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KAIST, National Quantum Fab Research Institute Opening Ceremony and Research Building Groundbreaking Ceremony Held
<Groundbreaking Ceremony Shovel Scene for the KAIST National Quantum Fab Research Building>
KAIST announced on December 3rd that it held the opening ceremony for the National Quantum Fab Research Institute and the groundbreaking ceremony for the Quantum Fab Research Building at the KAIST main campus in Daejeon, officially commencing the construction of the nation's core infrastructure to enhance South Korea's quantum technology competitiveness.
The event began with a progress report and introduction of the institute by Yong Hoon Cho, Director of the Quantum Fab Research Institute, followed by a groundbreaking ceremony to mark the official start of the Quantum Fab Research Building's construction and an unveiling of the plaque. Approximately 50 officials attended the event, including Jang-woo Lee, Mayor of Daejeon, Kwang Hyung Lee, President of KAIST, and the presidents of the National Nanofab Center and the Korea Research Institute of Standards and Science, representing government, local government, and collaborating organizations.
<Plaque-Unveiling Scene at the Opening of the KAIST National Quantum Fab Research Institute>
Since being selected as the lead institution for the Quantum Fab in a competition held by the Ministry of Science and ICT and the Institute for Information & Communications Technology Planning & Evaluation last year, our university secured a commitment of 20 billion KRW from the Daejeon Metropolitan City for construction costs and completed the institute's establishment and design. The new Quantum Fab Research Building, with a total floor area of 2,498 ㎡, is targeted for completion in 2027.
The new building will house South Korea's largest specialized, open-access cleanroom fab for quantum devices. A total of 45 billion KRW or more will be invested by 2031, including national funds, local government funds, and KAIST's budget. Over 37 units of advanced equipment will be installed in the 1st and 3rd-floor FAB cleanrooms in stages, along with stability facilities such as Class 100-1,000 cleanliness standards, constant temperature/humidity, and emergency power supply.
The KAIST Quantum Fab operates on a fully open-access system allowing researchers to directly carry out processes. It will support processing technologies for various quantum platforms, including photons, point defects, and neutral atoms, and will also enhance user programs such as training and workshops. Phase 1 service began in July of this year, and Phase 2 full-scale operation, based on the newly installed equipment, will start in 2028.
Jang-woo Lee, Mayor of Daejeon, stated, "The KAIST open-access Quantum Fab is a core platform that will lead the industrialization of quantum technology in South Korea," adding, "Especially since the US and South Korea have designated quantum computing as a strategic field in their $350 billion technology cooperation package, Daejeon's role is becoming even more crucial."
Director Yong-Hoon Cho said, "Through a user-centric process support system, we will play a central role in the national quantum research ecosystem," adding, "Based on our research capabilities and support system, we will expand industry-academia-research cooperation and aim to leap forward as a pilot quantum fab."
President Kwang Hyung Lee remarked, "Quantum science and technology is a core strategic area that will determine the future technological hegemony," and "We will take this opening and groundbreaking ceremony as an opportunity for industry, academia, research, and government to join forces and strengthen the competitiveness of the national quantum ecosystem."
KAIST plans to focus on establishing a self-sustainable virtuous cycle system centered around the Quantum Fab, and will further dedicate efforts to enhancing national strategic technology competitiveness through the nurturing of specialized talent and the development of processing technologies for each platform.
<Bird’s Eye View of the KAIST National Quantum Fab Research Building>
2025.12.04 View 1375 -
3D Worlds from Just a Few Phone Photos
<(From Left) Ph.D candidate Jumin Lee, Ph.D candidate Woo Jae Kim, Ph.D candidate Youngju Na, Ph.D candidate Kyu Beom Han, Professor Sung-eui Yoon>
Existing 3D scene reconstructions require a cumbersome process of precisely measuring physical spaces with LiDAR or 3D scanners, or correcting thousands of photos along with camera pose information. The research team at KAIST has overcome these limitations and introduced a technology enabling the reconstruction of 3D —from tabletop objects to outdoor scenes—with just two to three ordinary photographs. The breakthrough suggests a new paradigm in which spaces captured by camera can be immediately transformed into virtual environments.
KAIST announced on November 6 that the research team led by Professor Sung-Eui Yoon from the School of Computing has developed a new technology called SHARE (Shape-Ray Estimation), which can reconstruct high-quality 3D scenes using only ordinary images, without precise camera pose information.
Existing 3D reconstruction technology has been limited by the requirement of precise camera position and orientation information at the time of shooting to reproduce 3D scenes from a small number of images. This has necessitated specialized equipment or complex calibration processes, making real-world applications difficult and slowing widespread adoption.
To solve these problems, the research team developed a technology that constructs accurate 3D models by simultaneously estimating the 3D scene and the camera orientation using just two to three standard photographs. The technology has been recognized for its high efficiency and versatility, enabling rapid and precise reconstruction in real-world environments without additional training or complex calibration processes.
While existing methods calculate 3D structures from known camera poses, SHARE autonomously extracts spatial information from images themselves and infers both camera pose and scene structure. This enables stable 3D reconstruction without shape distortion by aligning multiple images taken from different positions into a single unified space.
