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KAIST-KBSI, ‘Communication’ Between Proteins Found to Mitigate Alzheimer’s Toxicity… Opening the Path to Treatment 50 million people worldwide are estimated to have dementia, with Alzheimer’s disease—accounting for over 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for the first time in the world, identified at the molecular level that tau and amyloid-β, the two key pathological proteins of Alzheimer’s disease, directly communicate to regulate toxicity. This achievement is expected to provide new insights into the pathophysiology of Alzheimer’s disease, as well as important clues for discovering biomarkers for early diagnosis and developing therapeutics for neurodegenerative brain disorders. KAIST (President Kwang Hyung Lee) announced on the 24th of August that Professor Mi Hee Lim’s research team in the Department of Chemistry (Director of the Research Center for Metal–Neuroprotein Interactions), in collaboration with Dr. Young-Ho Lee’s team from the Division of Advanced Biomedical Research at the Korea Basic Science Institute (KBSI, President Sung-kwang Yang) under the National Research Council of Science & Technology (NST, Chairperson Yeung-Shik Kim), together with Dr. Yun Kyung Kim and Dr. Sung Su Lim from the Brain Science Institute at the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh), has elucidated at the molecular level that the microtubule-binding domain of tau—one of the major pathological proteins of Alzheimer’s disease—directly interacts with amyloid-β (tau–amyloid-β communication), alters its aggregation pathway, and alleviates cellular toxicity. Pathologically, Alzheimer’s disease is characterized by the accumulation of“neurofibrillary tangles” formed by aggregates of tau, a protein responsible for transporting nutrients and signaling molecules within neurons, and “amyloid plaques (senile plaques)” formed by clusters of amyloid-β fragments—abnormally cleaved from amyloid precursor protein, which is involved in brain development, intercellular signaling, and neuronal recovery—that aggregate in and around neuronal membranes in the brain. Although tau and amyloid-β form pathological structures in spatially separated locations, it has been suggested that they may coexist inside and outside of cells and potentially interact. However, the molecular-level understanding of how their direct interaction affects the onset and progression of the disease has not been clearly revealed until now. The joint research team found that among the structural repeats of tau protein that bind to microtubules (the intracellular transport system) inside neurons—K18, R1–R4, PHF6*, and PHF6—specifically K18, R2, and R3 bind with amyloid-β to form ‘tau–amyloid-β heterocomplexes.’ This process is significant because amyloid-β normally assembles into highly toxic, rigid fibers (amyloid fibrils), but when certain tau regions bind, amyloid-β shifts to an aggregation pathway that produces less toxic, less rigid aggregates. Notably, these repeat regions of tau delay the nucleation stage (the initial step of amyloid aggregation linked to disease onset) and simultaneously alter the aggregation speed and structural form of amyloid-β associated with disease progression. As a result, the toxicity caused by amyloid-β was markedly reduced in both the intracellular and extracellular environments of the brain. In this study, the team combined precise analytical techniques—including spectroscopy, mass spectrometry, isothermal titration calorimetry, and nuclear magnetic resonance—with cell-based toxicity assays to comprehensively analyze the structural, thermodynamic, and functional properties of tau–amyloid interactions. The findings revealed that specific regions of tau’s microtubule-binding repeats possess both hydrophilic (water-attracting) and hydrophobic (water-repelling) characteristics, and when the balance of these two properties is optimized, tau binds more effectively to amyloid-β. In other words, the intrinsic properties of tau determine its binding affinity with amyloid-β, its modulation of aggregation pathways, and its ability to regulate toxicity. Dr. Young-Ho Lee of KBSI stated, “This research has uncovered a new molecular mechanism for the onset and progression of dementia, an intractable neurodegenerative disease. In particular, multidisciplinary convergent research focused on molecular interactions and protein aggregation is expected to play a pivotal role in clarifying not only the cross-talk between Alzheimer’s and Parkinson’s diseases but also the interconnections among various diseases such as dementia, diabetes, and cancer.” Professor Mi Hee Lim of KAIST added, “Tau protein does not merely contribute to pathological formation, but rather, through specific microtubule-binding repeat structures, it exerts a molecular function that actively mitigates amyloid-β aggregation and toxicity. This provides a new turning point in the pathological understanding of Alzheimer’s disease. The significance of this study lies in identifying new molecular motifs that could serve as therapeutic targets not only for Alzheimer’s but also for a variety of protein aggregation-based neurodegenerative brain disorders.” This research, with Dr. Min Geun Kim of KAIST’s Department of Chemistry as first author, was published on August 22 in the internationally renowned journal Nature Chemical Biology (Impact factor: 13.7, top 3.8% in the field of chemistry). ※ Paper Title: “Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity” ※ DOI: 10.1038/s41589-025-01987-0 This research was supported by the National Research Foundation of Korea’s Basic Research Program (Leader Research and Mid-career Researcher Program), the Sejong Science Fellowship, as well as KBSI and KIST.
