Korean+Ministry+of+Education
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Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 11956 -
Super-Fast Internet Data Chip Developed
A KAIST research team led by Prof. Kyoung-Hoon Yang of the Electrical Engineering & Computer Science Department developed a super-fast chip that could lead to huge advancements in broadband Internet technology, the Korean Ministry of Education, Science and Technology said on Thursday (June 26).
The multiplexer chip is the first of its kind to be developed using the quantum effect of resonant tunnelling diode, according to the Ministry.
The integrated circuit chip built at the university laboratory has an operating speed of 45 gigabits per second (Gb/s), while using roughly 75 percent less energy than the previous version. The speed enables the transfer of about 4 full-length movies in one second.
The best operational broadband Internet services provide users with data transfer speed of 40 Gb/s, while most other high-speed online connections offer 10 Gb/s.
"Besides speed, the greatest achievement is low energy use," Prof. Yang said. He stressed that energy use in chips is a crucial factor because power creates heat that can melt circuits and make them inoperable.
"By cutting down on energy use, the new chips can be made smaller and with faster data transfer speed," the scientist said.
He added that efforts are underway to increase operational speed to 100 Gb/s, with energy consumption to be cut to 10 percent of current chips like the high electron mobility transistor, the heterojunction bipolar transistor and the complementary metal oxide semiconductor.
The researcher speculated that such revolutionary chips could be developed in 1-2 years and become the new benchmark in this field since existing chips have limited development capabilities.
The project has received funding from the Education-Science-Technology Ministry since 2000. The Ministry"s financial support will last until 2010.
2008.06.26 View 12290