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The Dynamic Tracking of Tissue-Specific Secretory Proteins
Researchers develop a versatile and powerful tool for studying the spatiotemporal dynamics of secretory proteins, a valuable class of biomarkers and therapeutic targets Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. This method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1. Secretory proteins released into the blood play essential roles in physiological systems. They are core mediators of interorgan communication, while serving as biomarkers and therapeutic targets. Previous studies have analyzed conditioned media from culture models to identify cell type-specific secretory proteins, but these models often fail to fully recapitulate the intricacies of multi-organ systems and thus do not sufficiently reflect biological realities. These limitations provided compelling motivation for the research team led by Jae Myoung Suh and his collaborators to develop techniques that could identify and resolve characteristics of tissue-specific secretory proteins along time and space dimensions. For addressing this gap in the current methodology, the research team utilized proximity-labeling enzymes such as TurboID to label secretory proteins in endoplasmic reticulum lumen using biotin. Thereafter, the biotin-labeled secretory proteins were readily enriched through streptavidin affinity purification and could be identified through mass spectrometry. To demonstrate its functionality in live mice, research team delivered TurboID to mouse livers via an adenovirus. After administering the biotin, only liver-derived secretory proteins were successfully detected in the plasma of the mice. Interestingly, the pattern of biotin-labeled proteins secreted from the liver was clearly distinctive from those of hepatocyte cell lines. First author Kwang-eun Kim from the Graduate School of Medical Science and Engineering explained, “The proteins secreted by the liver were significantly different from the results of cell culture models. This data shows the limitations of cell culture models for secretory protein study, and this technique can overcome those limitations. It can be further used to discover biomarkers and therapeutic targets that can more fully reflect the physiological state.” This work research was supported by the National Research Foundation of Korea, the KAIST Key Research Institutes Project (Interdisciplinary Research Group), and the Institute for Basic Science in Korea. -PublicationKwang-eun Kim, Isaac Park et al., “Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice,” Nature Communications on Sept.1, 2021(https://doi.org/10.1038/s41467-021-25546-y) -ProfileProfessor Jae Myoung Suh Integrated Lab of Metabolism, Obesity and Diabetes Researchhttps://imodkaist.wixsite.com/home Graduate School of Medical Science and Engineering College of Life Science and BioengineeringKAIST
New Nanoparticle Drug Combination For Atherosclerosis
Physicochemical cargo-switching nanoparticles (CSNP) designed by KAIST can help significantly reduce cholesterol and macrophage foam cells in arteries, which are the two main triggers for atherosclerotic plaque and inflammation. The CSNP-based combination drug delivery therapy was proved to exert cholesterol-lowering, anti-inflammatory, and anti-proliferative functions of two common medications for treating and preventing atherosclerosis that are cyclodextrin and statin. Professor Ji-Ho Park and Dr. Heegon Kim from KAIST’s Department of Bio and Brain Engineering said their study has shown great potential for future applications with reduced side effects. Atherosclerosis is a chronic inflammatory vascular disease that is characterized by the accumulation of cholesterol and cholesterol-loaded macrophage foam cells in the intima. When this atherosclerotic plaque clogs and narrows the artery walls, they restrict blood flow and cause various cardiovascular conditions such as heart attacks and strokes. Heart attacks and strokes are the world’s first and fifth causes of death respectively. Oral statin administration has been used in clinics as a standard care for atherosclerosis, which is prescribed to lower blood cholesterol and inhibit its accumulation within the plaque. Although statins can effectively prevent the progression of plaque growth, they have only shown modest efficacy in eliminating the already-established plaque. Therefore, patients are required to take statin drugs for the rest of their lives and will always carry the risk of plaque ruptures that can trigger a blood clot. To address these issues, Professor Park and Dr. Kim exploited another antiatherogenic agent called cyclodextrin. In their paper published in the Journal of Controlled Release on March 10, Professor Park and Dr. Kim reported that the polymeric formulation of cyclodextrin with a diameter of approximately 10 nanometers(nm) can accumulate within the atherosclerotic plaque 14 times more and effectively reduce the plaque even at lower doses, compared to cyclodextrin in a non-polymer