report
-
KAIST Demonstrates AI and sustainable technologies at CES 2024
On January 2, KAIST announced it will be participating in the Consumer Electronics Show (CES) 2024, held between January 9 and 12.
CES 2024 is one of the world’s largest tech conferences to take place in Las Vegas. Under the slogan “KAIST, the Global Value Creator” for its exhibition, KAIST has submitted technologies falling under one of following themes: “Expansion of Human Intelligence, Mobility, and Reality”, and “Pursuit of Human Security and Sustainable Development”.
24 startups and pre-startups whose technologies stand out in various fields including artificial intelligence (AI), mobility, virtual reality, healthcare and human security, and sustainable development, will welcome their visitors at an exclusive booth of 232 m2 prepared for KAIST at Eureka Park in Las Vegas.
12 businesses will participate in the first category, “Expansion of Human Intelligence, Mobility, and Reality”, including MicroPix, Panmnesia, DeepAuto, MGL, Reports, Narnia Labs, EL FACTORY, Korea Position Technology, AudAi, Planby Technologies, Movin, and Studio Lab.
In the “Pursuit of Human Security and Sustainable Development” category, 12 businesses including Aldaver, ADNC, Solve, Iris, Blue Device, Barreleye, TR, A2US, Greeners, Iron Boys, Shard Partners and Kingbot, will be introduced.
In particular, Aldaver is a startup that received the Korean Business Award 2023 as well as the presidential award at the Challenge K-Startup with its biomimetic material and printing technology. It has attracted 4.5 billion KRW of investment thus far.
Narnia Labs, with its AI design solution for manufacturing, won the grand prize for K-tech Startups 2022, and has so far attracted 3.5 billion KRW of investments.
Panmnesia is a startup that won the 2024 CES Innovation Award, recognized for their fab-less AI semiconductor technology. They attracted 16 billion KRW of investment through seed round alone.
Meanwhile, student startups will also be presented during the exhibition. Studio Lab received a CES 2024 Best of Innovation Award in the AI category. The team developed the software Seller Canvas, which automatically generates a page for product details when a user uploads an image of a product.
The central stage at the KAIST exhibition booth will be used to interview members of the participating startups between Jan 9 to 11, as well as a networking site for businesses and invited investors during KAIST NIGHT on the evening of 10th, between 5 and 7 PM.
Director Sung-Yool Choi of the KAIST Institute of Technology Value Creation said, “Through CES 2024, KAIST will overcome the limits of human intelligence, mobility, and space with the deep-tech based technologies developed by its startups, and will demonstrate its achievements for realizing its vision as a global value-creating university through the solutions for human security and sustainable development.”
2024.01.05 View 5156 -
KAIST researchers find sleep delays more prevalent in countries of particular culture than others
Sleep has a huge impact on health, well-being and productivity, but how long and how well people sleep these days has not been accurately reported. Previous research on how much and how well we sleep has mostly relied on self-reports or was confined within the data from the unnatural environments of the sleep laboratories.
So, the questions remained: Is the amount and quality of sleep purely a personal choice? Could they be independent from social factors such as culture and geography?
< From left to right, Sungkyu Park of Kangwon National University, South Korea; Assem Zhunis of KAIST and IBS, South Korea; Marios Constantinides of Nokia Bell Labs, UK; Luca Maria Aiello of the IT University of Copenhagen, Denmark; Daniele Quercia of Nokia Bell Labs and King's College London, UK; and Meeyoung Cha of IBS and KAIST, South Korea >
A new study led by researchers at Korea Advanced Institute of Science and Technology (KAIST) and Nokia Bell Labs in the United Kingdom investigated the cultural and individual factors that influence sleep. In contrast to previous studies that relied on surveys or controlled experiments at labs, the team used commercially available smartwatches for extensive data collection, analyzing 52 million logs collected over a four-year period from 30,082 individuals in 11 countries. These people wore Nokia smartwatches, which allowed the team to investigate country-specific sleep patterns based on the digital logs from the devices.
< Figure comparing survey and smartwatch logs on average sleep-time, wake-time, and sleep durations. Digital logs consistently recorded delayed hours of wake- and sleep-time, resulting in shorter sleep durations. >
Digital logs collected from the smartwatches revealed discrepancies in wake-up times and sleep-times, sometimes by tens of minutes to an hour, from the data previously collected from self-report assessments. The average sleep-time overall was calculated to be around midnight, and the average wake-up time was 7:42 AM. The team discovered, however, that individuals' sleep is heavily linked to their geographical location and cultural factors. While wake-up times were similar, sleep-time varied by country. Individuals in higher GDP countries had more records of delayed bedtime. Those in collectivist culture, compared to individualist culture, also showed more records of delayed bedtime. Among the studied countries, Japan had the shortest total sleep duration, averaging a duration of under 7 hours, while Finland had the longest, averaging 8 hours.
Researchers calculated essential sleep metrics used in clinical studies, such as sleep efficiency, sleep duration, and overslept hours on weekends, to analyze the extensive sleep patterns. Using Principal Component Analysis (PCA), they further condensed these metrics into two major sleep dimensions representing sleep quality and quantity. A cross-country comparison revealed that societal factors account for 55% of the variation in sleep quality and 63% of the variation in sleep quantity.