<Representative Image of SHARE Technology>
"The SHARE technology is a breakthrough that dramatically lowers the barrier to entry for 3D reconstruction,” said Professor Sung-Eui Yoon. “It will enable the creation of high-quality content in various industries such as construction, media, and gaming using only a smartphone camera. It also has diverse application possibilities, such as building low-cost simulation environments in the fields of robotics and autonomous driving."
<SHARE Technology, Precise Camera Information and 3D Scene Prediction Technology>
Ph.D. Candidate Youngju Na and M.S candidate Taeyeon Kim participated as co-first authors on the research. The results were presented on September 17th at the IEEE International Conference on Image Processing (ICIP 2025), where the paper received the Best Student Paper Award.
The award, given to only one paper among 643 accepted papers this year—a selection rate of 0.16 percent—once again underscores the excellent research capabilities of the KAIST research team.
Paper Title: Pose-free 3D Gaussian Splatting via Shape-Ray Estimation, DOI: https://arxiv.org/abs/2505.22978
Award Information: https://www.linkedin.com/posts/ieeeicip_congratulations-to-the-icip-2025-best-activity-7374146976449335297-6hXz
This achievement was carried out with support from the Ministry of Science and ICT's SW Star Lab Project under the task 'Development of Perception, Action, and Interaction Algorithms for Unspecified Environments for Open World Robot Services.'
2025.11.10 View 1437 -
Robot-Operated Space Station Construction Goal... 'In-space Servicing and Manufacturing Research Center' Launched
<Plaque Handover Ceremony. (From left) Jae-Hung Han, Director of the Space Research Institute, Ju-won Kang, Head of Engineering Group at the National Research Foundation of Korea Basic Research Headquarters>
KAIST's Space Research Institute announced on the 24th of October that it officially launched the 'Innovative Research Center for the Development of Core Technologies in In-space Servicing and Manufacturing (ISMRC)' at the KAIST Academic Cultural Center on Friday, October 24. About 150 officials from major organizations, including the Korea Aerospace Administration, the National Research Foundation of Korea, and Daejeon Metropolitan City, as well as domestic and foreign space experts, attended the opening ceremony to discuss future cooperation measures. The 'KAIST In-space Servicing and Manufacturing Research Center (ISMRC)' is a large-scale research hub selected for the Ministry of Science and ICT's 2025 Basic Research Project, with a total of 71.2 billion KRW long-term project planned over the next 10 years, including 50 billion KRW in national funding. Daejeon City will also provide a total of 3.6 billion KRW, with 400 million KRW annually starting from 2026. The research goals are to secure core technologies for next-generation space exploration, including: ▲ Construction of Unmanned Space Stations, ▲ Robotics-based In-space Manufacturing, and ▲ Resource Recovery Technology. A team of 14 KAIST professors, led by Director Jae-Hung Han, will spearhead the research, with major domestic and foreign space companies and research institutions participating in joint research. As the 'New Space' era fully commences globally, the In-space Servicing and Manufacturing industry is projected to grow to tens of trillions of Korean won by 2030, driven by the reduction of launch costs and the expansion of private sector participation. This field is evaluated as a core area that will fundamentally change the way humanity engages in space activities, including extending satellite lifespan, on-orbit maintenance and operation, and securing and manufacturing resources in space. Meanwhile, an international symposium was held for two days on October 23-24 at the KAIST Academic Cultural Center and KI Building, coinciding with the opening ceremony.
<Director Jae-Hung Han of the Space Research Institute presenting>
The symposium was composed of a total of six sessions, including: ▲ Exchange Meeting on Additive Manufacturing Tecnology for Aerospace, ▲ International Workshop on Aerospace Composites, ▲ Workshop on Swarm Satellite Development, and ▲ Workshop on In-space Servicing and Manufacturing Robotics. Major domestic and foreign institutions and experts, including the Korea Aerospace Research Institute, Japan Advanced Institute of Science and Technology, and California Institute of Technology (Caltech), attended to discuss the future direction of next-generation space technology development and international cooperation measures. Cheol-woong Son, Director-General of Future Strategy Industry Office at Daejeon City, said, "We will develop the Innovative Research Center into a Daejeon-type space industry innovation platform with KAIST," and "Daejeon City will concentrate its capabilities to help local businesses grow and establish Daejeon as the central city for the Republic of Korea's space industry." Jae-Hung Han, Director of the KAIST Space Research Institute, said, "We will lead the core technologies for in-space servicing and manufacturing through cooperation between industry, academia, research institutes, and government, and contribute to the establishment of a private sector-focused industrial ecosystem," adding, "KAIST will grow into a comprehensive research hub that encompasses R&D, talent nurturing, and technology commercialization."
<Group Photo of Participants at the Opening Ceremony of the In-space Servicing and Manufacturing Research Center>
Kwang Hyung Lee, President of KAIST, said, "The field of in-space servicing and manufacturing is a core area that will change the paradigm of the future space industry," and "KAIST will lead the Republic of Korea to become the center for opening a new era of the space industry through innovative technology development and global cooperation." KAIST plans to perform the role of breaking down the boundaries between academia and industry, focusing on these technologies, and laying the foundation for next-generation space activities.