structure. Moreover, although cyclodextrin is known to have a cytotoxic effect on hair cells in the cochlea, which can lead to hearing loss, cyclodextrin polymers developed by Professor Park’s research group exhibited a varying biodistribution profile and did not have this side effect. In the follow-up study reported in ACS Nano on April 28, the researchers exploited both cyclodextrin and statin and form the cyclodextrin-statin self-assembly drug complex, based on previous findings that each drug can exert local anti-atherosclerosis effect within the plaque. The complex formation processes were optimized to obtain homogeneous and stable nanoparticles with a diameter of about 100 nm for systematic injection. The therapeutic synergy of cyclodextrin and statin could reportedly enhance plaque-targeted drug delivery and anti-inflammation. Cyclodextrin led to the regression of cholesterol in the established plaque, and the statins were shown to inhibit the proliferation of macrophage foam cells. The study suggested that combination therapy is required to resolve the complex inflammatory cholesterol-rich microenvironment within the plaque. Professor Park said, “While nanomedicine has been mainly developed for the treatment of cancers, our studies show that nanomedicine can also play a significant role in treating and preventing atherosclerosis, which causes various cardiovascular diseases that are the leading causes of death worldwide.” This work was supported by KAIST and the National Research Foundation (NRF) of Korea. Publications: 1. Heegon Kim, Junhee Han, and Ji-Ho Park. (2020) ‘Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity’ Journal of Controlled Release. Volume 319. Page 77-86. Available online at https://doi.org/10.1016/j.jconrel.2019.12.021 2. Kim, H., et al. (2020) ‘Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy’ ACS Nano. Available online at https://doi.org/10.1021/acsnano.9b08216 Profile: Ji-Ho Park, Ph.D. Associate Professor email@example.com http://openwetware.org/wiki/Park_Lab Biomaterials Engineering Laboratory (BEL) Department of Bio and Brain Engineering (BIOENG) Korea Advanced Institute of Science and Technology (KAIST) https://www.kaist.ac.kr Daejeon 34141, Korea Profile: Heegon Kim, Ph.D. Postdoctoral Researcher firstname.lastname@example.org BEL, BIOENG, KAIST (END)
Deep Learning-Powered 'DeepEC' Helps Accurately Understand Enzyme Functions
(Figure: Overall scheme of DeepEC) A deep learning-powered computational framework, ‘DeepEC,’ will allow the high-quality and high-throughput prediction of enzyme commission numbers, which is essential for the accurate understanding of enzyme functions. A team of Dr. Jae Yong Ryu, Professor Hyun Uk Kim, and Distinguished Professor Sang Yup Lee at KAIST reported the computational framework powered by deep learning that predicts enzyme commission (EC) numbers with high precision in a high-throughput manner. DeepEC takes a protein sequence as an input and accurately predicts EC numbers as an output. Enzymes are proteins that catalyze biochemical reactions and EC numbers consisting of four level numbers (i.e., a.b.c.d) indicate biochemical reactions. Thus, the identification of EC numbers is critical for accurately understanding enzyme functions and metabolism. EC numbers are usually given to a protein sequence encoding an enzyme during a genome annotation procedure. Because of the importance of EC numbers, several EC number prediction tools have been developed, but they have room for further improvement with respect to computation time, precision, coverage, and the total size of the files needed for the EC number prediction. DeepEC uses three convolutional neural networks (CNNs) as a major engine for the prediction of EC numbers, and also implements homology analysis for EC numbers if the three CNNs do not produce reliable EC numbers for a given protein sequence. DeepEC was developed by using a gold standard dataset covering 1,388,606 protein sequences and 4,669 EC numbers. In particular, benchmarking studies of DeepEC and five other representative EC number prediction tools showed that DeepEC made the most precise and fastest predictions for EC numbers. DeepEC also required the smallest disk space for implementation, which makes it an ideal third-party software component. Furthermore, DeepEC was the most sensitive in detecting enzymatic function loss as a result of mutations in domains/binding site residue of protein sequences; in this comparative analysis, all the domains or binding site residue were substituted with L-alanine residue in order to remove the protein function, which is known as the L-alanine scanning method. This study was published online in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) on June 20, 2019, entitled “Deep learning enables high-quality and high-throughput prediction of enzyme commission numbers.” “DeepEC can be used as an independent tool and also as a third-party software component in combination with other computational platforms that examine metabolic reactions. DeepEC is freely available online,” said Professor Kim. Distinguished Professor Lee said, “With DeepEC, it has become possible to process ever-increasing volumes of protein sequence data more efficiently and more accurately.” This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT through the National Research Foundation of Korea. This work was also funded by the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korean government, the Ministry of Science and ICT. Profile: -Professor Hyun Uk Kim (email@example.com) https://sites.google.com/view/ehukim Department of Chemical and Biomolecular Engineering -Distinguished Professor Sang Yup Lee (firstname.lastname@example.org) Department of Chemical and Biomolecular Engineering http://mbel.kaist.ac.kr