Countries with a higher individualism index (IDV), which placed greater emphasis on individual achievements and relationships, had significantly longer sleep durations, which could be attributed to such societies having a norm of going to bed early. Spain and Japan, on the other hand, had the bedtime scheduled at the latest hours despite having the highest collectivism scores (low IDV). The study also discovered a moderate relationship between a higher uncertainty avoidance index (UAI), which measures implementation of general laws and regulation in daily lives of regular citizens, and better sleep quality.
Researchers also investigated how physical activity can affect sleep quantity and quality to see if individuals can counterbalance cultural influences through personal interventions. They discovered that increasing daily activity can improve sleep quality in terms of shortened time needed in falling asleep and waking up. Individuals who exercise more, however, did not sleep longer. The effect of exercise differed by country, with more pronounced effects observed in some countries, such as the United States and Finland. Interestingly, in Japan, no obvious effect of exercise could be observed. These findings suggest that the relationship between daily activity and sleep may differ by country and that different exercise regimens may be more effective in different cultures.
This research published on the Scientific Reports by the international journal, Nature, sheds light on the influence of social factors on sleep. (Paper Title "Social dimensions impact individual sleep quantity and quality" Article number: 9681)
One of the co-authors, Daniele Quercia, commented: “Excessive work schedules, long working hours, and late bedtime in high-income countries and social engagement due to high collectivism may cause bedtimes to be delayed.”
Commenting on the research, the first author Shaun Sungkyu Park said, "While it is intriguing to see that a society can play a role in determining the quantity and quality of an individual's sleep with large-scale data, the significance of this study is that it quantitatively shows that even within the same culture (country), individual efforts such as daily exercise can have a positive impact on sleep quantity and quality."
"Sleep not only has a great impact on one’s well-being but it is also known to be associated with health issues such as obesity and dementia," said the lead author, Meeyoung Cha. "In order to ensure adequate sleep and improve sleep quality in an aging society, not only individual efforts but also a social support must be provided to work together," she said. The research team will contribute to the development of the high-tech sleep industry by making a code that easily calculates the sleep indicators developed in this study available free of charge, as well as providing the benchmark data for various types of sleep research to follow.
2023.07.07 View 4868 -
‘Urban Green Space Affects Citizens’ Happiness’
Study finds the relationship between green space, the economy, and happiness
A recent study revealed that as a city becomes more economically developed, its citizens’ happiness becomes more directly related to the area of urban green space.
A joint research project by Professor Meeyoung Cha of the School of Computing and her collaborators studied the relationship between green space and citizen happiness by analyzing big data from satellite images of 60 different countries.
Urban green space, including parks, gardens, and riversides not only provides aesthetic pleasure, but also positively affects our health by promoting physical activity and social interactions. Most of the previous research attempting to verify the correlation between urban green space and citizen happiness was based on few developed countries. Therefore, it was difficult to identify whether the positive effects of green space are global, or merely phenomena that depended on the economic state of the country. There have also been limitations in data collection, as it is difficult to visit each location or carry out investigations on a large scale based on aerial photographs.
The research team used data collected by Sentinel-2, a high-resolution satellite operated by the European Space Agency (ESA) to investigate 90 green spaces from 60 different countries around the world. The subjects of analysis were cities with the highest population densities (cities that contain at least 10% of the national population), and the images were obtained during the summer of each region for clarity. Images from the northern hemisphere were obtained between June and September of 2018, and those from the southern hemisphere were obtained between December of 2017 and February of 2018.
The areas of urban green space were then quantified and crossed with data from the World Happiness Report and GDP by country reported by the United Nations in 2018. Using these data, the relationships between green space, the economy, and citizen happiness were analyzed.
The results showed that in all cities, citizen happiness was positively correlated with the area of urban green space regardless of the country’s economic state. However, out of the 60 countries studied, the happiness index of the bottom 30 by GDP showed a stronger correlation with economic growth. In countries whose gross national income (GDP per capita) was higher than 38,000 USD, the area of green space acted as a more important factor affecting happiness than economic growth. Data from Seoul was analyzed to represent South Korea, and showed an increased happiness index with increased green areas compared to the past.
The authors point out their work has several policy-level implications. First, public green space should be made accessible to urban dwellers to enhance social support. If public safety in urban parks is not guaranteed, its positive role in social support and happiness may diminish. Also, the meaning of public safety may change; for example, ensuring biological safety will be a priority in keeping urban parks accessible during the COVID-19 pandemic.
Second, urban planning for public green space is needed for both developed and developing countries. As it is challenging or nearly impossible to secure land for green space after the area is developed, urban planning for parks and green space should be considered in developing economies where new cities and suburban areas are rapidly expanding.
Third, recent climate changes can present substantial difficulty in sustaining urban green space. Extreme events such as wildfires, floods, droughts, and cold waves could endanger urban forests while global warming could conversely accelerate tree growth in cities due to the urban heat island effect. Thus, more attention must be paid to predict climate changes and discovering their impact on the maintenance of urban green space.
