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Unraveling the Secret of Cell Movement
<(From left) Professor Won Do Heo (KAIST), Postdoctoral Researcher Heeyoung Lee (KAIST, First Author), Professor Kwang-Hyun Cho (KAIST), Professor Kapsang Lee (Johns Hopkins University, USA), Dr. Sangkyu Lee (IBS), Dr. Dongsan Kim (LIBD), Dr. Yeaji Seo (Hulux) (Co-First Authors)>
Cell movement is an essential biological process, whether it's cancer cells metastasizing to other parts of the body or immune cells migrating to heal a wound. However, the principle by which cells autonomously determine their direction of movement without external stimuli has remained unknown until now.
Through this research, KAIST and an international joint research team have elucidated the principle by which cells decide their direction and move on their own, offering a crucial clue for identifying the causes of cancer metastasis and immune diseases and establishing new treatment strategies.
KAIST announced on the 10th of November that the research team led by Endowed Chair Professor Won Do Heo of the Department of Biological Sciences, in collaboration with the research team of Endowed Chair Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, and Professor Kapsang Lee's research team at Johns Hopkins University in the US, has for the first time in the world identified the 'autonomous driving mechanism' by which cells determine their direction of movement without external signals.
The research team developed a new imaging technique called 'INSPECT (INtracellular Separation of Protein Engineered Condensation Technique)' that allows direct visualization of how proteins interact within living cells. Using this technology, they revealed the principle of the cell's internal program for autonomously deciding its direction of movement.
The team newly analyzed the operation of the key proteins that regulate cell movement, the Rho family proteins (Rac1, Cdc42, RhoA). The results showed that these proteins do not merely divide the front and back of the cell, as previously theorized, but that the cell's decision to move straight or change direction depends on which protein it binds with.
The INSPECT technology artificially implements the phenomenon of 'phase separation,' where proteins, upon binding, naturally form segregated regions that do not mix well. This technique allows for the direct visualization of how proteins actually bind within the cell using a fluorescent signal.
<Figure 1. INSPECT: A technique for visualizing Intracellular Protein-Protein Interactions">
The research team used the proteins ferritin and the fluorescent protein DsRed to make the clusters, or 'condensates,' visible to the eye when proteins bind together like small droplets.
Using this technology, the team analyzed a total of 285 pairs of interactions by combining 15 types of Rho proteins with 19 types of binding proteins, confirming actual binding in 139 pairs. Specifically, they identified that the Cdc42–FMNL protein combination is the core circuit responsible for the cell's 'straight movement,' while the Rac1–ROCK protein combination is responsible for the cell's 'change of direction.'
The research team slightly modified a part of the Rac1 protein (the 37th amino acid), which is crucial for cell direction control, to prevent it from binding well with the 'steering wheel' protein, ROCK. As a result, the cells could not change direction and continued to move in a straight line.
In contrast, in normal cells, Rac1 and ROCK bind well, forming a structure called 'arc stress fiber' at the front of the cell. This fiber enables the cell to make near-perpendicular turns when changing direction.
Furthermore, in an experiment where the environment the cells were attached to was changed, normal cells adjusted their moving speed according to the surrounding environment, but the Rac1F37W cells (cells with a broken 'steering wheel') maintained the same speed regardless of environmental changes. This demonstrates that the Rac–ROCK protein axis subtly controls the cell's ability to recognize and adapt to its surrounding environment.
<Figure 2. Analysis of the Signaling Network through Screening of Protein Interactions that Bind to a Cell Migration-Controlling Protein>
Professor Won Do Heo stated, "This research reveals that cell movement is not a random motion but is precisely controlled by an intrinsic program created by the ensemble of Rho signaling proteins and cell migration-related proteins." He added, "The newly developed INSPECT technology is a powerful tool for visualizing intracellular protein interactions and will be broadly utilized to uncover the molecular mechanisms of various life phenomena and diseases, such as cancer metastasis and neuronal cell migration."
This research, in which Dr. Heeyoung Lee of KAIST, Dr. Sangkyu Lee (currently at IBS), Dr. Yeji Seo (currently at Hulux Co., Ltd.), and Dr. Dongsan Kim (currently at LIBD) participated as co-first authors, was published in Nature Communications on October 31st.
Journal Name: A Rho GTPase-effector ensemble governs cell migration behavior
DOI: https://doi.org/10.1038/s41467-025-64635-0
The research was supported by the Samsung Future Technology Foundation and the National Research Foundation of Korea.
2025.11.10 View 935 -
2017 ICISTS Conference 'Draw the Web: Interactions in Society'
The KAIST undergraduate organization, ICISTS (International Conference for Integration of Science, Technology and Society) will convene its annual conference from July 31 to Aug. 4 at the KAIST Daejeon Campus. This year’s theme is “Draw the Web: Interactions in Society.” More than 300 participants from 60 universities in 20 countries will participate in the international conference hosted and planned by the student organization.
Speakers at the 2017 conference include leaders in technology, business, investment, and entrepreneurship, and many others highlighted by Christoffer O. Hernæs, chief digital officer of Skandiabanken and vice president of strategy and innovation at Sparebank; Vincent C. Müller, professor of the philosophy division of humanities & social sciences at Anatolia College; Nigel Parker, director of developer and platform evangelism at Microsoft APAC; and Jon Gosier, founder and CEO of WoundedMetrics, who was voted as one of the 25 most influential African-Americans in technology by Business Insider in 2013 and 2014.
ICISTS has organized and hosted this event, the largest academic conference hosted and organized by students in Asia, since 2005 as a way to discuss an incredibly challenging issue: how science and technology is being integrated into society. This year’s conference will explore how prominent technological advancements are integrated, and how the interactions between humanity and technology will affect society. This year’s sub-theme is “Settlement, Movement, and Inequality.”
