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Taesik Gong Named Google PhD Fellow
PhD candidate Taesik Gong from the School of Computing was named a 2020 Google PhD Fellow in the field of machine learning. The Google PhD Fellowship Program has recognized and supported outstanding graduate students in computer science and related fields since 2009. Gong is one of two Korean students chosen as the recipients of Google Fellowships this year. A total of 53 students across the world in 12 fields were awarded this fellowship. Gong’s research on condition-independent mobile sensing powered by machine learning earned him this year’s fellowship. He has published and presented his work through many conferences including ACM SenSys and ACM UbiComp, and has worked at Microsoft Research Asia and Nokia Bell Labs as a research intern. Gong was also the winner of the NAVER PhD Fellowship Award in 2018. (END)
Professor Jungwon Kim Named Scientist of October
Professor Jungwon Kim from the Department of Mechanical Engineering was selected as the ‘Scientist of the Month’ for October 2020 by the Ministry of Science and ICT and the National Research Foundation of Korea. Professor Kim was recognized for his contributions to expanding the horizons of the basics of precision engineering through his research on multifunctional ultrahigh-speed, high-resolution sensors. He received 10 million KRW in prize money. Professor Kim was selected as the recipient of this award in celebration of “Measurement Day”, which commemorates October 26 as the day in which King Sejong the Great established a volume measurement system. Professor Kim discovered that the time difference between the pulse of light created by a laser and the pulse of the current produced by a light-emitting diode was as small as 100 attoseconds (10-16 seconds). He then developed a unique multifunctional ultrahigh-speed, high-resolution Time-of-Flight (TOF) sensor that could take measurements of multiple points at the same time by sampling electric light. The sensor, with a measurement speed of 100 megahertz (100 million vibrations per second), a resolution of 180 picometers (1/5.5 billion meters), and a dynamic range of 150 decibels, overcame the limitations of both existing TOF techniques and laser interferometric techniques at the same time. The results of this research were published in Nature Photonics on February 10, 2020. Professor Kim said, “I’d like to thank the graduate students who worked passionately with me, and KAIST for providing an environment in which I could fully focus on research. I am looking forward to the new and diverse applications in the field of machine manufacturing, such as studying the dynamic phenomena in microdevices, or taking ultraprecision measurement of shapes for advanced manufacturing.” (END)
Professor Won-Ki Cho Selected as the 2020 SUHF Young Investigator
Professor Won-Ki Cho from the Department of Biological Sciences was named one of three recipients of the 2020 Suh Kyung-Bae Science Foundation (SUHF) Young Investigator Award. The SUHF is a non-profit organization established in 2016 and funded by a personal donation of 300 billion KRW in shares from Chairman and CEO Kyung-Bae Suh of the Amorepacific Group. The primary purpose of the foundation is to serve as a platform to nurture and provide comprehensive long-term support for creative and passionate young Korean scientists committed to pursuing research in the field of life sciences. The SUHF selects three to five scientists through an open recruiting process every year and grants each scientist a maximum of 2.5 billion KRW over a period of up to five years. Since January this year, the foundation received 67 research proposals from scientists across the nation, especially from those who had less than five years of experience as professors, and selected the three recipients. Professor Cho proposed research on how to observe the interactions between nuclear structures and constantly-changing chromatin monomers in four dimensions through ultra-high-resolution imaging of single living cells. This proposal was recognized as one that could help us better understand the process of transcription regulation, which remains a long-standing question in biology. The other awards were given to Professor Soung-hun Roh of Seoul National University and Professor Joo-Hyeon Lee of the University of Cambridge. With these three new awardees, a total of 17 scientists have been named SUHF Young Investigators to date, and the funding to support these scientists now totals 42.5 billion KRW. Professor Inkyung Jung and Professor Ki-Jun Yoon from the Department of Biological Sciences, and Professor Young Seok Ju and Professor Jeong Ho Lee from the Graduate School of Medical Science and Engineering are the four previous winners from KAIST in the years 2017 through 2019. (END)
Slippery When Wet: Fish and Seaweed Inspire Ships to Reduce Fluid Friction