In Jin Cho Earned the Best Poster Prize at ME Summit 2017
In Jin Cho, a Ph.D. student in the Department of Chemical and Biomolecular Engineering at KAIST received the best poster prize at the International Metabolic Engineering Summit 2017 held on October 24 in Beijing, China. The International Metabolic Engineering Summit is a global conference where scientists and corporate researchers in the field of metabolic engineering present their latest research outcomes and build networks. At this year’s summit, about 500 researchers from around the world participated in active academic exchanges, including giving keynote speeches and presenting posters. During the poster session, the summit selects one person for the KeAi-synthetic and Systems Biotechnology Poster Award, two for Microbial Cell Factories Poster Awards, and three for Biotechnology Journal Poster Awards among the posters presented by graduate students, post-doctoral fellows and researchers. Cho received the KeAi-synthetic and Systems Biotechnology Poster Award. Her winning poster is on the biotransformation of p-xylene to terephthalic acid using engineered Escherichia coli. Terephthalic acid is generally produced by p-xylene oxidation; however, this process requires a high temperature and pressure as well as a toxic catalyst during the reaction process. Cho and Ziwei Luo, a Ph.D. student at KAIST, co-conducted the research and developed a successful biological conversion process. Compared to the existing chemical process, it does not require a high temperature and pressure; and it is environmentally friendly with a relatively high conversion rate of approximately 97%. Cho’s advisor, Distinguished Professor Sang Yup Lee said, “Further research on glucose-derived terephthalic acid will enable us to produce biomass-based eco-friendly terephthalic acid through engineered Escherichia coli.”
Professor Jae Kyoung Kim Receives the 2017 HSFP Award
The Human Frontier Science Program (HSFP), one of the most competitive research grants in life sciences, has funded researchers worldwide across and beyond the field since 1990. Each year, the program selects a handful of recipients who push the envelope of basic research in biology to bring breakthroughs from novel approaches. Among its 7,000 recipients thus far, 26 scientists have received the Nobel Prize. For that reason, HSFP grants are often referred to as “Nobel Prize Grants.” Professor Jae Kyoung Kim of the Mathematical Sciences Department at KAIST and his international collaborators, Professor Robert Havekes from the University of Groningen, the Netherlands, Professor Sara Aton from the University of Michigan in Ann Arbor, the United States, and Professor Matias Zurbriggen from the University of Düsseldorf, Germany, won the Young Investigator Grants of the 2017 HSFP. The 30 winning teams of the 2017 competition (in 9 Young Investigator Grants and 21 Program Grants) went through a rigorous year-long review process from a total of 1,073 applications submitted from more than 60 countries around the world. Each winning team will receive financial support averaging 110,000-125,000 USD per year for three years. Although Professor Kim was trained as a mathematician, he has extended his research focus into biological sciences and attempted to solve some of the most difficult problems in biology by employing mathematical theories and applications including nonlinear dynamics, stochastic process, singular perturbation, and parameter estimation. The project that won the Young Investigator Grants was a study on how a molecular circadian clock may affect sleep-regulated neurophysiology in mammals. Physiological and metabolic processes such as sleep, blood pressure, and hormone secretion exhibit circadian rhythms in mammals. Professor Kim used mathematical modeling and analysis to explain that the mammalian circadian clock is a hierarchical system, in which the master clock in the superchiasmatic nucleus, a tiny region in the brain that controls circadian rhythms, functions as a pacemaker and synchronizer of peripheral clocks to generate coherent systematic rhythms throughout the body. Professor Kim said, “The mechanisms of our neuronal and hormonal activities regulating many of our bodily functions over a 24-hour cycle are not yet fully known. We go to sleep every night, but do not really know how it affects our brain