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AI, Humanoid Robots, and Space Rovers to Gather: Experience Future Technologies at the Science Festival
<(From left) Photos of the KAIST Science Festival exhibition hall and booths from the previous year>
KAIST announced on April 10th that KAIST will participate in the ‘2026 Korea Science and Technology Festival,’ the largest science festival in the country, to mark Science Month in April. KAIST will operate ‘KAIST Play World,’ an interactive exhibition hall showcasing the pinnacle of AI and robotics. This year’s festival will be held in two parts: ‘2026 Korea Science Festival in Daejeon (April 17–19)’ and ‘2026 Korea Science Festival in Gyeonggi (April 24–26).’ KAIST will host consecutive exhibitions at the Daejeon DCC (Second Exhibition Hall) and KINTEX in Ilsan. Under the ‘Play World’ concept, KAIST plans to offer differentiated interactive content tailored to various generations. In particular, on-site events and souvenirs featuring the KAIST character ‘Nupjuk-i’ will be provided to enhance visitor engagement.
□ [Daejeon] From Humanoid Robots to Space Rovers and AI Semiconductor Friend ‘BROCA’ The exhibition at Daejeon DCC from April 17 to 19 will feature ‘Future Tech Experience Content’ centered on advanced robotics, space technology, and AI semiconductor technology, allowing visitors to experience KAIST's core research achievements firsthand. First, a humanoid robot equipped with control technology developed by Eurobotics Co., Ltd., a startup from Professor Myung Hyun’s research team in the School of Electrical Engineering, will be unveiled on the 17th. This robot is gaining attention as a next-generation platform capable of natural walking in both industrial and urban environments. Additionally, on the 19th, a humanoid robot from Professor Park Hae-won’s team in the Department of Mechanical Engineering will demonstrate high-difficulty human movements such as the duck walk and moonwalk, showcasing its potential for practical industrial use. Professor Lee Dae-young’s team in the Department of Aerospace Engineering will present the world’s first deployable lunar rover wheel based on origami technology. Visitors can touch the transformable wheel model and observe space rover demonstrations and displays by the co-developer, Unmanned Exploration Laboratory (UEL). Educational sessions for folding various space systems using origami will also be available. Along with this, visitors can experience advanced human-machine interaction through ‘BROCA,’ a mobile social AI agent that builds relationships with users beyond simple Q&A, and the voice-capable guide robot ‘On-Newro,’ developed by Professor Yoo Hoi-jun’s team at the AI Semiconductor Graduate School. The student startup ‘Liar Games’ will operate a trial zone for ‘Dual Focus,’ an abstract strategy board game where players compete 1:1 against AI. Similar to the deep strategic play of chess or Go, the rules are intuitive enough to learn in 5 minutes, which is expected to stimulate the challenge-seeking spirit of visitors.
< (Top row from left) Professor Park Hae-won’s humanoid robot, Professor Yoo Hoi-jun’s BROCA, (Bottom row from left) Eurobotics’ humanoid walking technology capable of overcoming any terrain based on a mobile kit, Professor Lee Dae-young’s storable and deployable rover for lunar exploration >
□ [Gyeonggi] ‘Raibo’ the Rough-Terrain Robot and AI-Based Future Experiences The Gyeonggi exhibition at KINTEX from April 24 to 26 will focus on ‘Life-Oriented Experience Content’ centered on AI and everyday technology. ‘Raibo,’ a quadrupedal robot developed by Professor Hwangbo Jemin’s team in the Department of Mechanical Engineering, is capable of high-speed movement on complex terrains such as sand, stairs, and debris, and is expected to be utilized for disaster relief and search missions. Visitors can experience Raibo’s driving technology directly at the site. The ‘Future Memories Studio’ from Professor Nam Tek-jin’s team in the Department of Industrial Design will provide a new experience where visitors can meet and talk to their future selves 10 years later, recreated using AI-generated visuals and voices. Participants will receive a four-cut photo capturing a moment that is the future for their current self but a memory for their future self. Professor Yun Yun-jin’s team at the KAIST Urban AI Research Center will present technology that analyzes the impact of climate change on small business sales through ‘AI-based Sight and Sound for Heatwave Consumption Index.’ They will showcase time-series AI-based sales prediction technology and generative AI technology that expresses this visually and audibly. Furthermore, Professor Yun’s lecture, “City Walk of Artificial Intelligence: Urban AI and the Future of Cities,” will be held on April 24 (Fri) at 15:00 in KINTEX Meeting Room 206. In addition, Professor Yoo Hoi-jun’s team from the AI Semiconductor Graduate School will continue from the Daejeon exhibition to operate an experience zone for various mobile AI agents based on AI semiconductors. Also, the student startup Rabbithole Company will introduce a new type of game where AI NPCs (Non-Player Characters) converse and cooperate to solve given problems. Visitors can participate by observing the process where AI characters create their own stories by being presented with situations or goals instead of being directly controlled.
< (Top row from left) Professor Hwangbo Jemin’s Raibo, Professor Nam Tek-jin’s team: Met My Future Self 10 Years Later, (Bottom row from left) Professor Yun Yun-jin’s Seeing and Hearing Heatwave Consumption Index through AI, Game image from CEO Kim Na-hoon’s Rabbithole Company >
Through the exhibitions in both regions, KAIST plans to operate various participatory programs to make science and technology easy and fun to approach, vividly conveying how technology from the laboratory transforms our lives. KAIST President Lee Kwang-hyung remarked, “This year’s science festival is a large-scale event connecting Daejeon and Gyeonggi, allowing more citizens to experience KAIST’s innovative research achievements firsthand.” He added, “I hope this will be a precious time for people to experience the future created by robots and AI, fostering their dreams and curiosity about science.”
2026.04.13 View 442 -
KAIST Reveals the Orbital Principle of Electron Motion for Realizing Memory of Dreams
<(From Left) Dr. Geun-Hee Lee, Professor Kyung-Jin Lee, Professor Kyoung-Whan Kim>
Research is actively underway to develop a “dream memory” that can reduce heat generation in smartphones and laptops while delivering faster performance and lower power consumption. Korean researchers have now proposed a new possibility for controlling magnetism using the exchange interaction of electron orbitals—the motion of electrons orbiting around an atomic nucleus—rather than relying on the conventional exchange interaction of electron spin, the rotational property of electrons inside semiconductors.