Faster ships could be on the horizon after KAIST scientists develop a slippery surface inspired by fish and seaweed to reduce the hull's drag through the water. Long-distance cargo ships lose a significant amount of energy due to fluid friction. Looking to the drag reduction mechanisms employed by aquatic life can provide inspiration on how to improve efficiency. Fish and seaweed secrete a layer of mucus to create a slippery surface, reducing their friction as they travel through water. A potential way to mimic this is by creating lubricant-infused surfaces covered with cavities. As the cavities are continuously filled with the lubricant, a layer is formed over the surface. Though this method has previously been shown to work, reducing drag by up to 18%, the underlying physics is not fully understood. KAIST researchers in collaboration with a team of researchers from POSTECH conducted simulations of this process to help explain the effects, and their findings were published in the journal Physics of Fluids on September 15. The group looked at the average speed of a cargo ship with realistic material properties and simulated how it behaves under various lubrication setups. Specifically, they monitored the effects of the open area of the lubricant-filled cavities, as well as the thickness of the cavity lids. They found that for larger open areas, the lubricant spreads more than it does with smaller open areas, leading to a slipperier surface. On the other hand, the lid thickness does not have much of an effect on the slip, though a thicker lid does create a thicker lubricant buildup layer. Professor Emeritus Hyung Jin Sung from the KAIST Department of Mechanical Engineering who led this study said, “Our investigation of the hydrodynamics of a lubricant layer and how it results in drag reduction with a slippery surface in a basic configuration has provided significant insight into the benefits of a lubricant-infused surface.” Now that they have worked on optimizing the lubricant secretion design, the authors hope it can be implemented in real-life marine vehicles. “If the present design parameters are adopted, the drag reduction rate will increase significantly,” Professor Sung added. This work was supported by the National Research Foundation (NRF) of Korea. Source: Materials provided by American Institute of Physics. Publication: Kim, Seung Joong, et al. (2020). A lubricant-infused slip surface for drag reduction. Physics of Fluids. Available online at https://doi.org/10.1063/5.0018460 Profile: Hyung Jin Sung Professor Emeritus email@example.com http://flow.kaist.ac.kr/index.php Flow Control Lab. (FCL) Department of Mechanical Engineering http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
Big Ideas on Emerging Materials Explored at EMS
Renowned scholars and editors from academic journals joined the Emerging Materials e-Symposium (EMS) held at KAIST and shared the latest breakthroughs and big ideas in new material development last month. This e-symposium was organized by Professor Il-Doo Kim from the KAIST Department of Materials Sciences and Engineering over five days from September 21 through 25 via Zoom and YouTube. Professor Kim also serves as an associate editor of ACS Nano. Esteemed scholars and editors of academic journals including ACS Nano, Nano Energy, and Energy Storage Materials made Zoom presentations in three main categories: 1) nanostructures for next-generation applications, 2) chemistry and biotechnology for applications in the fields of environment and industry, and 3) material innovation for technological applications. During Session I, speakers including Professor John A. Rogers of Northwestern University and Professor Zhenan Bao of Stanford University led the session on Emerging Soft Electronics and 3D printing. In later sessions, other globally recognized scholars gave talks titled Advanced Nanostructuring for Emerging Materials, Frontiers in Emerging Materials Research, Advanced Energy Materials and Functional Nanomaterials, and Latest Advances in Nanomaterials Research. These included 2010 Nobel Prize laureate and professor at Manchester University Andre Geim, editor-in-chief of ACS Nano and professor at UCLA Paul S. Weiss, Professor Paul Alivisatos of UC Berkeley, Professor William Chueh of Stanford University, and Professor Mircea Dinca of MIT. KAIST President Sung-Chul Shin, who is also a materials physicist, said in his opening address, “Innovation in materials science will become an important driving force to change our way of life. All the breakthroughs in materials have extended a new paradigm that has transformed our lives.” “Creative research projects alongside global collaborators like all of you will allow the breakthroughs that will deliver us from these crises,” he added. (END)
E. coli Engineered to Grow on CO₂ and Formic Acid as Sole Carbon Sources