2025.10.24 View 2195 -
City AI Research Institute Selected for Ministry of Science and ICT's Brain Pool (BP) Institutional Recruitment Program
<Professor Yoonjin Yoon from the Department of Civil and Environmental Engineering at KAIST>
KAIST's City AI Research Institute (Director: Professor Yoonjin Yoon) has been selected for the Ministry of Science and ICT's Brain Pool (BP) Institutional Recruitment Program. This achievement is the culmination of a joint proposal spearheaded by Institute Director Professor Yoonjin Yoon, along with Professor Soyoung In of the Department of Civil and Environmental Engineering and Professor Sujin Han of the School of Electrical Engineering. It is the result of high praise for the institute's research capabilities in the field of Urban AI and its potential for international collaboration.
This BP project, with a total budget of 2.1 billion KRW, will be carried out over 28 months. It plans to actively pursue AI research focused on solving urban problems by inviting renowned overseas scholars to focus on three core areas: Geospatial AI, Climate AI, and Physical AI. Through this, the institute aims to develop core AI technologies based on a collaboration system involving industry, academia, research institutions, and government. This will lead the way in sustainable urban growth and the transition to an 'Cognitive City,' continuing research to proactively diagnose and respond to various issues that citizens can experience firsthand.
This project is particularly significant as it is a female-centered institutional Brain Pool project. KAIST plans to systematically support the growth of early-career female researchers and actively expand the participation of next-generation female scientists and engineers in international research networks. This is expected to significantly contribute to the development of female research personnel and the strengthening of research leadership, areas that are relatively lacking in domestic science and engineering fields.
Furthermore, through long-term joint research with researchers from world-leading universities such as MIT, NYU, UIUC, UBC, USF, and the University of Toronto, the City AI Research Institute is set to become a leading Urban AI research hub in Korea and Asia.
Moving forward, the institute will continue to dedicate itself to core research for responding to the complex challenges of future cities and advancing innovative technology through artificial intelligence, based on global cooperation.
2025.10.10 View 1133 -
2025 APEC Youth STEM Science Exchange Program Successfully Completed
<Photo1. Group photo at the end of the program>
KAIST (President Kwang Hyung Lee) announced on the 11thof August that it successfully hosted the 'APEC Youth STEM Conference KAIST Academic Program,' a global science exchange program for 28 youth researchers from 10 countries and over 30 experts who participated in the '2025 APEC Youth STEM* Collaborative Research and Competition.' The event was held at the main campus in Daejeon on Saturday, August 9.
STEM (Science, Technology, Engineering, Math) refers to the fields of science and engineering.
The competition was hosted by the Ministry of Science and ICT and organized by the APEC Science Gifted Mentoring Center. It took place from Wednesday, August 6, to Saturday, August 9, 2025, at KAIST in Daejeon and the Korea Science Academy of KAIST in Busan. The KAIST program was organized by the APEC Science Gifted Mentoring Center and supported by the KAIST Institute for the Gifted and Talented in Science Education.
Participants had the opportunity to experience Korea's cutting-edge research infrastructure firsthand, broaden their horizons in science and technology, and collaborate and exchange ideas with future science talents from the APEC region.
As the 2025 APEC chair, Korea is promoting various international collaborations to discover and nurture the next generation of talent in the STEM fields. The KAIST academic exchange program was particularly meaningful as it was designed with the international goal of revitalizing science gifted exchanges and expanding the basis for cooperation among APEC member countries. It moved beyond the traditional online-centric research collaboration model to focus on hands-on, on-site, and convergence research experiences.
The global science exchange program at KAIST introduced participants to KAIST's world-class educational and research environment and provided various academic content to allow them to experience real-world examples of convergence technology-based research.
<Photo2. Program Activities>
First, the KAIST Admissions Office participated, introducing KAIST's admissions system and its educational and research environment to outstanding international students, providing an opportunity to attract global talent. Following this, Dr. Tae-kyun Kwon of the Music and Audio Computing Lab at the Graduate School of Culture Technology presented a convergence art project based on musical artificial intelligence data, including a research demonstration in an anechoic chamber.
<Photo3. Participation in a music AI research demonstration>
Furthermore, a Climate Talk Concert program was organized under the leadership of the Graduate School of Green Growth and Sustainability, in connection with the theme of the APEC Youth STEM Collaborative Research: 'Youth-led STEM Solutions: Enhancing Climate Resilience.'
The program was planned and hosted by Dean Jiyong Eom. It provided a platform for young people to explore creative and practical STEM-based solutions to the climate crisis and seek opportunities for international cooperation.
<Photo4. Participation in Music AI Research Demonstration >
The program was a meaningful time for APEC youth researchers, offering practical support for their research through special lectures and Q&A sessions on:
Interdisciplinary Research and Education in the Era of Climate Crisis (Dean Jiyong Eom)
Energy Transition Technology in the Carbon Neutral Era (Professor Jeongrak Son)
Policies for Energy System Change (Professor Jihyo Kim)
Carbon Neutral Bio-technology (Professor Gyeongrok Choi)
After the afternoon talk concert, Lee Jing Jing, a student from Brunei, shared her thoughts, saying, "The lectures by the four professors were very meaningful and insightful. I was able to think about energy transition plans to solve climate change from various perspectives."
