eco-friendly
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KAIST Develops Eco-Friendly, Nylon-Like Plastic Using Microorganisms
Poly(ester amide) amide is a next-generation material that combines the advantages of PET (polyester) and nylon (polyamide), two widely used plastics. However, it could only be produced from fossil fuels, which posed environmental concerns. Using microorganisms, KAIST researchers have successfully developed a new bio-based plastic to replace conventional plastic.
KAIST (represented by President Kwang Hyung Lee) announced on the 20th of March that a research team led by Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering has developed microbial strains through systems metabolic engineering to produce various eco-friendly, bio-based poly(ester amide)s. The team collaborated with researchers from the Korea Research Institute of Chemical Technology (KRICT, President Young-Kook Lee) to analyze and confirm the properties of the resulting plastic.
Professor Sang Yup Lee’s research team designed new metabolic pathways that do not naturally exist in microorganisms, and developed a platform microbial strain capable of producing nine different types of poly(ester amide)s, including poly(3-hydroxybutyrate-ran-3-aminopropionate) and poly(3-hydroxybutyrate-ran-4-aminobutyrate).
Using glucose derived from abundant biomass sources such as waste wood and weeds, the team successfully produced poly(ester amide)s in an eco-friendly manner. The researchers also confirmed the potential for industrial-scale production by demonstrating high production efficiency (54.57 g/L) using fed-batch fermentation of the engineered strain.
In collaboration with researchers Haemin Jeong and Jihoon Shin from KRICT, the KAIST team analyzed the properties of the bio-based plastic and found that it exhibited characteristics similar to high-density polyethylene (HDPE). This means the new plastic is not only eco-friendly but also strong and durable enough to replace conventional plastics.
The engineered strains and strategies developed in this study are expected to be useful not only for producing various poly(ester amide)s but also for constructing metabolic pathways for the biosynthesis of other types of polymers.
Professor Sang Yup Lee stated, “This study is the first to demonstrate the possibility of producing poly(ester amide)s (plastics) through a renewable bio-based chemical process rather than relying on the petroleum-based chemical industry. We plan to further enhance the production yield and efficiency through continued research.”
The study was published online on March 17 in the international journal Nature Chemical Biology.
·Title: Biosynthesis of poly(ester amide)s in engineered Escherichia coli
·DOI: 10.1038/s41589-025-01842-2
·Authors: A total of seven authors including Tong Un Chae (KAIST, first author), So Young Choi (KAIST, second author), Da-Hee Ahn (KAIST, third author), Woo Dae Jang (KAIST, fourth author), Haemin Jeong (KRICT, fifth author), Jihoon Shin (KRICT, sixth author), and Sang Yup Lee (KAIST, corresponding author).
This research was supported by the Ministry of Science and ICT (MSIT) under the Eco-Friendly Chemical Technology Development Project as part of the "Next-Generation Biorefinery Technology Development to Lead the Bio-Chemical Industry" initiative (project led by Distinguished Professor Sang Yup Lee at KAIST).
2025.03.24 View 2346 -
KAIST Develops World-Leading Ammonia Catalyst for Hydrogen Economy
Hydrogen production using renewable energy is a key technology for eco-friendly energy and chemical production. However, storing and transporting hydrogen remains a challenge. To address this, researchers worldwide are investigating methods to store hydrogen in the form of ammonia (NH₃), which is carbon-free and easier to liquify. A research team at KAIST has successfully developed a high-performance catalyst that enables ammonia synthesis at very low temperatures and pressures without energy loss.
KAIST (represented by President Kwang Hyung Lee) announced on the 11th of March that a research team led by Professor Minkee Choi from the Department of Chemical and Biomolecular Engineering has developed an innovative catalytic system that significantly enhances ammonia production while drastically reducing energy consumption and CO₂ emissions.
< (From left) Baek Ye-jun, Ph.D. candidate in the Department of Biochemical Engineering, Professor Choi Min-ki >
Currently, ammonia is produced using the Haber-Bosch process, a technology over a century old that relies on iron (Fe)-based catalysts. This method requires extreme conditions—temperatures above 500°C and pressures exceeding 100 atmospheres—resulting in enormous energy consumption and contributing significantly to global CO₂ emissions. Additionally, ammonia is primarily produced in large-scale industrial plants, leading to high distribution costs.