2025.08.25 View 2215
New and Highly Efficient Recycling Technology to Turn Used Tires into Raw Materials for Rubber and Nylon < (From left) Kyungmin Choi (MS-Ph.D. integrated course, Department of Chemistry), Dr. Beomsoon Park, Professor Soon Hyeok Hong, Dr. Kyoungil Cho > Approximately 1.5 billions of tires are discarded globally every year, and this is identified as one of the major causes of serious environmental pollution. The research team at the Department of Chemistry at KAIST has achieved a breakthrough by selectively converting waste tires into high-purity cyclic alkenes, valuable chemical building blocks used in the production of rubber and nylon fibers. This advance marks a new milestone in chemical recycling technology for waste tires. The team, led by Professor Soon Hyeok Hong, has developed a dual-catalyst-based reaction system that overcomes the long-standing challenges associated with recycling vulcanized rubber materials. Tires are composed of complex blends of synthetic and natural rubber, and their physical strength and durability are reinforced with additives such as silica, carbon black, and antioxidants. In particular, cross-linking between rubber chains is formed through the vulcanization process, giving them a structure resistant to heat and pressure, which is one of the main reasons why chemical recycling of waste tires is difficult. Until now, waste tire recycling has mainly relied on pyrolysis or mechanical recycling methods. The pyrolysis method is a technology that decomposes polymer chains at high temperatures of 350-800°C to convert them into fuel oil, but it clearly has limitations such as high energy consumption, low selectivity, and the production of low-quality hydrocarbon mixtures. To solve these problems, the research team developed a method to convert waste rubber into useful chemicals using dual catalysis. The first catalyst helps to break down rubber molecules by changing their bonding structure, and the second catalyst creates cyclic compounds through a ring-closing reaction. This process shows high selectivity of up to 92% and a yield of 82%. The produced cyclopentene can be recycled into rubber, and cyclohexene can be used as a raw material for nylon fibers, making them industrially very valuable. The research team successfully applied the developed system to discarded waste tires, achieving selective conversion into high-purity cyclic alkenes. Unlike the existing pyrolysis method, this is evaluated as a new turning point in the field of waste tire recycling as it can produce high-value chemicals through low-temperature precision catalytic reactions. In addition, this catalytic platform is compatible with a wide range of synthetic and waste rubbers, positioning it as a promising foundation for scalable, circular solutions in the polymer and materials industries. < Figure 1. Development of a Catalytic Method for Chemical Recycling of Waste Rubber > Professor Hong stated, "This research offers an innovative solution for the chemical recycling of waste tires. We aim to develop next-generation high-efficiency catalysts and lay the groundwork for commercialization to enhance economic feasibility. Ultimately, our goal is to contribute to solving the broader waste plastic problem through fundamental chemistry." This research, in which Beomsoon Park, Kyoungil Cho, and Kyungmin Choi participated, was supported by the National Research Foundation of Korea and was published online in the internationally renowned academic journal ‘Chem’ on June 18th. ※Paper Title: Catalytic and Selective Chemical Recycling of Post-Consumer Rubbers into Cycloalkenes ※DOI: 10.1016/j.chempr.2025.102625
2025.06.26 View 4942
Simultaneous Analysis of 21 Chemical Reactions... AI to Transform New Drug Development < Photo 1. (From left) Professor Hyunwoo Kim and students Donghun Kim and Gyeongseon Choi in the Integrated M.S./Ph.D. program of the Department of Chemistry > Thalidomide, a drug once used to alleviate morning sickness in pregnant women, exhibits distinct properties due to its optical isomers* in the body: one isomer has a sedative effect, while the other causes severe side effects like birth defects. As this example illustrates, precise organic synthesis techniques, which selectively synthesize only the desired optical isomer, are crucial in new drug development. Overcoming the traditional methods that struggled with simultaneously analyzing multiple reactants, our research team has developed the world's first technology to precisely analyze 21 types of reactants simultaneously. This breakthrough is expected to make a significant contribution to new drug development utilizing AI and robots. *Optical Isomers: A pair of molecules with the same chemical formula that are mirror images of each other and cannot be superimposed due to their asymmetric structure. This is analogous to a left and right hand, which are similar in form but cannot be perfectly overlaid. KAIST's Professor Hyunwoo Kim's research team in the Department of Chemistry announced on the 16th that they have developed an innovative optical isomer analysis technology suitable for the era of AI-driven autonomous synthesis*. This research is the world's first technology to precisely analyze asymmetric catalytic reactions involving multiple reactants simultaneously using high-resolution fluorine nuclear magnetic resonance spectroscopy (19F NMR). It is expected to make groundbreaking contributions to various fields, including new drug development and catalyst optimization. *AI-driven Autonomous Synthesis: An advanced technology that automates and optimizes chemical substance synthesis processes using artificial intelligence (AI). It is gaining attention as a core element for realizing automated and intelligent research environments in future laboratories. AI predicts and adjusts experimental conditions, interprets results, and designs subsequent experiments independently, minimizing human intervention in repetitive experiments and significantly increasing research efficiency and innovativeness. Currently, while autonomous synthesis systems can automate everything from reaction design to execution, reaction analysis still relies on individual processing using traditional equipment. This leads to slower speeds and bottlenecks, making it unsuitable for high-speed repetitive experiments. Furthermore, multi-substrate simultaneous screening techniques proposed in the 1990s garnered attention as a strategy to maximize reaction analysis efficiency. However, limitations of existing chromatography-based analysis methods restricted the number of applicable substrates. In asymmetric synthesis reactions, which selectively synthesize only the desired optical isomer, simultaneously analyzing more than 10 types of substrates was nearly impossible. < Figure 1. Conventional organic reaction evaluation methods follow a process of deriving optimal reaction conditions using a single substrate, then expanding the substrate scope one by one under those conditions, leaving potential reaction areas unexplored. To overcome this, high-throughput screening is introduced to broadly explore catalyst reactivity for various substrates. When combined with multi-substrate screening, this approach allows for a much broader and more systematic understanding of reaction scope and trends. > To overcome these limitations, the research team developed a 19F NMR-based multi-substrate simultaneous screening technology. This method involves performing asymmetric catalytic reactions with multiple reactants in a single reaction vessel, introducing a fluorine functional group into the products, and then applying their self-developed chiral cobalt reagent to clearly quantify all optical isomers using 19F NMR. Utilizing the excellent resolution and sensitivity of 19F NMR, the research team successfully performed asymmetric synthesis