Si-jong Kwak, Director of the KAIST Global Institute for Talented Education, stated, "I hope that young people from all over the world will directly experience KAIST's research areas and environment, expand their interest in KAIST, and continue to grow as outstanding talents in the fields of science and engineering."
KAIST President Kwang Hyung Lee said, "KAIST will be at the center of science and technology-based international cooperation and will spare no effort to support future talents in developing creative and practical problem-solving skills. I hope this event served as an opportunity for young people to understand the value of global cooperation and grow into future science leaders."
2025.08.11 View 4285 -
KAIST Develops AI ‘MARIOH’ to Uncover and Reconstruct Hidden Multi-Entity Relationships
<(From Left) Professor Kijung Shin, Ph.D candidate Kyuhan Lee, and Ph.D candidate Geon Lee>
Just like when multiple people gather simultaneously in a meeting room, higher-order interactions—where many entities interact at once—occur across various fields and reflect the complexity of real-world relationships. However, due to technical limitations, in many fields, only low-order pairwise interactions between entities can be observed and collected, which results in the loss of full context and restricts practical use. KAIST researchers have developed the AI model “MARIOH,” which can accurately reconstruct* higher-order interactions from such low-order information, opening up innovative analytical possibilities in fields like social network analysis, neuroscience, and life sciences.
*Reconstruction: Estimating/reconstructing the original structure that has disappeared or was not observed.
KAIST (President Kwang Hyung Lee) announced on the 5th that Professor Kijung Shin’s research team at the Kim Jaechul Graduate School of AI has developed an AI technology called “MARIOH” (Multiplicity-Aware Hypergraph Reconstruction), which can reconstruct higher-order interaction structures with high accuracy using only low-order interaction data.
Reconstructing higher-order interactions is challenging because a vast number of higher-order interactions can arise from the same low-order structure.
The key idea behind MARIOH, developed by the research team, is to utilize multiplicity information of low-order interactions to drastically reduce the number of candidate higher-order interactions that could stem from a given structure.
In addition, by employing efficient search techniques, MARIOH quickly identifies promising interaction candidates and uses multiplicity-based deep learning to accurately predict the likelihood that each candidate represents an actual higher-order interaction.
<Figure 1. An example of recovering high-dimensional relationships (right) from low-dimensional paper co-authorship relationships (left) with 100% accuracy, using MARIOH technology.>
Through experiments on ten diverse real-world datasets, the research team showed that MARIOH reconstructed higher-order interactions with up to 74% greater accuracy compared to existing methods.
For instance, in a dataset on co-authorship relations (source: DBLP), MARIOH achieved a reconstruction accuracy of over 98%, significantly outperforming existing methods, which reached only about 86%. Furthermore, leveraging the reconstructed higher-order structures led to improved performance in downstream tasks, including prediction and classification.
According to Kijung, “MARIOH moves beyond existing approaches that rely solely on simplified connection information, enabling precise analysis of the complex interconnections found in the real world.” Furthermore, “it has broad potential applications in fields such as social network analysis for group chats or collaborative networks, life sciences for studying protein complexes or gene interactions, and neuroscience for tracking simultaneous activity across multiple brain regions.”
The research was conducted by Kyuhan Lee (Integrated M.S.–Ph.D. program at the Kim Jaechul Graduate School of AI at KAIST; currently a software engineer at GraphAI), Geon Lee (Integrated M.S.–Ph.D. program at KAIST), and Professor Kijung Shin. It was presented at the 41st IEEE International Conference on Data Engineering (IEEE ICDE), held in Hong Kong this past May.
※ Paper title: MARIOH: Multiplicity-Aware Hypergraph Reconstruction ※ DOI: https://doi.ieeecomputersociety.org/10.1109/ICDE65448.2025.00233
<Figure 2. An example of the process of recovering high-dimensional relationships using MARIOH technology>
This research was supported by the Institute of Information & Communications Technology Planning & Evaluation (IITP) through the project “EntireDB2AI: Foundational technologies and software for deep representation learning and prediction using complete relational databases,” as well as by the National Research Foundation of Korea through the project “Graph Foundation Model: Graph-based machine learning applicable across various modalities and domains.”
2025.08.05 View 2280 -
KAIST Holds '2025 KAIST Science Frontier Camp' for Multicultural Youth
<2025 KAIST Science Frontier Camp Activities>
KAIST (President Kwang Hyung Lee) announced on the 18th of July that it hosted the '2025 KAIST Science Frontier Camp' for multicultural youth from the 15th for three days and two nights at the Creative Learning Building on its main campus in Daejeon.
This event was organized in accordance with the 'Multicultural Talent Nurturing Agreement' signed by KAIST and GS Caltex in 2024. It marks the first year of a mid-to-long-term project in which 100 million KRW in development funds will be contributed annually for four years. The Global Institute for Talented Education organized the camp, and approximately 30 middle school students from multicultural families affiliated with the 'Hanmaum Educational Volunteer Group' (Director, Honorary Professor Byung Kyu Choi), a mentoring and volunteer organization for multicultural students, participated.