“There has recently been an increase in the number of studies using big data from satellite images to solve social conundrums,” said Professor Cha. “The tool developed for this investigation can also be used to quantify the area of aquatic environments like lakes and the seaside, and it will now be possible to analyze the relationship between citizen happiness and aquatic environments in future studies,” she added.
Professor Woo Sung Jung from POSTECH and Professor Donghee Wohn from the New Jersey Institute of Technology also joined this research. It was reported in the online issue of EPJ Data Science on May 30.
-PublicationOh-Hyun Kwon, Inho Hong, Jeasurk Yang, Donghee Y. Wohn, Woo-Sung Jung, andMeeyoung Cha, 2021. Urban green space and happiness in developed countries. EPJ Data Science. DOI: https://doi.org/10.1140/epjds/s13688-021-00278-7
-ProfileProfessor Meeyoung ChaData Science Labhttps://ds.ibs.re.kr/
School of Computing
KAIST
2021.06.21 View 9275 -
Research Day Highlights the Most Impactful Technologies of the Year
Technology Converting Full HD Image to 4-Times Higher UHD Via Deep Learning Cited as the Research of the Year
The technology converting a full HD image into a four-times higher UHD image in real time via AI deep learning was recognized as the Research of the Year. Professor Munchurl Kim from the School of Electrical Engineering who developed the technology won the Research of the Year Grand Prize during the 2021 KAIST Research Day ceremony on May 25. Professor Kim was lauded for conducting creative research on machine learning and deep learning-based image processing.
KAIST’s Research Day recognizes the most notable research outcomes of the year, while creating opportunities for researchers to immerse themselves into interdisciplinary research projects with their peers. The ceremony was broadcast online due to Covid-19 and announced the Ten R&D Achievement of the Year that are expected to make a significant impact.
To celebrate the award, Professor Kim gave a lecture on “Computational Imaging through Deep Learning for the Acquisition of High-Quality Images.” Focusing on the fact that advancements in artificial intelligence technology can show superior performance when used to convert low-quality videos to higher quality, he introduced some of the AI technologies that are currently being applied in the field of image restoration and quality improvement.
Professors Eui-Cheol Shin from the Graduate School of Medical Science and Engineering and In-Cheol Park from the School of Electrical Engineering each received Research Awards, and Professor Junyong Noh from the Graduate School of Culture Technology was selected for the Innovation Award. Professors Dong Ki Yoon from the Department of Chemistry and Hyungki Kim from the Department of Mechanical Engineering were awarded the Interdisciplinary Award as a team for their joint research.
Meanwhile, out of KAIST’s ten most notable R&D achievements, those from the field of natural and biological sciences included research on rare earth element-platinum nanoparticle catalysts by Professor Ryong Ryoo from the Department of Chemistry, real-time observations of the locational changes in all of the atoms in a molecule by Professor Hyotcherl Ihee from the Department of Chemistry, and an investigation on memory retention mechanisms after synapse removal from an astrocyte by Professor Won-Suk Chung from the Department of Biological Sciences.
Awardees from the engineering field were a wearable robot for paraplegics with the world’s best functionality and walking speed by Professor Kyoungchul Kong from the Department of Mechanical Engineering, fair machine learning by Professor Changho Suh from the School of Electrical Engineering, and a generative adversarial networks processing unit (GANPU), an AI semiconductor that can learn from even mobiles by processing multiple and deep networks by Professor Hoi-Jun Yoo from the School of Electrical Engineering.
Others selected as part of the ten research studies were the development of epigenetic reprogramming technology in tumour by Professor Pilnam Kim from the Department of Bio and Brain Engineering, the development of an original technology for reverse cell aging by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering, a heterogeneous metal element catalyst for atmospheric purification by Professor Hyunjoo Lee from the Department of Chemical and Biomolecular Engineering, and the Mobile Clinic Module (MCM): a negative pressure ward for epidemic hospitals by Professor Taek-jin Nam (reported at the Wall Street Journal) from the Department of Industrial Design.
2021.05.31 View 12607 -
Attachable Skin Monitors that Wick the Sweat Away
- A silicone membrane for wearable devices is more comfortable and breathable thanks to better-sized pores made with the help of citric acid crystals. -
A new preparation technique fabricates thin, silicone-based patches that rapidly wick water away from the skin. The technique could reduce the redness and itching caused by wearable biosensors that trap sweat beneath them. The technique was developed by bioengineer and professor Young-Ho Cho and his colleagues at KAIST and reported in the journal Scientific Reports last month.
“Wearable bioelectronics are becoming more attractive for the day-to-day monitoring of biological compounds found in sweat, like hormones or glucose, as well as body temperature, heart rate, and energy expenditure,” Professor Cho explained. “But currently available materials can cause skin irritation, so scientists are looking for ways to improve them,” he added.
Attachable biosensors often use a silicone-based compound called polydimethylsiloxane (PDMS), as it has a relatively high water vapour transmission rate compared to other materials. Still, this rate is only two-thirds that of skin’s water evaporation rate, meaning sweat still gets trapped underneath it.