As an alternative, there is growing interest in an eco-friendly process that synthesizes ammonia using green hydrogen—produced via water electrolysis—under mild conditions (300°C, 10 atmospheres). However, developing catalysts that can achieve high ammonia productivity at such low temperatures and pressures is essential, as current technologies struggle to maintain efficiency under these conditions.
The research team developed a novel catalyst by incorporating ruthenium (Ru) nanoparticles and highly basic barium oxide (BaO) particles onto a conductive carbon surface, allowing it to function like a chemical capacitor*.
*Capacitor: A device that stores electrical energy by separating positive and negative charges.
During ammonia synthesis, hydrogen molecules (H₂) first dissociate into hydrogen atoms (H) on the ruthenium catalyst. These hydrogen atoms are further split into protons (H⁺) and electrons (e⁻). The study revealed that the acidic protons are stored in the strongly basic BaO, while the remaining electrons are separated and stored in ruthenium and carbon.
This unique chemical capacitor effect significantly enhances the ruthenium catalyst's electron density, accelerating nitrogen (N₂) dissociation—the rate-limiting step of ammonia synthesis—thereby dramatically increasing catalytic activity.
Furthermore, the team discovered that optimizing the nanostructure of the carbon material further boosts the electron density of ruthenium, maximizing catalytic performance. As a result, the new catalyst demonstrated over seven times higher ammonia synthesis performance compared to state-of-the-art catalysts under mild conditions (300°C, 10 atm).
< Schematic diagram showing the mechanism of ruthenium catalyst activity enhancement by barium oxide cocatalyst >
Professor Minkee Choi stated, “This research has garnered significant attention for demonstrating that catalytic activity can be greatly enhanced by controlling electron transfer within a thermal catalytic reaction system, not just in electrochemical processes.”
He further explained, “Our findings confirm that high-performance catalysts can enable efficient ammonia synthesis under low-temperature and low-pressure conditions. This could shift ammonia production from centralized, large-scale industrial plants to decentralized, small-scale production, making the hydrogen economy more sustainable and flexible.”
The study was led by Professor Minkee Choi as corresponding author and Yaejun Baik, a Ph.D. candidate, as first author. The research findings were published in Nature Catalysis on February 24.
(Paper title: “Electron and proton storage on separate Ru and BaO domains mediated by conductive low-work-function carbon to accelerate ammonia synthesis,” https://doi.org/10.1038/s41929-025-01302-z)
This research was supported by the Korea Institute of Energy Research and the National Research Foundation of Korea.
2025.03.11 View 1393 -
Novel High-performance and Sustainable Paper Coating Material created by KAIST-Yonsei University Research Team to reduce microplastic pollution
What if there is a biodegradable packaging material with high performance without leaving microplastics?
Plastic pollution presents a global challenge that must be solved. In particular, packaging accounts for 30-50% of the total plastic consumption. While paper packaging is eco-friendly, it lacks crucial functionalities like moisture resistance and strength. Traditional coating materials exacerbate plastic pollution, prompting the need for sustainable alternatives.
Polyethylene (PE) and ethylene vinyl alcohol (EVOH) are typically used as coating materials to improve the low barrier properties of paper packaging, but these substances do not decompose and worsen microplastic pollution when disposed of in the natural environment. In response to this problem, packaging materials made from bio-based substances and biodegradable plastics have been developed, but in most cases, as the packaging performance improves, the biodegradability diminishes rapidly.
KAIST announced that a joint research team led by Professor Jaewook Myung of the Department of Civil and Environmental Engineering, Professor Hanseul Yang of the Department of Life Sciences, and Professor Jongcheol Seo of the Department of Packaging and Logistics <Figure 4. Back cover art of Green Chemistry journal of the latest volume, describing the boric acid cross-linked poly(vinyl alcohol) coated paper featuring marine biodegradability, biocompatibility, high barrier properties, and robustness developed through this study.>
at Yonsei University tackled the challenge of balancing packaging performance and sustainability. They successfully developed a sustainable, marine biodegradable, high-performance paper coating material.
* Biodegradable plastic: A plastic that can be decomposed by microorganisms in natural environments such as soil and ocean or artificial conditions such as industrial composting and anaerobic digestion by microorganisms.
*Microplastics: Tiny pieces of plastic less than 5 mm, produced during the decomposition of bulk plastic materials. Microplastics can persist in the sea for more than decades, causing severe marine pollution.
