eco-friendly
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Interactive Map of Metabolical Synthesis of Chemicals
An interactive map that compiled the chemicals produced by biological, chemical and combined reactions has been distributed on the web
- A team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering, organized and distributed an all-inclusive listing of chemical substances that can be synthesized using microorganisms
- It is expected to be used by researchers around the world as it enables easy assessment of the synthetic pathway through the web.
A research team comprised of Woo Dae Jang, Gi Bae Kim, and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST reported an interactive metabolic map of bio-based chemicals. Their research paper “An interactive metabolic map of bio-based chemicals” was published online in Trends in Biotechnology on August 10, 2022.
As a response to rapid climate change and environmental pollution, research on the production of petrochemical products using microorganisms is receiving attention as a sustainable alternative to existing methods of productions. In order to synthesize various chemical substances, materials, and fuel using microorganisms, it is necessary to first construct the biosynthetic pathway toward desired product by exploration and discovery and introduce them into microorganisms. In addition, in order to efficiently synthesize various chemical substances, it is sometimes necessary to employ chemical methods along with bioengineering methods using microorganisms at the same time. For the production of non-native chemicals, novel pathways are designed by recruiting enzymes from heterologous sources or employing enzymes designed though rational engineering, directed evolution, or ab initio design.
The research team had completed a map of chemicals which compiled all available pathways of biological and/or chemical reactions that lead to the production of various bio-based chemicals back in 2019 and published the map in Nature Catalysis. The map was distributed in the form of a poster to industries and academia so that the synthesis paths of bio-based chemicals could be checked at a glance.
The research team has expanded the bio-based chemicals map this time in the form of an interactive map on the web so that anyone with internet access can quickly explore efficient paths to synthesize desired products. The web-based map provides interactive visual tools to allow interactive visualization, exploration, and analysis of complex networks of biological and/or chemical reactions toward the desired products. In addition, the reported paper also discusses the production of natural compounds that are used for diverse purposes such as food and medicine, which will help designing novel pathways through similar approaches or by exploiting the promiscuity of enzymes described in the map. The published bio-based chemicals map is also available at http://systemsbiotech.co.kr.
The co-first authors, Dr. Woo Dae Jang and Ph.D. student Gi Bae Kim, said, “We conducted this study to address the demand for updating the previously distributed chemicals map and enhancing its versatility.” “The map is expected to be utilized in a variety of research and in efforts to set strategies and prospects for chemical production incorporating bio and chemical methods that are detailed in the map.”
Distinguished Professor Sang Yup Lee said, “The interactive bio-based chemicals map is expected to help design and optimization of the metabolic pathways for the biosynthesis of target chemicals together with the strategies of chemical conversions, serving as a blueprint for developing further ideas on the production of desired chemicals through biological and/or chemical reactions.”
The interactive metabolic map of bio-based chemicals.
2022.08.11 View 3609 -
Bae's Design Team Wins Good Design Award
An eco-friendly pot humidifier designed by a KAIST team led by Prof. Sang-Min Bae of the Department of Industrial Design won the G-Mark award at the 2009 Good Design Award, university authorities said on Tuesday (Sept. 29).
The Good Design Award is a Japanese comprehensive design evaluation and commendation system operated by the Japan Industrial Design Promotion Organization (JIDPO). It originated from the Good Design Selection system, known as the "G-Mark System," instituted by the Ministry of International Trade and Industry of Japan in 1957. More than 1,000 companies and designers from 50-odd countries submit about 3,000 entries for consideration for the Good Design Awards each year.
The humidifier controls the indoor humidity by natural vaporization using the tissue ball. The tissue ball is made of honeycomb shaped felt so that it can enhance water absorbing ability with large surface. In the package of the pot, there is a bottle of aroma liquid and people can use it for the fragrances as well as humidification.
The pot, called "Love Pot," was designed for the Nanum (Sharing) Project, a charity activity to establish funds for donations through new products development. International aid organization World Vision, oil company GS Caltex and Prof. Bae"s ID+IM design laboratory have teamed up for the project.
The KAIST team worked for free to design the pot. Profits from the sale of the pots were donated for education programs for low-income households. Among the products made under the Nanum Project was a cross cube MP3 player which won the silver prize at the 2008 International Design Excellence Awards (IDEA). IDEA is one of the world"s top three design awards along with Germany"s International Forum DEsign Awards and the Red Dot Design Awards.
Prof. Bae"s team also won the "Best of the Best" award at Red Dot last November with the "Roly Poly Pot," a planter that tips to the side when the plant is thirsty.
2009.10.01 View 9236 -
Prof. Park to Receive HP's Annual Innovation Research Award
Prof. In-Kyu Park of the Department of Mechanical Engineering, KAIST, has been will receive an award from Hewlett-Packard"s second annual Labs Innovation Research Program, university authorities said on Wednesday (July 8).
Prof. Park was chosen as the winner of the research award for his paper entitled "Eco-friendly nanomanufacturing for intelligent environment sensing applications."
Sixty projects from 46 universities in 12 countries were selected as the recipients of the awards from HP Labs, the company"s central research arm. The program is designed to create opportunities for colleges, universities and research institutes to conduct collaborative research with HP.
HP Labs Innovation Research Awards provide project funding of up to $100,000 for one year to each of the chosen academic institutions, which is renewable for up to three years based on research progress and HP business requirements.
Prof. Park has conducted joint researches on nanoimprinting, nanosensors, and nanoelectronics with HP"s Information and Quantum Systems Lab since 2005. Starting from the later half of 2009, he is to receive research grants under the industry-academia cooperation program of the world"s information technology giant firm.
2009.07.09 View 9621