In addition to the main session, ICISTS is preparing discussion sessions in which guest speakers and participants will divide into small groups to discuss their responses to the themes. Various additional events including a culture night and an excursion program will serve as opportunities to network with other participants. For more information on the program and how to register, please visit http://www.icist.org.
2017.05.22 View 12175 -
Ph.D. Candidate Seo Wins the Human Tech Paper Award
Hyun-Suk Seo, a doctoral student of KAIST’s Department of Electrical Engineering, received the grand prize of the “22nd Human Tech Paper Award” on February 3, 2016 from Samsung Electronics Co., Ltd.
Seo was the first to receive this prize ever since the Human Tech Paper Award was established 22 years ago. Until last year, the highest prize awarded for KAIST was a gold one.
The “Human Tech Paper Award” was established in 1994 by Samsung Electronics to discover and support outstanding scientists in the field of electrical engineering.
Entitled “Self-Gated Cardiac Cine MRI Using Phase Information,” Seo’s paper presented a technology that would reduce discomforts and inconveniences experienced by patients who take a magnetic resonance imaging (MRI).
This technology uses the speed changes of aorta and the abdominal movements of body to obtain the phase changes of magnetic resonance signals so that MRIs may be taken despite the organs’ movements.
Seo commented on his research, “I wanted to develop a technique that can make MRI a more comfortable experience. I will continue my research on this subject and hope to serve the needs of the society.”
In addition, the “Special Award,” which is given to schools, was awarded to KAIST. KAIST’s Department of Electrical Engineering has also been named the department that has received the second most awards (15 awards) this year.
Oh-Hyun Kwon, Vice President of Samsung Electronics, Steve Kang, President of KAIST, and Nak-In Seo, President of Seoul National University, participated in the event.
Picture: Hyun-Suk Seo (left), the recipient of the grand prize of the 2016 Human Tech Paper Award, and Oh-Hyun Kwon (right), Vice President of Samsung Electronics
2016.02.06 View 14028 -
A KAIST student earns 500 million won with "Virtual Finger" idea.
A student’s small idea was transformed into a viable technology, yielding 500 million won through the technology transfer.
In a mobile environment, it is difficult to hold the device and use its multi touch function, at the same time. A doctorate candidate of the KAIST Cultural Technology Graduate School, Hwang Sung Jae (28 years old), identified the inconvenience that it is hard to see the full screen of a mobile phone while manipulating it, and he invented a helper called “Virtual Thumb.”
The thumb allows a user to use only one finger to perform tasks that require the movements of several fingers like punching, zooming in/out and rotating the screen. When the user touches a screen, a virtual finger is created on the other side of the screen and mimics the motion of the user’s touching.
The ‘virtual Finger’ technology is based on the idea that came in second in the 2009 Korea Invention Patent Competition hosted by the Korea Intellectual Property Office and can be applied to any device that has a touch-based system which spans from a TV remote controller to a Tablet PC’s.
The Office of University and Industry Cooperation, KAIST, facilitated to turn Hwang’s idea into commercialization, and on October 18, Victronix, a Korean mobile phone manufacturer, bought a patent right for the technology at 500 million won.
2010.12.13 View 12812 -
The KAIST & GIT team developed a power generation technology using bendable thin film nano-materials.
Figure description: Flexible thin film nanomaterials produce electricity.
Can a heart implanted micro robot operate permanently?
Can cell phones and tiny robots implanted in the heart operate permanently without having their batteries charged?
It might sound like science fiction, but these things seem to be possible in the near future. The team of Prof. Keon Jae Lee (KAIST, Dept. of Materials Science and Engineering) and Prof. Zhong Lin Wang (Georgia Institute of Technology, Dept. of Materials Science and Engineering) has developed new forms of highly efficient, flexible nanogenerator technology using the freely bendable piezoelectric ceramic thin film nano-materials that can convert tiny movements of the human body (such as heart beats and blood flow) into electrical energy.
The piezoelectric effect refers to voltage generation when pressure or bending strength is applied to piezoelectric materials. The ceramics, containing a perovskite structure, have a high piezoelectric efficiency. Until now, it has been very difficult to use these ceramic materials to fabricate flexible electronic systems due to their brittle property.
The research team, however, has succeeded in developing a bio-eco-friendly ceramic thin film nanogenerator that is freely bendable without breakdown.
Nanogenerator technology, a power generating system without wires or batteries, combines nanotechnology with piezoelectrics that can be used not only in personal mobile electronics but also in bio-implantable sensors or as an energy source for micro robots. Energy sources in nature (wind, vibration, and sound) and biomechanical forces produced by the human body (heart beats, blood flow, and muscle contraction/relaxation) can infinitely produce nonpolluting energy. (Nanogenerator produces electricity by external forces: http://www.youtube.com/watch?v=tvj0SsBqpBw)
Prof. Keon Jae Lee (KAIST) was involved in the first co-invention of “High Performance Flexible Single Crystal Electronics” during his PhD course at the University of Illinois at Urbana-Champaign. This nanogenerator technology, based on the previous invention, utilized the similar protocol of transferring ceramic thin film nano-materials on flexible substrates and produced voltage generation between electrodes.
Prof. Zhong Lin Wang (Georgia Tech, inventor of the nanogenerator) said, “This technology can be used to turn on an LED by slightly modifying circuits and operate touchable flexible displays. In addition, thin film nano-materials (‘barium titanate’) of this research have the property of both high efficiency and lead-free bio compatibility, which can be used in future medical applications.” This result is published in November online issue of ‘Nano Letters’ ACS journal.
<Video>
Youtube link: http://www.youtube.com/watch?v=tvj0SsBqpBw
Thin Film Nanogenerator produces electricity by external forces.
2010.11.23 View 21155