The camp participants enjoyed developing their scientific thinking skills and problem-solving abilities, and broadening their understanding of STEM (Science, Technology, Engineering, and Mathematics) career paths through a variety of science activity programs, including: △'Black Box: Record the Egg's Last Moment!' △'Find the Best Strategy! Heuristic Algorithm Challenge' △'Future Society and AI, Finding Career Directions' △'Distance Dominates the World!' and △'Career Talk Concert.'
During the opening ceremony, Director Byung Kyu Choi delivered a congratulatory speech. Additionally, Yong Hyun Kim, Dean of Admissions at KAIST, gave a special lecture titled 'La La Land KAIST – A Story of Chasing the Dream of a Young Scientist,' sharing honest stories about careers and dreams as a scientist.
Gi Jung Yoo, a freshman from the Division of Undeclared Majors who participated in the camp as a student mentor, shared that he had a very meaningful time mentoring the participating students, who are future STEM hopefuls, sharing vivid experiences as well as insights on metric functions. He added his hope that more students would be given such opportunities.
< Students Actively Taking Part in the Camp Activities>
Si Jong Kwak, Director of the Global Institute for Talented Education, stated, "We hope this will be a practical way to help students foster their interest in science, learn the joy of discussion and communication, and design their future."
KAIST President Kwang Hyung Lee remarked, "This camp was a valuable opportunity for students from diverse cultural backgrounds to gain confidence through science and envision their future." He added, "KAIST will continue to dedicate efforts to nurturing multicultural talent and contribute to creating a sustainable society."
Since 2024, KAIST has introduced and selected multicultural students through its Equal Opportunity Admission track. Utilizing the development funds from GS Caltex, KAIST also established the 'GS Caltex Multicultural Excellence Scholarship Program.' Through this scholarship program, undergraduate students from multicultural families receive living expenses each semester, allowing them to focus more stably on their studies. As the number of applicants for the Equal Opportunity Admission track is increasing every year, more multicultural students are expected to benefit from scholarships in the future.
Additionally, in May, both organizations invited Ms. Si Si Wu Fong, a foreign employee at GS Caltex, to give a special lecture titled 'Working Life for Foreigners in Korea' to support foreign students' career exploration. Foreign students who attended the lecture reported positive feedback, stating that they gained practical career information and were motivated to pursue employment in STEM fields in Korea.
KAIST plans to continue strengthening its efforts to nurture multicultural talent, increase understanding of the upcoming multicultural society, and help spread social values.
<At the 2025 KAIST Science Frontier Camp>
2025.07.18 View 2652 -
Distinguished Professor Sang Yup Lee Wins 2025 Global Metabolic Engineering Award
< Distinguished Professor Sang Yup Lee (Senior Vice President for Research) from the Department of Chemical & Biomolecular Engineering >
KAIST announced on the 20th that Professor Sang Yup Lee, who serves as the Vice President for Research and a Distinguished Professor at our university, has been awarded the '2025 Gregory N. Stephanopoulos Award for Metabolic Engineering' by the International Metabolic Engineering Society (IMES). Professor Lee delivered his award lecture at the 16th Metabolic Engineering Conference (ME16), held in Copenhagen, Denmark, from June 15th to 19th.
This award was established through contributions from the American Institute of Chemical Engineers (AIChE) Foundation, as well as fellow colleagues and acquaintances, to honor the achievements of Dr. Gregory Stephanopoulos, widely recognized as one of the pioneers of metabolic engineering. Presented biennially, the award recognizes scientists who have successfully commercialized fundamental research in metabolic engineering or have made outstanding contributions to the quantitative analysis, design, and modeling of metabolic pathways.
Professor Sang Yup Lee boasts an impressive record of over 770 journal papers and more than 860 patents. His groundbreaking research in metabolic engineering and biochemical engineering is highly acclaimed globally.
Throughout his 31 years as a professor at KAIST, Professor Lee has developed various metabolic engineering-based technologies and strategies. These advancements have been transferred to industries, facilitating the production of bulk chemicals, polymers, natural products, pharmaceuticals, and health functional foods. He has also founded companies and actively engages in advisory roles with various enterprises.
The International Metabolic Engineering Society (IMES) defines metabolic engineering as the manipulation of metabolic pathways in microorganisms or cells to produce useful substances (such as pharmaceuticals, biofuels, and chemical products). It utilizes tools like systems biology, synthetic biology, and computational modeling with the aim of enhancing the economic viability and sustainability of bio-based processes.
Furthermore, Professor Lee previously received the Merck Metabolic Engineering Award, a prominent international award in the field, in 2008. In 2018, he was honored with the Eni Award, often referred to as the Nobel Prize in energy, presented by the President of Italy.
Professor Sang Yup Lee remarked, "Metabolic engineering is a discipline that leads the current and future of biotechnology. It is a tremendous honor to receive this meaningful award at a time when the transition to a bio-based economy is accelerating. Together with my students and fellow researchers, we have generated numerous patents and transferred technologies to industry, and also established startups in the fields of biofuels, wound healing, and cosmetics. I will continue to pursue research that encompasses both fundamental research and technological commercialization."