Current fabrication approaches mix PDMS with beads or solutes, such as sugars or salts, and then remove them to leave pores in their place. Another technique uses gas to form pores in the material. Each technique has its disadvantages, from being expensive and complex to leaving pores of different sizes.
A team of researchers led by Professor Cho from the KAIST Department of Bio and Brain Engineering was able to form small, uniform pores by crystallizing citric acid in PDMS and then removing the crystals using ethanol. The approach is significantly cheaper than using beads, and leads to 93.2% smaller and 425% more uniformly-sized pores compared to using sugar. Importantly, the membrane transmits water vapour 2.2 times faster than human skin.
The team tested their membrane on human skin for seven days and found that it caused only minor redness and no itching, whereas a non-porous PDMS membrane did.
Professor Cho said, “Our method could be used to fabricate porous PDMS membranes for skin-attachable devices used for daily monitoring of physiological signals.”
“We next plan to modify our membrane so it can be more readily attached to and removed from skin,” he added.
This work was supported by the Ministry of Trade, Industry and Energy (MOTIE) of Korea under the Alchemist Project.
Image description:
Smaller, more uniformly-sized pores are made in the PDMS membrane by mixing PDMS, toluene, citric acid, and ethanol. Toluene dilutes PDMS so it can easily mix with the other two constituents. Toluene and ethanol are then evaporated, which causes the citric acid to crystallize within the PDMS material. The mixture is placed in a mould where it solidifies into a thin film. The crystals are then removed using ethanol, leaving pores in their place.
Image credit:
Professor Young-Ho Cho, KAIST
Image usage restrictions:
News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Yoon, S, et al. (2021) Wearable porous PDMS layer of high moisture permeability for skin trouble reduction. Scientific Reports 11, Article No. 938. Available online at https://doi.org/10.1038/s41598-020-78580-z
Profile:
Young-Ho Cho, Ph.D
Professor
mems@kaist.ac.kr
https://mems.kaist.ac.kr
NanoSentuating Systems Laboratory
Department of Bio and Brain Engineering
https://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
(END)
2021.02.22 View 10899 -
Ushering in a New Era at the 50th Innoversary Ceremony
President Moon Jae-In declares KAIST the future of Korea
KAIST reaffirmed its goal of becoming an institute that can serve the world for the next century, marking its 50th anniversary on February 16. The KAIST community and distinguished guests gathered online during the official ceremony to commemorate KAIST’s anniversary and envisioned ways to serve the world, a major shift from its founding mission focusing on national growth.
The ceremony celebrated the legacy of KAIST, which has become a trailblazer by fostering the most competent scientists and engineers and making breakthroughs which led to the nation becoming a global high-tech leader.
President Moon Jae-In applauded KAIST as “the future of Korea” in his online congratulatory message, saying that “KAIST has made us feel proud when the nation stays ahead in science and technology. The dream of KAIST has been the dream of Korea. The passion of KAIST has been the passion of Korea. KAIST is the future of Korea.”
“KAIST has overcome challenges and created innovations for advancing the nation, from the first internet network to launching our first satellite in the early 80s to the Mobile Clinic Module (MCM), a negative pressure ward module in response to COVID-19. Whenever the nation faced a challenge, KAIST was there.”
President Moon also asked KAIST researchers to find sustainable ways to balance nature and humanity in this time of climate change and the Fourth Industrial Revolution.
Executive Chairman of the World Economic Forum Dr.Klaus Schwab also congratulated, saying "KAIST is a leader in ensuring social inclusion. Founded with the support of USAID, today it is paying it forward and sharing the same support through the Kenya-KAIST project."
The ceremony first brought Dr. KunMo Chung to the stage, the man who proposed the idea of founding the first advanced science and technology institute in Korea. His proposal to the then administrator of USAID John Hannah resulted in the Korean government meriting a 6 million USD loan for to start KAIST. He was the only Korean member of the USAID feasibility study team led by Dr. Frederick Terman, the former vice president of Stanford University. Dr. Chung wrote the Terman Report, which gave a green light to the establishment of KAIST in Korea in 1970.
Dr. Chung said the nation’s strong desire to escape from poverty through the advancement of science and technology was thoroughly realized by KAIST. “The Terman Report’s vision was perfectly realized. Now it’s time to envision the next dream of KAIST for another century.”
President Sung-Chul Shin said in his anniversary speech that KAIST has now transformed into a university that will serve the all of humanity by advancing science and technology while fostering new talents best fit for the new global environment. President Shin said that to fulfill KAIST’s second dream, the university will drive innovation in the five major areas of education, research, technology commercialization, globalization, and future strategy, under the C3 spirit of a Challenging spirit, Creativity, and Caring minds.
“In the next 50 years, KAIST hopes to fulfill the 10-10-10 Dream, that is, to have 10 Singularity Professors who have produced world-class achievements, 10 Decacorn startups valued at 10 trillion won, and global campuses in 10 countries.”