The team utilized boric acid-crosslinked poly(vinyl alcohol) (PVA), a biodegradable plastic, to coat the paper, thereby enhancing its biodegradability, barrier properties, and strength. The resulting coated paper exhibited superior performance compared to conventional plastics, with excellent barrier properties and physical strength, even in humid conditions.
<Figure 1. (a) Chemical structure of boric acid-crosslinked poly(vinyl alcohol) coating on paper, (b-c) Oxygen and water vapor barrier properties, (d-f) Tensile strength in dry and moist conditions. OTR: Oxygen transmission rate, WVTR: Water vapor transmission rate.>
The team also conducted an in-depth examination of biodegradation and biocompatibility to systematically evaluate the sustainability of the newly developed coated paper. Biodegradation was assessed by simulating the marine environment, known for its challenging biodegradability conditions. The team employed a respiratory system-based bioreactor to measure the degree of carbon mineralization into carbon dioxide. After 111 days of biodegradation, it was found that the coated papers achieved 59-82% biodegradation depending on the coating component. The phenomenon in which marine bacteria are decomposing the coating material was captured through a scanning electron microscope. In addition, in vitro biocompatibility was confirmed through human embryonic kidney and mouse embryonic fibroblast cells, as well as high in-vivo biocompatibility of the coated paper was verified through mouse experiments.
Through this study, the joint research team proposed a coating strategy that can improve packaging performance while upholding sustainability to address the drawbacks of paper packaging. The boric acid-crosslinked PVA-coated paper eliminates the need for artificial composting conditions or sewage treatment facilities. Being biodegradable in natural environments and characterized by low toxicity, this newly coated paper does not exacerbate environmental pollution when accidentally discarded. Thus, it presents a sustainable substitute for plastic packaging materials.
<Figure 2. (a) Normal paper and boric acid-crosslinked poly(vinyl alcohol) coated paper, (b) Biodegradation of the coated paper by marine bacteria, (c) Result of cytotoxicity test using human embryonic kidney and mouse embryonic fibroblast cells. (d) Vital organs after one-month exposure of the coated papers to mice.>
Professor Jaewook Myung at KAIST, who led the sustainability study of coated paper, said, "The development of a marine biodegradable high-performance paper coating is the result of combining the innovative technologies of three leading research teams in each field." He said, “We will continue to develop sustainable materials with excellent performance.” Meanwhile, Professor Jongchul Seo of Yonsei University, who led the research on the development of high-performance paper coating, mentioned, “Through this research, we have developed a sustainable paper packaging technology that can replace non-degradable plastic packaging, and we expect the research outcome will be applied in industry,”.
<Figure 3. End-of-life scenario of papers coated by BA-crosslinked PVA in the marine environment. The coated papers potentially be disintegrated by marine microorganisms and ocean waves and tides. The depolymerization of PVA coating and paper is then mediated by extracellular depolymerases such as oxidases and cellulases, after which the small subunits (oligomers and monomers) are assimilated by microbial cells. The carbon components in the coated papers are ultimately mineralized into CO2, posing no harm in the ocean.>
The work was published in Green Chemistry and Food Chemistry journals. This study was conducted with the support of the Korea Research Foundation and the Korea Institute for Agriculture, Food and Rural Affairs Technology Planning and Evaluation, etc.
*Title of paper published in Green Chemistry: Boric acid-crosslinked poly(vinyl alcohol): biodegradable, biocompatible, robust, and high-barrier paper coating
※ Selected as the article for the back cover of the journal .
- Authors: Shinhyeong Choe, Seulki You, Kitae Park, Youngju Kim, Jehee Park, Yongjun Cho, Jongchul Seo, Hanseul Yang, and Jaewook Myung)
- Date: April 17, 2024
- DOI: 10.1039/D4GC00618F
*Title of paper published in Food Chemistry: Effect of epichlorohydrin treatment on the coating process and performance of high-barrier paper packaging
- Authors: Kitae Park, Shinhyeong Choe, Kambiz Sadeghi, Pradeep Kumar Panda, Jaewook Myung, Dowan Kim, and Jongchul Seo
- Date: February 19, 2024
- DOI: 10.1016/j.foodchem.2024.138772
<Figure 4. Back cover art of Green Chemistry journal of the latest volume, describing the boric acid cross-linked poly(vinyl alcohol) coated paper featuring marine biodegradability, biocompatibility, high barrier properties, and robustness developed through this study.>
2024.05.22 View 6497 -
KAIST introduces microbial food as a strategy food production of the future
The global food crisis is increasing due to rapid population growth and declining food productivity to climate change. Moreover, today's food production and supply system emit a huge amount of carbon dioxide, reaching 30% of the total amount emitted by humanity, aggravating climate change. Sustainable and nutritious microbial food is attracting attention as a key to overcoming this impasse.