KAIST (President Kwang Hyung Lee) announced on the 16th of March that a joint research team led by Professor Kyung-Jin Lee of the Department of Physics at KAIST and Professor Kyoung-Whan Kim of the Department of Physics at Yonsei University (President Dong-Sup Yoon) has established, for the first time in the world, a new theoretical framework enabling magnetism to be freely controlled through orbital exchange interaction*, surpassing the limitations of conventional technologies that control magnetism using electric currents.*Orbital exchange interaction: a phenomenon in which the orbitals formed by electrons moving around an atomic nucleus interact with one another, thereby influencing the direction or properties of magnetism.
Until now, next-generation memory research has mainly focused on the spin of electrons. Spin refers to the property of electrons that rotate on their own axis like tiny spinning tops, and information can be stored by using the direction of this rotation. However, electrons simultaneously move around the atomic nucleus along paths known as orbitals. In this study, the research team theoretically demonstrated that when electric current flows, the orbital energy of electrons interacts directly with the orbitals of magnetic materials, enabling the transmission of information. Through this mechanism, they confirmed that the properties of magnets can be altered much more efficiently than with conventional spin-based approaches.
The most significant outcome of this research is the discovery that electric current does not merely change the direction of a magnet but can also modify the intrinsic properties of the magnet itself, such as the magnetic anisotropy (a magnet’s preferred direction) and rotational characteristics.
In particular, calculations by the research team showed that orbital-based control effects could be significantly stronger than existing spin-based methods. This finding suggests the possibility of a future era of orbital-based electronic devices, in which orbitals rather than spin play the central role in semiconductor components. The researchers also proposed practical experimental methods to measure these effects, which is expected to increase the potential for industrial applications.
The principle may also apply to altermagnetic materials, which have recently attracted significant attention in academia. Altermagnetism refers to a new form of magnetic material in which electron spins within atoms are arranged in alternating directions in an ordered pattern. Although these materials do not appear magnetic externally, they strongly influence electron motion. Because of this property, they allow precise control of electron states and are considered promising for high-speed, low-power semiconductor devices and next-generation memory technologies. The study therefore provides a strong theoretical foundation for developing future logic and memory devices.
Dr. Geun-Hee Lee stated, “This study demonstrates that controlling magnetism with electric current does not necessarily have to rely solely on spin. A new perspective—understanding and controlling magnetism using the orbital motion of electrons—will become an important milestone for the development of next-generation ultra-fast, low-power memory.”
In this research, Dr. Geun-Hee Lee (KAIST) participated as the first author, while Professor Kyoung-Whan Kim (Yonsei University) and Professor Kyung-Jin Lee (KAIST) served as co-corresponding authors. The results were published on February 2 in the internationally renowned journal Nature Communications, recognizing the academic significance of the work.
※ Paper title: “Orbital exchange-mediated current control of magnetism,” DOI: https://doi.org/10.1038/s41467-026-68846-x
This research was supported by the Frontier Challenge R&D Project, the Mid-Career Researcher Program, the Science Research Center (SRC) program, the Early Career Researcher Program of the National Research Foundation of Korea, and Samsung Electronics.
2026.03.16 View 730 -
Failure in the AI Era? The 3rd Failure Conference Held
< 2025 Failure Conference Poster >
KAIST announced on the 31st of October that it will be holding the '3rd Failure Conference' from Wednesday, November 5th to Friday, November 14th. The event is organized by the KAIST Center for Ambitious Failure (Director Sungho Jo), and, under the theme 'AI times Failure,' it will re-examine the value of humaneness through the sensibility of 'failure' in this era of great transformation led by AI technology.
Composed of lectures, competitions, exhibitions, and networking programs, this conference provides a venue for new introspection on the relationship between humanity, society, and technology through the lens of 'failure.'
Failure Seminar 'AI Era, Asking the Way of Humanity' will be held on November 6th at the Jeong Geun-mo Conference Hall in the Academic and Cultural Complex
Professor Juho Kim of the KAIST School of Computing will discuss the human sensibility and resilience needed in the AI era through the paradox that "AI learns how to fail less, but humans are losing the opportunity to fail. Following this, Professor Sang Wook Lee of the Hanyang University Department of Philosophy will present philosophical and ethical challenges and practical directions for the advancement of AI technology to lead to universal welfare for humanity. The 'AI times Failure Idea Contest' Finals will take place on November 7th at the John Hanner Hall in the Academic and Cultural Complex. 12 teams, selected from preliminaries that included 111 teams from universities and graduate schools nationwide, will demonstrate their ideas in booth form on the theme of 'The Future where AI and Humans Coexist.' Participants will explore AI errors, human limitations, and the possibility of trust and recovery, presenting attempts to convert technological failure into human introspection, and human failure into technological possibility. On the day of the finals, the Grand Prize (KAIST President’s Award), First Prize, and Second Prize will be selected through judging.
The Photography Exhibition '404: Perfection Not Found' will be held on the 1st floor of the Creative Learning Building from November 5th to 14th. This exhibition showcases 'Scenes of Imperfection' captured by KAIST members through the PhotoVoice program and the AI times Failure Snapshot Challenge. It is divided into three sections: ▲ Brain that Mimics Perfection: Failure of AI ▲ Incomplete Connection: Portrait of the Digital Generation ▲ Aesthetics of Imperfection: Warmth of Humanity, providing a space for introspection that illuminates human responsibility and potential through technological failure. The 'Show Off Your Failed Project Contest,' which has garnered great response from KAIST students every year, will be expanded to include general public participation on the 5th at the John Hanner Hall in the Academic and Cultural Complex. Co-planned by the KAIST Center for Ambitious Failure and the student club ICISTS, participants will decorate their own booths with photos and videos to share their failures and the process of overcoming them. Awards such as ▲ Best (Most Votes) ▲ Shining Debris Award (Highly Relatable Failure Story) ▲ Flower of Ash Award (Overcoming Story) ▲ Aesthetics of Failure Award (Creative Expression) ▲ Beautiful Afterimage Award (Sincere Lingering Impression) will be selected through audience voting.