The 'International Metabolic Engineering Society (IMES)' is a specialized society under the American Institute of Chemical Engineers. Its mission is to enable the production of various bio-based products, including pharmaceuticals, food additives, chemicals, and fuels, through metabolic engineering. The society hosts the Metabolic Engineering Conference biennially, offering researchers opportunities for knowledge exchange and collaboration.
2025.06.20 View 5401 -
“One Experiment Is All It Takes”: KAIST Team Revolutionizes Drug Interaction Testing, Replacing 60,000 Studies
A groundbreaking new method developed by researchers at KAIST and Chungnam National University could drastically streamline drug interaction testing — replacing dozens of traditional experiments with just one.
The research, led by Professor Jae Kyoung Kim of KAIST Department of Mathematical Sciences & IBS Biomedical Mathematics Group and Professor Sang Kyum Kim of Chungnam National University's College of Pharmacy, introduces a novel analysis technique called 50-BOA, published in Nature Communications on June 5, 2025.
< Photo 1. (From left) Professor Sang Kyum Kim (Chungnam National University College of Pharmacy, co-corresponding author), Dr. Yun Min Song (IBS Biomedical Mathematics Group, formerly KAIST Department of Mathematical Sciences, co-first author), undergraduate student Hyeong Jun Jang (KAIST, co-first author), Professor Jae Kyoung Kim (KAIST and IBS Biomedical Mathematics Group, co-corresponding author) (Top left in the bubble) Professor Hwi-yeol Yun (Chungnam National University College of Pharmacy, co-author) >
For decades, scientists have had to repeat drug inhibition experiments across a wide range of concentrations to estimate inhibition constants — a process seen in over 60,000 scientific publications. But the KAIST-led team discovered that a single, well-chosen inhibitor concentration can yield even more accurate results.
< Figure 1. Graphical summary of 50-BOA. 50-BOA improves the accuracy and efficiency of inhibition constant estimation by using only a single inhibitor concentration instead of the traditionally used method of employing multiple inhibitor concentrations. >
“This approach challenges long-standing assumptions in experimental pharmacology,” says Prof. Kim. “It shows how mathematics can fundamentally redesign life science experiments.”
By mathematically analyzing the sources of error in conventional methods, the team found that over half the data typically collected adds no value or even skews results. Their new method not only cuts experimental effort by over 75%, but also enhances reproducibility and accuracy.
To help researchers adopt the method quickly, the team developed a user-friendly tool that takes simple Excel files as input, now freely available on GitHub:
☞ https://github.com/Mathbiomed/50-BOA
< Figure 2. The MATLAB and R package of 50-BOA at GitHub >
The work holds promise for faster and more reliable drug development, especially in assessing potential interactions in combination therapies. The U.S. FDA already emphasizes the importance of accurate enzyme inhibition assessment during early-stage drug evaluation — and this method could soon become a new gold standard.
2025.06.16 View 6886 -
Professor Hyun Myung's Team Wins First Place in a Challenge at ICRA by IEEE
< Photo 1. (From left) Daebeom Kim (Team Leader, Ph.D. student), Seungjae Lee (Ph.D. student), Seoyeon Jang (Ph.D. student), Jei Kong (Master's student), Professor Hyun Myung >
A team of the Urban Robotics Lab, led by Professor Hyun Myung from the KAIST School of Electrical Engineering, achieved a remarkable first-place overall victory in the Nothing Stands Still Challenge (NSS Challenge) 2025, held at the 2025 IEEE International Conference on Robotics and Automation (ICRA), the world's most prestigious robotics conference, from May 19 to 23 in Atlanta, USA.
The NSS Challenge was co-hosted by HILTI, a global construction company based in Liechtenstein, and Stanford University's Gradient Spaces Group. It is an expanded version of the HILTI SLAM (Simultaneous Localization and Mapping)* Challenge, which has been held since 2021, and is considered one of the most prominent challenges at 2025 IEEE ICRA.*SLAM: Refers to Simultaneous Localization and Mapping, a technology where robots, drones, autonomous vehicles, etc., determine their own position and simultaneously create a map of their surroundings.
< Photo 2. A scene from the oral presentation on the winning team's technology (Speakers: Seungjae Lee and Seoyeon Jang, Ph.D. candidates of KAIST School of Electrical Engineering) >
This challenge primarily evaluates how accurately and robustly LiDAR scan data, collected at various times, can be registered in situations with frequent structural changes, such as construction and industrial environments. In particular, it is regarded as a highly technical competition because it deals with multi-session localization and mapping (Multi-session SLAM) technology that responds to structural changes occurring over multiple timeframes, rather than just single-point registration accuracy.
The Urban Robotics Lab team secured first place overall, surpassing National Taiwan University (3rd place) and Northwestern Polytechnical University of China (2nd place) by a significant margin, with their unique localization and mapping technology that solves the problem of registering LiDAR data collected across multiple times and spaces. The winning team will be awarded a prize of $4,000.