KAIST (President Kwang Hyung Lee) announced on April 12th that Research Professor Kyeong Rok Choi of the BioProcess Engineering Research Center and Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering published a paper that proposes a direction of research on ‘microbial food production from sustainable raw materials.’
Microbial food refers to various foods and food ingredients produced using microorganisms. Microbial biomass contains a large amount of protein per unit in dry mass, comparable to that of meat, and emits the smallest amount of carbon dioxide and is required to produce a unit mass compared to various livestock, fish, shellfish, and crops. Since the amount of water and space requirement is small, it can be an eco-friendly, sustainable and highly nutritious food resource.
Fermented foods are the most readily available microbial foods around us. Although the proportion of microbial biomass in fermented foods is small, compounds with relatively low nutritional value, such as carbohydrates, are consumed during the fermentation process, and as microorganisms proliferate, the content of nutrients with higher nutritional value, such as proteins and vitamins, increases.
Various food compounds isolated and purified from biomass or culture media obtained through microbial culture are also a branch of microbial food. Examples that can be found around us include various amino acids, including monosodium glutamate, food proteins, enzymes, flavoring compounds, food colorings, and bioactive substances.
< Figure 1. Schematic diagram portraying various microbial biomass production strategies utlizing sustainable feedstocks >
Lastly, the most ultimate and fundamental form of microbial food can be said to be microbial biomass or extracts produced through microbial culture and foods cooked using them. A representative example is single-cell protein, which collectively refers to microbial biomass or microbial proteins extracted from it.
In this paper, the researchers comprehensively covered various non-edible raw materials and strategies for using them that can be used to produce microbial food in a more sustainable way. Furthermore, it covers various microbial foods that are actually produced in the industry using the relevant raw materials and their characteristics, as well as prospects for the production and generalization of sustainable microbial foods.
Research Professor Kyeong Rok Choi, the first author of this paper, said, “Microbial foods produced from various sustainable raw materials will soon be commonly encountered at our tables.” Second author Seok Yeong Jung, a doctoral student, also said, “Microbial foods of the future will not be limited foods consumed only out of a sense of obligation to the environment, but will be complete foods that are consumed by choice because of their nutritional value and taste.” In addition, Distinguished Professor Sang Yup Lee said, “It is time for the industry and academia, as well as the public and private sectors, to cooperate more closely so that more diverse microbial foods can be developed and supplied in order to create a sustainable society for ourselves and our descendants.”
< Figure 2. Compositions and environmental footprints of animal, plant and microbial biomass. >
This paper was published online on April 9 in ‘Nature Microbiology’ published by Nature.
※ Paper title: From sustainable feedstocks to microbial foods
※ Author information: Kyeong Rok Choi (first author), Seok Yeong Jung (second author) and Sang Yup Lee (corresponding author)
This research was conducted under the development of platform technologies of microbial cell factories for the next-generation biorefineries project (project leader KAIST Distinguished Professor Sang Yup Lee) supported by the Ministry of Science and ICT and the Cooperative Research Program for Agriculture Science and Technology Development (Project leader KAIST Research Professor Kyeong Rok Choi) of the Agricultural Microbiology Project Group (Director, Professor Pahn-Shick Chang) supported by the Rural Development Administration.
2024.04.12 View 6203 -
KAIST introduces eco-friendly technologies for plastic production and biodegradation
- A research team under Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering published a paper in Nature Microbiology on the overview and trends of plastic production and degradation technology using microorganisms.
- Eco-friendly and sustainable plastic production and degradation technology using microorganisms as a core technology to achieve a plastic circular economy was presented.
Plastic is one of the important materials in modern society, with approximately 460 million tons produced annually and with expected production reaching approximately 1.23 billion tons in 2060. However, since 1950, plastic waste totaling more than 6.3 billion tons has been generated, and it is believed that more than 140 million tons of plastic waste has accumulated in the aquatic environment. Recently, the seriousness of microplastic pollution has emerged, not only posing a risk to the marine ecosystem and human health, but also worsening global warming by inhibiting the activity of marine plankton, which play an important role in lowering the Earth's carbon dioxide concentration.