reactions of 21 substrates simultaneously in a single reaction vessel and quantitatively measured the product yield and optical isomer ratio without any separate purification steps. Professor Hyunwoo Kim stated, "While anyone can perform asymmetric synthesis reactions with multiple substrates in one reactor, accurately analyzing all the products has been a challenging problem to solve until now. We expect that achieving world-class multi-substrate screening analysis technology will greatly contribute to enhancing the analytical capabilities of AI-driven autonomous synthesis platforms." < Figure 2. A method for analyzing multi-substrate asymmetric catalytic reactions, where different substrates react simultaneously in a single reactor, using fluorine nuclear magnetic resonance has been implemented. By utilizing the characteristics of fluorine nuclear magnetic resonance, which has a clean background signal and a wide chemical shift range, the reactivity of each substrate can be quantitatively analyzed. It is also shown that the optical activity of all reactants can be simultaneously measured using a cobalt metal complex. > He further added, "This research provides a technology that can rapidly verify the efficiency and selectivity of asymmetric catalytic reactions essential for new drug development, and it is expected to be utilized as a core analytical tool for AI-driven autonomous research." < Figure 3. It can be seen that in a multi-substrate reductive amination reaction using a total of 21 substrates, the yield and optical activity of the reactants according to the catalyst system were simultaneously measured using a fluorine nuclear magnetic resonance-based analysis platform. The yield of each reactant is indicated by color saturation, and the optical activity by numbers. > Donghun Kim (first author, Integrated M.S./Ph.D. program) and Gyeongseon Choi (second author, Integrated M.S./Ph.D. program) from the KAIST Department of Chemistry participated in this research. The study was published online in the Journal of the American Chemical Society on May 27, 2025.※ Paper Title: One-pot Multisubstrate Screening for Asymmetric Catalysis Enabled by 19F NMR-based Simultaneous Chiral Analysis※ DOI: 10.1021/jacs.5c03446 This research was supported by the National Research Foundation of Korea's Mid-Career Researcher Program, the Asymmetric Catalytic Reaction Design Center, and the KAIST KC30 Project. < Figure 4. Conceptual diagram of performing multi-substrate screening reactions and utilizing fluorine nuclear magnetic resonance spectroscopy. >
2025.06.16 View 5726
“One Experiment Is All It Takes”: KAIST Team Revolutionizes Drug Interaction Testing, Replacing 60,000 Studies A groundbreaking new method developed by researchers at KAIST and Chungnam National University could drastically streamline drug interaction testing — replacing dozens of traditional experiments with just one. The research, led by Professor Jae Kyoung Kim of KAIST Department of Mathematical Sciences & IBS Biomedical Mathematics Group and Professor Sang Kyum Kim of Chungnam National University's College of Pharmacy, introduces a novel analysis technique called 50-BOA, published in Nature Communications on June 5, 2025. < Photo 1. (From left) Professor Sang Kyum Kim (Chungnam National University College of Pharmacy, co-corresponding author), Dr. Yun Min Song (IBS Biomedical Mathematics Group, formerly KAIST Department of Mathematical Sciences, co-first author), undergraduate student Hyeong Jun Jang (KAIST, co-first author), Professor Jae Kyoung Kim (KAIST and IBS Biomedical Mathematics Group, co-corresponding author) (Top left in the bubble) Professor Hwi-yeol Yun (Chungnam National University College of Pharmacy, co-author) > For decades, scientists have had to repeat drug inhibition experiments across a wide range of concentrations to estimate inhibition constants — a process seen in over 60,000 scientific publications. But the KAIST-led team discovered that a single, well-chosen inhibitor concentration can yield even more accurate results. < Figure 1. Graphical summary of 50-BOA. 50-BOA improves the accuracy and efficiency of inhibition constant estimation by using only a single inhibitor concentration instead of the traditionally used method of employing multiple inhibitor concentrations. > “This approach challenges long-standing assumptions in experimental pharmacology,” says Prof. Kim. “It shows how mathematics can fundamentally redesign life science experiments.” By mathematically analyzing the sources of error in conventional methods, the team found that over half the data typically collected adds no value or even skews results. Their new method not only cuts experimental effort by over 75%, but also enhances reproducibility and accuracy. To help researchers adopt the method quickly, the team developed a user-friendly tool that takes simple Excel files as input, now freely available on GitHub: ☞ https://github.com/Mathbiomed/50-BOA < Figure 2. The MATLAB and R package of 50-BOA at GitHub > The work holds promise for faster and more reliable drug development, especially in assessing potential interactions in combination therapies. The U.S. FDA already emphasizes the importance of accurate enzyme inhibition assessment during early-stage drug evaluation — and this method could soon become a new gold standard.
2025.06.16 View 5770
KAIST Turns an Unprecedented Idea into Reality: Quantum Computing with Magnets What started as an idea under KAIST’s Global Singularity Research Project—"Can we build a quantum computer using magnets?"—has now become a scientific reality. A KAIST-led international research team has successfully demonstrated a core quantum computing technology using magnetic materials (ferromagnets) for the first time in the world. KAIST (represented by President Kwang-Hyung Lee) announced on the 6th of May that a team led by Professor Kab-Jin Kim from the Department of Physics, in collaboration with the Argonne National Laboratory and the University of Illinois Urbana-Champaign (UIUC), has developed a “photon-magnon hybrid chip” and successfully implemented real-time, multi-pulse interference using magnetic materials—marking a global first. < Photo 1. Dr. Moojune Song (left) and Professor Kab-Jin Kim (right) of KAIST Department of Physics > In simple terms, the researchers developed a special chip that synchronizes light and internal magnetic vibrations (magnons), enabling the transmission of phase information between distant magnets. They succeeded in observing and controlling interference between multiple signals in real time. This marks the first experimental evidence that magnets can serve as key components in quantum computing, serving as a pivotal step toward magnet-based quantum platforms. The N and S poles of a magnet stem from the spin of electrons inside atoms. When many atoms align, their collective spin vibrations create a quantum particle known as a “magnon.” Magnons are especially promising because of their nonreciprocal nature—they can carry information in only one direction, which makes them suitable for quantum noise isolation in compact quantum chips. They can also couple with both light and microwaves, enabling the potential for long-distance quantum communication over tens of kilometers. Moreover, using special materials like antiferromagnets could allow quantum computers to operate at terahertz (THz) frequencies, far surpassing today’s hardware limitations, and possibly enabling room-temperature quantum computing without the need for bulky cryogenic equipment. To build such a system, however, one must be able to transmit, measure, and control the phase information of magnons—the starting point and propagation of their waveforms—in real time. This had not been achieved until now. < Figure 1. Superconducting Circuit-Based Magnon-Photon Hybrid System. (a) Schematic diagram