< 2025 Show Off Your Failed Project Contest Poster >
Sungho Jo, KAIST Center for Ambitious Failure (Professor, School of Computing), stated, "As AI technology rapidly evolves and changes the order of the world, humans need to look back at themselves beyond that speed. I hope this Failure Conference will be an opportunity to rediscover the meaning of humaneness amid technological innovation and to imagine a better future." Kwang Hyung Lee, President of KAIST, said, "Failure is another name for challenge, and a seed of innovation. KAIST will lead the AI era and human-centered technological development through a creative spirit of challenge that is not afraid of failure."
All programs for the 2025 Failure Conference are open to anyone interested, and detailed schedules and content can be checked on the webstie of KAIST Center for Ambitious Failure (caf.kaist.ac.kr).
2025.10.29 View 1930 -
“One Experiment Is All It Takes”: KAIST Team Revolutionizes Drug Interaction Testing, Replacing 60,000 Studies
A groundbreaking new method developed by researchers at KAIST and Chungnam National University could drastically streamline drug interaction testing — replacing dozens of traditional experiments with just one.
The research, led by Professor Jae Kyoung Kim of KAIST Department of Mathematical Sciences & IBS Biomedical Mathematics Group and Professor Sang Kyum Kim of Chungnam National University's College of Pharmacy, introduces a novel analysis technique called 50-BOA, published in Nature Communications on June 5, 2025.
< Photo 1. (From left) Professor Sang Kyum Kim (Chungnam National University College of Pharmacy, co-corresponding author), Dr. Yun Min Song (IBS Biomedical Mathematics Group, formerly KAIST Department of Mathematical Sciences, co-first author), undergraduate student Hyeong Jun Jang (KAIST, co-first author), Professor Jae Kyoung Kim (KAIST and IBS Biomedical Mathematics Group, co-corresponding author) (Top left in the bubble) Professor Hwi-yeol Yun (Chungnam National University College of Pharmacy, co-author) >
For decades, scientists have had to repeat drug inhibition experiments across a wide range of concentrations to estimate inhibition constants — a process seen in over 60,000 scientific publications. But the KAIST-led team discovered that a single, well-chosen inhibitor concentration can yield even more accurate results.
< Figure 1. Graphical summary of 50-BOA. 50-BOA improves the accuracy and efficiency of inhibition constant estimation by using only a single inhibitor concentration instead of the traditionally used method of employing multiple inhibitor concentrations. >
“This approach challenges long-standing assumptions in experimental pharmacology,” says Prof. Kim. “It shows how mathematics can fundamentally redesign life science experiments.”
By mathematically analyzing the sources of error in conventional methods, the team found that over half the data typically collected adds no value or even skews results. Their new method not only cuts experimental effort by over 75%, but also enhances reproducibility and accuracy.
To help researchers adopt the method quickly, the team developed a user-friendly tool that takes simple Excel files as input, now freely available on GitHub:
☞ https://github.com/Mathbiomed/50-BOA
< Figure 2. The MATLAB and R package of 50-BOA at GitHub >
The work holds promise for faster and more reliable drug development, especially in assessing potential interactions in combination therapies. The U.S. FDA already emphasizes the importance of accurate enzyme inhibition assessment during early-stage drug evaluation — and this method could soon become a new gold standard.
2025.06.16 View 8421 -
<Big Coins> Exhibition: Where Coins and Imagination Collide - Held at SUPEX Hall, KAIST Seoul Campus
KAIST (President Kwang-Hyung Lee) announced on May 19th the opening of the solo exhibition, “Big Coins,” by photographer and media artist Hojun Ji (Adjunct Professor, Department of Industrial Design) at the SUPEX Hall in the Business School of the Seoul Campus. The exhibition will run from May 19th to the end of February of the following year.
This exhibition at the KAIST Seoul Campus Business School presents artworks with an insightful perspective, inviting diverse interpretations from the audience. Notable pieces include ‘Priced,’ which juxtaposes Leonardo da Vinci's ‘Salvator Mundi,’ sold for approximately 450 million US dollars at a 2017 auction, with a Vatican coin bearing the image of Pope John XXIII. Another work, ‘Ciphered,’ superimposes a code used by the German army during World War II onto a Swiss coin featuring Helvetia.
< Priced, 150x150cm, 2025 >
Currently, Hojun Ji, an Adjunct Professor in KAIST’s Department of Industrial Design (and a student at the KAIST Graduate School of Culture Technology), creates his art using images captured by observing everyday objects through optical or electron microscopes.
He has garnered particular attention for his unique artistic world, which combines enlarged microscopic photographs of coins from across the globe with significant news articles from modern and contemporary history.
Yeo-sun Yoon, Dean of the College of Business Administration, commented, “While the KAIST Art Museum is located at the main campus in Daejeon, the College of Business Administration here on the Seoul Campus also regularly hosts exhibitions curated by the museum. I am delighted to encounter a new realm of art through this solo exhibition by Artist Hojun Ji.”
< Ciphered, 150x150cm, 2025 >
Hyeon-Jeong Suk, Director of the Art Museum and a Full Professor in KAIST’s Department of Industrial Design, remarked, “Professor Hojun Ji's experimental imagination is remarkably unique and eccentric. As a graduate student, he connected data from his observations of his lab dog’s droppings with Jeong Seon's <Geumgang Jeondo>. Such imaginative thinking exemplifies the direction KAIST is pursuing.”
Artist Hojun Ji stated, “The coins I examined through optical and electron microscopes were not merely a form of payment but rather portraits of humanity etched with time and power. The history and memories embedded in their fine cracks and textures resonated with me as a singular sculpture. I aim to unlock the vast world of imagination concealed within these small pieces of metal.”