< Figure 1. Example of Multiway-Registration for Registering Multiple Scans >
The Urban Robotics Lab team independently developed a multiway-registration framework that can robustly register multiple scans even without prior connection information. This framework consists of an algorithm for summarizing feature points within scans and finding correspondences (CubicFeat), an algorithm for performing global registration based on the found correspondences (Quatro), and an algorithm for refining results based on change detection (Chamelion). This combination of technologies ensures stable registration performance based on fixed structures, even in highly dynamic industrial environments.
< Figure 2. Example of Change Detection Using the Chamelion Algorithm>
LiDAR scan registration technology is a core component of SLAM (Simultaneous Localization And Mapping) in various autonomous systems such as autonomous vehicles, autonomous robots, autonomous walking systems, and autonomous flying vehicles.
Professor Hyun Myung of the School of Electrical Engineering stated, "This award-winning technology is evaluated as a case that simultaneously proves both academic value and industrial applicability by maximizing the performance of precisely estimating the relative positions between different scans even in complex environments. I am grateful to the students who challenged themselves and never gave up, even when many teams abandoned due to the high difficulty."
< Figure 3. Competition Result Board, Lower RMSE (Root Mean Squared Error) Indicates Higher Score (Unit: meters)>
The Urban Robotics Lab team first participated in the SLAM Challenge in 2022, winning second place among academic teams, and in 2023, they secured first place overall in the LiDAR category and first place among academic teams in the vision category.
2025.05.30 View 10377 -
Editing Parkinson's Disease – KAIST Makes World's First Discovery of an Inflammatory RNA Editing Enzyme through Co-work with UCL Researchers
< Professor Minee Choi of the Department of Brain and Cognitive Sciences (top left). Professor Sonia Gandhi (top right) and Professor Klenerman of the University College London (bottom right) >
Parkinson's disease (PD) is a neurodegenerative disorder in which the α-synuclein protein abnormally aggregates within brain cells, causing neuronal damage. Through international collaboration, researchers at KAIST have revealed that RNA editing plays a crucial role in regulating neuroinflammation, a key pathology of Parkinson's disease.
KAIST (represented by President Kwang-Hyung Lee) announced on the 27th of April that a research team led by Professor Minee L. Choi from the Department of Brain and Cognitive Sciences, in collaboration with University College London (UCL) and the Francis Crick Institute, discovered that the RNA editing enzyme ADAR1 plays an important role in controlling immune responses in astrocytes, glial cells that trigger protective reactions in the brain, and demonstrated that this mechanism is critically involved in the progression of Parkinson’s disease.
Professor Choi's research team created a co-culture model composed of astrocytes and neurons derived from stem cells originating from Parkinson's disease patients, in order to study the inflammatory responses of brain immune cells. They then treated the model with α-synuclein aggregates, which are known to cause Parkinson’s disease, and analyzed how the immune cells' inflammatory responses changed.
< Figure 1. Schematic diagram of the inflammatory RNA editing model in Parkinson's disease >
As a result, it was found that early pathological forms of α-synuclein, known as oligomers, activated the Toll-like receptor pathway, which acts as a danger sensor in astrocytes, as well as the interferon response pathway, an immune signaling network that combats viruses and pathogens. During this process, the RNA editing enzyme ADAR1 was expressed and transformed into an isoform with an altered protein structure and function.
Notably, the RNA editing activity of ADAR1, which normally functions to regulate immune responses during viral infections by converting adenosine (A) to inosine (I) through a process known as A-to-I RNA editing, was found to be abnormally focused on genes that cause inflammation rather than operating under normal conditions. This phenomenon was observed not only in the patient-derived neuron models but also in postmortem brain tissues from actual Parkinson’s disease patients.
< Figure 2. Experimental design and inflammatory response induction in astrocytes following treatment with α-synuclein oligomers (abnormally folded protein fragments) >
This directly proves that the dysregulation of RNA editing induces chronic inflammatory responses in astrocytes, ultimately leading to neuronal toxicity and pathological progression.
This study is significant in that it newly identified the regulation of RNA editing within astrocytes as a key mechanism behind neuroinflammatory responses. In particular, it suggests that ADAR1 could serve as a novel genetic target for the treatment of Parkinson’s disease.
It is also noteworthy that the study reflected actual pathological characteristics of patients by utilizing patient-specific induced pluripotent stem cell-based precision models for brain diseases.
Professor Minee L. Choi stated, “This study demonstrates that the regulator of inflammation caused by protein aggregation operates at the new layer of RNA editing, offering a completely different therapeutic strategy from existing approaches to Parkinson's disease treatment." She further emphasized, “RNA editing technology could become an important turning point in the development of therapeutics for neuroinflammation.”
< Figure 3. When treated with α-synuclein oligomers, the causative agent of Parkinson's disease, A-to-I RNA editing is induced to change genetic information by ADAR in patient-derived stem cell-differentiated glial cells, confirming that α-synuclein is likely to be associated with the progression of Parkinson's disease through RNA editing >
This study was published in Science Advances on April 11, with Professor Choi listed as a co-first author.