of the device. A NbN superconducting resonator circuit fabricated on a silicon substrate is coupled with spherical YIG magnets (250 μm diameter), and magnons are generated and measured in real-time via a vertical antenna. (b) Photograph of the actual device. The distance between the two YIG spheres is 12 mm, a distance at which they cannot influence each other without the superconducting circuit. > Professor Kim’s team used two tiny magnetic spheres made of Yttrium Iron Garnet (YIG) placed 12 mm apart with a superconducting resonator in between—similar to those used in quantum processors by Google and IBM. They input pulses into one magnet and successfully observed lossless transmission of magnon vibrations to the second magnet via the superconducting circuit. They confirmed that from single nanosecond pulses to four microwave pulses, the magnon vibrations maintained their phase information and demonstrated predictable constructive or destructive interference in real time—known as coherent interference. By adjusting the pulse frequencies and their intervals, the researchers could also freely control the interference patterns of magnons, effectively showing for the first time that electrical signals can be used to manipulate magnonic quantum states. This work demonstrated that quantum gate operations using multiple pulses—a fundamental technique in quantum information processing—can be implemented using a hybrid system of magnetic materials and superconducting circuits. This opens the door for the practical use of magnet-based quantum devices. < Figure 2. Experimental Data. (a) Measurement results of magnon-magnon band anticrossing via continuous wave measurement, showing the formation of a strong coupling hybrid system. (b) Magnon pulse exchange oscillation phenomenon between YIG spheres upon single pulse application. It can be seen that magnon information is coherently transmitted at regular time intervals through the superconducting circuit. (c,d) Magnon interference phenomenon upon dual pulse application. The magnon information state can be arbitrarily controlled by adjusting the time interval and carrier frequency between pulses. > Professor Kab-Jin Kim stated, “This project began with a bold, even unconventional idea proposed to the Global Singularity Research Program: ‘What if we could build a quantum computer with magnets?’ The journey has been fascinating, and this study not only opens a new field of quantum spintronics, but also marks a turning point in developing high-efficiency quantum information processing devices.” The research was co-led by postdoctoral researcher Moojune Song (KAIST), Dr. Yi Li and Dr. Valentine Novosad from Argonne National Lab, and Prof. Axel Hoffmann’s team at UIUC. The results were published in Nature Communications on April 17 and npj Spintronics on April 1, 2025. Paper 1: Single-shot magnon interference in a magnon-superconducting-resonator hybrid circuit, Nat. Commun. 16, 3649 (2025) DOI: https://doi.org/10.1038/s41467-025-58482-2 Paper 2: Single-shot electrical detection of short-wavelength magnon pulse transmission in a magnonic ultra-thin-film waveguide, npj Spintronics 3, 12 (2025) DOI: https://doi.org/10.1038/s44306-025-00072-5 The research was supported by KAIST’s Global Singularity Research Initiative, the National Research Foundation of Korea (including the Mid-Career Researcher, Leading Research Center, and Quantum Information Science Human Resource Development programs), and the U.S. Department of Energy.
2025.06.12 View 8074
KAIST Develops Virtual Staining Technology for 3D Histopathology Moving beyond traditional methods of observing thinly sliced and stained cancer tissues, a collaborative international research team led by KAIST has successfully developed a groundbreaking technology. This innovation uses advanced optical techniques combined with an artificial intelligence-based deep learning algorithm to create realistic, virtually stained 3D images of cancer tissue without the need for serial sectioning nor staining. This breakthrough is anticipated to pave the way for next-generation non-invasive pathological diagnosis. < Photo 1. (From left) Juyeon Park (Ph.D. Candidate, Department of Physics), Professor YongKeun Park (Department of Physics) (Top left) Professor Su-Jin Shin (Gangnam Severance Hospital), Professor Tae Hyun Hwang (Vanderbilt University School of Medicine) > KAIST (President Kwang Hyung Lee) announced on the 26th that a research team led by Professor YongKeun Park of the Department of Physics, in collaboration with Professor Su-Jin Shin's team at Yonsei University Gangnam Severance Hospital, Professor Tae Hyun Hwang's team at Mayo Clinic, and Tomocube's AI research team, has developed an innovative technology capable of vividly displaying the 3D structure of cancer tissues without separate staining. For over 200 years, conventional pathology has relied on observing cancer tissues under a microscope, a method that only shows specific cross-sections of the 3D cancer tissue. This has limited the ability to understand the three-dimensional connections and spatial arrangements between cells. To overcome this, the research team utilized holotomography (HT), an advanced optical technology, to measure the 3D refractive index information of tissues. They then integrated an AI-based deep learning algorithm to successfully generate virtual H&E* images.* H&E (Hematoxylin & Eosin): The most widely used staining method for observing pathological tissues. Hematoxylin stains cell nuclei blue, and eosin stains cytoplasm pink. The research team quantitatively demonstrated that the images generated by this technology are highly similar to actual stained tissue images. Furthermore, the technology exhibited consistent performance across various organs and tissues, proving its versatility and reliability as a next-generation pathological analysis tool. < Figure 1. Comparison of conventional 3D tissue pathology procedure and the 3D virtual H&E staining technology proposed in this study. The traditional method requires preparing and staining dozens of tissue slides, while the proposed technology can reduce the number of slides by up to 10 times and quickly generate H&E images without the staining process. > Moreover, by validating the feasibility of this technology through joint research with hospitals and research institutions in Korea and the United States, utilizing Tomocube's holotomography equipment, the team demonstrated its potential for full-scale adoption in real-world pathological research settings. Professor YongKeun Park stated, "This research marks a major advancement by transitioning pathological analysis from conventional 2D methods to comprehensive 3D imaging. It will greatly enhance biomedical research and clinical diagnostics, particularly in understanding cancer tumor boundaries and the intricate spatial arrangements of cells within tumor microenvironments." < Figure 2. Results of AI-based 3D virtual H&E staining and quantitative analysis of pathological tissue. The virtually stained images enabled 3D reconstruction of key pathological features such as cell nuclei and glandular lumens. Based on this, various quantitative indicators, including cell nuclear distribution, volume, and surface area, could be extracted. > This research, with Juyeon Park, a student of the Integrated Master’s and Ph.D. Program at KAIST, as the first author, was published online in the prestigious journal Nature Communications on May 22. (Paper title: Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining. [https://doi.org/10.1038/s41467-025-59820-0] This study was supported by the Leader Researcher Program of the National Research Foundation of Korea, the Global Industry Technology Cooperation Center Project of the Korea Institute for Advancement of Technology, and the Korea Health Industry Development Institute.