< Geumgang Byeondo: a Variation of the View of Mt. Geumgang (a twist of Geumgang Jeondo - a Complete View of Geumgangsan Mountain, 1734), 80x120cm, 2009 >
Ji has presented experimental works that transcend the boundaries of science and art through numerous exhibitions both domestically and internationally. His work has also been featured on the cover of the international academic journal Digital Creativity and is increasingly recognized for its artistic merit, with pieces housed in the Embassy of the Republic of Korea in Turkey, the Seoul Museum of Art, and the 9/11 Memorial Center in the United States.
This solo exhibition, which will continue until the end of February of next year, is open to KAIST members and external visitors free of charge.
2025.05.20 View 6863 -
KAIST Identifies Master Regulator Blocking Immunotherapy, Paving the Way for a New Lung Cancer Treatment
Immune checkpoint inhibitors, a class of immunotherapies that help immune cells attack cancer more effectively, have revolutionized cancer treatment. However, fewer than 20% of patients respond to these treatments, highlighting the urgent need for new strategies tailored to both responders and non-responders.
KAIST researchers have discovered that 'DEAD-box helicases 54 (DDX54)', a type of RNA-binding protein, is the master regulator that hinders the effectiveness of immunotherapy—opening a new path for lung cancer treatment. This breakthrough technology has been transferred to faculty startup BioRevert Inc., where it is currently being developed as a companion therapeutic and is expected to enter clinical trials by 2028.
< Photo 1. (From left) Researcher Jungeun Lee, Professor Kwang-Hyun Cho and Postdoctoral Researcher Jeong-Ryeol Gong of the Department of Bio and Brain Engineering at KAIST >
KAIST (represented by President Kwang-Hyung Lee) announced on April 8 that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering had identified DDX54 as a critical factor that determines the immune evasion capacity of lung cancer cells. They demonstrated that suppressing DDX54 enhances immune cell infiltration into tumors and significantly improves the efficacy of immunotherapy.
Immunotherapy using anti-PD-1 or anti-PD-L1 antibodies is considered a powerful approach in cancer treatment. However, its low response rate limits the number of patients who actually benefit.
To identify likely responders, tumor mutational burden (TMB) has recently been approved by the FDA as a key biomarker for immunotherapy. Cancers with high mutation rates are thought to be more responsive to immune checkpoint inhibitors. However, even tumors with high TMB can display an “immune-desert” phenotype—where immune cell infiltration is severely limited—resulting in poor treatment responses.
< Figure 1. DDX54 was identified as the master regulator that induces resistance to immunotherapy by orchestrating suppression of immune cell infiltration through cancer tissues as lung cancer cells become immune-evasive >
Professor Kwang-Hyun Cho's research team compared transcriptome and genome data of lung cancer patients with immune evasion capabilities through gene regulatory network analysis (A) and discovered DDX54, a master regulator that induces resistance to immunotherapy (B-F).
This study is especially significant in that it successfully demonstrated that suppressing DDX54 in immune-desert lung tumors can overcome immunotherapy resistance and improve treatment outcomes.
The team used transcriptomic and genomic data from immune-evasive lung cancer patients and employed systems biology techniques to infer gene regulatory networks. Through this analysis, they identified DDX54 as a central regulator in the immune evasion of lung cancer cells.
In a syngeneic mouse model, the suppression of DDX54 led to significant increases in the infiltration of anti-cancer immune cells such as T cells and NK cells, and greatly improved the response to immunotherapy.
Single-cell transcriptomic and spatial transcriptomic analyses further showed that combination therapy targeting DDX54 promoted the differentiation of T cells and memory T cells that suppress tumors, while reducing the infiltration of regulatory T cells and exhausted T cells that support tumor growth.
< Figure 2. In the syngeneic mouse model made of lung cancer cells, it was confirmed that inhibiting DDX54 reversed the immune-evasion ability of cancer cells and enhanced the sensitivity to anti-PD-1 therapy >
In a syngeneic mouse model made of lung cancer cells exhibiting immunotherapy resistance, the treatment applied after DDX54 inhibition resulted in statistically significant inhibition of lung cancer growth (B-D) and a significant increase in immune cell infiltration into the tumor tissue (E, F).
The mechanism is believed to involve DDX54 suppression inactivating signaling pathways such as JAK-STAT, MYC, and NF-κB, thereby downregulating immune-evasive proteins CD38 and CD47. This also reduced the infiltration of circulating monocytes—which promote tumor development—and promoted the differentiation of M1 macrophages that play anti-tumor roles.
Professor Kwang-Hyun Cho stated, “We have, for the first time, identified a master regulatory factor that enables immune evasion in lung cancer cells. By targeting this factor, we developed a new therapeutic strategy that can induce responsiveness to immunotherapy in previously resistant cancers.”
He added, “The discovery of DDX54—hidden within the complex molecular networks of cancer cells—was made possible through the systematic integration of systems biology, combining IT and BT.”
The study, led by Professor Kwang-Hyun Cho, was published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on April 2, 2025, with Jeong-Ryeol Gong being the first author, Jungeun Lee, a co-first author, and Younghyun Han, a co-author of the article.
< Figure 3. Single-cell transcriptome and spatial transcriptome analysis confirmed that knockdown of DDX54 increased immune cell infiltration into cancer tissues >
In a syngeneic mouse model made of lung cancer cells that underwent immunotherapy in combination with DDX54 inhibition, single-cell transcriptome (H-L) and spatial transcriptome (A-G) analysis of immune cells infiltrating inside cancer tissues were performed. As a result, it was confirmed that anticancer immune cells such as T cells, B cells, and NK cells actively infiltrated the core of lung cancer tissues when DDX54 inhibition and immunotherapy were concurrently administered.
(Paper title: “DDX54 downregulation enhances anti-PD1 therapy in immune-desert lung tumors with high tumor mutational burden,” DOI: https://doi.org/10.1073/pnas.2412310122)
This work was supported by the Ministry of Science and ICT and the National Research Foundation of Korea through the Mid-Career Research Program and Basic Research Laboratory Program.
< Figure 4. The identified master regulator DDX54 was confirmed to induce CD38 and CD47 expression through Jak-Stat3, MYC, and NF-κB activation. >
DDX54 activates the Jak-Stat3, MYC, and NF-κB pathways in lung cancer cells to increase CD38 and CD47 expression (A-G). This creates a cancer microenvironment that contributes to cancer development (H) and ultimately induces immune anticancer treatment resistance.