functions. I hope my experience in mathematics, along with insights from biologists, can find meaningful answers to some of today’s puzzling problems in biological sciences, for example, revealing the complexities of our brains and showing how they work.” “In the meantime, I hope collaborations between the fields of mathematics and biology, as yet a rare phenomenon in the Korean scientific community, will become more popular in the near future.” Professor Kim received his doctoral degree in Applied and Interdisciplinary Mathematics in 2013 from the University of Michigan and joined KAIST in 2015. He has published numerous articles in reputable science journals such as Science, Molecular Cell, Proceedings of the National Academy of Sciences, and Nature Communications. Both the Program Grants and Young Investigator Grants support international teams with members from at least two countries for innovative and creative research. This year, the Program Grants were awarded to research topics ranging from the evolution of counting and the role of extracellular vesicles in breast cancer bone metastasis to the examination of obesity from a mechanobiological point of view. The Young Investigator Grants are limited to teams that established their independent research within the last five years and received their doctoral degrees within the last decade. Besides Professor Kim’s study, such topics as the use of infrasound for navigation by seabirds and protein formation in photochemistry and photophysics were awarded in 2017. Full lists of the 2017 HFSP winners are available at: http://www.hfsp.org/awardees/newly-awarded. About the Human Frontier Science Program (HFSP): The HFSP is a research funding program implemented by the International Human Frontier Science Program (HFSPO) based in Strasbourg, France. It promotes intercontinental collaboration and training in cutting-edge, interdisciplinary research specializing in life sciences. Founded in 1989, the HFSPO consists of the European Union and 14 other countries including the G7 nations and South Korea.
Nobel Laureate Dr. John Michael Kosterlitz Speaks at KAIST
KAIST’s Department of Physics will invite one of three co-recipients of the Nobel Prize in Physics 2016, Professor John Michael Kosterlitz of Brown University, on January 9, 2017, to speak about the exotic states of matter, which is entitled “Topological Defects and Phase Transitions.” Professor Kosterlitz shares the Nobel award with two other researchers, David Thouless and Duncan Haldane. He is considered one of the pioneers in the field of topological phases. In the early 1970s, along with Thouless, he demonstrated that superconductivity could occur at low temperatures and explained the mechanism behind, phase transition, that makes superconductivity disappear at higher temperatures. Over the last decade, topological materials and their applications have been widely studied with the hope of using them in new generations of electronics and superconductors, or in future quantum computers. Details of the lecture follow below: Distinguished Lecture Series by KAIST’s Physics Department · Speaker: Professor John Michael Kosterlitz of the Physics Department, Brown University · Topic: “Topological Defects and Phase Transitions” · Date: January 9, 2017, 4:00 PM · Place: Lecture Hall (#1501), College of Natural Sciences (E6-2)
Visit by Sir Paul Maxime Nurse, President of the Royal Society
Sir Paul Maxime Nurse, who is an English geneticist and cell biologist, visited KAIST and gave a lecture entitled The Great Ideas of Biology on March 11, 2014. Sir Paul was awarded the 2001 Nobel Prize in Physiology or Medicine with Leland H. Hartwell and R. Timothy Hunt for their discoveries of protein molecules that control the division of cells in the cell cycle. He was Professor of Microbiology at the University of Oxford, CEO of the Imperial Cancer Research Fund and Cancer Research UK, and President of Rockefeller University in New York. Sir Paul is currently the President of the Royal Society as well as Director and Chief Executive of the Francis Crick Institute. Founded in London in 1660, the Royal Society is composed of the world’s most distinguished scientists drawn from all areas of science, engineering, and medicine. Below is a summary of his lecture, The Great Ideas of Biology: Four major ideas of biology are the theory of genes, evolution by natural selection, the proposal that the cell is the fundamental unit of all life, and the chemical composition of a cell. When considering the question “what is life?” these ideas come together. The special way cells reproduce provides the conditions by which natural selection takes place, allowing living organisms to evolve. The organization of chemistry within the cell provides explanations for life’s phenomena. In addition, an emerging idea is the nature of biological self-organization with which living cells and organisms process information and acquire specific forms. These great ideas have influenced one another and changed the way we perceive biology and science today.