2025.05.26 View 7700
KAIST and Mainz Researchers Unveil 3D Magnon Control, Charting a New Course for Neuromorphic and Quantum Technologies < Professor Se Kwon Kim of the Department of Physics (left), Dr. Zarzuela of the University of Mainz, Germany (right) > What if the magnon Hall effect, which processes information using magnons (spin waves) capable of current-free information transfer with magnets, could overcome its current limitation of being possible only on a 2D plane? If magnons could be utilized in 3D space, they would enable flexible design, including 3D circuits, and be applicable in various fields such as next-generation neuromorphic (brain-mimicking) computing structures, similar to human brain information processing. KAIST and an international joint research team have, for the first time in the world, predicted a 3D magnon Hall effect, demonstrating that magnons can move freely and complexly in 3D space, transcending the conventional concept of magnons. KAIST (President Kwang Hyung Lee) announced on May 22nd that Professor Se Kwon Kim of the Department of Physics, in collaboration with Dr. Ricardo Zarzuela of the University of Mainz, Germany, has revealed that the interaction between magnons (spin waves) and solitons (spin vortices) within complex magnetic structures (topologically textured frustrated magnets) is not simple, but complex in a way that enables novel functionalities. Magnons (spin waves), which can transmit information like electron movement, are garnering attention as a next-generation information processing technology that transmits information without using current, thus generating no heat. Until now, magnon research has focused on simple magnets where spins are neatly aligned in one direction, and the mathematics describing this was a relatively simple 'Abelian gauge theory.' The research team demonstrated, for the first time in the world, that in complex spin structures like frustrated magnets, magnons interact and become entangled in complex ways from various directions. They applied an advanced mathematical framework, 'non-Abelian gauge theory,' to describe this movement, which is a groundbreaking achievement. This research presents the possibility of future applications in low-power logic devices using magnons and topology-based quantum information processing technologies, indicating a potential paradigm shift in future information technology. In conventional linear magnetic materials, the value representing the magnetic state (order parameter) is given as a vector. In magnonics research based on this, it has been interpreted that a U(1) Abelian gauge field is induced when magnons move in soliton structures like skyrmions. This means that the interaction between solitons and magnons has a structure similar to quantum electrodynamics (QED), which has successfully explained various experimental results such as the magnon Hall effect in 2D magnets. < Figure. Schematic diagram of non-Abelian magnon quantum chromodynamics describing the dynamics of three types of magnons discovered for the first time in this study.> However, through this research, the team theoretically revealed that in frustrated magnets, the order parameter must be expressed not as a simple vector but as a quaternion. As a result, the gauge field experienced by magnons resembles an SU(3) non-Abelian gauge field, rather than a simple U(1) Abelian gauge field. This implies that within frustrated magnets, there are not one or two types of magnons seen in conventional magnets, but three distinct types of magnons, each interacting and intricately entangled with solitons. This structure is highly significant as it resembles quantum chromodynamics (QCD) that describes the strong interaction between quarks mediated by gluons rather than quantum electrodynamics (QED) that describes electromagnetic forces. Professor Se Kwon Kim stated, "This research presents a powerful theoretical framework to explain the dynamics of magnons occurring within the complex order of frustrated magnets," adding, "By pioneering non-Abelian magnonics, it will be a conceptual turning point that can influence quantum magnetism research as a whole." The research results, with Dr. Ricardo Zarzuela of the University of Mainz, Germany, as the first author, were published in the world-renowned physics journal Physical Review Letters on May 6th.※ Paper title: "Non-Abelian Gauge Theory for Magnons in Topologically Textured Frustrated Magnets," Phys. Rev. Lett. 134, 186701 (2025)DOI: https://doi.org/10.1103/PhysRevLett.134.186701 This research was supported by the Brain Pool Plus program of the National Research Foundation of Korea.
2025.05.22 View 6579
Life Springs at KAIST: A Tale of Two Special Campus Families A Gift of Life on Teachers' Day: Baby Geese Born at KAIST Pond On Teachers' Day, a meaningful miracle of life arrived at the KAIST campus. A pair of geese gave birth to two goslings by the duck pond. < On Teachers' Day, a pair of geese and their goslings leisurely swim in the pond. > The baby goslings, covered in yellow down, began exploring the pond's edge, scurrying about, while their aunt geese steadfastly stood by. Their curious glances, watchful gazes, playful hops on waterside rocks, and the procession of babies swimming behind their parents in the water melted the hearts of onlookers. < As night falls on the duck pond, the goose family gathers among the reeds. > This special new life, born on Teachers' Day, seems to symbolize the day's meaning of "care" and "growth." This wondrous scene of life brought warm comfort and joy to KAIST members, adding the inspiration of nature to a campus that is a space for research and learning. < Under the protection of the adult geese, the goslings take their first steps, exploring the pond's grassy areas and rocks. > This adorable family is already roaming the area leisurely, like the pond's owners. With the joy of life added to the spring-filled pond, warm smiles are spreading across the KAIST campus. < The geese look around, surveying their surroundings, while caring for their goslings. > The pond has now become a small but special haven for students and staff. This goose family, arriving on Teachers' Day, quietly reminds us of the meaning of care and learning conveyed by nature. < The goose family shows care and growth, and warm moments together are anticipated. > --- On Children's Day 2025, a Duck Becomes a Mother In July 2024, a special guest arrived at the KAIST campus. With soft yellow down, waddling gait, and a flat beak, it was undeniably a baby duck. However, for some reason, its mother was nowhere to be seen. Given that it wasn't afraid of people and followed them well, it was clear that someone had abandoned the duck. Fortunately, the baby duck was safely rescued thanks to prompt reporting by students. < Two ducks found on a corner of campus, immediately after their rescue in summer 2024. > The ducks, newly integrated into KAIST, seemed to adapt relatively peacefully to campus life. As new additions, they couldn't blend in with the existing goose flock that had settled on campus, but the geese didn't ostracize them either. Perhaps because they were awkward neighbors, there was hope that the ducks would soon join the existing goose flock. < Following their rescue based on a student's report in summer 2024, the ducks adapted to campus life under the protection of the campus facility team