< Figure 5. It was confirmed that an immune-inflamed environment can be created by combining DDX54 inhibition and immune checkpoint inhibitor (ICI) therapy. >
When DDX54 inhibition and ICI therapy are simultaneously administered, the cancer cell characteristics change, the immune evasion ability is restored, and the environment is transformed into an ‘immune-activated’ environment in which immune cells easily infiltrate cancer tissues. This strengthens the anticancer immune response, thereby increasing the sensitivity of immunotherapy even in lung cancer tissues that previously had low responsiveness to immunotherapy.
2025.04.08 View 13829 -
KAIST Proves Possibility of Preventing Hair Loss with Polyphenol Coating Technology
- KAIST's Professor Haeshin Lee's research team of the Department of Chemistry developed tannic scid-based hair coating technology
- Hair protein (hair and hair follicle) targeting delivery technology using polyphenol confirms a hair loss reduction effect of up to 90% to manifest within 7 Days
- This technology, first applied to 'Grabity' shampoo, proves effect of reducing hair loss chemically and physically
< Photo. (From left) KAIST Chemistry Department Ph.D. candidate Eunu Kim, Professor Haeshin Lee >
Hair loss is a problem that hundreds of millions of people around the world are experiencing, and has a significant psychological and social impact. KAIST researchers focused on the possibility that tannic acid, a type of natural polyphenol, could contribute to preventing hair loss, and through research, discovered that tannic acid is not a simple coating agent, but rather acts as an 'adhesion mediator' that alleviates hair loss.
KAIST (President Kwang-Hyung Lee) announced on the 6th that the Chemistry Department Professor Haeshin Lee's research team developed a new hair loss prevention technology that slowly releases hair loss-alleviating functional ingredients using tannic acid-based coating technology.
Hair loss includes androgenetic alopecia (AGA) and telogen effluvium (TE), and genetic, hormonal, and environmental factors work together, and there is currently a lack of effective treatments with few side effects.
Representative hair loss treatments, minoxidil and finasteride, show some effects, but require long-term use, and not only do their effects vary depending on the body type, but some users also experience side effects.
Professor Haeshin Lee's research team proved that tannic acid can strongly bind to keratin, the main protein in hair, and can be continuously attached to the hair surface, and confirmed that this can be used to release specific functional ingredients in a controlled manner.
In particular, the research team developed a combination that included functional ingredients for hair loss relief, such as salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL), and named it 'SCANDAL.' The research results showed that the Scandal complex combined with tannic acid is gradually released when it comes into contact with water and is delivered to the hair follicles along the hair surface.
< Figure 1. Schematic diagram of the hair loss relief mechanism by the tannic acid/SCANDAL complex. Tannic acid is a polyphenol compound containing a galol group that has a 360-degree adhesive function, and it binds to the hair surface on one side and binds to the hair loss relief functional ingredient SCANDAL on the other side to store it on the hair surface. Afterwards, when it comes into contact with moisture, SCANDAL is gradually released and delivered to the scalp and hair follicles to show the hair loss relief effect. >
The research team of Goodmona Clinic (Director: Geon Min Lee) applied the shampoo containing tannic acid/Scandal complex to 12 hair loss patients for 7 days, and observed a significant hair loss reduction effect in all clinicians. The results of the experiment showed a reduction in average hair loss of 56.2%, and there were cases where hair loss was reduced by up to 90.2%.
This suggests that tannic acid can be effective in alleviating hair loss by stably maintaining the Scandal component on the hair surface and gradually releasing it and delivering it to the hair follicles.
< Figure 2. When a tannic acid coating is applied to untreated bleached hair, a coating is formed as if the cuticles are tightly attached to each other. This was confirmed through X-ray photoelectron spectroscopy (XPS) analysis, and a decrease in signal intensity was observed in the surface analysis of nitrogen of amino acids contained in keratin protein after tannic acid coating. This proves that tannic acid successfully binds to the hair surface and covers the existing amino acids. To verify this more clearly, the oxidation-reduction reaction was induced through gold ion treatment, and as a result, the entire hair turned black, and it was confirmed that tannic acid reacted with gold ions on the hair surface to form a tannic acid-gold complex. >
Professor Haeshin Lee said, “We have successfully proven that tannic acid, a type of natural polyphenol, has a strong antioxidant effect and has the property of strongly binding to proteins, so it can act as a bio-adhesive.”
Professor Lee continued, “Although there have been cases of using it as a skin and protein coating material in previous studies, this study is the first case of combining with hair and delivering hair loss relief ingredients, and it was applied to ‘Grabity’ shampoo commercialized through Polyphenol Factory, a startup company. We are working to commercialize more diverse research results, such as shampoos that dramatically increase the strength of thin hair that breaks and products that straighten curly hair.”
< Figure 3. Tannic acid and the hair loss relief functional ingredient (SCANDAL) formed a stable complex through hydrogen bonding, and it was confirmed that tannic acid bound to the hair could effectively store SCANDAL. In addition, the results of transmission electron microscopy analysis of salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL) showed that all of them formed tannic acid-SCANDAL nanocomplexes. >
The results of this study, in which a Ph.D. candidate KAIST Department of Chemistry, Eunu Kim, was the first author and Professor Haeshin Lee was the corresponding author, were published in the online edition of the international academic journal ‘Advanced Materials Interfaces’ on January 6. (Paper title: Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation) DOI: 10.1002/admi.202400851
< Figure 4. The hair loss relief functional ingredient (SCANDAL) stored on the hair surface with tannic acid was slowly released upon contact with moisture and delivered to the hair follicle along the hair surface. Salicylic acid (SCA) and niacinamide (N) were each released by more than 25% within 10 minutes. When shampoo containing tannic acid/SCANDAL complex was applied to the hair of 12 participants, hair loss was reduced by about 56.2% on average, and the reduction rate ranged from a minimum of 26.6% to a maximum of 90.2%. These results suggest that tannic acid stably binds SCANDAL to the hair surface, which allows for its gradual release into the hair follicle, resulting in a hair loss alleviation effect. >
This study was conducted with the support of Polyphenol Factory, a KAIST faculty startup company.