Then, four young KAIST professors who are conducting research in the flagship fields of mobility, new materials, post-AI, and bio-medicine presented their research vision and gave speeches. Professor Hae-Won Park from the Department of Mechanical Engineering and Professor Jihyeon Yeom from the Department of Materials Science and Engineering said the advent of new mobility combined with robotics and new nano-materials scaled down into spintronics, ‘KAISTronic materials’, will provide new momentum for the industry and the wellbeing of humanity. Professor Kijung Shin from the Graduate School of AI spoke on the new future transformed by quantum computers. Professor Young Seok Ju from the Graduate School of Medical Science and Engineering predicted a future in which cancer will no longer be a terminal disease and digital cells and the digitization of bio-medicine will significantly improve our quality of life. He said the combination of anti-aging and reverse aging studies will make a difference in our lives.
After the official ceremony, KAIST’s administrative leadership including President Shin and Dr. Kun-Mo Chung attended a ceremony to dedicate the sky lounge at the Academic Cultural Complex as the John Hannah Hall. Terman Hall, located in the Creative Learning Building, was dedicated in 2004 in honor of Dr. Frederick Terman.
2021.02.17 View 11069 -
Unravelling Complex Brain Networks with Automated 3-D Neural Mapping
-Automated 3-D brain imaging data analysis technology offers more reliable and standardized analysis of the spatial organization of complex neural circuits.-
KAIST researchers developed a new algorithm for brain imaging data analysis that enables the precise and quantitative mapping of complex neural circuits onto a standardized 3-D reference atlas.
Brain imaging data analysis is indispensable in the studies of neuroscience. However, analysis of obtained brain imaging data has been heavily dependent on manual processing, which cannot guarantee the accuracy, consistency, and reliability of the results.
Conventional brain imaging data analysis typically begins with finding a 2-D brain atlas image that is visually similar to the experimentally obtained brain image. Then, the region-of-interest (ROI) of the atlas image is matched manually with the obtained image, and the number of labeled neurons in the ROI is counted.
Such a visual matching process between experimentally obtained brain images and 2-D brain atlas images has been one of the major sources of error in brain imaging data analysis, as the process is highly subjective, sample-specific, and susceptible to human error. Manual analysis processes for brain images are also laborious, and thus studying the complete 3-D neuronal organization on a whole-brain scale is a formidable task.
To address these issues, a KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering developed new brain imaging data analysis software named 'AMaSiNe (Automated 3-D Mapping of Single Neurons)', and introduced the algorithm in the May 26 issue of Cell Reports.
AMaSiNe automatically detects the positions of single neurons from multiple brain images, and accurately maps all the data onto a common standard 3-D reference space. The algorithm allows the direct comparison of brain data from different animals by automatically matching similar features from the images, and computing the image similarity score.
This feature-based quantitative image-to-image comparison technology improves the accuracy, consistency, and reliability of analysis results using only a small number of brain slice image samples, and helps standardize brain imaging data analyses.
Unlike other existing brain imaging data analysis methods, AMaSiNe can also automatically find the alignment conditions from misaligned and distorted brain images, and draw an accurate ROI, without any cumbersome manual validation process.
AMaSiNe has been further proved to produce consistent results with brain slice images stained utilizing various methods including DAPI, Nissl, and autofluorescence.
The two co-lead authors of this study, Jun Ho Song and Woochul Choi, exploited these benefits of AMaSiNe to investigate the topographic organization of neurons that project to the primary visual area (VISp) in various ROIs, such as the dorsal lateral geniculate nucleus (LGd), which could hardly be addressed without proper calibration and standardization of the brain slice image samples.
In collaboration with Professor Seung-Hee Lee's group of the Department of Biological Science, the researchers successfully observed the 3-D topographic neural projections to the VISp from LGd, and also demonstrated that these projections could not be observed when the slicing angle was not properly corrected by AMaSiNe. The results suggest that the precise correction of a slicing angle is essential for the investigation of complex and important brain structures.
AMaSiNe is widely applicable in the studies of various brain regions and other experimental conditions. For example, in the research team’s previous study jointly conducted with Professor Yang Dan’s group at UC Berkeley, the algorithm enabled the accurate analysis of the neuronal subsets in the substantia nigra and their projections to the whole brain. Their findings were published in Science on January 24.
AMaSiNe is of great interest to many neuroscientists in Korea and abroad, and is being actively used by a number of other research groups at KAIST, MIT, Harvard, Caltech, and UC San Diego.
Professor Paik said, “Our new algorithm allows the spatial organization of complex neural circuits to be found in a standardized 3-D reference atlas on a whole-brain scale. This will bring brain imaging data analysis to a new level.”
He continued, “More in-depth insights for understanding the function of brain circuits can be achieved by facilitating more reliable and standardized analysis of the spatial organization of neural circuits in various regions of the brain.”
This work was supported by KAIST and the National Research Foundation of Korea (NRF).
Figure and Image Credit: Professor Se-Bum Paik, KAIST
Figure and Image Usage Restrictions: News organizations may use or redistribute these figures and images, with proper attribution, as part of news coverage of this paper only.