KAIST President Kwang-Hyung Lee announced on December 11 that a research team under Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering had published a paper titled 'Sustainable production and degradation of plastics using microbes', which covers the latest technologies for producing plastics and processing waste plastics in an eco-friendly manner using microorganisms.
As the international community moves to solve this plastic problem, various efforts are being made, including 175 countries participating to conclude a legally binding agreement with the goal of ending plastic pollution by 2024. Various technologies are being developed for sustainable plastic production and processing, and among them, biotechnology using microorganisms is attracting attention.
Microorganisms have the ability to naturally produce or decompose certain compounds, and this ability is maximized through biotechnologies such as metabolic engineering and enzyme engineering to produce plastics from renewable biomass resources instead of fossil raw materials and to decompose waste plastics.
Accordingly, the research team comprehensively analyzed the latest microorganism-based technologies for the sustainable production and decomposition of plastics and presented how they actually contribute to solving the plastic problem. Based on this, they presented limitations, prospects, and research directions of the technologies for achieving a circular economy for plastics.
Microorganism-based technologies for various plastics range from widely used synthetic plastics such as polyethylene (PE) to promising bioplastics such as natural polymers derived from microorganisms (polyhydroxyalkanoate (PHA)) that are completely biodegradable in the natural environment and do not pose a risk of microplastic generation. Commercialization statuses and latest technologies were also discussed. In addition, the technology to decompose these plastics using microorganisms and their enzymes and the upcycling technology to convert them into other useful compounds after decomposition were introduced, highlighting the competitiveness and potential of technology using microorganisms.
First author So Young Choi, a research assistant professor in the Department of Chemical and Biomolecular Engineering at KAIST, said, “In the future, we will be able to easily find eco-friendly plastics made using microorganisms all around us,” and corresponding author Distinguished Professor Sang Yup Lee said, “Plastic can be made more sustainable. It is important to use plastics responsibly to protect the environment and simultaneously achieve economic and social development through the new plastics industry, and we look forward to the improved performance of microbial metabolic engineering technology.”
This paper was published on November 30th in the online edition of Nature Microbiology.
※ Paper Title : Sustainable production and degradation of plastics using microbes
Authors: So Young Choi, Youngjoon Lee, Hye Eun Yu, In Jin Cho, Minju Kang & Sang Yup Lee
2023.12.11 View 6001 -
KAIST presents a microbial cell factory as a source of eco-friendly food and cosmetic coloring
Despite decades of global population growth, global food crisis seems to be at hand yet again because the food productivity is cut severely due to prolonged presence of abnormal weather from intensifying climate change and global food supply chain is deteriorated due to international conflicts such as wars exacerbating food shortages and nutritional inequality around the globe. At the same time, however, as awareness of the environment and sustainability rises, an increase in demand for more eco-friendly and high-quality food and beauty products is being observed not without a sense of irony. At a time like this, microorganisms are attracting attention as a key that can handle this couple of seemingly distant problems.
KAIST (President Kwang-Hyung Lee) announced on the 26th that Kyeong Rok Choi, a research professor of the Bioprocess Research Center and Sang Yup Lee, a Distinguished Professor of the Department of Chemical and Biomolecular Engineering, published a paper titled “Metabolic Engineering of Microorganisms for Food and Cosmetics Production” upon invitation by “Nature Reviews Bioengineering” to be published online published by Nature after peer review.
※ Paper title: Systems metabolic engineering of microorganisms for food and cosmetics production
※ Author information: Kyeong Rok Choi (first author) and Sang Yup Lee (corresponding author)
Systems metabolic engineering is a research field founded by Distinguished Professor Sang Yup Lee of KAIST to more effectively develop microbial cell factories, the core factor of the next-generation bio industry to replace the existing chemical industry that relies heavily on petroleum. By applying a systemic metabolic engineering strategy, the researchers have developed a number of high-performance microbial cell factories that produce a variety of food and cosmetic compounds including natural substances like heme and zinc protoporphyrin IX compounds which can improve the flavor and color of synthetic meat, lycopene and β-carotene which are functional natural pigments that can be widely used in food and cosmetics, and methyl anthranilate, a grape-derived compound widely used to impart grape flavor in food and beverage manufacturing.