Short Wavelength, Ultra-High Speed Quantum Light Source based on Quantum Dot Developed
Professor Yong Hoon, Cho (Department of Physics) and his research team synthesized an obelisk nanostructure and successfully formed a single semiconductor quantum exhibiting high reliability to realize an ultra-high speed, highly efficient, release of quantum dots. The result of the research effort was published in the July 5th online edition of Scientific Reports published by Nature. Semiconductor Quantum Dots restrict electrons within a cubic boundary of few nanometers thereby exhibiting similar properties to an atom with discontinuous energy levels. Exploitation of this characteristic makes possible the development of quantum light source, critical for next generation quantum information communication and quantum encryption. High operational temperatures, stability, rapid photon release, electric current capability, and other advantages are reasons why semiconductor quantum dots are regarded as next generation core technology. However conventional, spontaneously formed quantum dots are densely packed in a planar structure rendering the analysis of a single quantum dot difficult and result in the poor efficiency of photon release. In addition, the internal electromagnetic effect which is caused by inter-planar stress results in low internal quantum efficiency due to the difficulty in electron-hole recombination. Professor Cho’s research team synthesized an obelisk shaped nanostructure using nitrides that emit short wavelengths of light. The activation layer was grown on the tip of the nanostructure and the team succeeded in placing a single quantum dot on the nano-tip. The team was therefore able to confirm the ultra-high speed single photon characteristics which occur at low energy levels. Use of unique nanostructures makes synthesis of single atomic structures without processes like patterning while enabling the release of light emitted by the quantum dot. Using this unique method the team showed the increase in internal quantum efficiency. The electromagnetic forces apparent in thin films no longer affects the quantum dot greatly due to the obelisk structure’s reduced inter planar stress. The newly developed quantum light source emits visible light (400nm range) and not the conventional infrared light. This characteristic makes possible it use in communication in free space and enables use of highly efficient, visible range photon detector. Professor Cho commented that “the developed method makes quantum dot growth much easier making single photon synthesis much faster to contribute to the development of practical quantum light source.” And that “the characteristics of the obelisk nanostructure enable the easy detachment from and attachment to other substrates enabling its use in producing single chip quantum light source.” The research was conducted under the supervision of Professor Cho. The researchers werey Jae Hyung, Kim (first author) and Yong Ho, Ko (second author), both Ph.D. candidates at KAIST. The Ministry of Science, ICT and Future Planning, the National Research Foundation, and WCU Program provided support to the research effort.