- An E. coli strain that can grow to a relatively high cell density solely on CO₂ and formic acid was developed by employing metabolic engineering. - Most biorefinery processes have relied on the use of biomass as a raw material for the production of chemicals and materials. Even though the use of CO₂ as a carbon source in biorefineries is desirable, it has not been possible to make common microbial strains such as E. coli grow on CO₂. Now, a metabolic engineering research group at KAIST has developed a strategy to grow an E. coli strain to higher cell density solely on CO₂ and formic acid. Formic acid is a one carbon carboxylic acid, and can be easily produced from CO₂ using a variety of methods. Since it is easier to store and transport than CO₂, formic acid can be considered a good liquid-form alternative of CO₂. With support from the C1 Gas Refinery R&D Center and the Ministry of Science and ICT, a research team led by Distinguished Professor Sang Yup Lee stepped up their work to develop an engineered E. coli strain capable of growing up to 11-fold higher cell density than those previously reported, using CO₂ and formic acid as sole carbon sources. This work was published in Nature Microbiology on September 28. Despite the recent reports by several research groups on the development of E. coli strains capable of growing on CO₂ and formic acid, the maximum cell growth remained too low (optical density of around 1) and thus the production of chemicals from CO₂ and formic acid has been far from realized. The team previously reported the reconstruction of the tetrahydrofolate cycle and reverse glycine cleavage pathway to construct an engineered E. coli strain that can sustain growth on CO₂ and formic acid. To further enhance the growth, the research team introduced the previously designed synthetic CO₂ and formic acid assimilation pathway, and two formate dehydrogenases. Metabolic fluxes were also fine-tuned, the gluconeogenic flux enhanced, and the levels of cytochrome bo3 and bd-I ubiquinol oxidase for ATP generation were optimized. This engineered E. coli strain was able to grow to a relatively high OD600 of 7~11, showing promise as a platform strain growing solely on CO₂ and formic acid. Professor Lee said, “We engineered E. coli that can grow to a higher cell density only using CO₂ and formic acid. We think that this is an important step forward, but this is not the end. The engineered strain we developed still needs further engineering so that it can grow faster to a much higher density.” Professor Lee’s team is continuing to develop such a strain. “In the future, we would be delighted to see the production of chemicals from an engineered E. coli strain using CO₂ and formic acid as sole carbon sources,” he added. Profile: Distinguished Professor Sang Yup Lee firstname.lastname@example.org http://mbel.kaist.ac.kr Department of Chemical and Biomolecular Engineering KAIST
Deep Learning Helps Explore the Structural and Strategic Bases of Autism
Psychiatrists typically diagnose autism spectrum disorders (ASD) by observing a person’s behavior and by leaning on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), widely considered the “bible” of mental health diagnosis. However, there are substantial differences amongst individuals on the spectrum and a great deal remains unknown by science about the causes of autism, or even what autism is. As a result, an accurate diagnosis of ASD and a prognosis prediction for patients can be extremely difficult. But what if artificial intelligence (AI) could help? Deep learning, a type of AI, deploys artificial neural networks based on the human brain to recognize patterns in a way that is akin to, and in some cases can surpass, human ability. The technique, or rather suite of techniques, has enjoyed remarkable success in recent years in fields as diverse as voice recognition, translation, autonomous vehicles, and drug discovery. A group of researchers from KAIST in collaboration with the Yonsei University College of Medicine has applied these deep learning techniques to autism diagnosis. Their findings were published on August 14 in the journal IEEE Access. Magnetic resonance imaging (MRI) scans of brains of people known to have autism have been used by researchers and clinicians to try to identify structures of the brain they believed were associated with ASD. These researchers have achieved considerable success in identifying abnormal grey and white matter volume and irregularities in cerebral cortex activation and connections as being associated with the condition. These findings have subsequently been deployed in studies attempting more consistent diagnoses of patients than has been achieved via psychiatrist observations during counseling sessions. While such studies have reported high levels of diagnostic accuracy, the number of participants in these studies has been small, often under 50, and diagnostic performance drops markedly when applied to large sample sizes or on datasets