemistry at KAIST, was awarded a prize from the Ministry of Trade, Industry and Energy, Republic of Korea, at the 35th Energy Saving Contest which was held on November 20.
The student club he has been leading was also selected as one of the best groups by the Save Energy Save Earth (SESE), a volunteer organization supported by the Korea Energy Management Corporation and the Ministry of Knowledge Economy, Republic of Korea.
Kwon began promoting energy conservation through a blog and participated in related meetings and workshops as a high school student to improve the understanding on the importance of energy saving and recycling.He also received awards from the Second National Assembly Forum on Climate Change, the Korean National Science Fair, as well as the Samsung Human Tech Paper Award.
2013.12.24 View 10784 -
Professor Suk-Joo Na Invited to Finland as Distinguished Professor
Professor Suk-Joo Na, from the Department of Mechanical Engineering at KAIST, has been invited as a distinguished professor for an international research project in Finland.
As a leading scientist in the field of arc welding and numerical analysis of the laser welding process, Na will assemble a research group for the interpretation of the welding processes for three years at the VVT Technical Research Centre of Finland beginning in January of 2014.
The project was established to improve the research level and national competitiveness of Finland by inviting leading international scientists to the National Technology Agency of Finland and Academy of Finland since 2006 and over one hundred projects have been carried out thus far. A total of 17 billion won will be invested for the eleven new projects selected this year. Professor Na said, “The fusion welding field contains important technology for improving the competitiveness of mechanical products of Finland. Improvements in productivity, the life cycles of products, and energy saving through interpretation technology for the numerical analysis of the welding process will make a huge impact on the national economy of Finland.”
2013.12.24 View 8708 -
Nanoparticle based Super Lens selected as 2013 Science and Technology News
Professor Yong-keun Park
"Nanoparticle-based Super Lens", an article by KAIST Physics Department’s Professor Yong-keun Park and Professor Yong-hoon Cho’s joint research team, has been selected as one of the ten representative 2013 Science and Technology News, by the Korea Federation of Science and Technology Societies.
This new concept super lens uses the scattering of light, which can yield over three times more superior resolution of previous optical lenses.
Unlike the conventional optical lens that utilizes refraction of the light, the super lens can give the image of viruses and structure within the cell at 100㎚. This lens is also applicable to state-of-the-art optical and semiconductor processes.
In addition, this year's research achievements also include the successful launch of Naro, a new technology to remove the brain cell membrane which gives a more transparent view of the brain, a new drug to inhibit cancer metastasis, as well as the development of ultra-wide-angle insect eye camera technology.
Articles for 2013 Science and Technology News are chosen in three trial reviews by committee and online voting by 5,437 people over the course of [two weeks]14 days, from November 21st to December 4th.
2013.12.14 View 9410