and Professor Won Do Heo. > Professor Won Do Heo of the Department of Biological Sciences, widely known as "Goose Dad," stepped forward to protect them along with the KAIST facility team. Professor Heo is well-known for consistently observing and protecting the campus geese and ducks, which are practically symbols of KAIST. Thanks to the care of the staff and Professor Heo, the two ducks were safely released back onto campus approximately one month after their rescue. < A moment on campus: Before winter, the ducks lived separately from the goose flock, maintaining a certain distance. While there were no conflicts, they rarely socialized. > However, as winter passed, sad news arrived. One duck went missing, and the remaining one was found injured by the pond. While the policy of the facility team and Professor Heo was to minimize intervention to allow campus animals to maintain their natural state, saving the injured duck was the top priority. After being isolated again for a month of recovery, the duck fully recovered and was able to greet spring under the sun. < The mother duck left alone in winter: One went missing, and the remaining one was found injured. After indoor isolation and recovery, she was released back onto campus in the spring. > As spring, the ducks' breeding season, began, Professor Heo decided to offer a little more help. When signs of egg-laying appeared, he consistently provided "special meals for pregnant mothers" throughout March. On the morning of May 5th, Children's Day, 28 days after the mother duck began incubating her eggs with the care and attention of KAIST members, new life finally hatched. It was a precious outcome achieved solely by the duck that had survived abandonment and injury, with no special protection other than food. The duck, having overcome hardship and injury to stand alone, has now formed a new family. Although there is still some distance from the existing goose flock, it is expected that they will naturally find their place in the campus ecosystem, as KAIST's geese are not aggressive or exclusive. The KAIST goose flock already has experience protecting and raising five ducklings. < A new beginning by the pond on Children's Day: On the morning of May 5th, the 28th day of incubation, four ducklings hatched by the pond. This was a natural hatching, achieved without protective equipment. > A single duck brought a special spring to the KAIST campus on Children's Day. The outcome achieved by that small life, leading to the birth of a new family, also symbolizes the harmonious coexistence of people and animals on the KAIST campus. The careful intervention of KAIST members, providing only the necessary assistance from rescue to hatching, makes us reconsider what "desirable coexistence between animals and people" truly means.
2025.05.21 View 6240
KAIST Captures Protein Reaction in Just Six Milliseconds Understanding biomolecular processes - such as protein-protein interactions and enzyme-substrate reactions that occur on the microseconds to millisecond time scale is essential for comprehending life processes and advancing drug development. KAIST researchers have developed a method for freezing and analyzing biochemical reaction dynamics within a span of just a few milliseconds, marking a significant step forward in better understanding complex biological reactions. < Photo. (From left) Professor Jin Young Kang and Haerang Hwang of the Integrated Master's and Doctoral Program of the Department of Chemistry, along with Professor Wonhee Lee of the Department of Physics > KAIST (represented by President Kwang Hyung Lee) announced on the 24th of March that a joint research team led by Professor Jin Young Kang from the Department of Chemistry and Professor Wonhee Lee from the Department of Physics has developed a parylene-based thin-film microfluidic mixing-and-spraying device for ultra-fast biochemical reaction studies. *Parylene: A key material for microfluidic devices used to observe protein dynamics at ultra-high speeds. It can be fabricated into a few micrometer-thick films, which can be used in making a spray nozzle for microfluidic devices. This research overcomes the limitations of the existing time-resolved cryo-electron microscopy (TRCEM) method by reducing sample consumption to one-third of the conventional amount while improving the minimum time resolution—down to just six milliseconds (6 ms). TRCEM is a technique that rapidly freezes protein complexes during intermediate reaction stages under cryogenic conditions, which allows researchers to analyze their structures. This approach has gained significant attention recently for its ability to capture transient biochemical events. < Figure 1. Time-resolved cryo-EM (TRCEM) technique using microfluidic channels. In order to capture the intermediate structure of biomolecules during a biochemical reaction over time, biomolecules and reaction substrates are mixed in a microfluidic channel, and then sprayed on a grid after a certain reaction time and frozen in liquid ethane to prepare a cryo-EM sample. This can then be analyzed by cryo-EM to observe the structural changes of proteins over time. > Transient intermediate structures of protein complexes could not be captured by traditional cryo-electron microscopy due to their extremely short lifespans. Although several TRCEM techniques have been developed to address this issue, previous methods were hindered by large sample consumption and limited time resolution. To overcome these challenges, the KAIST team developed a new mixing-and-spraying device using ultra-thin parylene films. The integrated design of the device further enhanced the precision and reproducibility of experiments. < Figure 2. TRCEM grid fabrication setup using a parylene-based thin-film microfluidic device and actual appearance of the device. You can see that a thin-film parylene channel is inserted into the injection nozzle. The integration of the reaction channel and the injection nozzle allowed the residence time in the device to be reduced to at least 0.5 ms. > “This research makes TRCEM more practical and paves the way for diverse applications of the parylene thin-film device in structural biology, drug development, enzyme reaction studies, and biosensor research.” Professor Jin Young Kang explained, emphasizing the significance of the study. Professor Wonhee Lee added, “The team aims to continue this research, focusing on improvement of the technique to achieve higher time resolution with minimal sample consumption.” < Figure 3. Comparison of the spraying patterns of the parylene mixing-jet device and the conventional mixing-jet device and the filament length in the resulting RecA-ssDNA filament formation reaction. It was shown that the thin film spray nozzle structure affects the uniformity and accuracy of the final reaction time. > The research findings, with Haerang Hwang (a graduate student in the integrated master's and Ph.D. program in the Department of Chemistry) as the first author, were published online on January 28, 2025, in the international journal Advanced Functional Materials. (Paper Title: “Integrated Parylene-Based Thin-Film Microfluidic Device for Time-Resolved Cryo-Electron Microscopy”, DOI: doi.org/10.1002/adfm.202418224) This research was supported by the National Research Foundation of Korea (NRF), the Samsung Future Technology Development Program, and the CELINE consortium.