that include people from a wide variety of populations and locations. “There was something as to what defines autism that human researchers and clinicians must have been overlooking,” said Keun-Ah Cheon, one of the two corresponding authors and a professor in Department of Child and Adolescent Psychiatry at Severance Hospital of the Yonsei University College of Medicine. “And humans poring over thousands of MRI scans won’t be able to pick up on what we’ve been missing,” she continued. “But we thought AI might be able to.” So the team applied five different categories of deep learning models to an open-source dataset of more than 1,000 MRI scans from the Autism Brain Imaging Data Exchange (ABIDE) initiative, which has collected brain imaging data from laboratories around the world, and to a smaller, but higher-resolution MRI image dataset (84 images) taken from the Child Psychiatric Clinic at Severance Hospital, Yonsei University College of Medicine. In both cases, the researchers used both structural MRIs (examining the anatomy of the brain) and functional MRIs (examining brain activity in different regions). The models allowed the team to explore the structural bases of ASD brain region by brain region, focusing in particular on many structures below the cerebral cortex, including the basal ganglia, which are involved in motor function (movement) as well as learning and memory. Crucially, these specific types of deep learning models also offered up possible explanations of how the AI had come up with its rationale for these findings. “Understanding the way that the AI has classified these brain structures and dynamics is extremely important,” said Sang Wan Lee, the other corresponding author and an associate professor at KAIST. “It’s no good if a doctor can tell a patient that the computer says they have autism, but not be able to say why the computer knows that.” The deep learning models were also able to describe how much a particular aspect contributed to ASD, an analysis tool that can assist psychiatric physicians during the diagnosis process to identify the severity of the autism. “Doctors should be able to use this to offer a personalized diagnosis for patients, including a prognosis of how the condition could develop,” Lee said. “Artificial intelligence is not going to put psychiatrists out of a job,” he explained. “But using AI as a tool should enable doctors to better understand and diagnose complex disorders than they could do on their own.” -Profile Professor Sang Wan Lee Department of Bio and Brain Engineering Laboratory for Brain and Machine Intelligence https://aibrain.kaist.ac.kr/ KAIST
Biomarker Predicts Who Will Have Severe COVID-19
- Airway cell analyses showing an activated immune axis could pinpoint the COVID-19 patients who will most benefit from targeted therapies.- KAIST researchers have identified key markers that could help pinpoint patients who are bound to get a severe reaction to COVID-19 infection. This would help doctors provide the right treatments at the right time, potentially saving lives. The findings were published in the journal Frontiers in Immunology on August 28. People’s immune systems react differently to infection with SARS-CoV-2, the virus that causes COVID-19, ranging from mild to severe, life-threatening responses. To understand the differences in responses, Professor Heung Kyu Lee and PhD candidate Jang Hyun Park from the Graduate School of Medical Science and Engineering at KAIST analysed ribonucleic acid (RNA) sequencing data extracted from individual airway cells of healthy controls and of mildly and severely ill patients with COVID-19. The data was available in a public database previously published by a group of Chinese researchers. “Our analyses identified an association between immune cells called neutrophils and special cell receptors that bind to the steroid hormone glucocorticoid,” Professor Lee explained. “This finding could be used as a biomarker for predicting disease severity in patients and thus selecting a targeted therapy that can help treat them at an appropriate time,” he added. Severe illness in COVID-19 is associated with an exaggerated immune response that leads to excessive airway-damaging inflammation. This condition, known as acute respiratory distress syndrome (ARDS), accounts for 70% of deaths in fatal COVID-19 infections. Scientists already know that this excessive inflammation involves heightened neutrophil recruitment to the airways, but the detailed mechanisms of this reaction are still unclear. Lee and Park’s analyses found that a group of immune cells called myeloid cells produced excess amounts of neutrophil-recruiting chemicals in severely ill patients, including a cytokine called tumour necrosis factor (TNF) and a chemokine called CXCL8. Further RNA analyses of neutrophils in severely ill patients showed they were less able to recruit very important T cells needed for