Publication:
Song, J. H., et al. (2020). Precise Mapping of Single Neurons by Calibrated 3D Reconstruction of Brain Slices Reveals Topographic Projection in Mouse Visual Cortex. Cell Reports. Volume 31, 107682. Available online at https://doi.org/10.1016/j.celrep.2020.107682
Profile:
Se-Bum Paik
Assistant Professor
sbpaik@kaist.ac.kr
http://vs.kaist.ac.kr/
VSNN Laboratory
Department of Bio and Brain Engineering
Program of Brain and Cognitive Engineering
http://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
(END)
2020.06.08 View 11862 -
A Single Biological Factor Predicts Distinct Cortical Organizations across Mammalian Species
-A KAIST team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization.-
Researchers have explained how visual cortexes develop uniquely across the brains of different mammalian species. A KAIST research team led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering has identified a single biological factor, the retino-cortical mapping ratio, that predicts distinct cortical organizations across mammalian species.
This new finding has resolved a long-standing puzzle in understanding visual neuroscience regarding the origin of functional architectures in the visual cortex. The study published in Cell Reports on March 10 demonstrates that the evolutionary variation of biological parameters may induce the development of distinct functional circuits in the visual cortex, even without species-specific developmental mechanisms.
In the primary visual cortex (V1) of mammals, neural tuning to visual stimulus orientation is organized into one of two distinct topographic patterns across species. While primates have columnar orientation maps, a salt-and-pepper type organization is observed in rodents.
For decades, this sharp contrast between cortical organizations has spawned fundamental questions about the origin of functional architectures in the V1. However, it remained unknown whether these patterns reflect disparate developmental mechanisms across mammalian taxa, or simply originate from variations in biological parameters under a universal development process.
To identify a determinant predicting distinct cortical organizations, Professor Paik and his researchers Jaeson Jang and Min Song examined the exact condition that generates columnar and salt-and-pepper organizations, respectively. Next, they applied a mathematical model to investigate how the topographic information of the underlying retinal mosaics pattern could be differently mapped onto a cortical space, depending on the mapping condition.
The research team proved that the retino-cortical feedforwarding mapping ratio appeared to be correlated to the cortical organization of each species. In the model simulations, the team found that distinct cortical circuitries can arise from different V1 areas and retinal ganglion cell (RGC) mosaic sizes. The team’s mathematical sampling model shows that retino-cortical mapping is a prime determinant in the topography of cortical organization, and this prediction was confirmed by neural parameter analysis of the data from eight phylogenetically distinct mammalian species.
Furthermore, the researchers proved that the Nyquist sampling theorem explains this parametric division of cortical organization with high accuracy. They showed that a mathematical model predicts that the organization of cortical orientation tuning makes a sharp transition around the Nyquist sampling frequency, explaining why cortical organizations can be observed in either columnar or salt-and-pepper organizations, but not in intermediates between these two stages.
Professor Paik said, “Our findings make a significant impact for understanding the origin of functional architectures in the visual cortex of the brain, and will provide a broad conceptual advancement as well as advanced insights into the mechanism underlying neural development in evolutionarily divergent species.”
He continued, “We believe that our findings will be of great interest to scientists working in a wide range of fields such as neuroscience, vision science, and developmental biology.”
This work was supported by the National Research Foundation of Korea (NRF).
Image credit: Professor Se-Bum Paik, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Jaeson Jang, Min Song, and Se-Bum Paik. (2020). Retino-cortical mapping ratio predicts columnar and salt-and-pepper organization in mammalian visual cortex. Cell Reports. Volume 30. Issue 10. pp. 3270-3279. Available online at https://doi.org/10.1016/j.celrep.2020.02.038
Profile:
Se-Bum Paik
Assistant Professor
sbpaik@kaist.ac.kr
http://vs.kaist.ac.kr/
VSNN Laboratory
Department of Bio and Brain Engineering
Program of Brain and Cognitive Engineering
http://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
Profile:
Jaeson Jang
Ph.D. Candidate
jaesonjang@kaist.ac.kr
Department of Bio and Brain Engineering, KAIST
Profile:
Min Song
Ph.D. Candidate
night@kaist.ac.kr
Program of Brain and Cognitive Engineering, KAIST
(END)
2020.03.11 View 11666 -
Improving Traffic Safety with a Crowdsourced Traffic Violation Reporting App
KAIST researchers revealed that crowdsourced traffic violation reporting with smartphone-based continuous video capturing can dramatically change the current practice of policing activities on the road and will significantly improve traffic safety.
Professor Uichin Lee of the Department of Industrial and Systems Engineering and the Graduate School of Knowledge Service Engineering at KAIST and his research team designed and evaluated Mobile Roadwatch, a mobile app that helps citizen record traffic violation with their smartphones and report the recorded videos to the police.
This app supports continuous video recording just like onboard vehicle dashboard cameras. Mobile Roadwatch allows drivers to safely capture traffic violations by simply touching a smartphone screen while driving. The captured videos are automatically tagged with contextual information such as location and time. This information will be used as important evidence for the police to ticket the violators. All of the captured videos can be conveniently reviewed, allowing users to decide which events to report to the police.