2025.02.06 View 13194 -
KAIST Professor Uichin Lee Receives Distinguished Paper Award from ACM
< Photo. Professor Uichin Lee (left) receiving the award >
KAIST (President Kwang Hyung Lee) announced on the 25th of October that Professor Uichin Lee’s research team from the School of Computing received the Distinguished Paper Award at the International Joint Conference on Pervasive and Ubiquitous Computing and International Symposium on Wearable Computing (Ubicomp / ISWC) hosted by the Association for Computing Machinery (ACM) in Melbourne, Australia on October 8.
The ACM Ubiquitous Computing Conference is the most prestigious international conference where leading universities and global companies from around the world present the latest research results on ubiquitous computing and wearable technologies in the field of human-computer interaction (HCI).
The main conference program is composed of invited papers published in the Proceedings of the ACM (PACM) on Interactive, Mobile, Wearable and Ubiquitous Technologies (IMWUT), which covers the latest research in the field of ubiquitous and wearable computing.
The Distinguished Paper Award Selection Committee selected eight papers among 205 papers published in Vol. 7 of the ACM Proceedings (PACM IMWUT) that made outstanding and exemplary contributions to the research community. The committee consists of 16 prominent experts who are current and former members of the journal's editorial board which made the selection after a rigorous review of all papers for a period that stretched over a month.
< Figure 1. BeActive mobile app to promote physical activity to form active lifestyle habits >
The research that won the Distinguished Paper Award was conducted by Dr. Junyoung Park, a graduate of the KAIST Graduate School of Data Science, as the 1st author, and was titled “Understanding Disengagement in Just-in-Time Mobile Health Interventions”
Professor Uichin Lee’s research team explored user engagement of ‘Just-in-Time Mobile Health Interventions’ that actively provide interventions in opportune situations by utilizing sensor data collected from health management apps, based on the premise that these apps are aptly in use to ensure effectiveness.
< Figure 2. Traditional user-requested digital behavior change intervention (DBCI) delivery (Pull) vs. Automatic transmission (Push) for Just-in-Time (JIT) mobile DBCI using smartphone sensing technologies >
The research team conducted a systematic analysis of user disengagement or the decline in user engagement in digital behavior change interventions. They developed the BeActive system, an app that promotes physical activities designed to help forming active lifestyle habits, and systematically analyzed the effects of users’ self-control ability and boredom-proneness on compliance with behavioral interventions over time.
The results of an 8-week field trial revealed that even if just-in-time interventions are provided according to the user’s situation, it is impossible to avoid a decline in participation. However, for users with high self-control and low boredom tendency, the compliance with just-in-time interventions delivered through the app was significantly higher than that of users in other groups.
In particular, users with high boredom proneness easily got tired of the repeated push interventions, and their compliance with the app decreased more quickly than in other groups.
< Figure 3. Just-in-time Mobile Health Intervention: a demonstrative case of the BeActive system: When a user is identified to be sitting for more than 50 mins, an automatic push notification is sent to recommend a short active break to complete for reward points. >
Professor Uichin Lee explained, “As the first study on user engagement in digital therapeutics and wellness services utilizing mobile just-in-time health interventions, this research provides a foundation for exploring ways to empower user engagement.” He further added, “By leveraging large language models (LLMs) and comprehensive context-aware technologies, it will be possible to develop user-centered AI technologies that can significantly boost engagement."
< Figure 4. A conceptual illustration of user engagement in digital health apps. Engagement in digital health apps consists of (1) engagement in using digital health apps and (2) engagement in behavioral interventions provided by digital health apps, i.e., compliance with behavioral interventions. Repeated adherences to behavioral interventions recommended by digital health apps can help achieve the distal health goals. >
This study was conducted with the support of the 2021 Biomedical Technology Development Program and the 2022 Basic Research and Development Program of the National Research Foundation of Korea funded by the Ministry of Science and ICT.
< Figure 5. A conceptual illustration of user disengagement and engagement of digital behavior change intervention (DBCI) apps. In general, user engagement of digital health intervention apps consists of two components: engagement in digital health apps and engagement in behavioral interventions recommended by such apps (known as behavioral compliance or intervention adherence). The distinctive stages of user can be divided into adoption, abandonment, and attrition. >
< Figure 6. Trends of changes in frequency of app usage and adherence to behavioral intervention over 8 weeks, ● SC: Self-Control Ability (High-SC: user group with high self-control, Low-SC: user group with low self-control) ● BD: Boredom-Proneness (High-BD: user group with high boredom-proneness, Low-BD: user group with low boredom-proneness). The app usage frequencies were declined over time, but the adherence rates of those participants with High-SC and Low-BD were significantly higher than other groups. >
2024.10.25 View 17416 -
KAIST to showcase a pack of KAIST Start-ups at CES 2023
- KAIST is to run an Exclusive Booth at the Venetian Expo (Hall G) in Eureka Park, at CES 2023, to be held in Las Vegas from Thursday, January 5th through Sunday, the 8th.
- Twelve businesses recently put together by KAIST faculty, alumni, and the start-ups given legal usage of KAIST technologies will be showcased.
- Out of the participating start-ups, the products by Fluiz and Hills Robotics were selected as the “CES Innovation Award 2023 Honoree”, scoring top in their respective categories.
On January 3, KAIST announced that there will be a KAIST booth at Consumer Electronics Show (CES) 2023, the most influential tech event in the world, to be held in Las Vegas from January 3 to 8.
At this exclusive corner, KAIST will introduce the technologies of KAIST start-ups over the exhibition period.
KAIST first started holding its exclusive booth in CES 2019 with five start-up businesses, following up at CES 2020 with 12 start-ups and at CES 2022 with 10 start-ups. At CES 2023, which would be KAIST’s fourth conference, KAIST will be accompanying 12 businesses including start-ups by the faculty members, alumni, and technology transfer companies that just began their businesses with technologies from their research findings that stands a head above others.