attacking the virus. At the same time, the neutrophils produced too many extracellular molecules that normally trap pathogens, but damage airway cells when produced in excess. The researchers additionally found that the airway cells in severely ill patients were not expressing enough glucocorticoid receptors. This was correlated with increased CXCL8 expression and neutrophil recruitment. Glucocorticoids, like the well-known drug dexamethasone, are anti-inflammatory agents that could play a role in treating COVID-19. However, using them in early or mild forms of the infection could suppress the necessary immune reactions to combat the virus. But if airway damage has already happened in more severe cases, glucocorticoid treatment would be ineffective. Knowing who to give this treatment to and when is really important. COVID-19 patients showing reduced glucocorticoid receptor expression, increased CXCL8 expression, and excess neutrophil recruitment to the airways could benefit from treatment with glucocorticoids to prevent airway damage. Further research is needed, however, to confirm the relationship between glucocorticoids and neutrophil inflammation at the protein level. “Our study could serve as a springboard towards more accurate and reliable COVID-19 treatments,” Professor Lee said. This work was supported by the National Research Foundation of Korea, and Mobile Clinic Module Project funded by KAIST. Figure. Low glucocorticoid receptor (GR) expression led to excessive inflammation and lung damage by neutrophils through enhancing the expression of CXCL8 and other cytokines. Image credit: Professor Heung Kyu Lee, KAIST. Created with Biorender.com. Image usage restrictions: News organizations may use or redistribute these figures and image, with proper attribution, as part of news coverage of this paper only. Publication: Jang Hyun Park, and Heung Kyu Lee. (2020). Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19. Frontiers in Immunology, Available online at https://doi.org/10.3389/fimmu.2020.02145 Profile: Heung Kyu Lee Associate Professor email@example.com https://www.heungkyulee.kaist.ac.kr/ Laboratory of Host Defenses Graduate School of Medical Science and Engineering (GSMSE) The Center for Epidemic Preparedness at KAIST Institute http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea Profile: Jang Hyun Park PhD Candidate firstname.lastname@example.org GSMSE, KAIST (END)
Sturdy Fabric-Based Piezoelectric Energy Harvester Takes Us One Step Closer to Wearable Electronics
KAIST researchers presented a highly flexible but sturdy wearable piezoelectric harvester using the simple and easy fabrication process of hot pressing and tape casting. This energy harvester, which has record high interfacial adhesion strength, will take us one step closer to being able to manufacture embedded wearable electronics. A research team led by Professor Seungbum Hong said that the novelty of this result lies in its simplicity, applicability, durability, and its new characterization of wearable electronic devices. Wearable devices are increasingly being used in a wide array of applications from small electronics to embedded devices such as sensors, actuators, displays, and energy harvesters. Despite their many advantages, high costs and complex fabrication processes remained challenges for reaching commercialization. In addition, their durability was frequently questioned. To address these issues, Professor Hong’s team developed a new fabrication process and analysis technology for testing the mechanical properties of affordable wearable devices. For this process, the research team used a hot pressing and tape casting procedure to connect the fabric structures of polyester and a polymer film. Hot pressing has usually been used when making batteries and fuel cells due to its high adhesiveness. Above all, the process takes only two to three minutes. The newly developed fabrication process will enable the direct application of a device into general garments using hot pressing just as graphic patches can be attached to garments using a heat press. In particular, when the polymer film is hot pressed onto a fabric below its crystallization temperature, it transforms into an amorphous state. In this state, it compactly attaches to the concave surface of the fabric and infiltrates into the gaps between the transverse wefts and longitudinal warps. These features result in high interfacial adhesion strength. For this reason, hot pressing has the potential to reduce the cost of fabrication through the direct application of fabric-based wearable devices to common garments. In addition to the conventional durability test of bending cycles, the newly introduced surface and interfacial cutting analysis system proved the high mechanical durability of the fabric-based wearable device by measuring the high interfacial adhesion strength between the fabric and the polymer film. Professor