2025.03.24 View 7378
KAIST Captures Hot Holes: A Breakthrough in Light-to-Electricity Energy Conversion When light interacts with metallic nanostructures, it instantaneously generates plasmonic hot carriers, which serve as key intermediates for converting optical energy into high-value energy sources such as electricity and chemical energy. Among these, hot holes play a crucial role in enhancing photoelectrochemical reactions. However, they thermally dissipate within picoseconds (trillionths of a second), making practical applications challenging. Now, a Korean research team has successfully developed a method for sustaining hot holes longer and amplifying their flow, accelerating the commercialization of next-generation, high-efficiency, light-to-energy conversion technologies. KAIST (represented by President Kwang Hyung Lee) announced on the 12th of March that a research team led by Distinguished Professor Jeong Young Park from the Department of Chemistry, in collaboration with Professor Moonsang Lee from the Department of Materials Science and Engineering at Inha University, has successfully amplified the flow of hot holes and mapped local current distribution in real time, thereby elucidating the mechanism of photocurrent enhancement. The team designed a nanodiode structure by placing a metallic nanomesh on a specialized semiconductor substrate (p-type gallium nitride) to facilitate hot hole extraction at the surface. As a result, in gallium nitride substrates aligned with the hot hole extraction direction, the flow of hot holes was amplified by approximately two times compared to substrates aligned in other directions. To fabricate the Au nanomesh, a polystyrene nano-bead monolayer assembly was first placed on a gallium nitride (p-GaN) substrate, and then the polystyrene nano-beads were etched to form a nanomesh template (Figure 1A). Then, a 20 nm thick gold nano-film was deposited, and the etched polystyrene nano-beads were removed to realize the gold nano-mesh structure on the GaN substrate (Figure 1B). The fabricated Au nanomesh exhibited strong light absorption in the visible range due to the plasmonic resonance effect (Figure 1C). > Furthermore, using a photoconductive atomic force microscopy (pc-AFM)-based photocurrent mapping system, the researchers analyzed the flow of hot holes in real time at the nanometer scale (one hundred-thousandth the thickness of a human hair). They observed that hot hole activation was strongest at "hot spots," where light was locally concentrated on the gold nanomesh. However, by modifying the growth direction of the gallium nitride substrate, hot hole activation extended beyond the hot spots to other areas as well. Through this research, the team discovered an efficient method for converting light into electrical and chemical energy. This breakthrough is expected to significantly advance next-generation solar cells, photocatalysts, and hydrogen production technologies. Professor Jeong Young Park stated, "For the first time, we have successfully controlled the flow of hot holes using a nanodiode technique. This innovation holds great potential for various optoelectronic devices and photocatalytic applications. For example, it could lead to groundbreaking advancements in solar energy conversion technologies, such as solar cells and hydrogen production. Additionally, the real-time analysis technology we developed can be applied to the development of ultra-miniaturized optoelectronic devices, including optical sensors and nanoscale semiconductor components." The study was led by Hyunhwa Lee (PhD., KAIST Department of Chemistry) and Yujin Park (Postdoc Researcher, University of Texas at Austin Department of Chemical Engineering) as co-first authors and Professors Moonsang Lee (Inha University, Department of Materials Science and Engineering) and Jeong Young Park (KAIST, Department of Chemistry) serving as corresponding authors. The research findings were published online in Science Advances on March 7. (Paper Title: “Reconfiguring hot-hole flux via polarity modulation of p-GaN in plasmonic Schottky architectures”, DOI: https://www.science.org/doi/10.1126/sciadv.adu0086) This research was supported by the National Research Foundation of Korea (NRF).
2025.03.17 View 7335
KAIST achieves quantum entanglement essential for quantum error correction Quantum computing is a technology capable of solving complex problems that classical computers struggle with. To perform accurate computations, quantum computers must correct errors that arise during operations. However, generating the quantum entanglement necessary for quantum error correction has long been considered a major challenge. < Photo 1. (From left) Students Young-Do Yoon and Chan Roh of the Master's and Doctoral Integrated Program of the Department of Physics poses with Professor Young-Sik Ra and Student Geunhee Gwak of the same program > KAIST (represented by President Kwang Hyung Lee) announced on the 25th of February that a research team led by Professor Young-Sik Ra from the Department of Physics has successfully implemented a three-dimensional cluster quantum entangled state, a key component for quantum error correction, through experimental demonstration. Measurement-based quantum computing is an emerging paradigm that implements quantum computations by measuring specially entangled cluster states. The core of this approach lies in the generation of these cluster quantum entangled states, with two-dimensional cluster states commonly used for universal quantum computing. However, to advance towards fault-tolerant quantum computing, which can correct quantum errors occurring during computations, a more complex three-dimensional cluster state is required. While previous studies have reported the generation of two-dimensional cluster states, experimental implementation of the three-dimensional cluster states necessary for fault-tolerant quantum computing had remained elusive due to the extreme complexity of their entanglement structure. < Figure 1. (a) Experimental schematic. A pulse laser with a wavelength of 800 nm is converted into a pulse laser with a wavelength of 400 nm through second harmonic generation, and this is incident on a nonlinear crystal (PPKTP) to generate multiple quantum entanglement sources. (b) Generation of a 3D cluster state through optical mode basis change > The research team overcame this challenge by developing a technique to control femtosecond time-frequency modes, successfully generating a three-dimensional cluster quantum entangled state for the first time. The team directed a femtosecond laser into a nonlinear crystal, simultaneously generating quantum light sources across multiple frequency modes. (A femtosecond laser is a device that emits ultrashort, high-intensity light pulses.) Using this approach, they successfully created a three-dimensional cluster quantum entangled state. Professor Young-Sik Ra noted, “This study marks the first successful demonstration of a three-dimensional cluster quantum entangled state, which was previously difficult to achieve with existing technology. This breakthrough is expected to serve as a crucial stepping stone for future research in measurement-based and fault-tolerant quantum computing.” < Figure 2. Results of 3D cluster state generation. (a) Nullifier measurement of the cluster state. (b) 3D cluster state reconstructed using quantum state tomography. (c) Confirmation of quantum entanglement characteristics of the 3D cluster state > The study was published online in Nature Photonics on February 24, 2025. The first author is Chan Roh, a Ph.D. candidate in KAIST’s integrated master’s and doctoral program, with Geunhee Gwak and Youngdo Yoon contributing as co-authors. (Paper title: “Generation of Three-Dimensional Cluster Entangled State”, DOI: 10.1038/s41566-025-01631-2) This research was supported by the National Research Foundation of Korea (Quantum Computing Technology Development Program, Mid-Career Researcher Support Program, and Quantum Simulator for Materials Innovation Program), the Institute for Information & Communications Technology Planning & Evaluation (Quantum Internet Core Technology Program, University ICT Research Center Support Program), and the U.S. Air Force Research Laboratory.