To maximize the publicity opportunity, KAIST will support each company’s marketing strategies through cooperation with the Korea International Trade Association (KITA), and provide an opportunity for the school and each startup to create global identity and exhibit the excellence of their technologies at the convention.
The following companies will be at the KAIST Booth in Eureka Park:
The twelve startups mentioned above aim to achieve global technology commecialization in their respective fields of expertise spanning from eXtended Reality (XR) and gaming, to AI and robotics, vehicle and transport, mobile platform, smart city, autonomous driving, healthcare, internet of thing (IoT), through joint research and development, technology transfer and investment attraction from world’s leading institutions and enterprises.
In particular, Fluiz and Hills Robotics won the CES Innovation Award as 2023 Honorees and is expected to attain greater achievements in the future.
A staff member from the KAIST Institute of Technology Value Creation said, “The KAIST Showcase for CES 2023 has prepared a new pitching space for each of the companies for their own IR efforts, and we hope that KAIST startups will actively and effectively market their products and technologies while they are at the convention. We hope it will help them utilize their time here to establish their name in presence here which will eventually serve as a good foothold for them and their predecessors to further global commercialization goals.”
2023.01.04 View 28688 -
“3D sketch” Your Ideas and Bring Them to Life, Instantly!
Professor Seok-Hyung Bae’s research team at the Department of Industrial Design developed a novel 3D sketching system that rapidly creates animated 3D concepts through simple user interactions like sketching on a piece of paper or playing a toy.
Foldable drones, transforming vehicles, and multi-legged robots from sci-fi movies are now becoming commonplace thanks to technological progress. However, designing them remains a difficult challenge even for skilled experts, because complex design decisions must be made regarding not only their form, but also the structure, poses, and motions, which are interdependent on one another.
Creating a 3D concept comprising of multiple moving parts connected by different types of joints using a traditional 3D CAD tool, which is more suited for processing precise and elaborate modeling, is a painstaking and time-consuming process. This presents a major bottleneck for the workflow during the early stage of design, in which it is preferred that as many ideas are tried and discarded out as quickly as possible in order to explore a wide range of possibilities in the shortest amount of time.
A research team led by Professor Bae has focused on designers’ freehand sketches drew up with a pen on a paper that serve as the starting point for virtually all design projects. This led them to develop their 3D sketching technology to generate desired 3D curves from the rough but expressive 2D strokes drawn with a digital stylus on a digital tablet.
Their latest research helps designers bring their 3D sketches to life almost instantly. Using the intuitive set of multi-touch gestures the team successfully designed and implemented, designers can handle the 3D sketches they are working on with their fingers as if they are playing with toys and put them into animation in no time.
< Figure 1. A novel 3D sketching system for rapidly designing articulated 3D concepts with a small set of coherent pen and multi-touch gestures. (a) Sketching: A 3D sketch curve is created by marking a pen stroke that is projected onto a sketch plane widget. (b) Segmenting: Entire or partial sketch curves are added to separate parts that serve as links in the kinematic chain. (c) Rigging: Repeatedly demonstrating the desired motion of a part leaves behind a trail, from which the system infers a joint. (d) Posing: Desired poses can be achieved through actuating joints via forward or inverse kinematics. (e) Filming: A sequence of keyframes specifying desired poses and viewpoints is connected as a smooth motion. >
< Figure 2. (a) Concept drawing of an autonomous excavator. It features (b, c) four caterpillars that swivel for high maneuverability, (d) an extendable boom and a bucket connected by multiple links, and (e) a rotating platform. The concept’s designer, who had 8 years of work experience, estimated that it would take 1-2 weeks to express and communicate such a complex articulated object with existing tools. With the proposed system, it took only 2 hours and 52 minutes. >
The major findings of their work were published under the title “Rapid Design of Articulated Objects” in ACM Transactions on Graphics (impact factor: 7.403), the top international journal in the field of computer graphics, and presented at ACM SIGGRAPH 2022 (h5-index: 103), the world’s largest international academic conference in the field, which was held back in August in Vancouver, Canada with Joon Hyub Lee, a Ph.D. student of the Department of Industrial Design as the first author.
The ACM SIGGRAPH 2022 conference was reportedly attended by over 10,000 participants including researchers, artists, and developers from world-renowned universities; film, animation, and game studies, such as Marvel, Pixar, and Blizzard; high-tech manufacturers, such as Lockheed Martin and Boston Dynamics; and metaverse platform companies, such as Meta and Roblox.
< Figure 3. The findings of Professor Bae’s research team were published in ACM Transactions on Graphics, the top international academic journal in the field of computer graphics, and presented at ACM SIGGRAPH 2022, the largest international academic conference held in conjunction early August in Vancouver, Canada. The team’s live demo at the Emerging Technologies program was highly praised by numerous academics and industry officials and received an Honorable Mention. >
The team was also invited to present their technical paper as a demo and a special talk at the Emerging Technologies program at ACM SIGGRAPH 2022 as one of the top-three impactful technologies. The live performance, in which Hanbit Kim, a Ph.D. student of the Department of Industrial Design at KAIST and a co-author, sketched and animated a sophisticated animal-shaped robot from scratch in a matter of a few minutes, wowed the audience and won the Honorable Mention Award from the jury.
Edwin Catmull, the co-founder of Pixar and a keynote speaker at the SIGGRAPH conference, praised the team’s research on 3D sketching as “really excellent work” and “a kind of tool that would be useful to Pixar's creative model designers.”
This technology, which became virally popular in Japan after featuring in an online IT media outlet and attracting more than 600K views, received a special award from the Digital Content Association of Japan (DCAJ) and was invited and exhibited for three days at Tokyo in November, as a part of Inter BEE 2022, the largest broadcasting and media expo in Japan.
“The more we come to understand how designers think and work, the more effective design tools can be built around that understanding,” said Professor Bae, explaining that “the key is to integrate different algorithms into a harmonious system as intuitive interactions.” He added that “this work wouldn’t have been possible if it weren’t for the convergent research environment cultivated by the Department of Industrial Design at KAIST, in which all students see themselves not only as aspiring creative designers, but also as practical engineers.”