Hong said the study lays a new foundation for the manufacturing process and analysis of wearable devices using fabrics and polymers. He added that his team first used the surface and interfacial cutting analysis system (SAICAS) in the field of wearable electronics to test the mechanical properties of polymer-based wearable devices. Their surface and interfacial cutting analysis system is more precise than conventional methods (peel test, tape test, and microstretch test) because it qualitatively and quantitatively measures the adhesion strength. Professor Hong explained, “This study could enable the commercialization of highly durable wearable devices based on the analysis of their interfacial adhesion strength. Our study lays a new foundation for the manufacturing process and analysis of other devices using fabrics and polymers. We look forward to fabric-based wearable electronics hitting the market very soon.” The results of this study were registered as a domestic patent in Korea last year, and published in Nano Energy this month. This study has been conducted through collaboration with Professor Yong Min Lee in the Department of Energy Science and Engineering at DGIST, Professor Kwangsoo No in the Department of Materials Science and Engineering at KAIST, and Professor Seunghwa Ryu in the Department of Mechanical Engineering at KAIST. This study was supported by the High-Risk High-Return Project and the Global Singularity Research Project at KAIST, the National Research Foundation, and the Ministry of Science and ICT in Korea. -Publication: Jaegyu Kim, Seoungwoo Byun, Sangryun Lee, Jeongjae Ryu, Seongwoo Cho, Chungik Oh, Hongjun Kim, Kwangsoo No, Seunghwa Ryu, Yong Min Lee, Seungbum Hong*, Nano Energy 75 (2020), 104992. https://doi.org/10.1016/j.nanoen.2020.104992 -Profile: Professor Seungbum Hong email@example.com http://mii.kaist.ac.kr/ Department of Materials Science and Engineering KAIST
Advanced NVMe Controller Technology for Next Generation Memory Devices
KAIST researchers advanced non-volatile memory express (NVMe) controller technology for next generation information storage devices, and made this new technology named ‘OpenExpress’ freely available to all universities and research institutes around the world to help reduce the research cost in related fields. NVMe is a communication protocol made for high-performance storage devices based on a peripheral component interconnect-express (PCI-E) interface. NVMe has been developed to take the place of the Serial AT Attachment (SATA) protocol, which was developed to process data on hard disk drives (HDDs) and did not perform well in solid state drives (SSDs). Unlike HDDs that use magnetic spinning disks, SSDs use semiconductor memory, allowing the rapid reading and writing of data. SSDs also generate less heat and noise, and are much more compact and lightweight. Since data processing in SSDs using NVMe is up to six times faster than when SATA is used, NVMe has become the standard protocol for ultra-high speed and volume data processing, and is currently used in many flash-based information storage devices. Studies on NVMe continue at both the academic and industrial levels, however, its poor accessibility is a drawback. Major information and communications technology (ICT) companies around the world expend astronomical costs to procure intellectual property (IP) related to hardware NVMe controllers, necessary for the use of NVMe. However, such IP is not publicly disclosed, making it difficult to be used by universities and research institutes for research purposes. Although a small number of U.S. Silicon Valley startups provide parts of their independently developed IP for research, the cost of usage is around 34,000 USD per month. The costs skyrocket even further because each copy of single-use source code purchased for IP modification costs approximately 84,000 USD. In order to address these issues, a group of researchers led by Professor Myoungsoo Jung from the School of Electrical Engineering at KAIST developed a next generation NVMe controller technology that achieved parallel data input/output processing for SSDs in a fully hardware automated form. The researchers presented their work at the 2020 USENIX Annual Technical Conference (USENIX ATC ’20) in July, and released it as an open research framework named ‘OpenExpress.’ This NVMe controller technology developed by Professor Jung’s team comprises a wide range of basic hardware IP and key NVMe IP cores. To examine its actual performance, the team made an NVMe hardware controller prototype using OpenExpress, and designed all logics provided by OpenExpress to operate at high frequency. The field-programmable gate array (FPGA) memory card prototype developed using OpenExpress demonstrated increased input/output data processing capacity per second, supporting up to 7 gigabit per second (GB/s) bandwidth. This makes it suitable for ultra-high speed and volume next generation memory device research. In a test comparing various storage server loads on devices, the team’s FPGA also showed 76% higher bandwidth and 68% lower input/output delay compared to Intel’s new high performance SSD (Optane SSD), which is sufficient for many researchers studying systems employing future memory devices. Depending on user needs, silicon devices can be synthesized as well, which is expected to further enhance performance. The NVMe controller technology of Professor Jung’s team can be freely used and modified under the OpenExpress open-source end-user agreement for non-commercial use by all universities and research institutes. This makes it extremely useful for research on next-generation memory compatible NVMe controllers and software stacks. “With the product of this study being disclosed to the world, universities and research institutes can now use controllers that used to be exclusive for only the world’s biggest companies, at no cost,ˮ said Professor Jung. He went on to stress, “This is a meaningful first step in research of information storage device systems such as high-speed and volume next generation memory.” This work was supported by a grant from MemRay, a company specializing in next generation memory development and distribution. More details about the study can be found at http://camelab.org. Image credit: Professor Myoungsoo Jung, KAIST Image usage restrictions: News organizations may use or redistribute these figures and image, with proper attribution, as part of news coverage of this paper only. Publication: Myoungsoo Jung. (2020). OpenExpress: Fully Hardware Automated Open Research Framework for Future Fast NVMe Devices. Presented in the Proceedings of the 2020 USENIX Annual Technical Conference (USENIX ATC ’20), Available online at https://www.usenix.org/system/files/atc20-jung.pdf Profile: Myoungsoo Jung, PhD. Associate Professor firstname.lastname@example.org http://camelab.org Computer Architecture and Memory Systems Laboratory School of Electrical Engineering http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea (END)
Before Eyes Open, They Get Ready to See
- Spontaneous retinal waves can generate long-range horizontal connectivity in visual cortex. - A KAIST research team’s computational simulations demonstrated that the waves of spontaneous neural activity in the retinas of still-closed eyes in mammals develop long-range horizontal connections in the visual cortex during early developmental stages. This new finding featured in the August 19 edition of Journal of Neuroscience as a cover article has resolved a long-standing puzzle for understanding visual neuroscience regarding the early organization of functional architectures in the mammalian visual cortex before eye-opening, especially the long-range horizontal connectivity known as “feature-specific” circuitry. To prepare the animal to see when its eyes open, neural circuits in the brain’s visual system must begin developing earlier. However, the proper development of many brain regions involved in vision generally requires sensory input through the eyes. In the primary visual cortex of the higher mammalian taxa, cortical neurons of similar functional tuning to a visual feature are linked together by long-range horizontal circuits that play a crucial role in visual information processing. Surprisingly, these long-range horizontal connections in the primary visual cortex of higher mammals emerge before the onset of sensory experience, and the mechanism underlying this phenomenon has remained elusive. To investigate this mechanism, a group of researchers led by Professor Se-Bum Paik from the Department of Bio and Brain Engineering at KAIST implemented computational simulations of early visual pathways using data obtained from the retinal circuits in young animals before eye-opening, including cats, monkeys, and mice. From these simulations, the researchers found that spontaneous waves propagating in ON and OFF retinal mosaics can initialize the wiring of long-range horizontal connections by selectively co-activating cortical neurons of similar functional tuning, whereas equivalent random activities cannot induce such organizations. The simulations also showed that emerged long-range horizontal connections can induce the patterned cortical activities, matching the topography of underlying functional maps even in salt-and-pepper type organizations observed in rodents. This result implies that the model developed by Professor Paik and his group can provide a universal principle for the developmental mechanism of long-range horizontal connections in both higher mammals as well as rodents. Professor Paik said, “Our model provides a deeper understanding of how the functional architectures in the visual cortex can originate from the spatial organization of the periphery, without sensory experience during early developmental periods.” He