In this paper written upon invitation by Nature, the research team covered remarkable cases of microbial cell factory that can produce amino acids, proteins, fats and fatty acids, vitamins, flavors, pigments, alcohols, functional compounds and other food additives used in various foods and cosmetics and the companies that have successfully commercialized these microbial-derived materials Furthermore, the paper organized and presents systems metabolic engineering strategies that can spur the development of industrial microbial cell factories that can produce more diverse food and cosmetic compounds in an eco-friendly way with economic feasibility.
< Figure 1. Examples of production of food and cosmetic compounds using microbial cell factories >
For example, by producing proteins or amino acids with high nutritional value through non-edible biomass used as animal feed or fertilizer through the microbial fermentation process, it will contribute to the increase in production and stable supply of food around the world. Furthermore, by contributing to developing more viable alternative meat, further reducing dependence on animal protein, it can also contribute to reducing greenhouse gases and environmental pollution generated through livestock breeding or fish farming.
In addition, vanillin or methyl anthranilate, which give off vanilla or grape flavor, are widely added to various foods, but natural products isolated and refined from plants are low in production and high in production cost, so in most cases, petrochemicals substances derived from vanillin and methylanthranilic acid are added to food. These materials can also be produced through an eco-friendly and human-friendly method by borrowing the power of microorganisms.
Ethical and resource problems that arise in producing compounds like Calmin (cochineal pigment), a coloring added to various cosmetics and foods such as red lipstick and strawberry-flavored milk, which must be extracted from cochineal insects that live only in certain cacti. and Hyaluronic acid, which is widely consumed as a health supplement, but is only present in omega-3 fatty acids extracted from shark or fish livers, can also be resolved when they can be produced in an eco-friendly way using microorganisms.
KAIST Research Professor Kyeong Rok Choi, the first author of this paper, said, “In addition to traditional fermented foods such as kimchi and yogurt, foods produced with the help of microorganisms like cocoa butter, a base ingredient for chocolate that can only be obtained from fermented cacao beans, and monosodium glutamate, a seasoning produced through microbial fermentation are already familiar to us”. “In the future, we will be able to acquire a wider variety of foods and cosmetics even more easily produced in an eco-friendly and sustainable way in our daily lives through microbial cell factories.” he added.
< Figure 2. Systems metabolic engineering strategy to improve metabolic flow in microbial cell factories >
Distinguished Professor Sang Yup Lee said, “It is engineers’ mission to make the world a better place utilizing science and technology.” and added, “Continuous advancement and active use of systems metabolic engineering will contribute greatly to easing and resolving the problems arising from both the food crisis and the climate change."
This research was carried out as a part of the “Development of Protein Production Technology from Inorganic Substances through Control of Microbial Metabolism System Project” (Project Leader: Kyeong Rok Choi, KAIST Research Professor) of the the Center for Agricultural Microorganism and Enzyme (Director Pahn-Shick Chang) supported by the Rural Development Administration and the “Development of Platform Technologies of Microbial Cell Factories for the Next-generation Biorefineries Project” (Project Leader: Sang Yup Lee, KAIST Distinguished Professor) of the Petroleum-Substitute Eco-friendly Chemical Technology Development Program supported by the Ministry of Science and ICT.
2023.07.28 View 7837 -
Interactive Map of Metabolical Synthesis of Chemicals
An interactive map that compiled the chemicals produced by biological, chemical and combined reactions has been distributed on the web
- A team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering, organized and distributed an all-inclusive listing of chemical substances that can be synthesized using microorganisms
- It is expected to be used by researchers around the world as it enables easy assessment of the synthetic pathway through the web.
A research team comprised of Woo Dae Jang, Gi Bae Kim, and Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST reported an interactive metabolic map of bio-based chemicals. Their research paper “An interactive metabolic map of bio-based chemicals” was published online in Trends in Biotechnology on August 10, 2022.
As a response to rapid climate change and environmental pollution, research on the production of petrochemical products using microorganisms is receiving attention as a sustainable alternative to existing methods of productions. In order to synthesize various chemical substances, materials, and fuel using microorganisms, it is necessary to first construct the biosynthetic pathway toward desired product by exploration and discovery and introduce them into microorganisms. In addition, in order to efficiently synthesize various chemical substances, it is sometimes necessary to employ chemical methods along with bioengineering methods using microorganisms at the same time. For the production of non-native chemicals, novel pathways are designed by recruiting enzymes from heterologous sources or employing enzymes designed though rational engineering, directed evolution, or ab initio design.