The team conducted a two-week field study to understand how drivers use Mobile Roadwatch. They found that the drivers tended to capture all traffic risks regardless of the level of their involvement and the seriousness of the traffic risks. However, when it came to actual reporting, they tended to report only serious traffic violations, which could have led to car accidents, such as traffic signal violations and illegal U-turns. After receiving feedback about their reports from the police, drivers typically felt very good about their contributions to traffic safety.
At the same time, some drivers felt pleased to know that the offenders received tickets since they thought these offenders deserved to be ticketed. While participating in the Mobile Roadwatch campaign, drivers reported that they tried to drive as safely as possible and abide by traffic laws. This was because they wanted to be as fair as possible so that they could capture others’ violations without feeling guilty. They were also afraid that other drivers might capture their violations.
Professor Lee said, “Our study participants answered that Mobile Roadwatch served as a very useful tool for reporting traffic violations, and they were highly satisfied with its features. Beyond simple reporting, our tool can be extended to support online communities, which help people actively discuss various local safety issues and work with the police and local authorities to solve these safety issues.”
Korea and India were the early adaptors supporting video-based reporting of traffic violations to the police. In recent years, the number of reports has dramatically increased. For example, Korea’s ‘Looking for a Witness’ (released in April 2015) received more than half million reported violations as of November 2016. In the US, authorities started tapping into smartphone recordings by releasing video-based reporting apps such as ICE Blackbox and Mobile Justice. Professor Lee said that the existing services cannot be used while driving, because none of the existing services support continuous video recording and safe event capturing behind the wheel.
Professor Lee’s team has been incorporating advanced computer vision techniques into Mobile Roadwatch for automatically capturing traffic violations and safety risks, including potholes and obstacles. The researchers will present their results in May at the ACM CHI Conference on Human Factors in Computing Systems (CHI 2017) in Denver, CO, USA. Their research was supported by the KAIST-KUSTAR fund.
(Caption: A driver is trying to capture an event by touching a screen. The Mobile Radwatch supports continuous video recording and safe event captureing behind the wheel.)
2017.04.10 View 9777 -
ISCN and GULF Share Best Practices Report
The International Sustainable Campus Network (ISCN) and the Global University Leaders Forum (GULF) co-hosted a conference at the 2016 World Economic Forum held on January 20-23, 2016 in Davos, Switzerland, to present exemplary campus sustainability case studies provided by the world’s leading universities.
A total of 20 universities, including KAIST, Harvard University, University of Oxford, Yale University, the National University of Singapore, the Hong Kong University of Science and Technology, and the Swiss Federal Institute of Technology (Zurich), reported on their endeavors to demonstrate sustainable development in higher education in three different panels at the conference: Developing Skills and Building Capacities, Collaborating to Catalyze Change, and Innovating for Efficient Built Environments.
President Sung-Mo Kang of KAIST gave a presentation on the Saudi Aramco-KAIST CO2 Management Center as a sustainable development model for KAIST.
KAIST and Saudi Aramco, the world’s leading fossil-fuel provider, joined forces in 2013 to establish a joint research center on the reduction and management of carbon dioxide (CO2) emissions, a major driver of climate change.
The research center, located at the KAIST campus in Daejeon, South Korea, is currently sponsoring ten research projects involving more than 20 doctoral-level researchers and over 100 students.
The goal of the center is to develop materials for more energy-efficient CO2 capture, catalysts and processes for converting CO2 into valuable products, novel storage methods, and system-level analyses of major CO2 emitting industries to suggest industry-specific CO2 reduction strategies including energy efficiency improvement.
The center’s work also includes analyzing the impact of potential government or industry-wide policies in the face of uncertainties, some of which are technological and economic as well as political. Besides its research activities, the center has also sponsored seminars and workshops throughout the year to raise awareness of the importance of CO2 management in building a sustainable future.
President Kang said that, from the beginning, the center has prompted researchers and students with different academic backgrounds and skill sets to work together to find integrative and systematic solutions to address real problems of critical importance to the world’s sustainability.
ISCN is a global non-profit association of leading colleges and universities representing over 20 countries, working together to holistically integrate sustainability into campus operations, research, and teaching. As of now, more 75 universities worldwide are the members of ISCN.
The GULF is composed of the presidents of the top 25 universities in the world. The World Economic Forum created it in 2006 to offer a non-competitive platform for high-level dialogue in academia. KAIST is the only Korean GULF member.
For the full report of the 2016 ISCN and GULF conference, go to http://www.international-sustainable-campus-network.org/downloads/general/441-2016-iscn-gulf-best-practice-report/file.
2016.01.25 View 9356 -
'Engineered Bacterium Produces 1,3-Diaminopropane'
A research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST reported, for the first time, the production of 1,3-diaminopropane via fermentation of an engineered bacterium.
1,3-Diaminopropane is a three carbon diamine, which has a wide range of industrial applications including epoxy resin and cross-linking agents, as well as precursors for pharmaceuticals, agrochemicals, and organic chemicals. It can also be polymerized with dicarboxylic acids to make polyamides (nylons) for use as engineering plastics, medical materials, and adhesives.