continued, “We believe that our findings will be of great interest to scientists working in a wide range of fields such as neuroscience, vision science, and developmental biology.” This work was supported by the National Research Foundation of Korea (NRF). Undergraduate student Jinwoo Kim participated in this research project and presented the findings as the lead author as part of the Undergraduate Research Participation (URP) Program at KAIST. Figures and image credit: Professor Se-Bum Paik, KAIST Image usage restrictions: News organizations may use or redistribute these figures and image, with proper attribution, as part of news coverage of this paper only. Publication: Jinwoo Kim, Min Song, and Se-Bum Paik. (2020). Spontaneous retinal waves generate long-range horizontal connectivity in visual cortex. Journal of Neuroscience, Available online athttps://www.jneurosci.org/content/early/2020/07/17/JNEUROSCI.0649-20.2020 Profile: Se-Bum Paik Assistant Professor email@example.com http://vs.kaist.ac.kr/ VSNN Laboratory Department of Bio and Brain Engineering Program of Brain and Cognitive Engineering http://kaist.ac.kr Korea Advanced Institute of Science and Technology (KAIST) Daejeon, Republic of Korea Profile: Jinwoo Kim Undergraduate Student firstname.lastname@example.org Department of Bio and Brain Engineering, KAIST Profile: Min Song Ph.D. Candidate email@example.com Program of Brain and Cognitive Engineering, KAIST (END)
Microscopy Approach Poised to Offer New Insights into Liver Diseases
Researchers have developed a new way to visualize the progression of nonalcoholic fatty liver disease (NAFLD) in mouse models of the disease. The new microscopy method provides a high-resolution 3D view that could lead to important new insights into NAFLD, a condition in which too much fat is stored in the liver. “It is estimated that a quarter of the adult global population has NAFLD, yet an effective treatment strategy has not been found,” said professor Pilhan Kim from the Graduate School of Medical Science and Engineering at KAIST. “NAFLD is associated with obesity and type 2 diabetes and can sometimes progress to liver failure in serious case.” In the Optical Society (OSA) journal Biomedical Optics Express, Professor Kim and colleagues reported their new imaging technique and showed that it can be used to observe how tiny droplets of fat, or lipids, accumulate in the liver cells of living mice over time. “It has been challenging to find a treatment strategy for NAFLD because most studies examine excised liver tissue that represents just one timepoint in disease progression,” said Professor Kim. “Our technique can capture details of lipid accumulation over time, providing a highly useful research tool for identifying the multiple parameters that likely contribute to the disease and could be targeted with treatment.” Capturing the dynamics of NAFLD in living mouse models of the disease requires the ability to observe quickly changing interactions of biological components in intact tissue in real-time. To accomplish this, the researchers developed a custom intravital confocal and two-photon microscopy system that acquires images of multiple fluorescent labels at video-rate with cellular resolution. “With video-rate imaging capability, the continuous movement of liver tissue in live mice due to breathing and heart beating could be tracked in real time and precisely compensated,” said Professor Kim. “This provided motion-artifact free high-resolution images of cellular and sub-cellular sized individual lipid droplets.” The key to fast imaging was a polygonal mirror that rotated at more than 240 miles per hour to provide extremely fast laser scanning. The researchers also incorporated four different lasers and four high-sensitivity optical detectors into the setup so that they could acquire multi-color images to capture different color fluorescent probes used to label the lipid droplets and microvasculature in the livers of live mice. “Our approach can capture real-time changes in cell behavior and morphology, vascular structure and function, and the spatiotemporal localization of biological components while directly visualizing of lipid droplet development in NAFLD progression,” said Professor Kim. “It also allows the analysis of the highly complex behaviors of various immune cells as NAFLD progresses.” The researchers demonstrated their approach by using it to observe the development and spatial distribution of lipid droplets in individual mice with NAFLD induced by a methionine and choline-deficient diet. Next, they plan to use it to study how the liver microenvironment changes during NAFLD progression by imaging the same mouse over time. They also want to use their microscope technique to visualize various immune cells and lipid droplets to better understand the complex liver microenvironment in NAFLD progression.
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