By enabling designers to produce highly expressive animated 3D concepts far more quickly and easily in comparison to using existing methods, this new tool is expected to revolutionize design practices and processes in the content creation, manufacturing, and metaverse-related industries.
This research was funded by the Ministry of Science and ICT, and the National Research Foundation of Korea.
More info: https://sketch.kaist.ac.kr/publications/2022_siggraph_rapid_design
Video: https://www.youtube.com/watch?v=rsBl0QvSDqI
< Figure 4. From left to right: Ph.D. students Hanbit Kim, and Joon Hyub Lee and Professor Bae of the Department of Industrial Design, KAIST >
2022.11.23 View 17703 -
KAIST Team Develops Surface-Lighting MicroLED Patch with Significant Melanogenesis Inhibition Effect
A KAIST research team led by Ph.d candidate Jae Hee Lee and Professor Keon Jae Lee from the Department of Materials Science and Engineering has developed a surface-lighting microLED patch for UV-induced melanogenesis inhibition.
Melanin is brown or dark pigments existing in the skin, which can be abnormally synthesized by external UV or stress. Since the excessive melanin leads to skin diseases such as spots and freckles, proper treatment is required to return normal skin condition.
Recently, LED-based photo-stimulators have been released for skin care, however, their therapeutic effect is still controversial. Since conventional LED stimulators cannot conformally attach to the human skin, distance-induced side effects are caused by light loss and high heat transfer. To achieve effective phototreatment, the LED stimulator needs to be irradiated in contact with the human skin surface, enabling proper and uniform light deliver to the dermis with minimal optical loss.
In this work, the research team fabricated skin-attachable surface-lighting microLED (SµLED, 4 × 4 cm2) patch by utilizing a thousand of microLED chips and silica-embedded light diffusion layer. 100 µm-sized LED chips are vertically-interconnected for high flexibility and low heat generation, allowing its long-term operation on the human skin.
< Image 1. The overall concept of SµLED patch. a) SµLED patch operated on the human skin. b) Schematic illustration of SµLED patch structure. c) 4 × 4 cm2-sized SµLED patch. d) Schematic illustration of the advantages of SµLED patch such as efficient light delivery, low heat generation, and surface-lighting irradiation. >
The research team confirmed melanogenesis inhibition by irradiating the SµLED patch and the conventional LED (CLED) on the artificial human skin and mice dorsal skin. The SµLED-treated groups of human cells and mouse tissues showed minimal epidermal photo-toxicity and consistently effective reduction in synthesized melanin, compared to CLED-treated groups. In addition, significant suppression of proteins/catalysts expression involved in melanin synthesis such as MITF (microphthalmia-associated transcription factor), Melan-A and tyrosinase was verified.
< Image 2. The efficacy of melanogenesis inhibition on 3D human skin cells. a). Different irradiation conditions for a-MSH (major factor to stimulate melanin synthesis) treated cells. b) The ratio of pigmented area to total epidermis area. c) Relative variance of melanin level in 1 cm2-sized skin cells. A low variance means that melanin is evenly distributed, and a high variance means that the melanin is irregularly distributed. d) Optical images after in vitro experiments for 12 days. Scale bar, 1cm. e) Histological analysis of 3D skin, showing the greatest reduction in melanin after SµLED irradiation. Scale bar, 20 µm. >
< Image 3. The efficacy of melanogenesis inhibition on mouse dorsal skin. a) Optical images of mice dorsal skin after photo-treatment for 20 days. b) Histological analysis of mice dorsal skin. Less brown color means less expression of protein/catalysis involved in melanin synthesis. Scale bar, 50 µm. >
Prof. Keon Jae Lee said, “Our inorganic-based SµLED patch has outstanding characteristics in light efficiency, reliability, and durability. The SµLED patch is expected to give a great impact on the cosmetic field by reducing side effects and maximizing phototherapeutic effects.” The core technology of cosmetic SµLED has been transferred to Fronics co., Ltd, founded by Prof. Lee. Fronics is building foundry and equipment for mass production of SµLED masks for whole face cover and plans to release the products in March next year.
This paper entitled “Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition” was published in the November 2022 issue of Advanced Healthcare Materials.
2022.11.22 View 19833 -
KAIST & LG U+ Team Up for Quantum Computing Solution for Ultra-Space 6G Satellite Networking
KAIST quantum computer scientists have optimized ultra-space 6G Low-Earth Orbit (LEO) satellite networking, finding the shortest path to transfer data from a city to another place via multi-satellite hops.
The research team led by Professor June-Koo Kevin Rhee and Professor Dongsu Han in partnership with LG U+ verified the possibility of ultra-performance and precision communication with satellite networks using D-Wave, the first commercialized quantum computer.
Satellite network optimization has remained challenging since the network needs to be reconfigured whenever satellites approach other satellites within the connection range in a three-dimensional space. Moreover, LEO satellites orbiting at 200~2000 km above the Earth change their positions dynamically, whereas Geo-Stationary Orbit (GSO) satellites do not change their positions. Thus, LEO satellite network optimization needs to be solved in real time.
The research groups formulated the problem as a Quadratic Unconstrained Binary Optimization (QUBO) problem and managed to solve the problem, incorporating the connectivity and link distance limits as the constraints.
The proposed optimization algorithm is reported to be much more efficient in terms of hop counts and path length than previously reported studies using classical solutions. These results verify that a satellite network can provide ultra-performance (over 1Gbps user-perceived speed), and ultra-precision (less than 5ms end-to-end latency) network services, which are comparable to terrestrial communication.
Once QUBO is applied, “ultra-space networking” is expected to be realized with 6G. Researchers said that an ultra-space network provides communication services for an object moving at up to 10 km altitude with an extreme speed (~ 1000 km/h). Optimized LEO satellite networks can provide 6G communication services to currently unavailable areas such as air flights and deserts.
Professor Rhee, who is also the CEO of Qunova Computing, noted, “Collaboration with LG U+ was meaningful as we were able to find an industrial application for a quantum computer. We look forward to more quantum application research on real problems such as in communications, drug and material discovery, logistics, and fintech industries.”
2022.06.17 View 15239