New Structural Insight into Neurodegenerative Disease
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. Mutations in Ataxin-1 cause the neurological disease, Spinocerebella Ataxia Type 1 (SCA1), which is characterized by a loss of muscular coordination and balance (ataxia), as is seen in Parkinson’s, Alzheimer’s, and Huntington’s diseases. SCA1-causing mutations in the ATAXIN1 gene alter the length of a glutamine stretch in the Ataxin-1 protein. The research team provides the first structural insight into the complex formation of ATAXIN-1 with its binding partner, Capicua (CIC). The team, led by Professor Ji-Joon Song from the Department of Biological Sciences at KAIST, solved the structure of Ataxin-1 and CIC complex in atomic level revealing molecular details of the interaction between Ataxin-1 and CIC. Professor Song explained his recent research work, “We are able to see the intricate process of complex formation and reconfiguration of the two proteins when they interact with each other. Our work, we expect, will provide a new therapeutic target to modulate SCA1 neurodegenerative disease.” Understanding structural and molecular details of proteins at the atomic level will help researchers to track the molecular pathogenesis of the disease and, ultimately, design targeted therapies or treatments for patients, rather than just relieving the symptoms of diseases. Professor Song’s research paper, entitled “Structural Basis of Protein Complex Formation and Reconfiguration by Polyglutamine Disease Protein ATAXIN-1 and Capicua,” will be published in the March 15th issue of Genes & Development (www.genesdev.org). Complex Formation and Reconfiguration of ATAXIN-1 and Capicua The complex formation between a polyglutamine disease protein, ATXIN-1 and the transcriptional repressor Capicua (CIC) plays a critical role in SCA 1 pathogenesis. The image shows that the homodimerization of ATXIN-1 (yellow and red) is disrupted upon binding of CIC (blue). Furthermore, the binding of CIC to the ATXIN-1 induces a new form of ATXIN-1 dimerization mediated by CICs (ATXIN-1 AXH domains are shown in yellow and red, and CIC peptides shown in blue and white).
The 6th president of KAIST passed away on May 7, 2010.
Dr. Sang-Soo Lee was the first president of Korea Advanced Institute of Science (KAIS) and the 6th president of KAIST, who died of a chronic disease at the age of 85. The KAIS was the matrix of KAIST today. Graduated from the physics department of Seoul National University in 1949, he later received a doctoral degree in optics from Imperial College of Science and Technology, University of London. Dr. Lee has greatly contributed to the development of science and technology in Korea in the capacity of a policy administrator, educator, scientist, researcher, and engineer. He held numerous prestigious offices including President of Korea Atomic Energy Research Institute in 1967, of KAIS in 172, and of KAIST in 1989. Dr. Lee also worked as a professor at the physics department of KAIST for 20 years from 1972-1992. The Society of Photographic Instrumentation Engineers (SPIE), an international society for optics and photonics, was founded in 1955 to advance light-based technologies. Dr. Sang-Soo Lee was a member of the SPIE that issued a news release expressing its sincere condolences to his death. The following is the full text of the news release: http://spie.org/x40527.xml In memoriam: Sang Soo Lee 10 May 2010 Sang Soo Lee, known as the "Father of Optics" in Korea passed away on May 7, 2010, in Korea. He was 84. Lee received a B.S. in Physics from Seoul National University in Korea and a Ph.D. from Imperial College of Science and Technology, University of London, UK. Receiving the first Ph.D. in Optics in Korea, Dr. Lee devoted his life to lay the foundation for optical science and engineering for more than four decades as an educator, researcher, and administrator in science policy. "He was one of the architects of the extraordinary and rapid emergence of Korea as a world leader in science and technology, or perhaps with the rich history of contributions centuries ago, re-emergence would be more appropriate." said Eugene G. Arthurs, SPIE Executive Director. During his teaching career, Dr. Lee mentored 50 doctoral and more than 100 masters" degree candidates. in the areas of laser physics, wave optics, and quantum optics. Many of his former students have become leaders in academia, government-funded research institutes, and industry both in Korea and abroad. He published more than 250 technical papers and authored five textbooks, including "Wave Optics", "Geometrical Optics", "Quantum Optics", and "Laser Speckles and Holography". Lee was the first president of the Korea Advanced Institute of Science and Technology (KAIST), and the first president to establish a new government funded graduate school. He played a pivotal role in founding the Optical Society of Korea (OSK) in 1989 and served as its first president. Lee was an active member of the international scientific community. In addition to his pioneering scholastic achievements at KAIST, he served as the Vice President of the International Commission for Optics (ICO), a Council Member of the Third World Academy of Sciences, and a Council Member of UN University, serving as an ambassador for the optics community, which showed a significant example of how a developing country like Korea can serve international optics community. Dr. Lee was a Fellow of the International Society for Optical Engineering (SPIE), the Optical Society of America (OSA), and the Korean Physical Society (KPS). He was the recipient of many awards and honors, including the National Order of Civil Merit that is the Presidential Medal of Honor from the Republic of Korea (2000), the Songgok Academic Achievement Prize, the Presidential Award for Science, and the Medal of Honor for Distinguished Scientific Achievement in Korea. In 2006, he was awarded OSA"s Esther Hoffman Beller Medal.