The research team had completed a map of chemicals which compiled all available pathways of biological and/or chemical reactions that lead to the production of various bio-based chemicals back in 2019 and published the map in Nature Catalysis. The map was distributed in the form of a poster to industries and academia so that the synthesis paths of bio-based chemicals could be checked at a glance.
The research team has expanded the bio-based chemicals map this time in the form of an interactive map on the web so that anyone with internet access can quickly explore efficient paths to synthesize desired products. The web-based map provides interactive visual tools to allow interactive visualization, exploration, and analysis of complex networks of biological and/or chemical reactions toward the desired products. In addition, the reported paper also discusses the production of natural compounds that are used for diverse purposes such as food and medicine, which will help designing novel pathways through similar approaches or by exploiting the promiscuity of enzymes described in the map. The published bio-based chemicals map is also available at http://systemsbiotech.co.kr.
The co-first authors, Dr. Woo Dae Jang and Ph.D. student Gi Bae Kim, said, “We conducted this study to address the demand for updating the previously distributed chemicals map and enhancing its versatility.” “The map is expected to be utilized in a variety of research and in efforts to set strategies and prospects for chemical production incorporating bio and chemical methods that are detailed in the map.”
Distinguished Professor Sang Yup Lee said, “The interactive bio-based chemicals map is expected to help design and optimization of the metabolic pathways for the biosynthesis of target chemicals together with the strategies of chemical conversions, serving as a blueprint for developing further ideas on the production of desired chemicals through biological and/or chemical reactions.”
The interactive metabolic map of bio-based chemicals.
2022.08.11 View 13727 -
Bae's Design Team Wins Good Design Award
An eco-friendly pot humidifier designed by a KAIST team led by Prof. Sang-Min Bae of the Department of Industrial Design won the G-Mark award at the 2009 Good Design Award, university authorities said on Tuesday (Sept. 29).
The Good Design Award is a Japanese comprehensive design evaluation and commendation system operated by the Japan Industrial Design Promotion Organization (JIDPO). It originated from the Good Design Selection system, known as the "G-Mark System," instituted by the Ministry of International Trade and Industry of Japan in 1957. More than 1,000 companies and designers from 50-odd countries submit about 3,000 entries for consideration for the Good Design Awards each year.
The humidifier controls the indoor humidity by natural vaporization using the tissue ball. The tissue ball is made of honeycomb shaped felt so that it can enhance water absorbing ability with large surface. In the package of the pot, there is a bottle of aroma liquid and people can use it for the fragrances as well as humidification.
The pot, called "Love Pot," was designed for the Nanum (Sharing) Project, a charity activity to establish funds for donations through new products development. International aid organization World Vision, oil company GS Caltex and Prof. Bae"s ID+IM design laboratory have teamed up for the project.
The KAIST team worked for free to design the pot. Profits from the sale of the pots were donated for education programs for low-income households. Among the products made under the Nanum Project was a cross cube MP3 player which won the silver prize at the 2008 International Design Excellence Awards (IDEA). IDEA is one of the world"s top three design awards along with Germany"s International Forum DEsign Awards and the Red Dot Design Awards.
Prof. Bae"s team also won the "Best of the Best" award at Red Dot last November with the "Roly Poly Pot," a planter that tips to the side when the plant is thirsty.
2009.10.01 View 13097 -
Prof. Park to Receive HP's Annual Innovation Research Award
Prof. In-Kyu Park of the Department of Mechanical Engineering, KAIST, has been will receive an award from Hewlett-Packard"s second annual Labs Innovation Research Program, university authorities said on Wednesday (July 8).
Prof. Park was chosen as the winner of the research award for his paper entitled "Eco-friendly nanomanufacturing for intelligent environment sensing applications."
Sixty projects from 46 universities in 12 countries were selected as the recipients of the awards from HP Labs, the company"s central research arm. The program is designed to create opportunities for colleges, universities and research institutes to conduct collaborative research with HP.
HP Labs Innovation Research Awards provide project funding of up to $100,000 for one year to each of the chosen academic institutions, which is renewable for up to three years based on research progress and HP business requirements.
Prof. Park has conducted joint researches on nanoimprinting, nanosensors, and nanoelectronics with HP"s Information and Quantum Systems Lab since 2005. Starting from the later half of 2009, he is to receive research grants under the industry-academia cooperation program of the world"s information technology giant firm.
2009.07.09 View 15042