Traditionally, 1,3-diaminopropane is derived from petroleum-based processes. In effort to address critical problems such as the depletion of petroleum and environmental issues inherent to the petroleum-based processes, the research team has developed an Escherichia coli (E. coli) strain capable of producing 1,3-diaminopropane. Using this technology, 1,3-diaminopropane can now be produced from renewable biomass instead of petroleum.
E. coli as found in nature is unable to produce 1,3-diaminopropane. Metabolic engineering, a technology to transform microorganisms into highly efficient microbial cell factories capable of producing chemical compounds of interest, was utilized to engineer the E. coli strain. First, naturally existing metabolic pathways for the biosynthesis of 1,3-diaminopropane were introduced into a virtual cell in silico to determine the most efficient metabolic pathway for the 1,3-diaminopropane production. The metabolic pathway selected was then introduced into an E. coli strain and successfully produced 1,3-diaminopropane for the first time in the world.
The research team applied metabolic engineering additionally, and the production titer of 1,3-diaminopropane increased about 21 fold. The Fed-batch fermentation of the engineered E. coli strain produced 13 grams per liter of 1,3-diaminoproapne. With this technology, 1,3-diaminopropane can be produced using renewable biomass, and it will be the starting point for replacing the current petroleum-based processes with bio-based processes.
Professor Lee said, “Our study suggested a possibility to produce 1,3-diaminopropane based on biorefinery. Further study will be done to increase the titer and productivity of 1,3-diaminopropane.”
This work was published online in Scientific Reports on August 11, 2015.
Reference: Chae, T.U. et al. "Metabolic engineering of Escherichia coli for the production of 1,3-diaminopropane, a three carbon diamine," Scientific Reports:
http://www.nature.com/articles/srep13040
This research was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea.
Figure 1: Metabolic engineering strategies for 1,3-diaminopropane production using C4 pathway
Figure 2: Fed-batch fermentation profiles of two final engineered E. coli strains
2015.08.12 View 10106 -
KAIST Startups Annually Engage 33,000 People, and Their Sales Total Nearly 10 Billion Dollars
According to a recent study, KAIST startups annually engage 33,000 people, and their sales total nearly 10 billion US dollars. Also amongst 1,245 companies, 50 were listed in stock markets including KOSDAQ and KONEX. President Kang of KAIST commissioned an evaluation of KAIST startups last year. The report consisted of six chapters: current status of entrepreneurs and companies, cross analysis based on individuals’ background and academic degree, annual performance analysis, and current status of startup assistance.
The report categorized the startups with respect to the founders’ background. Of 1,245 companies, KAIST alumni founded 929 (74.6%) of the companies under study: 191 (15.3%) were located within the KAIST campuses, 91 (7.3%) were founded by enrolled students, and 74 (2.7%) by professors. The startup founders had different levels of education: 515 (41.4%) founders had master’s degree, 443 (35.6%) Ph.D. degree, and only 213 (17.1%) had only bachelor’s degree as the highest level of education attained. The reason behind the majority of founders having a master’s degree or higher degree is that many people established a startup after obtaining specialized knowledge and skills.
Focusing on the founders’ college majors, 719 (70.6%) founders were from the engineering department, 111 (10.9%) from the business administration department, 103 (10.1%) from the natural science department, and 86 (8.4%) from other departments. Looking at the companies' locations, 462 (37.5%) were placed in Seoul, 355 (28.8%) in Daejeon, and 273 (22.2%) in Gyeonggi.
By the end of 2013, the total asset of 1,069 companies came to 12 billion and 444 million dollars. Their total sales figure was 10 billion and 13 million dollars, and annual employments summed up to 33,000 people. The companies generated a significant portion of gross regional domestic product (GRDP) in each region. They formed 0.49% of GRDP of Seoul, took up 1.67% GRDP of Gyeonggi, and 5.53% of that of Daejeon.
Along with the performance analysis, the report also took a survey of suggestions on future startup assistance and opinions on current startup assistance policies. To a question asking what constituted the most difficult part of startup, 31.7% of respondents answered “attraction of investment,” 22.8% chose “a lack of human resources,” and 16.8% said “consulting” amongst 214 respondents. The study showed that major and medium enterprises face difficulty in finding human resources whereas small businesses experience obstacles attracting investment. Some startups had help from KAIST: 44 startups were provided with the office space, 21 had educational supports, and 18 were supported in research and development.
The report demonstrates that startups established by KAIST alumni and members play a key role in the South Korean economy despite KAIST’s short startup history, which began only since the end of 1990s. Based on this report, KAIST plans to listen continuously to the needs of alumni founders, and use those responses as a guide to entrepreneurship education for current students.
The Dean of the Office of University and Industry Cooperation, Joongmyeon Bae, who oversaw the publication of this report, said, "As this report is the first in Korea to study the status of alumni startups, it will be incredibly valuable in modifying the startup assistance policies.”
To spread an entrepreneurial spirit and start-up cultures in the campus and enhance the startup supporting system, KAIST has founded various startup centers on and off the campus.
2015.07.14 View 7458