Int'l Telematic Music Concert for Peace to Take Place on Nov. 20
Renowned musicians in five international locations perform new contemporary music works for peace through a real-time performance on the internet. Local audiences in Seoul, Banff, New York, San Diego and Belfast will also have a chance to hear a program. In Seoul, the "International Telematic Music Concert for Peace" will be held at the LeeHaeRang Art Theater, Dongguk University, in Seoul on Nov. 20 at 9:30 a.m., under the presentation of KAIST"s Graduate School of Culture Technology and MARTE Lab, Dongguk University. Telematic music is real-time performance via the internet by musicians in different geographic locations. The program of the concert includes "Hope"s Dream" by Mark Dresser and Sarah Weaver; "Disparate Bodies" by Pedro Rebelo, "Rock, Paper, Scissors" by Chris Chafe. The Korean act to be performed is "Green-colored Harmony" by Jun Kim. In addition to the two Korean universities, the World Association of Former United Nations Internes and Fellows (WAFUNIF), University of California San Diego, the Banff Center of Canada and Queen"s University in Belfast are participating in the project. The performance will take place on high-bandwidth internet with JackTrip audio software developed by Chris Chafe and Access Grid video software developed at Argonne National Laboratory. "Connecting the five different cities together through super-speed Internet network and transmitting sound and images in real time is challenging technically. But, we also expect that more exciting results will be created in the course of transforming the sound into visual images," said Woon-Seung Yeo, a professor of the Graduate School of Culture Technology, who was responsible for visuals in the project.
U.S. Nobel Laureate to Run Korea's Top Tech University
Robert Laughlin, President of the Korea Advanced Institute of Science and Technology (KAIST) DAEJEON, July 14 (Yonhap) -- Nobel Physics Prize laureate Robert Laughlin was sworn in Wednesday as the first foreign president of the Korea Advanced Institute of Science and Technology (KAIST), South Korea"s top technology university. Laughlin, in his inauguration speech, pledged to transform the state-run Korean university into a globally competitive educational institution, while also vowing to make it research oriented. "Many people have asked me how I, as a foreigner, could possibly understand the situation here at KAIST, much less figure out a path forward," he said. "The short answer is that the situation here is not unique. The problems facing the research university are historical in nature and essentially identical all over the world." He added the same worried discussions are taking place in other universities around the globe such as at Stanford, the Massachusetts Institute of Technology, Heidelberg and Tokyo. "I have come here not to solve your problems but to solve my own," the 54-year-old American said. Laughlin said KAIST is a large, well-functioning organization for which few things needed to be changed. The former Stanford University professor also promised to work hard to lead the university in a novel direction. "All of us in the technical university have a holy obligation ... we are here for the sole purpose of having big dreams and finding the strength to make them come to pass," Laughlin said. "As far as I"m concerned, my job comes down to one thing: to make sure that your dreams are big enough, and to help everyone here -- faculty and students -- find the means to make them come to pass. That"s all," he said. The ceremony was attended by Science and Technology Minister Oh Myung, Daejeon City Mayor Yeom Hong-chul and U.S. Ambassador to South Korea Thomas Hubbard, among others. On Thursday, Laughlin is scheduled to meet President Roh Moo-hyun in Seoul. Laughlin will start his four-year term from mid-August, KAIST said. Laughlin won the Nobel Prize for Physics in 1998 with Horst Stoermer of Germany and Daniel Tsui of the United States for discovering a new form of quantum fluid that gives more profound insights into the general inner structure and dynamics of matter. On May 28, he was chosen to run the Korean university at a board meeting. (END)
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