2025.02.25 View 6872
KAIST Proves Possibility of Preventing Hair Loss with Polyphenol Coating Technology - KAIST's Professor Haeshin Lee's research team of the Department of Chemistry developed tannic scid-based hair coating technology - Hair protein (hair and hair follicle) targeting delivery technology using polyphenol confirms a hair loss reduction effect of up to 90% to manifest within 7 Days - This technology, first applied to 'Grabity' shampoo, proves effect of reducing hair loss chemically and physically < Photo. (From left) KAIST Chemistry Department Ph.D. candidate Eunu Kim, Professor Haeshin Lee > Hair loss is a problem that hundreds of millions of people around the world are experiencing, and has a significant psychological and social impact. KAIST researchers focused on the possibility that tannic acid, a type of natural polyphenol, could contribute to preventing hair loss, and through research, discovered that tannic acid is not a simple coating agent, but rather acts as an 'adhesion mediator' that alleviates hair loss. KAIST (President Kwang-Hyung Lee) announced on the 6th that the Chemistry Department Professor Haeshin Lee's research team developed a new hair loss prevention technology that slowly releases hair loss-alleviating functional ingredients using tannic acid-based coating technology. Hair loss includes androgenetic alopecia (AGA) and telogen effluvium (TE), and genetic, hormonal, and environmental factors work together, and there is currently a lack of effective treatments with few side effects. Representative hair loss treatments, minoxidil and finasteride, show some effects, but require long-term use, and not only do their effects vary depending on the body type, but some users also experience side effects. Professor Haeshin Lee's research team proved that tannic acid can strongly bind to keratin, the main protein in hair, and can be continuously attached to the hair surface, and confirmed that this can be used to release specific functional ingredients in a controlled manner. In particular, the research team developed a combination that included functional ingredients for hair loss relief, such as salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL), and named it 'SCANDAL.' The research results showed that the Scandal complex combined with tannic acid is gradually released when it comes into contact with water and is delivered to the hair follicles along the hair surface. < Figure 1. Schematic diagram of the hair loss relief mechanism by the tannic acid/SCANDAL complex. Tannic acid is a polyphenol compound containing a galol group that has a 360-degree adhesive function, and it binds to the hair surface on one side and binds to the hair loss relief functional ingredient SCANDAL on the other side to store it on the hair surface. Afterwards, when it comes into contact with moisture, SCANDAL is gradually released and delivered to the scalp and hair follicles to show the hair loss relief effect. > The research team of Goodmona Clinic (Director: Geon Min Lee) applied the shampoo containing tannic acid/Scandal complex to 12 hair loss patients for 7 days, and observed a significant hair loss reduction effect in all clinicians. The results of the experiment showed a reduction in average hair loss of 56.2%, and there were cases where hair loss was reduced by up to 90.2%. This suggests that tannic acid can be effective in alleviating hair loss by stably maintaining the Scandal component on the hair surface and gradually releasing it and delivering it to the hair follicles. < Figure 2. When a tannic acid coating is applied to untreated bleached hair, a coating is formed as if the cuticles are tightly attached to each other. This was confirmed through X-ray photoelectron spectroscopy (XPS) analysis, and a decrease in signal intensity was observed in the surface analysis of nitrogen of amino acids contained in keratin protein after tannic acid coating. This proves that tannic acid successfully binds to the hair surface and covers the existing amino acids. To verify this more clearly, the oxidation-reduction reaction was induced through gold ion treatment, and as a result, the entire hair turned black, and it was confirmed that tannic acid reacted with gold ions on the hair surface to form a tannic acid-gold complex. > Professor Haeshin Lee said, “We have successfully proven that tannic acid, a type of natural polyphenol, has a strong antioxidant effect and has the property of strongly binding to proteins, so it can act as a bio-adhesive.” Professor Lee continued, “Although there have been cases of using it as a skin and protein coating material in previous studies, this study is the first case of combining with hair and delivering hair loss relief ingredients, and it was applied to ‘Grabity’ shampoo commercialized through Polyphenol Factory, a startup company. We are working to commercialize more diverse research results, such as shampoos that dramatically increase the strength of thin hair that breaks and products that straighten curly hair.” < Figure 3. Tannic acid and the hair loss relief functional ingredient (SCANDAL) formed a stable complex through hydrogen bonding, and it was confirmed that tannic acid bound to the hair could effectively store SCANDAL. In addition, the results of transmission electron microscopy analysis of salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL) showed that all of them formed tannic acid-SCANDAL nanocomplexes. > The results of this study, in which a Ph.D. candidate KAIST Department of Chemistry, Eunu Kim, was the first author and Professor Haeshin Lee was the corresponding author, were published in the online edition of the international academic journal ‘Advanced Materials Interfaces’ on January 6. (Paper title: Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation) DOI: 10.1002/admi.202400851 < Figure 4. The hair loss relief functional ingredient (SCANDAL) stored on the hair surface with tannic acid was slowly released upon contact with moisture and delivered to the hair follicle along the hair surface. Salicylic acid (SCA) and niacinamide (N) were each released by more than 25% within 10 minutes. When shampoo containing tannic acid/SCANDAL complex was applied to the hair of 12 participants, hair loss was reduced by about 56.2% on average, and the reduction rate ranged from a minimum of 26.6% to a maximum of 90.2%. These results suggest that tannic acid stably binds SCANDAL to the hair surface, which allows for its gradual release into the hair follicle, resulting in a hair loss alleviation effect. > This study was conducted with the support of Polyphenol Factory, a KAIST faculty startup company.
2025.02.06 View 9485