Paper Title: Astrocytic RNA editing regulates the host immune response to alpha-synuclein, Science Advances Vol.11, Issue 15. (DOI:10.1126/sciadv.adp8504)
Lead Authors: Karishma D’Sa (UCL, Co-First Author), Minee L. Choi (KAIST, Co-First Author), Mina Ryten (UCL, Corresponding Author), Sonia Gandhi (Francis Crick Institute, University of Cambridge, Corresponding Author)
This research was supported by the Brain Research Program and the Excellent Young Researcher Program of the National Research Foundation of Korea, as well as KAIST’s Daekyo Cognitive Enhancement Program.
2025.05.02 View 8440 -
KAIST sends out Music and Bio-Signs of Professor Kwon Ji-yong, a.k.a. G-Dragon, into Space to Pulsate through Universe and Resonate among Stars
KAIST (President Kwang-Hyung Lee) announced on the 10th of April that it successfully promoted the world’s first ‘Space Sound Source Transmission Project’ based on media art at the KAIST Space Research Institute on April 9th through collaboration between Professor Jinjoon Lee of the Graduate School of Culture Technology, a world-renowned media artist, and the global K-Pop artist, G-Dragon.
This project was proposed as part of the ‘AI Entertech Research Center’ being promoted by KAIST and Galaxy Corporation. It is a project to transmit the message and sound of G-Dragon (real name, Kwon Ji-yong), a singer/song writer affiliated with Galaxy Corporation and a visiting professor in the Department of Mechanical Engineering at KAIST, to space for the first time in the world.
This is a convergence project that combines science, technology, art, and popular music, and is a new form of ‘space culture content’ experiment that connects KAIST’s cutting-edge space technology, Professor Jinjoon Lee’s media art work, and G-Dragon’s voice and sound source containing his latest digital single, "HOME SWEET HOME".
< Photo 1. Professor Jinjoon Lee's Open Your Eyes Project "Iris"'s imagery projected on the 13m space antenna at the Space Research Institute >
This collaboration was planned with the theme of ‘emotional signals that expand the inner universe of humans to the outer universe.’ The image of G-Dragon’s iris was augmented through AI as a window into soul symbolizing his uniqueness and identity, and the new song “Home Sweet Home” was combined as an audio message containing the vibration of that emotion.
This was actually transmitted into space using a next-generation small satellite developed by KAIST Space Research Institute, completing a symbolic performance in which an individual’s inner universe is transmitted to outer space.
Professor Jinjoon Lee’s cinematic media art work “Iris” was unveiled at the site. This work was screened in the world’s first projection mapping method* on KAIST Space Research Institute’s 13m space antenna. This video was created using generative artificial intelligence (AI) technology based on the image of G-Dragon's iris, and combined with sound using the data of the sounds of Emile Bell rings – the bell that holds a thousand years of history, it presented an emotional art experience that transcends time and space.
*Projection Mapping: A technology that projects light and images onto actual structures to create visual changes, and is a method of expression that artistically reinterprets space.
This work is one of the major research achievements of KAIST TX Lab and Professor Lee based on new media technology based on biometric data such as iris, heartbeat, and brain waves.
Professor Jinjoon Lee said, "The iris is a symbol that reflects inner emotions and identity, so much so that it is called the 'mirror of the soul,' and this work sought to express 'the infinite universe seen from the inside of humanity' through G-Dragon's gaze."
< Photo 2. (From left) Professor Jinjoon Lee of the Graduate School of Culture Technology and G-Dragon (Visiting Professor Kwon Ji-yong of the Department of Mechanical Engineering) >
He continued, "The universe is a realm of technology as well as a stage for imagination and emotion, and I look forward to an encounter with the unknown through a new attempt to speak of art in the language of science including AI and imagine science in the form of art." “G-Dragon’s voice and music have now begun their journey to space,” said Yong-ho Choi, Galaxy Corporation’s Chief Happiness Officer (CHO). “This project is an act of leaving music as a legacy for humanity, while also having an important meaning of attempting to communicate with space.” He added, “This is a pioneering step to introduce human culture to space, and it will remain as a monumental performance that opens a new chapter in the history of music comparable to the Beatles.”
Galaxy Corporation is leading the future entertainment technology industry through its collaboration with KAIST, and was recently selected as the only entertainment technology company in a private meeting with Microsoft CEO Nadella. In particular, it is promoting the globalization of AI entertainment technology, receiving praise as a “pioneer of imagination” for new forms of AI entertainment content, including the AI contents for the deceased.
< Photo 3. Photo of G-Dragon's Home Sweet Home being sent into the space via Professor Jinjoon Lee's Space Sound Source Transmission Project >
Through this project, KAIST Space Research Institute presented new possibilities for utilizing satellite technology, and showed a model for science to connect with society in a more popular way.
KAIST President Kwang-Hyung Lee said, “KAIST is a place that always supports new imaginations and challenges,” and added, “We will continue to strive to continue creative research that no one has ever thought of, like this project that combines science, technology, and art.”
In the meantime, Galaxy Corporation, the agency of G-Dragon’s Professor Kwon Ji-yong, is an AI entertainment company that presents a new paradigm based on IP, media, tech, and entertainment convergence technology.
2025.04.10 View 9797